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United States Patent (19) 11 Patent Number: 5,834,409 Ramachandran Et Al

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United States Patent (19) 11 Patent Number: 5,834,409 Ramachandran Et Al USOO5834.409A United States Patent (19) 11 Patent Number: 5,834,409 Ramachandran et al. (45) Date of Patent: *Nov. 10, 1998 54 SCALP CARE PRODUCTS CONTAINING 4,867,971 9/1989 Ryan et al. ............................... 424/81 ANTI ITCHING/ANTI IRRITANT AGENTS 4.885,107 12/1989 Wetzel ... 252/106 4,895,727 1/1990 Allen ... ... 424/642 (75) Inventors: Pallassana Narayanier 4,921,170 5/1990 Grollier ................................... 239/304 4,925,659 5/1990 Grollier et al. ........................... 424/78 Ramachandran, Robbinsville; 4997,641 3/1991 Hartnett et al. ... 424/70 Clarence Ralph Robbins, Martinsville; 4,999,195 3/1991 Hayes.............. ... 424/114 Amrit Manilal Patel, Dayton, all of 5,002,761 3/1991 Mueller et al. ... 424/70 N.J. 5,051,250 9/1991 Patel et al. ... ... 424/70 5,091,171 2/1992 Yu et al. ......... 424/642 73) Assignee: Colgate-Palmolive Company, New 5,100,658 3/1992 Bolich, Jr. et al. ... 424/70 York, N.Y. 5,104,646 4/1992 Bolich, Jr. et al. ..... ... 424/70 5,106,609 4/1992 Bolich, Jr. et al. ... 424/70 Notice: This patent issued on a continued pros 5,106,613 4/1992 Hartnett et al. ........................... 424/71 ecution application filed under 37 CFR 5,151,209 9/1992 McCall et al... 252/174.15 1.53(d), and is subject to the twenty year 5,213,716 5/1993 Patel et al. .............................. 252/547 patent term provisions of 35 U.S.C. 5,346,642 9/1994 Patel et al. 252/174.21 5,348,736 9/1994 Patel .......................................... 424/70 154(a)(2). 5,505,949 4/1996 Benitez ................................... 424/401 5,523,080 6/1996 Gough et al. ... 424/70.12 Appl. No.: 598,411 5,525,332 6/1996 Gough et al. ... ... 424/70.12 5,582,832 12/1996 Pillai et al. ............................. 424/401 Filed: Feb. 8, 1996 FOREIGN PATENT DOCUMENTS Related U.S. Application Data 0034846 9/1981 European Pat. Off. ......... A61K 7/08 0136914 4/1985 European Pat. Off. ......... A61K 7/08 63 Continuation of Ser. No. 411.883, Mar. 31, 1995, aban 0196824 10/1986 European Pat. Off. ......... A61K 7/06 doned. 0202621 11/1986 European Pat. Off. ......... A61K 7/06 51 Int. Cl." .............................. C11D 1/02; C11D 1/94; 0285389 10/1988 European Pat. Off. ......... A61K 7/08 C11D 3/28 0312234 4/1989 European Pat. Off. ......... A61K 7/06 U.S. Cl. .......................... 510/125; 510/127; 510/131; 0536820 4/1993 European Pat. Off. ........ C11D 1/825 52) 510/133; 510/137; 510/138; 510/158; 510/159; 1502144 2/1978 Germany ............... ... A61K 7/06 510/500; 424/59; 424/78.03; 424/78.07; 94O9755 5/1994 WIPO .............................. A61K 7/48 514/846; 514/847; 514/859; 514/385; 514/396 Primary Examiner Douglas J. McGinty 58 Field of Search ..................................... 510/131, 133, Assistant Examiner-Gregory R. Delcotto 510/137, 138, 158, 159, 500, 125, 127; Attorney, Agent, or Firm-Rosemary M. Miano; Richard N. 424/59, 78.03, 78.07; 514/846, 847, 859, Miller 385, 396 57 ABSTRACT 56) References Cited Mild aqueous detergent, e.g., Shampoo, compositions are U.S. PATENT DOCUMENTS disclosed based on a mixture comprising anionic Surfactant and amphoteric Surfactant, Such as betaines, present in the 3,506,720 4/1970 Model et al. ........................... 260/613 composition at a level of from about 0.75 to 1.25 parts by 3,560,614 2/1971 Embring ........ ... 424/234 weight per part by weight of anionic Surfactant. The com 3,694,547 9/1972 Forsthoff et al. ......................... 424/94 positions also contain one or a mixture of therapeutic agents 4,089,945 5/1978 Brinkman et al. ... 424/164 4,111,844 9/1978 Polony et al. ... ... 252/106 Such as climbazole or a mixture of climbazole and one or 4,329,334 5/1982 Su et al. .................................... 424/70 more co-therapeutics Such as Salicylic acid. The combina 4,329,335 5/1982 Su et al. .................................... 424/70 tion of mild Surfactant System and therapeutic agent Serve to 4,329,336 5/1982 Su et al. .................................... 424/70 prevent or treat mild Skin disorderS Such as Scalp itch and 4,450,090 5/1984 Kinney .......... ... 252/106 Scalp irritation when applied to the Scalp as a shampoo. 4,472,421 9/1984 Buchel et al. ... 424/273 Shampoo compositions also preferably contain one or more 4,489,085 12/1984 Draber et al. ........................... 424/273 conditioning agents and Suitable Suspending agents. 4.595,526 6/1986 Lai .......................................... 252/545 4,731,201 3/1988 Robbins et al. .. ... 252/551 4,767,750 8/1988 Jacquet et al. ... ... 514/159 The invention also provides a method for treating dry skin 4,822,604 4/1989 Knoll et al. ............................... 424/70 comprising applying certain of the therapeutic agents to dry 4,835,148 5/1989 Barford et al. ... ... 514/179 skin to promote the natural Secretion of Sebum. 4,849,214 7/1989 Ruiseco ..................................... 424/74 4,854,333 8/1989 Inman et al. ............................ 132/209 6 Claims, No Drawings 5,834,409 1 2 SCALP CARE PRODUCTS CONTAINING one, (climbazole) acetylsalicylic acid, Salicylic acid, 2,4,4, ANTI ITCHING/ANTI IRRITANT AGENTS '-trichloro-2'-hydroxy diphenyl ether (triclosan); 1-acetyl-4- (4-((2-(2,4-dichlorophenyl)-2-(1H-imidazolyl-1-methyl)-1, This is a continuation of application Ser. No. 08/411,883 3-dioxolan-4-yl)methoxy) phenyl)-pipe razine filed Mar. 31, 1995, now abandoned. (Ke to conazole), 1-hydroxy-4-methyl-6-(2,4,4- trimethylpentyl)-2-pyridone monoethonolamine Salt BACKGROUND OF THE INVENTION (picrotone olamine); Selenium Sulfide; Zinc pyrithione; coal tar, Sulfur, 2-(4-isobutylphenyl) propionic acid (ibuprofen); 1. Field of the Invention and mixtures thereof. The invention relates to skin care compositions which The invention also provides for a method of treating Scalp exhibit a therapeutic effect in the treatment of skin disorders disorderS Such as Scalp irritation and/or itching comprising Such as itching, irritation and skin dryneSS. applying to the hair and Scalp compositions of the invention 2. Description of Related Art as a shampoo and rinsing the Shampoo from the hair after There are a number of Shampoo products on the market Shampooing. today which are Specifically formulated as anti-dandruff 15 Therapeutic testing of individuals living in tropical cli Shampoos. These products generally contain one or a mix mates has demonstrated that the detergent compositions of ture of Surfactants, with the primary Surfactant being an the invention, particularly in the form of Shampoos, Serve anionic Surfactant Such as an alkyl or aryl Sulfate or Sul both to prevent the onset of minor Scalp disorders in indi fonate. One hypothesis is that dandruff problems are viduals previously free of disorder and to provide therapeu believed to be linked to the presence of a yeast-like fungus tic healing of Such disorders in individuals presented with on the skin and an acceleration of the normal process of skin Such disorders. production. Conventional anti-dandruff Shampoos generally contain effective amounts of an active agent which inhibits DETAILED DESCRIPTION OF THE fungal growth and/or slows cell growth on the Scalp. INVENTION 25 Examples of these agents include Zinc pyrithione, Selenium Anionic Surfactants normally present in mild detergent Sulfide, Salicylic acid, coal tar, Sulfur, ketoconozole and compositions, especially shampoo formulations are used not climbazole. Examples of typical anti-dandruff Shampoo for only for detersive or cleansing performance, but because mulations are disclosed in U.S. Pat. Nos. 4,089,945; 4,329, they impart a high degree of foaming characteristics to the 334; 4,329,335; 4,329,336 and 4,835,148. detergent composition or shampoo, which enhances con However, experience has shown that excessive dandruff is Sumer appeal. However, the anionics are generally much largely a problem associated with cold, dry climates and it more irritating to the skin than are the amphoteric or generally does not occur until after puberty. In more humid, non-ionic Surfactants. On the other hand, these latter Sur tropical regions dandruff is a much less common disorder. factant types are considerably less foaming than the anionics However, inhabitants of these regions are generally more and are thus leSS appealing when used as a major or Sole Susceptible to mild forms of Scalp dermatitis with Such 35 Surfactant component in a detergent composition or a sham Symptoms as excessive Scalp itching, Scalp irritation, inflammation, Scalp dryneSS and Scalp redness. These Symp pOO. toms can also occur during the warm Summer months in The present invention is grounded on the discovery that non-tropical regions. Although many of these Symptoms use of a specific combination of anionic and amphoteric ought to be relieved by the use of the anti-fungal agents 40 Surfactants provides a mild Surfactant base for a therapeutic present in Some anti-dandruff Shampoos, e.g., climbazole, aqueous, body cleansing composition, particularly in the Zinc pyrithione or Selenium Sulfide, experience has demon form of a shampoo, Such that the Surfactant System does not Strated that these Symptoms are not relieved and, in fact, are tend to counteract or negate the therapeutic benefits afforded even worsened by regular use of many commercial anti by the therapeutic agents present in the body cleansing dandruff hair Shampoos. 45 composition or Shampoo. Suitable anionic Surfactants which may be used include Accordingly it is a primary object of this invention to the water-Soluble alkali metal or ammonium Salts having provide a mild, aqueous, Skin care detergent composition, alkyl radicals containing from about 8 to about 22 carbon e.g., a Scalp care shampoo or a shower cleansing atoms, the term alkyl being Sued to include the alkyl portion composition, which exhibits a therapeutic effect on Skin 50 of higher acyl radicals.
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