Endoplasmic reticulum protein TXNDC5 promotes renal fibrosis by enforcing TGFβ signaling in kidney fibroblasts Yen-Ting Chen, … , Shuei-Liong Lin, Kai-Chien Yang J Clin Invest. 2021. https://doi.org/10.1172/JCI143645. Research In-Press Preview Cell biology Nephrology Graphical abstract Find the latest version: https://jci.me/143645/pdf Endoplasmic Reticulum Protein TXNDC5 Promotes Renal Fibrosis by Enforcing TGF Signaling in Kidney Fibroblasts Yen-Ting Chen,1 Pei-Yu Jhao,1 Chen-Ting Hung,1 Yueh-Feng Wu,2,3 Sung-Jan Lin,2,3,4 Wen-Chih Chiang,5 Shuei-Liong Lin,2,5,6,7 Kai-Chien Yang1,2,8,9 1Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan 2Research Center for Developmental Biology & Regenerative Medicine, National Taiwan University, Taipei, Taiwan 3Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan 4Department of Dermatology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan 5Division of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan 6Department and Graduate Institute of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan 7Department of Integrated Diagnostics & Therapeutics, National Taiwan University Hospital, Taipei, Taiwan 8Division of Cardiology, Department of Internal Medicine and Cardiovascular Center, National Taiwan University Hospital, Taipei, Taiwan 9Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan Corresponding Author: Kai-Chien Yang, MD, PhD No.1, Sec. 1, Ren-Ai Rd, 1150R Taipei, Taiwan 100 Tel: +886-2-23123456 ext 88327; Fax: +886-2-23210976 Email:
[email protected] The authors have declared that no conflict of interest exists.