VOLUME 46 CONTENTS No 1 JANUARY 1991 Page Original articles 1 Risk of tuberculosis in immigrant Asians: culturally acquired immunodeficiency? P J Finch, F J C Millard, J D Maxwell 6 Effect of negative pressure ventilation on arterial blood gas pressures and inspiratory muscle strength during an exacerbation of chronic obstructive lung disease J M Montserrat, J A Martos, A Alarcon, R Celis, V Plaza, Thorax: first published as on 1 January 1991. Downloaded from C Picado 9 The protective effect of a beta2 agonist against excessive airway narrowing in response to bronchoconstrictor stimuli in asthma and chronic obstructive lung disease E H Bel, A H Zwinderman, M C Timmers, i H Dijkman, P J Sterk 15 Corticosteroid treatment as a risk factor for invasive aspergillosis in patients with lung disease L B Palmer, H E Greenberg, M J Schiff 21 Continuous extrapleural intercostal nerve block after pleurectomy E J Mozell, S Sabanathan, A J Mearns, P J Bickford-Smith, M R Majid, C Zografos 25 Erythropoietin concentrations in obstructive sleep apnoea J M Goldman, R M Ireland, M Berthon-Jones, R R Grunstein, C E Sullivan, J C Biggs 28 Effects ofhypercapnia and hypocapnia on respiratory resistance in normal and asthmatic subjects F J J van den Elshout, C L A van Herwaarden, H Th M Folgering 33 Abnormal lung function associated with asbestos disease of the pleura, the lung, and both: a comparative analysis K H Kilburn, R H Warsaw 39 Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with N-acetylcysteine M M E Bridgeman, M Marsden, W MacNee, D C Flenley, A P Ryle 43 Measures of reversibility in response to bronchodilators in chronic airflow obstruction: relation to airway calibre D C Weir, P Sherwood Burge Review articles 46 Cystic fibrosis 3-Cloning the cystic fibrosis gene: implications for diagnosis and treatment D J Porteous, J R Dorin 56 Assisted ventilation 4-Weaning from mechanical ventilation J Goldstone, J Moxham Short reports 63 Digital gangrene in small cell lung cancer: response to aspirin treatment J E Arrowsmith, M A Woodhead, D H Bevan, E M Nanson, A R C Cummin 65 Peripheral mucoepidermoid tumour of the lung L K Green, T L Gallion, F Gyorkey 67 carcinoma of the thyroid as multifocal bronchial carcinoid tumour J E Clague, M G Pearson, Medullary presenting http://thorax.bmj.com/ A Sharma, W Taylor 68 Anti-basement membrane antibody disease with severe pulmonary haemorrhage and normal renal function A Tobler, E Schurch, H J Altermatt, V Im Hof 70 Antimyeloperoxidase antibodies in the Churg-Strauss syndrome J W Cohen Tervaert, R Goldschmeding, J D Elema, A E G Kr von dem Borne, C G M Kallenberg Conference report 72 Fourth annual North American and 1990 international cystic fibrosis conference J S Elborn Letters to the editor 74 Bronchography in the assessment of patients with lung collapse for endoscopic laser therapy S K Morcos, on October 2, 2021 by guest. 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P B Anderson; P J M George, M C Pearson, R M Rudd, M P Hetzel * Value of washings and brushings at fibreoptic bronchoscopy in the diagnosis of lung cancer L Trevisani, P Pazzi, S Sartori, A Potena; P Semple; V H F Mak, M R Hetzel, I D A Johnston * Transcarinal needle aspiration in the diagnosis of mediastinal adenitis in a patient infected with the human immunodeficiency virus C D Sheldon, N C Barnes, D T D Hughes; F Rodriguez de Castro, J Caminero, G Julia Serda, P Cabrera * Homer's syndrome occurring as a complication of pleurectomy D L Connolly Malignant carcinoid tumour of the oesophagus A Siegal, A Swartz, M Aronheim 45 Miscellaneous 76 Book notices 76 Notices No 2 FEBRUARY 1991 Review 77 The role of high resolution computed tomography in the diagnosis of interstitial lung disease D M Hansell, I H Kerr Original articles 85 Predictors and prevalence of obstructive sleep apnoea and snoring in 1001 middle aged men J R Stradling, J H Crosby 91 Plasma tumour necrosis factor alpha in cystic fibrosis D Norman, J S Elborn, S M Cordon, R J Rayner, M S Wiseman, E J Hiller, D J Shale 96 Tuberculous pleural effusions: increased culture yield with bedside inoculation of pleural fluid and poor diagnostic value of adenosine deaminase G Maartens, E D Bateman 100 Exercise response in 404 young men with asthma: no evidence for a late asthmatic reaction J Karjalainen 105 Prescribed fenoterol and death from asthma in New Zealand, 1981-7: a further case-control study J Grainger, K Woodman, N Pearce, J Crane, C Burgess, A Keane, R Beasley *112 The impact of quitting smoking on symptoms of chronic bronchitis: results of the Scottish Heart Health Study C A Brown, I K Crombie, W C S Smith, H Tunstall-Pedoe 117 Structure of a human pulmonary acinus N Berend, A C Rynell, H E Ward 122 Effect of terbutaline on bronchoconstriction induced by nebulised pentamidine T R Leigh, J Wiggins, B G Gazzard, J V Collins Review series 124 Cystic fribrosis 4-Abnormalities of airway epithelial function and the implications of the discovery of the cystic fibrosis gene A W Cuthbert 131 Assisted ventilation 5-Non-invasive and domiciliary ventilation: negative pressure techniques J M Shneerson New techniques 136 A video system for investigating breathing disorders during sleep C J Griffiths, B G Cooper, G J Gibson Short reports 141 Flexible bronchoscopy via the laryngeal mask: a new technique C J McNamee, B Meyns, K M Pagliero K M Kerr, 142 Iron lung: bronchoscopic and pathological consequences of aspiration of ferrous sulphate D J Godden, Thorax: first published as on 1 January 1991. Downloaded from S J Watt, J S Legge 144 Use of the Denver pleuroperitoneal shunt in the treatment of chylothorax secondary to filariasis N D Kitchen, D B Hocken, R M Greenhalgh, D K Kaplan 145 Hypertrophic pulmonary osteoarthropathy in a patient with pulmonary alveolar microlithiasis S Emri, L Coplu, Z T Selfuk, A A Sahin, Y I Baris 147 Peripheral pulmonary adenoid cystic carcinoma with substantial submucosal extension to the proximal bronchus H Inoue, A Iwashita, H Kanegae, K Higuchi, Y Fujinaga, I Matsumoto Letters to the editor 149 Trends in respiratory mortality in England and Wales D Strachan - Pericardial effusion after open heart surgery I A D'Cruz, G M Pai; G D Angelini, A J Bryan - Bronchoscopic cryotherapy for advanced bronchial carcinoma P J M George, R M Rudd; D A Walsh, A R Nath, M 0 Maiwand - Tests giving an aetiological diagnosis in pulmonary disease in patients infected with the human immunodeficiency virus C M Parry, H M Evans, N J Beeching, M L Yee; R Miller, D Mitchell * Alveolar partial pressures of carbon dioxide and oxygen measured by a helium washout technique E A Harris; J Jordanoglou, G Tatsis, J Danos, S Gougoulakis, D Orfanidou, M Gaga The biphasic spirogram: a clue to unilateral narrowing of a mainstem bronchus M C P Braat, C M Roos; D Denison; A D Gascoigne, G J Gibson * Jet and ultrasonic nebuliser output: use of a new method for direct measurement of aerosol output R D Hamilton, A Guz Miscellaneous 152 Book notices - Notices No 3 MARCH 1991 Editorials 153 Tobacco: the third world war J Mackay http://thorax.bmj.com/ 157 Percutaneous biopsy of mediastinal tumours under sonographic guidance K Wernecke Original articles 160 Bone turnover during high dose inhaled corticosteroid treatment N J Ali, S Capewell, M J Ward 165 Oropharyngeal flora and chest infection after upper abdominal surgery J P Dilworth, R J White, E M Brown 168 Palliation of malignant tracheal strictures using silicone T tubes R L Insall, G N Morritt 172 Does the substitution of cisplatin in a standard four drug regimen improve survival in small cell carcinoma of the lung? A comparison of two chemotherapy regimens A P Smith, G Anderson, G Chappell, D R Bowen 175 Forced expiratory indices in normal black Southern African children aged 6-19 years M H Shamssain on October 2, 2021 by guest. Protected copyright. 180 Lung function in primary Sjogren's syndrome: a cross sectional and longitudinal study C Kelly, P Gardiner, B Pal, I Griffiths 184 Effect of a 5-lipoxygenase inhibitor on leukotriene generation and airway responses after allergen challenge in asthmatic patients K P Hui, I K Taylor, G W Taylor, P Rubin, J Kesterson, N C Barnes, P J Barnes 190 Effect of GR32191, a potent thromboxane receptor antagonist, on exercise induced bronchoconstriction in asthma J P Finnerty, 0 P Twentyman, A Harris, J B D Palmer, S T Holgate 193 Relation between nocturnal symptoms and changes in lung function on lying down in asthmatic children A Greenough, L Everett, J Pool, J F Price 197 Platelet activation in nocturnal asthma J F J Morrison, S B Pearson, H G Dean, I R Craig, P N Bramley 201 Paraquat induced pulmonary fibrosis in three survivors M Hudson, S B Patel, S W B Ewen, C C Smith, J A R Friend 205 Pneumocystis carinii pneumonia complicating low dose methotrexate treatment for rheumatoid arthritis A Wollner, J Mohle-Boetani, R E Lambert, J L Perruquet, T A Raffin, J L McGuire Review series 208 Assisted ventilation 6-Non-invasive and domiciliary ventilation: positive pressure techniques M A Branthwaite 213 Cystic fibrosis 5-The current state of lung transplantation for cystic fibrosis R L Smyth, T Higenbottam, J Scott, J Wallwork Short reports 217 Nodular pulmonary amyloidosis occurring in association with pulmonary lymphoma C J Davis, E G Butchart, A R Gibbs 219 Hilar and mediastinal lymphadenopathy in the limited form of Wegener's granulomatosis V M Gutierrez-Rave, M A Ayerza 220 Successful treatment of Bacillus cereus infection with ciprofloxacin A D Gascoigne, J Richards, K Gould, G