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Paola Bisignano Paola Bisignano Postdoctoral researcher Cardiovascular Research Institute University of California in San Francisco 555 Mission Bay Blvd South, MC 3122 San Francisco, CA 94143 [email protected] EDUCATION 2010 – 2013 PhD, Drug Discovery, Istituto Italiano di Tecnologia and Università degli Studi di Genova, Italy. 2006 – 2008 MSc, Cellular and Molecular Biology, Università degli Studi di Genova, Italy, magna cum laude. 2001 – 2005 BSc, Biological Sciences, Università degli Studi di Genova, Italy, magna cum laude. POSITIONS 2015 – present Postdoctoral research, University of California, San Francisco Advisor: Michael Grabe, Cardiovascular Research Institute, Pharmaceutical Chemistry • structure-based drug design for sodium glucose symporters • homology modelling, molecular dynamics simulation, Markov State Modelling 2014 – 2015 Postdoctoral research, Ichan School of Medicine, Mount Sinai, New York Advisor: Marta Filizola, Structural and Chemical Biology • structure-based and ligand-based drug design for GPCR • virtual screening, chemoinformatics. 2013 Temporary research, Istituto Italiano di Tecnologia, Genova, Italy Advisor: Andrea Cavalli, Drug Discovery and Development • in silico multi-target in Alzheimer’s disease • virtual screening, free energy calculations RESEARCH TRAINING 2012 – 2013 Visiting PhD student, Barcelona Biomedical Research Park, Barcelona, Spain Advisor: Gianni de Fabritiis, Multiscale Laboratory • free energy of protein ligand binding on pharmaceutically relevant targets • molecular dynamics simulation, Markov State Modelling 2010 – 2013 PhD student, Istituto Italiano di Tecnologia, Genova, Italy Advisors: Andrea Cavalli & Angelo Favia, Drug Discovery and Development • in silico fragment-based drug design • virtual screening, molecular dynamics simulation, free energy calculations 2009 – 2010 Bioinformatics Technician, San Martino Hospital, Genova, Italy Advisor: Domenico Bordo, Department of Bioinformatics and Structural Biology • protein ligand binding interactions, biochemical pathways, neuroblastoma • bioinformatics, microarrays data analysis, teaching assistant 2007 – 2008 Undergraduate Research, National Research Council, Genova, Italy Advisor: Oscar Moran, Institute of Biophysics • modelling of cystic fibrosis transmembrane conductance regulator • homology modeling, docking, molecular dynamics simulations, bioinformatics 2006 – 2007 Undergraduate Research, Università degli Studi di Genova, Genova, Italy Advisor: Paola Manduca, Laboratory of Genetics • mechanism of metastasis in bone cells 2004 – 2005 Undergraduate Research, Università degli Studi di Genova, Genova, Italy Advisor: Laura Vergani, Laboratory of Physiology. • gene identifications in Mitilus galloprovincialis MENTORING ACTIVITIES 2014 Supervision of a PhD student and two undergraduates, Ichan School of Medicine, New York, USA. 2013 Supervision of a PhD student, Istituto Italiano di Technologia, Genova, Italy. AWARDS and FELLOWSHIPS 2010 – 2012 PhD Fellowship from the Università degli Studi di Genova, Genova, Italy. 2006 Scholarship received from the Università degli Studi di Milano-Bicocca, Milano, Italy. 2002 Scholarship received from the Università degli Studi di Genova, Genova, Italy. PROFESSIONAL MEMBERSHIP 2014 – present Biophysical Society (BPS) PUBLICATIONS 1. Di Martino R., De Simone A., Andrisano V. Bisignano, P., Bisi A., Gobbi S., Rampa A., Fato R., Bergamini C., Perez D., Martínez A., Bottegoni G., Cavalli A., and Belluti F. The Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors. 2015 J. Med. Chem. 2. Bottegoni G., Veronesi M., Bisignano P., Kacker P., Favia A. D. and Cavalli A. Development and Application of a Virtual Screening Protocol for the Identification of Multitarget Fragments. 2015 ChemMedChem. 3. Bisignano P., Burford N.T., Shang Y., Marlow B., Livingston K., Fenton A.M., Rockwell K., Budenholzer L., Traynor J. R., Gerritz S.W., Alt A. and Filizola M. Structure-Guided Discovery of Positive Allosteric Modulators of the mu-Opioid Receptor. 2015 J. Chem. Inf. Model. 55(9):1836-1843 4. Prati F., De Simone A., Bisignano P., Armirotti A., Summa M., Pizzirani D., Scarpelli R., Andrisano V., Perez-Catillo A., Monti B., Massenzio F., Polito L., Racchi M., Favia A. D., Bottegoni G., Martinez A., Bolognesi M. L. and Cavalli A. Multitarget drug discovery for Alzheimer's Disease: triazinones as the first dual BACE-1/GSK-3β fragment hits. 2015 Angewandte Chemie 54(5):1578-1582. 5. Shang Y., LeRouzic V., Schneider S., Bisignano P., Pasternak G.W., and Filizola M. Mechanicistic Insights into the allosteric modulation of opioid receptors by sodium ions. 2014 Biochemistry 53(31):5140-5149. 6. Bisignano P., Doerr S., Harvey M., Favia A. D., Cavalli A. and de Fabritiis G. Kinetic characterization of binding in AmpC β-lactamase by high-throughput MD simulations. 2014 J. Chem. Inf. Model. 54(2):362-366. 7. Gallina A. M., Bisignano P., Bergamino M. and Bordo D. PLI: a web server for the comparison of protein-ligand interactions observed in PDB structures. 2013 Bioinformatics 29(3):395-397. 8. Bisignano P., Lambruschini C., Bicego M., Murino V., Cavalli A. and Favia A.D. In silico deconstruction of ATP competitive inhibitors of Glycogen Synthase Kinase-3β. 2012 J. Chem. Inf. Model. 52(12):3233-3244. 9. Favia, A. D., Bottegoni, G., Nobeli, I., Bisignano, P. and Cavalli, A. SERAPhiC: a Benchmark for in Silico Fragment-Based Drug Design. 2011 J. Chem. Inf. Model. 51(11):2882-2896. 10. Bisignano, P. and Moran, O. Molecular dynamics analysis of the wild type and dF508 mutant structures of the human CFTR-nucleotide binding domain 1. 2010 Biochimie 92:51-57. CONFERENCE PROCEEDINGS 1. Prati F., De Simone A., Bisignano P., Bottegoni G., Bolognesi M. L., and Cavalli A., Structure- Based design and synthesis of novel BACE-1/GSK-3β dual inhibitors. Proceeding of the 8th Annual Drug Discovery for Neurodegeneration Conference: An Intensive Course on Translating Research into Drugs, Miami, FL, 2014. 2. Bicego M., Favia A. D., Bisignano, P, Cavalli, A., and Murino, V. An innovative protocol for comparing protein binding site via atomic grid maps. Proceeding of International Conference on Knowledge Discovery and Information Retrieval 2011, 413-422. SELECTED CONTRIBUTION AT CONFERENCES ORAL PRESENTATIONS 1. In silico Fragment Based Drug Design by high-throughput Molecular Dynamics. MD Retreat, October 18-19, 2012 Les Avellanes Monastery, Noguera, Lleida, Spain. 2. In silico deconstruction of ATP-competitive inhibitors of Glycogen Synthase Kinase-3β. Selected young scientist at Chem4life, January 18, 2012, CBA, Genova, Italy. POSTER PRESENTATIONS 1. Bisignano P., Kalyanaraman C., Wright E., Abramson J., Jacobson M., and Grabe M. Structure- based drug design for sodium-dependent glucose transporters. Biophysical Society, 60th Annual Meeting, February 27-March 2, 2016, Los Angeles, USA. (to be given) 2. Bisignano P., Burford N.T., Rockwell K., Budenholzer L., Gerritz S.W., Alt A. and Filizola M. Structure-Guided Discovery of Positive Allosteric Modulators of the mu-Opioid Receptor. Biophysical Society, 59th Annual Meeting, February 7-11, 2015, Baltimore, USA. 3. Bisignano P., Favia A.D., Masetti M. and Cavalli A. In silico deconstruction of ATP-competitive inhibitors of Glycogen Synthase Kinase-3β. Computationally Driven Drug Design, November 21- 23, 2011, L’Aquila, Italy. 4. Bisignano P., Favia A.D., Masetti M. and Cavalli A. In silico deconstruction of ATP-competitive inhibitors of Glycogen Synthase Kinase-3β.5th Theoretical Biophysics International Symposium, June 8-12, 2011, Madeira, Portugal. 5. Bisignano P., Favia A.D., Masetti M. and Cavalli A. In silico deconstruction of ATP-competitive inhibitors of Glycogen Synthase Kinase-3β. New Therapies for Inflammation, September, 24, 2010, Genova, Italy. 6. Bisignano P. and Moran O. Molecular Dynamics of CFTR: structural stability and thermodynamics of the first nucleotide binding domain (NBD1). Proceeding of the Sixth Annual Meeting of the Bioinformatics Italian Society BITS09, March 18-20, 2009, Genova, Italy. INVITED TALKS 2015 Cardiovascular Research Institute, University of California San Francisco, San Francisco, USA. 2013 Chemical and Structural Biology Laboratory, Mount Sinai Ichan School of Medicine, New York, USA. 2013 Biophysics Institute, National Research Council, Genova, Italy. 2013 Laboratory of Computational Medicine, School of Medicine, Universitat Autònoma de Barcelona, Spain. LANGUAGES 1. Italian: Native language. 2. English: Bilingual proficiency - spoken and written. 3. Spanish: Intermediate proficiency - spoken and written. PROFESSIONAL REFERENCES Prof. M. Grabe Dr. A. D. Favia Prof. A. Cavalli ([email protected]) ([email protected]) ([email protected]) Associate Professor Cardiovascular Principal Scientist II, Lilly China Head of Computational Chemistry, Research Institute, University of R&D Center, Building 8, Pudong, D3 Department, Istituto Italiano di California San Francisco, San Shanghai, CN. Tecnologia, Genoa, IT. Francisco, CA, US. Landline: +1 415-502-2874 Landline: +86 2120805557 Landline: +39 01071781530; +39 0512099735 .
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