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Faculty of Health Sciences FACULTY OF HEALTH SCIENCERESEARCHS REPORT 2014-15 Rothko: Insert Faculty ‘snapshots’ here! Health Sciences STRATEGIC RESEARCH The 2014-15 Times Higher Education World University PLAN 2015 – 2020 th Rankings places UCT at 48th 48 for clinical, pre-clinical and Main aim: ‘to advance and encourage research excellence health universities within the FHS, within the context of the vision and mission of the Faculty and UCT, and thereby improve and promote our national and international standing as Accredited a research-led institution’ journal units Ultimate goal: to improve the health of the people of (Units are assigned to 528 South Africa and beyond accredited research outputs and translate into a total To be achieved through: improving research infra- monetary value) structure; building health research leadership and capacity for the future; enabling translation of research into public health impact; encouraging partnerships; increasing funding; strengthening governance and raised via raising standards 879 R684 contracts million (income increased by BENCHMARKING 23 percent from 2013) 10 NRF A-rated scientists 122 rated researchers (34 B-, 55 C-, 23 Y-rated) out of UCT’s 480 New Neurosciences A-rating awarded in 2014 Initiative Professor Robert Wilkinson (director of the launched in partnership with Groote Clinical Infectious Diseases Research Initiative, Schuur academic hospital complex to advance care and transform research IDM and Department of Medicine) and teaching by drawing together an P-rating awarded in 2015 array of expertise Dr Grant Theron (senior research officer in the Department of Medicine) UCT RESEARCH 2014-15 1 DST/NRF SARChI Internal AWARDS Chairs Professor Crick Lund (Department of Psychiatry and Mental Health) won UCT’s Alan Pifer Award in recognition of DST/NRF SARChI Chair vacancies outstanding welfare-related research filled: Professors Anthony Figaji Professor Gregory Hussey (director of Vaccines for Africa and (Department of Paediatric Neurosurgery) in acting dean) elected to UCT College of Fellows Clinical Neuroscience; Graeme Meintjes Honorary Professor William Pick (School of Public Health and (Department of Medicine) in Lung Infection Family Medicine) awarded President of Convocation Medal (2014) and Immunity; Stefan Barth (Department of Clinical Laboratory Sciences) in Cancer UCT College of Fellows Young Researcher Award: Dr Leigh Biotechnology Johnson (Centre for Infectious Disease Epildemiology Research) Newly awarded DST/NRF SARChI Chair: Professor Aqiel Dalvie (SA – External AWARDS Swiss Bilateral Research Chair in Global Environmental Health, School of Public 14 MRC (Medical Research Council) Strategic Health Health and Family Medicine) Innovation Partnerships Awards MRC Flagship Award to Professor Robin Wood (Department of Medicine and Director of the Desmond Tutu HIV Centre) MRC awarded Collaborating Centre for Malaria, a POSTGRADUATES, Gynaecological Cancer Research Centre, four Collaborating POSTDOCTORAL Centres for TB and/or HIV/AIDS, and a new MRC unit FELLOWS AND EMERGING MRC Platinum Medals for lifetime achievement awarded to RESEARCHERS Professors Gregory Hussey and Robin Wood (Department of Medicine and director of the Desmond Tutu HIV Centre) Over 1 200 postgraduate students Three Silver Medals were awarded by MRC to recent postdoctoral researchers for scientific or capacity building contributions 514 FHS students received 862 funding 12 researchers received NRF Career Advancement Fellowships awards to the value of over R47 million NRF Lifetime Achievement Award: Professor Lionel Opie 54 doctoral graduates – the highest (Hatter Institute of Cardiovascular Research) number yet in one academic year World Lung Health Award: Professor Heather Zar (Department 108 postdoctoral fellows, close to a third of Paediatrics) of UCT’s total World Hypertension League Award: Professor Brian Rayner (Department of Medicine) 176 fellowships totalling almost R24 million to postdoctoral fellows Wellcome Trust Senior Research Fellowship in Clinical Sciences: Professor Robert Wilkinson (Institute of Infectious 164 academics participated in UCT’s Disease and Molecular Medicine and Department of Medicine) Emerging Researcher Programme - the Academy of Science of South Africa Young Scientist Award: highest number from any faculty. Tenfold Dr Keren Middelkoop increase in participation from a decade ago Next Einstein Forum Fellowship: Dr Tolu Oni (School of Public Health and Family Medicine) 2 UCT RESEARCH 2014-15 DOCTORAL GRADUATIONS T. CARNEY (PSYCHIATRY) Evidence-based screening, brief intervention and referral M.-R.H. ABRAHAMS (MEDICAL VIROLOGY) to treatment for substance-using adolescents with The transmitted HIV-1 subtype C: characterization of delinquent-type behaviours the transmitted/founder full-length virus genome and Supervised by Associate Professor B. Myers and the influence of early immune selective pressure on Professor J. Louw virus replication N. CONRAD (MEDICAL BIOCHEMISTRY) Supervised by Professor C. Williamson Characterisation of the structural motifs Involved in A.O. ADEFUYE (MEDICAL BIOCHEMISTRY) the cleavage and secretion of human angiotensin- The role of seminal plasma in the regulation of converting enzyme inflammation and inflammatory pathways in the cervix: Supervised by Professor E. Sturrock and Ms S.L. potential for cervical cancer progression and HIV U. Schwager transmission in South African women M.B. CORNELL (PUBLIC HEALTH) Supervised by Dr K. Sales and Professor A.A. Katz The evolution and effectiveness of the South African S.K. ADJENTI (ANATOMY & CELL BIOLOGY) antiretroviral therapy program An investigation into the ultrastructural parameters of Supervised by Associate Professor L. Myer and Professor abdominal muscles in children and adolescents with M. Jeebhay spastic type cerebral palsy and the effect on postural S.M. COTTON (PSYCHIATRY) muscle performance Supervised by Professor G. Louw, Professor M. Jelsma Executive functioning in methamphetamine psychosis and Dr M. Unger Supervised by Professor D. Stein and Dr K.G.F. Thomas S. ALIWAINI (ANATOMY & CELL BIOLOGY) R. DENDERE (BIOMEDICAL ENGINEERING) Identification and characterization of a Novel Hand X-ray absorptiometry for measurement of bone Palladacycle, AJ-5, to treat advanced melanoma and mineral density on a slot-scanning X-ray imaging system breast cancer Supervised by Associate Professor T. Douglas and Supervised by Associate Professor S. Prince and Professor Dr S. Whiley S. Mapolie G.P. DESHPANDE (MEDICINE) B.W. ALLWOOD (MEDICINE) Testing metabolic and pharmacological agents for Tuberculosis-associated obstructive pulmonary disease recovery against de novo acute heart failure in an A clinical, radiological and pathophysiological study of isolated rat heart model the contribution of previous pulmonary tuberculosis Supervised by Professor L. Opie in a community-based study of patients with chronic O.B. DINTWE (CLINICAL SCIENCE obstructive pulmonary disease AND IMMUNOLOGY) Supervised by Emeritus Professor E. Bateman Characterisation of Mycobacterium tuberculosis specific L.B. ARENDSE (MEDICAL BIOCHEMISTRY) T cell immunity with HLA class II tetramers Exploring the effects of polymorphic variation on the Supervised by Dr T. Scriba and Dr E. Nemes stability and function of human cytochrome P450 N. DLAMINI (CELL BIOLOGY) enzymes in silico and in vitro The early inhabitants of the Upemba depression, the Supervised by Professor J. Blackburn Democratic Republic of Congo G.P. BANDAWE (MEDICAL VIROLOGY) Supervised by Professor A. Morris and Professor Understanding the interplay between HIV-1 diversity, J.C. Sealy humoral immune responses and viral fitness L. DU PLESSIS (BIOMEDICAL ENGINEERING) Supervised by Professor C. Williamson An investigation of components of the cerebellar- J.C. BROWN (EXERCISE SCIENCE) brainstem circuit involved in classical eyeblink Safer rugby through BokSmart? Evaluation of a conditioning in children with fetal alcohol nationwide injury prevention programme for rugby spectrum disorders union in South Africa Supervised by Associate Professor E. Meintjes Supervised by Professor M. Lambert, Professor W. Van R.G. ESSOMBA (CLINICAL SCIENCE & Mechelen, Dr E. Verhagen and Dr C. Draper IMMUNOLOGY) M.C. BURGER (EXERCISE SCIENCE) Generation, genetic and immunological characterization Genetic risk factors for carpal tunnel syndrome of subtype G envelope expressing HIV-1 pseudoviruses Supervised by Professor M. Collins Supervised by Dr J. Dorfman UCT RESEARCH 2014-15 3 N.M. FRANCISCO (CLINICAL SCIENCE & or at 6 weeks of age in Ugandan Infants IMMUNOLOGY) Supervised by Professor W. Hanekom, Dr B.M. Kagina, The role of cell type-specific tumour necrosisfactor in Dr C.L. Day and Professor H. Mayaja-Kizza protective immunity against neurotuberculosis G.J. MAARMAN (MEDICINE) Supervised by Associate Professor M. Jacobs Melatonin as a novel cardioprotective therapy in C.L. GRAY (PAEDIATRICS) pulmonary hypertension The prevalence and patterns of IgE-mediated food Supervised by Associate Professor S. Lecour and allergy and sensitisation in South African children with Professor K. Sliwa-Hahnle atopic dermatitis Supervised by Associate Professor M. Levin and Dr G. S. MARAIS (MEDICINE) du Toit Investigations into HIV-associated tuberculous meningitis M. HENDRIKSE (MEDICAL BIOCHEMISTRY) Supervised by Professor R.J. Wilkinson, Associate Professor G. Meintjes and Associate Professor Interactions of GPR54 and GPR147 receptors with RF- amide ligands K.A. Wilkinson Supervised by Professor A. Katz and Professor R.P. Millar
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