January 31, 2012 u vol. 109 u no. 5 u 1355–1808

Cover image: A bright pink seed pod and older senescent seed pods harboring black seeds are shown on the terminal structure, called a cephalium, of a Melocactus plant. Fang Chen et al. found that the dark coats enveloping the seeds of Melocactus, other cactus species, and the vanilla orchid contain a lignin polymer formed by the oxidative polymerization of an unusual monolignol known as caffeyl alcohol. The findings could help researchers develop lignin bioengineering methods while also providing insights into the diversity of land plants. See the article by Chen et al. on pages 1772–1777. Image courtesy of Broderick Stearns (Samuel Roberts Noble Foundation, Ardmore, OK). From the Cover

1772 Lignin polymers in nature 1396 Extraterrestrial quasicrystals 1437 Magnetic fields and enzyme reactions 1607 Timing cytokine secretion from T cells 1691 Antibiotics in agriculture

Contents COMMENTARIES 1357 Are biochemical reactions affected by weak magnetic fields? THIS WEEK IN PNAS P. J. Hore See companion article on page 1437

1355 In This Issue 1359 Travels in time: Assessing the functional complexity of T cells W. Nicholas Haining See companion article on page 1607 LETTERS (ONLINE ONLY)

E206 Femtosecond laser vaporization that preserves PNAS PLUS (AUTHOR SUMMARIES) protein-folded structure: An unproven idea Kathrin Breuker, Owen S. Skinner, and Fred W. McLafferty BIOLOGICAL SCIENCES E207 Reply to Breuker et al.: How laser electrospray mass spectrometry (LEMS) measures condensed phase BIOCHEMISTRY protein structure, not vacuum structure John J. Brady, Elizabeth J. Judge, and Robert J. Levis 1361 Mechanism of proton/substrate coupling in the heptahelical lysosomal transporter cystinosin E208 Are low-frequency songs sexually selected, and do they Raquel Ruivo, Gian Carlo Bellenchi, Xiong Chen, Giovanni lose their potency in male–female interactions under Zifarelli, Corinne Sagné, Cécile Debacker, Michael Pusch, noisy conditions? Stéphane Supplisson, and Bruno Gasnier Marcel Eens, Hector Fabio Rivera-Gutierrez, See full research article on page E210 of www.pnas.org and Rianne Pinxten

E209 Reply to Eens et al.: Urban noise can alter sexual BIOPHYSICS AND COMPUTATIONAL BIOLOGY selection on bird song 1363 Full-length myosin Va exhibits altered gating during Wouter Halfwerk, Sander Bot, Jasper Buikx, Marco van der processive movement on actin Velde, Jan Komdeur, Carel ten Cate, and Hans Slabbekoorn Jessica M. Armstrong, Elena Krementsova, Arthur J. Michalek, Aoife T. Heaslip, Shane R. Nelson, Kathleen M. Trybus, and David M. Warshaw Free online through the PNAS open access option. See full research article on page E218 of www.pnas.org

PNAS u January 31, 2012 u vol. 109 u no. 5 u iii–viii Downloaded by guest on September 24, 2021 DEVELOPMENTAL BIOLOGY RETROSPECTIVE 1365 The channel kinase, TRPM7, is required for early embryonic development Jie Jin, Long-Jun Wu, Janice Jun, Xiping Cheng, Haoxing Xu, 1379 Anthony E. Siegman: Laser pioneer, Optical Society Nancy C. Andrews, and David E. Clapham president, friend, and colleague See full research article on page E225 of www.pnas.org Stephen E. Harris

EVOLUTION INAUGURAL ARTICLES 1367 Evolution of patterns on Conus shells Zhenqiang Gong, Nichilos J. Matzke, Bard Ermentrout, 1380 Molecular architecture of the 26S proteasome Dawn Song, Jann E. Vendetti, Montgomery Slatkin, holocomplex determined by an integrative approach and George Oster Keren Lasker, Friedrich Förster, Stefan Bohn, Thomas See full research article on page E234 of www.pnas.org Walzthoeni, Elizabeth Villa, Pia Unverdorben, Florian Beck, Ruedi Aebersold, Andrej Sali, and Wolfgang Baumeister MEDICAL SCIENCES 1388 Functional profiling of neurons through cellular neuropharmacology 1368 Glycogen synthase kinase 3β transfers cytoprotective Russell W. Teichert, Nathan J. Smith, Shrinivasan signaling through connexin 43 onto mitochondrial Raghuraman, Doju Yoshikami, Alan R. Light, ATP-sensitive K+ channels and Baldomero M. Olivera Dennis Rottlaender, Kerstin Boengler, Martin Wolny, Astrid Schwaiger, Lukas J. Motloch, Michel Ovize, Rainer Schulz, Gerd Heusch, and Uta C. Hoppe See full research article on page E242 of www.pnas.org PHYSICAL SCIENCES 1370 Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as APPLIED PHYSICAL SCIENCES a central tumor suppressive complex in pancreatic cancer 1396 Evidence for the extraterrestrial origin of A. Hunter Shain, Craig P. Giacomini, Karen Matsukuma, a natural quasicrystal Collins A. Karikari, Murali D. Bashyam, Manuel Hidalgo, Luca Bindi, John M. Eiler, Yunbin Guan, Lincoln S. Hollister, Anirban Maitra, and Jonathan R. Pollack Glenn MacPherson, Paul J. Steinhardt, and Nan Yao See full research article on page E252 of www.pnas.org 1402 Unidirectionally aligned line patterns driven by entropic effects on faceted surfaces MICROBIOLOGY Sung Woo Hong, June Huh, Xiaodan Gu, Dong Hyun Lee, Won Ho Jo, Soojin Park, Ting Xu, and Thomas P. Russell 1372 Systematic identification of interactions between host cell proteins and E7 oncoproteins from diverse 1506 Spatial organization of the extracellular matrix regulates human papillomaviruses cell–cell junction positioning Elizabeth A. White, Mathew E. Sowa, Min Jie Alvin Tan, Qingzong Tseng, Eve Duchemin-Pelletier, Alexandre Sheila Jeudy, Sebastian D. Hayes, Sreevidya Santha, Deshiere, Martial Balland, Hervé Guillou, Karl Münger, J. Wade Harper, and Peter M. Howley Odile Filhol, and Manuel Théry See full research article on page E260 of www.pnas.org CHEMISTRY NEUROSCIENCE 1407 Coaxial multishell nanowires with high-quality electronic interfaces and tunable optical 1374 Distinct energy metabolism of auditory and vestibular cavities for ultrathin photovoltaics sensory epithelia revealed by quantitative mass Thomas J. Kempa, James F. Cahoon, Sun-Kyung Kim, spectrometry using MS2 intensity Robert W. Day, David C. Bell, Hong-Gyu Park, Kateri J. Spinelli, John E. Klimek, Phillip A. Wilmarth, and Charles M. Lieber Jung-Bum Shin, Dongseok Choi, Larry L. David, and Peter G. Gillespie 1413 Constant-speed vibrational signaling along See full research article on page E268 of www.pnas.org polyethyleneglycol chain up to 60-Å distance Zhiwei Lin and Igor V. Rubtsov 1376 GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses 1467 Sampling protein motion and solvent effect during in bed nucleus of the stria terminalis ligand binding Tiffany A. Wills, Jason R. Klug, Yuval Silberman, Anthony J. Vittorio Limongelli, Luciana Marinelli, Sandro Cosconati, Baucum, Carl Weitlauf, Roger J. Colbran, Eric Delpire, Concettina La Motta, Stefania Sartini, Laura Mugnaini, and Danny G. Winder Federico Da Settimo, Ettore Novellino, See full research article on page E278 of www.pnas.org and Michele Parrinello

EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES 1584 Carnivorous dinocephalian from the Middle Permian of QNAS Brazil and tetrapod dispersal in Pangaea Juan Carlos Cisneros, Fernando Abdala, Saniye 1378 QnAs with Harald zur Hausen Atayman-Güven, Bruce S. Rubidge, A. M. Celâl Sxengör, Catherine Kolf and Cesar L. Schultz

iv u www.pnas.org Downloaded by guest on September 24, 2021 1589 Exceptionally preserved crustaceans from western 1449 Critical role of a transmembrane lysine in Canada reveal a cryptic Cambrian radiation aminophospholipid transport by mammalian

Thomas H. P. Harvey, Maria I. Vélez, photoreceptor P4-ATPase ATP8A2 and Nicholas J. Butterfield Jonathan A. Coleman, Anna L. Vestergaard, Robert S. Molday, Bente Vilsen, and Jens Peter Andersen ENGINEERING 1455 Differential regulation of the activity of deleted in liver 1607 Polyfunctional responses by human T cells result from cancer 1 (DLC1) by tensins controls cell migration sequential release of cytokines and transformation Qing Han, Neda Bagheri, Elizabeth M. Bradshaw, David A. Xuan Cao, Courtney Voss, Bing Zhao, Tomonori Kaneko, Hafler, Douglas A. Lauffenburger, and J. Christopher Love and Shawn Shun-Cheng Li See Commentary on page 1359 1461 Protein-binding dynamics imaged in a living cell Yael Phillip, Vladimir Kiss, and Gideon Schreiber PHYSICS 1437 Reexamination of magnetic isotope and field effects on adenosine triphosphate production by creatine kinase BIOPHYSICS AND COMPUTATIONAL BIOLOGY Darragh Crotty, Gary Silkstone, Soumya Poddar, Richard 1380 Molecular architecture of the 26S proteasome Ranson, Adriele Prina-Mello, Michael T. Wilson, holocomplex determined by an integrative approach and J. M. D. Coey Keren Lasker, Friedrich Förster, Stefan Bohn, Thomas See Commentary on page 1357 Walzthoeni, Elizabeth Villa, Pia Unverdorben, Florian Beck, 1473 Tracking energy transfer between light harvesting Ruedi Aebersold, Andrej Sali, and Wolfgang Baumeister complex 2 and 1 in photosynthetic membranes grown 1467 Sampling protein motion and solvent effect during under high and low illumination ligand binding Larry Lüer, Vladimíra Moulisová, Sarah Henry, Dario Polli, Vittorio Limongelli, Luciana Marinelli, Sandro Cosconati, Tatas H. P. Brotosudarmo, Sajjad Hoseinkhani, Daniele Concettina La Motta, Stefania Sartini, Laura Mugnaini, Brida, Guglielmo Lanzani, Giulio Cerullo, Federico Da Settimo, Ettore Novellino, and Richard J. Cogdell and Michele Parrinello

1473 Tracking energy transfer between light harvesting complex 2 and 1 in photosynthetic membranes grown SOCIAL SCIENCES under high and low illumination Larry Lüer, Vladimíra Moulisová, Sarah Henry, Dario Polli, ANTHROPOLOGY Tatas H. P. Brotosudarmo, Sajjad Hoseinkhani, Daniele Brida, Guglielmo Lanzani, Giulio Cerullo, 1755 Preceramic maize from Paredones and Huaca Prieta, Peru and Richard J. Cogdell Alexander Grobman, Duccio Bonavia, Tom D. Dillehay, Dolores R. Piperno, José Iriarte, and Irene Holst 1479 Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopy ECONOMIC SCIENCES Eri Sakata, Stefan Bohn, Oana Mihalache, Petra Kiss, Florian Beck, Istvan Nagy, Stephan Nickell, Keiji Tanaka, Yasushi 1419 Dissociable neural representations of reinforcement and Saeki, Friedrich Förster, and Wolfgang Baumeister belief prediction errors underlie strategic learning Lusha Zhu, Kyle E. Mathewson, and Ming Hsu 1485 Folding energy landscape of the thiamine pyrophosphate riboswitch aptamer 1425 Commodity durability, trader specialization, and Peter C. Anthony, Christian F. Perez, Cuauhtémoc market performance García-García, and Steven M. Block John Dickhaut, Shengle Lin, David Porter, and Vernon Smith 1490 β-Bulge triggers route-switching on the functional PSYCHOLOGICAL AND COGNITIVE SCIENCES landscape of interleukin-1β Dominique T. Capraro, Melinda Roy, José N. Onuchic, 1431 Infants deploy selective attention to the mouth of Shachi Gosavi, and Patricia A. Jennings a talking face when learning speech David J. Lewkowicz and Amy M. Hansen-Tift 1494 Automated selection of stabilizing mutations in designed and natural proteins Benjamin Borgo and James J. Havranek

BIOLOGICAL SCIENCES 1500 Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase BIOCHEMISTRY substrate recruitment Seamus Morrone, Zhihong Cheng, Randall T. Moon, fi 1437 Reexamination of magnetic isotope and eld effects on Feng Cong, and Wenqing Xu adenosine triphosphate production by creatine kinase Darragh Crotty, Gary Silkstone, Soumya Poddar, Richard Ranson, Adriele Prina-Mello, Michael T. Wilson, CELL BIOLOGY and J. M. D. Coey 1506 Spatial organization of the extracellular matrix regulates See Commentary on page 1357 cell–cell junction positioning 1443 Efficient coupling of ATP hydrolysis to translocation by Qingzong Tseng, Eve Duchemin-Pelletier, Alexandre RecQ helicase Deshiere, Martial Balland, Hervé Guillou, Behzad Rad and Stephen C. Kowalczykowski Odile Filhol, and Manuel Théry

PNAS u January 31, 2012 u vol. 109 u no. 5 u v Downloaded by guest on September 24, 2021 1512 Soluble factors produced by activated CD4+ T cells 1566 BARHL2 transcription factor regulates the modulate EBV latency ipsilateral/contralateral subtype divergence in Noémi Nagy, Mónika Ádori, Abu Rasul, Frank Heuts, Daniel postmitotic dI1 neurons of the developing spinal cord Salamon, Dorina Ujvári, Harsha S. Madapura, Benjamin Qian Ding, Pushkar S. Joshi, Zheng-hua Xie, Leveau, George Klein, and Eva Klein Mengqing Xiang, and Lin Gan

1518 Mitochondrial hexokinase II (HKII) and phosphoprotein 1572 Transcriptional interpretation of the EGF receptor enriched in astrocytes (PEA15) form a molecular switch signaling gradient governing cellular fate depending on the metabolic state Alisa Fuchs, Lily S. Cheung, Enrica Charbonnier, Philipp Mergenthaler, Anja Kahl, Anne Kamitz, Vincent van Stanislav Y. Shvartsman, and George Pyrowolakis Laak, Katharina Stohlmann, Susanne Thomsen, Heiko Klawitter, Ingo Przesdzing, Lars Neeb, Dorette Freyer, 1578 Homeobox gene distal-less is required for neuronal Josef Priller, Tony J. Collins, Dirk Megow, Ulrich Dirnagl, differentiation and neurite outgrowth in the Drosophila David W. Andrews, and Andreas Meisel olfactory system Jessica Plavicki, Sara Mader, Eric Pueschel, Patrick Peebles, 1524 Cytoskeletal protein filamin A is a nucleolar protein that and Grace Boekhoff-Falk suppresses ribosomal RNA gene transcription Wensheng Deng, Cesar Lopez-Camacho, Jen-Yang Tang, Daniel Mendoza-Villanueva, Apolinar Maya-Mendoza, EVOLUTION Dean A. Jackson, and Paul Shore 1584 Carnivorous dinocephalian from the Middle Permian of Brazil and tetrapod dispersal in Pangaea 1530 Brush border Myosin Ia has tumor suppressor activity in Juan Carlos Cisneros, Fernando Abdala, Saniye the intestine Atayman-Güven, Bruce S. Rubidge, A. M. Celâl Sxengör, Rocco Mazzolini, Higinio Dopeso, Silvia Mateo-Lozano, and Cesar L. Schultz Wakam Chang, Paulo Rodrigues, Sarah Bazzocco, Hafid Alazzouzi, Stefania Landolfi, Javier Hernández-Losa, Elena 1589 Exceptionally preserved crustaceans from western Andretta, Pia Alhopuro, Eloy Espín, Manel Armengol, Josep Canada reveal a cryptic Cambrian radiation Tabernero, Santiago Ramón y Cajal, Matthias Kloor, Thomas H. P. Harvey, Maria I. Vélez, Johannes Gebert, John M. Mariadason, Simo Schwartz, Jr., and Nicholas J. Butterfield Lauri A. Aaltonen, Mark S. Mooseker, and Diego Arango 1595 Experimental evolution of multicellularity 1536 Plasma membrane recruitment and activation of the AGC William C. Ratcliff, R. Ford Denison, Mark Borrello, kinase Ypk1 is mediated by target of rapamycin complex and Michael Travisano 2 (TORC2) and its effector proteins Slm1 and Slm2 Brad J. Niles, Huzefa Mogri, Andrew Hill, 1601 Evolution of CpG island promoter function underlies Ariadne Vlahakis, and Ted Powers changes in KChIP2 potassium channel subunit gene expression in mammalian heart 1542 Nematode sperm maturation triggered by protease Qinghong Yan, Rajeev Masson, Yi Ren, Barbara Rosati, involves sperm-secreted serine protease and David McKinnon inhibitor (Serpin) Yanmei Zhao, Wei Sun, Pan Zhang, Hao Chi, Mei-Jun Zhang, Chun-Qing Song, Xuan Ma, Yunlong Shang, Bin IMMUNOLOGY Wang, Youqiao Hu, Zhiqi Hao, Andreas F. Hühmer, 1607 Polyfunctional responses by human T cells result from ’ Fanxia Meng, Steven W. L Hernault, Si-Min He, sequential release of cytokines Meng-Qiu Dong, and Long Miao Qing Han, Neda Bagheri, Elizabeth M. Bradshaw, David A. Hafler, Douglas A. Lauffenburger, and J. Christopher Love See Commentary on page 1359 DEVELOPMENTAL BIOLOGY 1548 Synthetic in vivo validation of gene network circuitry 1613 Complementary costimulation of human T-cell Sagar S. Damle and Eric H. Davidson subpopulations by cluster of differentiation 28 (CD28) and CD81 1554 Transcription factor WRKY23 assists auxin distribution Yael Sagi, Angela Landrigan, Ronald Levy, patterns during Arabidopsis root development through and Shoshana Levy local control on flavonol biosynthesis Wim Grunewald, Ive De Smet, Daniel R. Lewis, Christian 1619 Toll-like receptor 5 (TLR5), IL-1β secretion, and Löfke, Leentje Jansen, Geert Goeminne, Robin Vanden asparagine endopeptidase are critical factors for Bossche, Mansour Karimi, Bert De Rybel, Bartel Vanholme, alveolar macrophage phagocytosis and bacterial killing Thomas Teichmann, Wout Boerjan, Marc C. E. Van Montagu, Delphyne Descamps, Mathieu Le Gars, Viviane Balloy, Diane Godelieve Gheysen, Gloria K. Muday, Jirí Friml, Barbier, Sophia Maschalidi, Mira Tohme, Michel Chignard, and Tom Beeckman Reuben Ramphal, Bénédicte Manoury, and Jean-Michel Sallenave 1560 Characterization of MADS-domain transcription factor complexes in Arabidopsis flower development 1625 Scaffold protein Disc large homolog 1 is required for Cezary Smaczniak, Richard G. H. Immink, Jose M. Muiño, T-cell receptor-induced activation of regulatory Robert Blanvillain, Marco Busscher, Jacqueline T-cell function Busscher-Lange, Q. D. (Peter) Dinh, Shujing Liu, Adrie H. Alexandra Zanin-Zhorov, Jiqiang Lin, Jose Scher, Sudha Westphal, Sjef Boeren, François Parcy, Lin Xu, Cristel C. Kumari, David Blair, Keli L. Hippen, Bruce R. Blazar, Carles, Gerco C. Angenent, and Kerstin Kaufmann Steven B. Abramson, Juan J. Lafaille, and Michael L. Dustin

vi u www.pnas.org Downloaded by guest on September 24, 2021 1631 Dickkopf-3, an immune modulator in peripheral CD8 MICROBIOLOGY T-cell tolerance 1691 In-feed antibiotic effects on the swine Maria Papatriantafyllou, Gerhard Moldenhauer, Julia intestinal microbiome Ludwig, Anna Tafuri, Natalio Garbi, Gorana Hollmann, Torey Looft, Timothy A. Johnson, Heather K. Allen, Günter Küblbeck, Alexandra Klevenz, Sabine Schmitt, Georg Darrell O. Bayles, David P. Alt, Robert D. Stedtfeld, Woo Jun Pougialis, Christof Niehrs, Hermann-Josef Gröne, Gunter J. Sul, Tiffany M. Stedtfeld, Benli Chai, James R. Cole, Syed A. Hämmerling, Bernd Arnold, and Thilo Oelert Hashsham, James M. Tiedje, and Thad B. Stanton

1697 Polar growth in the Alphaproteobacterial MEDICAL SCIENCES order Rhizobiales 1637 Cooperative effects of aminopeptidase N (CD13) Pamela J. B. Brown, Miguel A. de Pedro, David T. Kysela, expressed by nonmalignant and cancer cells Charles Van der Henst, Jinwoo Kim, Xavier De Bolle, within the tumor microenvironment Clay Fuqua, and Yves V. Brun Liliana Guzman-Rojas, Roberto Rangel, Ahmad Salameh, Julianna K. Edwards, Eleonora Dondossola, Yun-Gon Kim, 1702 Surface multiheme c-type cytochromes from Alan Saghatelian, Ricardo J. Giordano, Mikhail G. Kolonin, Thermincola potens and implications for respiratory Fernanda I. Staquicini, Erkki Koivunen, Richard L. Sidman, metal reduction by Gram-positive bacteria Wadih Arap, and Renata Pasqualini Hans K. Carlson, Anthony T. Iavarone, Amita Gorur, Boon Siang Yeo, Rosalie Tran, Ryan A. Melnyk, Richard A. fi 1643 Oncogene-speci c activation of tyrosine kinase Mathies, Manfred Auer, and John D. Coates networks during prostate cancer progression Justin M. Drake, Nicholas A. Graham, Tanya Stoyanova, Amir Sedghi, Andrew S. Goldstein, Houjian Cai, Daniel A. NEUROSCIENCE Smith, Hong Zhang, Evangelia Komisopoulou, Jiaoti Huang, Thomas G. Graeber, and Owen N. Witte 1388 Functional profiling of neurons through cellular neuropharmacology fl 1649 Histone deacetylases 1 and 2 regulate autophagy ux Russell W. Teichert, Nathan J. Smith, Shrinivasan and skeletal muscle homeostasis in mice Raghuraman, Doju Yoshikami, Alan R. Light, Viviana Moresi, Michele Carrer, Chad E. Grueter, Oktay F. and Baldomero M. Olivera Rifki, John M. Shelton, James A. Richardson, Rhonda Bassel-Duby, and Eric N. Olson 1419 Dissociable neural representations of reinforcement and belief prediction errors underlie strategic learning 1655 Antagonists of growth hormone-releasing hormone Lusha Zhu, Kyle E. Mathewson, and Ming Hsu inhibit growth of androgen-independent prostate cancer through inactivation of ERK and Akt kinases 1708 Reduction of dendritic spines and elevation of Ferenc G. Rick, Andrew V. Schally, Luca Szalontay, GABAergic signaling in the brains of mice Norman L. Block, Karoly Szepeshazi, Mehrdad Nadji, Marta treated with an estrogen receptor β ligand Zarandi, Florian Hohla, Stefan Buchholz, and Stephan Seitz Xin-jie Tan, Yu-bing Dai, Wan-fu Wu, Hyun-Jin Kim, 1661 Mitochondrial dysfunction and Purkinje cell loss in Rodrigo P. A. Barros, Timothy I. Richardson, Benjamin C. autosomal recessive spastic ataxia of Yaden, Margaret Warner, David L. McKinzie, Venkatesh Charlevoix-Saguenay (ARSACS) Krishnan, and Jan-Åke Gustafsson Martine Girard, Roxanne Larivière, David A. Parfitt, β Emily C. Deane, Rebecca Gaudet, Nadya Nossova, Francois 1713 3 -Methoxy-pregnenolone (MAP4343) as an innovative Blondeau, George Prenosil, Esmeralda G. M. Vermeulen, therapeutic approach for depressive disorders Michael R. Duchen, Andrea Richter, Eric A. Shoubridge, Massimiliano Bianchi and Etienne-Emile Baulieu Kalle Gehring, R. Anne McKinney, Bernard Brais, J. Paul Chapple, and Peter S. McPherson 1719 Striatum processes reward differently in adolescents versus adults 1667 Glycerolipid signals alter mTOR complex 2 (mTORC2) to David A. Sturman and Bita Moghaddam diminish insulin signaling Chongben Zhang, Angela A. Wendel, Matthew R. Keogh, 1725 Phosphatidylinositol 4-phosphate 5-kinase alpha (PIPKα) Thurl E. Harris, Jie Chen, and Rosalind A. Coleman regulates neuronal microtubule depolymerase kinesin, KIF2A and suppresses elongation of axon branches 1673 IL-33 is processed into mature bioactive forms by Yasuko Noda, Shinsuke Niwa, Noriko Homma, Hiroyuki neutrophil elastase and cathepsin G Fukuda, Shinobu Imajo-Ohmi, and Nobutaka Hirokawa Emma Lefrançais, Stephane Roga, Violette Gautier, Anne Gonzalez-de-Peredo, Bernard Monsarrat, 1731 Spatiotemporal dynamics of neocortical excitation and Jean-Philippe Girard, and Corinne Cayrol inhibition during human sleep 1679 Syndecan-4 proteoliposomes enhance fibroblast growth Adrien Peyrache, Nima Dehghani, Emad N. Eskandar, factor-2 (FGF-2)–induced proliferation, migration, and Joseph R. Madsen, William S. Anderson, Jacob A. Donoghue, neovascularization of ischemic muscle Leigh R. Hochberg, Eric Halgren, Sydney S. Cash, Eugene Jang, Hassan Albadawi, Michael T. Watkins, and Alain Destexhe Elazer R. Edelman, and Aaron B. Baker 1737 Aβ neurotoxicity depends on interactions between 1685 Using targeted transgenic reporter mice to study copper ions, prion protein, and promoter-specific p53 transcriptional activity N-methyl-D-aspartate receptors Amanda M. Goh, Chin Yan Lim, Poh Cheang Chiam, Haitao You, Shigeki Tsutsui, Shahid Hameed, Thomas J. Ling Li, Michael B. Mann, Karen M. Mann, Kannanayakal, Lina Chen, Peng Xia, Jordan D. T. Engbers, Sergio Menendez, and David P. Lane Stuart A. Lipton, Peter K. Stys, and Gerald W. Zamponi

PNAS u January 31, 2012 u vol. 109 u no. 5 u vii Downloaded by guest on September 24, 2021 PHYSIOLOGY 1790 MicroRNA regulation of plant innate immune receptors 1743 Telomere length in early life predicts lifespan Feng Li, Daniela Pignatta, Claire Bendix, Jacob O. Brunkard, Britt J. Heidinger, Jonathan D. Blount, Winnie Boner, Megan M. Cohn, Jeffery Tung, Haoyu Sun, Pavan Kumar, Kate Griffiths, Neil B. Metcalfe, and Pat Monaghan and Barbara Baker

2+ 1749 Ca signaling amplification by oligomerization of PSYCHOLOGICAL AND COGNITIVE SCIENCES L-type Ca 1.2 channels v 1796 Retinotopic memory is more precise than Rose E. Dixon, Can Yuan, Edward P. Cheng, spatiotopic memory Manuel F. Navedo, and Luis F. Santana Julie D. Golomb and Nancy Kanwisher

PLANT BIOLOGY SYSTEMS BIOLOGY 1755 Preceramic maize from Paredones and Huaca Prieta, Peru 1802 Noninvasive inference of the molecular chemotactic Alexander Grobman, Duccio Bonavia, Tom D. Dillehay, response using bacterial trajectories Dolores R. Piperno, José Iriarte, and Irene Holst Jean-Baptiste Masson, Guillaume Voisinne, Jerome Wong-Ng, Antonio Celani, and Massimo Vergassola 1760 CLE-like (CLEL) peptides control the pattern of root growth and lateral root development in Arabidopsis Ling Meng, Bob B. Buchanan, Lewis J. Feldman, and Sheng Luan CORRECTION 1766 MtPAR MYB transcription factor acts as an on switch for proanthocyanidin biosynthesis in Medicago truncatula PSYCHOLOGICAL AND COGNITIVE SCIENCES, GENETICS Jerome Verdier, Jian Zhao, Ivone Torres-Jerez, Shujun Ge, 1808 Thin-slicing study of the oxytocin receptor (OXTR) Chenggang Liu, Xianzhi He, Kirankumar S. Mysore, gene and the evaluation and expression of the Richard A. Dixon, and Michael K. Udvardi prosocial disposition Aleksandr Kogan, Laura R. Saslow, Emily A. Impett, 1772 A polymer of caffeyl alcohol in plant seeds Christopher Oveis, Dacher Keltner, Fang Chen, Yuki Tobimatsu, Daphna Havkin-Frenkel, and Sarina Rodrigues Saturn Richard A. Dixon, and John Ralph 1778 Isoprenoid biosynthesis is required for miRNA function and affects membrane association of ARGONAUTE 1 RETRACTION in Arabidopsis Peter Brodersen, Lali Sakvarelidze-Achard, Hubert Schaller, Mehdi Khafif, Grégory Schott, Abdelhafid Bendahmane, PHARMACOLOGY and Olivier Voinnet 1808 Structural basis for nucleotide exchange on Gαi subunits fi 1784 Qa-SNAREs localized to the trans-Golgi network and receptor coupling speci city regulate multiple transport pathways and Christopher A. Johnston and David P. Siderovski extracellular disease resistance in plants Tomohiro Uemura, Hyeran Kim, Chieko Saito, Kazuo Ebine, Takashi Ueda, Paul Schulze-Lefert, and Akihiko Nakano ix Subscription Form

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