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Encyclopedia of Traditional Chinese Medicines - Molecular Structures, Pharmacological Activities, Natural Sources and Applications

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Encyclopedia of Traditional Chinese Medicines - Molecular Structures, Pharmacological Activities, Natural Sources and Applications Encyclopedia of Traditional Chinese Medicines - Molecular Structures, Pharmacological Activities, Natural Sources and Applications Vol. 3: Isolated Compounds H-M Bearbeitet von Jiaju Zhou, Guirong Xie, Xinjian Yan 1. Auflage 2011. Buch. xxxi, 669 S. Hardcover ISBN 978 3 642 16746 1 Format (B x L): 21 x 27,9 cm Gewicht: 4190 g Weitere Fachgebiete > Medizin > Sonstige Medizinische Fachgebiete > Pharmakologie, Toxikologie Zu Inhaltsverzeichnis schnell und portofrei erhältlich bei Die Online-Fachbuchhandlung beck-shop.de ist spezialisiert auf Fachbücher, insbesondere Recht, Steuern und Wirtschaft. Im Sortiment finden Sie alle Medien (Bücher, Zeitschriften, CDs, eBooks, etc.) aller Verlage. Ergänzt wird das Programm durch Services wie Neuerscheinungsdienst oder Zusammenstellungen von Büchern zu Sonderpreisen. Der Shop führt mehr als 8 Millionen Produkte. Volume 3 Isolated Compounds (H-M) J. Zhou et al., Encyclopedia of Traditional Chinese Medicines Molecular Structures, Pharmacological Activities, Natural Sources 1 and Applications: Vol. 3: Isolated Compounds H-M, DOI 10.1007/978-3-642-16747-8, © Springer-Verlag Berlin Heidelberg 2011 3 9191 Hainanensine H C17H17NO4 (299.33). Source: HAI NAN CU FEI Cephalotaxus hainanensis [Syn. Cephalotaxus mannii], SAN JIAN SHAN Cephalotaxus fortunei. Ref: 9186 Haemanthamine 660. 25 Hemanthamine [466-75-1] C17H19NO4 (301.35). mp 203~203.5ºC, [α]D = 25 O +19.7º (c = 3.8, methanol), [α]D = +33 (c = 1.25, CHCl3). Pharm: N Antihypertensive (mild); antiretroviral and cytotoxic (ID50 = 0.8μg/mL, TC50 O [5026] = 1.0μg/mL, TI50 (TC50/ID50) = 1.3) . Source: XUE PIAN LIAN O Leucojum vernum (bulb), family Amaryllidaceae spp. Ref: 658, 5026. OH 9192 Hainangenin O C27H44O5 (448.65). Source: JIAN MA Agave sisalana, WU CI FAN MA OH O Agave americana var. marginata [Syn. Agave americana var. variegata]. H H N Ref: 10. O 9187 Haemanthidine O Pancratine [466-73-9] C17H19NO5 (317.34). mp 189~190ºC (hemihydrate), [α] 22 = −41º (c = 1, CHCl ), Exists in solution as a mixture of C6 epimers. D 3 OH O Pharm: (−)-Haemanthidine activity: Cytotoxic (hmn prostate cancer LNCaP H H cell, ED50 = 0.7μg/mL; sarcoma cell HT, ED50 = 1.6μg/mL; A-431, KB, Lu1, ZR-75-1); analgesic (improved Koster trial, stronger than aspirin); sedative H H OH (mus, lengthens sleeping time induced by hexobarbital or pentobarbital.). H OH Source: GAN FENG CAO Zephyranthes candida, SHI SUAN Lycoris radiata [Syn. Amaryllis radiata]. Ref: 6, 1719, 1720, 1721. 9193 Hainanmurpanin 28 [95360-22-8] C17H18O6 (318.33). Crystals, mp 98~101ºC, [α]D = +7º H O (CHCl3). Source: JIU LI XIANG Murraya paniculata [Syn. Chalcas OH paniculata]. Ref: 11. O H H N O OH O O O 9188 Haematommic acid O O C9H8O5 (196.16). Source: JIN SI SHUA Lethariella cladonioides Ref: 660. O OH OH O 9194 Hainanolide O Harringtonolide [64761-48-4] C19H18O4 (310.35). Pale yellow crystals OH 30 (CH2Cl2−MeOH), mp 285~288ºC (dec), [α]D = +83.0º (c = 1.5, CHCl3); 9189 Haginin D mp 266~268ºC. Pharm: Cytotoxic (KB oral epidermoid carcinoma, ED50 = 2',4',7-Trihydroxyisoflavene C15H12O4 (256.26). Pharm: Antioxidant (rat 0.11μg/mL; Hep3B hepatoma cells, ED50 = 0.05μg/mL; HeLa, ED50 = [4253] brain homogenate lipid peroxidation test, IC50 = 0.2μmol/L, control EGCg, 0.37μg/mL) ; antineoplastic (L615, S180, W256, P388, L1210, and Lewis lung IC50 = 0.07μmol/L). Source: TONG XING LIE PIAN HU ZHI ZI Lespedeza cancer); antiviral (influenza virus, Newcastle disease virus, epidemic type-B homoloba. Ref: 2356. encephalitis virus and vaccinia virus, tissue culture model). Source: HAI OH O OH NAN CU FEI Cephalotaxus hainanensis [Syn. Cephalotaxus mannii], SAN JIAN SHAN Cephalotaxus fortunei, TAI WAN CU FEI Cephalotaxus wilsoniana (twig), ZHONG GUO CU FEI ZI Cephalotaxus sinensis [Syn. OH Cephalotaxus harringtonia var. sinensis], ZHONG GUO CU FEI ZHI YE 9190 Haginin E Cephalotaxus sinensis [Syn. Cephalotaxus harringtonia var. sinensis]. Ref: C15H12O3 (240.26). Amorphous powder. Pharm: Antioxidant (rat brain 658, 660, 4253. homogenate lipid peroxidation test, IC50 = 0.3μmol/L, control EGCg, IC50 = 0.07μmol/L). Source: TONG XING LIE PIAN HU ZHI ZI Lespedeza O homoloba. Ref: 2356. O H OH O H H O O H OH 4 9195 Hainanolidol 9200 Haloxyline A [73213-63-5] C19H20O4 (312.37). Source: HAI NAN CU FEI Cephalotaxus C27H49NO2 (419.70). Colorless crystals, mp 161~162ºC. Pharm: AChE hainanensis [Syn. Cephalotaxus mannii], SAN JIAN SHAN Cephalotaxus inhibitor (in vitro, IC50 = (25.3±0.02)μmol/L, control Galanthamine, IC50 = fortunei. Ref: 2, 660. (0.5±0.05)μmol/L); BChE inhibitor (in vitro, IC50 = (19.0±0.03)μmol/L, O control Galanthamine, IC50 = (8.5±0.01)μmol/L); antifungal (Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, O H Candida glabrata, Fusarium solani). Source: YAN JIAO CAO SUO SUO H H Haloxylon salicornicum (whole herb). Ref: 4460. O O O 9196 Hallactone A N [41787-72-8] C H O (346.38). Crystals, mp 266~268ºC (dec). Pharm: OH 19 22 6 Larvacide (toxic to larva of housefly). Source: HA SHI LUO HAN SONG 9201 Haloxyline B Podocarpus hallii. Ref: 658. C H NO (435.70). Colorless crystals, mp 142~143ºC. Pharm: AChE O 27 49 3 inhibitor (in vitro, IC50 = (20.2±0.01)μmol/L, control Galanthamine, IC50 = O O (0.5±0.05)μmol/L); BChE inhibitor (in vitro, IC50 = (14.7±0.02)μmol/L, control Galanthamine, IC50 = (8.5±0.01)μmol/L); antifungal (Trichophyton OH longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, H O Candida glabrata, Fusarium solani). Source: YAN JIAO CAO SUO SUO O Haloxylon salicornicum (whole herb). Ref: 4460. 9197 Hallactone B O [35470-59-8] C20H24O9S (440.47). Crystals, mp 325~330ºC (dec). Pharm: N Larvacide (toxic to larva of housefly). Source: HA SHI LUO HAN SONG OH Podocarpus hallii. Ref: 658. O OH O 9202 Hamamelitannin H [4415] S C20H20O14 (484.37). Pharm: 5-LOX inhibitor (IC50 = 1.0~18.7μmol/L) . O O O OH O Source: BAI GUO Ginkgo biloba, HONG LI Quercus rubra, MEI ZHOU H JIN LV MEI Hamamelis virginiana, OU ZHOU LI Castanea sativa. Ref: O O 660, 1521, 4415. 9198 Halophilol A OH C17H18O5 (302.33). Amorphous powder. Pharm: Cytotoxic (KB, IC50 = OH OH 17.28μmol/L; hmn microvascular endothelial cells HMEC, IC50 = 22.47μmol/L). OH Source: XI YAN YUAN WEI Iris halophila (seed). Ref: 5429. O OH O O OH O OH O OH O OH OH OH 9203 Hamanasic acid A O C15H24O3 (252.36). Source: MEI GUI HUA Rosa rugosa. Ref: 660. O OH H 9199 Halophilol B 25 C56H42O12 (906.95). Brown amorphous powder, [α]D = +152.4º (c = 1.28, OH MeOH). Pharm: Cytotoxic inactive (KB and HMEC). Source: XI YAN O YUAN WEI Iris halophila (seed). Ref: 5429. 9204 3'(R)-(+)-Hamaudol OH [204779-06-6] C15H16O5 (276.29). Yellow acicular crystals, mp 187~189ºC. OH OH OH Source: MA SHAN QIAN HU Peucedanum mashanens. Ref: 803. OH H H H H O OH O OH O H OH OH H OH H H O O O OH 5 9205 3'(S)-(−)-Hamaudol 9211 Hancinone C 25 [735-46-6] C15H16O5 (276.29). Needles (C2H5OH), mp 202~202.5ºC, [α]D C23H28O6 (400.48). Source: SHAN JU Piper hancei. Ref: 660. = −22.0º (c = 0.46, CHCl3). Source: FANG FENG Saposhnikovia divaricata O [Syn. Ledebouriella seseloides]. Ref: 2. O OH O O O OH O O O O 9206 Hamayne 9212 Hancogenin B Bulbispermine; Demethylcrinamine [61948-11-6] C16H17NO4 (287.32). C21H28O7 (392.45). Colorless acicular crystals (acetone), mp 202~203ºC. Pharm: AChE inhibitor (IC50 = (553±3)μmol/L, control Galanthamine, IC50 Source: HUA BEI BAI QIAN Cynanchum hancockianum. Ref: 237. = (1.9±0.2)μmol/L). Source: GUAN MU WEN SHU LAN Crinum macowanii. Ref: 4952. OH O OH O O H OH O OH H O N H O OH 9207 Hanburinone 28 9213 Hancokinol C34H42O11 (626.71). Yellow gum, [α]D = −62º (c = 0.09, CHCl3). Source: TENG HUANG SHU Garcinia hanburyi (fresh fruit). Ref: 4487. 25,26-Dinor-9,13-dimethyllup-5-en-3-ol [132294-77-0] C30H50O (426.73). Needles (MeOH), mp 229~230ºC, [α] 20 = +16.2º (c = 0.77, CHCl ); mp OH OH D 3 221~223ºC; colorless acicular crystals (chloroform), mp 223~225ºC. Source: O HUA BEI BAI QIAN Cynanchum hancockianum, LIU YE BAI QIAN O OH Cynanchum stauntonii. Ref: 510, 198, 1521. O O O H O O OH 9208 Hancinol H H H rel-(7S,8S,1'R,3'S,4'R)-1'-Allyl-7-(3,4-dimethoxyphenyl)-4'-hydroxy-5'-meth oxy-8-methyl-2'-oxobicyclo[3.2.1]oct-5'-ene [108864-50-2] C22H28O5 OH (372.47). Source: SHAN JU Piper hancei. Ref: 75. 9214 Hancolupenol C30H50O (426.73). Colorless acicular crystals, mp 184~185ºC (chloroform), 29 [α]D = +14.9º (c= 0.3, chloroform). Source: HUA BEI BAI QIAN O Cynanchum hancockianum. Ref: 198. O O H OH O 9209 Hancinone C20H20O5 (340.38). Source: SHAN JU Piper hancei, YU LAN Magnolia H H denudata [Syn. Magnolia heptapata]. Ref: 54, 660, 4439. OH O 9215 Hancolupenol octacosanate O O O C58H104O2 (833.47). Amorphous powder, mp 99~101ºC (chloroform). Source: HUA BEI BAI QIAN Cynanchum hancockianum. Ref: 198. O 9210 Hancinone B C21H24O5 (356.42). Source: SHAN JU Piper hancei. Ref: 660. OH H H O O O O O O 6 9216 Hancolupenone 9221 Hapepunine 3-O-α-L-rhamnosyl-(1→2)-β-D-glucopy- ranoside C30H48O (424.72). Colorless acicular crystals, mp 228.0~229.5ºC C40H67NO11 (737.98). Needles, +1H2O (MeOH aq.) mp 269~274ºC (dec), 29 (chloroform), [α]D = +14.9º (c = 0.2, chloroform). Source: HUA BEI BAI [α]D = −67.2º (c = 1.5, pyridine).
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