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E-Newsletter October 2009 Center for Clinical and Translational Science e-Newsletter Center News New Certificate Program in Clinical and Translational Science Graduates First Class By Angela Slattery In September 2008, a new Certificate Program in Clinical and Translational Science began at Rockefeller University. Eighteen students from across campus participated in the inaugural class. In June 2009, all of the program’s students graduated and received a Certificate in Clinical and Translational Science from the university. The Certificate Program, which is sponsored by the Center for 2009 Inaugural Certificate in Clinical and Translational Science Class Clinical and Translational Science or his own hypothetical human subjects The protocols that were submitted (CCTS), was developed in collaboration protocol, including an informed consent in fulfillment of the requirement of with students and postdoctoral fellows form. To further familiarize the students the course were of exceptionally high to provide trainees with an introduction with the protocol review process, the caliber and offered insights into the to the principles and practices of clinical students then functioned as a mock IRB, clinical research interests of the talented and translational research. reviewing each of the protocols and group of investigators who enrolled in The Certificate Program is a one year offering suggestions to insure the optimal the program. Dr. Barry Coller, director program that consists of two courses. design and the greatest protection of the of the Certificate Program stated, Each student was required to create her human subjects that would participate. (continued on page 2) CCTS and Clinical Directors Network Successfully Complete First Collaborative Project By Angela Slattery In the fall of 2008, through the history phenotyping system. The goal 3) identifing patients whose laboratory Advisory Committee on Community of this initial project was to validate data and bleeding symptoms are Engagement and Recruitment (ACCER), the instrument. The eventual goal is discordant for future gene-gene and gene Clinical Scholar Dr. Andreas Mauer to provide the system to all authorized environment studies, and 4) assessing the was introduced to Dr. Jonathan Tobin, investigators with Internet access so that medically optimal and most cost-effective President and CEO of the Clinical they can have the opportunity to collect way of deciding whether to order an Directors Network (CDN). CDN is a bleeding history data in a standardized extensive laboratory evaluation. not-for-profit network that supports way and store the information in a single, Dr. Mauer obtained approval to enroll community-based health centers, uniform database. This database would 500 normal healthy participants in this including their patients, practitioners, aggregate deindentified data obtained by study from the Institutional Review and other affiliated organizations. many different investigators and would Board (IRB) and Advisory Committee Community health centers work with be freely accessible to investigators for Clinical and Translational Science CDN to assist with projects and facilitate worldwide. Potential applications of the (ACCTS). CDN was an ideal partner community engagement. system include: 1) improving diagnosis for this project because it could assist in of bleeding disorders, 2) identifing the Dr. Mauer and his mentor, Dr. Barry recruiting participants from community fewest number of questions needed to Coller, were interested in developing settings and their participation would exclude the presence of a significant and validating a Web-based bleeding broaden the diversity of the population bleeding disorder with high probability, (continued on page 2) 1 New Certificate Program in Clinical and Translational Science Graduates First Class (continued from page 1) “I am extremely impressed with the University and to demonstrate scientific/ scores for the Certificate in Clinical scientific and medical sophistication technical methods that are currently and Translational Science program as a of the projects and the techniques employed to address critical problems whole, 100% of the responders stated proposed; we are continuing to assess in human biology. Another purpose they would recommend the program whether some of these protocols might for the course was to familiarize the to their peers and felt that the program be performed in our hospital. This is an students with the Rockefeller University should continue to be offered to the exciting possibility for us.” personnel available to aid them in Rockefeller community. One interesting applying these cutting edge technologies. indication of the impact of the program The first course, Introduction to Clinical The final project for the course had the is that two of the students decided to and Translational Science, was offered students return to the protocols they had alter their career paths and apply for in fall 2008. It was twelve weeks long developed in the Introduction to Clinical admission to medical school. and consisted of two 90-minute lectures and Translational Science course and per week. The first lecture of each week In August of this year, Dr. Coller enhance the protocols by adding new described an important element in reviewed the course materials, student techniques such as bioimaging, high clinical and translational science (e.g., projects, and evaluations for the throughput screening, or gene targeting biostatistical considerations, human Certificate in Clinical and Translational that would augment the research design subjects protection, study design, etc.). Science Program with Dean Sid and facilitate their ability to test their The second lecture of each week was a Strickland and Assistant Dean Emily hypotheses. scientific presentation by a Rockefeller Harms. Based on the rigor of the University investigator explaining her Both courses received high evaluation courses, the quality of instruction, and or his research, emphasizing the element marks by the students, with 100% of the level of participation required, the taught at the beginning of the week. the students reporting that they would Dean’s Office decided that both courses recommend the courses to others, will now be offered for credit. CCTS is The second course in the program, nearly 75% of the students stating planning to offer the Certificate Program Introduction to Scientific Techniques the course changed their views about in alternate academic years based on in Clinical and Translational Science, clinical and translational research, and the assessment of likely enrollment and began in March 2009. Led by Drs. Sarah approximately 67% of the students faculty availability. The next Certificate Schlesinger and James Krueger, the goal stating that the course made them more Program is scheduled to begin in the fall of this course was to introduce students likely to conduct clinical or translational of 2010. to core resources available at Rockefeller research. In terms of the evaluation CCTS and Clinical Directors Network Successfully Complete First Collaborative Project (continued from page 1) studied. Drs. Coller and Mauer visited and interviewing patients, as well as on Thrombosis and Hemostasis meeting the Jersey City site together, met with educating the staff at the sites about the in Boston. Dr. Tobin, Dr. Mauer, and Dr. the staff, and learned from them about project. The time from study approval to Coller are working together on future the bleeding (hemostasis) problems study completion was approximately 10 collaborations. Dr. Mauer stated that, they face in their practice. Dr. Coller months; the Clinical Research Support “Dr. Tobin has been extremely helpful provided a lecture on hemostasis for Office (CRSO) recruitment program, with so many aspects of this project. I primary care physicians and described with the outstanding assistance of the look forward to future collaborations the goals of the project. Ultimately, CDN staff, made this accomplishment with Dr. Tobin and CDN.” from the 500 total participants in the possible. study, 365 were seen at Rockefeller In addition to CDN’s role in assisting University Hospital, 75 were seen at If you would like to contact Dr. Tobin to with participant recruitment, the Metropolitan Health Center in Jersey discuss whether your project may benefit from City, NJ and 60 were seen at Newark project benefited enormously from Dr. collaborating with CDN, you can contact him Community Health Center in Newark, Tobin’s expertise in study design and at [email protected] or call 212-382- NJ. Dr. Mauer oversaw the project and statistical approaches. Data from the 0699 ext. 234. Dr. Chamanara Khalida from CDN study were presented by Dr. Mauer in played an important role in recruiting July 2009 at the International Society 2 Clinical Scholars Program Graduates First Class of Master’s Degree in Clinical and Translational Research By Angela Slattery and Jennifer Spada In June of this year, the Clinical Scholars program had four graduates who were the first to receive the new Master’s Degree in Clinical and Translational Research. The KL2 Clinical Scholars program, which is supported in part by the Rockefeller University Clinical and Translational Science Award (CTSA), is a training experience designed to prepare physician-scientists and select doctoral level PhD investigators for independent careers in clinical and patient-oriented translational research. Dr. Marina Caskey, Dr. Edgar Charles, Left to right: Dr. Barry Coller,
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