molecules Article Mentha pulegium L.: A Plant Underestimated for Its Toxicity to Be Recovered from the Perspective of the Circular Economy Lucia Caputo 1 , Laura Cornara 2 , Francesco Maria Raimondo 3, Vincenzo De Feo 1 , Stefano Vanin 2 , Marcella Denaro 4, Domenico Trombetta 4,* and Antonella Smeriglio 4 1 Department of Pharmacy, University of Salerno, via Giovanni Paolo II, 132, 84084 Fisciano (SA), Italy;
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[email protected]; Tel.: +39-090-676-6458 Abstract: The aim of the study was to investigate the micromorphology of Mentha pulegium leaves and flowers harvested in three different Sicilian (Italy) areas with peculiar pedo-climatic conditions, and to characterize the phytochemical profile, the phytotoxic activity, and the eco-compatibility of their essential oils (EOs) for potential use as safe bioherbicides. Light microscopy (LM) and scanning electron microscopy (SEM) highlighted that M. pulegium indumentum consists of non-glandular and Citation: Caputo, L.; Cornara, L.; glandular trichomes of different types. Peltate trichomes of plants from the different sites showed few Raimondo, F.M.; De Feo, V.; Vanin, S.; significant differences in dimension and abundance, but they were characterized by a surprisingly Denaro, M.; Trombetta, D.; Smeriglio, high number of secretory cells both in leaves and flowers.