th Announcement April 13 , 2018

Indxx Global Longevity Thematic Index (ILNGR) would be reconstituted after the close of trading hours of April 20th, 2018.

Following constituents will be removed from the existing index:

S.No. ISIN Name 1 BMG0750W1047 Axovant Sciences Ltd 2 US2697961082 Eagle Pharmaceuticals, Inc 3 BE0003766806 Ion Beam Applications SA 4 GB00B01D1K48 Vectura Group PLC

Below are the new 100 stock index constituents effective as on close of trading hours of April 20th,2018.

S.No. ISIN Name 1 US00287Y1091 AbbVie, Inc. 2 US0036541003 ABIOMED, Inc. 3 US0042251084 ACADIA Pharmaceuticals Inc. 4 US00847X1046 Agios Pharmaceuticals, Inc. 5 US0162551016 Align Technology, Inc. 6 IE00B56GVS15 Plc 7 US0234361089 Amedisys, Inc. 8 US0311621009 Inc. 9 IT0004056880 Amplifon S.p.A. 10 US04269X1054 Array BioPharma Inc. 11 SE0007666110 Attendo AB 12 US0758871091 Becton, Dickinson and Company 13 US07725L1026 BeiGene Ltd. Sponsored ADR 14 US09062X1037 Inc. 15 FR0013280286 bioMerieux SA 16 US09609G1004 bluebird bio, Inc. 17 US09627Y1091 Blueprint Medicines Corp. 18 US1011371077 Boston Scientific Corporation 19 US1124631045 Brookdale Senior Living Inc. 20 US1510201049 Celgene Corporation 21 KR7068270008 Celltrion, Inc. 22 CA16141A1030 Chartwell Retirement Residences 23 JP3519400000 Chugai Pharmaceutical Co., Ltd. 24 US1894641000 Clovis Oncology, Inc. 25 AU000000COH5 Cochlear Limited 26 US23918K1088 DaVita Inc. 27 US24906P1093 DENTSPLY SIRONA, Inc. 28 US2521311074 DexCom, Inc. 29 US25456K1016 Diplomat Pharmacy, Inc. 30 US28176E1082 Edwards Lifesciences Corporation 31 SE0000163628 Elekta AB Class B 32 US29358P1012 Ensign Group, Inc. 33 US30063P1057 Exact Sciences Corporation 34 US30161Q1040 Exelixis, Inc. 35 US31572Q8087 FibroGen, Inc. 36 US3504651007 Foundation Medicine, Inc. 37 DE0005785802 Fresenius Medical Care AG & Co. KGaA 38 DK0010272202 A/S 39 US3773221029 Glaukos Corp 40 DK0010272632 GN Store Nord A/S 41 DK0010287234 H. Lundbeck A/S 42 US40637H1095 Halozyme Therapeutics, Inc. 43 US40414L1098 HCP, Inc. 44 US45337C1027 Incyte Corporation 45 US45780L1044 Inogen, Inc. 46 US45784P1012 Insulet Corporation 47 US45826H1095 Integer Holdings Corporation 48 US4579852082 Integra LifeSciences Holdings Corporation 49 US4622221004 , Inc. 50 JP3240600001 Kissei Pharmaceutical Co., Ltd. 51 FR0010386334 Korian SA 52 US5288723027 , Inc. 53 GB00BYMT0J19 LivaNova Plc 54 US5488621013 Loxo Oncology Inc 55 US5021751020 LTC Properties, Inc. 56 BMG570071099 Luye Pharma Group Ltd. 57 GB00BYNVD082 McCarthy & Stone PLC 58 IE00BTN1Y115 Medtronic plc 59 US5898891040 Merit Medical Systems, Inc. 60 JP3822000000 Miraca Holdings Inc. 61 JP3922800002 Mochida Pharmaceutical Co., Ltd. 62 US62855J1043 Myriad Genetics, Inc. 63 US63633D1046 National Health Investors, Inc. 64 US6390501038 Natus Medical Incorporated 65 JP3673600007 Nipro Corporation 66 DK0060534915 A/S Class B 67 JE00BYSS4X48 Novocure Ltd. 68 US6707041058 NuVasive, Inc. 69 TW0004174008 OBI Pharma, Inc. 70 US6819361006 Omega Healthcare Investors, Inc. 71 FR0000184798 Orpea SA 72 US74587V1070 Puma , Inc. 73 US7475451016 Quality Care Properties, Inc. 74 US74834L1008 Quest Diagnostics Incorporated 75 US7504692077 Radius Health Inc 76 US75886F1075 Regeneron Pharmaceuticals, Inc. 77 AU000000REG6 Regis Healthcare Ltd. 78 NZRYME0001S4 Ryman Healthcare Ltd. 79 US78573L1061 Sabra Health Care REIT, Inc. 80 US78667J1088 SAGE Therapeutics, Inc. 81 US8125781026 Seattle Genetics, Inc. 82 US81721M1099 Senior Housing Properties Trust 83 GB0009223206 Smith & Nephew plc 84 CH0012549785 Sonova Holding AG 85 US84763A1088 , Inc. 86 CH0012280076 Straumann Holding AG 87 US8636671013 Stryker Corporation 88 JP3546800008 Terumo Corporation 89 US8815691071 TESARO, Inc. 90 JP3602600003 Toho Holdings Co., Ltd. 91 BE0003739530 UCB S.A. 92 US92220P1057 Varian Medical Systems, Inc. 93 US92276F1003 Ventas, Inc. 94 US92532F1003 Incorporated 95 KR7084990001 ViroMed Co., Ltd. 96 US95040Q1040 Welltower, Inc. 97 DK0060738599 William Holding A/S 98 NL0011327523 Wright Medical Group NV 99 CH0019396990 Ypsomed Holding AG 100 US98956P1021 Zimmer Biomet Holdings, Inc.