Deep Recurrent Conditional Random Field Network for Protein Secondary Prediction Johansen, Alexander Rosenberg; Sønderby, Casper Kaae; Sønderby, Søren Kaae; Winther, Ole Published in: ACM-BCB '17 DOI: 10.1145/3107411.3107489 Publication date: 2017 Citation for published version (APA): Johansen, A. R., Sønderby, C. K., Sønderby, S. K., & Winther, O. (2017). Deep Recurrent Conditional Random Field Network for Protein Secondary Prediction. In ACM-BCB '17: Proceedings of the 8th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics (pp. 73-78) https://doi.org/10.1145/3107411.3107489 Download date: 28. Sep. 2021 Session 3: Proteins and RNA Structure, Dynamics, and Analysis I ACM-BCB’17, August 20–23, 2017, Boston, MA, USA Deep Recurrent Conditional Random Field Network for Protein Secondary Prediction Alexander Rosenberg Johansen Casper Kaae Sønderby Technical University of Denmark, DTU Compute University of Copenhagen, Bioinformatics Centre
[email protected] [email protected] Søren Kaae Sønderby Ole Winther University of Copenhagen, Bioinformatics Centre Technical University of Denmark, DTU Compute
[email protected] [email protected] ABSTRACT methods [18] has emerged and received state of the art perfor- Deep learning has become the state-of-the-art method for predict- mance [6, 19, 26, 29, 31]. These approaches have arisen as the chal- ing protein secondary structure from only its amino acid residues lenge of annotating secondary protein structures is predictable from and sequence prole. Building upon these results, we propose to conformations along the sequence of the amino acid and sequence combine a bi-directional recurrent neural network (biRNN) with proles [29].