Dr. Vojo Deretic – Chair: Dr. Dr. Mary Ann Osley – Dr. Robert Rubin– Professor: Dr. Michelle Ozbun – Dr. David Peabody – Deretic's main contributions to Professor: Dr. Osley’s Dr. Rubin’s lab explores T cell Professor: Dr. Ozbun’s lab Professor: Dr. Peabody was science come from studies by laboratory is focused on the tolerance and autoimmunity, T studies the cellular and viral trained at Stanford University his team on the role of role of chromatin in gene cell development in the mechanisms that regulate the in the laboratory of Paul Berg in and expression, DNA replication, thymus, systemic and drug- life cycles of papillomaviruses (Nobel Prize, 1980) and has (PVs), aiming to understand immunity. Autophagy, a cytoplasmic and DNA repair as cells enter induced lupus, & autoantibody been associated with UNM the delicate virus-cell interactions that can since 1984. For a number of years his pathway for the removal of damaged or and exit quiescence. Her research uses biosensors. Dr. Rubin’s laboratory also become unbalanced, leading to group studied RNA viruses of bacteria as surplus organelles, has been previously budding yeast, Saccharomyces cerevisiae, studies the cellular and molecular basis for malignancies. Three areas of research model systems to understand gene implicated in , , to study these cellular processes. the capacity of lupus-inducing drugs to interests are understanding: a) strategies development, and aging. Dr. Deretic's disrupt central T cell tolerance. regulation. In recent years his group has for PV infection and persistence; b) PV group is one of those that made the focused on adapting the virus-like particles and host interactions; c) the mechanisms discovery that autophagic degradation is a of these bacteriophages as platforms for of HPV-induced malignant transformation. major effector and a regulator of innate and vaccine discovery and delivery. adaptive immune mechanisms.

PMID: 19527881 PMID: 28122508 PMID: 26147502

Dr. Bryce Chackerian – Dr. Ellen Beswick– Dr. Judy Cannon – Associate Dr. Xuexian Yang – Dr. Kiran Bhaskar – Professor: Dr. Chackerian’s Associate Professor: Dr. Professor: Dr. Cannon’s Associate Professor: Dr. Assistant Professor: Dr. laboratory is focused on Beswick’s laboratory is research is focused on T cell Yang’s laboratory investigates Bhaskar’s research is related vaccine development. In interested in understanding migration, T cell signaling, and the regulation and function of T to understanding the role of particular, they use virus the relationship between leukemia cell migration using helper (Th17 and Th2) cells in neuroinflammation in chronic and Alzheimer’s disease (AD). particles as platforms for the gastrointestinal (GI) , developing in vivo imaging. Dr. Cannon’s inflammatory and autoimmune Display of antigens. Dr. Chackerian's novel immuno-therapeutics for GI cancer, T Group has visualized T cells moving in diseases, including neuro-inflammation, Importantly, his lab investigates the laboratory has demonstrated that antigens cell immunology in the GI tract, Treg and intact lymph nodes and lungs combined allergy, IBD and colon cancer. Dr. Yang’s inflammation cell-autonomous to microglia that are normally poorly immunogenic can Th17 differentiation and responses in GI with computational modeling to better group is also interested in transcriptional in driving AD-related pathologies, neuro- be made highly immunogenic by displaying cancers, Helicobacter pylori, Inflammatory understand immune responses. control in T cells and cytokine signaling degeneration and cognitive impairment in them in a multivalent, repetitive format on Bowel Disease. during adaptive immunity. various models of AD. the surface of virus particles -- essentially using viruses as platforms for vaccines. Isotype control anti-G-CSF antibody

PMID: 27389630 PMID: 26061815 PMID: 23727894

Dr. Michael Mandell – Assistant Dr. Kathryn Frietze – Research Dr. Paulus Mrass – Research Professor: Dr. Mandell’s research is Assistant Professor: Dr. Frietze’s Assistant Professor : Dr. Mrass’s focused on the autophagic targeting research aims to develop new research is focused on direct of HIV-1 by members of TRIM family technologies to assess antibody visualization and analysis of the of proteins (TRIMs). Dr. Mandell’s specificity and responsiveness in behavior of CD8+ effector T cells laboratory has determined that infectious and chronic diseases. at the site of inflammation TRIMs link autophagy induction with target Dr. Frietze’s laboratory is also interested in using cutting-edge imaging technology. The lab specificity. These dual functions can respond to translating the understanding of antibody also focused on direct in vivo visualization of T HIV infection promoting the clearance of viral responses into targeted therapeutic or cell migration and interaction with other components from the cell. The current focus of prophylactic interventions for various infectious immune cells during sterile lung inflammation the lab is to uncover how TRIMs and autophagy PMID: 27039982 PMID: 25127057 and chronic diseases. or infection with influenza virus. modulate HIV-induced immune signaling.