Accidental Heart Murmurs Doi: 10.5455/Medarh.2017.71.284-287 Edin Begic1, Zijo Begic2 MED ARCH

Total Page:16

File Type:pdf, Size:1020Kb

Accidental Heart Murmurs Doi: 10.5455/Medarh.2017.71.284-287 Edin Begic1, Zijo Begic2 MED ARCH REVIEW Accidental Heart Murmurs doi: 10.5455/medarh.2017.71.284-287 Edin Begic1, Zijo Begic2 MED ARCH. 2017 AUG; 71(4): 284-287 RECEIVED: JUN 20, 2017 | ACCEPTED: AUG 01, 2017 ABSTRACT Introduction: Accidental murmurs occur in anatomically and physiologically normal heart. Ac- cidental (innocent) murmurs have their own clearly defined clinical characteristics (asymp- tomatic, they require minimal follow-up care). Aim: To point out the significance of ausculta- 1Faculty of Medicine, Sarajevo School of Science and tion of the heart in the differentiation of heart murmurs and show clinical characteristics of Technology, Sarajevo, Bosnia and Herzegovina accidental heart murmurs. Material and methods: Article presents review of literature which 2Pediatric Clinic, University Clinical Center Sarajevo, deals with the issue of accidental heart murmurs in the pediatric cardiology. Results: In the Sarajevo, Bosnia and Herzegovina group of accidental murmurs we include classic vibratory parasternal-precordial Stills mur- mur, pulmonary ejection murmur, the systolic murmur of pulmonary flow in neonates, venous Corresponding author: Edin Begic, MD. Faculty of hum, carotid bruit, Potaine murmur, benign cephalic murmur and mammary souffle. Con- Medicine, Sarajevo School of Science and Technology, Sarajevo, Bosnia and Herzegovina. ORCID ID: http:// clusion: Accidental heart murmurs are revealed by auscultation in over 50% of children and www.orcid.org/0000-0001-6842-262X. E-mail: youth, with a peak occurrence between 3-6 years or 8-12 years of life. Reducing the frequency [email protected]. of murmurs in the later period can be related to poor conduction of the murmur, although the disappearance of murmur in principle is not expected. It is the most common reason of cardiac treatment of the child, and is a common cause of unreasonable concern of parents. Keywords: heart murmurs, accidental heart murmurs, heart auscultation. 1. INTRODUCTION vascular structure. The pathologic Heart murmurs can be organic substrate is a change from laminar (sign of heart disease) and inorgan- to turbulent flow. Incomplete open- ic (usually called innocent; basically ing of the aortic valve during systole divided into accidental and function- gives a triangular appearance of the al) (1). Accidental murmurs occur aortic valve lumen and tension of the in anatomically and physiologically valve, and thus converting laminar normal heart. Some authors may dif- blood flow to turbulent flow with the fer them from functional (murmurs vibration of valves and surrounding occurring in diseases which second- wall structures (1, 2). The transfer of arily affect the heart), but they are valve vibrations in the wall caused often involved in group of common by tribulation, probably represents innocent murmurs. With sufficient the physical background for etiolo- knowledge, it is possible to differ- gy of these murmurs. This change is entiate accidental and functional not only developed because of tri- murmur, just by auscultation. The gonidation (inconsistency or vola- localisation of accidental murmurs tility) of the valve, but also because is distributed in the precordium, of the flow of the blood through most often with left edge of ster- large vessels, which vary in size and num. Accidental (innocent) mur- diameter. Insufficient elasticity of murs have their own clearly defined valves leads to the incomplete open- clinical characteristics (asymptom- ing of the pulmonic or aortic valve, atic, they require minimal follow-up with a so-called triangular form of care) (1). They occur in anatomical- valve opening, which leads to tur- ly and physiologically normal heart. bulence outside the normal laminar They are called innocent, harmless, flow and flickering/trembling of the physiological, irrelevant, evolving, valve, which produces the murmur. benign, habitual, infantile, growth When they appear on semilunar murmurs, accidental, non-patho- valves (pulmonary and aortic valve), logical, non-organic, normal, false, for the development of murmur meaningless, ‘’functional’’, supine the tendon fibers of atrioventricu- © 2017 Edin Begic, Zijo Begic position murmurs, nonsignificant, lar valves are primarily responsible transitory, dynamic. Their place of (3, 4). The common background for This is an Open Access article distributed under the origin may not be the same, but they development of accidental murmurs terms of the Creative Commons Attribution Non- Commercial License (http://creativecommons.org/ are most commonly associated with presents interaction of turbulency, licenses/by-nc/4.0/) which permits unrestricted non- aortic and pulmonary valve (trigo- vibrations of valves and limited di- commercial use, distribution, and reproduction in any nodation with systole) and turbu- mensions of wall structures. Today it medium, provided the original work is properly cited. lent bloodflow within cardiac and is possible with echocardiographical 284 REVIEW | MED ARCH. 2017 AUG; 71(4): 284-287 Accidental Heart Murmurs aproach to visualise the symmetry within the structure and abnormal heart positions (7, 8). It is seen in school- of pulmonary and aortic valve (bicuspid, instead of tri- aged kids, and puberty and probably developed due to cuspid semilunar valves). Probably the most common normal turbulency of blood to the pulmonary valve. It is places for development of accidental murmurs are tend- less common than Still’s murmur, best heard in second inious fibers (chorde tendinae) of atrioventricular valves, and third intercostal space on the left, in lying position, so-called atypical or accessory tendinious fibers. Finally, probably due to increased stroke volume and ejection there are also tendinious fibers (chorde tendinae) which of blood. This murmur shows a significant increase of are completely atypical and are present in the left ventri- incidence, in deference to Still murmur, in cases of in- cle, and they do not communicate with atrioventricular creased cardiac output, but we should keep in mind that valve. both types of murmurs are increasing the frequency. It is When that kind of atypical chordae is placed in a posi- briefly transmitted parasternaly and toward heart apex. tion with normal blood flow, it produces a murmur sim- Pulmonary components of 2nd heart sound are normal. ilar to harp, which has a high frequency and produces a It is frequently seen in adolescents and it is the most com- very typical musical murmur, around the lower left edge mon accidental murmur in this age. Based on duration, it of sternum (so-called Still’s murmur) (5). is included in the first part of systole, when the speed of There is no dependency between localisation of acces- systole ejection is at its maximum. Fast flow through an sory chordae and maximal point of earshot of that mur- exit tract of the right ventricle, which is relatively super- mur. ficial leads to trgonization/inconsistency of pulmonary cusps. Usually, the murmur is louder, when the patient 2. AIM is in a lying position, and after laying stress/overload, be- To point out the significance of auscultation of the cause of an increase in venous flow and stroke volume of heart in the differentiation of heart murmurs and show the right ventricle. It is possible that murmur develops clinical characteristics of accidental heart murmurs. due to compression of pulmonary artery with following increase of cardiac phase and cardiac ejection. 3. MATERIAL AND METHODS The systolic murmur of pulmonary flow in neonates Article presents review of literature which deals with (physiological murmur of pulmonary stenosis in ne- the issue of accidental heart murmurs in the pediatric onates) most commonly is lost on end of the second cardiology. month of life (present in premature babies and neonates). It is ejection type, 1st or 2nd degree by Levine, and heard 4. RESULTS on both sides on the bases of heart with propagation to Classic vibratory parasternal–precordial Stills exile and the back. Short, usually developed due to tur- murmur (described by Still in 1918) is a systolic ejec- bulence of blood on bifurcation of the pulmonary artery. tion murmur which constitutes over 50% of all accidental This is the weakest, by intensity, systolic murmur and murmurs, best heard in area between ictus and lower left best audible on the base of the heart, in exile, under arm- edge of sternum (maximal puncture is most common- pits and in the back, on both sides. ly between 3rd and 4th intercostal space, on the left), Venous hum (cervical venous hum, spindle mur- usual intensity is between 2nd and 3rd degree based on mur) represents continuous murmur which may appear Levine’s scale low-freqency, with duration in the first half like profound silent and soft humming, with maximal or first two thirds of systole, by the quality it can be musi- audibility in systole. It is auscultated with fast blood flow, cal, vibratory, buzzing, pinking, blubbering/sobbing (6). from the jugular vein into superior vena cavae, within the Sometimes the murmur may radiate towards exile. Most right edge of the manubrium of the sternum, although it frequently it is seen in children of preschool age, between can be auscultated on the left in second intercostal space the age of 3 to 7, it is increased with states of tachycardia, (9). overload states, and is more audible/perceptible in lying It is also heard on the right with the neck, and on the position. It correlates with presence of aberrant chordae front part of the thorax (above and below the clavicle). in depth of left ventricle (36%). It is the most common Maximal pointer is sometimes located just below right of all accidental murmurs. McKusic considers that the clavicle. These murmurs are usually seen in anemic pa- cause of these murmurs is trigonization/inconsistency tients, and are most prominent in sitting position and of pulmonary cusps in systole. Some studies show that loosing on intensity, and nearly stoping in lying position. parasternal-precordial murmurs may be third, or even They are completely absent during the compression of fourth degree, based on intensity, when is also possible jugular veins in the neck.
Recommended publications
  • A Case Report of Takotsubo Syndrome Complicated by Ischaemic Stroke: the Clinical Dilemma of Anticoagulation
    European Heart Journal - Case Reports CASE REPORT doi:10.1093/ehjcr/ytab051 Other A case report of takotsubo syndrome complicated by ischaemic stroke: the clinical dilemma of anticoagulation Giuseppe Iuliano 1, Rosa Napoletano2, Carmine Vecchione 1,3, and Downloaded from https://academic.oup.com/ehjcr/article/5/3/ytab051/6170700 by guest on 01 October 2021 Rodolfo Citro 1* 1Cardiothoracic and Vascular Department, Cardiology Unit, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Heart Tower—Room 807, Largo Citta` d’Ippocrate, 84131 Salerno, Italy;; 2Neurology Department, Stroke Unit, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Largo Citta` d’Ippocrate, 84131 Salerno, Italy; and 3Vascular Pathophysiology Unit, IRCCS Neuromed, Via Atinense, 18, 86077 Pozzilli, Isernia, Italy Received 2 September 2020; first decision 22 October 2020; accepted 28 January 2021 For the podcast associated with this article, please visit https://academic.oup.com/ehjcr/pages/podcast Background Takotsubo syndrome (TTS) is an acute and transient heart failure syndrome due to reversible myocardial dysfunc- tion characterized by a wide spectrum of possible clinical scenarios. About one-fifth of TTS patients experience ad- verse in-hospital events. Thromboembolic complications, especially stroke, have been reported, albeit in a minority of patients. ................................................................................................................................................................................................... Case summary A 69-year-old woman presented to our emergency department for dyspnoea after a family quarrel. Electrocardiogram revealed ST-segment elevation in anterolateral leads and laboratory exams showed a slight ele- vation of high-sensitivity cardiac troponin. The patient was treated according to current guidelines on ST-elevation myocardial infarction and referred to the cath lab. Urgent coronary angiography revealed normal coronary arteries.
    [Show full text]
  • Heart Sound Classification for Murmur Abnormality Detection Using an Ensemble Approach Based on Traditional Classifiers and Feature Sets
    Anatolian Journal of Computer Sciences Volume:5 No:1 2020 © Anatolian Science pp:1-13 ISSN:2548-1304 Heart Sound Classification for Murmur Abnormality Detection Using an Ensemble Approach Based on Traditional Classifiers and Feature Sets Ali Fatih Gündüz1*, Ali Karcı2 *1Akçadağ Voc. Highschool, Malatya Turgut Ozal Uni., Malatya, Turkey ([email protected]) 2Department of Computer Eng., Inonu University, Malatya, Turkey, ([email protected]) Received Date: Jan. 7, 2020. Acceptance Date: Mar. 21, 2020. Published Date : Jun. 1, 2020. Abstract— Phonocardiography (PCG) is a method based on examination of mechanical sounds coming from heart during its regular contraction/relaxation activities such as opening and closing of the valves and blood turbulence towards vessels and heart chambers. Today there are high technology tools to record those sounds in electronic environment and enable us to analyze them in detail. The constraints such as human’s limited audible range, environment noise and inexperience of physicians can be overcome by the use of those tools and development of state-of-art signal processing and machine learning methods. In this study we examined heart sounds and classified them as normal or abnormal focusing on the efficiency of ensemble classifiers. Features of heart sounds are extracted by using Discrete Wavelet Transform (DWT), Mel-Frequency Cepstral Coefficients (MFCC) and time-domain morphological characteristics of the signals. As a novel contribution, Karcı entropy is derived from DWT of PCG signals and used for the first time as feature in heart sound classification. K-Nearest Neighbor (kNN), Support Vector Machine (SVM), Multilayer Perceptron (MLP) classifiers and their ensembles are used as classifiers.
    [Show full text]
  • MIT Automated Auscultation System By
    MIT Automated Auscultation System by Zeeshan Hassan Syed S.B., Computer Science and Engineering Massachusetts Institute of Technology (2003) Submitted to the Department of Electrical Engineering and Computer Science in partial fulfillment of the requirements for the degree of Master of Engineering in Electrical Engineering and Computer Science at the MASSACHUSETTS INSTITUTE OF TECHNOLOGY May 2003 @Zeeshan H. Syed, MMIII. All rights reserved. The author hereby grants to MIT permission to reproduce and publicly distribute paper and electronic copies of this thesis document in whole or in part. MASSACHUSETTS INSTiTUTE OF TECHNOLOGY JUL 2 0 2004 LIBRARIES A uthor . ...................... o lectrical Engineering and Computer Science May 9, 2003 Certified by... .. ....... John V. Guttag Professor, ComDuter Science and Engineering Thesis Supervisor Accepted by........... Arthur C. Smith Chairman, Department Uommittee on Graduate Theses BARKER 2 MIT Automated Auscultation System by Zeeshan Hassan Syed S.B., Computer Science and Engineering Massachusetts Institute of Technology (2003) Submitted to the Department of Electrical Engineering and Computer Science on May 9, 2003, in partial fulfillment of the requirements for the degree of Master of Engineering in Electrical Engineering and Computer Science Abstract At every annual exam, the primary care physician uses a stethoscope to listen for cardiac abnormalities. This approach is non-invasive, inexpensive, and fast. It is also highly unreliable. Over 80% of the people referred to cardiologists as suffering from the most commonly diagnosed condition, mitral valve prolapse (MVP), do not have this condition. Working in conjunction with cardiologists at MGH, we developed a robust, low cost, easy to use tool that can be employed to diagnose MVP in the office of pri- mary care physicians.
    [Show full text]
  • Ministry of Health of Ukraine Kharkiv National Medical University
    Ministry of Health of Ukraine Kharkiv National Medical University AUSCULTATION OF THE HEART. NORMAL HEART SOUNDS, REDUPLICATION OF THE SOUNDS, ADDITIONAL SOUNDS (TRIPLE RHYTHM, GALLOP RHYTHM), ORGANIC AND FUNCTIONAL HEART MURMURS Methodical instructions for students Рекомендовано Ученым советом ХНМУ Протокол №__от_______2017 г. Kharkiv KhNMU 2017 Auscultation of the heart. normal heart sounds, reduplication of the sounds, additional sounds (triple rhythm, gallop rhythm), organic and functional heart murmurs / Authors: Т.V. Ashcheulova, O.M. Kovalyova, O.V. Honchar. – Kharkiv: KhNMU, 2017. – 20 с. Authors: Т.V. Ashcheulova O.M. Kovalyova O.V. Honchar AUSCULTATION OF THE HEART To understand the underlying mechanisms contributing to the cardiac tones formation, it is necessary to remember the sequence of myocardial and valvular action during the cardiac cycle. During ventricular systole: 1. Asynchronous contraction, when separate areas of myocardial wall start to contract and intraventricular pressure rises. 2. Isometric contraction, when the main part of the ventricular myocardium contracts, atrioventricular valves close, and intraventricular pressure significantly increases. 3. The ejection phase, when the intraventricular pressure reaches the pressure in the main vessels, and the semilunar valves open. During diastole (ventricular relaxation): 1. Closure of semilunar valves. 2. Isometric relaxation – initial relaxation of ventricular myocardium, with atrioventricular and semilunar valves closed, until the pressure in the ventricles becomes lower than in the atria. 3. Phases of fast and slow ventricular filling - atrioventricular valves open and blood flows from the atria to the ventricles. 4. Atrial systole, after which cardiac cycle repeats again. The noise produced By a working heart is called heart sounds. In auscultation two sounds can be well heard in healthy subjects: the first sound (S1), which is produced during systole, and the second sound (S2), which occurs during diastole.
    [Show full text]
  • 6-Heart Sounds.Pdf
    CARDIOVASCULAR SYSTEM HEART SOUNDS Dr Syed Shahid Habib MBBS DSDM PGDCR FCPS Professor & Consultant Clinical Neurophysiology Dept. of Physiology College of Medicine & KKUH King Saud University PROF. HABIB 2018 OBJECTIVES At the end of the lecture you should be able to ….. 1. Enumerate the different heart sounds 2. Describe the cause and characteristic features of first and second heart sound 3. Correlate the heart sounds with different phases of cardiac cycle 4. Define murmurs and their clinical importance PROF. HABIB 2018 HEART SOUNDS D U P L U B B L U B B Heart sounds PROF. HABIB 2018 BEST HEARD AT 4 AREAS OF AUSCULTATION AREAS: ■ Pulmonary area: • 2nd Lt intercostal space ■ Aortic area: • 2nd Rt costal cartilage ■ Mitral area: • 5nd Lt intercostal space crossing mid- clavicular line, or • 9cm (2.5-3 in) from sternum ■ Tricuspid area: • lower part of sternum towards Rt side PROF. HABIB 2018 PROF. HABIB 2018 The Events of the Cardiac Cycle HEART SOUNDS • There are four heart sounds SI, S2, S3 & S4. • Two heart sound are audible with stethoscope S1 & S2 (Lub - Dub). • S3 & S4 are not audible with stethoscope Under normal conditions because they are low frequency sounds. • Ventricular Systole is between First and second Heart sound. • Ventricular diastole is between Second and First heart sounds. PROF. HABIB 2018 FIRST HEART SOUND (S1) • It is produced due to the closure of Atrioventricular valves (Mitral & Tricuspid) • It occurs at the beginning of the systole and sounds like LUB (beginning of the ‘isometric contraction’ phase) • Frequency: 25-45 Hz • Time: 0.15 sec • Its is heavier when compared to the 2nd heart sound.
    [Show full text]
  • Hypertension Core Curriculum. Final.Indd
    MICHIGAN HYPERTENSION CORE CURRICULUM Education modules for training and updating physicians and other health professionals in hypertension detection, treatment and control Developed by the Hypertension Expert Group A Partnership of the National Kidney Foundation of Michigan and the Michigan Department of Community Health 2010 Michigan Hypertension Core Curriculum 2010 Developed by the Hypertension Expert Group A Partnership of the National Kidney Foundation of Michigan and the Michigan Department of Community Health 2 Hypertension Core Curriculum NKFM & MDCH 3 Acknowledgements Hypertension Expert Workgroup Committee April 2010 Ziad Arabi, MD, Senior Staff Physician, Internal Medicine/Hospitalist Medicine, Henry Ford Hospital, Certified Physician Specialist in Clinical Hypertension* Dear Colleague: Aaref Badshah, MD, Chief Medical Resident, Department of Internal Medicine Saint Joseph Mercy-Oakland Hospital * In 2005, the Michigan Department of Community Health (MDCH) and the National Kidney Foundation of Michigan (NKFM) convened a group of hypertension experts to identify strategies that will improve Jason I Biederman DO, FACOI FASN, Hypertension Nephrology Associates, PC* blood pressure control in Michigan. Participants included physicians from across Michigan specializing Joseph Blount, MD, MPH, FACP, Medical Director, OmniCare Health Plan, Detroit, MI in clinical hypertension, leaders in academic research of hypertension and related disorders, and Mark Britton, MD, PhD, Center of Urban and African-American Health Executive Committee, Wayne representatives of key health care organizations that are addressing this condition that afflicts over 70 State University School of medicine, Wayne State University* million U.S. adults. The Hypertension Expert Group has focused on approaches to reduce the burden of kidney and cardiovascular diseases through more effective blood pressure treatment strategies.
    [Show full text]
  • Test Questions – INTERNAL PROPEDEUTIC – 3Rd Year GM, Winter Semester 1
    Test questions – INTERNAL PROPEDEUTIC – 3rd Year GM, winter semester 1. Pain is: 49. A hard, irregular prostatic gland suggests: 2. Dyspnea is: 50. Inhealthy individual the abdominal wall is: 3. Sign is: 51. Undulation (fluid wave) test is used in the 4. Subjective feelings of the patient are: examination of: 5 .Abdominal bruit: 52. Rectal examination should be routine in the 6. An enlarged left kidney from the enlarged spleen following circumstances: may be differentiated by palpation: 53. Elevated niveau of abdomen above chest can be 7. Abdominal angina: present in: 8. Blumberg sign is positive in inflammation of 54. Jaundice, septic fever and right upper quadrant pain 9. Caput medusae is common in is a common characteristic of 10. Cullen sign: 55. Ankle-brachial index informs about: 11. Defence musculaire is 56. Diabetic foot: 12. Defense musculaire is 57. Homans’s sign: 13. Grey-Turner sign: 58. Cold and pale lower limb is typical for: 14. Deep palpation is usually not limited in: 59. Claudication pain in peripheral artery disease: 15. The upper border of the liver in midclavicular line 60. Lowenberg ́s sign: may be assessed: 61. Which arteries are not usually palpated on lower 16. Incarcerated hernia is: limbs: 17. The scar parallel to right costal margin is typical 62. Oedema of lower extremities caused by renal for diseases: 18. The respiratory movements from xiphoid to both 63. Phlegmasia coerulea dolens is sign of: inguinal regions are completely absent in: 64. Postphlebitic syndrome: 19. Which organs are projecting to right upper 65. Claudication pain of lower extremities: abdominal quadrant: 66.
    [Show full text]
  • ACCF/AHA 2011 Expert Consensus Document on Hypertension in The
    Journal of the American College of Cardiology Vol. 57, No. 20, 2011 © 2011 by the American College of Cardiology Foundation and the American Heart Association, Inc. ISSN 0735-1097/$36.00 Published by Elsevier Inc. doi:10.1016/j.jacc.2011.01.008 EXPERT CONSENSUS DOCUMENT ACCF/AHA 2011 Expert Consensus Document on Hypertension in the Elderly A Report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents Developed in Collaboration With the American Academy of Neurology, American Geriatrics Society, American Society for Preventive Cardiology, American Society of Hypertension, American Society of Nephrology, Association of Black Cardiologists, and European Society of Hypertension Writing Wilbert S. Aronow, MD, FACC, Co-Chair* Eduardo Ortiz, MD, MPH† Committee Jerome L. Fleg, MD, FACC, Co-Chair† Efrain Reisin, MD, FASN** Members Carl J. Pepine, MD, MACC, Co-Chair* Michael W. Rich, MD, FACC†† Douglas D. Schocken, MD, FACC, FAHA‡‡ Nancy T. Artinian, PHD, RN, FAHA‡ Michael A. Weber, MD, FACC§§ ʈʈ George Bakris, MD, FASN Deborah J. Wesley, RN, BSN Alan S. Brown, MD, FACC, FAHA‡ *American College of Cardiology Foundation Representative; †Na- Keith C. Ferdinand, MD, FACC§ tional Heart, Lung, and Blood Institute; ‡American Heart Association ʈ Representative; §Association of Black Cardiologists Representative; Mary Ann Forciea, MD, FACP ʈAmerican College of Physicians Representative; ¶American Academy William H. Frishman, MD, FACC* of Neurology Representative; #European Society of Hypertension Representative; **American Society of Nephrology Representative; Cheryl Jaigobin, MD¶ ††American Geriatrics Society Representative; ‡‡American Society for Preventive Cardiology Representative; §§American Society of Hyper- John B. Kostis, MD, FACC tension Representative; ʈʈACCF Task Force on Clinical Expert Con- Giuseppi Mancia, MD# sensus Documents Representative.
    [Show full text]
  • EPIC Change to the Management of Mitral Valve Disease
    FOCUS > COMPANION ANIMAL EPIC change to the management of mitral valve disease An EPIC change to the management of canine mitral valve disease is discussed by Jenny Wilshaw BVet- Med MRCVS, PhD Student, Royal Veterinary College, London, UK Stage Definition A Individuals in this stage have no identifiable structural valve lesions (At risk) but, based on signalment, are at risk of developing MVD B This is the asymptomatic Stage B1: No evidence of (Asymp- (preclinical) stage of MVD. Stage cardiomegaly tomatic) B is used to identify patients that have valvular disease but Stage B2: Echocardiographic do not have congestive heart and/or radiographic evidence of failure (CHF). The stage is left-sided cardiac enlargement subcategorised numerically C Patients have experienced clinical signs of CHF and require continuous medical therapy with a potent diuretic D Patients have clinical signs of CHF that are refractory to standard therapies Table 1: The American College of Veterinary Internal Medicine staging scheme for degenerative mitral valve disease. Adapted from: Atkins C, Bonagura J, Ettinger S et al. Guidelines for the diagnosis and treatment of canine chronic valvular heart disease. J Vet Intern Med 2009; 23: 1142-1150. ASYMPTOMATIC MVD AND THE EPIC STUDY The EPIC study was a large, prospective, blinded, randomised placebo-controlled trial that evaluated the benefit of chronic oral administration of pimobendan to dogs with stage B2 disease (see Table 1).1,2 The results of EPIC showed a significant benefit to treating these dogs with pimobendan (Vetmedin), as the risk of developing CHF or cardiac-related death was reduced by 36% for dogs in the treatment group.
    [Show full text]
  • Department of Pediatric Neurology and Pediatrics Medical University of Warsaw } from 3-5 to 12 in 1000 Live Births
    Department of Pediatric Neurology and Pediatrics Medical University of Warsaw } From 3-5 to 12 in 1000 live births } Average 10 in 1000 live births } In most cases cardiac surgery is required, usually in the first year of life } multifactorial, usually unknown } most of defects are sporadic } Higher risk of disease in children with relevant family history of cardiovascular abnormalities } Some defects are associated with chromosomal anomalies (Down syndrome) } Environmental factors acting in utero : ◦ Infections e.g.: rubella ◦ Diabetes mellitus ◦ Lupus erythematosus ◦ Alcoholism ◦ Epilepsy ◦ Some medications (e.g. hydantoin) } Case history } Physical examination } ECG } Thoracic X-ray } Echocardiography } Isotope angiography } Cardiac catheterization and angiocardiography } Examination by: ◦ Watching ◦ Palpating ◦ Percussion ◦ Ascultation } The most common abnormalities: ◦ Cyanosis ◦ Abnormal cardiac tones ◦ Heart murmurs ◦ Heart failure } 1- very silent } 2- soft, audible but silent } 3- audible, but without the thoracic tremor } 4- audible, with thoracic tremor } 5- loud, audible with stetoscope } 6- very loud, audible without the stetoscope } Heart murmurs } Abnormal respiration (tachypnea) } Cyanosis } Cardiac arrhythmias } Cardiomegaly on X-ray } Hepatomegaly, peripheral and lung oedema } Abnormal peripheral pulse } Occurs when concentration of deoxygenated haemoglobin is over 5 g% } Evaluation of oxygenation of haemoglobin based on skin colour is unreliable } More reliable assessment based on intensity of discoloration of tongue
    [Show full text]
  • ACCF/AHA 2011 Expert Consensus Document on Hypertension in The
    ACCF/AHA 2011 Expert Consensus Document on Hypertension in the Elderly American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents, American Academy of Neurology, American Geriatrics Society, American Society for Preventive Cardiology, American Society of Hypertension, American Society of Nephrology, Association ofBlack Cardiologists, European Society of Hypertension, Wilbert S. Aronow, Jerome L. Fleg, Carl J. Pepine, Nancy T. Artinian, George Bakris, Alan S. Brown, Keith C. Ferdinand, Mary Ann Forciea, William H. Frishman, Cheryl Jaigobin, John B. Kostis, Giuseppi Mancia, Suzanne Oparil, Eduardo Ortiz, Efrain Reisin, Michael W. Rich, Douglas D. Schocken, Michael A. Weber, and Deborah J. Wesley J. Am. Coll. Cardiol. published online Apr 25, 2011; doi:10.1016/j.jacc.2011.01.008 This information is current as of April 25, 2011 The online version of this article, along with updated information and services, is located on the World Wide Web at: http://content.onlinejacc.org/cgi/content/full/j.jacc.2011.01.008v1 Downloaded from content.onlinejacc.org by on April 25, 2011 Journal of the American College of Cardiology Vol. 57, No. 20, 2011 © 2011 by the American College of Cardiology Foundation and the American Heart Association, Inc. ISSN 0735-1097/$36.00 Published by Elsevier Inc. doi:10.1016/j.jacc.2011.01.008 EXPERT CONSENSUS DOCUMENT ACCF/AHA 2011 Expert Consensus Document on Hypertension in the Elderly A Report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents Developed in Collaboration With the American Academy of Neurology, American Geriatrics Society, American Society for Preventive Cardiology, American Society of Hypertension, American Society of Nephrology, Association of Black Cardiologists, and European Society of Hypertension Writing Wilbert S.
    [Show full text]
  • Cardiac Auscultation: Normal and Abnormal
    This is a repository copy of Cardiac auscultation: normal and abnormal. White Rose Research Online URL for this paper: http://eprints.whiterose.ac.uk/145443/ Version: Accepted Version Article: Warriner, D., Michaels, J. and Morris, P.D. orcid.org/0000-0002-3965-121X (2019) Cardiac auscultation: normal and abnormal. British Journal of Hospital Medicine, 80 (2). C28-C31. ISSN 1750-8460 10.12968/hmed.2019.80.2.C28 This document is the Accepted Manuscript version of a Published Work that appeared in final form in British Journal of Hospital Medicine, copyright © MA Healthcare, after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.12968/hmed.2019.80.2.C28 Reuse Items deposited in White Rose Research Online are protected by copyright, with all rights reserved unless indicated otherwise. They may be downloaded and/or printed for private study, or other acts as permitted by national copyright laws. The publisher or other rights holders may allow further reproduction and re-use of the full text version. This is indicated by the licence information on the White Rose Research Online record for the item. Takedown If you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing [email protected] including the URL of the record and the reason for the withdrawal request. [email protected] https://eprints.whiterose.ac.uk/ Cardiac Auscultation: normal and abnormal Dr David Warriner1, Dr Joshua Michaels2, Dr Paul D Morris3,4 Dr Warriner is a senior cardiology registrar (St7), Dr Michaels is a Foundation Year 2 (FY2) doctor and Dr Morris is NIHR Clinical Lecturer and BCIS Fellow.
    [Show full text]