Viruses 2012, 4, 3754-3784; doi:10.3390/v4123754 OPEN ACCESS viruses ISSN 1999-4915 www.mdpi.com/journal/viruses Review Use of the Syrian Hamster as a New Model of Ebola Virus Disease and Other Viral Hemorrhagic Fevers Victoria Wahl-Jensen 1,†,*, Laura Bollinger 1,†, David Safronetz 2, Fabian de Kok-Mercado 2, Dana P. Scott 2 and Hideki Ebihara 2 1 Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), National Interagency Biodefense Campus, B-8200 Research Plaza, Fort Detrick, Frederick, Maryland 21702, USA; E-Mail:
[email protected] 2 Integrated Research Facility at Rocky Mountain Labs, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 903 South 4th Street, Hamilton, Montana 59840, USA; E-Mails:
[email protected] (D.S.);
[email protected] (F.d.K.-M.);
[email protected] (D.P.S.);
[email protected] (H.E.) † These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail:
[email protected]; Tel.: +1-301-631-7248; Fax: +1-301-631-7389. Received: 14 November 2012; in revised form: 10 December 2012 / Accepted: 12 December 2012 / Published: 14 December 2012 Abstract: Historically, mice and guinea pigs have been the rodent models of choice for therapeutic and prophylactic countermeasure testing against Ebola virus disease (EVD). Recently, hamsters have emerged as a novel animal model for the in vivo study of EVD. In this review, we discuss the history of the hamster as a research laboratory animal, as well as current benefits and challenges of this model.