ATP2B4 Antibody Cat. No.: 57-793

ATP2B4 Antibody

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human

This ATP2B4 antibody is generated from rabbits immunized with a KLH conjugated IMMUNOGEN: synthetic peptide between 1174-1202 amino acids from the C-terminal region of human ATP2B4.

TESTED APPLICATIONS: WB

APPLICATIONS: For WB starting dilution is: 1:1000

PREDICTED MOLECULAR 138 kDa WEIGHT:

Properties

This antibody is purified through a protein A column, followed by peptide affinity PURIFICATION: purification.

CLONALITY: Polyclonal

ISOTYPE: Rabbit Ig

CONJUGATE: Unconjugated

September 26, 2021 1 https://www.prosci-inc.com/atp2b4-antibody-57-793.html PHYSICAL STATE: Liquid

BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.

CONCENTRATION: batch dependent

Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Additional Info

OFFICIAL SYMBOL: ATP2B4

Plasma membrane calcium-transporting ATPase 4, PMCA4, Matrix-remodeling-associated ALTERNATE NAMES: protein 1, Plasma membrane calcium ATPase isoform 4, Plasma membrane calcium pump isoform 4, ATP2B4, ATP2B2, MXRA1

ACCESSION NO.: P23634

PROTEIN GI NO.: 14286105

GENE ID: 493

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

The protein encoded by this belongs to the family of P-type primary ion transport characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate and the diversity of these enzymes is further increased by BACKGROUND: of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq].

REFERENCES: 1) Holton, M., et al. Cardiovasc. Res. 87(3):440-448(2010)

2) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

3) Juranic, N., et al. J. Biol. Chem. 285(6):4015-4024(2010)

4) Ehret, G.B., et al. Eur. J. Hum. Genet. 17(12):1650-1657(2009)

ANTIBODIES FOR RESEARCH USE ONLY.

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