Improving Ecological Inference by Predicting Individual Ethnicity from Voter Registration Records
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Design and Implementation of N-Of-1 Trials: a User's Guide
Design and Implementation of N-of-1 Trials: A User’s Guide N of 1 The Agency for Healthcare Research and Quality’s (AHRQ) Effective Health Care Program conducts and supports research focused on the outcomes, effectiveness, comparative clinical effectiveness, and appropriateness of pharmaceuticals, devices, and health care services. More information on the Effective Health Care Program and electronic copies of this report can be found at www.effectivehealthcare.ahrq. gov. This report was produced under contract to AHRQ by the Brigham and Women’s Hospital DEcIDE (Developing Evidence to Inform Decisions about Effectiveness) Methods Center under Contract No. 290-2005-0016-I. The AHRQ Task Order Officer for this project was Parivash Nourjah, Ph.D. The findings and conclusions in this document are those of the authors, who are responsible for its contents; the findings and conclusions do not necessarily represent the views ofAHRQ or the U.S. Department of Health and Human Services. Therefore, no statement in this report should be construed as an official position of AHRQ or the U.S. Department of Health and Human Services. Persons using assistive technology may not be able to fully access information in this report. For assistance contact [email protected]. The following investigators acknowledge financial support: Dr. Naihua Duan was supported in part by NIH grants 1 R01 NR013938 and 7 P30 MH090322, Dr. Heather Kaplan is part of the investigator team that designed and developed the MyIBD platform, and this work was supported in part by Cincinnati Children’s Hospital Medical Center. Dr. Richard Kravitz was supported in part by National Institute of Nursing Research Grant R01 NR01393801. -
Generalized Linear Models for Aggregated Data
Generalized Linear Models for Aggregated Data Avradeep Bhowmik Joydeep Ghosh Oluwasanmi Koyejo University of Texas at Austin University of Texas at Austin Stanford University [email protected] [email protected] [email protected] Abstract 1 Introduction Modern life is highly data driven. Datasets with Databases in domains such as healthcare are records at the individual level are generated every routinely released to the public in aggregated day in large volumes. This creates an opportunity form. Unfortunately, na¨ıve modeling with for researchers and policy-makers to analyze the data aggregated data may significantly diminish and examine individual level inferences. However, in the accuracy of inferences at the individ- many domains, individual records are difficult to ob- ual level. This paper addresses the scenario tain. This particularly true in the healthcare industry where features are provided at the individual where protecting the privacy of patients restricts pub- level, but the target variables are only avail- lic access to much of the sensitive data. Therefore, able as histogram aggregates or order statis- in many cases, multiple Statistical Disclosure Limita- tics. We consider a limiting case of gener- tion (SDL) techniques are applied [9]. Of these, data alized linear modeling when the target vari- aggregation is the most widely used technique [5]. ables are only known up to permutation, and explore how this relates to permutation test- It is common for agencies to report both individual ing; a standard technique for assessing statis- level information for non-sensitive attributes together tical dependency. Based on this relationship, with the aggregated information in the form of sample we propose a simple algorithm to estimate statistics. -
Using Epidemiological Evidence in Tort Law: a Practical Guide Aleksandra Kobyasheva
Using epidemiological evidence in tort law: a practical guide Aleksandra Kobyasheva Introduction Epidemiology is the study of disease patterns in populations which seeks to identify and understand causes of disease. By using this data to predict how and when diseases are likely to arise, it aims to prevent the disease and its consequences through public health regulation or the development of medication. But can this data also be used to tell us something about an event that has already occurred? To illustrate, consider a case where a claimant is exposed to a substance due to the defendant’s negligence and subsequently contracts a disease. There is not enough evidence available to satisfy the traditional ‘but-for’ test of causation.1 However, an epidemiological study shows that there is a potential causal link between the substance and the disease. What is, or what should be, the significance of this study? In Sienkiewicz v Greif members of the Supreme Court were sceptical that epidemiological evidence can have a useful role to play in determining questions of causation.2 The issue in that case was a narrow one that did not present the full range of concerns raised by epidemiological evidence, but the court’s general attitude was not unusual. Few English courts have thought seriously about the ways in which epidemiological evidence should be approached or interpreted; in particular, the factors which should be taken into account when applying the ‘balance of probability’ test, or the weight which should be attached to such factors. As a result, this article aims to explore this question from a practical perspective. -
Meta-Analysis Using Individual Participant Data: One-Stage and Two-Stage Approaches, and Why They May Differ Danielle L
CORE Metadata, citation and similar papers at core.ac.uk Provided by Keele Research Repository Tutorial in Biostatistics Received: 11 March 2016, Accepted: 13 September 2016 Published online in Wiley Online Library (wileyonlinelibrary.com) DOI: 10.1002/sim.7141 Meta-analysis using individual participant data: one-stage and two-stage approaches, and why they may differ Danielle L. Burke*† Joie Ensor and Richard D. Riley Meta-analysis using individual participant data (IPD) obtains and synthesises the raw, participant-level data from a set of relevant studies. The IPD approach is becoming an increasingly popular tool as an alternative to traditional aggregate data meta-analysis, especially as it avoids reliance on published results and provides an opportunity to investigate individual-level interactions, such as treatment-effect modifiers. There are two statistical approaches for conducting an IPD meta-analysis: one-stage and two-stage. The one-stage approach analyses the IPD from all studies simultaneously, for example, in a hierarchical regression model with random effects. The two-stage approach derives aggregate data (such as effect estimates) in each study separately and then combines these in a traditional meta-analysis model. There have been numerous comparisons of the one-stage and two-stage approaches via theoretical consideration, simulation and empirical examples, yet there remains confusion regarding when each approach should be adopted, and indeed why they may differ. In this tutorial paper, we outline the key statistical methods for one-stage and two-stage IPD meta-analyses, and provide 10 key reasons why they may produce different summary results. We explain that most differences arise because of different modelling assumptions, rather than the choice of one-stage or two-stage itself. -
Analysis of Scientific Research on Eyewitness Identification
ANALYSIS OF SCIENTIFIC RESEARCH ON EYEWITNESS IDENTIFICATION January 2018 Patricia A. Riley U.S. Attorney’s Office, DC Table of Contents RESEARCH DOES NOT PROVIDE A FIRM FOUNDATION FOR JURY INSTRUCTIONS OF THE TYPE ADOPTED BY SOME COURTS OR, IN SOME INSTANCES, FOR EXPERT TESTIMONY ...................................................... 6 RESEARCH DOES NOT PROVIDE A FIRM FOUNDATION FOR JURY INSTRUCTIONS OF THE TYPE ADOPTED BY SOME COURTS AND, IN SOME INSTANCES, FOR EXPERT TESTIMONY .................................................... 8 Introduction ............................................................................................................................................. 8 Courts should not comment on the evidence or take judicial notice of contested facts ................... 11 Jury Instructions based on flawed or outdated research should not be given .................................. 12 AN OVERVIEW OF THE RESEARCH ON EYEWITNESS IDENTIFICATION OF STRANGERS, NEW AND OLD .... 16 Important Points .................................................................................................................................... 16 System Variables .................................................................................................................................... 16 Simultaneous versus sequential presentation ................................................................................... 16 Double blind, blind, blinded administration (unless impracticable ................................................... -
Learning to Personalize Medicine from Aggregate Data
medRxiv preprint doi: https://doi.org/10.1101/2020.07.07.20148205; this version posted July 8, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license . Learning to Personalize Medicine from Aggregate Data Rich Colbaugh Kristin Glass Volv Global Lausanne, Switzerland Abstract There is great interest in personalized medicine, in which treatment is tailored to the individual characteristics of pa- tients. Achieving the objectives of precision healthcare will require clinically-grounded, evidence-based approaches, which in turn demands rigorous, scalable predictive analytics. Standard strategies for deriving prediction models for medicine involve acquiring ‘training’ data for large numbers of patients, labeling each patient according to the out- come of interest, and then using the labeled examples to learn to predict the outcome for new patients. Unfortunate- ly, labeling individuals is time-consuming and expertise-intensive in medical applications and thus represents a ma- jor impediment to practical personalized medicine. We overcome this obstacle with a novel machine learning algo- rithm that enables individual-level prediction models to be induced from aggregate-level labeled data, which is read- ily-available in many health domains. The utility of the proposed learning methodology is demonstrated by: i.) lev- eraging US county-level mental health statistics to create a screening tool which detects individuals suffering from depression based upon their Twitter activity; ii.) designing a decision-support system that exploits aggregate clinical trials data on multiple sclerosis (MS) treatment to predict which therapy would work best for the presenting patient; iii.) employing group-level clinical trials data to induce a model able to find those MS patients likely to be helped by an experimental therapy. -
Good Statistical Practices for Contemporary Meta-Analysis: Examples Based on a Systematic Review on COVID-19 in Pregnancy
Review Good Statistical Practices for Contemporary Meta-Analysis: Examples Based on a Systematic Review on COVID-19 in Pregnancy Yuxi Zhao and Lifeng Lin * Department of Statistics, Florida State University, Tallahassee, FL 32306, USA; [email protected] * Correspondence: [email protected] Abstract: Systematic reviews and meta-analyses have been increasingly used to pool research find- ings from multiple studies in medical sciences. The reliability of the synthesized evidence depends highly on the methodological quality of a systematic review and meta-analysis. In recent years, several tools have been developed to guide the reporting and evidence appraisal of systematic reviews and meta-analyses, and much statistical effort has been paid to improve their methodological quality. Nevertheless, many contemporary meta-analyses continue to employ conventional statis- tical methods, which may be suboptimal compared with several alternative methods available in the evidence synthesis literature. Based on a recent systematic review on COVID-19 in pregnancy, this article provides an overview of select good practices for performing meta-analyses from sta- tistical perspectives. Specifically, we suggest meta-analysts (1) providing sufficient information of included studies, (2) providing information for reproducibility of meta-analyses, (3) using appro- priate terminologies, (4) double-checking presented results, (5) considering alternative estimators of between-study variance, (6) considering alternative confidence intervals, (7) reporting predic- Citation: Zhao, Y.; Lin, L. Good tion intervals, (8) assessing small-study effects whenever possible, and (9) considering one-stage Statistical Practices for Contemporary methods. We use worked examples to illustrate these good practices. Relevant statistical code Meta-Analysis: Examples Based on a is also provided. -
Chiquan Guo the University of Texas Rio Grande Valley Department of Marketing (956) 665-7339 Email: [email protected]
Dr. Chiquan Guo The University of Texas Rio Grande Valley Department of Marketing (956) 665-7339 Email: [email protected] Education PhD, Southern Illinois University - Carbondale, 2002. Major: Business Administration Title: Market Orientation and Customer Satisfaction: An Empirical Investigation MBA, University of Wisconsin - Oshkosh, 1996. Major: Business Administration BA, University of Wisconsin - Green Bay, 1994. Major: Economics Employment History Academic - Post-Secondary Associate Professor of Marketing, The University of Texas Rio Grande Valley. (September 2015 - Present). Licensures and Certifications UTRGV's Sustainable Faculty Development Webinar Sessions, The University of Texas Rio Grande Valley Office for Sustainability. (May 2019 - Present). QM Rubric Update Sixth Edition (RU), Quality Matters (QM). (January 8, 2019 - Present). Study of Exchange: Comprehension of Local History and Culture, B3 Institure & Center for Teaching Excellence at The University of Texas Rio Grande Valley. (2018 - Present). Independent Applying the QM Rubric (APPQMR), Quality Matters (QM). (December 9, 2016 - Present). Majors Fair, The University of Texas-Pan American. (September 23, 2014 - Present). Teaching Excellence, College of Business Administration at The University of Texas-Pan American. (May 2014 - Present). Majors Fair, Coordinator of Majors Fair Committee at The University of Texas Rio Grande Valley. (September 24, 2013 - Present). Teaching Online Certification - Blackboard Learn, Center for Online Learning, Teaching & Technology at The University of Texas-Pan American. (April 8, 2013 - Present). Responsible Conduct of Research; Social and Behavioral Responsible Conduct of Research Course 1; 1 - Basic Course, CITI Program. (February 20, 2019 - February 19, 2023). Report Generated on September 13, 2021 Page 1 of 8 Basic/Refresher Course - Human Subjects Research; Social Behavioral Research Investigators and Key Personnel; 1 - Basic Course, CITI Program. -
Probability, Explanation, and Inference: a Reply
Alabama Law Scholarly Commons Working Papers Faculty Scholarship 3-2-2017 Probability, Explanation, and Inference: A Reply Michael S. Pardo University of Alabama - School of Law, [email protected] Ronald J. Allen Northwestern University - Pritzker School of Law, [email protected] Follow this and additional works at: https://scholarship.law.ua.edu/fac_working_papers Recommended Citation Michael S. Pardo & Ronald J. Allen, Probability, Explanation, and Inference: A Reply, (2017). Available at: https://scholarship.law.ua.edu/fac_working_papers/4 This Working Paper is brought to you for free and open access by the Faculty Scholarship at Alabama Law Scholarly Commons. It has been accepted for inclusion in Working Papers by an authorized administrator of Alabama Law Scholarly Commons. Probability, Explanation, and Inference: A Reply Ronald J. Allen Michael S. Pardo 11 INTERNATIONAL JOURNAL OF EVIDENCE AND PROOF 307 (2007) This paper can be downloaded without charge from the Social Science Research Network Electronic Paper Collection: http://ssrn.com/abstract=2925866 Electronic copy available at: https://ssrn.com/abstract=2925866 PROBABILITY, EXPLANATION AND INFERENCE: A REPLY Probability, explanation and inference: a reply By Ronald J. Allen* and Wigmore Professor of Law, Northwestern University; Fellow, Procedural Law Research Center, China Political Science and Law University Michael S. Pardo† Assistant Professor, University of Alabama School of Law he inferences drawn from legal evidence may be understood in both probabilistic and explanatory terms. Consider evidence that a criminal T defendant confessed while in police custody. To evaluate the strength of this evidence in supporting the conclusion that the defendant is guilty, one could try to assess the probability that guilty and innocent persons confess while in police custody. -
Yubin Zeng Resume 1
CURRICULUM VITAE Yubin Zeng Department of Water Quality Engineering, Wuhan University No.8 East Lake Road South, Wuchang District, 430072, Wuhan, China PERSONAL Position: Associate professor, vice director of Water Quality Engineering E-mail: [email protected]; [email protected] Personal webpage: http://pmc.whu.edu.cn/teachers/185.html EDUCATION B. Eng. – Department of Chemical Engineering, East China University of Science and Technology, China (1991). M. Sc. – Department of Applied Chemistry, Huazhong University of Science and Technology, China (2000). Ph. D. – Department of Environmental Science and Engineering, Huazhong University of Science and Technology, China (2007). Post-doctor fellowship – Department of Civil and Environmental Engineering, Seoul National University, Korea (2009). TEACHING 1. Separation Processes of Chemical Engineering (to graduate students) 2. Theory and Technology of Water Treatment (to undergraduate students) 3. Water Treatment Experiment (to undergraduate students) 4. Wastewater Reuse Technology (to undergraduate students) RESEARCH 1 Research interests 1. Water and wastewater treatment for reuse. 2. Environmental nanomaterials and technology. 3. Remediation of ground and underground water. Research in progress 1. Funds supported from industry. “Treatment and reuse of high salt wastewater with high temperature from oil field”, Project Leader. 2. Funds supported from industry. “Biologic treatment and discharge of wastewater from heavy oil’ process and production”, Project Leader. 3. Open Funds for State Key Lab of Biogeology and Environmental Geology, China (GBL21311): “Study on remediation of chlorinated hydrocarbons by nano composite materials/microorganism”, Project Leader. 4. National planning project on innovation and entrepreneurship training of China University (201410486051): “Research on mechanism and application on organic molecule modification of nano core-shell magnetic composite”, Project Leader. -
Reconciling Household Surveys and National Accounts Data Using a Cross Entropy Estimation Method
TMD DISCUSSION PAPER NO. 50 RECONCILING HOUSEHOLD SURVEYS AND NATIONAL ACCOUNTS DATA USING A CROSS ENTROPY ESTIMATION METHOD Anne-Sophie Robilliard Sherman Robinson International Food Policy Research Institute Trade and Macroeconomics Division International Food Policy Research Institute 2033 K Street, N.W. Washington, D.C. 20006, U.S.A. November 1999 (Revised January 2001) TMD Discussion Papers contain preliminary material and research results, and are circulated prior to a full peer review in order to stimulate discussion and critical comment. It is expected that most Discussion Papers will eventually be published in some other form, and that their content may also be revised. This paper is available at http://www.cgiar.org/ifpri/divs/tmd/dp/papers/dp50.pdf Abstract This paper presents an approach to reconciling household surveys and national accounts data that starts from the assumption that the macro data represent control totals to which the household data must be reconciled, but the macro aggregates may be measured with error. The economic data gathered in the household survey are assumed to be accurate, or have been adjusted to be accurate. Given these assumptions, the problem is how to use the additional information provided by the national accounts data to re-estimate the household weights used in the survey so that the survey results are consistent with the aggregate data, while simultaneously estimating the errors in the aggregates. The estimation approach represents an efficient “information processing rule” using an estimation criterion based on an entropy measure of information. The survey household weights are treated as a prior. New weights are estimated that are close to the prior using a cross-entropy metric and that are also consistent with the additional information. -
Patents & Legal Expenditures
Patents & Legal Expenditures Christopher J. Ryan, Jr. & Brian L. Frye* I. INTRODUCTION ................................................................................................ 577 A. A Brief History of University Patents ................................................. 578 B. The Origin of University Patents ........................................................ 578 C. University Patenting as a Function of Patent Policy Incentives ........ 580 D. The Business of University Patenting and Technology Transfer ....... 581 E. Trends in Patent Litigation ................................................................. 584 II. DATA AND ANALYSIS .................................................................................... 588 III. CONCLUSION ................................................................................................. 591 I. INTRODUCTION Universities are engines of innovation. To encourage further innovation, the federal government and charitable foundations give universities grants in order to enable university researchers to produce the inventions and discoveries that will continue to fuel our knowledge economy. Among other things, the Bayh-Dole Act of 1980 was supposed to encourage additional innovation by enabling universities to patent inventions and discoveries produced using federal funds and to license those patents to private companies, rather than turning their patent rights over to the government. The Bayh-Dole Act unquestionably encouraged universities to patent inventions and license their patents.