Journal of Cancer 2021, Vol. 12 358 Ivyspring International Publisher Journal of Cancer 2021; 12(2): 358-370. doi: 10.7150/jca.47158 Research Paper Visualization and bibliometric analysis of cAMP signaling system research trends and hotspots in cancer Caoli Tang1, Duanya Liu1, Yongsheng Fan1, Jun Yu1, Cong Li1, Jianmei Su1,2 and Chunhong Wang1 1. Department of Preventive Medicine, School of Public Health, Wuhan University, Donghu Road 115, Wuhan 430071, Hubei, China. 2. Key Laboratory of Regional Development and Environmental Response, Faculty of Resources and Environmental Science, Hubei University, Friendship Avenue 368, Wuhan 430062, Hubei, China. Corresponding author: Department of Preventive Medicine, School of Public Health, Wuhan University, Donghu Road 115, Wuhan 430071, Hubei, China. E-mail address:
[email protected] (J. Su);
[email protected] (C. Wang). © The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. Received: 2020.04.18; Accepted: 2020.10.02; Published: 2021.01.01 Abstract Cyclic adenosine monophosphate (cAMP) is an essential second messenger that widely distributed among prokaryotic and eukaryotic organisms. cAMP can regulate various biological processes, including cell proliferation, differentiation, apoptosis and immune functions. Any dysregulation or alteration of cAMP signaling may cause cell metabolic disorder, immune dysfunction and lead to disease or cancer. This study aimed to conduct a scientometric analysis of cAMP signaling system in cancer field, and explored the research trend, hotspots and frontiers from the past decade. Relevant literatures published from 2009 to 2019 were collected in the Web of Science Core Collection database.