DOCSLIB.ORG

Cost-Effective, High-Yield Production System for Human- Like Blood-Clotting Factors for Haemophilia Therapy

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Cost-Effective, High-Yield Production System for Human- Like Blood-Clotting Factors for Haemophilia Therapy Technology Offer Cost-effective, high-yield production system for human- like blood-clotting factors for haemophilia therapy Summary An Austrian university has developed a production system in fungi to produce an enzymatically active recombinant blood clotting factor. These factors can essentially reduce the risk of blood infections during haemophilia therapy. The world-wide new development enables a stable production of blood clotting factors, cheaper and higher yielding than human-based factor concentrates. They are looking for industrial partners for licence agreements, commercial and technical cooperation agreements. Creation Date 29 May 2015 Last Update 22 July 2015 Expiration Date 21 July 2016 Reference TOAT20150529001 Details Description In the past 20 years recombinant blood clotting factors have been developed, reducing or eliminating the risk of blood-borne infections during haemophilia therapy. Today, recombinant factors are approved worldwide for therapy. They are normally produced in mammalian systems. Mammalian cell systems and their fermentation and purification process, and especially the extensive quality assurance and testing, contribute enormously to the cost of the final product. For mammalian expression systems, the fermentation procedure is expensive and yields are much lower than those reported for various microbial systems, i.e. fungi. Yeasts and other fungi represent promising alternatives, because they provide well-studied cheap systems and can be grown in chemically defined media without any animal derived material. However, yeasts and fungi are deficient in a system modifying proteins post- translationally in terms of gamma-carboxylation. So until now, they have not been able to produce recombinant blood-clotting factors. An Austrian university has genetically modified the model organism Aspergillus nidulans and demonstrated that gamma-carboxylated prothrombin can be expressed and purified efficiently from fungal fermentation broths. Moreover, biological activity of the fungal produced prothrombin and its accompanying functional gamma-carboxylation could be demonstrated in various activity assays. For the first time an engineered functional, heterologous Vitamin K dependent-protein (VKD protein) production system has been established. For the production of functional mammalian-like clotting factors, fungal cells have to be Page 1 of 608 Ref: TOAT20150529001 Printed: 24 July 2015 engineered, owing to their inability to post-translationally modify glutamate residues (=gamma- carboxylation) of VKD dependent proteins (i.e. clotting factors). The reaction is performed in the endoplasmic reticulum by VKD gamma-carboxylase and vitamin K epoxidase. Proper localization of the carboxylase and epoxidase was established and enzymatic activity of both gamma-carboxylase and vitamin K epoxidase was confirmed in vitro and in vivo. The system was patented and a PCT application was filed in 2014. Next it will be necessary to develop and optimize the system in industrially suitable production strains to increase yield and uniformity of the final product. 2010 the market for haemophilia therapy was about 5.6 billion US$ with a growth of 6.7 % between 2002 and 2010. It was therefore one of the fastest growing markets. The production of recombinant blood clotting factors will become more important in the next few years. There is a high market potential for a future product, with lower costs related to production and quality assurance. The Austrian university is looking for a commercial partner from industry to further develop and exploit the technology. This could be in the form of a commercial agreement with technical assistance, a technical cooperation agreement or a license agreement. The university will provide its expertise for the further development into an industrially applicable system. Advantages and Innovations For the first time an engineered functional, heterologous VKD-protein (Vitamin K dependent protein) production system was established, which is not based on mammalian cells. Advantages: - well-studied fungi production system, therefore well-known and stable factors of production - more cost-effective fermentation procedure and higher yields in comparison to mammalian systems - human-like carboxylated functional blood clotting factors, equals quality of mammalian derived blood-clotting factors but cheaper and with higher yields! Stage of Development Under development/lab tested Comments Regarding Stage of Development Complex system working since Q3/2013, novel data in Q3/2014 IPR Status Patent(s) applied for but not yet granted Profile Origin Other Keywords Technology 006001016 Pharmaceutical Products / Drugs 006002006 Microbiology 006002010 Enzyme Technology Page 2 of 608 Ref: TOAT20150529001 Printed: 24 July 2015 Market 005002005 Other therapeutic (including defibrillators) 005003006 Other medical/health related (not elsewhere classified) 005005 Anatomy, Pathology, Immunology, Physiology NACE P.85.4.1 Post-secondary non-tertiary education P.85.4.2 Tertiary education Network Contact Issuing Partner PECS-BARANYAI KERESKEDELMI ES IPARKAMARA Contact Person Enterprise Europe Network Hungary Pecs Email [email protected] Client Type and Size of Organisation Behind the Profile University Year Established 1872 Already Engaged in Trans-National Cooperation Yes Languages Spoken English German Client Country Austria Partner Sought Page 3 of 608 Ref: TOAT20150529001 Printed: 24 July 2015 Type and Role of Partner Sought Type of partner sought: Industry, commercial partner to further develop and exploit the technology. This could be in the form of a commercial agreement with technical assistance, a license agreement or a technical cooperation agreement. Specific area of activity of the partner: Production and development of blood-clotting factors (and other carboxylation-dependent proteins) Task to be performed by the partner: Develop and optimize the system in industrially suitable production strains to increase yield and uniformity of the final product. The university will provide its expertise for the further development into an industrially applicable system. Type and Size of Partner Sought SME 11-50,SME <10,>500 MNE,251-500,SME 51-250,>500 Type of Partnership Considered License agreement Commercial agreement with technical assistance Technical cooperation agreement Page 4 of 608 Ref: TOAT20150529001 Printed: 24 July 2015 Technology Offer Highly reliable and highly efficient magnetically geared wind generator technology Summary An Austrian SME has developed one of the world’s most effective magnetic gear boxes. It is based on a very simple and unique engineering concept with highest torque densities, ideal for application in wind turbines. The energy conversion is contactless, resulting in higher system reliability and efficiency. The company is looking for partners for technical cooperation, research-, commercial- and/or joint-venture agreements. It is also open to financial- or license agreements. Creation Date 02 July 2015 Last Update 06 July 2015 Expiration Date 05 July 2016 Reference TOAT20150702001 Details Description Existing problems in wind turbine designs Currently, the mainstream wind turbine system features a mechanically geared generator with a partially rated converter. In this setup, a gearbox is used to step up the input speed of the generator. As shown in several studies, these gear boxes suffer from the extreme torques produced by the rotor blades. Overall, the general perceived operational lifetime of frequently serviced gearboxes is only 7-11 years, versus 20-25 years design life of wind turbines. Gearbox failures account for the largest amount of downtime, maintenance and loss of power generation while further incurring high repair and replacement expenses. However, loads are expected to increase even further in the future due to ever increasing power demands on wind turbine plants. As a consequence, gearless wind turbine concepts like direct drive (DD) systems have been developed. While these wind turbine systems may present some technological advantages, the economic incentives for a shift from geared systems to direct-drive are still insufficient. The high cost and weight associated with DD-generators are a key deterring factor and have hindered their widespread use up to now. Engineering Solution Magnetic gears have been investigated as an alternative technology, both to mechanical gears and permanent magnet generators of DD-systems. While keeping the setup of a wind turbine with a mechanically geared generator, such an arrangement would replace the mechanical gearbox with a magnetic gear. This requires only minimal changes to the existing drive train while combining both the mass and cost advantages of geared systems and the improved reliability and robustness of direct drive systems. The magnetic gearing technology developed by the Austrian company replaces the cogwheels Page 5 of 608 Ref: TOAT20150702001 Printed: 24 July 2015 of a mechanical gearbox with elements consisting of magnetic pole-pairs. As opposed to the circular motion of cogwheels, the magnetic elements are rotating around each other at a slightly tilted angle, therefore creating a ‘wobbling’ motion – hence termed Magnetic Wobbling Gearing (MWG). The design completely eliminates the need for additional lubrication and allows for higher torque densities, more precision, more flexible gearing ratios and higher durability. The lack of mechanically interlocking parts in the gearbox further significantly reduces noise
Load more

Recommended publications
  • PROGRAM #Aiaascitech
    9–13 JANUARY 2017 GRAPEVINE, TX Addressing Full Spectrum Disruptions Across the Global Aerospace Community PROGRAM www.aiaa-SciTech.org #aiaaSciTech 17-4000 WHAT’S IMPOSSIBLE TODAY WON’T BE TOMORROW. AT LOCKHEED MARTIN, WE’RE ENGINEERING A BETTER TOMORROW. We are partnering with our customers to accelerate manufacturing innovation from the laboratory to production. We push the limits in additive manufacturing, advanced materials, digital manufacturing and next generation electronics. Whether it is solving a global crisis like the need for clean drinking water or travelling even deeper into space, advanced manufacturing is opening the doors to the next great human revolution. Learn more at lockheedmartin.com © 2014 LOCKHEED MARTIN CORPORATION VC377_164 Executive Steering Committee AIAA SciTech Forum Welcome Welcome to the 2017 AIAA Science and Technology Forum and Exposition (AIAA SciTech Forum) – the world’s largest event for aerospace research, development, and technology! Only here will you find the diversity of topics, caliber of speakers, and level of discourse about issues that directly impact your work, your career, and your industry – we are confident you will leave Grapevine prepared to shape the future of aerospace in new and exciting ways. Chuck Gustafson Jill Marlowe By bringing together 11 aerospace science and technology conferences, and by attracting attendees The Aerospace NASA Langley from across academia, industry, and government, AIAA SciTech will give you an unparalleled Corporation Research Center opportunity to hear from industry thought leaders, interact with your peers, and begin the inspired exchange of ideas that so often leads to breakthroughs in our community. Our organizing committee has worked hard over the past year to ensure that our plenary sessions examine some of the most critical issues facing aerospace today, especially the role that disruption plays in our community for better or worse.
    [Show full text]
  • CE-2017-417 Evaluation of the Effect of Variable Compression Ratios
    Article citation info: ALQAHTANI, A., WYSZYNSKI, M., MAZURO, P., XU, H. Evaluation of the effect of variable compression ratios performance on opposed piston 2-stroke engine. Combustion Engines . 2017, 171 (4), 97-106. DOI: 10.19206/CE-2017-417 Ali ALQAHTANI CE-2017-417 Miroslaw WYSZYNSKI Pawel MAZURO Hongming XU Evaluation of the effect of variable compression ratios performance on opposed piston 2-stroke engine Numerous skills involving the introduction of (OP) opposed piston engine have been developed in the recent past. Indeed, novel techniques can help to improve the performance of the engine. The aim of this paper is to model and simulate a simple single-cylinder two-stroke opposed-piston engine and minimise fuel consumption and heat loss, using the software programme AVL BOOST™. AVL BOOST is an engine modelling software, which analyses the performance of a modelled single cylinder two-stroke opposed-piston engine by changing desired parameters. In order to meet this aim, experimental results from a unique engine are used to make a comparison with the results obtained from AVL BOOST model. Six combinations of compression ratios (12, 13.5, 15, 16.5, 18 and 19.5) are analysed in this study with the engine speed running at 420 rpm and 1500 rpm. In addition to the compression ratios, the effect of stroke-to-bore (S/B) ratios on OP2S performance is investigated. Various values of S/B ratios, whilst maintaining a constant swept volume, port geometry and combustion timing, and their effect on fuel consumption and heat loss are analysed in this study. A comparison between the two engine speeds with increasing combinations of compression ratios, and the S/B ratios revealed minimal differences in peak pressure, peak temperature, IMEP, ISFC, indicated efficiency and total heat loss.
    [Show full text]
  • Emission Modelling and Model-Based Optimisation of the Engine Control
    Emission Modelling and Model-Based Optimisation of the Engine Control Vom Fachbereich Elektrotechnik und Informationstechnik der Technischen Universität Darmstadt zur Erlangung der Würde eines Doktor-Ingenieurs (Dr.-Ing.) genehmigte Dissertation von Dipl.-Math. Heiko Sequenz geboren am 29. April 1983 in Groß-Gerau Referent: Prof. Dr.-Ing. Dr. h. c. Rolf Isermann Korreferenten: Prof. Dr. rer. nat. Michael Kohler Prof. Dr.-Ing. Marius Pesavento Tag der Einreichung: 22. Oktober 2012 Tag der mündlichen Prüfung: 25. Februar 2013 D 17 Darmstädter Dissertationen III Danksagung Zunächst danke ich Prof. Isermann der durch die Finanzierung und durch zahlreiche Diskussionen zu meiner Forschungstätigkeit die Erstellung dieser Dissertation ermöglichte. Dank ihm erhielt ich einen tiefen Einblick in Forschungsthemen der Automobilindustrie, welche mich für meinen weiteren beruflichen Weg geprägt haben. Insbesondere danke ich ihm auch für die Möglichkeiten meine wissenschaftliche Ergebnisse auf nationalen und internationalen Konferenzen präsentieren zu können. Des Weiteren danke ich Prof. Kohler und Prof. Pesavento für die Übernahme des Korreferats. Ich freue mich, dass mit Prof. Kohler ein Korreferent des Fachbereichs Mathematik meine Arbeit von der mathematischen Seite bewertet hat, da dies die Grundlage dieser Arbeit und auch mein persön- licher Hintergrund ist. Auch Prof. Pesavento danke ich für die gewinnbringenden Anmerkungen zu den verwandten Modellbildungsverfahren. Ich möchte auch den Kollegen vom Institut für die stets angenehme Arbeitsatmosphäre danken, da gute Arbeit nur in einer solchen entstehen kann. Bei diesem Dank schließe ich sowohl die wis- senschaftlichen Mitarbeiter als auch die administrativen Angestellten mit ein, welche stets mit Rat und Tat im täglichen Arbeitsablauf zur Seite standen. Ich möchte an dieser Stelle insbesondere Mat- thias Mrosek danken, mit dem ich zahlreiche Diskussionen zu meiner Arbeit hatte und mit dem ich auch einige gemeinsame Veröffentlichungen erstellen konnte.
    [Show full text]
  • 17Th April, 2009
    ¯Öê™ëü™ü úÖµÖÖÔ»ÖµÖ úÖ ¿ÖÖÃÖúßµÖ •Ö−ÖÔ»Ö OFFICIAL JOURNAL OF THE PATENT OFFICE ×−ÖÖÔ´Ö−Ö ÃÖÓ. 16/2009 ¿ÖãÎú¾ÖÖ¸ ü פü−ÖÖÓú: 17/04/2009 ISSUE NO. 16/2009 FRIDAY DATE: 17/04/2009 ¯Öê™ëü™ü úÖµÖÖÔ»ÖµÖ úÖ ‹ú ¯ÖÏúÖ¿Ö−Ö PUBLICATION OF THE PATENT OFFICE The Patent Office Journal 17/04/2009 18429 INTRODUCTION In view of the recent amendment made in the Patents Act, 1970 by the Patents (Amendment) Act, 2005 effective from 01 st January 2005, the Official Journal of The Patent Office is required to be published under the Statute. This Journal is being published on weekly basis on every Friday covering the various proceedings on Patents as required according to the provision of Section 145 of the Patents Act 1970. All the enquiries on this Official Journal and other information as required by the public should be addressed to the Controller General of Patents, Designs & Trade Marks. Suggestions and comments are requested from all quarters so that the content can be enriched. ( P H Kurian ) Controller General of Patents, Designs & Trade Marks 17th April, 2009 The Patent Office Journal 17/04/2009 18430 CONTENTS SUBJECT PAGE NUMBER JURISDICTION : 18432-18433 SPECIAL NOTICE : 18434-18435 CORRIGENDUM (KOLKATA) : 18436 EARLY PUBLICATION (DELHI) : 18437-18440 EARLY PUBLICATION (MUMBAI) : 18441 PUBLICATION AFTER 18 MONTHS (DELHI) : 18442-18567 PUBLICATION AFTER 18 MONTHS (CHENNAI) : 18568-18632 PUBLICATION AFTER 18 MONTHS (KOLKATA) : 18633-18951 OPPOSITION U/S. 25(2) (KOLKATA) : 18952 PUBLICATION UNDER SECTION 43(2) IN : 18953 RESPECT OF THE GRANT (MUMBAI)
    [Show full text]
  • Preliminary Programme
    27th CIMAC World Congress on Combustion Engine Technology for Ship Propulsion Power Generation Rail Traction PRELIMINARY PROGRAMME 1 Contents 2 Welcome Message 4 Introduction to CIMAC 5 General Information 6 Time Schedule Overview 8 Conference Venue 9 Layout for Congress and Exhibition 13 Preliminary Programme Monday, 13th May 2013 15 Preliminary Programme Tuesday, 14th May 2013 19 Poster Session Tuesday, 14th May 2013 21 Preliminary Programme Wednesday, 15th May 2013 25 Poster Session Wednesday, 15th May 2013 27 Preliminary Programme Thursday, 16th May 2013 29 Poster Session Thursday, 16th May 2013 31 The Technical Programme Committee 33 Exhibition 34 Optional Tours Tuesday 14th May 2013 35 Optional Tours Wednesday 15th May 2013 36 Technical Tours Friday 17th May 2013 39 Optional Pre and Post Congress Tours 40 CHINA 41 Shanghai 43 Accommodation 44 Hotel Overview 45 Hotel Reservation 47 Registration information 50 Members of CIMAC 1 Welcome Message The Chinese Society for Internal Combustion Engines, as the National Member of CIMAC, has the pleasure of organizing the 27th CIMAC World Congress on Combustion Engines, scheduled for 13th – 16th May 2013 in Shanghai, China. CIMAC is a vigorous and attractive organization, which brings together manufacturers, users, suppliers, oil companies, classification societies and scientists in the field of engine. With more than 60 years of diligent, effective and valuable work, CIMAC has become one of the major forums in which engine builders and users can consult with each other and share concerns and ideas. The Congress will be devoted to the presentation of papers in the fields of marine, power generation and locomotive engine research and development covering state-of-the art technologies as well as the application of such engines.
    [Show full text]
  • Rapeseed Oil As Fuel for Farm Tractors
    RAPESEED OIL AS FUEL FOR FARM TRACTORS Prepared for IEA Bioenergy Task 39, Subtask „Biodiesel“ Prepared by BLT Wieselburg, www.blt.bmlfuw.gv.at A. Ammerer J. Rathbauer M. Wörgetter IEA Bioenergy August 12, 2003 RAPESEED OIL AS FUEL FOR FARM TRACTORS Prepared for IEA Bioenergy Task 39, Subtask „Biodiesel“ Prepared by BLT Wieselburg, www.blt.bmlfuw.gv.at A. Ammerer J. Rathbauer M. Wörgetter August 12, 2003 Published by: Manfred Wörgetter BLT – Bundesanstalt für Landtechnik Federal Institute of Agricultural Engineering Rottenhauserstr. 1, A 3250 Wieselburg [email protected] IEA Bioenergy, an international collaboration in Bioenergy, aims to accelerate the use of en- vironmentally sound and cost-competitive bioenergy on a sustainable basis, and thereby achieve a substantial contribution to future energy demands. The work of IEA Bioenergy is carried out through a series of Tasks, each having a defined work program. (www.ieabioenergy.com/) The objectives of Task 39 “Liquid Biofuels” are to work jointly with governments and industry to identify and eliminate non-technical barriers which impede the use of fuels from biomass in the transportation sector, and to identify technological barriers to Liquid Biofuels technolo- gies. The Task is composed of 10 members (Austria, Canada, Denmark, European Union, Finland, Ireland, The Netherlands, Sweden, USA and UK) interested in working together for a successful introduction of biofuels. Under the leadership of the US Department of Energy this Task reviews technical and policy issues and provides participants with information that will assist them with the development and deployment of biofuels for motor fuel use. (www.forestry.ubc.ca/task39/) The extent to which biofuels have entered the marketplace varies by country.
    [Show full text]
  • Experimental Assessment of the Performance and Emissions of a Spark-Ignition Engine Using Waste-Derived Biofuels As Additives
    energies Article Experimental Assessment of the Performance and Emissions of a Spark-Ignition Engine Using Waste-Derived Biofuels as Additives Joaquim Costa 1,2,* , Jorge Martins 1,* , Tiago Arantes 1, Margarida Gonçalves 3,* , Luis Durão 3 and Francisco P. Brito 1,* 1 MEtRICs, Department of Mechanical Engineering, Engineering School, Universidade do Minho, 4800-058 Guimarães, Portugal; [email protected] 2 Department of Mechanical Engineering, Universidade Nacional de Timor Lorosa’e, Dili, Timor Leste 3 MEtRICs, Department of Science and Technology of Biomass, Universidade Nova de Lisboa, 2825-149 Caparica, Portugal; [email protected] * Correspondence: [email protected] (J.C.); [email protected] (J.M.); [email protected] (M.G.); [email protected] (F.P.B.) Abstract: The use of biofuels for spark ignition engines is proposed to diversify fuel sources and reduce fossil fuel consumption, optimize engine performance, and reduce pollutant emissions. Ad- ditionally, when these biofuels are produced from low-grade wastes, they constitute valorisation pathways for these otherwise unprofitable wastes. In this study, ethanol and pyrolysis biogaso- line made from low-grade wastes were evaluated as additives for commercial gasoline (RON95, RON98) in tests performed in a spark ignition engine. Binary fuel mixtures of ethanol + gasoline or biogasoline + gasoline with biofuel incorporation of 2% (w/w) to 10% (w/w) were evaluated and compared with ternary fuel mixtures of ethanol + biogasoline + gasoline with biofuel incorporation Citation: Costa, J.; Martins, J.; rates from 1% (w/w) to 5% (w/w). The fuel mix performance was assessed by determination of torque Arantes, T.; Gonçalves, M.; Durão, L.; and power, fuel consumption and efficiency, and emissions (HC, CO, and NOx).
    [Show full text]
  • Commercial Truck/Equipment Technician. Occupational Competency Analysis Profile
    DOCUMENT RESUME ED 420 811 CE 076 833 TITLE Commercial Truck/Equipment Technician. Occupational Competency Analysis Profile. INSTITUTION Ohio State Univ., Columbus. Vocational Instructional Materials Lab. SPONS AGENCY Ohio State Dept. of Education, Columbus. Div. of Vocational and Adult Education. PUB DATE 1996-00-00 NOTE 82p.; For other profiles in this series, see CE 076 830-838. AVAILABLE FROM Center on Education and Training for Employment, The Ohio State University, 1900 Kenny Road, Columbus, OH 43210-1090 (catalog no. OCAP-24R, $10). PUB TYPE Guides - Classroom Teacher (052) EDRS PRICE MF01/PC04 Plus Postage. DESCRIPTORS Academic Standards; *Auto Mechanics; *Competence; Competency Based Education; Diesel Engines; Employment Potential; Entry Workers; Job Analysis; *Job Skills; Motor Vehicles; *Occupational Information; Postsecondary Education; Promotion (Occupational); Secondary Education; Small Engine Mechanics; Technology Education; *Vocational Education IDENTIFIERS DACUM Process; Occupational Competency Analysis Profile; Ohio ABSTRACT This Occupational Competency Analysis Profile (OCAP) for commercial truck and equipment technician is an employer-verified competency list that evolved from a modified DACUM (Developing a Curriculum) job analysis process involving business, industry, labor, and communityagency representatives throughout Ohio. The task list of the National Automotive Technicians Education Foundation (NATEF) makes up units 1-8 of the OCAP, covering the 8 truck areas that may be certified:(1) gasoline engines; (2) diesel engines;(3) drive train;(4) suspension and steering;(5) brakes; (6) electrical and electronic systems;(7) heating and air conditioning; and (8) preventive maintenance inspection. Unit 9 contains additional competencies important to the success of entry-level auto collision technicians in Ohio. Competencies for employability also are listed.
    [Show full text]
  • Parts & Services
    INDUSTRIAL SERVICES COMPANY PARTS & SERVICES 2017 CATALOG PRODUCT LINE WE OFFER FULL PRODUCT LINES FOR MANY LEADING COMPANIES 2 INDUSTRIAL SERVICES COMPANY | P 740.965.4112 F 740.965.5324 COMPANY INFORMATION INDUSTRIAL SERVICES COMPANY 146 Stelzer Court HOW TO PO Box 105 Sunbury, Ohio 43074 Telephone: (740) 965-4112 Fax: (740) 965-5324 ORDER http://www.ischughes.com E-mail: [email protected] or [email protected] PUMP REPAIR SERVICE Call for details on our repair services for your Wanner Hydra-Cell D-10, D-25, and H-25 pumps. Where appropriate, reconditioned parts may be available upon request. ABOUT US Industrial Services Company is a family owned and operated business serving the equipment & parts needs of the lawn care industry for over 27 years. We take pride in stocking necessary parts in order to fulfill same day shipping requirements to help keep our customers’ equipment downtime to a minimum. We continually add items to inventory to meet our customers’ needs and can accommodate requests for items not currently stocked. SHIPPING In stock orders placed before 3:00 pm (EST) are shipped same day. Next day, 2-day, and 3-day delivery options are available. CLAIMS & RETURNS Returns for credit must be received within 30 days of shipment and pre-approved by Industrial Services. After proper approval, original packing receipt or invoice must accompany return shipment regardless of reason for return. 3 INDUSTRIAL SERVICES COMPANY | P 740.965.4112 F 740.965.5324 99% OF ITEMS IN STOCK FOR SAME DAY SHIPPING We are a full national account equipment and parts dealer for all Turfco equipment.
    [Show full text]
  • R&D Technology Roadmap
    FUTURE ROAD VEHICLE RESEARCH R&D Technology Roadmap A contribution to the identification of key technologies for a sustainable development of European road transport Network initiated by CONTENT 1 EXECUTIVE SUMMARY Strategic Part A: 2 INTRODUCTION 2.1 Background of FURORE 2.2 Objectives and scope of FURORE technology R&D roadmap 2.3 Methodology and limitations 3 FUTURE SCENARIOS 3.1 Summary of current EU, member state and global policy 3.1.1 EU policy 3.1.2 EU member states policy 3.1.3 Other global policy 3.2 FURORE view on future road transport scenarios 3.2.1 Methodology 3.2.2 Targets, policy & scenarios for 2015-2020 3.2.2.1 Fuels and energy supply 3.2.2.2 CO2 and greenhouse gases 3.2.2.3 Emissions 3.2.2.4 Road safety 3.2.2.5 Traffic and congestion 3.2.2.6 Noise from road transport 3.2.2.7 Recycling 3.2.3 Influence of political climate 3.3 FURORE Targets up to 2020 and beyond 4 FUTURE BREAKTHROUGH TECHNOLOGIES 4.1 Introduction: The impact of future technologies on environmental, energy sources and socio-economic conditions 4.2 Energy and Fuels 4.3 Powertrain 4.3.1. Technology status for 2007 I CONTENT 4.3.2. Technology trends up to 2020 4.3.3. Technology visions beyond 2020 4.3.4. Research demand powertrain 4.4 Vehicle structure 4.4.1 Breakthrough technologies 4.4.2 Research demand 4.5 Safety 4.5.1 Passive Safety 4.5.2 Research Demand passive safety 4.5.3 Active Safety 4.5.4 Research Demand active safety 4.6 Noise, Vibration and Harshness 4.6.1 Exterior Noise 4.6.2 Research Demands Exterior Noise 4.6.3 Interior Noise 4.6.4 Research
    [Show full text]
  • Nummer 10/17 08 Maart 2017 Nummer 10/17 2 08 Maart 2017
    Nummer 10/17 08 maart 2017 Nummer 10/17 2 08 maart 2017 Inleiding Introduction Hoofdblad Patent Bulletin Het Blad de Industriële Eigendom verschijnt The Patent Bulletin appears on the 3rd working op de derde werkdag van een week. Indien day of each week. If the Netherlands Patent Office Octrooicentrum Nederland op deze dag is is closed to the public on the above mentioned gesloten, wordt de verschijningsdag van het blad day, the date of issue of the Bulletin is the first verschoven naar de eerstvolgende werkdag, working day thereafter, on which the Office is waarop Octrooicentrum Nederland is geopend. Het open. Each issue of the Bulletin consists of 14 blad verschijnt alleen in elektronische vorm. Elk headings. nummer van het blad bestaat uit 14 rubrieken. Bijblad Official Journal Verschijnt vier keer per jaar (januari, april, juli, Appears four times a year (January, April, July, oktober) in elektronische vorm via www.rvo.nl/ October) in electronic form on the www.rvo.nl/ octrooien. Het Bijblad bevat officiële mededelingen octrooien. The Official Journal contains en andere wetenswaardigheden waarmee announcements and other things worth knowing Octrooicentrum Nederland en zijn klanten te for the benefit of the Netherlands Patent Office and maken hebben. its customers. Abonnementsprijzen per (kalender)jaar: Subscription rates per calendar year: Hoofdblad en Bijblad: verschijnt gratis Patent Bulletin and Official Journal: free of in elektronische vorm op de website van charge in electronic form on the website of the Octrooicentrum Nederland.
    [Show full text]