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Steven G. Rozen, Ph.D. Curriculum Vitae Associate Dean of Research Informatics Professor, Cancer and Stem Cell Biology Program Duke-NUS Medical School

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Steven G. Rozen, Ph.D. Curriculum Vitae Associate Dean of Research Informatics Professor, Cancer and Stem Cell Biology Program Duke-NUS Medical School Steven G. Rozen, Ph.D. Curriculum Vitae Associate Dean of Research Informatics Professor, Cancer and Stem Cell Biology Program Duke-NUS Medical School Background Education Ph.D. Courant Institute of Mathematical Sciences at New York University, Computer Science (advisor: Dennis Shasha). Dissertation topic: automatic physical database design M.S. Courant Institute at New York University, Computer Science B.A. cum laude, University of California at Riverside Academic and Research Positions 2015-present Professor with tenure, Duke-NUS Medical School, Singapore 2016-present Associate Dean of Research Informatics, Duke-NUS Medical School, Singapore 2012-2021 Director, Duke-NUS Centre for Computational Biology 2008-2015 Associate Professor with tenure, Duke-NUS Medical School Singapore 2010-present Associate Professor Track V, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine 2019-present Joint appointment as professor, SingHealth Duke-NUS Global Health Institute 2015-present Research Scientist, National Heart Research Institute Singapore 2009-2021 Faculty Member, National University of Singapore Graduate School for Integrative Sciences and Engineering 2019-2021 Co-Advisor to SingHealth Strategy Group 9: Innovation and Digital Strategies. 2015-2018 Interim Chief Information Officer, PRISM (PRecISion Medicine Institute of SingHealth and Duke-NUS) 2014-2015 Visiting Scientist, National Heart Research Institute Singapore 1993-2008 Research Scientist (1994-2008) Whitehead Institute, Cambridge MA 1996-2008 Bioinformatics Consultant (part-time) 1999-2001 Director of yearly, intensive course, Bioinformatics: Writing Software for Genome Research, Cold Spring Harbor Laboratory, New York 1989-1993 Research Software Engineer, Software Options, Inc. (research funded by the Defense Advanced Research Projects Agency), Cambridge, MA 1988-1989 Graduate Assistant/Instructor, Department of Computer Science, Courant Institute at New York University, New York Other professional experience 1995-1997 Database consultant (part-time) Marble Associates Inc., Boston MA 1986-1988 Database architect and software engineer, Prudential-Bache Securities, New York 1983-1986 Information technology specialist and programmer, Chemical Bank, New York Page 1 Teaching and Mentoring 2018-present Director and faculty for the graduate-level course Core Concepts in Bioinformatics at Duke-NUS 2016-present Chair of Executive Committee of the Duke-NUS PhD Programme in Quantitative Biology and Medicine (QBM, https://www.duke- nus.edu.sg/education/our-programmes/phd/qbm-phd) 2017-present Duke-NUS Medical School, Singapore Ph.D. Programme in Quantitative Biology and Medicine (QBM); current students: WU Yang, JIANG Nanhai, HUANG Chen-Yang 2012–present Duke-NUS Medical School, Singapore Ph.D. Programme in Integrated Biology and Medicine; students: Mini HUANG (graduated 2017, looking for faculty position in China after a postdoc at the United States National Institutes of Health), Yuka Suzuki (graduated 2018, now working at Illumina), Mo LIU (graduated 2021, now doing a 1-year postdoc in the Rozen lab to complete a paper) 2016-2021 Postdoctoral fellow Arnoud BOOT, moving to a clinical genomics company in the Netherlands. 2009-2021 Faculty of the NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore; Ph.D. students: Thomas Thurnherr (co-supervised with Caroline Lee, graduated 2015), Alvin Ng (graduated 2018, now a postdoc at MRC Cancer Unit, Cancer Research UK, Cambridge Institute) 2009-2018 Postdoctoral fellow Yew Chung TANG (now at MiRXES Pte Ltd, Singapore, a biotech company) 2010-2017 Postdoctoral fellow John McPherson (now at Ab Initio Software) 2014-present Postdoctoral fellow Willie Yu 2015-2018 Postdoctoral fellow CHENG Shanshan; current position: Associate Professor, School of Public Health at Tongji Medical School of Hwazhong University of Science and Technology in Wuhan, China 2008-2014 Faculty of the Singapore-MIT Alliance, Programme in Computation and Systems Biology; Ph.D. students: Alice Yingting Wu (graduated 2013), Yujing Liu (graduated, 2014; co-supervised with Patrick Tan, now working at AstraZeneca in Shanghai) 2009-2013 Postdoctoral fellow Zhengdeng Lei; current position: Bioinformatics Specialist at the University of Chicago 2001-2001 Co-supervisor of PhD student Sjoerd Repping; current position: Chair, Healthcare Evaluation and Appropriate Use, Zorginstituut Nederland, (National Health Care Institute Netherlands) 2009-present Faculty of the 1st year medical course “Molecules to Tissues” at Duke-NUS Medical School 2010-2013 Faculty of the 1st year Ph.D. student core course “Molecules to Medicines” at Duke-NUS Medical School 1999-2001 Cold Spring Harbor Laboratory, New York, organized and directed course Bioinformatics: Writing Software for Genome Research, a course to train researchers in the creation and integration of software for genomics, genetics, and molecular biology; this two-week, intensive (all day and evening) course covered use of the Unix/Linux operating system, Perl programming, database design, creation of dynamic Web pages, and analysis of DNA sequence and gene expression microarray data; it was aimed at the needs of biologists with little or no prior hands-on experience in these areas Page 2 1992 International Conference on Very Large Data Bases, Database Tuning Tutorial (with D. Shasha) 1989 New York University, Courant Institute, Department of Computer Science taught graduate course Special Topics: Parallel Algorithms, Architectures, and Applications (with D. Shasha) 1988 New York University, Courant Institute, Department of Computer Science, taught undergraduate Introduction to Database Systems Current Grants as Principal Investigator Amount Amount Grant Title Funding Source Singapore $ Includes Dates US$ Indirect? Identifying oncogenic long non- 693,250 coding RNAs and short peptides Singapore Ministry of June 2018 to US$ direct in gastric cancer, MOE2017-T2-2- Education Aug 2021 ~510,000 009 The Singapore LYMPHoma Singapore National 100,000 (to May 2019 to TranslatiONal StudY Medical Research Rozen) direct April 2024 OFLCG18May-0028 Council US$ ~74,000 Systems for assessing mutation signatures in-vitro and discovering Singapore National 1,443,159 mutagenic exposures in tumors, direct and Feb 2019 to Medical Research US$~ MOH-000032/MOH-CIRG18may- indirect Jan 2022 Council (MOH) 1,063,709 0004 Current Grants as Co-Investigator or Mentor Amount Amount Singapore Includes Grant Title Funding Source Dates $ Indirect US$ ? Focal Therapy for Prostate Singapore S$ 375,000 Cancer: Does the Radiological- National Medical US$ direct TBA Molecular Landscape predict Research Council 275,463 Oncological Outcome 1 March CaLiBRe: Cancer Liquid Biopsy for S$ 360,000 2019 to Real-time diagnostics and Early A*STAR to Duke- direct 28 Feb Intervention NUS 2023 Page 3 Previous Grants Amount Amount Funding Grant Title Role Singapore $ Includes Dates Source US$ Indirect? Investigating the functional role Singapore and mechanism of action of National Sep 2018 MBNL1 in cancer, mentor Medical 250,000 direct to May NMRC/OFYIRG/0065/2017 Research 2021 (Deblina Ray) Council Impact of Noncoding Mutations Duke-NUS Associated with Cisplatin and Khoo Jun 2018 Aflatoxin B1 Mutagenesis on mentor Postdoctoral 150,000 direct to May Tumourigenesis, Duke-NUS- Fellow Award 2021 KPFA/2018/0027 (Arnoud Boot) Fund Singapore Epigenomic Profiling of Altered National 5,000,000 Apr 2016 Chromatin States in Co-I Medical US$ direct to Mar Gastrointestinal Cancer Research ~3,715,065 2021 NMRC/STaR/0026/2015 Council Integrating germline risk variants Singapore 1,290,000 into a clinically testable predictor National Aug 2016 US$ for sporadic colorectal Co-I Medical direct to Feb ~912,564direct carcinomas likely to metastasize Research 2020 only NMRC/OFIRG/0004/2016 Council Understanding the transcriptomic and epigenetic landscape of Apr 2017 Wilms tumor as a model of Collab. Philanthropy to Mar normal renal development and 2020 tumorigenesis Duke- Comprehensive genomic profiling Duke/Duke- NUS PI 100,000 (to Oct 2017 to determine the clonal origin and NUS (Duke Rozen) direct to July genetic evolution of recurrent Collaboration PI, Brant US$ ~74,000 2020 urothelial carcinoma Pilot Inman) Singapore Systems for assessing mutation National signatures in-vitro and 1,746,600 July 2015 Medical direct and discovering mutagenic exposures PI US$ to Jan Research indirect in tumors, ~1,245,000 2019 Council (CS- NMRC/CIRG/1422/2015 IRG) Page 4 Molecular atlas of hepatocarcinogenesis - longitudinal study to analyse the 300,000 Oct 2015 mutational and transcriptional SingHealth PI US$ direct to Sept changes during the development Foundation ~210,903 2018 of hepatocellular carcinoma, SingHealth/Duke- NUS/RCG/2015/0002 Integrating miRNA expression into a clinically testable predictor 300,000 Oct 2015 for early stage colorectal cancer SingHealth PI US$ direct to Sept likely to metastasize, Foundation ~210,903 2018 SingHealth/Duke- NUS/RCG/2015/0005 Singapore Discovery and validation of National July 2014 oncogenic splice variants as drug Medical 1,370,845 US$ PI direct only to June targets in gastrointestinal Research ~1,090,000 2018 cancers, NMRC/CIRG/1393/2014 Council (CS- IRG Singapore Alternative splicing networks in National Mar 2016 1,012,000 US$ gastric cancer, Co-I Medical direct only to Mar ~738,845 NMRC/CBRG/0104/2016 Research 2019 Council Singapore National Lymphoma Translational National Feb 2014 Research Program:
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