A Critique of Structural Vars Using Real Business Cycle Theory∗
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Design and Implementation of N-Of-1 Trials: a User's Guide
Design and Implementation of N-of-1 Trials: A User’s Guide N of 1 The Agency for Healthcare Research and Quality’s (AHRQ) Effective Health Care Program conducts and supports research focused on the outcomes, effectiveness, comparative clinical effectiveness, and appropriateness of pharmaceuticals, devices, and health care services. More information on the Effective Health Care Program and electronic copies of this report can be found at www.effectivehealthcare.ahrq. gov. This report was produced under contract to AHRQ by the Brigham and Women’s Hospital DEcIDE (Developing Evidence to Inform Decisions about Effectiveness) Methods Center under Contract No. 290-2005-0016-I. The AHRQ Task Order Officer for this project was Parivash Nourjah, Ph.D. The findings and conclusions in this document are those of the authors, who are responsible for its contents; the findings and conclusions do not necessarily represent the views ofAHRQ or the U.S. Department of Health and Human Services. Therefore, no statement in this report should be construed as an official position of AHRQ or the U.S. Department of Health and Human Services. Persons using assistive technology may not be able to fully access information in this report. For assistance contact [email protected]. The following investigators acknowledge financial support: Dr. Naihua Duan was supported in part by NIH grants 1 R01 NR013938 and 7 P30 MH090322, Dr. Heather Kaplan is part of the investigator team that designed and developed the MyIBD platform, and this work was supported in part by Cincinnati Children’s Hospital Medical Center. Dr. Richard Kravitz was supported in part by National Institute of Nursing Research Grant R01 NR01393801. -
Generalized Linear Models for Aggregated Data
Generalized Linear Models for Aggregated Data Avradeep Bhowmik Joydeep Ghosh Oluwasanmi Koyejo University of Texas at Austin University of Texas at Austin Stanford University [email protected] [email protected] [email protected] Abstract 1 Introduction Modern life is highly data driven. Datasets with Databases in domains such as healthcare are records at the individual level are generated every routinely released to the public in aggregated day in large volumes. This creates an opportunity form. Unfortunately, na¨ıve modeling with for researchers and policy-makers to analyze the data aggregated data may significantly diminish and examine individual level inferences. However, in the accuracy of inferences at the individ- many domains, individual records are difficult to ob- ual level. This paper addresses the scenario tain. This particularly true in the healthcare industry where features are provided at the individual where protecting the privacy of patients restricts pub- level, but the target variables are only avail- lic access to much of the sensitive data. Therefore, able as histogram aggregates or order statis- in many cases, multiple Statistical Disclosure Limita- tics. We consider a limiting case of gener- tion (SDL) techniques are applied [9]. Of these, data alized linear modeling when the target vari- aggregation is the most widely used technique [5]. ables are only known up to permutation, and explore how this relates to permutation test- It is common for agencies to report both individual ing; a standard technique for assessing statis- level information for non-sensitive attributes together tical dependency. Based on this relationship, with the aggregated information in the form of sample we propose a simple algorithm to estimate statistics. -
Meta-Analysis Using Individual Participant Data: One-Stage and Two-Stage Approaches, and Why They May Differ Danielle L
CORE Metadata, citation and similar papers at core.ac.uk Provided by Keele Research Repository Tutorial in Biostatistics Received: 11 March 2016, Accepted: 13 September 2016 Published online in Wiley Online Library (wileyonlinelibrary.com) DOI: 10.1002/sim.7141 Meta-analysis using individual participant data: one-stage and two-stage approaches, and why they may differ Danielle L. Burke*† Joie Ensor and Richard D. Riley Meta-analysis using individual participant data (IPD) obtains and synthesises the raw, participant-level data from a set of relevant studies. The IPD approach is becoming an increasingly popular tool as an alternative to traditional aggregate data meta-analysis, especially as it avoids reliance on published results and provides an opportunity to investigate individual-level interactions, such as treatment-effect modifiers. There are two statistical approaches for conducting an IPD meta-analysis: one-stage and two-stage. The one-stage approach analyses the IPD from all studies simultaneously, for example, in a hierarchical regression model with random effects. The two-stage approach derives aggregate data (such as effect estimates) in each study separately and then combines these in a traditional meta-analysis model. There have been numerous comparisons of the one-stage and two-stage approaches via theoretical consideration, simulation and empirical examples, yet there remains confusion regarding when each approach should be adopted, and indeed why they may differ. In this tutorial paper, we outline the key statistical methods for one-stage and two-stage IPD meta-analyses, and provide 10 key reasons why they may produce different summary results. We explain that most differences arise because of different modelling assumptions, rather than the choice of one-stage or two-stage itself. -
Learning to Personalize Medicine from Aggregate Data
medRxiv preprint doi: https://doi.org/10.1101/2020.07.07.20148205; this version posted July 8, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license . Learning to Personalize Medicine from Aggregate Data Rich Colbaugh Kristin Glass Volv Global Lausanne, Switzerland Abstract There is great interest in personalized medicine, in which treatment is tailored to the individual characteristics of pa- tients. Achieving the objectives of precision healthcare will require clinically-grounded, evidence-based approaches, which in turn demands rigorous, scalable predictive analytics. Standard strategies for deriving prediction models for medicine involve acquiring ‘training’ data for large numbers of patients, labeling each patient according to the out- come of interest, and then using the labeled examples to learn to predict the outcome for new patients. Unfortunate- ly, labeling individuals is time-consuming and expertise-intensive in medical applications and thus represents a ma- jor impediment to practical personalized medicine. We overcome this obstacle with a novel machine learning algo- rithm that enables individual-level prediction models to be induced from aggregate-level labeled data, which is read- ily-available in many health domains. The utility of the proposed learning methodology is demonstrated by: i.) lev- eraging US county-level mental health statistics to create a screening tool which detects individuals suffering from depression based upon their Twitter activity; ii.) designing a decision-support system that exploits aggregate clinical trials data on multiple sclerosis (MS) treatment to predict which therapy would work best for the presenting patient; iii.) employing group-level clinical trials data to induce a model able to find those MS patients likely to be helped by an experimental therapy. -
Good Statistical Practices for Contemporary Meta-Analysis: Examples Based on a Systematic Review on COVID-19 in Pregnancy
Review Good Statistical Practices for Contemporary Meta-Analysis: Examples Based on a Systematic Review on COVID-19 in Pregnancy Yuxi Zhao and Lifeng Lin * Department of Statistics, Florida State University, Tallahassee, FL 32306, USA; [email protected] * Correspondence: [email protected] Abstract: Systematic reviews and meta-analyses have been increasingly used to pool research find- ings from multiple studies in medical sciences. The reliability of the synthesized evidence depends highly on the methodological quality of a systematic review and meta-analysis. In recent years, several tools have been developed to guide the reporting and evidence appraisal of systematic reviews and meta-analyses, and much statistical effort has been paid to improve their methodological quality. Nevertheless, many contemporary meta-analyses continue to employ conventional statis- tical methods, which may be suboptimal compared with several alternative methods available in the evidence synthesis literature. Based on a recent systematic review on COVID-19 in pregnancy, this article provides an overview of select good practices for performing meta-analyses from sta- tistical perspectives. Specifically, we suggest meta-analysts (1) providing sufficient information of included studies, (2) providing information for reproducibility of meta-analyses, (3) using appro- priate terminologies, (4) double-checking presented results, (5) considering alternative estimators of between-study variance, (6) considering alternative confidence intervals, (7) reporting predic- Citation: Zhao, Y.; Lin, L. Good tion intervals, (8) assessing small-study effects whenever possible, and (9) considering one-stage Statistical Practices for Contemporary methods. We use worked examples to illustrate these good practices. Relevant statistical code Meta-Analysis: Examples Based on a is also provided. -
A Factor-Augmented Vector Autoregression Analysis of Business Cycle Synchronization in East Asia and Implications for a Regional Currency Union
A Service of Leibniz-Informationszentrum econstor Wirtschaft Leibniz Information Centre Make Your Publications Visible. zbw for Economics Huh, Hyeon-seung; Kim, David; Kim, Won Joong; Park, Cyn-Young Working Paper A Factor-Augmented Vector Autoregression Analysis of Business Cycle Synchronization in East Asia and Implications for a Regional Currency Union ADB Economics Working Paper Series, No. 385 Provided in Cooperation with: Asian Development Bank (ADB), Manila Suggested Citation: Huh, Hyeon-seung; Kim, David; Kim, Won Joong; Park, Cyn-Young (2013) : A Factor-Augmented Vector Autoregression Analysis of Business Cycle Synchronization in East Asia and Implications for a Regional Currency Union, ADB Economics Working Paper Series, No. 385, Asian Development Bank (ADB), Manila, http://hdl.handle.net/11540/1985 This Version is available at: http://hdl.handle.net/10419/109498 Standard-Nutzungsbedingungen: Terms of use: Die Dokumente auf EconStor dürfen zu eigenen wissenschaftlichen Documents in EconStor may be saved and copied for your Zwecken und zum Privatgebrauch gespeichert und kopiert werden. personal and scholarly purposes. Sie dürfen die Dokumente nicht für öffentliche oder kommerzielle You are not to copy documents for public or commercial Zwecke vervielfältigen, öffentlich ausstellen, öffentlich zugänglich purposes, to exhibit the documents publicly, to make them machen, vertreiben oder anderweitig nutzen. publicly available on the internet, or to distribute or otherwise use the documents in public. Sofern die Verfasser die Dokumente unter Open-Content-Lizenzen (insbesondere CC-Lizenzen) zur Verfügung gestellt haben sollten, If the documents have been made available under an Open gelten abweichend von diesen Nutzungsbedingungen die in der dort Content Licence (especially Creative Commons Licences), you genannten Lizenz gewährten Nutzungsrechte. -
Interdependence of Us Industry Sectors Using Vector Autoregression
INTERDEPENDENCE OF US INDUSTRY SECTORS USING VECTOR AUTOREGRESSION BY SUWODI DUTTA BORDOLOI SUBMITTED TO THE FACULTY OF WORCESTER POLYTECHNIC INSTITUTE IN PARTIAL FULFILLMENT OF THE REQUIREMENT FOR THE DEGREE OF MASTERS OF SCIENCE IN FINANCIAL MATHEMATICS . APPROVED: DR. WANLI ZHAO (D EPARTMENT OF MANAGEMENT ), ADVISOR DR. DOMOKOS VERMES (D EPARTMENT OF MATHEMATICAL SCIENCES ), ADVISOR DR. BOGDAN M. VERNESCU (H EAD OF MATHEMATICAL SCIENCES DEPARTMENT ) ACKNOWLEDGEMENT I would like to express my deep gratitude to my supervisors Dr. Wanli Zhao from the Department of Management and Dr. Domokos Vermes of Department of Mathematical Sciences, without their support, guidance and constant motivation this project would not have been possible. I would like to sincerely thank them for allowing me to learn from their knowledge and experience and for their patience and encouragement which helped me to get through difficult times. I would like to thank the Professors in the Mathematics Department: Dr. Marcel Blais, Dr. Hasanjan Sayit, Dr. Balgobin Nandram, Dr. Jayson D. Wilbur, Dr. Darko Volkov, Dr. Bogdan M. Vernescu and Dr. Suzanne L.Weekes. I thank the administrative staff members of the Mathematics Department: Ellen Mackin, Deborah M. K. Riel, Rhonda Podell and Mike Malone. I appreciate all fellow students in the Mathematics Department who shared their expertise, experience, happiness and fun. Special thanks to my family for the moral support they provided at all times. i CONTENTS 1. Introduction 1 2. Literature Review 7 3. Methodology 11 4. Data Description 17 5. Results 19 5.1 Descriptive Statistics 19 5.2 Findings based on VAR 21 5.2.1 Daily returns portfolio 21 5.2.2 Weekly returns portfolio 24 5.2.3 Findings on subsamples of peaceful and volatile periods 25 5.3 Comparison of VAR results of all data sets 26 5.4 Summary 30 6. -
Chapter 5. Structural Vector Autoregression
Chapter 5. Structural Vector Autoregression Contents 1 Introduction 1 2 The structural moving average model 1 2.1 The impulse response function . 2 2.2 Variance decomposition . 3 3 The structural VAR representation 4 3.1 Connection between VAR and VMA . 5 3.2 The invertibility requirement . 5 4 Identi…cation of the structural VAR 8 4.1 The order condition . 9 4.2 What shouldn’tbe done . 9 4.3 A common normalization that provides n(n - 1)/2 restrictions . 11 4.4 Identi…cation through short run restrictions . 11 4.5 Identi…cation through long run restrictions . 12 5 Estimation and inference 13 5.1 Estimating exactly identi…ed models . 13 5.2 Estimating overly identi…ed models . 13 5.3 Inference . 14 6 Structural VAR versus fully speci…ed economic models 14 1. Introduction Following the work of Sims (1980), vector autoregressions have been extensively used by economists for data description, forecasting and structural inference. The discussion here focuses on structural inference. The key idea, as put forward by Sims (1980), is to estimate a model with minimal parametric restrictions and then subsequently test economic hypothesis based on such a model. This idea has attracted a great deal of attention since it promises to deliver an alternative framework to testing economic theory without relying on elaborately parametrized dynamic general equilibrium models. The material in this chapter is based on Watson (1994) and Fernandez-Villaverde, Rubio-Ramirez, Sargent and Watson (2007). We begin the discussion by introducing the structural moving average model, and show that this model provides answers to the “impulse” and “propagation” questions often asked by macroeconomists. -
Reconciling Household Surveys and National Accounts Data Using a Cross Entropy Estimation Method
TMD DISCUSSION PAPER NO. 50 RECONCILING HOUSEHOLD SURVEYS AND NATIONAL ACCOUNTS DATA USING A CROSS ENTROPY ESTIMATION METHOD Anne-Sophie Robilliard Sherman Robinson International Food Policy Research Institute Trade and Macroeconomics Division International Food Policy Research Institute 2033 K Street, N.W. Washington, D.C. 20006, U.S.A. November 1999 (Revised January 2001) TMD Discussion Papers contain preliminary material and research results, and are circulated prior to a full peer review in order to stimulate discussion and critical comment. It is expected that most Discussion Papers will eventually be published in some other form, and that their content may also be revised. This paper is available at http://www.cgiar.org/ifpri/divs/tmd/dp/papers/dp50.pdf Abstract This paper presents an approach to reconciling household surveys and national accounts data that starts from the assumption that the macro data represent control totals to which the household data must be reconciled, but the macro aggregates may be measured with error. The economic data gathered in the household survey are assumed to be accurate, or have been adjusted to be accurate. Given these assumptions, the problem is how to use the additional information provided by the national accounts data to re-estimate the household weights used in the survey so that the survey results are consistent with the aggregate data, while simultaneously estimating the errors in the aggregates. The estimation approach represents an efficient “information processing rule” using an estimation criterion based on an entropy measure of information. The survey household weights are treated as a prior. New weights are estimated that are close to the prior using a cross-entropy metric and that are also consistent with the additional information. -
Vector Auto Regression Model of Inflation in Mongolia
con d E om Ulziideleg, Bus Eco J 2017, 8:4 n ic a s : s J s o DOI 10.4172/2151-6219.1000330 e u n r i Business and Economics n s a u l B ISSN: 2151-6219 Journal Research Article Open Access Vector Auto Regression Model of Inflation in Mongolia Taivan Ulziideleg* Senior Supervisor, Supervision Department, Bank of Mongolia (the Central Bank), Ulaanbaatar, Mongolia Abstract This paper investigates the relationship between inflation, real money, exchange rate and real output based on data from 1997 to 2005. Vector auto regression analysis presented to establish the relationship. The results of the research indicate that the dynamics of inflation are affected by previous month exchange rate changes and money growth. It means that there is a need to lessen the influence of exchange rate expectation on economy and to improve efficiency of management of the monetary instrument. Keywords: Inflation; Monetary; Consumption; Management; to investigate the determinants of inflation in those countries. They Economy show that foreign prices and the persistence of inflation were the key elements of inflation. Introduction Kalra [6] studies inflation and money demand in Albania, which When discussing the causes of inflation in developing countries is a small transition economy the size of Mongolia in terms of GDP one finds that the literature contains two major competing hypotheses. between 1993-1997. His model supports the claim that determinants First, there is the monetarist model, which sees inflation as a monetary of inflation and money demand in transition economies are similar to phenomenon, the control of which requires a control of the money those in market economies. -
Supervised Learning by Training on Aggregate Outputs
Supervised Learning by Training on Aggregate Outputs David R. Musicant, Janara M. Christensen, Jamie F. Olson Department of Computer Science Carleton College Northfield, MN [email protected], [email protected], [email protected] Abstract black carbon (BC) associated with an individual aerosol particle. While SPMS data provides detailed mass spectra Supervised learning is a classic data mining problem for individual aerosol particles, these spectra are not quanti- where one wishes to be be able to predict an output value tative enough to allow one to precisely identify the amount associated with a particular input vector. We present a new of BC present in a particle. On the other hand, filter-based twist on this classic problem where, instead of having the machines can collect quantitative BC data, but in aggregate training set contain an individual output value for each in- form. These devices allow one to determine how much put vector, the output values in the training set are only BC has been observed in aggregate over a particular time given in aggregate over a number of input vectors. This span, typically on the order of an hour. SPMS data, on the new problem arose from a particular need in learning on other hand, may be collected for individual particles (non- mass spectrometry data, but could easily apply to situations aggregate data) many times per minute. Our goal is to be when data has been aggregated in order to maintain pri- able to predict the quantity of BC present in an individual vacy. We provide a formal description of this new prob- aerosol particle. -
Census Aggregate Data Workshop – 17 February 2015 • Ukdataservice.Ac.Uk/News-And-Events/Events
2011 Census – aggregate data Richard Wiseman Justin Hayes Webinar January 2015 2011 Census – aggregate data The webinar will begin at 2pm • You now have a menu in the top right corner of your screen. • The red button with a white arrow allows you to expand and contract the webinar menu, in which you can write questions/comments. • We won’t have time to answer questions while we are presenting, but will answer them at the end • You will be on mute throughout – we can’t hear you. Welcome Some introductions… Richard Wiseman UK Data Service Mimas, Jisc Justin Hayes UK Data Service Mimas, Jisc Can you hear us? If you can’t hear us • Check your speakers/headset • Check your volume • Use the phone number in your invitation to call in • The webinar is being recorded - we’ll send a link Webinar structure • 30 minute presentation • 20 minutes for questions and answers • Finish by 2.50pm • Please use chat facility to ask questions or let us know of any problems • Some questions for the audience during presentation Presentation content • The UK Data Service • UK Data Service Census Support • Census background • Aggregate data • Geographies • InFuse • Demo • Data / geography model • Next release • Future plans The UK Data Service • Funded by the ESRC, integrating several previous resources • A single, comprehensive and integrated point of access to a wide range of social science data • Support, training and guidance • ukdataservice.ac.uk UK Data Service Census Support • A specialist unit of the UK Data Service • Access to, and support for use of data