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This Document Is the Property of Bayer AG And/Or and and regime. AG Bayer property protectionpublishing of contents its parties.data therefore and/oror affiliates. property intellectualthird may its as the of and is regulatory owner. a document any such its reproductiondocument of owner this Executive Summary under of Safety Assessment of Roundup Ready rightsthe this documentand/or of rights Using modern biotechnology, Monsanto Company has developed Roundup Ready to of fall use corn plants that confer tolerance to the agricultural herbicides, by the production of the glyphosate This may distribution,and enolpyruvylshikimate rights owner plants by inhibiting the enzyme EPSPS. This enzyme cataly subject shikimic acid pathway for the biosynthesis of aromatic amino acids in plants and be the violate microorganisms, and its inhibition leads to the lack of growth in plants. The CP4 copy of EPSPS proteins have a low affinity for glyphosate compared to the Event NK603 document and EPSPS enzyme. Thus, when corn plants expressing the CP4 EPSPS proteins are may publication,exploitation treated with glyphosate, the plants continue to grow. The continued action of the It tolerant CP4 EPSPS enzyme provides the plant’s need for aromatic acids. Aromatic this -3 any amino ac - activity in plants and contributes to the low mammalianphosphate toxicity synthase of glyphosate. (EPSPS) Two proteins. Glyphosate kills permission copies of the prohibited glyphosate, the active ingredient in Roundup Roundup Ready cornid biosynthesis event is not present in animals. This explains the selective the be soil bacterium ® commercial tolerant EPSPS protein. Corn Furthermore,any The food and feed safety of cp4corn epsps event NK603 was established based upon: the Consequently,without evaluation of CP4 EPSPS of plants, including those usedAgrobacterium for foods; the low dietary exposure to CP4 EPSPS; the rapid digestibility of CP4 EPSPS; and the lack geneof toxicity were introducedor allergenicity into theof EPSPSscorn genome to produce generally and by saf corn event NK603 compared to conventional corn was demonstrated by analyses of key -tolerant CP4 5 NK603. The nutrients including protein, fat, carbohydrates, moisture, amino acids, fatty acids, and minerals. Nutrit zes a critical step in the was confirmed by evaluation of the feed performance in broilersp. chickens strain and a rat feeding study, which included clinical and histological evaluations. The environmental impact of Roundup R activity and homology to EPSPScp4 epspsproteins present in a diversity - ® ® volunteer corn is infrequent and easily managedety studies in theof the farmer’s expressed field. CP4 The EPSPS results CP4 proteins.of all The equivalence of these studies demonstrate that corn event NK603 is comparable to traditional corn with ional equivalence of corn event NK603 compared to conventional corn wild respect to fo encodes for the naturally glyphosate gene derived from the common -type od, feed and environmentaleady corn safety.is comparable to conventional corn. Glyphosate - -tolerant and and regime. AG Bayer property protectionpublishing of contents its parties.data therefore and/oror affiliates. property intellectualthird may its as the of and is regulatory owner. a document any such its reproductiondocument owner this of under of rightsthe this documentand/or of rights to of fall use the This may distribution,and rights owner subject be the violate copy of and may documentpublication, It exploitation this any permission prohibited the commercial be Furthermore,any Consequently,without Monsanto Company is a member of Excellence Through Stewardship® (ETS). accordance with ETS Product Launch Stewardship Guidance, and in compliance with Monsanto’s Policy for Commercialization of Biotechnology functioning regulatory systems. Any crop or material produced from this product can only be exported to, or used, processed o countries where all necessary regulatory approvals have been granted. It is a violation of national and international law to material containing biotech traits across boundaries into nations where import is not permitted. Growers should talk to handler or product purchaser to confirm their buying position for this product. Excellence Through Stewardship® is a register - trademark of Excellence ThroughDerived Stewardsh Plant Products in Commodity Crops. This product has been approved for import into key export markets with ALWAYS READ AND FOLLOW PESTICIDE LABEL DIRECTIONS. confer tolerance to glyphosate. trademark of Bayer Group. ©2019 Bayer Group. All rights reserved. This document is protected under national and international copyright law and are for use only by the regulatory authority to which it has been submitted by Monsanto Company and its affiliates, collectiv “Bayer Group”, and only in support of actions requested by Bayer Group. posting, of this document and the materials described in or accompanying this document, without prior consent of Monsanto Company, is strictly prohibited; except that Monsanto Company hereby grant under applicable law or regulation. are owned by Bayer Group, which has filed for or been granted pat accompanying materials, Monsanto Company and the Bayer GroupGlyphosate do not grant any party or entity any right or license to the information, material or intellectual property described or contained in ip. will kill crops that are not tolerant to glyphosate. Roundup Ready® is a registered Monsanto products are commercialized in The intellectual property, information and materials described in or accompanying this document Roundup Ready® 2 T treaties. This document and any accompanying material Any other use, copying, or transmission, including internet ents on those materials. By submitting this document and any s such consent to the regulatory authority where echnologyrequired move their grain r s this submission. old in contains genes that ed ely .
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