DOCSLIB.ORG

Taking the Pulse of Biotech

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Taking the Pulse of Biotech A Conversation with Nancy Chang OnTheRecord Taking the Pulse of Biotech Biotechnology is risky business. For every start-up that succeeds, between 15 and 20 fail. for HIV, just to prepare the materials alone cost $50,000 per patient, not counting our Houston Branch board member Nancy Chang beat the odds with Tanox Inc., a 20-year-old costs or our time. biotech company that has agreed to be acquired by industry behemoth Genentech Inc. When Tanox first started, I put every- thing I had into the company. We didn’t pay ourselves salaries; the company’s first tele- Q: With such a high failure rate, are biotechs phone system was built on borrowed mon- at risk of extinction? ey. But we did what we had to do to make progress, to grow the company, and these A: Just the opposite. Pharmaceutical compa- were gutsy, risky moves. nies are realizing that it’s so expensive to discover new drugs that they’re relying more Q: How has globalization changed the and more on biotechs for the discovery, de- pharmaceutical industry? velopment and concept phases. Look at it as Big Pharma relying on the little guy. This A: Every biotech company that starts out to- way, they don’t have to pay for the failures. day is global by necessity. You have to learn Eventually, they partner with the smaller how to do business all over the world, to do biotechs that do pass muster. research and development work outside the U.S., to have partnerships with international Q: You came to the U.S. from Taiwan at age companies, to deal with different regulatory 23, earned a Ph.D. from Harvard and started a agencies in other countries. You have to ap- biotech company. How did that come about? preciate that the world is small, but you have to look at it as one big marketplace. A: I was a professor at the Baylor College Part of it is the Internet. When you do of Medicine. At the time, we discovered an research, everything you publish is on the antibody that neutralized the HIV virus. The Internet. The pace of turning knowledge department chairman was so excited about and new technology into a commodity has the discovery that he suggested we commer- become faster, in a way, because so much cialize it. information is at your fingertips—all you My husband at the time was just begin- includes a viral-entry inhibitor antibody to need is the desire to know. ning to work on the idea of developing an treat HIV/AIDS. In 2006, Tanox completed a The industry still has a good profit mar- anti-IgE as an allergy treatment. IgE is the phase 2 trial for this drug showing that it is gin, so people naturally want to be in the causative agent in allergy diseases. During safe and effective in reducing the HIV viral field. In China, India and other countries, that time, we also needed additional space load in AIDS patients. there are both the profit motive and the for our laboratories. All of these things need for better medicine at cheaper prices, seemed to happen at the same time, and we Q: What are the biggest challenges facing a and they are investing in this industry. thought, “Why don’t we start a company?” biotech start-up? We formed Tanox in 1986 to focus on Q: Will China emerge as a leader in the both HIV and allergies. We took the allergy A: As inventors, we take all of the risk in the pharmaceutical industry? drug from concept to market. Back then, beginning. In the end, we partner with big- the idea of creating a molecule that could ger companies to get access to the resources A: China may have the ambition, but I don’t take away the causative agent in allergies we need to make a drug a reality. believe its focus at this time is to develop the was revolutionary and counter to the central Take Xolair. It took us 17 years of steady next generation of drugs. North America will dogma. work to develop. We took risks and staked continue to be the leader for new medicine Twenty years later, after partnering with our careers and Tanox’s future on this one in the next 10 to 15 years. Novartis and Genentech, we had a drug drug, taking it from beginning to end. We What I believe the Chinese would like named Xolair. It was the first antibody ever are fortunate that the drug worked. Some- to focus on is providing better health care approved by the Food and Drug Administra- times the drugs may not work, and people’s overall to its people. In doing so, China tion to treat moderate to severe asthma. In careers can be over. will expand the market for the current gen- 2006, Xolair sales were close to $450 mil- To initiate a human study requires a ma- eration of drugs. Even if you’re just talking lion worldwide. In addition to Xolair, Tanox jor commitment for a small company. For in- about 1 percent of 1.3 billion people, that’s a now has a solid pipeline of new drugs that stance, for our very first human clinical study major market in the making. What is of real SouthwestEconomy 8 FEDERAL RESERVE BANK OF DALLAS • MARCH/APRIL 2007 “Every biotech company that starts out today is global by necessity.” concern is what will happen to the Chinese continue to come people as they become more affluent and to the U.S. seeking prosperous. The incidence of chronic con- better opportunities; ditions such as cardiovascular disease and they are the force be- diabetes will increase, and that will require a hind creativity in the lot of resources to manage. U.S. But this, too, is changing. What if, in Q: So the opening up of China and other the future, people no countries has impacted how the pharmaceutical longer want to come industry has evolved? to study in the U.S. or no longer have to? A: It definitely has. Before, a majority of the What if the knowl- discovery process was done in the United edge base stays home? States. Now, a lot of the processes are being At some point, we will have to face the tre- handle drug distribution or provide proper offshored to India and China. Many compa- mendous risks of brain drain. medical and nursing services to patients suf- nies are now doing the early phases of drug fering from this terrible disease. screening, proof-of-concept studies and even Q: How can the U.S. maintain its edge in the early phases of clinical development in medical research? Q: Clearly, the challenge remains for your emerging markets. industry to continue fighting against the Governments outside the U.S. allow you A: There is a price to pay for being the in- disease. more leeway for drug testing and research. novators, but it is also something we have to Countries like the United Kingdom, Singa- protect. We cannot look at everything as an A: HIV won’t be eradicated in our lifetime pore, China and South Korea are now lead- economic calculation. We have to preserve because of the way the virus stays in the ing the way with stem-cell research, aiming creativity and help people understand the infected cells. It’s incorporated into the host to build their reputations, competence and benefit of cross-fertilization across different DNA and hides there until the patient’s im- competitive advantages in this promising disciplines. Often, new ideas come from a mune system weakens. Patient survival de- new field while hurdles to U.S. research re- fresh look at old problems. pends on the ability to stay ahead of the main. We need an education system that en- curve. Adding more challenge to this situ- Anywhere there are major bottlenecks courages students to go into science and ation is that the virus keeps changing and in the U.S., the industry looks to other coun- technology, to do more than manage pro- can evade all therapeutic intervention. In the tries to get things done. If advances are made cesses, to do more than be a part of a service U.S., maybe 25 to 30 percent of the virus is overseas, these other countries may gain the industry. From grade schools to universities, resistant to all prevailing drugs. upper hand. creativity must be fostered in order for sci- HIV/AIDS is a disease in which patient ence to succeed in producing the next gen- advocacy has exerted strong influence on Q: What does the future hold for your industry eration of medicines. drug development and usage. Patients who in this country? have AIDS often live with the virus for years. Q: Where could globalization accomplish more? Many are intelligent and knowledgeable A: The good thing is that the U.S. is still the about their disease and the biology of the one place where people value creativity. A: Until just recently, globalization has not HIV infection. They know the drugs’ effica- There are savvy investors and hard-driving impacted the fighting of AIDS. It is clearly cies as well as their toxicities and want to entrepreneurs in the U.S. who are willing to a matter of the haves and the have-nots. see preventive vaccines and more effective invest their money, time and expertise on Today, you can carry the virus and expect antiviral therapies developed. So they have innovative ideas in new drug development.
Load more

Recommended publications
  • Fully Human Domain Antibody Therapeutics: the Best of Both Worlds
    Drug Discovery Fully Human Domain Antibody Therapeutics: The Best of Both Worlds By combining the therapeutic benefits of small molecule drugs with those of fully human antibodies, Domain Antibodies are expected to have strong therapeutic and commercial potential. By Robert Connelly at Domantis Robert Connelly is Chief Executive Officer of Domantis. He has over 22 years’ commercial experience of the life science sector, including that gained in the fields of diagnostics, drug discovery technologies and antibody therapeutics. Prior to joining Domantis, he was CEO of Veritas Pharmaceuticals (Los Angeles, USA), an in vivo imaging start-up company. He spent over five years with IGEN International, latterly as Senior Vice President and General Manager, Life Sciences, where he took part in the company’s IPO and financing rounds, raising $130 million. The first 11 years of his career were spent at Abbott Laboratories in sales, marketing and management positions. Domain Antibodies (dAbs) are the smallest functional variable regions of either the heavy (VH) or light (VL) binding units of antibodies. At Domantis, we are chains of human antibodies. Domantis scientists applying our proprietary know-how in dAbs to deliver have used the variable domains sequences of human human therapies that address large, unmet medical antibodies to create a series of large and highly needs in areas such as inflammation, cancer and functional libraries of fully human dAbs, with each autoimmune diseases. Three and a half years after library comprising at least 1010 different dAbs. The opening our laboratories, we have a dozen proprietary dAbs selected from these libraries are both specific therapeutic programmes underway, and an additional for their biological target and are well folded and eight therapeutic programmes with partners.
    [Show full text]
  • Power List 2018
    APRIL 2018 # 40 Editorial Upfront In My View Sitting Down With Stop and look at how far Preparing for the EU’s new What can algae teach us Sophie Kornowski-Bonnet, the industry has come data protection regulation about medicine design? Roche Partnering 09 10 – 11 20 – 21 50 – 51 100 Power List 2018 www.themedicinemaker.com Continuous Growth Fibra-Cel® disks—3-D growth matrix for perfusion and continuous processes Suspend your disbelief: > Less susceptible to shear forces, The three-dimensional Fibra-Cel matrix clogging, and fouling entraps anchorage dependent and > Ideal for secreted product and vaccine suspension cells—for optimized growth production conditions and increased yields. > Suitable for GMP production > For use in autoclavable, sterilize-in- place or BioBLU® Single-Use Vessels www.eppendorf.com/Fibra-Cel Fibra-Cel® is a registered trademark owned by Imerys Minerals California, Inc., USA and licensed to Eppendorf, Inc., USA. Eppendorf®, the Eppendorf Brand Design and BioBLU® are registered trademarks of Eppendorf AG, Germany. All rights reserved, including graphics and images. Copyright © 2018 by Eppendorf AG. tmm_epp_ad_210x266_2018_04.indd 1 28.03.18 13:34 Online this Month The Power List The 2018 Power List, starting on page 24 of this issue, features 100 of the most inspirational professionals involved in A Scientist Walks into a Bar... format to the public”. Generally, drug development. The list was compiled it involves scientists speaking on a based on reader nominations and And gives a presentation as part variety of topics, from medicine, to feedback from a judging panel – but any of Pint of Science, a global science neuroscience, to robotics and more, in list will always be subjective.
    [Show full text]
  • List of Section 13F Securities
    List of Section 13F Securities 1st Quarter FY 2004 Copyright (c) 2004 American Bankers Association. CUSIP Numbers and descriptions are used with permission by Standard & Poors CUSIP Service Bureau, a division of The McGraw-Hill Companies, Inc. All rights reserved. No redistribution without permission from Standard & Poors CUSIP Service Bureau. Standard & Poors CUSIP Service Bureau does not guarantee the accuracy or completeness of the CUSIP Numbers and standard descriptions included herein and neither the American Bankers Association nor Standard & Poor's CUSIP Service Bureau shall be responsible for any errors, omissions or damages arising out of the use of such information. U.S. Securities and Exchange Commission OFFICIAL LIST OF SECTION 13(f) SECURITIES USER INFORMATION SHEET General This list of “Section 13(f) securities” as defined by Rule 13f-1(c) [17 CFR 240.13f-1(c)] is made available to the public pursuant to Section13 (f) (3) of the Securities Exchange Act of 1934 [15 USC 78m(f) (3)]. It is made available for use in the preparation of reports filed with the Securities and Exhange Commission pursuant to Rule 13f-1 [17 CFR 240.13f-1] under Section 13(f) of the Securities Exchange Act of 1934. An updated list is published on a quarterly basis. This list is current as of March 15, 2004, and may be relied on by institutional investment managers filing Form 13F reports for the calendar quarter ending March 31, 2004. Institutional investment managers should report holdings--number of shares and fair market value--as of the last day of the calendar quarter as required by Section 13(f)(1) and Rule 13f-1 thereunder.
    [Show full text]
  • A Balanced Trade Context for HIV Patent Pool
    iMedPub Journals 2011 TRANSLATIONAL BIOMEDICINE Vol. 2 No. 1:3 This article is available from: http://www.transbiomedicine.com doi: 10:3823/420 A Balanced Trade Context for HIV Patent Pool Daniele Dionisio, M.D. Member, European Parliament Working Group on Innovation, Access to Medicines and Poverty- Related Diseases. Reference Advisor for “Drugs for the developing countries”, SIMIT (Italian Abstract Society for Infectious and Tropical Diseases). Former Director, Infectious Disease Division, Pistoia city Hospital (Italy). Background: Reluctance of the multinational pharmaceutical companies to join the Medicines Patent Pool plan for HIV drugs (antiretrovirals-ARVs) might undermine E-mail: [email protected] its desirable objective of scaling up long-term, extended access to novel, affordable and appropriate ARV formulations in resource-limited settings. Methods: This paper makes an analysis of conflicting issues and calls for a trade context facilitating a reverse of multinational drug manufacturers’ reluctance to join patent pool. To this aim, partnerships between multinational companies are urged first to make cutting edge brand fixed-dose combination (FDC) ARVs promptly avail- able, and secondly, to allow patent pool agreements to be negotiated immediately afterwards. This context rejects clauses that exclude middle-income countries from sharing in the patent pool. Expected results: The suggested trade context can help speed up the partici- pation of originator pharmaceutical companies in the Medicines Patent Pool, while allowing them to maintain competitiveness, take advantage of incoming joint ven- ture opportunities and circumvent the need for additional incentives. This context potentially tackles in an appropriate way the directions of evolution in emerging markets, while bringing benefits to resource-limited populations, multinational drug corporations and manufacturers from middle-income countries.
    [Show full text]
  • The Path Less Costly
    COMMENtaRY CASE STUDY The path less costly Brady Huggett When faced with a competitive threat, two companies took diametrically opposite approaches. Both were ultimately successful, but Genzyme’s decision proved to be the cleaner and cheaper option. s the world’s leader in developing enzyme-replacement drugs, and Novartis of Basel. Houston-based Tanox was founded in 1986 to AGenzyme has always understood the importance of first to market. In focus on anti-IgE antibodies and by 1989 was looking for a clinical 1991, the company obtained approval for Ceredase (alglucerase injection), development partner; it sent samples of its candidate to both Genentech an enzyme replacement therapy for lysosomal storage disease (LSD) type and Ciba Geigy (the company that would later become Novartis). 1 Gaucher. Three years later, its second-generation product, Cerezyme Genentech passed. Ciba Geigy, however, began working with Tanox (imiglucerase for injection), was also cleared for commercialization. The on anti-IgE antibodies for allergic diseases. lack of treatments for lysosomal storage diseases and effective patient out- Yet Genentech clearly had interest in the area, because it began its own reach and marketing meant that Genzyme could command soaring prices anti-IgE program a few years later—a move that prompted a misappro- for its orphan treatments. In 2000, the two drugs alone provided 66% of priation suit from Tanox. The companies fought in court for three years Genzyme’s entire product revenue. before Genentech, Tanox and Novartis reached a settlement and entered At this time, Novazyme Pharmaceuticals was a young company devel- a cross-licensing agreement for anti-IgE antibodies.
    [Show full text]
  • Genentech 2002 Annual Report the Acceleration of Scientific Knowledge Over Time Has Been Profound— and It Is Ceaseless
    What we don’t yet know could change everything. Genentech 2002 Annual Report The acceleration of scientific knowledge over time has been profound— and it is ceaseless. Today, the span of time between great discoveries in medicine gets smaller and smaller due in part to the relatively new field of biotechnology. And the number of breakthroughs and new approaches to disease continues to grow. At Genentech, we believe we have only just begun to scratch the surface of biotechnology’s potential. Without a doubt, future discoveries will dramatically change our understanding of serious illnesses and potential treatments. Even more importantly, science is likely to create dramatic change at a more personal level— increasing the length and quality of life for our loved ones and ourselves. What if one day everyone could survive cancer? Cancer is the second leading cause of death in the United States behind heart disease, with over 1.2 million new cases diagnosed per year. Some predict it will become number one in the next 10 years. Curing cancer is our ultimate goal, but if we are able to keep cancer in check, extend patients’ lives and improve their quality of life, that will be a major victory over the disease. Genentech developed the first two therapeutic antibodies for cancer in the United States, Rituxan® (Rituximab), which was co-developed with IDEC Pharmaceuticals, and Herceptin® (Trastuzumab) — both of which attack malignant cells without causing extensive damage to healthy tissues. Rituxan and Herceptin are different from chemotherapy in that, although they are serious medicines, they tend to have relatively few side effects and can sometimes be taken for prolonged periods to stave off the disease.
    [Show full text]
  • Antibodies to Watch in 2021 Hélène Kaplona and Janice M
    MABS 2021, VOL. 13, NO. 1, e1860476 (34 pages) https://doi.org/10.1080/19420862.2020.1860476 PERSPECTIVE Antibodies to watch in 2021 Hélène Kaplona and Janice M. Reichert b aInstitut De Recherches Internationales Servier, Translational Medicine Department, Suresnes, France; bThe Antibody Society, Inc., Framingham, MA, USA ABSTRACT ARTICLE HISTORY In this 12th annual installment of the Antibodies to Watch article series, we discuss key events in antibody Received 1 December 2020 therapeutics development that occurred in 2020 and forecast events that might occur in 2021. The Accepted 1 December 2020 coronavirus disease 2019 (COVID-19) pandemic posed an array of challenges and opportunities to the KEYWORDS healthcare system in 2020, and it will continue to do so in 2021. Remarkably, by late November 2020, two Antibody therapeutics; anti-SARS-CoV antibody products, bamlanivimab and the casirivimab and imdevimab cocktail, were cancer; COVID-19; Food and authorized for emergency use by the US Food and Drug Administration (FDA) and the repurposed Drug Administration; antibodies levilimab and itolizumab had been registered for emergency use as treatments for COVID-19 European Medicines Agency; in Russia and India, respectively. Despite the pandemic, 10 antibody therapeutics had been granted the immune-mediated disorders; first approval in the US or EU in 2020, as of November, and 2 more (tanezumab and margetuximab) may Sars-CoV-2 be granted approvals in December 2020.* In addition, prolgolimab and olokizumab had been granted first approvals in Russia and cetuximab saratolacan sodium was first approved in Japan. The number of approvals in 2021 may set a record, as marketing applications for 16 investigational antibody therapeutics are already undergoing regulatory review by either the FDA or the European Medicines Agency.
    [Show full text]
  • Antiretroviral Treatment of Adult HIV Infection 2010 Recommendations of the International AIDS Society–USA Panel
    REVIEW CLINICIAN’S CORNER Antiretroviral Treatment of Adult HIV Infection 2010 Recommendations of the International AIDS Society–USA Panel Melanie A. Thompson, MD Context Recent data regarding the consequences of untreated human immunodefi- Judith A. Aberg, MD ciency virus (HIV) infection and the expansion of treatment choices for antiretroviral- Pedro Cahn, MD naive and antiretroviral-experienced patients warrant an update of the International AIDS Society–USA guidelines for the use of antiretroviral therapy in adults with HIV infection. Julio S. G. Montaner, MD Objectives To provide updated recommendations for management of HIV- Giuliano Rizzardini, MD infected adults, using antiretroviral drugs and laboratory monitoring tools available in Amalio Telenti, MD, PhD the international, developed-world setting. This report provides guidelines for when to initiate antiretroviral therapy, selection of appropriate initial regimens, patient moni- Jose´ M. Gatell, MD, PhD toring, when to change therapy, and what regimens to use when changing. Huldrych F. Günthard, MD Data Sources and Study Selection A panel with expertise in HIV research and Scott M. Hammer, MD clinical care reviewed relevant data published or presented at selected scientific con- Martin S. Hirsch, MD ferences since the last panel report through April 2010. Data were identified through a PubMed search, review of scientific conference abstracts, and requests to antiret- Donna M. Jacobsen, BS roviral drug manufacturers for updated clinical trials and adverse event data. Peter Reiss, MD, PhD Data Extraction and Synthesis New evidence was reviewed by the panel. Rec- Douglas D. Richman, MD ommendations were drafted by section writing committees and reviewed and edited by the entire panel.
    [Show full text]
  • DRUG INDUSTRY: Profits, Research and Development Spending
    United States Government Accountability Office Report to Congressional Requesters November 2017 DRUG INDUSTRY Profits, Research and Development Spending, and Merger and Acquisition Deals GAO-18-40 November 2017 DRUG INDUSTRY Profits, Research and Development Spending, and Merger and Acquisition Deals Highlights of GAO-18-40, a report to congressional requesters Why GAO Did This Study What GAO Found Retail prescription drug expenditures GAO’s analysis of revenue, profit margin, and merger and acquisition deals were estimated to account for about 12 within the worldwide drug industry from 2006 through 2015 identified key trends: percent of total personal health care service spending in the United States • Estimated pharmaceutical and biotechnology sales revenue increased in 2015, up from about 7 percent from $534 billion to $775 billion in 2015 dollars. through the 1990s. Much of this growth • About 67 percent of all drug companies saw an increase in their annual was driven by use of expensive brand- name drugs, but price increases have average profit margins from 2006 to 2015. Among the largest 25 been reported for some generic drugs companies, annual average profit margin fluctuated between 15 and 20 as well. Prior GAO reports have percent. For comparison, the annual average profit margin across non- identified multiple reasons for drug drug companies among the largest 500 globally fluctuated between 4 price increases, including limited and 9 percent. competition. Experts have questioned • The number of reported mergers and acquisitions generally held steady whether consolidation among drug during this period, but the median disclosed deal value increased. companies could reduce competition and R&D investment in new drugs.
    [Show full text]
  • Where Science Meets Life. Genentech 2006 Annual Report
    Where science meets life. Genentech 2006 Annual Report Header Genentech’s novel medicines are where cutting-edge science meets everyday life, where scientists working hard in labs intersect with individuals working hard to enjoy their lives while confronting serious and life-threatening illnesses. Our scientists and patients inspire each other and the rest of us at Genentech as we strive to develop therapies that dramati- cally improve the treatment options for people with critical medical conditions. On Cover: Ellen Filvaroff, Senior Scientist; Alex Alvarado, Nutropin AQ® Patient and Recipient of Free Medicine From the Genentech® Access to Care Foundation Our Mission Genentech’s mission is to be the leading biotechnology company, using human genetic information to discover, develop, manufacture and commercialize biotherapeutics that address significant unmet medical needs. The company is committed to high standards of integrity in contributing to the best interests of patients, the medical profession, our employees and our communities, and to seeking significant returns to our stockholders based on the continual pursuit of scientific and operational excellence. Letter to Stockholders Arthur D. Levinson, Ph.D. Chairman and Chief Executive Officer “We see tremendous advances in understanding the biological basis of many debilitating diseases, and we believe these advances play to Genentech’s greatest strengths as we try to translate the biology into new therapies.” Letter to Stockholders Dear Stockholders, I am happy to report that 2006 was another remarkable market for Genentech, the Lucentis launch was our most year for Genentech, with important developments across successful to date. Lucentis had U.S. sales of $380 million all areas of the business.
    [Show full text]
  • Quim. Nova, Vol. 30, No. 6, 1456-1468, 2007 QUÍMICA MEDICINAL MODERNA: DESAFIOS E CONTRIBUIÇÃO BRASILEIRA Lídia M. Lima Facu
    Quim. Nova, Vol. 30, No. 6, 1456-1468, 2007 QUÍMICA MEDICINAL MODERNA: DESAFIOS E CONTRIBUIÇÃO BRASILEIRA Lídia M. Lima# Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, CP 68006, 21944-910 Rio de Janeiro - RJ, Brasil MODERN MEDICINAL CHEMISTRY: CHALLENGES AND BRAZILIAN CONTRIBUTION. The main aspects of the modern Medicinal Chemistry, among the classic and industrial paradigms, used in the drug discovery process will be treated. The contribution of the Brazilian science in the knowledge generation in Medicinal Chemistry will be demonstrated, with base in searches accomplished in the portal Web of Science® 7.10 and in the directory of groups of research of CNPq. Keywords: medicinal chemistry; prototype; pharmaceutical industry. PREÂMBULO A etapa de otimização compreende o melhoramento da estrutu- ra do protótipo, através de modificações planejadas com auxílio de Neste artigo serão tratados, de forma não exaustiva, os aspec- técnicas definidas – que podem identificar os diferentes níveis de tos principais da Química Medicinal moderna, definindo as dife- contribuição farmacofórica, fornecer informações sobre a confor- renças e áreas de sobreposição entre os paradigmas clássico e in- mação bioativa e antecipar o índice de reconhecimento molecular dustrial aplicados ao processo da descoberta de fármacos. A inova- pelo alvo selecionado – visando o aumento da potência, seletividade, ção e a crise de produtividade nas indústrias farmacêuticas, asso- diminuição da toxicidade, adequação do perfil farmacocinético (ab- ciada à característica específica do paradigma industrial, serão dis- sorção, distribuição, metabolismo, excreção e toxicidade, ADMET) cutidas. Estratégias modernas para a identificação do composto- e estabelecimento da SAR, a partir da síntese e avaliação farma- protótipo, etapa-chave do processo da descoberta de fármacos e cológica, in vitro e in vivo, de séries congêneres ao protótipo iden- objetivo primário da Química Medicinal serão comentadas.
    [Show full text]
  • Inflammation Pharma 2017 Q2
    Q2: Quarterly Industry Update AS OF JUNE 30, 2017 Inflammation Pharmaceuticals INDUSTRY SUMMARY COGENT VALUATION identified Inflammation Pharma publicly traded companies, IPOs, and recent M&A transactions within the Inflammation Pharma industry, which provides a basis for market and transaction pricing that can be used by your firm in estimating market sentiment and its impact on your firm's value. Over the last year since June 30, 2016, the median 52-week share price return of the Inflammation Pharma industry was 27.9%. Between June 30, 2015 and June 30, 2017, the median EV/EBITDA multiple decreased from 12.5 to 11.8. However, the median price-to-earnings multiple increased from 20.5 to 27.5 over the same period. Median 52-Week Median 3-Year CAGR Median EV/Revenue Public Company Return Return Multiple Key Statistics 27.9% 11.4% 3.6x Median EV/EBITDA Median Price/Earnings Median EV/Gross CF Multiple Multiple Multiple 11.8x 27.5x 26.2x The disclosures and limitations of this research on page X are an integral part of this report. Copyright © 2017 Cogent Valuation. All Rights Reserved. COGENTVALUATION.COM | 1 INDUSTRY: Q2 2017 Inflammation Pharmaceuticals Comparable Public Company Market Price Returns as of June 30, 2017 YTD 3 Month 1 Year 2 Year 3 Year 2016 2015 2014 Abbott Laboratories 26.6% 9.5% 23.7% -0.5% 5.9% -14.5% -0.2% 17.5% Amgen Inc. 17.8% 5.0% 13.2% 5.9% 13.3% -9.9% 1.9% 39.6% Ampio Pharmaceuticals, Inc. -42.1% -34.9% -59.6% -53.1% -60.3% -74.3% 2.0% -51.9% Aquinox Pharmaceuticals, Inc.
    [Show full text]