©2010 David Stultz, MD

MitralMitral valvevalve diseasedisease

DavidDavid Stultz,Stultz, MD,MD, FACCFACC SouthwestSouthwest Cardiology,Cardiology, Inc.Inc. SeptemberSeptember 28,28, 20102010 ©2010 David Stultz, MD ObjectivesObjectives

 IdentifyIdentify thethe principleprinciple causecause ofof mitralmitral stenosisstenosis  NameName severalseveral mechanismsmechanisms ofof mitralmitral regurgitationregurgitation  IdentifyIdentify howhow oftenoften mitralmitral regurgitationregurgitation shouldshould bebe followedfollowed byby echocardiogramechocardiogram ©2010 David Stultz, MD ThisThis ConferenceConference isis anan OverviewOverview

 ManyMany aspectsaspects cannotcannot bebe coveredcovered inin aa 11 hourhour conferenceconference  ThisThis isis meantmeant toto serveserve asas aa frameworkframework forfor furtherfurther knowledgeknowledge ©2010 David Stultz, MD OutlineOutline ofof conferenceconference

 MitralMitral StenosisStenosis  MitralMitral regurgitationregurgitation  MitralMitral valvevalve prolapseprolapse

 SurgicalSurgical andand endovascularendovascular repairrepair ©2010 David Stultz, MD

Libby P, Bonow RO, Mann DL, Zipes DP. Braunwald's Disease: A Textbook of Cardiovascular Medicine, Saunders, 2007. ©2010 David Stultz, MD SurgicalSurgical AnatomyAnatomy

Fedak PW, McCarthy PM, Bonow RO. Evolving concepts and technologies in . Circulation. 2008 Feb 19;117(7):963- 74. ©2010 David Stultz, MD MitralMitral StenosisStenosis  NarrowingNarrowing ofof thethe mitralmitral valvevalve orificeorifice  RestrictsRestricts flowflow fromfrom leftleft atriumatrium toto leftleft ventricleventricle duringduring diastolediastole  RheumaticRheumatic feverfever almostalmost alwaysalways thethe causecause  SenileSenile calcificcalcific (annular(annular calcification)calcification)  AnorecticAnorectic drugs,drugs, carcinoidcarcinoid  MitralMitral valvevalve areaarea normallynormally 44--6cm6cm2  2cm2cm2 isis mildmild stenosisstenosis  <1cm<1cm2 isis criticalcritical stenosisstenosis

Bonow RO, Carabello BA, Chatterjee K, de Leon AC Jr., Faxon DP, Freed MD, Gaasch WH, Lytle BW, Nishimura RA, O’Gara PT, O’Rourke RA, Otto CM, Shah PM, Shanewise JS. 2008 focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Valvular Heart Disease). J Am Coll Cardiol 2008;52:e1–142. Carabello BA. Modern management of mitral stenosis. Circulation. 2005 Jul 19;112(3):432-7. ©2010 David Stultz, MD

Libby P, Bonow RO, Mann DL, Zipes DP. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, Saunders, 2007. ©2010 David Stultz, MD SymptomsSymptoms ofof MitralMitral StenosisStenosis

 ExertionalExertional dyspneadyspnea  HemoptysisHemoptysis  ChestChest painpain  SystemicSystemic embolizationembolization  MostlyMostly duedue toto atrialatrial fibrillationfibrillation

Libby P, Bonow RO, Mann DL, Zipes DP. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, Saunders, 2007. ©2010 David Stultz, MD PhysicalPhysical ExaminationExamination forfor MSMS

 DiastolicDiastolic murmurmurmur  LowLow pitchedpitched rumblerumble atat apexapex withwith bellbell  BestBest heardheard inin leftleft laterallateral decubitusdecubitus positionposition  ProminentProminent S1S1 (If(If leafletsleaflets areare pliable)pliable)  OpeningOpening snapsnap  CausedCaused byby aa tensiontension onon thethe valvevalve leafletsleaflets whenwhen thethe valvevalve opensopens  AudibleAudible atat apex,apex, withwith bellbell ofof stethoscopestethoscope

 FollowsFollows AA2 byby 4040--120ms120ms  ShorterShorter AA2--OSOS intervalinterval == moremore severesevere MSMS

Libby P, Bonow RO, Mann DL, Zipes DP. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, Saunders, 2007. ©2010 David Stultz, MD PhonocardiogramsPhonocardiograms

http://en.wikipedia.org/wiki/File:Phonocardiograms_from_normal_and_abnormal_heart_sounds.png ©2010 David Stultz, MD SeveritySeverity ofof MitralMitral StenosisStenosis

Severity MVA Gradient PAP Symptoms Signs Therapy cm2 mmHg

Mild >1.8 2-4 Normal Usually absent S2-OS > 120ms; normal P2

Moderate 1.2-1.6 4-9 Normal Class II S2-OS Diuretics 100- 120ms; normal P2

Moderate 1.0-1.2 10-15 Mild Class II-III S2-OS 80- BMV if to Severe pulmonary 100ms; P2 applicable or HTN increase surgery if more than mild Sx

Severe <1.0 15 Mild to Class II-IV S2-OS BMV or surgery severe <80ms; P2 pulmonary increase; HTN RV lift

Carabello BA. Modern management of mitral stenosis. Circulation. 2005 Jul 19;112(3):432-7. (Adapted) ©2010 David Stultz, MD

MSMS AuscultationAuscultation

http://depts.washington.edu/physdx/heart/tech.html ©2010 David Stultz, MD AsymptomaticAsymptomatic MitralMitral StenosisStenosis

Bonow RO, Carabello BA, Chatterjee K, de Leon AC Jr., Faxon DP, Freed MD, Gaasch WH, Lytle BW, Nishimura RA, O’Gara PT, O’Rourke RA, Otto CM, Shah PM, Shanewise JS. 2008 focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Valvular Heart Disease). J Am Coll Cardiol 2008;52:e1–142. ©2010 David Stultz, MD MedicalMedical ManagementManagement

 DiureticsDiuretics  SaltSalt restrictionrestriction  AnticoagulationAnticoagulation ifif indicatedindicated  AtrialAtrial fibrillationfibrillation  TreatmentTreatment ofof atrialatrial fibrillationfibrillation

Libby P, Bonow RO, Mann DL, Zipes DP. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, Saunders, 2007. ©2010 David Stultz, MD MitralMitral StenosisStenosis ““HockeyHockey StickStick”” ©2010 David Stultz, MD MeanMean PressurePressure GradientGradient MitralMitral StenosisStenosis ©2010 David Stultz, MD SymptomaticSymptomatic MitralMitral StenosisStenosis

Bonow RO, Carabello BA, Chatterjee K, de Leon AC Jr., Faxon DP, Freed MD, Gaasch WH, Lytle BW, Nishimura RA, O’Gara PT, O’Rourke RA, Otto CM, Shah PM, Shanewise JS. 2008 focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Valvular Heart Disease). J Am Coll Cardiol 2008;52:e1–142. ©2010 David Stultz, MD NaturalNatural HistoryHistory ofof MitralMitral ValveValve diseasedisease (1991)(1991)

Blue = Mitral Stenosis; Purple = Mitral Regurgitation Solid = Medical Management; Dashed = Surgical Management ©2010 David Stultz, MD SurgicalSurgical ManagementManagement

 IndicatedIndicated forfor  ModerateModerate (NYHA(NYHA ClassClass 2)2) symptomssymptoms  PAPA pressurepressure >60mmHg>60mmHg  PCWPPCWP pressurepressure >25mmHg>25mmHg  PercutaneousPercutaneous balloonballoon valvotomyvalvotomy  FavoredFavored ifif echoecho showsshows  High leaflet mobility  Low calcification, thickening, and subvalvular thickening  Open/ClosedOpen/Closed SurgicalSurgical valvotomyvalvotomy  MitralMitral ValveValve replacementreplacement

Bonow RO, Carabello BA, Chatterjee K, de Leon AC Jr., Faxon DP, Freed MD, Gaasch WH, Lytle BW, Nishimura RA, O’Gara PT, O’Rourke RA, Otto CM, Shah PM, Shanewise JS. 2008 focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Valvular Heart Disease). J Am Coll Cardiol 2008;52:e1–142. ©2010 David Stultz, MD InoueInoue methodmethod ofof balloonballoon mitralmitral valvotomyvalvotomy ((transseptaltransseptal approach)approach)

Libby P, Bonow RO, Mann DL, Zipes DP. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, Saunders, 2007. ©2010 David Stultz, MD MeanMean pressurepressure gradientgradient acrossacross MitralMitral ValveValve PrePre-- andand PostPost-- BalloonBalloon ValvotomyValvotomy

Libby P, Bonow RO, Mann DL, Zipes DP. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, Saunders, 2007. ©2010 David Stultz, MD WhyWhy isis mitralmitral regurgitationregurgitation soso complicated?complicated?  VariableVariable etiologiesetiologies  VariableVariable symptomssymptoms  GenerallyGenerally slowslow onsetonset  SymptomsSymptoms oftenoften overlapoverlap withwith deconditioningdeconditioning andand agingaging  VariableVariable comorbitiescomorbities  CardiacCardiac  Role of coronary & myocardial disease  SystemicSystemic  GuidelinesGuidelines oftenoften basedbased onon specificspecific numericalnumerical cutoffscutoffs forfor variousvarious measurementsmeasurements ©2010 David Stultz, MD SymptomsSymptoms ofof MRMR

 TypicallyTypically developdevelop overover aa longerlonger timetime frameframe thanthan mitralmitral stenosisstenosis  ShortnessShortness ofof breathbreath  Weakness/fatigueWeakness/fatigue

 DevelopmentDevelopment ofof atrialatrial fibrillationfibrillation ©2010 David Stultz, MD PhysicalPhysical ExaminationExamination forfor MRMR

 SystolicSystolic murmurmurmur  HolosystolicHolosystolic  ConstantConstant intensityintensity  Blowing,Blowing, highhigh pitchpitch  LoudestLoudest atat apex,apex, radiatesradiates toto axillaaxilla

http://en.wikipedia.org/wiki/File:Phonocardiograms_from_normal_and_abnormal_heart_sounds.png http://depts.washington.edu/physdx/heart/tech.html ©2010 David Stultz, MD CausesCauses ofof ChronicChronic MRMR

 Inflammatory  Rheumatic heart disease  Systemic lupus erythematosus  Scleroderma  Degenerative  Myxomatous degeneration of mitral valve leaflets (Barlow click-murmur syndrome, prolapsing leaflet, mitral valve prolapse)  Marfan syndrome  Ehlers-Danlos syndrome  Pseudoxanthoma elasticum  Calcification of mitral valve annulus  Infective  Infective endocarditis affecting normal, abnormal, or prosthetic mitral valves  Structural  Ruptured chordae tendineae (spontaneous or secondary to myocardial infarction, trauma, mitral valve prolapse, endocarditis)  Rupture or dysfunction of papillary muscle (ischemia or myocardial infarction)  Dilation of mitral valve annulus and left ventricular cavity (congestive cardiomyopathies, aneurysmal dilation of the left )  Hypertrophic cardiomyopathy  Paravalvular prosthetic leak  Congenital  Mitral valve clefts or fenestrations  Parachute mitral valve abnormality in association with:  Endocardial cushion defects  Endocardial fibroelastosis  Transposition of the great arteries  Anomalous origin of the left coronary artery

Libby P, Bonow RO, Mann DL, Zipes DP. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, Saunders, 2007. ©2010 David Stultz, MD HowHow oftenoften shouldshould II getget anan echo?echo?  ModerateModerate toto SevereSevere MRMR (Asymptomatic)(Asymptomatic)  EveryEvery 66--1212 monthsmonths  ModerateModerate MRMR  NotNot specifiedspecified inin GuidelinesGuidelines oror appropriatenessappropriateness criteriacriteria  AsymptomaticAsymptomatic MildMild MRMR  NotNot routinelyroutinely recommendedrecommended  EchoEcho isis recommendedrecommended forfor changechange inin symptomssymptoms Bonow RO, Carabello BA, Chatterjee K, de Leon AC Jr., Faxon DP, Freed MD, Gaasch WH, Lytle BW, Nishimura RA, O’Gara PT, O’Rourke RA, Otto CM, Shah PM, Shanewise JS. 2008 focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Valvular Heart Disease). J Am Coll Cardiol 2008;52:e1–142.

Douglas PS, Khandheria B, Stainback RF, Weissman NJ. ACCF/ASE/ACEP/ASNC/SCAI/SCCT/SCMR, 2007 appropriateness criteria for transthoracic and transesophageal . J Am Coll Cardiol 2007. ©2010 David Stultz, MD

ManagingManaging ChronicChronic SevereSevere MRMR

Bonow RO, Carabello BA, Chatterjee K, de Leon AC Jr., Faxon DP, Freed MD, Gaasch WH, Lytle BW, Nishimura RA, O’Gara PT, O’Rourke RA, Otto CM, Shah PM, Shanewise JS. 2008 focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Valvular Heart Disease). J Am Coll Cardiol 2008;52:e1–142. ©2010 David Stultz, MD EchocardiographyEchocardiography

 PrimaryPrimary tooltool forfor assessingassessing severityseverity ofof MitralMitral regurgitationregurgitation ©2010 David Stultz, MD MildMild MitralMitral RegurgitationRegurgitation ©2010 David Stultz, MD ModerateModerate MitralMitral RegurgitationRegurgitation ©2010 David Stultz, MD ModerateModerate MRMR CWCW jetjet ©2010 David Stultz, MD PISAPISA –– ModerateModerate MRMR ©2010 David Stultz, MD SevereSevere MitralMitral RegurgitationRegurgitation ©2010 David Stultz, MD EtiologyEtiology ofof MitralMitral RegurgitationRegurgitation

 PrimaryPrimary  FlailFlail leafletleaflet  MitralMitral valvevalve prolapseprolapse  PerforationPerforation (endocarditis)(endocarditis)  ChordalChordal rupturerupture  SecondarySecondary  AnnularAnnular dilatationdilatation  IschemicIschemic mitralmitral regurgitationregurgitation  RemodelingRemodeling ofof papillarypapillary musclemuscle ©2010 David Stultz, MD SimplifiedSimplified MechanismsMechanisms ofof MitralMitral RegurgitationRegurgitation Normal

Prolapse

Flail leaflet

Restricted leaflet motion

Perforated leaflet

Annular dilatation ©2010 David Stultz, MD Carpentier Classification

Type I - normal leaflet length and motion but with either annular dilation or leaflet perforation

Type II MR is caused by leaflet prolapse or by papillary muscle rupture or elongation.

Type III MR is caused by restricted leaflet motion. Type IIIa - rheumatic disease with subvalvular involvement. Type IIIb – tethered and restricted leaflet motion due to ischemic or idiopathic cardiomyopathy with ventricular dilation.

Fedak PW, McCarthy PM, Bonow RO. Evolving concepts and technologies in mitral valve repair. Circulation. 2008 Feb 19;117(7):963- 74. ©2010 David Stultz, MD FlailFlail posteriorposterior leafletleaflet tiptip ©2010 David Stultz, MD IschemicIschemic MitralMitral RegurgitationRegurgitation ©2010 David Stultz, MD MitralMitral valvevalve leafletleaflet perforationperforation EndocarditisEndocarditis ©2010 David Stultz, MD DilatedDilated CardiomyopathyCardiomyopathy ((NonischemicNonischemic))

End Systole End Diastole Failure of coaptation ©2010 David Stultz, MD MitralMitral ValveValve ProlapseProlapse

 DefinedDefined asas billowingbillowing ofof thethe mitralmitral valvevalve leafletleaflet 2mm2mm beyondbeyond thethe annularannular planeplane inin thethe parasternalparasternal longlong axisaxis viewview  MyxomatousMyxomatous degenerationdegeneration inin youngeryounger patientspatients  FibroelasticFibroelastic tissuetissue deficiencydeficiency inin elderlyelderly  11--2.5%2.5% prevalenceprevalence  HeterogenousHeterogenous naturalnatural historyhistory  55--10%10% progressprogress toto severesevere mitralmitral regurgitationregurgitation

Libby P, Bonow RO, Mann DL, Zipes DP. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, Saunders, 2007. ©2010 David Stultz, MD MyxomatousMyxomatous mitralmitral valvevalve

Libby P, Bonow RO, Mann DL, Zipes DP. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, Saunders, 2007. ©2010 David Stultz, MD PhysicalPhysical ExamExam inin MVPMVP

 SystolicSystolic ClickClick  BestBest heardheard withwith diaphragmdiaphragm  OccursOccurs atat leastleast 140ms140ms afterafter S1S1  CausedCaused byby suddensudden tensingtensing ofof chordaechordae duringduring systolesystole  ManeuversManeuvers thatthat decreasedecrease LVLV volumevolume movemove clickclick closercloser toto S1S1  ManeuversManeuvers thatthat increaseincrease LVLV volumevolume movemove clickclick awayaway fromfrom S1S1 andand lowerlower intensityintensity

Libby P, Bonow RO, Mann DL, Zipes DP. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, Saunders, 2007. http://www.texasheart.org/education/cme/explore/events/eventdetail_5469.cfm ©2010 David Stultz, MD

Libby P, Bonow RO, Mann DL, Zipes DP. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, Saunders, 2007. ©2010 David Stultz, MD MitralMitral ValveValve ProlapseProlapse SyndromeSyndrome  ClusterCluster ofof symptomssymptoms  PalpitationsPalpitations  ChestChest painpain  TIATIA symptomssymptoms

 GuidelinesGuidelines basebase treatmenttreatment onon  CerebrovascularCerebrovascular eventevent  AtrialAtrial fibrillationfibrillation  SeveritySeverity ofof MitralMitral regurgitationregurgitation ©2010 David Stultz, MD MildMild MVPMVP

Diastole Systole ©2010 David Stultz, MD SevereSevere MVPMVP ©2010 David Stultz, MD AcuteAcute SevereSevere MitralMitral RegurgitationRegurgitation

 UsuallyUsually SignificantSignificant SymptomsSymptoms  ShortnessShortness ofof BreathBreath  HypotensionHypotension  SuddenSudden changechange inin valvularvalvular functionfunction  PerforationPerforation  PapillaryPapillary musclemuscle dysfunctiondysfunction  ChordalChordal rupturerupture ©2010 David Stultz, MD CausesCauses ofof AcuteAcute MRMR

 Mitral Annulus Disorders  Infective endocarditis (abscess formation)  Trauma (valvular heart surgery)  Paravalvular leak caused by suture interruption (surgical technical problems or infective endocarditis)  Mitral Leaflet Disorders  Infective endocarditis (perforation or interference with valve closure by vegetation)  Trauma (tear during percutaneous balloon mitral valvotomy or penetrating chest injury)  Tumors (atrial myxoma)  Myxomatous degeneration  Systemic lupus erythematosus (Libman-Sacks lesion)  Rupture of Chordae Tendineae  Idiopathic (e.g., spontaneous)  Myxomatous degeneration (mitral valve prolapse, Marfan syndrome, Ehlers-Danlos syndrome)  Infective endocarditis  Acute rheumatic fever  Trauma (percutaneous balloon valvotomy, blunt chest trauma)  Papillary Muscle Disorders  (causing dysfunction and rarely rupture)  Acute global left ventricular dysfunction Infiltrative diseases (amyloidosis, sarcoidosis)  Trauma  Primary Mitral Valve Prosthetic Disorders  Porcine cusp perforation (endocarditis)  Porcine cusp degeneration  Mechanical failure (strut fracture)  Immobilized disc or ball of the mechanical prosthesis

Libby P, Bonow RO, Mann DL, Zipes DP. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, Saunders, 2007. ©2010 David Stultz, MD DiagnosisDiagnosis ofof AcuteAcute SevereSevere MRMR

 AuscultationAuscultation maymay notnot bebe remarkableremarkable  EchocardiographyEchocardiography isis primaryprimary diagnosticdiagnostic modalitymodality

 MedicalMedical managementmanagement limitedlimited  NitroprussideNitroprusside forfor afterloadafterload reductionreduction  SurgicalSurgical managementmanagement usuallyusually indicatedindicated

Libby P, Bonow RO, Mann DL, Zipes DP. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, Saunders, 2007. ©2010 David Stultz, MD SurgicalSurgical RepairRepair

 RepairRepair favoredfavored overover valvevalve replacementreplacement

 NewNew endovascularendovascular techniquestechniques promisingpromising  EVERESTEVEREST 22 trialtrial forfor MitraClipMitraClip  OtherOther percutaneouspercutaneous methodsmethods ©2010 David Stultz, MD RepairRepair ofof PosteriorPosterior MVPMVP

Libby P, Bonow RO, Mann DL, Zipes DP. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, Saunders, 2007. ©2010 David Stultz, MD AlferiAlferi SurgicalSurgical RepairRepair

Fedak PW, McCarthy PM, Bonow RO. Evolving concepts and technologies in mitral valve repair. Circulation. 2008 Feb 19;117(7):963- 74. ©2010 David Stultz, MDCatheter-Based Mitral Valve Repair MitraClip® System

4 Investigational Device only in the US; Not available for sale in the US Endovascular Valve Edge-to-Edge Repair Study (EVEREST 2) Randomized Clinical Trial: Primary Safety and Efficacy Endpoints. Ted Feldman, Laura Mauri, Elyse Foster, Don Glower on behalf of the EVEREST 2 Investigators. ACC 2010 Annual Scientific Sessions, March 14, 2010, Atlanta, GA ©2010 David Stultz, MD EVEREST II RCT: Summary

 Safety & effectiveness endpoints met • Safety: MAE rate at 30 days – MitraClip device patients: 9.6% – MV surgery patients: 57%

• Effectiveness: Clinical Success Rate at 12 months – MitraClip device patients: 72% – MV Surgery patients: 88%

 Clinical benefit demonstrated for MitraClip System nda MV surgery patients through 12 months – Improved LV function – Improved NYHA Functional Class – Improved Quality of Life

 Surgery remains an option after the MitraClip procedure

27 Investigational Device only in the US; Not available for sale in the US

Endovascular Valve Edge-to-Edge Repair Study (EVEREST 2) Randomized Clinical Trial: Primary Safety and Efficacy Endpoints. Ted Feldman, Laura Mauri, Elyse Foster, Don Glower on behalf of the EVEREST 2 Investigators. ACC 2010 Annual Scientific Sessions, March 14, 2010, Atlanta, GA ©2010 David Stultz,OtherOther MD investigationalinvestigational percutaneouspercutaneous methodsmethods

Van Mieghem NM, Piazza N, Anderson RH, Tzikas A, Nieman K, De Laat LE, McGhie JS, Geleijnse ML, Feldman T, Serruys PW, de Jaegere PP. Anatomy of the mitral valvular complex and its implications for transcatheter interventions for mitral regurgitation. J Am Coll Cardiol. 2010 Aug 17;56(8):617-26. ©2010 David Stultz, MD CoronaryCoronary SinusSinus DevicesDevices

Carillon (Cardiac Dimensions, Inc., Kirkland, Washington)

Edwards MONARC (Edwards Lifesciences, Irvine, California)

Percutaneous Transvenous Mitral Annuloplasty (PTMA) (Viacor, Inc., Wilmington, Massachusetts)

Van Mieghem NM, Piazza N, Anderson RH, Tzikas A, Nieman K, De Laat LE, McGhie JS, Geleijnse ML, Feldman T, Serruys PW, de Jaegere PP. Anatomy of the mitral valvular complex and its implications for transcatheter interventions for mitral regurgitation. J Am Coll Cardiol. 2010 Aug 17;56(8):617-26. ©2010 David Stultz, MD

Mitralign – retrograde catheter in LV anchors to AV junction and cinches together Quantumcor – thermal energy at AV junction to shrink orifice Ample PS3 – Left atrial T bar anchored by septal occluder/coronary sinus iCoapsys – Transventricular bridge to change LV geometry

Van Mieghem NM, Piazza N, Anderson RH, Tzikas A, Nieman K, De Laat LE, McGhie JS, Geleijnse ML, Feldman T, Serruys PW, de Jaegere PP. Anatomy of the mitral valvular complex and its implications for transcatheter interventions for mitral regurgitation. J Am Coll Cardiol. 2010 Aug 17;56(8):617-26. ©2010 David Stultz, MD ReferencesReferences  Carabello BA. Modern management of mitral stenosis. Circulation. 2005 Jul 19;112(3):432-7.  Bonow RO, Carabello BA, Chatterjee K, de Leon AC Jr., Faxon DP, Freed MD, Gaasch WH, Lytle BW, Nishimura RA, O’Gara PT, O’Rourke RA, Otto CM, Shah PM, Shanewise JS. 2008 focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Valvular Heart Disease). J Am Coll Cardiol 2008;52:e1–142.  Douglas PS, Khandheria B, Stainback RF, Weissman NJ. ACCF/ASE/ACEP/ASNC/SCAI/SCCT/SCMR, 2007 appropriateness criteria for transthoracic and transesophageal echocardiography. J Am Coll Cardiol 2007.  Fedak PW, McCarthy PM, Bonow RO. Evolving concepts and technologies in mitral valve repair. Circulation. 2008 Feb 19;117(7):963-74.  Libby P, Bonow RO, Mann DL, Zipes DP. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, Saunders, 2007.  Van Mieghem NM, Piazza N, Anderson RH, Tzikas A, Nieman K, De Laat LE, McGhie JS, Geleijnse ML, Feldman T, Serruys PW, de Jaegere PP. Anatomy of the mitral valvular complex and its implications for transcatheter interventions for mitral regurgitation. J Am Coll Cardiol. 2010 Aug 17;56(8):617-26.