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Carvacrol: an Excellent Natural Pest Control Agent

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Carvacrol: an Excellent Natural Pest Control Agent s Chemis ct try u d & o R Bendre et al., Nat Prod Chem Res 2018, 6:6 r P e s l e Natural Products Chemistry & a DOI: 10.4172/2329-6836.1000349 r a r u t c h a N Research ISSN: 2329-6836 Commentary Open Access Carvacrol: An Excellent Natural Pest Control Agent Ratnamala Bendre1, Suresh Bagul1 and Jamatsingh Rajput1,2* 1Department of Chemical Sciences, Kavayitri Bahinabai Chaudhari, North Maharashtra University, Jalgaon, Maharashtra, India 2Department of Life Sciences, Kavayitri Bahinabai Chaudhari, North Maharashtra University, Jalgaon-425001, Maharashtra, India *Corresponding author: Jamatsingh Rajput, Department of Life Sciences, Kavayitri Bahinabai Chaudhari, North Maharashtra University, Jalgaon-425001, Maharashtra, India, Tel: +91 9673232264; E-mail: [email protected] Received: November 15, 2018; Accepted: November 29, 2018; Published: December 07, 2018 Copyright: © 2018 Bendre R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abstract Carvacrol is found especially in many angiospermic plants, also conjointly produced naturally by from Origanum vulgare, thyme, oil obtained from pepperwort, wild bergamot and essential oils isolated from some plants. It is having scientific value in the ayurveda, chinese medicine, western herbalism and modern sciences due to its biological and pharmacological activities. Besides, it plays a vital role in pest control. Present report emphasizes on carvacrol to exploit its pest management efficacy and potency. Keywords: Essential oil; Phenolic monoterpenes; Larvicidal; The effective functional group in carvacrol Ovicidal The biological activities of carvacrol are believed to be related to the functional group. It is suggested that the activities of carvacrol Introduction dependent upon the position of the hydroxy functional group and Environmental issues are circumscribing the employment of molecular configuration instead of volatility and molecular size traditional pesticides. Growing resistance of pests to present pesticides [11,12]. The most promising potential for exploitation of this molecule has given urgency to the look for better, safer compounds and safer as pest management chemical lies in the synthesis of derivatives and delivery systems. the necessity to treat a lot of exactly has conjointly analogs through simple synthetic procedures and through the provided additional opportunities for the utilization of natural establishment of structure-activity relationships. Throughout products [1]. Being tropical country India has a wealth of plants, that preliminary studies it had been discovered that with the knowledge of continues to be underutilized, apart from neem which is getting used the essential functional group, a molecule with high activity and from ancient time for inset management [2]. The rapid growth of specificity can be designed [13,14]. Thus, systematic derivatization of information of natural products, with biological activities towards carvacrol could prove it as both source and a model for new pests currently provides a choice for treatment and a basis for commercial pest management agents having a natural base in biorational approaches to the planning of pest management agents [3]. forthcoming time. Significantly over the past twenty-five years, there has been abundant activity directed to chemical work on isolation and identification of a Mode of action of carvacrol in pest large array of biologically active natural products that in same means Mode of action of carvacrol for various effects have not been affects the behavior, development and replica of pests and the growth determined but reports provide some clues for its possible specific of weeds [4,5]. Natural pheromones, antifeedants, insects and plant mechanisms [15]. Carvacrol exhibits several types of biological growth regulators have found commercial application, equally artificial activities in pests [16]. Carvacrol induce an immediate neurotoxicity analogs supported the natural products and have caught wider market and it is reported that hydrophobicity of compounds influences the [6]. penetration through the cuticle and piperonyl butoxide synergized the Carvacrol is a chemical compound found in numerous toxic effects [17]. Carvacrol also inhibits acetylcholinesterase. The angiospermic plants and herbs [7]. Carvacrol is a natural phenol, acetylcholinesterase inhibitory effect of carvacrol was found to be ten containing ten carbon unit having IUPAC name 5-isopropyl-2- time stronger than that exerted by its structural isomer thymol [18]. methylphenol and molecular formula C10H14O [8]. This molecule They act at the picrotoxinin site of the GABA (γ-aminobutyric acid) isomeric with thymol, is produced by Thymus, Thymbra, receptor-ionophore complex and as an antagonist of GABA, thus, Coridothymus, Satureja, oreganum and Lippia pepperwort, Origanum inhibiting the chloride uptake into the neuron through the chloride vulgare and Wild bergamot [9]. Carvacrol is what provides oregano a channel. Substituted carvacrol have been seen to elicit lindane like slightly spicy flavor, is colorless, and includes a distinct heat odor. GABA antagonistic effects. Carvacrol affects the sensory receptor of Carvacrol exhibits wonderful anti-microbial properties and makes it the insect in repellent activity [19]. helpful within the production of cosmetics, food preservatives and for treating diseases [10]. The focus of this case report is to highlight the No any harmful effect extensive effects of carvacrol on the various agricultural pest. There are no any known noxious effects of carvacrol, and it's been consumed by humans for many years suggesting that there's no toxic result [20]. Studies have conjointly shown that carvacrol is metabolized Nat Prod Chem Res, an open access journal Volume 6 • Issue 6 • 1000349 ISSN: 2329-6836 Citation: Bendre R, Bagul S and Rajput J (2018) Carvacrol: An Excellent Natural Pest Control Agent. Nat Prod Chem Res 6: 349. doi: 10.4172/2329-6836.1000349 Page 2 of 3 and excreted within twenty-four hours of consumption, which shows Acknowledgments that there is little risk of its increase within the body to any potential harmful level [21]. We are thankful to all those authors for publishing their research on carvacrol. Carvacrol in pest management References Natural phenols are having pest management strength against many agricultural as well as public health pests [22]. Carvacrol as insect- 1. Atal CK, Kapur BM (1982) Cultivation and utilization of medicinal control agents is reported by Tsao et al. where carvacrol and their plants. Jammu-Tawi, India. Regional Research Laboratory, Council of Scientific and Industrial Research. analogs have shown comparatively wide-ranging bioactivity against Hedin PA (1991) Naturally occurring pest bioregulators. Washington, agricultural and public health insect pests [23]. Carvacrol has been 2. DC:American Chemical Society. reported to have expressively enhanced larvicidal [24], ovicidal [25], 3. Prokopy R, Kogan M (2009) Integrated pest management. In acute and fumigant [26] activities against insects [27]. Carvacrol ethers Encyclopedia of Insects, pp: 523-528. showed better insecticidal action. Some of them displayed insect 4. Karuppuchamy P, Venugopal S (2016) Integrated pest management. In growth and development activity against mosquito larvae [28]. Ecofriendly Pest Management for Food Security, pp: 651-684. Carvacryl ethers and esters have been synthesized and evaluated as 5. Bale JS, Van Lenteren JC, Bigler F (2008) Biological control and antibacterial agents [29]. Our research group is working on simple sustainable food production. Philosophical Transactions of the Royal modification of carvacrol towards bioactive derivatives from 15 years Society of London B: Bio Sci 363: 761-776. [30,31]. A part of research work on carvacrol is on ether and ester 6. Mohankumar S, Ramasubramanian T (2014) Role of genetically modified derivatives and comprises of evaluation of antifungal, antibacterial insect-resistant crops in IPM: agricultural, ecological and evolutionary activities on plant pathogenic microorganisms as well as insecticidal implications. In Integrated Pest Manag, pp: 371-399. activities against stored grain pests [32]. Carvacryl esters were found to 7. Rajput JD, Bagul SD, Tadavi S, Bendre RS (2016) Comparative anti- be most active against plant pathogenic bacteria. Carvacryl acetate and proliferative studies of natural phenolic monoterpenoids on human carvacryl allyl ether exhibited similar antibacterial activity in malignant tumour cells. Med Aromat Plants 5: 2167-2412. comparison with standard streptomycin against A. radiobacter and P. 8. Bagul SD, Rajput JD, Tadavi SK, Bendre RS (2017) Design, synthesis and solanacearum [27]. biological activities of novel 5-isopropyl-2-methylphenolhydrazide-based sulfonamide derivatives. Res Chem Inter 43: 2241-2252. 9. Zade CM, Pete UD, Kadam MS, Bendre RS (2012) Development of Novel Future prospects Insect Growth Regulators: Effect of 1-(Substitutedbenzoyl)-3-[(2′- ′ Integrated Pest Management (IPM) is changing the scenario of Isopropyl-5 -Methylphenoxy) Acetamino] Thiourea and Urea Derivatives on Total Haemocyte Count of Dysdercus koenigii. In Chem Sustain today’s pest management. Plant products are rising as a viable part of Develop, pp: 69-79. IPM. The growing awareness of pesticide safety and government 10. Bagul
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