Leukaemia Section

Total Page：16

File Type：pdf, Size：1020Kb

Atlas of Genetics and Cytogenetics in Oncology and Haematology OPEN ACCESS JOURNAL AT INIST-CNRS Leukaemia Section Short Communication t(3;11)(q29;p15) Li-Ting Chen, Sai-Juan Chen Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China (L-TC, S-JC) Published in Atlas Database: February 2009 Online updated version: http://AtlasGeneticsOncology.org/Anomalies/t0311q29p15ID1508.html DOI: 10.4267/2042/44667 This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence. © 2010 Atlas of Genetics and Cytogenetics in Oncology and Haematology Identity Complex translocation t(3;11)(q29q13;p15)del(3)(q29). A: Red arrow indicates der(3); green arrow indicates der(11). The chromosomes displaying only red color or green color (yellow arrows) are normal chromosomes 11 and 3, respectively. Insert: Representative partial karyotype showing t(3;11). Clinics and pathology Phenotype/cell stem origin Only one case available; BM showed 82.5% blast cells Disease mostly with myeloid features. Immuno-phenotype: Bi-phenotypic acute T-lymphoid/myeloid leukemia CD34+ cells count 35.6%, CD13+ 25.9%, CD33+ 85.4%, MPO+ 20.6% and CD3+ 65.9%, CD7+ 96.5%. Atlas Genet Cytogenet Oncol Haematol. 2010; 14(1) 70 t(3;11)(q29;p15) Chen L-T, Chen S-J Clinics Additional anomalies Only one case available; the patient was a 42-year-old +21 female at diagnosis. After the chemotherapy with vincristine, cytarabine and mitoxantrone, she achieved Genes involved and proteins complete remission (CR), but relapsed after 4 months, and died from intracranial hemorrhage at the 22 nd NUP98 months. Location Prognosis 11p15.5 The prognostic implication of t(3;11)(q29q13;p15) Protein del(3)(q29) remains to be defined. Nucleoporin 98, a 98 kDa component of the nuclear pore complex, which mediates nucleo-cytoplasmic Cytogenetics transport of protein and RNA. IQCG (IQ motif containing G) Location 3q29 Protein 443 amino acids. Result of the chromosomal anomaly Hybrid gene Description 5' NUP98 - 3' IQCG; Molecular analysis showed that exon 13 of NUP98 is fused in-frame to exon 10 of IQCG. Fusion protein Description It fuses the GLFG repeat domains of NUP98 to one coiled-coil domain and IQ motif of IQCG. Expression / Localisation Nuclear localization. References Pan Q, Zhu YJ, Gu BW, Cai X, Bai XT, Yun HY, Zhu J, Chen B, Weng L, Chen Z, Xue YQ, Chen SJ. A new fusion gene NUP98-IQCG identified in an acute T-lymphoid/myeloid leukemia with a t(3;11)(q29q13;p15)del(3)(q29) translocation. Oncogene. 2008 May 29;27(24):3414-23 This article should be referenced as such: Chen L-T, Chen S-J. t(3;11)(q29;p15). Atlas Genet Cytogenet Oncol Haematol. 2010; 14(1):70-71. B: Schematic diagram of t(3;11)(q29q13;p15)del(3)(q29). Atlas Genet Cytogenet Oncol Haematol. 2010; 14(1) 71 .

Copy Link

Recommended publications

Encephalomyelitis Ameliorates Experimental Autoimmune And
The Journal of Immunology Vibsanin B Preferentially Targets HSP90b, Inhibits Interstitial Leukocyte Migration, and Ameliorates Experimental Autoimmune Encephalomyelitis Bai-Xin Ye,*,1 Xu Deng,†,1 Li-Dong Shao,† Ying Lu,* Run Xiao,* Yi-Jie Liu,* Yi Jin,* Yin-Yin Xie,* Yan Zhao,* Liu-Fei Luo,* Shun Ma,‡ Ming Gao,x Lian-Ru Zhang,‡ Juan He,† Wei-Na Zhang,* Yi Chen,* Cheng-Feng Xia,† Min Deng,{ Ting-Xi Liu,*,{ Qin-Shi Zhao,† Sai-Juan Chen,* and Zhu Chen* Interstitial leukocyte migration plays a critical role in inflammation and offers a therapeutic target for treating inflammation- associated diseases such as multiple sclerosis. Identifying small molecules to inhibit undesired leukocyte migration provides promise for the treatment of these disorders. In this study, we identified vibsanin B, a novel macrocyclic diterpenoid isolated from Viburnum odoratissimum Ker-Gawl, that inhibited zebrafish interstitial leukocyte migration using a transgenic zebrafish line (TG:zlyz– enhanced GFP). We found that vibsanin B preferentially binds to heat shock protein (HSP)90b. At the molecular level, inacti- vation of HSP90 can mimic vibsanin B’s effect of inhibiting interstitial leukocyte migration. Furthermore, we demonstrated that vibsanin B ameliorates experimental autoimmune encephalomyelitis in mice with pathological manifestation of decreased leuko- cyte infiltration into their CNS. In summary, vibsanin B is a novel lead compound that preferentially targets HSP90b and inhibits interstitial leukocyte migration, offering a promising drug lead for treating inflammation-associated diseases. The Journal of Immunology, 2015, 194: 4489–4497. eukocyte trafficking is a multistep process consisting of moattractant signals, plays an important role in immune cell de- transendothelial and interstitial migration of leukocytes, velopment, immunosurveillance, and effector functions.
[Show full text]
Acupuncture in China
Acupuncture in China A Suggested Curriculum for a 4th-Year Clinical Rotation April 14, 2011 Ben Mervak, Alison Kalinowski, and Malani Gupta Table of Contents A LETTER OF INTRODUCTION ................................................................................................ 2 SUGGESTED LEARNING OBJECTIVES .......................................................................................... 3 INTRODUCTION TO ACUPUNCTURE AND RELATED THERAPIES .......................................................... 4 PATIENT DEMOGRAPHICS ..................................................................................................... 7 SAMPLE AM CLINIC PATIENT LOG ........................................................................................ 8 SAMPLE AM CLINIC PROCEDURE LOG ................................................................................... 9 CASE REPORT .................................................................................................................. 10 1. PLACEMENT OF SCALP NEEDLES ....................................................................................... 11 2. PLACEMENT OF UPPER EXTREMITY NEEDLES ......................................................................... 11 3. PLACEMENT OF ABDOMINAL NEEDLES ................................................................................ 12 4. PLACEMENT OF LOWER EXTREMITY NEEDLES........................................................................ 13 RECOMMENDED REQUIREMENTS FOR FUTURE ROTATORS .............................................................
[Show full text]
Orthotopic Liver Transplantation for Primary Intrahepatic Adenosquamous Carcinoma Using a Marginal Graft: the First Case Rrport
Orthotopic Liver Transplantation for Primary Intrahepatic Adenosquamous Carcinoma Using A Marginal Graft: the First Case rRport Peng Chen Shanghai Jiao Tong University Medical School Aliated Ruijin Hospital Di Ma Shanghai Jiao Tong University Medical School Aliated Ruijin Hospital Ruokun Li Shanghai Jiao Tong University Medical School Aliated Ruijin Hospital Xiaoqun Yang Shanghai Jiao Tong University Medical School Aliated Ruijin Hospital Hui Tong Shanghai Jiao Tong University Medical School Aliated Ruijin Hospital Debin Qi Shanghai Jiao Tong University Medical School Aliated Ruijin Hospital Tao Li ( [email protected] ) Shanghai Jiao Tong University Medical School Aliated Ruijin Hospital https://orcid.org/0000-0003- 4035-0729 Case report Keywords: case report, cancer/malignancy/neoplasia, primary adenosquamous carcinoma, cholangiocarcinoma, liver transplantation/hepatology Posted Date: December 2nd, 2020 DOI: https://doi.org/10.21203/rs.3.rs-117738/v1 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Page 1/17 Abstract Background. Primary intrahepatic adenosquamous carcinoma (iASC) is a very rare subtype of cholangiocarcinoma (CCA), with a worse prognosis than adenocarcinoma. Hepatectomy is still the rst choice for iASC, and liver transplantation (LT) for iASC has not been previously reported. Case presentation The young male patient with an unresectable primary iASC underwent a LT using a marginal fatty liver graft. The overall survival of this patient was 16 months, with a recurrence-free survival of 8 months. The patient had a good quality of life with normal liver function until 3 months before death. Conclusions. This is the rst case report of LT as treatment of unresectable iASC using a marginal graft.
[Show full text]
Reply to Kesici Et Al. and Zeng Et Al.: Blocking the Virus and Reducing The
LETTER REPLY TO KESICI ET AL. AND ZENG ET AL.: Blocking the virus and reducing the inflammatory LETTER damage in COVID-19 Kai Duana,b,1, Bende Liuc,1, Cesheng Lid,1, Huajun Zhange,1, Ting Yuf,1, Jieming Qug,h,i,1, Min Zhoug,h,i,1, Li Chenj,1, Zhu Chenk,2, Xinxin Zhangl,2, and Xiaoming Yanga,b,2 We appreciate the constructive comments from Kesici macrophage infiltration and a further worsening of et al. (1) and Zeng et al. (2), which mainly focus on the lung injury. Therefore, the key point of CP therapy is key points about the optimal procedure of convales- to neutralize the virus and to interrupt the vicious cycle cent plasma (CP) transfusion in severe coronavirus dis- of excessive activation of the immune response in se- ease 2019 (COVID-19) therapy and about how to vere patients. In our study, 200 mL CP containing neu- improve the effectiveness. tralized antibody above 1:640 rapidly cleared the First of all, this study was a pilot trial and the aim viremia and achieved clinical improvement. Consider- was to investigate the safety of CP transfusion, which ing the accessibility of plasma donors, using CP as was defined as the primary endpoint (3). We neverthe- replacement fluid for the therapeutic plasma ex- less also explored the possible therapeutic benefits of change may be not feasible. CP by examining its effectiveness in neutralizing the Third, the optimal treatment time and dose of CP severe acute respiratory syndrome coronavirus 2 need to be determined by the knowledge on viral (SARS-CoV-2) and in ameliorating clinical symptoms proliferative kinetics.
[Show full text]
Confidential: for Review Only Hydroxychloroquine in Patients Mainly with Mild to Moderate COVID–19: an Open–Label, Randomized, Controlled Trial
BMJ Confidential: For Review Only Hydroxychloroquine in patients mainly with mild to moderate COVID–19: an open–label, randomized, controlled trial Journal: BMJ Manuscript ID BMJ-2020-056844.R1 Article Type: Research BMJ Journal: BMJ Date Submitted by the 22-Apr-2020 Author: Complete List of Authors: Tang, Wei; Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Cao, Zhujun; Department of Infectious Disease, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Han, Mingfeng; Department of Respiratory Medicine. No.2 people's hospital of Fuyang city, Fuyang, Anhui, China Wang, Zhengyan; Department of Respiratory Medicine, Suizhou Hospital, Hubei University of Medicine, Suizhou, Hubei, China Chen, Junwen; Xiangyang No.1 People’s Hospital Affiliated hospital of Hubei University of Medicine Sun, Wenjin; Department of Infectious Diseases, Central Hospital of Ezhou, Ezhou, Hubei, China Wu, Yaojie; Department of Cardiovascular Medicine, Yunmeng people's hospital, Xiaogan, Hubei, China Xiao, Wei; The First People’s Hospital of Jingzhou. Liu, Shengyong; Department of Infectious Diseases, Xiaogan hospital affiliated to Wuhan university of science and technology, Xiaogan, Hubei, China Chen, Erzhen; Department of Emergency Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Chen, Wei; Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine,
[Show full text]
Famous Hospitals in Shanghai City
Famous Hospitals in Shanghai City Franco Naccarella Medical service system and pertinent bureau • There are four medical service systems in Shanghai. • They are Fu Dan University, Shanghai Jiao Tong University, Tong Jing University, Shanghai Traditional Chinese Medical School • Shanghai Bureau of health make the rule of hearth care and supervise all the hospitals attached to their university. Top Ten Hospital Fudan University • Zhongshan Hospital • Huashan Hospital Shanghai Jiao Tong University • First People’s Hospital • Sixth People’s Hospital • Renji Hospital • Ruijin Hospital • Xinhua Hospital • Nineth People’s Hospital Second Military Medical University • Changhai Hospital • Changzheng Hospital Zhongshan hospital Zhongshan hospital • Zhongshan Hospital was founded in 1936 in commemoration of the late Dr. Sun Yat- sen. It is a leading hospital in China and was awarded "The Best 100 Hospitals" in 1999 • The discipline of Zhongshan Hospital is Prudent, Practicality, Unity and Offering Zhongshan hospital www.zs-hospital.sh.cn • Cardiology, Hepatology,Nephrology and Respiratory diseases are their leading subject • Cardiology research institute is well known in the world. They performed the first cardiac catheter examination in China Zhongshan hospital • Cardiology department is the largest in Shanghai area. They have three catheter room, non-invasive cardiac exam center including treadmill exercise test, tilt table test, holter monitor, ABPM and advanced Echo center. • EP center have sophisticated EP console. They own CARTO-XP 3 dimension electroanatomy mapping equipment Zhongshan hospital • Their emergency PCI number is the largest in Shanghai area, about 400 cases for one year, and more than 1000 cases of selective PCI cases every year • The cardiolog department is also well known for myocardiopathy and myocarditis research • They are number of national qualified clinical medicine trial base and national EP training base Zhongshan hospital • The chief of cardiolgy is prof.
[Show full text]
Radiological Appearances of Anastomotic Leakage After Radical Gastrectomy
medRxiv preprint doi: https://doi.org/10.1101/2020.04.25.20080093; this version posted July 29, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license . Original article Radiological appearances of Anastomotic Leakage after Radical Gastrectomy Sah BK, Zhang Y, Zhang H, Li J, Liu Wentao, Yan Chao, Li C, Yan M, Zhu ZG Running title: Radiological appearances of anastomotic leakage 1 NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice. medRxiv preprint doi: https://doi.org/10.1101/2020.04.25.20080093; this version posted July 29, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license . Authors *Birendra Kumar Sah, MD/Ph D Department of General Surgery, Gastrointestinal Surgery Unit Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Gastric Neoplasms Shanghai Institute of Digestive Surgery Shanghai, China. Postal add: 197 Ruijin Er Road, Shanghai-200025, China Contact no. : Ph: 0086-21-64370045 ext 671302 Email: [email protected] Zhang Yang (Co-first author) Department of Radiology, Zhejiang Provincial People' Hospital, People' Hospital of Hangzhou Medical College, Hangzhou, China Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
[Show full text]
Protocol for a Randomized Controlled Trial of Perioperative S-1 Plus
1684 Study Protocol Page 1 of 7 Protocol for a randomized controlled trial of perioperative S-1 plus oxaliplatin combined with apatinib and camrelizumab in patients with resectable, locally advanced gastric or gastroesophageal junction adenocarcinoma Yanan Zheng1, Zhenqiang Wang1, Chao Yan1, Min Yan1, Zhiguo Hou2, Rongrong Zheng2, Zhenggang Zhu1, Chen Li1 1Department of Gastrointestinal Surgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Digestive Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai, China; 2Jiangsu Hengrui Pharmaceuticals Co., Ltd., Shanghai, China Correspondence to: Zhenggang Zhu; Chen Li. Department of Gastrointestinal Surgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Digestive Surgery, Shanghai Key Laboratory of Gastric Neoplasms, No. 197 Ruijin ER Road, Huangpu District, Shanghai 200025, China. Email: [email protected]; [email protected]. Background: Perioperative therapy can improve the low survival benefit of surgery alone for locally advanced gastric cancer. The introduction of immunotherapy and its combination with chemotherapy and/ or targeted therapy has created more opportunities for optimal treatment. The aim of the present study was to compare the efficacy and safety of S-1 plus oxaliplatin (SOX) combined with apatinib (SOXA) or SOX combined with apatinib and camrelizumab (SOXAP) versus SOX as the perioperative therapy for resectable, locally advanced gastric or gastroesophageal junction (GEJ) adenocarcinoma. Methods: The study was a multicenter, randomized, open-label, parallel-controlled trial conducted in China. Eligible participants were randomized to the SOX, SOXA, and SOXAP groups. Patients received three pre-operative and three postoperative 3-week cycles of SOX or SOXA or SOXAP, followed by apatinib (SOXA group) or apatinib combined with camrelizumab (SOXAP group) for 3 cycles, which could be continued at the investigator's choice.
[Show full text]
BMJ Open Is Committed to Open Peer Review. As Part of This Commitment We Make the Peer Review History of Every Article We Publish Publicly Available
BMJ Open: first published as 10.1136/bmjopen-2019-031512 on 12 February 2020. Downloaded from BMJ Open is committed to open peer review. As part of this commitment we make the peer review history of every article we publish publicly available. When an article is published we post the peer reviewers’ comments and the authors’ responses online. We also post the versions of the paper that were used during peer review. These are the versions that the peer review comments apply to. The versions of the paper that follow are the versions that were submitted during the peer review process. They are not the versions of record or the final published versions. They should not be cited or distributed as the published version of this manuscript. BMJ Open is an open access journal and the full, final, typeset and author-corrected version of record of the manuscript is available on our site with no access controls, subscription charges or pay-per-view fees (http://bmjopen.bmj.com). If you have any questions on BMJ Open’s open peer review process please email [email protected] http://bmjopen.bmj.com/ on September 28, 2021 by guest. Protected copyright. BMJ Open BMJ Open: first published as 10.1136/bmjopen-2019-031512 on 12 February 2020. Downloaded from Relatively frequent rheumatic manifestations and autoantibodies in infective endocarditis: differentiating infective endocarditis from autoimmune disease is needed ForJournal: peerBMJ Open review only Manuscript ID bmjopen-2019-031512 Article Type: Research Date Submitted by the 18-May-2019 Author: Complete List of Authors: Zhou, Zhuochao; Shanghai Jiao Tong University School of Medicine, ; Ye, Junna Teng, Jialin Liu, Honglei Cheng, Xiaobing Sun, Yue Su, Yutong Chi, Huihui Wang, Fan Yang, Chengde; Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital Jin, Wei http://bmjopen.bmj.com/ Infective endocarditis, Rheumatic manifestation, ANCA, Antiphospholipid Keywords: antibody on September 28, 2021 by guest.
[Show full text]
Effectiveness of Convalescent Plasma Therapy in Severe COVID-19 Patients
Effectiveness of convalescent plasma therapy in severe COVID-19 patients Kai Duana,b,1, Bende Liuc,1, Cesheng Lid,1, Huajun Zhange,1, Ting Yuf,1, Jieming Qug,h,i,1, Min Zhoug,h,i,1, Li Chenj,1, Shengli Mengb, Yong Hud, Cheng Penge, Mingchao Yuank, Jinyan Huangl, Zejun Wangb, Jianhong Yud, Xiaoxiao Gaoe, Dan Wangk, Xiaoqi Yum,LiLib, Jiayou Zhangb, Xiao Wud, Bei Lie, Yanping Xug,h,i, Wei Chenb, Yan Pengd, Yeqin Hub, Lianzhen Lind, Xuefei Liug,h,i, Shihe Huangb, Zhijun Zhoud, Lianghao Zhangb, Yue Wangd, Zhi Zhangb, Kun Dengd, Zhiwu Xiab, Qin Gongd, Wei Zhangd, Xiaobei Zhengd, Ying Liud, Huichuan Yanga, Dongbo Zhoua, Ding Yua, Jifeng Houn, Zhengli Shie, Saijuan Chenl, Zhu Chenl,2, Xinxin Zhangm,2, and Xiaoming Yanga,b,2 aChina National Biotec Group Company Limited, 100029 Beijing, China; bNational Engineering Technology Research Center for Combined Vaccines, Wuhan Institute of Biological Products Co. Ltd., 430207 Wuhan, China; cFirst People’s Hospital of Jiangxia District, 430200 Wuhan, China; dSinopharm Wuhan Plasma-derived Biotherapies Co., Ltd, 430207 Wuhan, China; eKey Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071 Wuhan, China; fWuHan Jinyintan Hospital, 430023 Wuhan, China; gDepartment of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China; hNational Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai,
[Show full text]
Habenula Deep Brain Stimulation for Intractable Schizophrenia: a Pilot Study
NEUROSURGICAL FOCUS Neurosurg Focus 49 (1):E9, 2020 Habenula deep brain stimulation for intractable schizophrenia: a pilot study Yuhan Wang, MS,1 Chencheng Zhang, MD, PhD,1 Yingying Zhang, MSc,1 Hengfen Gong, MD,2 Jun Li, PhD,1 Haiyan Jin, MD,3 Dianyou Li, MD, PhD,1 Dengtang Liu, MD, PhD,4 and Bomin Sun, MD, PhD1 1Department of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine; 2Department of Psychiatry, Pudong Mental Health Center, Shanghai; 3Department of Psychiatry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine; and 4First-episode Schizophrenia and Early Psychosis Program, Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China Schizophrenia is a psychiatric disorder associated with significant morbidity and mortality. Although antipsychotic medications and electroconvulsive therapy can be used to manage the clinical symptoms of schizophrenia, a substantial portion (10%–30%) of patients do not clinically respond to these treatments or cannot tolerate the side effects. Recently, deep brain stimulation (DBS) has emerged as a promising safe and effective therapeutic intervention for various psychi- atric disorders. Here, the authors explore the utility of DBS of the habenula (HB) in the clinical management of 2 young adult male patients with severe, chronic, and treatment-resistant schizophrenia. After HB DBS surgery, both patients experienced improvements in clinical symptoms during the first 6 months of treatment. However, only 1 patient retained the clinical benefits and reached a favorable outcome at 12-month follow-up. The symptoms of the other patient sub- sequently worsened and became so profound that he needed to be hospitalized at 10-month follow-up and withdrawn from further study participation.
[Show full text]
Epidemiology, Species Distribution, and Outcome of Nosocomial Candida Spp
Epidemiology, species distribution, and outcome of nosocomial Candida spp. bloodstream infection in Shanghai — An 11-year retrospective analysis in a tertiary care hospital Yanjun Zheng Shanghai Jiao Tong University Medical School Aliated Ruijin Hospital Ting Xie Suining Central Hospital Lin Wu Shanghai Jiao Tong University Medical School Aliated Ruijin Hospital Xiaoying Liu Shanghai Jiao Tong University Medical School Aliated Ruijin Hospital Ling Zhu Shanghai Jiao Tong University Medical School Aliated Ruijin Hospital Ying Chen Shanghai Jiao Tong University Medical School Aliated Ruijin Hospital Enqiang Mao Shanghai Jiao Tong University Medical School Aliated Ruijin Hospital Lizhong Han Shanghai Jiao Tong University Medical School Aliated Ruijin Hospital Erzhen Chen Shanghai Jiao Tong University Medical School Aliated Ruijin Hospital Zhitao Yang ( [email protected] ) Ruijin Hospital https://orcid.org/0000-0002-6289-6493 Research Keywords: Candida spp, Bloodstream infection, Epidemiology, Species distribution, Antifungal therapy, Early treatment. Posted Date: March 15th, 2021 DOI: https://doi.org/10.21203/rs.3.rs-212048/v2 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Page 1/12 Abstract Background The incidence of Candida bloodstream infections (BSIs), has increased over time. In this study, we aimed to describe the current epidemiology of Candida BSI in a large tertiary care hospital in Shanghai and to determine the risk factors of 28-day mortality and the impact of antifungal therapy on clinical outcomes. Methods All consecutive adult inpatients with Candida BSI at Ruijin Hospital between January 1, 2008 and December 31, 2018 were enrolled. Underlying diseases, clinical severity, species distribution, antifungal therapy, and their impact on the outcomes were analyzed.
[Show full text]