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Clinical Presentation of Psoriatic Arthritis Among Sudanese: Hospital Based Study

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Clinical Presentation of Psoriatic Arthritis Among Sudanese: Hospital Based Study International Journal of Research Article Clinical Rheumatology Clinical presentation of psoriatic arthritis among sudanese: hospital based study Back ground: Psoriasis is a common papulo-squamous disorder affecting 2% of the population and Nasereldin Hamednalla Elasha is characterized by well demarcated red scaly plaques. Psoriatic Arthritis (PsA) may be defined as Hamednalla1,2,3,4, El nour an inflammatory arthritis which is seronegative for Rheumatoid Factor (RF) and enthesitis that is Mohammed El agib1, 2, Safi associated with psoriasis. The aims of our study is to identify different clinical presentations and Eldin Elnour Ali5, Mohammed types of psoriatic arthritis. Elmujtba Adam Essa*6 Methods: This is a descriptive cross sectional hospital based study conducted at Omdurman military 1Department of Internal Medicine and Rheumatology, Omdurman Military Hospital, hospital, Khartoum, Sudan, for a period of six months. The study included 96 patients confirm Omdurman, Khartoum, Sudan diagnosed by dermatologist as psoriasis, the data obtain with designed questionnaire contains the 2Department of Rheumatology, Sudan clinical presentations of the disease, lab result and radiological imaging, the study analyzed by SPSS Medical Specializations Board, Khartoum, v.20 by using one way a nova method to determine the P. value. Sudan 3Department of internal Medicine, Karary Results: From the total number of patients with Psoriasis, more than one third was psoriatic arthritis, University, Omdurman, Khartoum, Sudan 4Department of Internal Medicine, Ahfad 6% of patients with psoriatic arthritis were oligo-arthritis joint involvements, 14% were polyarthritis, university, Omdurman, Khartoum, Sudan 9% were distal inter phalangeal joint, 9% were spondylitis/sacroillitis and the remaining 5% were 5Department of Dermatology, Omdurman arthritis mutilants. Military Hospital, Omdurman, Khartoum, Sudan In conclusion:the study found out most common pattern of joint involvement in psoriatic arthritis is 6Department of Clinical Medicine, Medical oligoarthritis, which is not known to be common in psoriatic arthritis previously. and Cancer Research Institute, Nyala, Sudan Keywords: oligoarthritis ● psoriasis ● psoriatic arthritis ● sudan *Author for correspondence: [email protected] Introduction symptoms are more often insidious in onset, Psoriasis is a common papulosquamous rather than acute [4]. Joint discomfort, disorder affecting 2% of the population and more than pain, characterizes PsA. However, is characterised by well-demarcated red scaly asymptomatic disease, even with evidence of plaques. The skin becomes inflamed and hyper radiographic damage of the involved joints, is proliferates to about 10 times the normal not uncommon. rates. It affects male and females equally and There is no definitive test to diagnose psoriatic can affect all races. The age of onset occurs in arthritis as mostly the diagnosis is on a clinical two peaks [1, 2]. Early-onset (age 16 – 22) base. Although Symptoms of PsA may closely is commoner and it is often associated with resemble another disease such as rheumatoid a positive family history. Late-onset disease arthritis [5]. The aim of this study is to Study peaks at age 55 - 60 years [2, 3]. different clinical presentation of psoriatic arthritis among adult Sudanese patients. Psoriatic Arthritis (PsA) may be defined as inflammatory arthritis which is seronegative Material and methods for Rheumatoid Factor (RF) and enthesitis This is a descriptive cross sectional hospital that is associated with psoriasis. PsA has a based study, conducted at Omdurman Military worldwide Prevalence among psoriasis patients Hospital (OMH), Khartoum, Sudan. Between ranging from 6% to 42%. PsA is inflammatory the period of September 2015 to June 2016. arthritis in which initial musculoskeletal The study included 36 patients of psoriatic Int. J. Clin. Rheumatol. (2021) 16(4), 104-108 ISSN 1758-4272 104 Research Article Elasha Hamednalla NH, et al. arthritis from 96 patients of psoriasis. All the patients between 31-40 years by only 17% (Figure 1). The most were admitted or seen in referred clinic during the clinical presentations and types of psoriatic arthritis in study period who were diagnosed with psoriasis. Data this study was non-symmetrical oligo-arthritis in 61% was collected by using well-structured questionnaire of the total patients, followed by 14% with symmetrical retrieving information from the patients. A full detailed oligo-arthritis, 11% with distal interphalangeal joint, history was taken from the patients, after completion, 9% with spondylitis/sacroillitis and the fewest type the data were collected by using a designated questioner was arthritis mutilans in about 5% (Figure 2). In which contains: age, gender, symptoms and signs of the regard to the extra articular manifestations of PsA, the disease. Data were analyzed by using SPSS (Statistical study found that patients presented with nail changes, Package for Social Sciences). conjunctivitis and bowel symptoms. By 58%, 33% and Results 8% respectively. In This study we found that 61% of all the psoriatic Discussion arthritis patients are male, while the remaining 39% are Psoriatic Arthritis (PsA) has been defined as an female. Regarding the age related prevalence with the inflammatory arthritis, usually seronegative, associated diseases, are as follow; age group between 51-60 years with psoriasis. Among patients with psoriasis the have the highest affection by the disease with 33%, prevalence of inflammatory arthritis varies from 6% followed by age group from 61-70 years with 28%, then to 42% [6]. Thus, there is a distinct increase in the from 20-30 years by 19% and the least age group is those prevalence of inflammatory arthritis with varied patterns Age groups with Psoriatic Arthritis 40% 33% 35% 28% 30% 25% 61-70 years 19% 20% 17% 51-60 years 15% 31-40 years 20-30 years 10% 5% 0% 61-70 years 51-60 years 31-40 years 20-30 years Figure 1. Shows the age distributions between the patients of the study. 70% 61% 60% is t hri t 50% ar ic t ia 40% r 30% the pso f 20% 14% 11% ypes o 9% T 10% 5% 0% non-symmetrical symmetrical oligo- distal interphalangeal spondylitis/sacroillitis arthritis mutilans oligo-arthritis arthritis joint Figure 2. Shows the pattern and percentage of the disease between the patients. 105 Int. J. Clin. Rheumatol. (2021) 16(4) Clinical presentation of psoriatic arthritis among sudanese: hospital based study Research Article of presentation that are associated with psoriasis [7]. Among the recognized patterns of PsA initially described The current study was conducted among 96 patients by Moll and Wrights, the distal inter phalangeal joint diagnosed as psoriasis, and psoriatic arthritis was predominant pattern may be the most readily recognized detected among 36 patients. PsA can present with oligo- because it is unique to PsA, However occur in only 5% to articular joint involvement that is typically asymmetric 10% of patients. Nail lesions occur in 58% of the study or can present as polyarticular which is affecting more patients in contrary to other studies where they found than five joints, generally with a symmetric distribution more or less than 85% Nail changes on PsA patients. similar to that of rheumatoid arthritis [8,9]. This is due to the anatomical connection between the nail matrix and the enthesis of the distal interphalangeal This study identified that most common pattern of joint [13]. involvement in PsA patients is oligoarthritis. However, previous reports have indicated un-similar results as Conclusion polyarthritis is the most common presentation followed The most common pattern of joint involvement in by oligo-arthritis, distal involvement alone occurs psoriatic arthritis is asymmetrical oligoarthritis, Male in less than 20% of cases and may be associated with are commonly been affected than females, nail lesions spondyloarthritis, This may be due to some patients can occurs in 58% of patients with psoriatic arthritis, 33% presented with more than one pattern and may change of the patients with psoriatic arthritis has developed the pattern of their arthritis during follow up. While conjunctivitis. distal arthritis and arthritis mutilans are considered the Disclosure most specific for psoriatic arthritis, although, they are not commonly seen [10]. No conflict of interest. Funding The study also found that males were more affected by PsA than females by a ratio of 3:1, although gender- No fund have been received. related differences have not been thoroughly explored Ethical approval in PsA but some studies revealed that males accumulate A written consent was obtained from the patient and Sudan more axial and peripheral joints damage compared to federal ministry of health and Sudan Medical Specializations females [11], also some previous studies have addressed board. the potential role of hormonal influences in the Availability of data and materials pathogenesis of PsA [12], yet The explanation for these All the data used in the study are available from the first and differences is not fully understood. corresponding author on reasonable request. 106 Research Article Elasha Hamednalla NH, et al. References 7. Palmer D, Miedany YE. Early psoriatic arthritis: 1. Lebwohl MG, Bachelez H, Barker J et al. Patient facing the challenge. Br. J. Nurs. 22(17), 1014–1020 perspectives in the management of psoriasis: results (2013). from the population-based Multinational Assessment 8. Gladman DD. Clinical features and diagnostic of Psoriasis and
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