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VOLUME 46 CONTENTS

No 1 JANUARY 1991 Page Original articles 1 Risk of tuberculosis in immigrant Asians: culturally acquired immunodeficiency? P J Finch, F J C Millard, J D Maxwell 6 Effect of negative pressure ventilation on arterial blood gas pressures and inspiratory muscle strength during an exacerbation of chronic obstructive disease J M Montserrat, J A Martos, A Alarcon, R Celis, V Plaza, Thorax: first published as on 1 January 1991. Downloaded from C Picado 9 The protective effect of a beta2 agonist against excessive airway narrowing in response to bronchoconstrictor stimuli in and chronic E H Bel, A H Zwinderman, M C Timmers, i H Dijkman, P J Sterk 15 treatment as a risk factor for invasive aspergillosis in patients with lung disease L B Palmer, H E Greenberg, M J Schiff 21 Continuous extrapleural intercostal nerve block after pleurectomy E J Mozell, S Sabanathan, A J Mearns, P J Bickford-Smith, M R Majid, C Zografos 25 Erythropoietin concentrations in obstructive sleep apnoea J M Goldman, R M Ireland, M Berthon-Jones, R R Grunstein, C E Sullivan, J C Biggs 28 Effects ofhypercapnia and hypocapnia on respiratory resistance in normal and asthmatic subjects F J J van den Elshout, C L A van Herwaarden, H Th M Folgering 33 Abnormal lung function associated with asbestos disease of the pleura, the lung, and both: a comparative analysis K H Kilburn, R H Warsaw 39 Cysteine and glutathione concentrations in plasma and fluid after treatment with N-acetylcysteine M M E Bridgeman, M Marsden, W MacNee, D C Flenley, A P Ryle 43 Measures of reversibility in response to bronchodilators in chronic airflow obstruction: relation to airway calibre D C Weir, P Sherwood Burge Review articles 46 3-Cloning the cystic fibrosis gene: implications for diagnosis and treatment D J Porteous, J R Dorin 56 Assisted ventilation 4-Weaning from J Goldstone, J Moxham Short reports 63 Digital gangrene in small cell lung cancer: response to aspirin treatment J E Arrowsmith, M A Woodhead, D H Bevan, E M Nanson, A R C Cummin 65 Peripheral mucoepidermoid tumour of the lung L K Green, T L Gallion, F Gyorkey 67 carcinoma of the thyroid as multifocal bronchial carcinoid tumour J E Clague, M G Pearson, Medullary presenting http://thorax.bmj.com/ A Sharma, W Taylor 68 Anti-basement membrane antibody disease with severe pulmonary haemorrhage and normal renal function A Tobler, E Schurch, H J Altermatt, V Im Hof 70 Antimyeloperoxidase antibodies in the Churg-Strauss syndrome J W Cohen Tervaert, R Goldschmeding, J D Elema, A E G Kr von dem Borne, C G M Kallenberg Conference report 72 Fourth annual North American and 1990 international cystic fibrosis conference J S Elborn Letters to the editor 74 in the assessment of patients with lung collapse for endoscopic laser therapy S K Morcos, on October 2, 2021 by guest. Protected copyright. P B Anderson; P J M George, M C Pearson, R M Rudd, M P Hetzel * Value of washings and brushings at fibreoptic in the diagnosis of lung cancer L Trevisani, P Pazzi, S Sartori, A Potena; P Semple; V H F Mak, M R Hetzel, I D A Johnston * Transcarinal needle aspiration in the diagnosis of mediastinal adenitis in a patient infected with the human immunodeficiency virus C D Sheldon, N C Barnes, D T D Hughes; F Rodriguez de Castro, J Caminero, G Julia Serda, P Cabrera * Homer's syndrome occurring as a complication of pleurectomy D L Connolly Malignant carcinoid tumour of the oesophagus A Siegal, A Swartz, M Aronheim 45 Miscellaneous 76 Book notices 76 Notices

No 2 FEBRUARY 1991 Review 77 The role of high resolution computed tomography in the diagnosis of interstitial lung disease D M Hansell, I H Kerr Original articles 85 Predictors and prevalence of obstructive sleep apnoea and snoring in 1001 middle aged men J R Stradling, J H Crosby 91 Plasma tumour necrosis factor alpha in cystic fibrosis D Norman, J S Elborn, S M Cordon, R J Rayner, M S Wiseman, E J Hiller, D J Shale 96 Tuberculous pleural effusions: increased culture yield with bedside inoculation of pleural fluid and poor diagnostic value of adenosine deaminase G Maartens, E D Bateman 100 Exercise response in 404 young men with asthma: no evidence for a late asthmatic reaction J Karjalainen 105 Prescribed fenoterol and death from asthma in New Zealand, 1981-7: a further case-control study J Grainger, K Woodman, N Pearce, J Crane, C Burgess, A Keane, R Beasley *112 The impact of quitting smoking on symptoms of chronic : results of the Scottish Heart Health Study C A Brown, I K Crombie, W C S Smith, H Tunstall-Pedoe 117 Structure of a human pulmonary acinus N Berend, A C Rynell, H E Ward 122 Effect of terbutaline on bronchoconstriction induced by nebulised pentamidine T R Leigh, J Wiggins, B G Gazzard, J V Collins Review series 124 Cystic fribrosis 4-Abnormalities of airway epithelial function and the implications of the discovery of the cystic fibrosis gene A W Cuthbert 131 Assisted ventilation 5-Non-invasive and domiciliary ventilation: negative pressure techniques J M Shneerson New techniques 136 A video system for investigating disorders during sleep C J Griffiths, B G Cooper, G J Gibson Short reports 141 Flexible bronchoscopy via the laryngeal mask: a new technique C J McNamee, B Meyns, K M Pagliero K M Kerr, 142 Iron lung: bronchoscopic and pathological consequences of aspiration of ferrous sulphate D J Godden, Thorax: first published as on 1 January 1991. Downloaded from S J Watt, J S Legge 144 Use of the Denver pleuroperitoneal shunt in the treatment of secondary to filariasis N D Kitchen, D B Hocken, R M Greenhalgh, D K Kaplan 145 Hypertrophic pulmonary osteoarthropathy in a patient with pulmonary alveolar microlithiasis S Emri, L Coplu, Z T Selfuk, A A Sahin, Y I Baris 147 Peripheral pulmonary adenoid cystic carcinoma with substantial submucosal extension to the proximal H Inoue, A Iwashita, H Kanegae, K Higuchi, Y Fujinaga, I Matsumoto Letters to the editor 149 Trends in respiratory mortality in England and Wales D Strachan - Pericardial effusion after open heart I A D'Cruz, G M Pai; G D Angelini, A J Bryan - Bronchoscopic cryotherapy for advanced bronchial carcinoma P J M George, R M Rudd; D A Walsh, A R Nath, M 0 Maiwand - Tests giving an aetiological diagnosis in pulmonary disease in patients infected with the human immunodeficiency virus C M Parry, H M Evans, N J Beeching, M L Yee; R Miller, D Mitchell * Alveolar partial pressures of carbon dioxide and oxygen measured by a helium washout technique E A Harris; J Jordanoglou, G Tatsis, J Danos, S Gougoulakis, D Orfanidou, M Gaga The biphasic spirogram: a clue to unilateral narrowing of a mainstem bronchus M C P Braat, C M Roos; D Denison; A D Gascoigne, G J Gibson * Jet and ultrasonic nebuliser output: use of a new method for direct measurement of aerosol output R D Hamilton, A Guz Miscellaneous 152 Book notices - Notices

No 3 MARCH 1991 Editorials 153 Tobacco: the third world war J Mackay http://thorax.bmj.com/ 157 Percutaneous biopsy of mediastinal tumours under sonographic guidance K Wernecke Original articles 160 Bone turnover during high dose inhaled corticosteroid treatment N J Ali, S Capewell, M J Ward 165 Oropharyngeal flora and chest infection after upper abdominal surgery J P Dilworth, R J White, E M Brown 168 Palliation of malignant tracheal strictures using silicone T tubes R L Insall, G N Morritt 172 Does the substitution of cisplatin in a standard four drug regimen improve survival in small cell carcinoma of the lung? A comparison of two chemotherapy regimens A P Smith, G Anderson, G Chappell, D R Bowen

175 Forced expiratory indices in normal black Southern African children aged 6-19 years M H Shamssain on October 2, 2021 by guest. Protected copyright. 180 Lung function in primary Sjogren's syndrome: a cross sectional and longitudinal study C Kelly, P Gardiner, B Pal, I Griffiths 184 Effect of a 5-lipoxygenase inhibitor on leukotriene generation and airway responses after allergen challenge in asthmatic patients K P Hui, I K Taylor, G W Taylor, P Rubin, J Kesterson, N C Barnes, P J Barnes 190 Effect of GR32191, a potent thromboxane receptor antagonist, on exercise induced bronchoconstriction in asthma J P Finnerty, 0 P Twentyman, A Harris, J B D Palmer, S T Holgate 193 Relation between nocturnal symptoms and changes in lung function on lying down in asthmatic children A Greenough, L Everett, J Pool, J F Price 197 Platelet activation in nocturnal asthma J F J Morrison, S B Pearson, H G Dean, I R Craig, P N Bramley 201 Paraquat induced in three survivors M Hudson, S B Patel, S W B Ewen, C C Smith, J A R Friend 205 Pneumocystis carinii complicating low dose methotrexate treatment for rheumatoid arthritis A Wollner, J Mohle-Boetani, R E Lambert, J L Perruquet, T A Raffin, J L McGuire Review series 208 Assisted ventilation 6-Non-invasive and domiciliary ventilation: positive pressure techniques M A Branthwaite 213 Cystic fibrosis 5-The current state of for cystic fibrosis R L Smyth, T Higenbottam, J Scott, J Wallwork Short reports 217 Nodular pulmonary amyloidosis occurring in association with pulmonary lymphoma C J Davis, E G Butchart, A R Gibbs 219 Hilar and mediastinal lymphadenopathy in the limited form of Wegener's granulomatosis V M Gutierrez-Rave, M A Ayerza 220 Successful treatment of Bacillus cereus infection with ciprofloxacin A D Gascoigne, J Richards, K Gould, G J Gibson 222 Haemopericardium and cardiac tamponade complicating pulmonary lymphangioleiomyomatosis J Fahy, M Toner, J O'Sullivan, M X FitzGerald Letters to the editor 223 The hyperimmunoglobulinaemia E and recurrent infections syndrome in an adult D Honeybourne, S Maxwell; J-P L'Huillier, P-H Thoreux, P Delaval, B Desrues, E Le Gall, J Kernec, J-F Delambre Miscellaneous 223 Book notices Notices No 4 APRIL 1991 Original articles 225 Difference in pulmonary absorption of inhaled terbutaline in healthy smokers and non-smokers B Schmekel, L Borgstrom, P Wollmer 229 Factors associated with massive fibrosis in T P Ng, S L Chan 233 Clinicopathological study of migratory lung infiltrates Y Miyagawa, N Nagata, N Shigematsu 239 Ceftazidime treatment in cystic fibrosis: resistant organisms in sputum and faeces A M Dalzell, D Sunderland, C A Hart, D P Heaf 242 Effect of cetirizine on exercise induced asthma S K Ghosh, C De Vos, I McIlroy, K R Patel 245 Delivery of propellant soluble drug from a metered dose inhaler H L Ashworth, C G Wilson, E E Sims,

P K Wotton, J G Hardy Thorax: first published as on 1 January 1991. Downloaded from 248 Bronchodilator treatment for partially reversible chronic obstructive airways disease M K Tandon, S G Kailis 252 Effect of positive expiratory pressure breathing in patients with cystic fibrosis C P van der Schans, Th W van der Mark, G de Vries, D A Piers, H Beekhuis, J E Dankert-Roelse, D S Postma, G H Koeter 257 Bacterial colonisation of humidifier attachments on oxygen concentrators prescribed for long term : a district review N Pendleton, J S Cheesbrough, M J Walshaw, C R K Hind 259 Suction drainage: a new approach to the treatment of empyema A R C Cummin, N L Wright, AEA Joseph Review series 261 Cystic fibrosis 6-Gastrointestinal and nutritional aspects H Kopelman Historical note 268 Coarctation of the aorta with dissecting aneurysm and haemopericardium: an account by Joseph Jordan, Manchester, 1830 L Doyle Short reports 270 Thyroid carcinoma presenting as Pancoast's syndrome A Rabano, M La Sala, P Hernandez, J L Barros 272 Intravascular papillary endothelial hyperplasia of superior vena cava: a rare cause of the superior vena cava syndrome J Young Park, M Chung-Park, N Snow Letters to the editor 274 Relation of urinary cotinine concentrations to cigarette smoking and to exposure to other people's smoke P N Lee Life threatening haemoptysis in cystic fibrosis: an alternative therapeutic approach E R Chilvers, R J Fergusson, M L Turner; A K Webb, D Bilton Miscellaneous 274 Book notices Notice Proceedings 277P British Thoracic Society winter meeting 1990 http://thorax.bmj.com/

No 5 MAY 1991 Review 325 Endoscopic palliation of tracheobronchial malignancies M R Hetzel, S G T Smith Original articles 334 Hut lung: a domestically acquired of mixed aetiology in rural women J P Grobbelaar, E D Bateman 341 Silicosis in a Himalayan village population: role of environmental dust T Norboo, P T Angchuk, M Yahya, S R Kamat, F D Porley, B Corrin, I H Kerr, N Bruce, K P Ball on October 2, 2021 by guest. Protected copyright. 344 Carboxyhaemoglobin in women exposed to different cooking fuels D Behera, S Dash, S P Yadav 347 Deaths in adults with notified pulmonary tuberculosis 1983-5 P Cullinan, S K Meredith 351 Bilateral diaphragm paralysis after cardiac surgery with topical hypothermia J Efthimiou, J Butler, M K Benson, S Westaby 355 Effects of allergy and age on responses to salbutamol and ipratropium bromide in moderate asthma and chronic bronchitis C P van Schayck, H Folgering, H Harbers, K L Maas, C van Weel 360 Effect of different bronchodilators on airway smooth muscle responsiveness to contractile agents B Gustafsson, C G A Persson 366 Nocturnal airflow obstruction, histamine, and the autonomic central nervous system in children with allergic asthma W M C van Aalderen, D S Postma, G H Koeter, K Knol 372 Effects of inhaled budesonide on spirometric values, reversibility, airway responsiveness, and cough threshold in smokers with chronic obstructive lung disease B Auffarth, D S Postma, J G R de Monchy, Th W van der Mark, M Boorsma, G H Koeter 378 Labelling of and hayfever by doctors B Sibbald, E Rink Review series 382 Cystic fibrosis 7-Management of cystic fibrosis in different countries: Introduction D J Shale; Mell4ourne P D Phelan, G Bowes; Copenhagen C Koch, N Hoiby; Leeds J M Littlewood, S P Conway, R L Page; Commentary J A Dodge Statistics in respiratory medicine 391 1-Ranges, confidence intervals, and related quantities: what they are and when to use them S Chinn Short reports 394 "Slurry lung": a report of three cases J V Fahy, T Walley, R T N Gibney, M McCabe, M X FitzGerald 396 Occupational asthma due to styrene J P Hayes, L Lambourn, J A C Hopkirk, S R Durham, A J Newman Taylor 397 Long survival after excision of a primary malignant melanoma of the oesophagus F C Hamdy, J H F Smith, A Kennedy, J A C Thorpe 399 Rare intrathoracic complications in acute pancreatitis D J Shewring, H G Naerger, H W Steer Letter to the Editor 400 Intercostal arteriovenous fistula due to plearal biopsy S M Tariq, K McConnochie; J-H Lai, S-J Kao, S-C Lee, (- Y Shen No 6 JUNE 1991 Editorial 401 and wheezing J Goldman, M Muers Original articles 405 Prevalence of asthma among 12 year old children in New Zealand and South Wales: a comparative survey D M J Barry, M L Burr,E S Limb 410 Recovery of the human immunodeficiency virus from fibreoptic bronchoscopes P J V Hanson, D Gor, J R Clarke, M V Chadwick, B Gazzard, D J Jeffries, H Gaya, J V Collins 413 Community acquired pneumonia: aetiology and prognostic index evaluation N K Karalus, R T Cursons, R A Leng, C B Mahood, R P G Rothwell, B Hancock, S Cepulis, M Wawatai, L Coleman

419 Cephalometric measurements in snorers, non-snorers, and patients with sleep apnoea F Maltais, G Carrier, Thorax: first published as on 1 January 1991. Downloaded from Y Cormier, F Siries 424 Pulmonary function in chronic renal failure: effects of dialysis and transplantation A Bush, R Gabriel 429 Asbestos induced pericardial effusion and constrictive pericarditis D Davies, M I J Andrews, J S P Jones 433 Use of transcutaneous oxygen tension, arterial oxygen saturation, and respiratory resistance to assess the response to inhaled methacholine in asthmatic children and normal adults N M Wilson, S B Phagoo, M Silverman 438 Current trends in tuberculosis mortality in England and Wales M Nisar, P D 0 Davies 441 Participation of the cysteinyl leukotrienes in the acute bronchoconstrictor response to inhaled platelet activating factor in man D A Spencer, J M Evans, S E Green, P J Piper, J F Costello 446 Effect of inhaled 15-(s)-hydroxyeicosatetraenoic acid on tracheobronchial clearance in normal human airways C K W Lai, R Polosa, D Pavia, A Hasani, J E Agnew, S W Clarke, S T Holgate 449 Arterial desaturation in HIV positive patients undergoing sputum induction R F Miller, J Buckland, S J G Semple Correction 452 Forced expiratory indices in normal black Southern African children aged 6-19 years (M H Shamssain) Statistics in respiratory medicine 454 2-Repeatability and method comparison S Chinn Short reports 457 Nasal intermittent positive pressure ventilation in the treatment of in obstructive sleep apnoea J Bott, S V Baudouin, J Moxham 459 Left bronchial isomerism associated with bronchomalacia, presenting with intractable P Lee, A Bush, J 0 Warner 461 Malignant in chronic myelomonocytic leukaemia A Manoharan 463 Radiation associated malignant pleural mesothelioma Y Lerman, Y Learman, P Schachter, E Herceg, Y Lieberman, A Yellin 465 Wegener's granulomatosis simulated by a T cell lymphoma of the lung J H Small, A Round, R H W Simpson, A D Ferguson http://thorax.bmj.com/ Letters to the editor 467 Local anaesthesia for fibreoptic bronchoscopy J MacMahon Lung function 8-18 years after intermittent positive pressure ventilation for hyaline membrane disease M Silverman, K N Chan; M J K de Kleine, H M Jansen Ipecacuanha asthma: more lessons C G A Persson Miscellaneous 468 Book notice Notices on October 2, 2021 by guest. Protected copyright.

No 7 JULY 1991 Original articles 469 Initial staging of non-small cell lung cancer: value of routine radioisotope bone scanning F Michel, M Soler, E Imhof, A P Perruchoud 474 Lung function in adult idiopathic scoliosis: a 20 year follow up K Pehrsson, B Bake, S Larsson, A Nachemson 479 Chronic persistent cough and gastro-oesophageal reflux A J Ing, M C Ngu, AB X Breslin 484 Partial atrial resection in advanced lung carcinoma with and without cardiopulmonary bypass T Shirakusa, M Kimura 488 Exercise but not methacholine differentiates asthma from chronic lung disease in children S Godfrey, C Springer, N Noviski, Ch Maayan, A Avital 493 Oral almitrine in treatment of acute respiratory failure and cor pulmonale in patients with an exacerbation of chronic obstructive airways disease P A Bardsley, J Tweney, N Morgan, P Howard 499 Budesonide and terbutaline or terbutaline alone in children with mild asthma: effects on bronchial hyperresponsiveness and diurnal variation in peak flow H J Waalkens, J Gerritsen, G H Koeter, F H Krouwels, W M C van Aalderen, K Knol 504 Increased platelet aggregate formation in patients with chronic airflow obstruction and hypoxaemia J A Wedzicha, D Syndercombe-Court, K C Tan 508 Aetiology of community acquired pneumonia in Valencia, Spain: a multicentre prospective study J Blanquer, R Blanquer, R Borras, D Nauffal, P Morales, R Menindez, I Subias, L Herrero, J Redon, J Pascual New drugs review 512 Phosphodiesterase inhibitors: new opportunities for the treatment of asthma T J Torphy, B J Undem Occasional review 524 Intramural oesophageal dissection J M Hanson, D Neilson, S H Pettit Historical review 528 Surgical treatment of carcinoma of the oesophagus R Hurt Statistics in respiratory medicine 536 3- Scale, parametric methods, and transformations S Chinn Short reports 539 Pulmonary haemosiderosis associated-with left atrial myxoma A A Chaudhry, C M Dobson, F G Simpson 540 Successful pulmonary resection after spontaneous haemopneumothorax in the Eisenmenger syndrome J Au, S P Cusack, W S Walker 542 Squamous cell carcinoma occurring in the wall of a chronic aspergilloma S M Andrew, M Bhattacharjee, D J M Keenan, H Reid Letters to the Editor 544 Risk of tuberculosis in immigrant Asians: culturally acquired immunodeficiency P D 0 Davies; P J Finch, F J C Millard, J D Maxwell * Measures of reversibility in response to bronchodilators in chronic airflow

obstruction G E Packe; D C Weir Thorax: first published as on 1 January 1991. Downloaded from Miscellaneous 543 Book notice 544 Notice Corrections 544 Hut lung: a domestically acquired pneumoconiosis of mixed aetiology in rural women (Grobbelaar and Bateman) 544 Silicosis in a Himalayan village population: role of environmental dust (Norboo et al)

No 8 AUGUST 1991 Editorials 545 BOOP and COP D M Geddes 548 Surveillance of work related and occupational -SWORD A Seaton Original articles 549 Comparison of the prevalence of reversible airways obstruction in rural and urban Zimbabwean children D J Keeley, P Neill, S Gallivan 554 Clinical spectrum of cryptogenic organising R Bellomo, M Finlay, P McLaughlin, E Tai 559 Randomised controlled trial of the effectiveness of a respiratory health worker in reducing impairment, disability, and handicap due to chronic airflow limitation P Littlejohns, C M Baveystock, H Parnell, P W Jones 565 Lung cancer in lifelong non-smokers S Capewell, R Sankaran, D Lamb, M McIntyre, M F Sudlow (on behalf of the Edinburgh Lung Cancer Group) 569 Morbidity in nocturnal asthma: sleep quality and daytime cognitive performance M F Fitzpatrick, H Engleman, K F Whyte, I J Deary, C M Shapiro, N J Douglas 574 Hospital admission rates and the prevalence of asthma symptoms in 20 local authority districts P G J Burney, A 0 Papacosta, C H Withey, J R T Colley, WW Holland 580 Creatine kinase activity in patients with brittle asthma treated with long term subcutaneous terbutaline A P Sykes,

N Lawson, J A Finnegan, J G Ayres http://thorax.bmj.com/ 584 and malignant mesothelioma in patients over the age of 40 J D H Sheard, W Taylor, A Soorae, M G Pearson 586 Value of nocturnal oxygen saturation as a screening test for sleep apnoea B G Cooper, D Veale, C J Griffiths, G J Gibson 589 Accuracy of diagnostic coding ofhospital admissions for cryptogenic fibrosing alveolitis I D A Johnston, C Bleasdale, C R K Hind, AA Woodcock 592 Cyclosporin as a treatment for interstitial lung disease of unknown aetiology J A Moolman, P G Bardin, D J Rossouw, J R Joubert 596 Pleural abrasion: a new method of U U S C S W Fountain Nkere, Griffin, on October 2, 2021 by guest. Protected copyright. 599 Albendazole in the treatment of pulmonary echinococcosis P Aggarwal, J P Wali New techniques 601 Needle aspiration techniques in the diagnosis of pneumonia F Manresa, J Dorca Short reports 604 Ovine psittacosis and in a pregnant woman B A Crosse, P Gomes, MM Muers 606 after a transbronchial biopsy M Naughton, L Irving, A McKenzie 608 Pulmonary dirofilariasis causing a solitary lung mass and pleural effusion A Kido, T Ishida, T Oka, M Tateishi, T Mitsudomi, K Sugimachi 609 Fatal haemoptysis from the pulmonary artery as a late complication of pulmonary irradiation HK Makker, P C Barnes Editorial note 611 Cardiac surgery in Thorax Letter to the editor 611 Suction drainage: a new approach to the treatment of empyema B K Nigam Miscellaneous 611 Book notices* Notice

No 9 SEPTEMBER 1991 Review 613 Bronchoalveolar lavage as a research tool E H Walters, P V Gardiner Original articles 619 Influence ofmode of storage and drying of fodder on thermophilic actinomycete aerocontamination in dairy farms of the Doubs region of France J C Dalphin, D Pernet, G Reboux, J Martinez, A Dubiez, T Barale, A Depierre 624 Ventilatory function and winter fresh fruit consumption in a random sample of British adults D P Strachan, B D Cox, S W Erzinclioglu, D E Walters, M J Whichelow 630 Absorption of "'Cr EDTA across the human nasal airway barriers in the presence of topical histamine L Greiff, P Wollmer, U Pipkorn, C G A Persson 633 Effect of inhaled prostaglandin E, on bronchial reactivity to sodium metabisulphite and methacholine in patients with asthma I D Pavord, A Wisniewski, R Mathur, I Wahedna, A J Knox, A E Tattersf eld 638 Citric acid cough threshold arnd airway responsiveness in asthmatic patients and smokers with chronic airflow obstruction B Auffarth, J G R de Monchy, Th W van der Mark, D S Postma, G H Koeter 643 Reference values and prediction equations for normal lung function in a non-smoking white urban population C M Roberts, K D MacRae, A J Winning, L Adams, W A Seed 651 Spectral and waveform characteristics of fine and coarse crackles M Munakata, H Ukita, I Doi, Y Ohtsuka, Y Masaki, Y Homma, Y Kawakami 658 Microlavage: a technique for determining the volume of epithelial lining fluid D R Baldwin, R Wise, J M Andrews, D Honeybourne 663 Radiographic appearance of nosocomial legionnaires' disease after erythromycin treatment C Domingo, J Roig, F Planas, J Bechini, M Tenesa, J Morera 667 Comparison of the diagnostic yields of disposable and reusable cytology brushes in fibreoptic bronchoscopy Thorax: first published as on 1 January 1991. Downloaded from W J M Kinnear, M J Wilkinson, P D James, I D A Johnston 669 Measurement of twitch transdiaphragmatic pressure: surface versus needle electrode stimulation A Mier, C Brophy Review articles 671 Quality of life measurement for patients undergoing treatment for lung cancer R J Fergusson, A Cull 676 Quality of life measurement for patients with diseases of the airways P W Jones Short reports 683 Pancoast's syndrome due to Pseudomonas aeruginosa infection of the lung apex 0 Vandenplas, C Mercenier, J-P Trigaux, L Delaunois 685 Atypical lipoma of the lung K Matsuba, T Saito, K Ando, T Shirakusa 686 Calcified pseudotumoural mediastinal amyloidosis M CF Jenkins, M Potter Letters to the editor 688 Vocal cord dysfunction and wheezing R McL Niven, C A C Pickering; J Goldman, M Muers * Intercostal arteriovenous fistula due to pleural biopsy J B L Howell; J-H Lai, S-J Kao, C-Y Shen Miscellaneous 688 Book notice Corrections 688 Carboxyhaemoglobin in women exposed to different cooking fuels (Behera et al) - Prevalence of asthma among 12 year old children in New Zealand and South Wales: a comparative survey (Barry et al)

No 10 OCTOBER 1991 Editorials 689 Tuberculosis in the third world S Grzybowski 692 Extracorporeal membrane oxygenation: a breath of fresh air or yesterday's treatment? T W Evans, B F Keogh Original articles 695 Body composition and exercise performance in patients with chronic obstructive pulmonary disease http://thorax.bmj.com/ A M W J Schols, R Mostert, P B Soeters, E F M Wouters 700 Effects of histamine, ethanol, and a detergent on exudation and absorption across guinea pig airway mucosa in vivo L Greiff, I Erjefalt, P Wollmer, U Pipkorn, C G A Persson 706 Prophylactic intranasal a2 interferon and viral exacerbations of chronic respiratory disease M J Wiselka, K G Nicholson, J Kent, J B Cookson, D A J Tyrrell 712 Improvement of drug delivery with a breath actuated pressurised aerosol for patients with poor inhaler technique S P Newman, A W B Weisz, N Talaee, S W Clarke 717 Pulmonary deposition of nebulised amiloride in cystic fibrosis: comparison of two nebulisers S H L Thomas, M J O'Doherty, A Graham, C J Page, P Blower, D M Geddes, T O Nunan on October 2, 2021 by guest. Protected copyright. 722 Diagnostic value of lung clearance of '99Tc DTPA compared with other non-invasive investigations in Pneumocystis carinii pneumonia in AIDS D S Robinson, D A Cunningham, S Dave, J Fleming, D M Mitchell 727 Results of in osteogenic sarcoma with pulmonary metastases S R Carter, R J Grimer, R S Sneath, H R Matthews 732 Measurement of tracheobronchial clearance after sauna in subjects with chronic bronchitis M van Hengstum, J Festen, F Corstens Personal view 734 What makes granulomas tick? D G James Short reports 737 Mycobacteriumfortuitum treated with ciprofloxacin J Vadakekalam, M J Ward 738 Computed tomography and magnetic resonance findings in lipoid pneumonia J M Brechot, J N Buy, J P Laaban, J Rochemaure Letters to the editor 740 Percutaneous biopsy of mediastinal tumours under sonographic guidance M N Sheppard; K Wernecke, W Bocker - The laryngeal mask airway and flexible bronchoscopy J Brimacombe Miscellaneous 740 New editor of Thorax * Notices Proceedings 741P British Thoracic Society summer meeting 1991

No 11 NOVEMBER 1991 Editorials 787 Alternative and complementary medicine for asthma D J Lane, T V Lane 798 Future plans for Thorax S G Spiro Review 799 Acupuncture and asthma: a review of controlled trials J Kleijnen, G ter Riet, P Knipschild Original articles 803 Vertebral fractures in steroid dependent asthma and involutional osteoporosis: a comparative study M Luengo, C Picado, L Del Rio, N Guafiabens, J M Montserrat, J Setoain 807 Self reported snoring and daytime sleepiness in men aged 35-65 years J R Stradling, J H Crosby, C D Payne 811 Effect of inhaled budesonide on bronchial reactivity to histamine, exercise, and eucapnic dry air hyperventilation in patients with asthma A S Vathenen, A J Knox, A Wisniewski, A E Tattersfield 817 Effect of terbutaline on mucociliary clearance in asthmatic and healthy subjects after from a pressurised inhaler and a dry powder inhaler J Mortensen, S Groth, P Lange, F Hermansen 824 Circulating plasma concentrations of atrial natriuretic peptide and catecholamines in response to maximal exercise in normal and asthmatic subjects G Hulks, A F Mohammed, A G Jardine, J M C Connell, N C Thomson 829 Changes in atrial natriuretic peptide concentrations during intravenous saline infusion in hypoxic cor pulmonale A G Stewart, P A Bardsley, S V Baudouin, J C Waterhouse, J S Thompson, A H Morice, P Howard 835 Increased expression of growth factor genes for macrophages and fibroblasts in bronchoalveolar lavage cells of a J K Heidorn, W Petermann, B Bewig, patient with pulmonary histiocytosis X J Barth, H Kreipe, H Radzun, Thorax: first published as on 1 January 1991. Downloaded from M R Parwaresch 839 Treatment of pulmonary aspergilloma with itraconazole J H Campbell, J H Winter, M D Richardson, G S Shankland, S W Banham Review series New perspectives in lung cancer: 842 Introduction S G Spiro 843 1-Neuroendocrine differentiation in lung tumours M N Sheppard Short reports 851 Diffuse pulmonary angiomatosis G J Canny, E Cutz, I B MacLusky, H Levison 853 Achilles tendon rupture: an underrated complication of corticosteroid treatment D M Newnham, J G Douglas, J S Legge, J A R Friend 855 Bronchial compression as a result of lung hemiation after K F Whyte, G McMahon, A J A Wightman, E W J Cameron 857 Synchronous double primary lung cancers of squamous and neuroendocrine type associated with cryptogenic fibrosing alveolitis J-W Seo, J-G Im, Y-W Kim, J-H Kim, M N Sheppard 859 Unintentional percutaneous aspiration of a pleural hydatid cyst M A Al Karawi, A R El Shiekh Mohamed, B 0 El Tayeb, M I Yasawy Letters to the editors 861 Endoscopic palliation of tracheobronchial malignancies J P Homasson; M R Hetzel * Pulmonary function in chronic renal failure: effect of dialysis and transplantation J Egan, S Kalra, A Woodcock; A Bush * Silicosis in a Himalayan village population: role of environmental dust FA Al Kassimi, S A Al Majed, M S Al Hajjaj, N Hawass; T Norboo, N Bruce, K P Ball Miscellaneous 862 Book notice http://thorax.bmj.com/ No 12 DECEMBER 1991 Original articles 863 Prevalence ofobstructive lung disease in a general population: relation to occupational title and exposure to some airborne agents P S Bakke, V Baste, R Hanoa, A Gulsvik 871 Interphase nucleolar organiser regions and survival in squamous cell carcinoma of the bronchus: a 10 year follow up study of 138 cases D A R Boldy, J G Ayres, J Crocker, J A H Waterhouse, M Gilthorpe 878 Correlation of morphological patterns of nucleoli in alveolar macrophages with HLA-DR antigen expression in sarcoidosis W Popp, F J Wachtler 881 Cystic fibrosis: current survival and population estimates to the year 2000 J S Elborn, D J Shale, J R Britton

886 Characteristics ofattenders and non-attenders at an asthma education programme R Yoon, D K McKenzie, on October 2, 2021 by guest. Protected copyright. D A Miles, A Bauman 891 Effect of a volumatic spacer and mouth rinsing on systemic absorption of inhaled from a metered dose inhaler and dry powder inhaler 0 Selroos, M Halme 895 Epidemiology of seasonal and perennial rhinitis: clinical presentation and medical history B Sibbald, E Rink 902 Pneumococcal capsular antigen detection and pneumococcal serology in patients with community acquired pnetumonia W G Boersma, A L6wenberg, Y Holloway, H Kuttschratter, J A M Snijder, G H Koeter 907 Effect of cigarette smoking on evolution of ventilatory lung function in young adults: an eight year longitudinal study M S Jaakkola, P Ernst, J J K Jaakkola, L W N'gan'ga, M R Becklake 914 Long term effects of smoke inhalation in survivors of the King's Cross underground station fire P W Fogarty, P J M George, M Solomon, S G Spiro, R F Armstrong 919 Familial idiopathic granulomatosis: sarcoidosis and Crohn's disease in two Indian families P Bambery, U Kaur, S R Bhusnurmath, J B Dilawari 922 A school microepidemic of tuberculosis C P Bredin, M Godfrey, J McKiernan Review series 924 New perspectives in lung cancer-2: Growth factors and lung cancer P J Woll Short reports 930 Spontaneous hypoglycaemia due to a pleural fibroma: role of insulin like growth factors E A Masson, I A MacFarlane, D Graham, P Foy 932 Spontaneous hypoglycaemia and pleural fibroma: role of insulin like growth factors N E Moat, J D Teale, R E Lea, A W Matthews 933 Endoscopic bougie and balloon dilatation of multiple bronchial stenoses: 10 year follow up J B Ball, J C Delaney, CC Evans, R J Donnelly, C R K Hind 936 Pneumocystis carinii pneumonia as a complication of methotrexate treatment of asthma L M Kuitert, A C Harrison Letters to the Editor 938 Cephalometric measurements in snorers, non-snorers, and patients with sleep apnoea R J 0 Davies, J R Stradling; F Siriis - Intramural oesophageal dissection K Moghissi Miscellaneous 938 Notice 939 Index