Medical A.Pects of an Orbiting Research Laboratory
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t Medical A.pects of an Orbiting Research Laboratory SPACE MEDICINE ADVISORY GROUP STUDY JANUARY TO AUGUST, 1964 S. P. VINOGRAD Scientafic and Tecbnicd Information Division 1966 NATIONAL AERONAUTICS AND SPACE ADMINISTRATION Washington, D.C. For Sale by the Superintendent of Documents, U.S. Government Printing Office, Washington, D. C. 20402 - Price $1 THE PRESENT VOLUME DESCRIBES how the to develop a research and development program that scientific comur.ity within the United States car- could point the way toward man's ultimate conquest ried out the first systematic investigation of the of the space environment. medical aspects of an orbiting research laboratory in The Mce of Space Medicine within NASA, and space. indeed the entire scientific community concerned with It wa?i a challenging project. Under Dr. Sher- the medical behavioral sciences, is indebted to Dr. man P. Vinograd's guidance, the Nationai Aero- Vinograd and to iiir group of wieiitists who gave 3 nautics and Space Administration brought together willingly of their time and effort toward furthering a group of leading medical scientists of the nation. the national goal of space exploration. These leaders applied their varied specialized compe- tence toward solving the potential problems that han JACK BOLLERUD would face as he left his earth bound environment Brigadier General, USAF, MC and moved into space, bringing their interdiscipli- Acting Director, Space Medicine nary and their interdepartmental viewpoints together Manned Space Flight THE SPACE MEDICINE ADVISORY GROUP (SPAMAG) is a group of consultants representing varied disciplines in the life sciences who met eight times to be briefed on the current status of the space program and to consider the various aspects of a pro- posed biomedical program of an orbiting research laboratory. This group was asked to consider the support recommendations under three broad categories: (1 ) life support, those environmental factors which are to be controlled or considered to be constant; (rj experiments in which environmental factors might be varied in a significant way in order to test the response in the space environment; and (3) research laboratory decision items which are related to the requirements for its design. The initial challenge to the Group is part of this report and lists the variety of environmental factors md ORL decisions which were discussed. In each of these areas, the Group was furnished a format as guidance in life support or experiment decisions. Additionally, the Space Medicine Advisory Group was divided into task groups so that they might address themselves to the spec& areas in which they had competence. These task groups are listed in the separate sections of the report. Priority assignment, in the context of this report, is an evaluation by the group for administrative purposes. The priority assessment is given on the basis of the degree to which consideration of the experiment was necessary in design of the research labora- tory and the degree to which the experiment required preliminary ground-based experi- mentation. Leadtime in terms of experiment design as well as the personnel involved is also a factor. In this respect it will be clear that the Group felt that all of the experi- ments were in a high priority category; that is, the experiments were necessary for con- sideration in design requirements as well as experimental planning at this time. A priority related to importance of the problem must be made at a later date. The report is given in three phases. Phase I on life support recommendations covers six categories: (1) hazards, (2) atmosphere, (3) living conditions, (4) meta- bolic factors, (5) group integrity, and (6) medical considerations. Under each of these categories the groups made recommendations concerning the spacecraft, research and development necessary for design of the spacecraft, ground-based experiments which were necessary for the design requirements, and, in some cases, experiments which should be accomplished in space flight preceding the orbiting research laboratory. The hazards section considers the toxicological and general housekeeping problems in the spacecraft. The atmosphere section prescribes the ideal atmosphere for a research laboratory and indicates the necessity for being able to change the atmosphere for experi- mental purposes. The living conditions section deals with general body functions and hygiene, decor, illumination and work schedules as well as volume requirements in the spacecraft. The metabolic requirements section sets forth the present day estimate of the food, water, and waste requirements. The group integrity section discusses those factors which are involved in efficient and harmonious group functioning; however, it does not consider in detail the previously well-studied topic of individual performance. The section on medical considerations addresses itself to recommendations concerning flight crew medical selection and considerations of illness and injury among the crew as well as recommendations for medical safety monitoring. V PRECEDING PAGE BLANK NOT FILMED. vi MEDICAL ASPECTS OF AN ORBITING RESEARCH LABORATORY These 6 sections represent a grouping of the some 15 items which were presented ' for discussion and considered individually. Phase I1 is concerned with the experiments. These experiments fall into three major categories; the first of which are those related to general medical and physiolog- ical measurements. Although a number of specific experiments are designed to test the characteristics of physiological and psychological systems, certain observations are rec- ommended on a continuous daily basis to provide data which may be used in a number of data acquisition and reduction procedures. These also will serve for the general medical monitoring in the spacecraft. Physiological tests cover experiments which are designed to test the characteristics of the cardiovascular system and the respiratory system. Additional experiments are designed to test and give indications of functions of overall metabolism, metabolism of bone and muscle and metabolism as related to hematology. A group of experiments which assess the neurologic function and miscellaneous experiments on the cellular level are also included. Although several stress factors were listed by the group for consid- eration, the experiments given are directed toward weightlessness and total combined flight stress. This does not negate the importance of the interaction of these factors, but it emphasizes the unique factor of weightlessness. Psychological experiments are devised to test the emotions, performance, reaction to frustration, and spontaneous activities. For Phase I11 on the design and operational recommendations, the ORL require- ments were gathered from a free discussion by the Group and relate to specific space- craft requirements, requirements for personnel in the spacecraft, and requirements for specific equipment in laboratory facilities on the spacecraft. The factors presented under the three phases of this report represent the present best opinion of the group with respect to the decisions and areas of emphasis for orbiting research laboratory considerations and give a general presentation which should be con- tinuously reevaluated and revised. Space Medicine Advisory Group Chairman Vinograd, S. P., M.D. Director, Medical Science and Technology Space Medicine Division, Office of Manned Space Flight NASA Headquarters, Washington, D.C. Co-chairman Karstens, Andres I., M.D. Assistant for Bioastronautics (MOL) Col., USAF, MC Aerospace Medical Division Los Angeles, Calif. Baldwin, Maitland, M.D. Clinical Director, NINDB, National Institutes of Health Bethesda, Md. Buesseler, John A., M.D. Chief of Ophthalmology University of Missouri School of Medicine Columbia, Mo. PREFACE vii Carlson, Loren D., Ph.D. Chairman, Dept. of Physiology and Biophysics University of Kentucky Medical Center Lexington, Ky. Deichmann, William B., Ph.D. Chairman, Dept. of Pharmacology University of Miami School of Medicine Coral Gables, Fla. Forster, Robert E., M.D. Professor, Physiology University of Pennsylvania Philadelphia, Pa. Gordon, Edgar S., M.D. Professor of Medicine University Hospital Madison, Wisc. Grahn, Douglas, Ph.D. Associate Division Director Division of Biological and Medical Research Argonne National Laboratory Argonne, Iil. Graybiel, Ashton, M.D. Director of Research Capt., USN, MC Naval School of Aviation Medicine Pensacola, Fla. Knoblock, Edward C. Director, Division of Biochemistry Lt. Col., USA, MSC Walter Reed Army Institute Washington, D.C. Kubis, Joseph F., Ph.D. Professor of Psychology Fordham University Graduate School New York City, N.Y. McFarland, Ross A., Ph.D. Guggenheim Professor of Aerospace Health and Safety Harvard School of Public Health Boston, Mass. Natelson, Samuel, Ph.D. Head, Dept. Biochemistry Roosevelt Hospital New York City, N.Y. Pollack, Herbert, M.D. Clinical Professor of Medicine George Washington University Institute for Defense Analyses Arlington, Va. Reitan, Ralph M., Ph.D. Director, Neuropsychology Section Indiana University Medical Center Indianapolis, Ind. c ... VI11 MEDICAL ASPECTS OF AN ORBITING RESEARCH LABORATORY + Schmitt, Otto H., PhD. Professor of Zoology and Biophysics University of Minnesota Minneapolis, Minn. Swisher, Scott H., M.D. Professor of Medicine University of Rochester, Rochester, N.Y. Townsend, John C., Ph.D. Professor, Department of Psychology Catholic University Washington, D.C. Warren, James V., M.D.