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Sclerocorneal Intrastromal Lamellar Keratoplasty for Pellucid Marginal Degeneration

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Sclerocorneal Intrastromal Lamellar Keratoplasty for Pellucid Marginal Degeneration TECHNIQUES Sclerocorneal Intrastromal Lamellar Keratoplasty for Pellucid Marginal Degeneration Damien Guindolet, MD,*†‡ Alexandra Petrovic, MD,* Serge Doan, MD,*†‡ Isabelle Cochereau, MD, PhD,*†‡ and Eric E. Gabison, MD, PhD*†‡ of the cornea,3 corneal surgeries try to correct the corneal Purpose: Surgical management of advanced pellucid marginal thinning and flattening of the vertical meridian with or degeneration is challenging. To correct both corneal thinning and without corneal graft. To preserve a patient’s endothelial induced corneal astigmatism, we propose a modified intrastromal layer, lamellar crescentic surgeries with4,5 or without lamellar sclero-keratoplasty. keratoplasty6–8 were developed. Intrastromal lamellar9 and 4,5 Methods: Corneal thinning was mapped using perioperative optical crescentic lamellar keratoplasty by addition of a donor coherence tomography (OCT). Then through a scleral tunnel, an lamellar cornea correct corneal thinning and indirectly astigmatism. The innovative intrastromal lamellar kerato- intrastromal pocket was created by stromal lamellar dissection under 9 m plasty published by Jabbarvand et al limits both astigma- OCT guidance. A 300 m-thick stromal lamellar graft was inserted fi in that pocket before closing the sclera to increase vertical tism and irregularity, but signi cant residual astigmatism median keratometry. often remains. Crescentic lamellar wedge resection removes the thinned part of the cornea, but extent of the resection Results: Intrastromal lamellar sclero-keratoplasty enabled corneal defines the correction of the astigmatism and can lead to – thinning correction and increased corneal astigmatism correction overcorrection.6 8 (211.6 diopters) without complications. Adapted from the Jabbarvand et al technique, we Conclusions: suggest an intrastromal lamellar sclero-keratoplasty correct- Intrastromal lamellar keratoplasty with scleral tunnel ing peripheral thinning and preserving the patient’s endo- fi is ef cient in PMD. Corneal thinning is corrected with the intra- thelial layer through a scleral tunnel, allowing an increase in stromal lamellar keratoplasty, and scleral tunnel closure allows the vertical meridian keratometry by tightening the stitches. increased corneal astigmatism correction. Perioperative OCT guid- We also benefit from material improvement with ance allows better detection of the diseased cornea and is helpful for perioperative optical coherence tomography (OCT). Until the lamellar dissection. now, detecting the thinned corneal area was based on Key Words: pellucid marginal degeneration, PMD, intrastromal preoperative topographic maps. Perioperative OCT helps to lamellar keratoplasty, keratoplasty, astigmatism define more accurately the borders of the corneal ectasia and can be helpful to monitor lamellar cut depth. (Cornea 2016;35:900–903) MATERIALS AND METHODS ellucid marginal degeneration (PMD) is a noninflamma- Ptory corneal ectasia with crescentic corneal thinning Surgical steps are displayed in Figure 1. Surgery was located approximately 1 mm from the limbus.1 The induced performed under general anesthesia and with perioperative flattening of the vertical meridian causes irregular astigma- OCT guidance (Rescan system; Zeiss). Limits of the tism with visual loss.2 Spectacles or contact lens are initial diseased tissue with corneal thinning were detected by perioperative OCT and marked with dermographic pen noninvasive options for visual rehabilitation. Toric intraocular fl lens (IOL) is a cornea-independent strategy to correct PMD- (Fig. 1A). A conjunctival ap was performed followed by related astigmatism; other surgeries involve the cornea.2 a 2-mm, half-depth scleral incision parallel to the limbus Aside from intracorneal ring segments that correct the shape over 10 mm (Fig. 1B). Then scleral tunnel and corneal lamellar dissection were performed centripetally toward the corneal center with a crescent knife through the previously Received for publication August 12, 2015; revision received January 15, delimited superior edge of corneal ectasia (Figs. 1C, D). A 2016; accepted January 15, 2016. Published online ahead of print April 7, 300-mm-thick corneal lamella was prepared using the Moria 2016. From the *Anterior Segment–Cornea Department, Fondation A. de Rothschild, ALTK microkeratome. The donor cornea was mounted on Paris, France; †HôpitalBichatClaudeBernard,Paris,France;and an artificial anterior chamber and, after epithelial removal, ‡Université Paris Diderot, Paris, France. a300-mm-thick stromal lamella was removed. We then The authors have no funding or conflicts of interest to disclose. placed the lamella above the host cornea. The marked edges Reprints: Eric E. Gabison, MD, PhD, Cornea and External Disorders, Hôpital Bichat and Fondation A. de Rothschild, Université Paris VII, Diderot, of the ectasia were clearly visible by transparency through Paris 75019, France (e-mail: [email protected]). the graft (Fig. 1E). The cutting edges were marked on the Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. donor corneal stroma in a crescent shape following the 900 | www.corneajrnl.com Cornea Volume 35, Number 6, June 2016 Copyright Ó 2016 Wolters Kluwer Health, Inc. Unauthorized reproduction of this article is prohibited. Cornea Volume 35, Number 6, June 2016 SILK for Pellucid Marginal Degeneration FIGURE 1. Perioperative OCT- guided surgical procedure. A, D, and H, Perioperative OCT imaging in the insert on the bottom right corner. A, Spotting and marking edges of the thinned cornea. B, Conjunctival flap and a 2-mm half-depth scleral inci- sion parallel to limbus with a cres- cent knife. C, Scleral tunnel and corneal lamellar dissection. D, Stro- mal dissection assessed with peri- operative OCT. E and F, Crescentic graft preparation. G, Placement of the stromal lamellar graft in its pocket. H, Sclera and conjunctiva suture. marks performed on the corneal pocket and then cut with contact lenses even before the occurrence of cataract. The Vannas scissors (Fig. 1F). The donor crescent-shaped visualacuitybeforesurgerywaslimitedtohandmotion.We corneal stroma was then inserted in the space created by agreed with the patient to first perform corneal surgery to stromal lamellar dissection (Fig. 1G). The sclera was improve corneal regularity and to subsequently perform subsequently sutured with 10/0 Nylon, and conjunctiva a cataract surgery with an appropriate toric IOL. Operative wasclosedwith2suturesof10/0Vicryl(Fig.1H). and postoperative surgical risks are identical to anterior lamellar graft (rejection, keratitis, and perforation). We explained the necessity to postpone the cataract surgery RESULTS waiting for stabilization of the astigmatism, but we also We describe a new technique of intrastromal corneal explained the possible astigmatism drift. The surgery was graft for the surgical management of a patient with PMD performed after the patient gave written informed consent. (Figs. 2, 3). Diagnosis of PMD was established on slit-lamp No perioperative or postoperative complications occurred. examination and corneal topography. The patient also had Postoperative treatment consisted of topical dexamethasone a dense cataract and reported poor visual acuity with his and tobramycin. The visual acuity after a 6-month follow-up Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. www.corneajrnl.com | 901 Copyright Ó 2016 Wolters Kluwer Health, Inc. Unauthorized reproduction of this article is prohibited. Guindolet et al Cornea Volume 35, Number 6, June 2016 FIGURE 2. Preoperative and post- operative slit-lamp examination and OCT. A, Preoperative slit-lamp examination with a slim beam. The cornea is irregular with flattened central area, thinned area located inferiorly, and a “beer-belly” aspect. B, Preoperative OCT imaging, verti- cal scan displaying the corneal thin- nest inferior part. C and D, Slit-lamp examination of the cornea 3 months after surgery. E, Three-month post- operative OCT imaging, vertical scan in the area of the stromal lamellar graft that displays increased corneal thickness in comparison with the preoperative one. C–G, Slit- lamp examination of the cornea 6 months after surgery. H, Six-month postoperative OCT imaging, vertical scan in the area of the stromal lamellar graft that displays increased corneal thickness in comparison with the preoperative one. was limited to count-fingers. Corneal topography was ative and postoperative flat keratometry varied from 29.8 to performed preoperatively and postoperatively after 6 37.6, and steep keratometry varied from 51.6 to 47.8, months. Corneal shape was more regular and corneal respectively. Corneal thickness after the surgery ranged astigmatism diminished (211.6 diopters) (Fig. 3). Preoper- from403to726mM(Fig.2). FIGURE 3. Preoperative, 6-month postoperative, and differential anterior sagittal image (Pentacam—Oculus). The stromal lamellar graft reduced corneal astigmatism to 11.6 diopters. 902 | www.corneajrnl.com Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. Copyright Ó 2016 Wolters Kluwer Health, Inc. Unauthorized reproduction of this article is prohibited. Cornea Volume 35, Number 6, June 2016 SILK for Pellucid Marginal Degeneration DISCUSSION anterior chamber. Nevertheless, the extent of lamellar dissec- This surgery has combined advantages of intrastromal tion is limited and we also used the perioperative OCT to keratoplasty described by Jabbarvand et al9 associated with monitor the depth of the dissection. Alternatively, preopera- a scleral
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