PSTPIP1 Antibody Cat. No.: 56-465

PSTPIP1 Antibody

Flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti- rabbit secondary antibodies were used for the analysis.

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human

HOMOLOGY: Predicted species reactivity based on immunogen sequence: Mouse

This PSTPIP1 antibody is generated from rabbits immunized with a KLH conjugated IMMUNOGEN: synthetic peptide between 89-118 amino acids from the N-terminal region of human PSTPIP1.

TESTED APPLICATIONS: Flow, WB

For WB starting dilution is: 1:1000 APPLICATIONS: For FACS starting dilution is: 1:10~50

September 24, 2021 1 https://www.prosci-inc.com/pstpip1-antibody-56-465.html PREDICTED MOLECULAR 48 kDa WEIGHT:

Properties

This antibody is purified through a protein A column, followed by peptide affinity PURIFICATION: purification.

CLONALITY: Polyclonal

ISOTYPE: Rabbit Ig

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.

CONCENTRATION: batch dependent

Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Additional Info

OFFICIAL SYMBOL: PSTPIP1

Proline-serine-threonine phosphatase-interacting protein 1, PEST phosphatase-interacting ALTERNATE NAMES: protein 1, CD2-binding protein 1, H-PIP, PSTPIP1, CD2BP1

ACCESSION NO.: O43586

GENE ID: 9051

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

The protein encoded by this binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, negatively affecting CD2-triggered T cell activation. The encoded BACKGROUND: protein appears to be a scaffold protein and a regulator of the actin cytoskeleton. It has also been shown to bind ABL1, PTPN18, WAS, CD2AP, and PTPN12. Mutations in this gene are a cause of PAPA syndrome.

REFERENCES: 1) Andre, M.F., et al. Dig. Dis. Sci. 55(6):1681-1688(2010)

2) Rose, J. Phd, et al. Mol. Med. (2010) In press :

3) Hong, J.B., et al. J. Am. Acad. Dermatol. 61(3):533-535(2009)

4) Voss, M., et al. BMC Immunol. 10, 53 (2009) :

September 24, 2021 2 https://www.prosci-inc.com/pstpip1-antibody-56-465.html ANTIBODIES FOR RESEARCH USE ONLY.

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