Creatine Kinase, Mitochondrial 1A (CKMT1A) Antibody Catalogue No.:Abx004020

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Datasheet Version: 1.0.0 Revision date: 23 Nov 2020 Creatine Kinase, Mitochondrial 1A (CKMT1A) Antibody Catalogue No.:abx004020 Western blot analysis of extracts of various cell lines, using CKMT1A Antibody (abx004020) at 1/1000 dilution. CKMT1A Antibody is a Rabbit Polyclonal antibody against CKMT1A. Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. Target: CKMT1A Clonality: Polyclonal Reactivity: Human, Mouse, Rat Tested Applications: WB Host: Rabbit Recommended dilutions:ForWB: 1/500 Reference- 1/2000. Optimal dilutions/concentrations should be determinedOnly by the end user. Conjugation: Unconjugated Immunogen: Recombinant protein of human CKMT1A. Isotype: IgG Form: Liquid Purification: Affinity purified. v1.0.0 Abbexa Ltd, Cambridge, UK · Phone: +44 1223 755950 · Fax: +44 1223 755951 1 Abbexa LLC, Houston, TX, USA · Phone: +1 832 327 7413 www.abbexa.com · Email: [email protected] Datasheet Version: 1.0.0 Revision date: 23 Nov 2020 Storage: Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. UniProt Primary AC: P12532 (UniProt, ExPASy) Gene Symbol: CKMT1A GeneID: 548596 Molecular Weight: Calculated MW: 47 kDa, 50 kDa Observed MW: 47 kDa Buffer: PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. Concentration: > 1 mg/ml Note: This product is for research use only. For Reference Only v1.0.0 Abbexa Ltd, Cambridge, UK · Phone: +44 1223 755950 · Fax: +44 1223 755951 2 Abbexa LLC, Houston, TX, USA · Phone: +1 832 327 7413 www.abbexa.com · Email: [email protected].

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Creatine Kinase (CK)
P.O. Box 131375, Bryanston, 2074 Ground Floor, Block 5 Bryanston Gate, Main Road Bryanston, Johannesburg, South Africa www.thistle.co.za Tel: +27 (011) 463-3260 Fax: +27 (011) 463-3036 e-mail : [email protected] Please read this bit first The HPCSA and the Med Tech Society have confirmed that this clinical case study, plus your routine review of your EQA reports from Thistle QA, should be documented as a “Journal Club” activity. This means that you must record those attending for CEU purposes. Thistle will not issue a certificate to cover these activities, nor send out “correct” answers to the CEU questions at the end of this case study. The Thistle QA CEU No is: MT00025. Each attendee should claim THREE CEU points for completing this Quality Control Journal Club exercise, and retain a copy of the relevant Thistle QA Participation Certificate as proof of registration on a Thistle QA EQA. CHEMISTRY LEGEND August 2009 Creatine kinase (CK) Creatine kinase (CK), also known as Creatine phosphokinase (CPK) or phospho-creatine kinase or sometimes wrongfully also creatinine kinase, is an enzyme expressed by various tissues and cell types. CK catalyses the conversion of Creatine and consumes adenosine triphosphate (ATP) to create phospho-creatine (PCr) and adenosine diphosphate (ADP). This CK enzyme reaction is reversible, such that also ATP can be generated from PCr and ADP. In tissues and cells that consume ATP rapidly, especially skeletal muscle, but also brain, photoreceptor cells of the retina, hair cells of the inner ear, spermatozoa and smooth muscle, phospho-creatine serves as an energy reservoir for the rapid buffering and regeneration of ATP in situ, as well as for intracellular energy transport by the phospho-creatine shuttle or circuit.
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P.O. Box 131375, Bryanston, 2074 Ground Floor, Block 5 Bryanston Gate, 170 Curzon Road Bryanston, Johannesburg, South Africa 804 Flatrock, Buiten Street, Cape Town, 8001 www.thistle.co.za Tel: +27 (011) 463 3260 Fax: +27 (011) 463 3036 Fax to Email: + 27 (0) 86-557-2232 e-mail : [email protected] Please read this section first The HPCSA and the Med Tech Society have confirmed that this clinical case study, plus your routine review of your EQA reports from Thistle QA, should be documented as a “Journal Club” activity. This means that you must record those attending for CEU purposes. Thistle will not issue a certificate to cover these activities, nor send out “correct” answers to the CEU questions at the end of this case study. The Thistle QA CEU No is: MT-2014/004. Each attendee should claim THREE CEU points for completing this Quality Control Journal Club exercise, and retain a copy of the relevant Thistle QA Participation Certificate as proof of registration on a Thistle QA EQA. CHEMISTRY LEGEND JULY 2014 Creatine kinase (CK) Creatine kinase (CK), also known as Creatine phosphokinase (CPK) or phospho-creatine kinase or sometimes wrongfully also creatinine kinase, is an enzyme expressed by various tissues and cell types. CK catalyses the conversion of Creatine and consumes adenosine triphosphate (ATP) to create phospho-creatine (PCr) and adenosine diphosphate (ADP). This CK enzyme reaction is reversible, such that also ATP can be generated from PCr and ADP. In tissues and cells that consume ATP rapidly, especially skeletal muscle, but also brain, photoreceptor cells of the retina, hair cells of the inner ear, spermatozoa and smooth muscle, phospho-creatine serves as an energy reservoir for the rapid buffering and regeneration of ATP in situ, as well as for intracellular energy transport by the phospho-creatine shuttle or circuit.
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