Diana M. Marangu – Mbchb, Mmed, MPH, Mphil, Phd July 2019

Diana M. Marangu – MBChB, MMed, MPH, MPhil, PhD July 2019

1) PERSONAL INFORMATION Name Diana Mwendwa Marangu OrcID http://orcid.org/0000-0003-3895-2210 Google Scholar https://scholar.google.com/citations?user=ReQlaT4AAAAJ&hl=en Address P. O. Box 55554-00200, Nairobi, Kenya Date of birth January 29, 1983 Phone +254 721 28 28 15 E-mail [email protected] Nationality Kenyan

2) PERSONAL STATEMENT I am passionate about improving respiratory health in children, nationally, regionally and globally. While pursuing an MPH in Global Health at the University of Washington, my colleague Dr. Nuttada Panpradist from Bioengineering and I conceptualized a point-of-care diagnostic for pulmonary TB (PTB) from urine samples. We convinced our supervisors that this was important and the collaborative effort resulted in a Global WACH/Coulter Foundation pilot grant award. My MPH thesis, a meta-analysis on the diagnostic accuracy of nucleic acid amplification tests in urine for PTB formed the literature review for this project, under the mentorship of Professors Grace John-Stewart and Beth Devine. Thereafter I embarked on a PhD in Tropical and Infectious Diseases and conducted research to optimize TB contact investigation in Nairobi (TB-Kwisha study) under the supervision of Professors Walter Jaoko, Elizabeth Obimbo, Deepa Rao, Joseph Babigumira and Grace John-Stewart. I then commenced my paediatric pulmonology training at Red Cross Children’s Hospital/University of Cape Town. During this fellowship, I undertook research on exogenous lipoid pneumonia (ELP) in African children. I reported the first case series on paediatric ELP in Africa, performed a systematic review to highlight the importance of recognizing this interstitial lung disease in children, and also participated in the development of an ELP preventive strategy in the Western Cape of South Africa, under the mentorship of Dr. Marco Zampoli, Dr. Aneesa Vanker, and Professors Diane Gray and Heather Zar. I have recently returned home to work with my fellow colleagues and the community to further optimize respiratory health, research and education in Kenya.

3) EDUCATION

14/12/2018 MPhil Paediatric Pulmonology, University of Cape Town, South Africa 25/10/2018 Certificate Paediatric Pulmonology (board certified by the Colleges of Medicine of South Africa) 14/09/2018 PhD Tropical and Infectious Diseases, University of Nairobi, Kenya 22/08/2014 MPH, University of Washington, Seattle, USA 07/12/2012 MMed Paediatrics and Child Health, University of Nairobi, Kenya 07/12/2007 Bachelor in Medicine and Surgery (MBChB), University of Nairobi, Kenya

4) POSITIONS AND EMPLOYMENT

Since 2018 Paediatric Pulmonologist, Department of Paediatrics and Child Health, University of Nairobi, Kenya 2016-2018 Paediatric Pulmonology Fellow, Department of Paediatrics, University of Cape Town, South Africa Since 2015 Lecturer, Department of Paediatrics and Child Health, University of Nairobi, Kenya 2014 Volunteer Intern, TB Control Program, Public Health Seattle and King County, Seattle, USA 2013-2018 Senior Fellow Trainee, International AIDS Research and Training Program, University of Washington, USA 2012-2015 Tutorial Fellow, Department of Paediatrics and Child Health, University of Nairobi, Kenya Since 2012 Paediatrician, Department of Paediatrics and Child Health, University of Nairobi, Kenya 2009-2012 Paediatrics Registrar, Department of Paediatrics and Child Health, University of Nairobi, Kenya 2009 Senior House Officer, Department of Paediatrics, Aga Khan University Hospital Nairobi, Kenya 2008 Medical Officer Intern, Department of Paediatrics, Aga Khan University Hospital Nairobi, Kenya

5) INSTITUTIONAL RESPONSIBILITIES

Mentoring and teaching undergraduate and postgraduate students in the Department of Paediatrics and Child Health, University of Nairobi. Providing paediatric and pulmonology clinical services at the Kenyatta National Hospital. Engaging and collaborating in research activities.

6) ONGOING RESEARCH PROJECTS 1. ‘Knowledge, attitude and practice of primary care physicians in Kenya, Nigeria and South Africa regarding obstructive sleep apnoea in adults and children.’ (KNH ERC P63-02-2016, Principal Investigator – Kenya) 2. ‘Point-of-care diagnosis of pulmonary TB from urine samples.’ Medical solutions to improve the health of women, children, and adolescents. Global WACh-W.H. Coulter Foundation Pilot Grants. http://depts.washington.edu/bioe/coulter-seed-grant-tb-diagnosis-urine/

Diana M. Marangu – MBChB, MMed, MPH, MPhil, PhD July 2019

7) SUPERVISION AT POSTGRADUATE AND UNDERGRADUATE LEVEL

Master students: ongoing: 6 (proposal), 2 (results); completed: 1.

Undergraduate students: ongoing: 2 (proposal).

8) TEACHING ACTIVITIES

1. Department of Paediatrics and Child Health, University of Nairobi: Undergraduate and postgraduate teachings including didactic lectures, bedside teachings, tutorials, mini-rounds and grand-rounds conducted throughout the year. 2. Systematic Review Methodology: Coordinating a 12-week course on systematic review methodology conducted annually for University of Nairobi, P-HERT fellows. 3. Respiratory Journal Club: Coordinating monthly journal club meetings addressing respiratory health topics for postgraduate students in the Department of Paediatrics and Child Health, University of Nairobi. 4. Institute of Tropical and Infectious Diseases, University of Nairobi: Postgraduate teachings on research methodology.

9) AWARDS

1. The Job Bwayo Award for Science in Lung Health in Kenya (2019) – received at the 5th Kenya International Scientific Lung Health Conference, Nairobi, Kenya. 2. ERS Travel Grant (2018) - Support to attend and make an oral poster presentation at the ERS annual conference in Paris. 3. PATS Travel Grant (2018) - Support to attend and give an oral presentation at the PATS conference in Durban, South Africa. 4. ERS Bursary (2017) - Partial support to attend the ERS Paediatric Pulmonology Summer School in Barcelona, Spain. 5. Margaret McNamara Education Grant Africa (2017) - Partial support for MPhil Paediatric Pulmonology Training at University of Cape Town, South Africa. 6. African Paediatric Fellowship Training Program Scholarship (2016-2018) - Partial support for MPhil Paediatric Pulmonology Training at University of Cape Town, South Africa. 7. World Society of Paediatric Infectious Diseases Travel Fellowship (2015) - Partial support to attend and make an oral presentation at the scientific conference in Rio, Brazil. 8. PATS Methods in Epidemiologic, Clinical and Operations Research (MECOR) Small Grant Level 1 (2015) – Awarded to our group to undertake a collaborative study entitled ‘Knowledge, attitude and practice of primary care physicians in Kenya, Nigeria and South Africa regarding obstructive sleep apnoea in adults and children.’ 9. World Health Organization (2014) - Support to make an oral presentation at a meeting to assess Live-Attenuated Influenza Vaccines to prevent paediatric influenza disease in low- and middle-income countries held on 16th -17th December 2014, in Geneva, Switzerland. 10. Centre for AIDS Research Trainee Support Grant (2014) - Partial support to attend the Advanced TB Diagnostic Research & TB Research Methods Workshops held at McGill University in Montreal, Canada. 11. International AIDS Research and Training Program Scholarship (2013-2018) – Support for MPH and PhD training 12. Young African Scientist Award (2013) - Support to attend and present a poster at the World Congress Paediatric Cardiology and Cardiac Surgery Conference held in Cape Town, South Africa. 13. Best Final Year Postgraduate Student in Paediatrics and Child Health (2012), University of Nairobi, Nairobi, Kenya. 14. Merit Awards (1997-2000) – Various academic merit awards, Kenya High School, Nairobi, Kenya

10) TRAININGS

1. PATS MECOR Training – Level 3 (Dar es Salaam, Tanzania): 09-14 June 2019 2. European Paediatric Life Support (EPLS), Full Instructor - Aga Khan University Hospital (2018) 3. PATS MECOR Training – Level 2 (Durban, South Africa): 16-20 April 2018 4. ERS Paediatric Bronchoscopy (Naples, Italy): 19-21 March 2018 5. University of Washington Courses - Survival Analysis, Advanced Health Services Research Methods II Hierarchical and Incomplete Data, and Statistical Methods for Spatial Epidemiology (Seattle, USA): 02 Jan-16 Mar 2018 6. ERS Paediatric Pulmonology Summer School (Barcelona, Spain): 6-8 Apr 2017 7. ERS Sleep Training Programme, Sleep and Breathing Conference (Marseille, France): 28 Jun–01 Jul 2017 8. PATS MECOR Training - Level 1 (Limuru, Kenya): 21-25 Sep 2015 9. EPLS Instructor Candidate - Aga Khan University Hospital (2015) 10. Emergency Triage and Treatment Plus (ETAT+) Full Instructor - University of Nairobi/KEMRI (2014) 11. TB Research Methods Workshop, McGill University (Montreal, Canada): July 14th – 18th 2014 12. 4th Advanced TB Diagnostic Research Workshop, McGill University (Montreal, Canada): July 7th – 11th 2014

Diana M. Marangu – MBChB, MMed, MPH, MPhil, PhD July 2019

11) ACTIVE MEMBERSHIPS IN SCIENTIFIC SOCIETIES

Since 2015 American Thoracic Society Since 2014 European Respiratory Society (ERS); International Union Against Tuberculosis and Lung Disease Since 2013 Respiratory Society of Kenya; Pan African Thoracic Society (PATS) Since 2012 Kenya Paediatric Association

12) CAREER INTENTIONS

SHORT TERM – Establish a pulmonology service for paediatric chronic respiratory diseases at Kenyatta National Hospital, Kenya’s leading tertiary and teaching hospital. Contribute to TB control in Nairobi County, Kenya through optimizing contact investigation and linkage to care in primary and secondary level health facilities. Participate in improving respiratory health among school-going children in Nairobi County, Kenya. MEDIUM TERM – Build research collaborations and become an independent researcher in the above-mentioned focal areas. LONG TERM – Professor in Paediatrics and Child Health, and a leader in paediatric respiratory health in Africa.

PUBLICATION LIST

A. Peer-Review Original Papers

1. Marangu D, Zar H. Childhood pneumonia in Low-and-Middle-Income countries: an update. Paediatric Respiratory Reviews. 2019. In press. https://doi.org/10.1016/j.prrv.2019.06.001 2. Marangu D, Gray D, Vanker A, Zampoli M. Exogenous lipoid pneumonia in children: a systematic review. Paediatric Respiratory Reviews. 2019. In press. https://doi.org/10.1016/j.prrv.2019.01.001 3. Katz MA, Marangu D, Attia EF, Bauwens J, Bont LJ, Bulatovic A, et al. Acute wheeze in the pediatric population: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine. 2019;37(2):392-9. 4. Marangu D, Pillay K, Banderker E, Gray D, Vanker A, Zampoli M. Exogenous lipoid pneumonia: an important cause of interstitial lung disease in infants. Respirology Case Reports. 2018;6(7):e00356. 5. Marangu D, Mwaniki H, Nduku S, Maleche-Obimbo E, Jaoko W, Babigumira J, et al. Adapting a stigma scale for assessment of tuberculosis-related stigma among English/Swahili-speaking patients in an African setting. Stigma and Health. 2017;2(4):326. 6. Marangu D, Mwaniki H, Nduku S, Maleche-Obimbo E, Jaoko W, Babigumira J, et al. Stakeholder perspectives for optimization of tuberculosis contact investigation in a high-burden setting. PLoS One. 2017;12(9):e0183749. 7. Russ CM, Ganapathi L, Marangu D, et al. Perspectives of host faculty and trainees on international visiting faculty to paediatric academic departments in East Africa. BMJ Global Health. 2016;1: e000097. 8. Marangu D, Devine B, John-Stewart G. Diagnostic accuracy of nucleic acid amplification tests in urine for pulmonary tuberculosis: a meta-analysis. Int J Tuberc Lung Dis. 2015;19(11):1339-47. 9. Marangu D, Kovacs S, Walson J, Bonhoeffer J, Ortiz JR, John-Stewart G, et al. Wheeze as an adverse event in pediatric vaccine and drug randomized controlled trials: A systematic review. Vaccine. 2015;33(41):5333-41. 10. Marangu D, Jowi C, Aswani J, Wambani S, Nduati R. Prevalence and associated factors of pulmonary hypertension in Kenyan children with adenoid or adenotonsillar hypertrophy. Int J Pediatr Otorhinolaryngol. 2014;78(8):1381-6.

B. Conference and Meeting Reports

1. Andreieva IO, Konstantynovska O, Midulla F, Marangu D, McHedlishvili N. Summer schools of adult and paediatric respiratory medicine: course report. Breathe (Sheffield, England). 2018;14(1):9-12.

C. Conference abstracts: manuscripts not yet published

1. Marangu D, Pillay K, Banderker E, Vanker A, Gray D, Zampoli M. Exogenous lipoid pneumonia in African children: a mixed- methods case series. European Respiratory Journal 2018;52:PA2238. 2. Marangu D, Jowi C, Aswani J, Wambani S, Nduati R. Diagnostic accuracy and feasibility of clinical-radiologic parameters for pulmonary hypertension in children with adenoid hypetrophy in echocardiography limited settings. ERJ open research 2017;3:P55.