The Development and Improvement of Instructions
MECHANICS OF ATHEROSCLEROSIS, HYPERTENSION INDUCED GROWTH, AND ARTERIAL REMODELING A Dissertation by HEATHER NAOMI HAYENGA Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY May 2011 Major Subject: Biomedical Engineering Mechanics of Atherosclerosis, Hypertension Induced Growth, and Arterial Remodeling Copyright 2011 Heather Naomi Hayenga MECHANICS OF ATHEROSCLEROSIS, HYPERTENSION INDUCED GROWTH, AND ARTERIAL REMODELING A Dissertation by HEATHER NAOMI HAYENGA Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY Approved by: Chair of Committee, James E. Moore, Jr. Committee Members, Fred J. Clubb Roland R. Kaunas Alvin T. Yeh Head of Department, Gerald L. Cote May 2011 Major Subject: Biomedical Engineering iii ABSTRACT Mechanics of Atherosclerosis, Hypertension Induced Growth, and Arterial Remodeling. (December 2010) Heather Naomi Hayenga, B.S., University of California, Davis Chair of Advisory Committee: Dr. James E. Moore, Jr. In order to create informed predictive models that capture artery dependent responses during atherosclerosis progression and the long term response to hypertension, one needs to know the structural, biochemical and mechanical properties as a function of time in these diseased states. In the case of hypertension more is known about the mechanical changes; while, less is known about the structural changes over time. For atherosclerotic plaques, more is known about the structure and less about the mechanical properties. We established a congruent multi-scale model to predict the adapted salient arterial geometry, structure and biochemical response to an increase in pressure.
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