DOCSLIB.ORG

Perfume Composition Containing a Derivative of Hydroxy Citronellal

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Perfume Composition Containing a Derivative of Hydroxy Citronellal Europaisches Patentamt J European Patent Office © Publication number: 0 251 644 Office europeen des brevets A2 EUROPEAN PATENT APPLICATION © Application number: 87305558.6 C11B © int. Ci.«: 9/00 , A61 K 7/46 © Date of filing: 23.06.87 © Priority: 25.06.86 JP 146993/86 © Applicant: Takasago Perfumery Co., Ltd. No. 19-22, Takanawa 3-chome @ Date of publication of application: Minato-ku Tokyo(JP) 07.01.88 Bulletin 88/01 © Inventor: Yamamotc, Takeshi © Designated Contracting States: Takagaso Perfumery Co. Ltd. Kamata Div. CH DE FR GB IT LI NL 5-36-31 Kamata Ohta-ku Tokyo(JP) Inventor: Sakurai, Kazutoshi Takagaso Perfumery Co. Ltd. Kamata Div. 5-36-31 Kamata Ohta-ku Tokyo(JP) Inventor: Watanabe, Susumu Takagaso Perfumery Co. Ltd. Kamata Div. 5-36-31 Kamata Ohta-ku Tokyo(JP) Inventor: Kinosaki, Atsushi Takagaso Perfumery Co. Ltd. Kamata Div. 5-36-31 Kamata Ohta-ku Tokyo(JP) © Representative: Diamond, Bryan Clive et al Gee & Co. Chancery House Chancery Lane London WC2A 1QU(GB) © Perfume composition containing a derivative of hydroxy citronellal. © A perfume composition contains methyl I-3,7-dimethyl-7-hydroxyoctylideneanthranilate of the following formula (I): CM to (I) Q- LU CH3 fa CH3 Xerox Copy Centre 0 251 644 in an amount of 0.1 to 50 wt%, together with other conventional perfume components. Two synthesis routes are given. The compound has an orange-flower note. The composition is less allergenic and is safer than those containing the corresponding d-or dl-form, and it has a less irritating odor and imparts a clean and green note. 0 251 644 PERFUME COMPOSITION CONTAINING A DERIVATIVE OF HYDROXY CITRONELLAL The present invention relates to a perfume composition and, in particular, to a perfume composition having a low sensitizing potential skin. on __ Methyl 3,7-dimethyl-7-hydroxyoctylideneanthranilate is a Schiff base compound, prepared from hydrox- ycitronellal (3,7-dimethyl-7-hydroxyoctanal) and methyl anthranilate. Hydroxycitronellal used as a starting 5 material for the production of this compound is also a synthetic perfume and has chiefly been available in the form of either d-hydroxycitronellal which is obtained by hydrolysis of a sulfurous acid adduct of d- citronellal derived from citronella oil, or dt-hydroxycitronellal which is prepared from di-citronellal which is itself prepared from myrcene. In other words, an I -form of hydroxycitronellal has seldom been used (see 0. Okuda, Koryo Kagaku Soran (Review of Perfume Chemistry), p. 753, Hirokawa Publishing Company, I968). io Therefore, methyl 3,7-dimethyl-7-hydroxyoctylideneanthranilate has generally been known only in its d- or d£-form. Being a classical fragrance raw material having an orange flower note, methyl 3,7-dimethyl-7- hydroxyoctylideneanthranilate has been recognized as an indispensable aroma chemical that is com- pounded for manufacturing perfumes within the class of the floral family (see Steffen and Arctander, Perfume and Flavor Chemicals Monograph, No. I735 (I969)). However, no case has been reported of 75 success in isolating the I -form of methyl 3,7-dimethyl-7-hydroxyoctylideneanthranilate or in identifying its fragrance and properties. There has also been no report on the characteristics or safety features of this compound as a perfume. With the recent concern over the safety of perfumes, there is a global need to create perfumes that present much less hazard to human health. In this connection, it has been reported that hydroxycitronellal which 20 is not only a synthetic perfume per se but also used as a starting material for the production of methyl 3,7-dimethyl-7-hydroxyoctylideneanthranilate has a potential for causing dermatitis when it is used in a cream base (see H. Nakayama, Perfume Allergy and Patch Test in Perfume Chemistry Books, No. I, Fragrance Journal Publishing Company, p. 78 (I983)). This suggests the possibility that the conventionally used methyl 3,7-dimethyl-7-hydroxyoctylideneanthranilate also has a potential for causing contact allergy. If 25 so, this compound cannot be used in the preparation of perfumes of either the citrus or neroli family. Therefore, development of a substitute that has the closest resemblance to the conventional methyl 3,7- dimethyl-7-hydroxyoctylideneanthranilate not only in terms of fragrance but also with respect to other properties such as solubility is strongly desired. The present inventors synthesized various aldehyde compounds, reacted them with methyl anthranilate 30 to Schiff prepare bases, and investigated the safety and other characteristics of these Schiff bases used as perfumes. During the course of these studies, the present inventors established a method of synthesizing t- hydroxycitronellal (see Japanese Patent Application (OPI) No. 4748/I983) with the attendant finding that the 1-form of hydroxycitronellal has a very low level of allergenicity as compared with its d-form. (The term "OPI" as used herein refers to a "published unexamined Japanese patent application".) 35 In addition to the note of fragrance and solubility of the Schiff bases, the present inventors investigated their to potential cause contact allergy (or sensitization) by conducting an allergenicity test on guinea pigs with view a to searching for a substitute that is safer to use and which yet provides a note of fragrance that is not much different from those of the conventional isomers of hydroxycitronellal. As a result, the present inventors found that only methyl 3,7-dimethyl-7-hydroxyoctylideneanthranilate is acceptable because of its 40 balanced properties, i.e., very low sensitizing potential, note for fragrance that is not much different from those of other isomeric forms of hydroxycitronellal, less irritating odor, cleanness, and an added green note. The present invention has been accomplished on the basis of this finding. The present invention provides a perfume composition containing methyl l-3,7-dimethyl-7-hydroxyoc- tylideneanthranilate of the following formula (I): 45 50 0 251 644 k b=N v (I) 70 CH3 (ijjj CH3 75 The single figure is an infrared spectrum of methyl £-3,7-dimethyl-7-hydroxyoctylideneanthranilate produced in Pretion Example I. Methyl I-3,7-dimethyl-7-hydroxyoctylideneanthranilate represented by formula (I) can be prepared by one of the following two routes: (1) (-)-8-Hydroxy-A4-menthen-3-one derived from ( + )-pulegone is reacted with alkaline hydrogen 20 peroxide to obtain ( + )-8-hydroxy-4,5a-epoxyisomenthone which is then reacted with tosyl hydrazine to form (-)-7-hydroxy-3,7-dimethylocto-5-in-l-al which is subsequently hydrogenated (see Helv. Chimica Acta., 54 , I797 (I97I)); and (2) According to the method described in Example 3 in the specification of Japanese Patent Application (OPI) No. 4748/1983 (EP 0068506) or the method described in J. Am. Chem. Soc. , I06, 5208 25 (I984), N,N-diethyl-7-hydroxygeranylamine ((E)-N,N-diethyl-7-hydroxy-3,7-dimethyl-2-octenylamine) or N,N- diethyl-7-hydroxycinerylamine ((Z)-N,N-diethyl-7-hydroxy-3,7-dimethyl-2-octenylamine) is asymmetrically isomerized with [Rh((+)-BINAP)(NBD)]+CIOr or [Rh((-)-BINAP)(NBD)J+CIOr to form an enamine of (-)-7- hydroxycitronellal which is then hydrolyzed, wherein NBD means norbornadiene, and BINAP means 2,2'-bis- (diphenylphosphono-l,l'-binaphthyl. 30 By employing, either one of these methods, (-)-7-hydroxycitronellal having a boiling point of from 85 to 90°C/2 mmHg and a specific rotation [a] £3 of -12° (C = 20, benzene) is obtained. When this substance is reacted with methyl anthranilate by a known method, the intended methyl l-3,7-dimethyl-7-hydroxyoc- tylideneanthranilate of formula (I) is formed. This substance is a yellow viscous liquid having an orange- flower note. 35 The contact allergenic (or sensitizing) potential of this substance was compared with those of the conventional d-and dt-forms of methyl 3,7-dimethyl-7-hydroxyoctylideneanthraniIate by conducting the following maximization test according to the method described in B. Magnusson and A.M. Kligman, J. Inv. Derm., 52, 268-276 (I976). The results were evaluated after the lapse of a predetermined period. The sensitized potential of guinea 40 pigs that were challenged with the l-form after induction with the it-form was weaker than that of those that were challenged with the d-and dl-forms after induction with the d-and dMorms, respectively. The same results were observed such that the sensitized potential of guinea pigs that were challenged with the d-, dl- , or I-form after induction with the dl-form was weaker than that of those that were challenged with d-, £-, and di-forms after induction with the d-or d£-form. In addition, the sensitized potential of guinea pigs that 45 were challenged with the I -form after induction with the d-or d i-form was also of a weaker level in the cross-reaction. For these reasons, the use of the I-form of methyl 3,7-dimethyl-7-hydroxyoctylideneanth- ranilate is recommended. When this compound, i.e., methyl £-3,7-dimethyl-7-hydroxyoctylideneanthranilate, is used in a perfume composition, it can find extensive utility in the manufacture of compounded perfumes in the citrus or neroli so family that have a fragrance of the same orange-flower note as imparted by the heretofore used isomers. This compound may be used in an amount of from 0.1 to 50 wt%, preferably from 0.5 to 20 wt%,-of the perfume composition. In addition to this active compound, the perfume composition of the present invention may contain commonly employed additives for perfumes in appropriate amounts. The perfume composition may be formulated in any desired dosage form. 55 The following examples and test example are provided for the purpose of further illustrating the present invention but are in no sense to be taken as limiting. 0 251 644 PREPARATION EXAMPLE I72 g (I mole) of l-hydroxycitronellal (prepared in accordance with Example 3 of Japanese Patent Application (OPI) No.
Load more

Recommended publications
  • Jason Dandruff Relief Treatment
    JASON DANDRUFF RELIEF TREATMENT - sulfur, salicylic acid shampoo The Hain Celestial Group, Inc Disclaimer: Most OTC drugs are not reviewed and approved by FDA, however they may be marketed if they comply with applicable regulations and policies. FDA has not evaluated whether this product complies. ---------- Drug Facts Sulfur 2.0% Salicylic Acid 2.0% Sulfur 2.0% Controls Dandruff Salicylic Acid 2.0% Controls Seborrheic Dermatitis Controls recurrence of flaking, scaling and itching associated with dandruff Helps prevent seborrheic dermatitis For external use only. Avoid contact with eyes.Rinse eyes throughly with water in case contact occurs.Discontinue use and consult your physician if irritation develops. Keep out of reach of children. If swallowed get medical help or contact Poison Center right away. For best results, use at least three times each week. Wet hair and lather,massage into scalp. Rinse and repeat if desired. Store between 40 to 100 degrees F (4 to 38 degrees C). Aqua (Water), Sodium Cocoyl Isothionate, Disodium Cocoamphodiacetate, Stearic Acid,Potassium Cocoyl Glutamate, Glycerin, Sodium Lauroyl Sarcosinate, Cetyl Alcohol, Olea Europaea (Olive) Fruit Oil (1), Pogostemon Cablin (Patchouli) Oil, Rosmarinus Officinalis (Rosemary) Leaf Oil, Simmondsia Chinensis (Jojoba) Seed Oil (1), Camphor, Dimethyl Sulfone (2), Menthol, Methyl Salicylate, Potassium Hydroxide, Sodium PCA, Xanthan Gum, Benzyl Alcohol, Capryloyl Glycine, Undecylenoyl Glycine, Amyl Cinnamal, Benzyl Benzoate, Hexyl Cinnamal, Hydroxycitronellal, Linalool, Limonene,
    [Show full text]
  • Transient Receptor Potential Channels and Metabolism
    Molecules and Cells Minireview Transient Receptor Potential Channels and Metabolism Subash Dhakal and Youngseok Lee* Department of Bio and Fermentation Convergence Technology, Kookmin University, BK21 PLUS Project, Seoul 02707, Korea *Correspondence: [email protected] https://doi.org/10.14348/molcells.2019.0007 www.molcells.org Transient receptor potential (TRP) channels are nonselective Montell, 2007). These cationic channels were first charac- cationic channels, conserved among flies to humans. Most terized in the vinegar fly, Drosophila melanogaster. While TRP channels have well known functions in chemosensation, a visual mechanism using forward genetic screening was thermosensation, and mechanosensation. In addition to being studied, a mutant fly showed a transient response to being sensing environmental changes, many TRP channels constant light instead of the continuous electroretinogram are also internal sensors that help maintain homeostasis. response recorded in the wild type (Cosens and Manning, Recent improvements to analytical methods for genomics 1969). Therefore, the mutant was named as transient recep- and metabolomics allow us to investigate these channels tor potential (trp). In the beginning, researchers had spent in both mutant animals and humans. In this review, we two decades discovering the trp locus with the germ-line discuss three aspects of TRP channels, which are their role transformation of the genomic region (Montell and Rubin, in metabolism, their functional characteristics, and their 1989). Using a detailed structural permeation property anal- role in metabolic syndrome. First, we introduce each TRP ysis in light-induced current, the TRP channel was confirmed channel superfamily and their particular roles in metabolism. as a six transmembrane domain protein, bearing a structural Second, we provide evidence for which metabolites TRP resemblance to a calcium-permeable cation channel (Mon- channels affect, such as lipids or glucose.
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2008/0299054 A1 Chandar Et Al
    US 20080299054A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2008/0299054 A1 Chandar et al. (43) Pub. Date: Dec. 4, 2008 (54) PERSONAL CARE COMPOSITIONS WITH Publication Classification ENHANCED FRAGRANCE DELVERY (51) Int. Cl. (75) Inventors: Prem Chandar, Closter, NJ (US); A6IR 8/34 (2006.01) Lin Yang, Woodbridge, CT (US) A6II 3/14 (2006.01) A6II 3/17 (2006.01) Correspondence Address: UNILEVER PATENT GROUP (52) U.S. Cl. .............. 424/54; 424/59: 424/65; 424/70.1; 800 SYLVANAVENUE, AG West S. Wing 514/588 ENGLEWOOD CLIFFS, NJ 07632-3100 (US) (57) ABSTRACT (73) Assignee: CONOPCO, INC., d/b/a UNILEVER, Englewood Cliffs, NJ A personal care product is provided which includes a fra (US) grance, a Substituted urea and a quaternary ammonium salt. The Substituted urea and quaternary ammonium salt operate (21) Appl. No.: 11/755,009 together as a scent boosting system to enhance Volatilization offragrance components upon the personal care composition (22) Filed: May 30, 2007 being first applied to human skin or hair. US 2008/0299054 A1 Dec. 4, 2008 PERSONAL CARE COMPOSITIONS WITH structure AB, wherein A is a cationic charged compo ENHANCED FRAGRANCE DELVERY nent of the salt AB, B is an anionic charged component of the salt AB, and BACKGROUND OF THE INVENTION 0013 A has a single quaternized nitrogen atom, at least two hydroxy groups and a molecular weight no 0001 1. Field of the Invention higher than about 250. 0002 The invention concerns personal care compositions which upon application to a human body Surface quickly release fragrance components thereby improving aesthetics DETAILED DESCRIPTION OF THE INVENTION of these compositions.
    [Show full text]
  • Opinion of the Sccnfp Concerning an Initial List of Perfumery Materials Which Must Not Form Part of Cosmetic Products Except
    SCCNFP/0392/00, final OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING AN INITIAL LIST OF PERFUMERY MATERIALS WHICH MUST NOT FORM PART OF COSMETIC PRODUCTS EXCEPT SUBJECT TO THE RESTRICTIONS AND CONDITIONS LAID DOWN adopted by the SCCNFP during the 18th Plenary meeting of 25 September 2001 1. Terms of Reference SCCNFP/0392/00, final Opinion concerning a review on the safety of perfumery materials ____________________________________________________________________________________________ In recent years there has been concern on the safety of fragrance (perfumery) materials. Dermatologists have highlighted the frequency of allergic contact dermatitis from perfumes. Under current legislation, fragrance materials do not fall under all the requirements of Directive 76/768/EEC on cosmetic products. The 6th Amendment (93/35/EEC) provides for the labelling of ingredients on cosmetic products. However, it is not a requirement to label fragrance constituents on the packaging of cosmetic products, current legislation requires only the word parfum. In response to growing concern over this issue, the Commission was asked for positive actions with respect to legislative measures on fragrance materials. 2. Mandate The SCCNFP has been asked to respond to the following questions : 1. Does the SCCNFP agree to the inclusion of all IFRA restricted materials in the Annex III (List of substances which cosmetic products must not contain except subject to restrictions and conditions laid down)? Are the permitted levels recommended by IFRA suitable for use in the Cosmetics Directive 76/768/EEC ? 2. Does the SCCNFP agree that all materials that IFRA recommend should not be used as fragrance compounds are included in Annex II (List of substances which must not form part of the composition of cosmetic products)? 3.
    [Show full text]
  • Kaffir Lime) Leaves Oil
    ACTIVATING EFFECT OF AROMATHERAPY INHALATION WITH Citrus hystrix (KAFFIR LIME) LEAVES OIL ALISA STEPHANIE RASION 11". sfr«.. ¢ý'si: .... : lJ1ii Liý/: r. `t , ýi THESIS SUBMITTED IN FULFILLMENT FOR THE DEGREE OF MASTER OF SCIENCE FACULTY OF SCIENCE AND NATURAL RESOURCES UNIVERSITY OF MALAYSIA SABAH 2018 UNIVERSITI MALAYSIA SABAH BORANGPENGESAHAN STATUS TESIS JUDUL: ACTIVATINGEFFECT OF AROMATHERAPYINHALATION WITH Citrus hystrix (KAFFIR LIME) LEAVESOIL IJAZAH: SARJANA SAINS (KIMIA INDUSTRI) Saya ALISA STEPHANIE RASION, sesi 2016-2018, mengaku membenarkan tesis Sarjana ini disimpan di Perpustakaan Universiti Malaysia Sabah dengan syarat-syarat kegunaan seperti berikut: - " 1. Tesis ini adalah hak milik Universiti Malaysia Sabah 2. Perpustakaan Universiti Malaysia Sabah dibenarkan membuat salinan untuk tujuan pengajian sahaja. 3. Perpustakaan dibenarkan membuat salinan tesis ini sebagai bahan pertukaran antara institusi pengajian tinggi. 4. Sila tandakan (/): üýtºi6r: iýi:: f 11 Hi1ýc11 Uia VIYL, 'ýi ý SULIT (Mengandungi maklumat yang berdarjah keselamatan atau kepentingan Malaysia seperti yang termaktub di dalam AKTA RAHSIA 1972) TERHAD (Mengandungi maklumat TERHADyang telah ditentukan oleh organisasi/badan di mana penyelidikan dijalankan x TIDAK TERHAD DisahkanOleh, NURULAINBINTI ISMAIL PUSTAKAWAIWANAN ABAH ALISA STEPHANIERASION (TandatanganPustakawan) MS1521001T Tarikh :V October 2018 (Prof. Madya. Dr. How Siew Eng) Penyelia DECLARATION I declarethat this thesis and the work presentedin it are my own and has been generatedby me as the result of my own original research. 27t'' September2018 Alisa Sianie Rasion MS1521001T 11 CERTIFICATION NAME ALISA STEPHANIE RASION MATRICNO. MS1521001T TITLE ACTIVATING EFFECT OF AROMATHERAPY INHALATION WITH Citrus hystrix (KAFFIR LIME) LEAVES OIL DEGREE : MASTER OF SCIENCE (INDUSTRIAL CHEMISTRY) VIVA DATE 9THAUGUST 2018 CERTIFIED BY; SIGNATURE SUPERVISOR PROF. MADYA.DR.
    [Show full text]
  • PF155: Fragrance Mix [A]
    the art and science of smart patch testing® PF155: Fragrance Mix [A] Patient information What are some products that may contain fragrance mix [A]? Your patch test result indicates that you have a contact allergy to fragrance Personal Care & Hygiene Products mix [A]. This contact allergy may cause your skin to react when it is exposed to • Baby Products this substance although it may take several days for the symptoms to appear. • Bath Oils Typical symptoms include redness, swelling, itching and fluid-filled blisters. • Cosmetics: – Aftershaves Where is fragrance mix [A] found? – Colognes Fragrance mix [A] contains eight fragrances: Geraniol, Cinnamaldehyde, – Perfumes Hydroxycitronellal, Cinnamyl alcohol, alpha-Amylcinnamaldehyde, Isoeugenol, – Soaps Eugenol, and Sandalwood oil. Fragrances can be found in most products. – Tonics They are used to add flavor or scent to a product or may mask a product’s • Hair Care unpleasant smell. They may come from natural (animals or plants) or • Lotions/Creams synthetic sources. Dental Products • Dental cements How can you avoid contact with fragrance mix [A]? • Impression materials Avoid products that list any of the following names in the ingredients: • Mouthwash • alpha-amylcinnamaldehyde • Periodontal packings • Amyl cinnamal • Toothache drops or gels • Amylcinnamaldehyde • Toothpastes • Cinnamal • Cinnamaldehyde Inside the Home • Cinnamic alcohol • Household Cleaners • Cinnamic aldehyde • Laundry Products: • Cinnamyl alcohol – Detergents – Dryer sheets • Eugenol – Fabric softener • Evernia prunastri • Geraniol Medicaments • Hydroxycitronellal • Analgesics • Isoeugenol • Antiseptics • Sandalwood oil • Topical medication • Santalum album oil Foods (Flavor and Fragrance) • Breath mints • Candy • Cassia oils (cinnamon flavor) • Ice cream • Pastries • Soft drinks *For additional information about products that might contain one of the above listed fragrances, go to the Household Product Database online (householdproducts.nlm.nih.gov) at the United States National Library of Medicine.
    [Show full text]
  • CDI Allergen Info Sheets Fragrance
    FRAGRANCE MIX Your patch test result indicates that you have a contact allergy to fragrance mix. This contact allergy may cause your skin to react when it is exposed to this substance although it may take several days for the symptoms to appear. Typical symptoms include redness, swelling, itching and fluid-filled blisters. Where is fragrance mix found? Fragrance mix contains the following eight substances: Geraniol, Cinnamaldehyde, Hydroxycitronellal, Cinnamyl alcohol, a-Amylcinnamaldehyde, Isoeugenol, Eugenol, and Oak moss. Fragrances can be found in most products. They are used to add flavor or scent to a product or may mask a product’s unpleasant smell. They may come from natural (animals or plants) or synthetic sources. How can you avoid contact with fragrance mix? Avoid products that list any of the following names in the ingredients: • Geraniol • Hydroxycitronellal • cinnamic alcohol • CASRN: 122-40-7 • geraniol alcohol • citronellal hydrate • CASRN: 104-54-1 • Oak moss • CASRN: 106-24-1 • CASRN: 107-75-5 • Isoeugenol • oakmoss oil or extract • Cinnamaldehyde • Eugenol • CASRN: 97-54-1 • Evernia Prunastri Lichen • Cinnamal • CASRN 97-53-0 • Amylcinnamaldehyde Extract • CASRN: 104-55-2 • Cinnamyl alcohol • amyl cinnamal • CASRN: 9000-50-4 What are some products that may contain fragrance mix? Baby products Laundry Products: • Detergents Bath Oils • Dryer Sheets Cosmetics: • Fabric Softener • Aftershaves Lotions/Creams • Colognes • Perfumes Medicaments: • Soaps • Analgesics • Tonics • Antiseptics Cutting fluids: Skin Care ® • LPS
    [Show full text]
  • Environmental Health Criteria 242
    INTERNATIONAL PROGRAMME ON CHEMICAL SAFETY Environmental Health Criteria 242 DERMAL EXPOSURE IOMC INTER-ORGANIZATION PROGRAMME FOR THE SOUND MANAGEMENT OF CHEMICALS A cooperative agreement among FAO, ILO, UNDP, UNEP, UNIDO, UNITAR, WHO, World Bank and OECD This report contains the collective views of an international group of experts and does not necessarily represent the decisions or the stated policy of the World Health Organization The International Programme on Chemical Safety (IPCS) was established in 1980. The overall objec- tives of the IPCS are to establish the scientific basis for assessment of the risk to human health and the environment from exposure to chemicals, through international peer review processes, as a prerequi- site for the promotion of chemical safety, and to provide technical assistance in strengthening national capacities for the sound management of chemicals. This publication was developed in the IOMC context. The contents do not necessarily reflect the views or stated policies of individual IOMC Participating Organizations. The Inter-Organization Programme for the Sound Management of Chemicals (IOMC) was established in 1995 following recommendations made by the 1992 UN Conference on Environment and Development to strengthen cooperation and increase international coordination in the field of chemical safety. The Participating Organizations are: FAO, ILO, UNDP, UNEP, UNIDO, UNITAR, WHO, World Bank and OECD. The purpose of the IOMC is to promote coordination of the policies and activities pursued by the Participating Organizations, jointly or separately, to achieve the sound management of chemicals in relation to human health and the environment. WHO Library Cataloguing-in-Publication Data Dermal exposure. (Environmental health criteria ; 242) 1.Hazardous Substances - poisoning.
    [Show full text]
  • Storage and Sustained Release of Volatile Substances from a Hollow Silica Matrix
    IOP PUBLISHING NANOTECHNOLOGY Nanotechnology 18 (2007) 245705 (6pp) doi:10.1088/0957-4484/18/24/245705 Storage and sustained release of volatile substances from a hollow silica matrix Jiexin Wang1, Haomin Ding2,XiaTao1 and Jianfeng Chen1,2,3 1 Key Lab for Nanomaterials, Ministry of Education, Beijing 100029, People’s Republic of China 2 Research Center of the Ministry of Education for High Gravity Engineering and Technology, Beijing University of Chemical Technology, Beijing 100029, People’s Republic of China E-mail: [email protected] Received 26 December 2006, in final form 26 March 2007 Published 25 May 2007 Online at stacks.iop.org/Nano/18/245705 Abstract Porous hollow silica nanospheres (PHSNSs) prepared by adopting a nanosized CaCO3 template were utilized for the first time as a novel carrier for the storage and sustained release of volatile substances. Two types of volatile substances, Indian pipal from perfumes and peroxyacetic acid from disinfectants, were selected and then tested by one simple adsorption process with two separate comparative carriers, i.e. activated carbon and solid porous silica. It was demonstrated that a high storage capacity . / (9 6mlperfume mgcarrier) of perfume could be achieved in a PHSNS matrix, which was almost 14 times as much as that of activated carbon. The perfume release profiles showed that PHSNSs exhibited sustained multi-stage release behaviour, while the constant release of activated carbon at a low level was discerned. Further, a Higuchi model study proved that the release process of perfume in both carriers followed a Fickian diffusion mechanism. For peroxyacetic acid as a disinfectant model, PHSNSs also displayed a much better delayed-delivery process than a solid porous silica system owing to the existence of unique hollow frameworks.
    [Show full text]
  • Urine Stain Eraser 3412
    SAFETY DATA SHEET 1. Identification Product Identifier Gorilla Urine Stain Eraser Other means of identification Product code PCS-3412 Recommended use Stain remover for carpet. Recommended restrictions Professional use only. Manufacturer/distributor/supplier/importer information Company name Professional Cleaning Supply Address Tulsa 7925 E 40th St. Suite A Tulsa, OK 74145 Phone (918) 250-9000 Oklahoma City 4301 SW 21st St. Oklahoma City, OK 73108 Phone (405) 681-1822 Emergency phone number PERS (800) 633-8253 24 hour Emergency (800) 633-8253 2. Hazard(s) Identification Physical hazards Not classified Health hazards Skin corrosion Category 1 Serious eye damage Category 1 Environmental hazards Not classified. OSHA defined hazards None. Label elements Signal word Danger. Hazard statement Causes severe skin burns and eye damage. Precautionary statement Prevention Do not breathe dusts or mists. Wash hands and exposed skin thoroughly after handling. Wear protective gloves/protective clothing/eye protection/face protection. Response IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. Wash contaminated clothing before reuse. IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a poison center/doctor/medical professional. Specific treatment (see supplemental first aid section on this label) IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do so. Continue rinsing. Storage Store locked up. Disposal Dispose of contents/container in accordance with local/regional/national/international regulations. Hazard(s) not otherwise None. classified (HNOC) Supplemental information None. SDS US Material Name: Gorilla Urine Stain Eraser Page 1 of 7 3.
    [Show full text]
  • FCC 10, Second Supplement the Following Index Is for Convenience and Informational Use Only and Shall Not Be Used for Interpretive Purposes
    Index to FCC 10, Second Supplement The following Index is for convenience and informational use only and shall not be used for interpretive purposes. In addition to effective articles, this Index may also include items recently omitted from the FCC in the indicated Book or Supplement. The monographs and general tests and assay listed in this Index may reference other general test and assay specifications. The articles listed in this Index are not intended to be autonomous standards and should only be interpreted in the context of the entire FCC publication. For the most current version of the FCC please see the FCC Online. Second Supplement, FCC 10 Index / Allura Red AC / I-1 Index Titles of monographs are shown in the boldface type. A 2-Acetylpyrrole, 21 Alcohol, 90%, 1625 2-Acetyl Thiazole, 18 Alcohol, Absolute, 1624 Abbreviations, 7, 3779, 3827 Acetyl Valeryl, 608 Alcohol, Aldehyde-Free, 1625 Absolute Alcohol (Reagent), 5, 3777, Acetyl Value, 1510 Alcohol C-6, 626 3825 Achilleic Acid, 25 Alcohol C-8, 933 Acacia, 602 Acid (Reagent), 5, 3777, 3825 Alcohol C-9, 922 ªAccuracyº, Defined, 1641 Acid-Hydrolyzed Milk Protein, 22 Alcohol C-10, 390 Acesulfame K, 9 Acid-Hydrolyzed Proteins, 22 Alcohol C-11, 1328 Acesulfame Potassium, 9 Acid Calcium Phosphate, 240 Alcohol C-12, 738 Acetal, 10 Acid Hydrolysates of Proteins, 22 Alcohol C-16, 614 Acetaldehyde, 11 Acidic Sodium Aluminum Phosphate, Alcohol Content of Ethyl Oxyhydrate Acetaldehyde Diethyl Acetal, 10 1148 Flavor Chemicals (Other than Acetaldehyde Test Paper, 1636 Acidified Sodium Chlorite
    [Show full text]
  • Not So Sexy: the Health Risks of Secret Chemicals in Fragrances
    Not So Sexy The Health Risks of Secret Chemicals in Fragrance Campaign for Safe Cosmetics and Environmental Working Group NOT SO SEXY THIS REPORT IS STRICTLY EMBARGOED UNTIL MAY 12, 2010. PLEASE DO NOT FORWARD OR COPY. Not So Sexy: The Health Risks of Secret Chemicals in Fragrance by Heather Sarantis, MS, Commonweal; Olga V. Naidenko, PhD, Sean Gray, MS, and Jane Houlihan, MSCE, Environmental Working Group; and Stacy Malkan, Campaign for Safe Cosmetics Additional contributors: Lisa Archer, Breast Cancer Fund; Alexandra Gorman Scranton, Women’s Voices for the Earth; Janet Nudelman, Breast Cancer Fund; Mia Davis, Clean Water Action. The Campaign for Safe Cosmetics would like to thank the following people for their review of sections of this report: Janet Gray, PhD, Vassar College; Russ Hauser, MD, ScD, MPH, Frederick Lee Hisaw Professor of Reproductive Physiology, Professor of Environmental and Occupational Epidemiology, Harvard School of Public Health and Professor of Obstetrics, Gynecology and Reproductive Biology Harvard Medical School; Ted Schettler, MD, MPH, Science and Environmental Health Network; and Anne C. Steinemann, PhD, Professor of Civil and Environmental Engineering, Professor of Public Affairs, University of Washington. Any errors or omissions in this report are the responsibility of the Campaign for Safe Cosmetics. Support for this project was provided by The As You Sow Foundation, The Jacob and Hilda Blaustein Fund, Johnson Family Foundation and The Richard and Rhoda Goldman Fund. Canadian product testing funding provided by Environmental Defence Canada. About the Campaign for Safe Cosmetics The Breast Cancer Fund, a national 501(c)(3) organization The Campaign for Safe Cosmetics is a national coalition focused on preventing breast cancer by identifying and of nonprofit women’s, environmental, public health, faith eliminating the environmental links to the disease, serves and worker safety organizations.
    [Show full text]