H. Weinstein, CV Revised - 5/2015 Page 1 of 25 Name: HAREL WEINSTEIN

Nationality: USA

Office Address: Weill Medical College of Cornell University Tel.# 212-746-6358 Department of Physiology and Biophysics, Box 75 E-mail: [email protected] 1300 York Avenue, Room E-509 Fax # 212-746-8690 New York, NY 10021

Home Address: 151 West 86th Street, APT 3C New York, NY 10024-3401

Education: Technion-Israel Institute of Technology 1966, B.Sc. (Chemistry), Haifa, Israel

Graduate School of the Technion-IIT 1968, M.Sc. (Quantum Chemistry) Haifa, Israel

Graduate School of the Technion-IIT 1971, D.Sc. (Theoret. Phys. Chem.)

Mount Sinai School of Medicine Medical Curriculum

Postdoctoral Training: 1973-1974 Associate Research Scientist, Chemistry, The Johns Hopkins University (with Robert G. Parr)

Positions and Appointments: 1968-1971 Senior Research Assistant, Chemistry, Technion, IIT 1971-1973 Lecturer, Chemistry, Technion, IIT 2-4/74, 3-5/75 Visiting Scientist, Genetics, Stanford University School of Medicine 1974-1976 Assistant Professor of Pharmacology, Mount Sinai School of Medicine 1976-1979 Associate Professor of Pharmacology, Mount Sinai School of Medicine 1979-2002 Professor of Pharmacology, Mount Sinai School of Medicine 1985-2002 Professor and Chairman, Physiology and Biophysics, Mount Sinai School of Medicine 1998-2002 Dr. Harold and Golden Lamport Professor of Physiology and Biophysics, Mount Sinai School of Medicine 1999-2002 Director, Institute for Computational Biomedicine, Mount Sinai School of Medicine 2002-present Maxwell M. Upson Professor and Chairman, Physiology and Biophysics, Weill Cornell Medical College, Cornell University 2002-present Chair, Graduate Program in Physiology, Biophysics and Systems Biology, Weill Graduate School of Medical Sciences, Weill Cornell Medical College, Cornell University 2002-present Director, Institute for Computational Biomedicine, Weill Cornell Medical College, Cornell University 2002-present Tri-Institutional Professor: Rockefeller University, Sloan Kettering Institute, Cornell University

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Scientific and Medical Societies: American Society for Pharmacology and Experimental Therapeutics; American Physiological Society; American Chemical Society; Biophysical Society; New York Academy of Sciences; The Harvey Society; International Society for Quantum Biology and Pharmacology; American Association for the Advancement of Science; Sigma Xi. International Society for Computational Biology

Honors and Awards: 1978-82 Irma T. Hirschl Trust Career Scientist Award 1979-84, 1984-89 ADAMHA-NIDA Research Scientist Development Award (K02) 1990-2001 (compet. renew 2002-2007) NIH-NIDA Senior Research Scientist Award (K05) 1982-84/1985-87 Vice President / President - International Society of Quantum Biology 1988 Award for Outstanding Contributions in Research, Intl. Soc. Quantum Biol. 1988 Parke-Davis Distinguished Lecture, Univ. of Michigan 1989/1990 Outstanding Achievement, Life and Health Sciences, IBM Supercomputing Competition 1989-1992 & 1993 Councillor & President, Assoc. Chairmen Depts. Physiology (ACDP) 1992-1993 Chair, Biophysics Section, New York Academy of Sciences 1993-2002 Science Advisory Committee, The NY Academy of Medicine 1998 Named Harold and Golden Lamport Professor of Physiology and Biophysics, Mount Sinai School of Medicine 1998 Elected: Member, Council of the Biophysical Society (1998-2002) 2002 Named: Maxwell M. Upson Professor of Physiology and Biophysics, Weill Medical College of Cornell University 2003 Council, The Harvey Society (2003-2006) 2005 President’s Lecturer, The College on Problems of Drug Dependence 2005 Perspectives Lecture, Molecular Biophysics, 5th Congress Intl Soc Theo Chemical Physics 2006 Distinguished Lecturer, 34th Leermakers Symposium, Wesleyan University. 2006 Elected, President-Elect, The Biophysical Society: President -2008, Past President 2009 2006 Elected, Board of Directors, International Society for Computational Biology 2010 Elected, Board of Directors, Winifred Masterson Burke Medical Research Institute, NY 2010 Elected, Member and ISCB representative on the Research Information Technology Subcommittee of FASEB Science Policy Committee 2011 New and Notable Lecture, 55th Biophysical Society Meeting 2012 Keynote Lecture, 19th EuroQSAR conference on Knowledge Enabled Ligand Design conference in Vienna, Austria. 2013 Invited Plenary Lecture, 59th Benzon Symposium on Membrane proteins: Structure, Function, and Dynamics – Copenhagen, DK 2014 Drs. Gabor and Harriette Kaley Endowed Lecturer, New York Medical College, Valhalla, NY.

Other Academic Activities and Experience: 1979-1983 Member, Drug Abuse Biomedical Research Review Committee (Study Section), National Institute on Drug Abuse (NIDA) 1979-1981 Consultant, Merck Sharp and Dohme Laboratories, USA. 1981 Consultant, Drug Science Foundation, Medical College of South Carolina 1986 Consultant, The Upjohn Company, Kalamazoo, Mich. 1985-1986 Member, PROPHET Computer Resource Advisory Panel, NIH-DRR 1988 Member, Supercomputer Evaluation Panel, Office of the Director-NIH. 1975,1979,1983,1992 Member of Technical Review Panels for NIDA-NIH

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H. Weinstein, CV Revised - 5/2015 Page 3 of 25 1977-1995 Editorial and Advisory Board of MOLECULAR PHARMACOLOGY 1986-1993 Editorial Board of ENZYME 1989-1991 Editor–in–Chief (with G. Naray-Szabo) of REPORTS IN MOL. THEORY 1990-2000 Editorial Board of MOLECULAR ENGINEERING (Coordinating Editor) 1991-present Editorial Board of ADVANCES IN QUANTUM CHEMISTRY 1992-2001 Editorial Board of INTL. JOURNAL OF QUANTUM CHEMISTRY 1991 Consultant, Abbott Laboratories, Chicago, Ill. 1991, 1993 Consultant, Neurogenetic Corp. (Synaptic), Paramus, NJ. 1992 Consultant, Pfizer, Inc. Central Research, CT. 1992-1993 Consultant, Burrows-Wellcome, NC. 1993-2003 Science Advisory Board, TELIK, Inc. (Terrapin Technol., Inc. ), South SF 1999-2004 Science Advisory Board, NovaSite Pharmaceuticals, Inc. San Diego, CA. 2001-2008 Science Advisory Bd., Predix Pharmaceuticals (BioIT), Tel Aviv, Israel. 1998 -2004 Consultant,UCB (CytoMed) - Cambridge, MA 1982, 1986, 1988...Ad-hoc member, Board of Scientific Advisors, Division of Cancer …2000, 2002 Biochemistry and Diagnosis, NCI-NIH 1986-1994 Member, U.S. Department of Energy, Health and Environmental Research Advisory Committee 1993, 1994 Awards Panel, E.O. Lawrence Awards in Life Sciences, US Dept. Energy 1990-1993 Member, Drug Abuse Biomedical Research Review Committee (Study Section), Biochemistry Research Subcommittee, NIDA-NIH. 1997 Member (Chair Designate), Molecular, Cellular and Chemical Neurobiology Research Subcommittee, NIH-NIDA Initial Review Group (NIDA-IRG) 1998-2001 Member, Molecular, Cellular, Developmental Neurobiology (MDCN-3) Study Section, NIH. 1999-2003 Member, Scientific Advisory Council of CERCA -Center for Research in Applied Computation, Montreal, CANADA 1999-2002 Member and Secretary, Board of Directors, NY Structural Biology Center 1999-present Member, Scientific Advisory Board – Inst. for the Study of Aging, NYC. 2001-2004 Member, Board of Directors, Haddassah Medical Organization. 2001-2007 Member, National Allocations Review Panel, NCSA/NPACI Supercomputer Centers 2001 Member, NIH-NSF Panel on Assessing Bioengineering&Bioinformatics Research Training, Education and Career Development 2001-present Member, Publications Committee, International Society for Computational Biology, 2003-2009 Editorial Board of JOURNAL OF MEDICINAL CHEMISTRY 2004-2008 Member, TechConnect Advisory Committee, Microsoft/CTC 2005, 2006, 2011 Member, NIH Director's Pioneer Award (NDPA) Program Review Panel 2005-2010 Member, Scientific Review Committee, Dulbecco Telethon Institute, Italy 2007-present Member, NIH Study Section: Biophysics of Neuronal Systems (BPNS) 2007-2010 Member, Board of Directors, International Society for Computational Biology 2007-2014 Member, NIH Director's New Innovator Award Program Review Panel 2008-2009 President, The Biophysical Society 2008-present Member, Public Affairs Committee, The Biophysical Society 2010-present Member, Board of Directors, Winifred Masterson Burke Medical Research Institute, Inc. 2010-2012 Chair, NIH Study Section: Biophysics of Neuronal Systems (BPNS) 2014-2018 Member, Executive Committee, Neuropharmacology Div., ASPET 2014- Member, Editorial Review Panel NIH Director's New Innovator Award Active Member - NIH Reviewer Reserve (CSR), review panels for NSF and the Canadian Research Council, The Wellcome Trust, HHMI, HFS. Reviewer for: PNAS, J. AMER. CHEM. SOC., J. PHYS. CHEM., BIOPHYS. J., NATURE, SCIENCE, CELL, 3

H. Weinstein, CV Revised - 5/2015 Page 4 of 25 PROTEIN SCIENCE, J. MED. CHEM., PROT. ENGNG., J. THEORET. BIOL., J. BIOL. CHEM., J. PHARMACOL. EXPTL. THERAP., ENDOCRINOLOGY, COMPUT AIDED MOL. DESIGN, RECEPTORS & CHANNELS, NEUROSCIENCE Letters etc.

Teaching Experience 1966-1973 Chemistry Courses: General, Physical, Chemical Bond, Quantum Chemistry 1973 Quantum Mechanical Approaches to Drug-Receptor Interaction Studies (Israel Institute for Biological Research) 1975-1987 Molecular Aspects of Basic Pharmacology and Receptor Theory, In: Basic Pharmacology graduate course in Biological Sciences Program, City University of New York. 1976-1986 Physicochemical Principles of Drug Action, Receptor Theory, Pharmacokinetics, General Anesthetics, Structural Concomitants of Drug Side Effects. In: Systemic Pharmacology, Medical School Course, Mount Sinai School of Medicine 1977-1986 Conference Leader in Neurosciences and in Systemic Pharmacology Courses for medical students, Mount Sinai School of Medicine (MSSM). 1982-1985 Lecturer, Graduate Course in Neurochemistry: Receptor Theory and Classification. 1979 Co-Director of Systemic Pharmacology Course for medical students, MSSM. 1979-1984 Course Director, Graduate Course: Basic Pharmacology, Biological Sciences Doctoral Program. 1986-present Course Director, Graduate Course: Advanced Molecular Biophysics: Proteins, Nucleic Acids and Membranes. 1990-2002 Director, Graduate Course: Computational Molecular Modeling 1992 Lecturer, Grad Course: Biomolecular structure and function / Advanced Cell Biology. 1994-2002 Lecturer, Graduate Course on Signal Transduction: Structure and function of G-protein coupled receptors, G-proteins, and SH2/SH3 domains. 1998-2000 Lecturer, Graduate Course in Mechanisms of Disease and Therapy: Structure-based Design. 2001-2003 Lecturer, Core III Course, Biophysics, Structural Biology & Bioinformatics. 2003-2004 Director and Lecturer, Tri-Institutional Course in Computational Biology 2004-2012 Lecturer, Weill Graduate Course in Signal Transduction 2004-2010 Lecturer, Rockefeller Graduate Course: Seminars in Modern Biology 2006-present Lecturer (WCMC+Ithaca), Methods in Biophysics Graduate Course 2008-present Lecturer, Graduate Cell Physiology Course 2010-present Lecturer, Graduate Core Biochemistry Course

Education of Graduate Students Past and Current trainees (Partial List): Barbara J. Ebersole (Ph.D. 1985); Andrew Shenker (M.D./Ph.D. 1985); Maureen Newton (Ph.D., 1985); Robert Cory (Ph.D., 1985); Michael DeVivo (Ph.D.; 1987); Johannes P. Dijkman (Ph.D., 1989); Gustavo Mercier (M.D./Ph.D. 1989); Eric Haaksma (co-advisor, Ph.D. thesis, Univ. Amsterdam, 1990); Ron Buono (Ph.D. 1991); Beth Feller-Printz (M.D./Ph.D. 1992); Waldo Feng (M.D./Ph.D. 1993); Alan Factor (Ph.D. 1993); Daqun Zhang (Ph.D. 1994); Liisa Laakkonen (Ph.D. 1996); Juan A. Ballesteros (Ph.D. 1997); Nina Pastor (Ph.D. 1997); Karel Konvicka (Ph.D., 1999); Felicia Pitici (Ph.D. 1999); Monserrat Batlle (Ph.D. 2001); Taihao Jin (Ph.D. 2003), Jian Sun (Ph.D. 2003); Tatyana Gindin (M.D./Ph.D. 2006); Thijs Beuming (Ph.D. 2007); Josh Speidel (PhD 2007); Anshu Bhatia (MS, 2009); Matthew Diamond, (MD/PhD, 2008);Violet (Chun-Wen) Chang (PhD, 2009); Daniel Han (Ph.D., 2009); Xiaoxia Ge (Ph.D., 2010); Daniel Terry (PhD 2012); Sayan Mondal (PhD 2013); Sebastian Stolzenberg (PhD 2013); Milka Doktorova (PhD candidate), Michael LeVine (PhD candidate), Jaime Medina (PhD candidate).

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Education of Postdoctoral Students (current positions) 1974-1976 Dr. David Chou (Presently: Dir., Clinical Pathology Labs, Cleveland Clinic, Ohio) 1976-1978 Dr. Roman Osman (Presently: Professor, Mount Sinai School of Medicine) 1976-1978 Dr. W. Daniel Edwards (Presently: Assoc. Professor of Chemistry, U. of Idaho) 1978-1979 Dr. Sidney W. Topiol (Presently: Associate Director, Computational Chemistry, Lundbeck Research USA, Inc.) 1980-1982 Dr. Carol Venanzi (Presently: Distinguished Professor, Chemistry, N.J. Inst. Technol.) 1982-1985; 1987;1989 Dr. Aleksander P. Mazurek (Presently: Professor and Director, Drug Institute, Warsaw, Poland) 1984-1986 Dr. Krishnan Namboodiri (Staff Scientist, Martin Marietta) 1986-1987 Dr. Randy Zauhar (Research Associate Professor, U. Penn; Associate Professor, Chemistry & Biochemistry, University of the Sciences) 1986-1988 Dr. Kenzi Hori (Associate Professor, Dept. Chemistry, Yamaguchi University, Japan) 1988-89, 1991-92; 1993; 1996-97 Dr. Leonardo Pardo (Professor, Department of Biostatistics, School of Medicine, Autonomous University, Bellatera (Barcelona), Spain). 1990-1991 Dr. Eric Haaskma (Director of Chemistry, Boehringer-Ingelheim, Vienna, Austria) 1989-1991 Dr. Vladimir Frecer (Presently: Staff Scientist, Cancer Inst., Bratislava, Slovakia) 1989-1991 Dr. Karol Miaskiewicz (Presently: Senior Scientist, NIH-NCI Frederick Labs.) 1989-1991 Dr. Juan Luis Pascual–Ahuir (Associate Professor, Dept. Physical Chemistry, Univ. of Valencia, Spain) 1991-1995 Dr. Karen Haydock (Scientist, Inst. Protein Research, India) 1992-1994 Dr. Xincai Luo (Associate Director, Informatics, Lead Discovery Astra - Zeneca, U.S.A.) 1993-1997 Dr. Daniel Strahs (Associate Professor, Pace Univ., NYC) 1994-1997 Dr. Frank Guarnieri (Technology Leader, Sarnoff Institute) 1994-1995 Dr. Leon Xiao (Computer Networks Specialist, Consultant) 1995-1996 Dr. Nicolas Follope (Researcher, Carolinska Inst., Stockholm), 1997-1999 Dr. Tap Hua Dong (Assoc. Prof., Physics, U of Paris, Jussieux, France) 1996-1998 Dr. Ramasubbu Sankararamakrishnan (Asst. Prof., IIT, Kanpur, India) 1997-1999 Dr. Anne Lebrun (Lecturer, U of Paris, Jussieux, France France) 1997-1998 Dr. Juan A. Ballesteros (Chairman & Chief Scientific Officer, Vivia Biotech, SL, Spain) 1998-2003 Dr. Sergio Hassan (Senior Staff Scientist, the NIH) 1998-2002 Dr. Irache Visiers (Dir., Regulatory Affairs, Novartis Inst. for Biomed. Res., Inc,) 1999-2000 Dr. Fabien Campagne (Assistant Professor and Bioinformatics Officer, WCMC) 1999-2000 Dr. Benjamin B. Braunheim (Dir. Research, NeuralNets Biotech Co., NYC) 2000-2003 Dr. Xavier Periole (U. Groningen, Netherlands) 2000-2001 Dr. Osvaldo Olmea (Bioinformatics Scientist-PharmaMar Pharmaceuticals, Madrid,Spain) 2000-2001 Dr. Wen Zhang (Bioinformatics Scientist, REGENERON, NJ) 2000-2004 Dr. Marc A Ceruso (Asst. Professor, Chemistry, CUNY City College) 2000-2002 Dr. Marta Filizola (Professor (tenured), Dept Structural and Chemical Biology, Mount Sinai School of Medicine, NY) 2001-2005 Dr. Sandhya Kortagere (Assistant Professor, Drexel University) 2002-2006 Dr. Luis Gracia (Visualization Technology Engineer, ICB-WCMC, NY) 2003-2005 Dr. Xiang Simon Wang (Postdoctoral Fellow, U North Carolina, Chapel Hill) 2003-2007 Dr. Masha Niv (Senior Lecturer, Hebrew University, Jerusalem) 2003-2005 Dr. Nathalie Basdevant (Lecturer, University of Paris III, Jussieu, France) 2004-2009 Dr. Zeynep Gumus (Assistant Professor, Mount Sinai School of Medicine, NY) 2004-2011 Dr. Jian Sun (Associated Research Scientist, WCMC) 2005-2007 Dr. Melih Sener (Research Associate, Physics, University of Illinois)

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H. Weinstein, CV Revised - 5/2015 Page 6 of 25 2005-2010 Dr. George Khelashvili (Instructor, P&B and ICB, WCMC) 2007-2011 Dr. Spencer Eriksen (Zinc Finger Core Dir., U. Michigan) 2007-2009 Dr. Irina Moreira (Professorial Investigator, University of Porto, Portugal) 2007-2009 Dr. Thijs Beuming (Senior Applications Scientist, Schroedinger, Inc., NYC) 2007-2011 Dr. Jufang Shan (Applications Scientist, Schroedinger, Inc., NYC) 2007-2009 Dr. Joseph Stember (Medical Student, NYU) 2010-2012 Dr. Pedro Blecua (Research Scientist, MSKCC) 2011-2014 Dr. Michelle Sahai (Assistant Prof., Roehampton College, London, UK) 2011-2013 Dr. Niklaus Johner (Research Scientist, The Brain Project, Lausanne, Switzerland) 2012- Dr. Jose Manuel Perez-Aguilar 2012-2014 Dr. Jerez Te (Scientist, DoD Biotechnology High Performance Computing Software Applications Institute) 2012-2014 Dr. Ozge Sensoy (Assistant Professor, School of Engineering and Natural Sciences, Medipol University, Istanbul, Turkey). 2013-2014 Dr. Sayan Mondal (Applications Scientist, Schroedinger, Inc., NYC) 2015- Dr. Zhenlong Li

MAJOR INSTITUTIONAL COMMITTEES at Weill CORNELL Medical College Research Planning Committee Executive Committee of the Graduate School Science Planning Committee Search Committee Othorhinolaryngology Chair Committee of Review Neuroscience Recruitment Committee Executive Faculty Council Structural Biology Recruitment Committee General Faculty Council Strategic Plan III Research Committee Budget Restructuring Committee Awards Committee (Chair)

PATENTS: 1)Peptides and other small molecules derived from regions of interacting proteins and uses thereof Ravi Iyengar, Geshi Weng, Yibang Chen, Harel Weinstein, Elizabeth Buck. US Patent #6,555,522: 4/29/2003; 2) T1r3 a novel taste receptor. Robert Margolskee, Marianna Max, Harel Weinstein, Fabien Campagne, Gopi Y. Shanker. US Patent #20040219632 11/04/2004; Europe Patent 02734026.4-2405-US0212656.

Publications: Citations for 'harel weinstein' : 15,462; i-Index: 299; h-Index: 65 (Google Scholar 5-15-2015)

B. Reviews, Symposia and Books B1. Weinstein, H., Pauncz, R. and Cohen, M. - Localized molecular orbitals Ch III In: Advances in Atomic and Molecular Physics, Vol. 7, eds. I. Esterman and R.D. Bates, Academic Press, New York, 1971, pp. 97-140. B2. Weinstein, H., Apfelderfer, B., Cohen, S., Maayani, S. and Sokolovsky, M.-Molecular orbital study of the conformation of acetylcholine-like molecules. In: The Conformation of Biological Molecules and Polymers - The 5th Jerusalem Symposium, eds. E.D. Bergmann and B. Pullman, Academic Press, New York, 1972, pp. 531-543. B3. Halevi, E.A., Pauncz, R., Schek, I. and Weinstein, H. - Multiplicity changes during thermal dissociation. In: Chemical and Biochemical Reactivity, eds. E.D. Bergmann and B. Pullman, D. Reidel, Dordrecht/ Boston, 1974, pp. 167-182. B4. Weinstein, H., Srebrenik, S., Pauncz, R., Maayani, S., Cohen, S. and Sokolovsky, M. - Characterization of drug-receptor interactions in cholinergic systems by molecular interaction potentials. In: Chemical and Biochemical Reactivity, eds. E.D. Bergmann and B. Pullman, D. Reidel, Dordrecht/Boston, 1974, pp. 493-512. 6

H. Weinstein, CV Revised - 5/2015 Page 7 of 25 B5. Loew, G., Berkowitz, D., Weinstein, H. and Srebrenik, S. - Quantum chemical studies of morphine-like opiate narcotics: effect of polar group variations. In: Molecular and Quantum Pharmacology , eds. E.D. Bergmann and B. Pullman, D. Reidel Publishing Co., Dordrecht-Holland/Boston, 1974, pp. 355-389. B6. Loew, G., Weinstein, H. and Berkowitz, D. - Theoretical study of the solvent effect on ionization and partition behavior of related opiate narcotics: hydromorphone and oxymorphone. In: Environmental Effects on Molecular Structure and Properties, ed. B. Pullman, D. Reidel Publ. Co., Dordrecht-Holland/Boston, 1976, pp. 239-258. B7. Green, J.P., Johnson, C.L. and Weinstein, H. - Histamine as a neurotransmitter. In: Psychopharmacology - A generation of progress, eds. M. Lipton, A. DiMascio and K. Killam, Raven Press, New York, 1977, pp. 319-332. B8. Green, J.P., Johnson, C.L., Weinstein, H., Kang, S. and Chou, D. -Molecular determinants for interaction with the LSD receptor: biological studies and quantum chemical analysis. In: The Psychopharmacology of Hallucinogens, eds. R.E. Willette and R.C. Stillman, Pergamon Press, 1978, pp. 28-60. B9. Green, J.P., Johnson, C.L. and Weinstein, H. - Histamine activation of adenylate cyclase in brain: an H2- receptor and its blockade by LSD. In: Histamine Receptors, ed. T.O. Yellin, Spectrum Publications 1978, pp. 185-210. B10. Maayani, S. and Weinstein, H. - Some structure activity relationships of phencyclidine derivatives as anticholinergic agents in vitro and in vivo. In: Membrane Mechanisms of Drugs of Abuse, eds. C. Wm. Sharp and L. Abood, Allan R. Liss Publ., New York, 1979, pp. 91-106. B11. Green, J.P., Weinstein, H. and Maayani, S. - Defining the histamine H2-receptor in brain: the interaction with LSD. In: QuaSAR, Quantitative Structure Activity Relationships of Analgesics, Narcotic Antagonists, and Hallucinogens, NIDA Research Monograph 22 ed. G. Barnett, M. Trsic, and R.E. Willette (U.S. Government Printing Office), 1978, pp. 38-59. B12. Weinstein, H., Green, J.P., Osman, R. and Edwards, W.D. - Recognition and activation mechanisms on the LSD/serotonin receptor: the molecular basis of structure activity relationships. In: QuaSAR, Quantitative Structure Activity Relationships of Analgesics, Narcotic Antagonists, and Hallucinogens, NIDA Monograph 22, ed. G. Barnett, M. Trsic and R.E. Willette (U.S. Government Printing Office), 1978, pp. 333-358. B13. Osman, R., Weinstein, H. and Green, J.P. - Parameters and methods in quantitative structure-activity relationships. In: Computer-Assisted Drug Design. ACS Symposium Series 112, ed. E.O. Olson and R.E. Christoffersen (American Chemical Society, Washington, D.C.), 1979, pp. 21-77. B14. Weinstein, H., Osman, R. and Green, J.P. - The molecular basis of structure-activity relationships: quantum chemical recognition mechanisms in drug-receptor interactions. In: Computer-Assisted Drug Design. ACS Symposium Series 112, ed. E.O. Olson and R.E. Christoffersen (American Chemical Society, Washington, D.C.), 1979, pp. 161-187. B15. Hough, L.B., Weinstein, H. and Green, J.P. - One agonist and two receptors mediating the same effect: histamine receptors linked to adenylate cyclase in brain. In: Receptors for Neurotransmitters and Peptide Hormones , ed. G. Pepeu, M.J. Kuhar, and S.J. Enna (Raven, New York), 1980, pp. 183-192. B16. Weinstein, H., Maayani, S., Glick, S.D. and Meibach, R.C. - Integrated studies on the biochemical, behavioral and molecular pharmacology of phencyclidine - A progress report. In: PCP (Phencyclidine): Historical and Current Perspectives. ed. E.F. Domino (NPP Books, Ann Arbor, Michigan), 1981, pp. 131-175. B17. Weinstein, H. and Green, J.P., (eds) -Quantum Chemistry in Biomedical Sciences. Ann. N.Y. Acad. Sci. 1981 , Vol. 367, 552 pp. B18. Weinstein, H., Osman, R., Green, J.P. and Topiol, S. - Electrostatic potentials as descriptors of molecular reactivity: The basis for some successful predictions of Pbiological activity. In: "Chemical Applications of Atomic and Molecular Electrostatic Potentials, " eds. P. Politzer and D.G. Truhlar (Plenum Press, N.Y.) 1981, pp. 309-323. B19. Weinstein, H., Osman, R., Topiol, S. and Green, J.P. - Quantum chemical studies on molecular determinants of drug action. Ann. N.Y. Acad. Sci. 1981, 367:434-451.

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H. Weinstein, CV Revised - 5/2015 Page 8 of 25 B20. Topiol, S., Osman, R. and Weinstein, H. - Effective potential methods for use in electronic structure calculations of large molecules. Ann. N.Y. Acad. Sci. 1981 , 367:17-34. B21. Osman, R., Weinstein, H. and Topiol, S. - Models for active sites of metalloenzymes. II. Interactions with a model substrate. Ann. N.Y. Acad. Sci., 1981 , 367:356-369. B22. Weinstein, H., Topiol, S. and Osman, R. - On the relation between charge redistribution and intermolecular forces in models for molecular interactions in biology. In: Intermolecular Forces, B. Pullman, ed. D. Reidel Publ. Co., Dordrecht, Holland, 1981, pp. 383-396. B23. Green, J.P. and Weinstein, H. - Recognition, response. Quantum mechanics can account for the affinities of drugs and receptors. The Sciences 1981 (September), 21:27-29. B24. Maayani, S., Hough, L.B., Weinstein, H. and Green, J.P. - Response of the histamine H2-receptor in brain to antidepressant drugs. In: Typical and Atypical Antidepressants, Adv. Biochem. Psychopharmacol. 31 : eds. E. Costa and G. Racagni, (Raven, New York), 1982, pp. 133-147. B25. Weinstein, H., Osman, R., Topiol, S. and Venanzi, C.A. - Molecular determinants for biological mechanisms: Model studies of interactions in carboxypeptidase. In: Quantitative Approaches to Drug Design, J.C. Dearden, ed. Elsevier Science Publ., Amsterdam, Holland, 1983, pp. 81-90. B26. Albuquerque, E.X., Warnick, J.E., Aguayo, L.G., Ickowicz, R.K., Blaustein, M.P., Maayani, S. and Weinstein, H. - Phencyclidine: Differentiation of behaviorally active from inactive analogs based on interactions with channels of electrically excitable membranes and of cholinergic receptors. In:Phencyclidine and Related Arylcyclohexylamines: Present and Future Applications, E.G. Domino and P. Geneste, eds., NPP Books, Ann Arbor, Michigan, 1983, 579-594. B27. Weinstein, H., Liebman, M.N. and Venanzi, C.A. - Theoretical principles of drug action: The use of enzymes to model receptor recognition and activity. In: New Methods in Drug Research. I ., A. Makriyannis, ed., J.R. Prous, S.A., Publ., Barcelona, 1985, pp. 233-246. B28. Weinstein, H., Rabinowitz, J., Liebman, M.N. and Osman, R. - Determinants of molecular reactivity as criteria for predicting toxicity: Problems and approaches. Environmental Health Perspectives, J. McKinney, ed., NIEHS, 1985, 61:147-162. B29. Liebman, M.N. and Weinstein, H. - Heuristic studies of structure-function relationships in enzymes: Carboxypeptidase and thermolysin, In: Structure and Motion: Membranes, Nucleic Acids and Proteins. E. Clementi, G. Corongiu, M.H. Sarma and R.H. Sarma, eds., Adenine Press, N.Y., 1985, pp. 339-359. B30. Osman, R., Weinstein, H., Topiol, S. and Rubenstein, L. - A Molecular theory of recognition and activation at a 5-HT receptor based on a quantum chemical approach to structure activity relationships. Clin. Physiol. Biochem. 1985, 3:80-88. B31. Weinstein, H., Namboodiri, K., Osman, R., Liebman, M.N. and Rabinowitz,J.- Theuse of molecular reactivity criteria to predict toxicity of xenobiotics. In: QSAR in Toxicology and Xenobiochemistry, M. Tichy, ed., Elsevier- Amsterdam, New York, 1985, pp. 451-463. B32. Weinstein, H., Osman, R. and Mazurek, A. P. - Simulations of molecular stereoelectronic mechanisms for the interaction of hallucinogens and indole derivatives at 5-HT receptors. In: Steric Aspects of Biomolecular Interactions, G. Naray - Szabo and S. Kalman , eds., CRC Press, Florida, 1987, pp. 199-210. B33. Weinstein, H. (ed.) - Computational Approaches to Enzyme Structure and Function. Karger, Scientific Publ., Basel, 1986. B34. Weinstein, H. - On the role of computational approaches to enzyme structure and function in the study of molecular processes in biology. Enzyme, 1986 , 36:4-7. B35. Weinstein, H. - Molecular models for muscarinic ligands. Trends in Pharmacol. Sci,. 1986, (July) 7:262-263. B36. Weinstein, H. - Classification based on ligand binding: On the chemical meaning of ligand affinity in studies of drug-receptor interactions. In: Perspectives on Receptor Classification, J. W. Black, P. Gerskowitz and D. Jenkinson, eds., Alan R. Liss Publ., New York, 1987, pp. 41-49. B37. Mercier, G.A., Osman, R. and Weinstein, H. - A molecular theoretical model of recognition and activation at a 5-HT receptor. In: Computer Assisted Modeling of Receptor - Ligand Interactions, R. Rein and A. 8

H. Weinstein, CV Revised - 5/2015 Page 9 of 25 Golombek, eds., Alan R. Liss, Publ., New York, 1989, pp.339-410. B38. Mercier, G.A., Dijkman, J.P., Osman, R. and Weinstein, H. - Effects of macromolecular environments on proton transfer processes: The calculation of polarization. In: Quantum Chemistry: Basic Aspects, Actual Trends, R. Carbo, ed., Elsevier Scientific Publ., Amsterdam, 1989; pp. 577-596. B39. Weinstein, H., Osman, R. and Mercier, G.A.-Recognition and activation of a 5-HT receptor by hallucinogens and indole derivatives. In: NIDA Research Monograph 90, Proc. 50th Ann. Meet. Problems of Drug Dependence, L.S. Harris, ed., 1988, pp.243-255. B40. Weinstein, H. and Osman, R. - Interaction mechanisms at biological targets: Implications for design of serotonin receptor ligands. In: Computer Aided Molecular Design, G.W. Richards, ed., IBC Technical Services, Ltd., London, 1989, pp. 105-118. B41. Weinstein, H., Hori, K., Kushick, J.N., Sussman, F. and Factor, A. - Computer simulation studies of structure-function relations in calcium-binding proteins. In: Proc. 4th Intl. Conf. Supercomputing, L.P. Kartashev and S.I. Kartashev, eds., Intl. Supercomputing Inst., Inc., Florida, 1989, pp. 106-108. B42. Weinstein, H., and Osman, R. - Molecular biophysics of specificity and function in enzymes, receptors and calcium binding proteins. In: Theoretical Biochemistry and Molecular Biophysics: A Comprehensive Survey, D.L. Beveridge and R. Lavery, eds, Adenine Press, NY 1990, pp. 275-289. B43. Weinstein, H. and Osman, R. - Simulations of ligand-receptor interactions as guides for design. In: Frontiers in Drug Research, Alfred Benzon Symposium 28, B. Jensen, F.S. Jorgensen and H. Kofod, eds., Munksgaard, Copenhagen, 1990, pp. 169-182. B44. Weinstein, H., Osman, R., Mercier, G.A.,Mazurek, A.P., Pardo, L., and Rubenstein, L.A. - Theory and computation of molecular mechanisms in biological processes: Radiation-induced damage to DNA and neurotransmitter receptor function; In: Computer Assisted Analysis and Modeling on the IBM 3090, H. U. Brown, ed. MIT Press, Boston, 1990, pp. 629-673. B45. Weinstein, H. - On the chemical basis of specificity and function in biological mechanisms. In: Proc. 6th IFC Symposium, Kyoto, Institute for Fundamental Chemistry, Kyoto, Japan 1991, pp. 169-82 B46. Haaksma, E.E.J., Donne- Op den Kelder, G.M., Timmerman, H. and Weinstein, H. - Theoretical analysis of the activity of dimaprit derivatives on the H2 receptor. In: New Perspectives in Histamine Research, H. Timmerman and H. Van der Goot, eds., Birkhauser Verlag, Basel, 1991, pp.315-324. B47. Osman, R., Miaskiewicz, K. and Weinstein, H. - Structure-function relations in radiation damaged DNA. In: Physical and Chemical Mechanisms in Molecular Radiation Biology , Eds., W.A. Glass and M. N. Varma, Plenum Press, New York 1991, pp.423-451. B48. Weinstein, H. and Mehler, E.L.- Structural specificity in the engineering of biological functions: Insights from the dynamics of calmodulin. In: The Role of Computational Models and Theories in Biotechnology, Ed., J. Bertran, Kluwer, Dordrecht 1992, pp.153-173. B49. Weinstein, H. - Computational simulations of molecular structure, dynamics and signal transduction in biological systems: Mechanistic implications for ecological physical chemistry. In: Ecological Physical Chemistry, Eds., L. Bonati, U. Cosentino, M. Lasagni, D. Pitea and A. Schiraldi. Elsevier, Amsterdam, 1992, pp.1-16. B50. Weinstein, H., Zhang, D. and Ballesteros, J.A- Hallucinogens acting at 5-HT receptors: Towards a mechanistic understanding at atomic resolution. In: Hallucinogens: An Update, Eds., G. Lin and R.A. Glennon, National Inst. on Drug Abuse Research Monograph #146, 1994, pp.241-262. B51. Weinstein, H. and Mehler, E.L.- Ca2+-binding and structural dynamics in the functions of calmodulin. Ann. Rev. Physiol . 1994, 56:213-236. B52. Weinstein, H. and Zhang, D. - Receptor models and ligand-induced responses: New insights for structure- activity relations. “QSAR and Molecular Modeling: Concepts, Computational Tools and Biological Applications” F. Sanz, J. Giraldo and F. Manaut (Eds.) J.R. Prous Science Publ. , Barcelona, 1995 , pp. 497- 507. B53. Ballesteros, J.A. and Weinstein, H.- Integrated methods for the construction of three dimensional models

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H. Weinstein, CV Revised - 5/2015 Page 10 of 25 and computational probing of structure-function relations in G-protein coupled receptors Methods Neurosci. 1995, 25:366-428. B54. Weinstein, H. - E pur si muove: Dynamic modeling of ligand-induced activation in G-protein coupled receptors. Chemical Design & Automation 1995, 10(2):1&39-43. B55. Sassaroli, M. and Weinstein, H. - Book Review: S.H. White, Editor: Membrane Protein Structure: Experimental approaches. The Physiologist, 1996. B56. Pastor, N., Pardo, L. and Weinstein, H. - How the TATA box selects its protein partner. In: Molecular Modeling of Nucleic Acids; ACS Symposium Series No. 682; Eds., N.B. Leontis, and J. SantaLucia, Jr., 1997, pp. 329-345. B57. Scheraga, H. and Weinstein, H. (Guest Editors) – Intl.J. Quantum Chemistry Vol. 75 Number (3),1999: Biophysics Quarterly In Memory of Bernard Pullman, pp. 135-330. B58. Pastor, N., and Weinstein, H. - Protein-DNA interactions in the initiation of transcription: The role of flexibility and dynamics of the TATA recognition sequence and the TATA box binding protein. In: Theoretical Biochemistry- Processes and Properties of Biological Systems; Ed., L. A. Eriksson, Elsevier Science B.V., Amsterdam, 2001, pp. 377-407. B59. Visiers, I., Ballesteros, J.A. and Weinstein, H. – Three-dimensional representations of GPCR structures and mechanisms. In: Methods in Enzymology Vol. 343, 2002, pp. 329-371. B60. Hassan, S.A., Mehler, E.L. and Weinstein H. – Structure calculation of protein segments connecting domains with defined secondary structure: A simulated annealing Monte Carlo combined with biased Scaled Collective Variables technique. In Computational Methods for Macromolecules: Challenges and Applications, Lecture Notes in Computational Science and Engineering (LNCSE), Vol. 24, Ed., T. Schlick and H. H. Gan Springer Verlag, Berlin, 2002, pp.197-231. B61. Filizola, M. Visiers, I., Skrabanek, L., Campagne, F. and Weinstein H. – Functional mechanisms of GPCRs in a structural context. In Strategies in Molecular Neuropharmacology, Eds., A. Schousboe and H. Bräuner-Osborne, Humana Press, 2003, Chapter 13, pp.235-266. B62. Goldberg, N.R., Beuming, T., Weinstein H., and Javitch, J. – A structural context for studying neurotransmitter transporter function In Strategies in Molecular Neuropharmacology, Eds., A. Schousboe and H. Bräuner-Osborne, Humana Press, 2003, Chapter 12, pp.213-234. B63. Weinstein H. – New levels of complexity in the functional roles of modular protein interaction domains: Switches and sockets in the circuit diagrams of cellular Systems Biology. In: Modular Protein Domains, Eds. G. Cesareni, M. Gimona, M. Sudol and M. Yaffe, Wiley-VCH, GmbH, 2004, pp.487-491. B64. Filizola, M., Guo, W., Javitch, J.A. and Weinstein, H. – Oligomerization domains in G-protein coupled receptors: Insights into the structural basis of GPCR association. In The G-protein Coupled Receptor Handbook, Ed. L.A. Devi, Series: Contemporary Clinical Neuroscience, Humana Press, Inc. Totowa, NJ 2005, pp.243-265. B65. Májek P, Elber R, Weinstein H (2008) Pathways of conformational transitions in proteins. In: G.A. Voth, Editor, Coarse-graining of Condensed Phase and Biomolecular Systems, CRC Press/Taylor and Francis Group, Boca Raton (2009). B66. Moreira, I.S., Shi, L., Freyberg, Z., Ericksen, S.S., Weinstein, H., Javitch J.A. (2010) Structural Basis of Dopamine Receptor Activation. In K.A. Neve (ed.), The Dopamine Receptors, 2nd Edition, The Receptors, Humana Press, a part of Springer Science+Business Media, LLC, 2010, pp. 47-73. B67. Weinstein, H., Editor, Comprehensive Biophysics, Volume 9: Simulation and Modeling, Oxford: Academic Press, 2012. 413pp ISBN: 978-0-08-095718-0 http://www.sciencedirect.com/science/referenceworks/9780080957180 B68. Weinstein, H. (2011) Introduction. In: Edward H. Egelman, editor: Comprehensive Biophysics, Vol 9, Simulation and Modeling, Harel Weinstein, Volume Ed. Oxford: Academic Press, (2012), p1. http://www.sciencedirect.com/science/article/pii/B9780123749208009012

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H. Weinstein, CV Revised - 5/2015 Page 11 of 25 B69. Mondal, S., Khelashvili, G., Weinstein, H. (2012) Interactions of the Cell Membrane with Integral Proteins. In: Edward H. Egelman, editor: Comprehensive Biophysics, Vol 9: Simulation & Modeling, Vol.Ed.: Harel Weinstein.Oxford: Academic Press, 2012. pp. 229-242. http://www.sciencedirect.com/science/article/pii/B9780123749208009279

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A. Peer Reviewed Publications A1. Weinstein, H. and Pauncz, R. - Molecular orbital set determined by a localization procedure. Symp. Far. Soc. 1968 , 23-31. A2. Weinstein, H. and Pauncz, R. - Direct optimization approach to molecular electron density calculation, Chem. Phys. Letters, 1972 , 14:161-166. A3. Weinstein, H., Apfelderfer, B.Z. and Berg, R.A. - Quantum mechanical analysis of electronic transitions in some cyanine dye photosensitizers, Photochem. Photobiol. 1973 , 18:175-183. A4. Srebrenik, S. Weinstein, H. and Pauncz, R. - Analytical calculations of atomic and molecular electrostatic potentials from the Poisson equation, Chem. Phys. Letters 1973, 20:419-423. A5. Weinstein, H., Maayani, S., Srebrenik, S., Cohen, S. and Sokolovsky, M. Psychotomimetics as anticholinergic agents II. Quantum Mechanical study of molecular interaction potentials of 1-cyclohexylpiperidine with the cholinergic receptor, Mol. Pharmacol. 1973 , 9:820-834. A6. Maayani, S., Weinstein, H., Cohen, S. and Sokolovsky, M. - Acetylcholine-like molecular arrangement in psychomimetic anticholinergic drugs, Proc. Natl. Acad. Sci., U.S.A. 1973 , 70:3103-3107. A7. Paster, A., Maayani, S., Weinstein, H. and Sokolovsky, M. - Cholinolytic action of phencyclidine derivatives, Eur. J. Pharmacol. 1974 , 25:270-274. A8. Maayani, S., Weinstein, H., Ben-Zvi, N., Cohen, S. and Sokolovsky, M. -Psychomimetics as anticholinergic agents I. 1-cyclohexylpiperidine derivatives: anti-cholinesterase activity and antagonistic activity to acetylcholine, Biochem. Pharm. 1974 , 23:1263-1281. A9. Srebrenik, S., Weinstein, H. and Pauncz, R. - The formulation of molecular forces and their analytic calculations, J. Chem. Phys. 1974 , 61:5050-5053. A10. Weinstein, H. - On the possible use of analytic potentials in Scattered Wave methods, Int. J. Quantum Chem. 1974, S8:123-125. A11. Kistenmacher, T.J., Shigematsu, T. and Weinstein, H. - The effect of substitution on protonation sites: evidence for protonation at N(3) in N(7)-substituted adenine, J. Mol. Struct. 1975 , 25:125-129. A12. Weinstein, H., Politzer, P. and Srebrenik, S. - A misconception concerning the electronic density distribution of an atom, Theor. Chim. Acta. 1975, 38:159-163. A13. Bartlett, R.J. and Weinstein, H. - Theoretical treatment of multiple site reactivity in large molecules, Chem. Phys. Letters 1975, 30:441-445. A14. Srebrenik, S., Pauncz, R. and Weinstein, H. - Some definitions of atomic regions in molecules and solids, Chem. Phys. Letters 1975 , 32:420-425. A15. Politzer, P. and Weinstein, H. - Molecular electrostatic potentials II. Mechanistic aspects of electrophilic interactions of some five-membered heterocycles, Tetrahedron 1975, 31:915-923. A16. Weinstein, H., Maayani, S., Srebrenik, S., Cohen, S. and Sokolovsky, M. - A theoretical and experimental study of the semi-rigid cholinergic agonist-3-acetoxy-quinuclidine, Mol. Pharmacol. 1975, 11:671-689. A17. Weinstein, H. - Some new quantum chemical procedures for the analysis of drug-receptor interactions, Int. J. Quantum Chem. 1975, QBS2:59-69. A18. Weinstein, H., Chou, D., Kang, S., Johnson, C.L. and Green, J.P. - Reactivity characteristics of large molecules and their biological activity: Indolealkylamines on the LSD-serotonin receptor, Int. J. Quantum Chem. 1976, QBS3:135-150. A19. Chang, S.Y., Weinstein, H. and Chou, D. - Perturbation treatment of multiple site reactivity: Molecule- molecule interactions, Chem. Phys. Letters, 1976 ,42:145-150. A20. Weinstein, H., Chou, D., Johnson, C.L. and Green, J.P. - Tautomerism and the receptor action of histamine--a mechanistic model, Mol. Pharmacol. 1976, 12:738-745. A21. Weinstein, H., Srebrenik, S., Maayani, S. and Sokolovsky, M. - A theoretical model study of the comparative effectiveness of atropine and scopolamine action in the central nervous system, J. Theor. Biol. 1977, 64:295-309. 12

H. Weinstein, CV Revised - 5/2015 Page 13 of 25 A22. Osman, R. and Weinstein, H. - Near ab-initio methods for the calculation of large molecules: comparison of pseudopotential and ab-initio results Chem. Phys. Lett 1977 , 49:69-74. A23. Weinstein, H. and Osman, R. - Models for molecular mechanisms in drug- receptor interactions: serotonin and 5-hydroxyindole complexes with imidazolium cation, Int. J. Quantum Chem. 1977, QBS4:253-268. A24. Weinstein, H., Eilers, J.E. and Chang, S.Y. - A modified Hamiltonian method for the study of multiple site reactivity: comparison with perturbation results, Chem. Phys. Letters, 1977, 54:534-539. A25. Green, J.P., Johnson, C.L., Weinstein, H. and Maayani, S. - Antagonism of the histamine-activated adenylate cyclase in brain by D-LSD, Proc. Nat. Acad. Sci. U.S.A., 1977, 74:5697-5701. A26. Chou, D. and Weinstein, H. - Electron charge redistribution following electrophilic attack on heterocycles: nitrogen as a charge transducer, Tetrahedron, 1978, 34:275-286. A27. Edwards, W.D. and Weinstein, H. - On the basis set dependence of reported limitations in predictions from electrostatic potentials, Chem. Phys. Letters 1978, 56:582-584. A28. Weinstein, H., Osman, R., Edwards, W.D. and Green, J.P. - Theoretical models for molecular mechanisms in biological systems: tryptamine congeners on an LSD/serotonin receptor, Int. J. Quantum Chem. 1978, QBS5:449-461. A29. Chang, S.Y. and Weinstein, H. - Perturbation treatment of multiple site reactivity.II: Additivity in trimolecular interactions, Int. J. Quantum Chem. 1978, 14:801-813. A30. Johnson, C.L., Weinstein, H. and Green, J.P. - Studies on histamine H2-receptors coupled to cardiac adenylate cyclase. I. Effects of guanylnucleotides and structural requirements for agonist activity, Biochim. Biophys. Acta. 1979, 587:155-168. A31. Johnson, C.L., Weinstein, H. and Green, J.P. - Studies on histamine H2-receptors coupled to cardiac adenylate cyclase. II. Blockade by H2 and H1 receptor antagonists, Mol. Pharmacol. 1979, 16:417-428. A32. Kang, S., Ernst, L., Weinstein, H. and Osman, R. - 13C NMR chemical shifts and calculated electronic structures of serotonin congeners: relation to biological activity, Mol. Pharmacol. 1979, 16:1031-1039. A33. Politzer, P. and Weinstein, H. - Some relations between electronic distribution and electronegativity, J. Chem. Phys. 1979, 17:4218-4220. A34. Osman, R. and Weinstein, H. - Models for active sites of metalloenzymes: comparison of zinc and beryllium containing complexes. Isr. J. Chem. 1980, 19:149-153. A35. Maayani, S. and Weinstein, H. - "Specific binding" of 3H-phencyclidine: Artifacts of the rapid filtration method, Life Sci. 1980, 26:2011-2022. A36. Osman, R., Topiol, S., Weinstein, H. and Eilers, J.E. - Theoretical studies of molecular complexes: A probe into basis set and correlation effects, Chem. Phys. Lett, 1980, 73:399-403. A37. Osman, R., Topiol, S. and Weinstein, H. - Electron density redistribution in the stabilization of a molecular stacking complex: The nature and correction of basis set superposition errors. J. Comput. Chem. 1981, 2:73-82. A38. Reggio, P.H., Weinstein, H., Osman, R. and Topiol, S. - Molecular determinants for binding of methylenedioxytryptamines at 5-HT/LSD receptors. Int. J. Quantum Chem. 1981, QBS8:373-384. A39. Albuquerque, E.X., Aguayo, L.G., Warnick, J.E., Weinstein, H., Glick, S.D., Maayani, S., Ickowicz, R.K. and Blaustein, M.P. - The behavioral effects of phencyclidine may be due to their blockade of potassium channels. Proc. Natl. Acad. Sci. U.S.A. 1981, 78:7792-7796. A40. Aguayo, L.G., Warnick, J.E., Maayani, S., Glick, S.D., Weinstein, H. and Albuquerque, E.X. - Sites of action of phencyclidine IV. Interaction of phencyclidine and its analogs on ionic channels of the electrically excitable membrane and nicotinic receptor: Implications for behavioral effects. Mol. Pharmacol.1982, 21:637- 647. A41. Venanzi, C.A., Weinstein, H., Corongiu, G. and Clementi, E. - The solvent effect in enzyme-substrate interactions: Models of carboxypeptidase. Int. J. Quantum Chem. 1982, QBS9:355-365. A42. Weinstein, H., Maayani, S. and Pazhenchevsky, B. - Multiple actions of PCP: Discriminant SAR from molecular conformations and assay conditions. Fed. Proc. 1983, 42:2574-2578. A43. D'Amico, G.A., Kline, R.P., Maayani, S., Weinstein, H. and Kupersmith, J. - Effects of phencyclidine on 13

H. Weinstein, CV Revised - 5/2015 Page 14 of 25 cardiac action potential: pH dependence and structure-activity relationships. Eur. J. Pharmacol. 1983, 88:283- 290. A44. Shenker, A., Maayani, S., Weinstein, H. and Green, J.P. - Enhanced serotonin-stimulated adenylate cyclase activity in membranes from adult guinea pig hippocampus. Life Sci. 1983, 32:2335-2342. A45. Mazurek, P.A., Topiol, S., Weinstein, H. and Osman, R. - Theoretical studies on the activation mechanism of the histamine H2-receptor: The guanidine substitution and its role in the partial agonism of N(alpha)- guanylhistamine. Int. J. Quantum Chem. 1983, QBS10:293-300. A46. Weinstein, H., Maayani, S., Pazhenchevsky, B., Venanzi, C. and Osman, R. -Molecular determinants for recognition of phencyclidine derivatives at muscarinic cholinergic receptors. Int. J. Quantum Chem. 1983, QBS10:309-320. A47. Aguayo, L.G., Weinstein, H., Maayani, S., Glick, S.D., Warnick, J.E. and Albuquerque, E.X. - Discriminant effects of behaviorally active and inactive analogs of phencyclidine on membrane electrical excitability. J. Pharmacol. Exp. Ther. 1984, 228:80-87. A48. Ebersole, B.J., Weinstein, H. and Maayani, S. - Differences in 3H-d-lysergic acid diethylamide binding in mouse cortex and hippocampus in vivo and in vitro revealed by radioautography and rapid filtration studies. J. Pharmacol. Exp. Ther. 1984, 228:865-871. A49. Topiol, S., Weinstein, H. and Osman, R. - A theoretical investigation of histamine tautomerism. J. Med. Chem., 1984, 27:1531-1533. A50. Mazurek, A.P., Weinstein, H., Osman, R., Topiol, S. and Ebersole, B.J. -Theoretical and experimental studies of drug-receptor interactions: Determinants for recognition of 5-hydroxytryptamine analogs. Int. J. Quantum Chem. 1984, QBS 11:183-194. A51. Liebman, M.N., Venanzi, C.A. and Weinstein, H. - Structural analysis of carboxypeptidase A and its complexes with inhibitors as a basis for modeling enzyme recognition and specificity. Biopolymers, 1985, 24:1721-1758. A52. Shenker, A., Maayani, S., Weinstein, H. and Green, J.P. - Two 5-HT receptors linked to adenylate cyclase in guinea pig hippocampus are discriminated by 5-carboxamidotryptamine and spiperone. Eur. J. Pharmacol. 1985, 109: 427-429. A53. Topiol, S. Mercier, G., Osman, R. and Weinstein, H., - Computational schemes for modeling proton transfer in biological systems: Calculations on the hydrogen bonded complex [CH3OH.H.NH3]+. J. Comput. Chem., 1985, 6:581-586. A54. Rabinowitz, J.R., Namboodiri, K., and Weinstein, H. - A finite expansion method for the calculation and interpretation of molecular electrostatic potentials. Int. J. Quantum Chem., 1986, 29:1697-1704. A55. Weinstein, H., Mazurek, A.P., Osman, R. and Topiol, S. - Theoretical studies on the activation mechanism of the histamine H2-receptor: The proton transfer between histamine and a receptor model. Mol. Pharmacol., 1986, 29:28-33. A56. Newton, M.V., Hough, L.B. and Weinstein, H. - A metactoid sensitization model for the classification of histamine receptors coupled to 3H-cAMP accumulation in a vesicular preparation of guinea pig cerebral cortex. Ann. N.Y. Acad. Sci., 1987, 494:243-246. A57. Reggio, P,. Topiol, S. and Weinstein, H. -Molecular determinants for the agonist activity of 2- methylhistamine and 4-methylhistamine at H2-receptors. J. Med. Chem, 1986, 29:2412-2415. A58. Mazurek, A.P., Osman, R. and Weinstein, H. - Molecular determinants for recognition of triazole and tetrazole analogs of histamine at H2-receptors. Mol. Pharmacol., 1987,31:345-350. A59. Shenker, A., Maayani, S., Weinstein, H. and Green, J.P. - Pharmacological characteri-zation of two 5- hydroxytryptamine receptors coupled to adenylate cyclase in guinea pig hippocampal membranes. Mol. Pharmacol., 1987, 31:357-367. A60. Namboodiri, K., Osman, R., Weinstein, H. and Rabinowitz, J.R.-Analysis of the molecular electrostatic potential for the prediction of N-oxidation and biological activity of substituted pyridines. Mol. Toxicol., 1987, 1:131-141. 14

H. Weinstein, CV Revised - 5/2015 Page 15 of 25 A61. Osman, R., Namboodiri, K., Weinstein, H. and Rabinowitz, J.R. - Reactivities of acrylic and methacrylic acids in a nucleophilic addition model of their biological activities. J. Amer. Chem. Soc., 1988, 110:1701-1707. 62. Osman, R., Topiol, S., Rubenstein, L. and Weinstein, H. - A molecular model for activation Aof a 5- hydroxytryptamine receptor. Mol. Pharmacol., 1987, 32:699-705. A63. Dijkman, J.P., Osman, R. and Weinstein, H. - Practical considerations in calculations of the proton transfer in a model active site of papain. Int. J. Quant Chem., 1987, QBS 14:211-219. A64. Hori, K., Kushick, J.N., Factor, A. and Weinstein, H. - Parameters and mechanisms of calcium binding to peptides and proteins. Int. J. Quantum Chem., 1987, QBS 14:341-345. A65. Hori, K., Kushick, J.N., and Weinstein, H. - Structural and energetic parameters of Ca2+ binding to peptides and proteins. Biopolymers, 1988, 27:1865-1886. A66. Dijkman, J.P., Osman, R. and Weinstein, H. - A theoretical study of the effect of primary and secondary structure elements on the proton transfer in Papain. Int. J. Quantum Chem., 1988, 35:241-252. A67. Mercier, G.A., Osman, R. and Weinstein, H.- Role of primary and secondary protein structure in neurotransmitter receptor activation mechanisms. Protein Engng., 1988, 2:261-270. A68. Gannon, M.N., Hough, L.B. and Weinstein, H.-A metactoid sensitization model to describe multiple receptors linked to a common response: Application to histamine receptors coupled to 3H-cAMP accumulation in guinea pig cortex. Mol.Pharmacol., 1989, 35:205-213. A69. Carrol M.T., Cheeseman, J.R., Osman, R. and Weinstein, H. - Nucleophilic addition to activated double bonds: Predictions of reactivity from the Laplacian of charge densities. J. Phys. Chem. 1989, 93:5120-5123. A70. Sussman, F. and Weinstein, H. - On the ion selectivity in Ca-binding proteins: The cyclo-(l-Pro-Gly)3 peptide as a model. Proc. Natl. Acad. Sci. USA, 1989, 86:7880-7884. A71. Pardo, L., Mazurek, A.P. Osman, R. and Weinstein, H. - Theoretical studies of the activation mechanism of histamine H2-receptors: Dimaprit and the receptor model. Intl. J. Quantum Chem. 1989, QBS16:281–290 A72. Osman, R., Clark, W.J., Mazurek, A.P., and Weinstein, H. - Theoretical studies of molecular mechanisms of DNA damage induced by hydroxyl radicals. Free Rad. Res. Comms. 1989, 6:131-132. A73. Weinstein, H. and Osman, R.- On the structural and mechanistic basis of function, classification and ligand design for 5-HT receptors., Neuropsychopharmacol.,1990, 3:397-409. A74. Pardo L., Osman, R., Banfelder J., Mazurek, A.P. and Weinstein, H. - Molecular mechanisms of radiation- induced DNA damage: H–abstraction and beta–cleavage. Free. Rad. Res. Comms., 1991, 12-13:461-463. A75. Osman, R., Pardo, L., Banfelder, J., Mazurek, A.P., Shvartzman, L., Strauss, R. and Weinstein, H. – Molecular mechanisms of radiation induced DNA damage: H–addition to bases, direct ionization and double strand break. Free Rad. Res. Comms., 1991, 12–13:465-467. A76. Mehler, E.L., Pascual-Ahuir, J.L. and Weinstein, H. – Structural dynamics of calmodulin and troponin C. Protein Engineering, 1991, 4:625-637. A77. Haaksma, E., Timmerman, H., Weinstein, H. – The effect of a protein environment on the proposed activation mechanism of the histamine H2- receptor. Isr. J Chem. 1991, 31:409-421. A78. Pascual-Ahuir, J.L., Mehler, E.L. and Weinstein, H. - Calmodulin structure and function: Implication of arginine residues in the compaction related to ligand binding. Molec. Engineering, 1991, 1:231-247. A79. Pardo, L., Ballesteros, J.A., Osman, R. and Weinstein, H. - On the use of the transmembrane domain of bacteriorhodopsin as a template for modeling the 3-D structure of G-protein coupled receptors. Proc. Natl. Acad. Sci. USA, 1992, 89:4009-4012. A80. Ballesteros, J.A. and Weinstein, H. - Analysis and refinement of criteria for predicting the structure and relative orientations of transmembranal helical domains. Biophys. J, 1992.62:107-09. A81. Ballesteros, J.A. and Weinstein, H. - The role of Pro/Hyp-kinks in determining the transmembrane helix length and gating mechanism of a [Leu]zervamicin channel. Biophys. J., 1992, 62:110-111. A82. Miaskiewicz, K., Osman, R. and Weinstein, H. - Molecular dynamics simulation of the hydrated d(CGCGAATTCGCG)2 dodecamer. J. Amer. Chem. Soc. 1993, 115:1526-1537. A83. Zhang, D., and Weinstein, H.- Signal transduction by a 5-HT2 receptor: A mechanistic hypothesis from 15

H. Weinstein, CV Revised - 5/2015 Page 16 of 25 molecular dynamics simulations of the 3-D model of the receptor complexed to ligands. J. Med. Chem. 1993, 36:934-938. A84. Mehler, E.L., Kushick, J.N. and Weinstein, H. - Consequences of sequential Ca2+ occupancy for the structure and dynamics of calbindinD9k: Computational simulations and comparison to experimental determinations in solution. Mol. Simulation 1993, 10:309-334. A85. Pardo, L., Osman, R., Weinstein, H. and Rabinowitz, J.R. - Mechanisms of nucleophilic addition to activated double bonds: The 1,2- and 1,4-Michael addition of ammonia. J. Amer. Chem. Soc. 1993, 115: 8263- 8269. A86. Zhang, D. and Weinstein, H. - Ligand selectivity and the molecular properties of the 5–HT2 receptor: Computational simulations reveal a major role for transmem-brane helix 7. Med. Chem Res., 1993, 3:357-369. A87. Zhou, W., Flanagan, C., Ballesteros, J.A., Konvicka, K., Davidson, J.S., Weinstein, H., Millar, R.P., Sealfon, S. - A reciprocal mutation supports helix 2 and helix 7 proximity in the gonadotropin-releasing hormone receptor. Mol. Pharmacol. 1994, 45:165-170. A88. Zhang, D. and Weinstein, H. - Polarity conserved positions in transmembrane domains of G-protein coupled receptors and bacteriorhodopsin. FEBS Letters 1994, 337:207-212. A89. Luo, X., Zhang, D. and Weinstein, H. - Ligand-induced domain motion in the activation mechanism of a G- protein coupled receptor Protein Engng. 1994, 7:1441-1448. A90. Pastor, N., and Weinstein, H. - Electrostatic analysis of DNA binding properties in Lysine-to-Leucine mutants of TATA-box binding proteins. Protein Engng. 1995, 8:543-549. A91. Gulati, J., Akella, A.B, Su, H. Mehler, E.L. and Weinstein, H. - The functional role of Arg–11 in the N- terminal helix of skeletal troponin C: A combined mutagenesis and molecular dynamics investigation. Biochemistry 1995, 34:7378-7355. A92. Sealfon, S.C., Chi, L., Ebersole, B.J., Rodic, V., Zhang, D., Ballesteros, J.A. and Weinstein, H. - Related contributions of specific helix 2 and 7 residues to conformational activation of the serotonin 5-HT2A receptor. J. Biol. Chem. 1995, 270:16683-16688. A93. Zhou, W., Flanagan, C.A., Rodic, V., Chi, L. Weinstein, H., Maayani, S., Millar, R.P., and Sealfon, S.C. - A locus of the gonadotropin releasing hormone receptor which differentiates agonist and antagonist binding sites. J. Biol. Chem. 1995, 270:18853-18857. A94. Guarnieri, F. and Weinstein, H. - Conformational memories and the exploration of biologically relevant peptide conformations: An illustration for the gonadotropin-releasing hormone. J. Amer. Chem. Soc. 1996, 118: 5580-5589. A95. Almaula, N., Ebersole, B.J., Ballesteros, J.A., Weinstein, H. and Sealfon, S.C. - Contribution of a helix 5 locus to selectivity of hallucinogenic and non-hallucinogenic ligands for the human 5-HT2A and 5-HT2C receptors: Direct and indirect effects on ligand affinity mediated by the same locus. Mol. Pharmacol. 1996, 50:34-42. A96. Pardo, L., Battle, M., Dunach, M., and Weinstein, H. - Structure and activity of membrane receptors: Modeling and computational simulation of ligand recognition in a three-dimensional model of the 5-HT1A receptor. J. Biomed. Sci. 1996, 3:98-107. A97. Weinstein, H. and Mehler, E.L. - Structural change mechanisms in regulatory proteins Science, 1996, 271:1792-1793. A98. Almaula, N., Ebersole, B.J., Zhang, D., Weinstein, H. and Sealfon, S.C. - Mapping the binding site pocket of the serotonin 5-HT2A receptor: Ser3.36(159) provides a second interaction site for the protonated amine of serotonin but not of LSD or Bufotenin. J. Biol. Chem. 1996, 271:14672-14675. A99. Fu, D., Ballesteros, J.A., Weinstein, H., Chen, J. and Javitch, J.A. - Residues in the seventh membrane- spanning segment of the dopamine D2 receptor accessible in the binding-site crevice. Biochemistry, 1996, 35:11278-11285. A100. Weng, G., Li, J., Dingus, J., Hildebrandt, J.D., Weinstein, H., and Iyengar, R. - Gß subunit interacts with a peptide encoding region 956-982 of adenylyl cyclase 2 : Crosslinking of the peptide to free Gßg but not the heterotrimer. J. Biol. Chem. 1996, 271:26445-48. 16

H. Weinstein, CV Revised - 5/2015 Page 17 of 25 A101. Pardo, L. and Weinstein, H. - On the Structure and Activity of Membrane Receptors: A Computational Simulation of Ligand-Triggered Activation in a Model 5-HT1A Receptor. Intl. J. Quantum Chem. 1997, 63:767- 780. A102. Gether, U., Ballesteros, J.A., Seifert, R., Sanders-Bush, E., Weinstein, H., and Kobilka, B. Structural instability of a constitutively active G protein coupled receptor: Agonist-independent activation due to conformational flexibility. J. Biol Chem 1997, 272:2587-90 A103. Chen, Y., Weng, G., Li, J., Hary, A., Pieroni, J., Dingus, J., Hildebrandt, J.D., Guarnieri, F., Weinstein, H., and Iyengar, R. - A surface on Gß involved in interactions with adenylyl cyclases. Proc. Natl. Acad. Sci. USA, 1997, 94:2711-2714. A104. Sealfon, C.S., Weinstein, H., and Millar, R.P.-Molecular mechanisms of ligand interaction with the Gonadotropin-releasing hormone receptor. Endocrine Rev. 1997 , 18:180-205. A105. Soirat, A.J.A., Wong, C.F., Osman, R. and Weinstein, H. - Brownian dynamics simulations of the reactions of hydrated electrons with components of DNAs and a DNA double helix. J. Comput. Chem. 1997, 18:888-901. A106. Strahs, D., and Weinstein, H. - Comparative modeling and molecular dynamics studies of the δ, κ, and µ opioid receptors. Protein Engng. 1997, 10:1019-38. (Journal Cover Illustration) A107. Pastor, N., Pardo, L., and Weinstein, H. - Does TATA matter? A structural exploration of the selectivity determinants in its complexes with TBP. Biophys. J.1997, 73:640-52. A108. Gether, U., Lin, S., Ghanouni, P. Ballesteros, J.A., Weinstein, H., and Kobilka, B. - Agonists induce conformational changes in transmembrane domains III and IV of the b2 adrenoreceptor. EMBO J. 1997, 16:6737- 6747. A109. Javitch, J.A., Ballesteros, J.A., Weinstein, H., and Chen, J. - A Cluster of Aromatic Residues in the Sixth Membrane-Spanning Segment of the Dopamine D2 Receptor Is Accessible in the Binding-Site Crevice. Biochemistry, 1998, 37:998-1006. A110. Ballesteros, J.A., Kitanovic, S., Guarnieri, F., Davies, P., Fromme, B.J., Konvicka, K., Chi, L., Millar, R., Davidson, J.S., Weinstein, H., and Sealfon, S. - Functional microdomains in G protein-coupled receptors: The conserved arginine cage motif in the gonadotropin-releasing hormone receptor. J. Biol. Chem., 1998 , 273:10445-10453. A111. Wriggers, W., Mehler, E., Pitici, F., Weinstein, H., and Schulten, K. - Structure and dynamics of calmodulin in solution. Biophys. J. 1998, 74:1622-1639. (Journal Cover Illustration) A112. Pardo, L., Pastor, N., and Weinstein, H. - Progressive DNA bending is made possible by gradual changes in the torsion angle of the glycosyl bond. Biophys J. 1998, 74:2191-98. A113. Carter, J., Gragerov, A., Konvicka, K., Elder, G., Weinstein, H., and Lazzarini, R.A. - Neurofilament assembly: Divergent characteristics of human and rodent NF-L subunits. J. Biol. Chem., 1998, 273:5101-5108. A114. Konvicka, K., Guarnieri, F., Ballesteros, J.A. and Weinstein, H. - A proposed structure for transmembrane segment 7 of G protein-coupled receptors incorporating an Asn-Pro/Asp-Pro motif. Biophys. J. 1998, 75:601- 611. A115. Pardo, L., Pastor, N., and Weinstein, H. - Selective binding of the TATA box-binding protein to the TATA box-containing promoter: Analysis of structural and energetic factors. Biophys. J. 1998, 75:2411-2421. A116. Xu, W., Ozdener, F., Li, J.G., Chen, C., de Riel, J.K., Weinstein, H. and Liu-Chen, L.-Y. - Functional role of the spatial proximity of Asp2.50(114) in TMH2 and Asn7.49(332) in TMH7 of the m opioid receptor. FEBS Letters 1999, 447:318-324. A117. Duong, T-Ha, Mehler, E.L., and Weinstein, H. - Molecular dynamics simulation of membrane bilayers and the stabilization of transmembrane helix-7 of the 5-HT2A receptor. J. Comput. Phys., 1999 , 151:358-387. A118. Pastor, N., MacKerell Jr., A.D. and Weinstein, H. - TIT for TAT: The properties of inosine and adenosine in TATA box DNA, J. Biomol. Struct. Dyn., 1999 , 16:787-810. A119. Hou, W.-S., Bromme, D., Zhao, Y., Mehler, E., Dushey, C., Weinstein, H., Miranda, C.S., Fraga, C., Greig, F., Carey, J., Rimoin, D. L., Desnick, R.J., Gelb, B.D. - Cathepsin K: Characterization of novel mutations in

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H. Weinstein, CV Revised - 5/2015 Page 18 of 25 the pro and mature polypeptide regions causing pychnodysostosis, J. Clin. Inv., 1999 , 103:731-738. A120. Ri, Y., Ballesteros, J.A., Abrams, C.K., Oh, S., Verselis, V.K., Weinstein, H. and Bargiello, T.A. - The role of a conserved proline residue in mediating conformational changes associated with voltage gating of Cx32 gap junctions, Biophys J.,1999, 76:2887-98. A121. Sankararamakrishnan, R., Konvicka, K., Mehler, E.L., and Weinstein, H. - Solvation in simulated annealing and high temperature molecular dynamics of proteins: A restrained water droplet model. Intl. J. Quantum Chem., 2000 , 77:174-186. A122. Flanagan, C.A., Zhou, W., Chi, L., Yuen, T., Rodic, V., Robertson, D., Johnson, M., Holland, P., Millar, R.P., Weinstein, H., Mitchell, R., and Sealfon, S. - The functional microdomain in transmembrane helices 2 and 7 regulates expression, activation and coupling of the GnRH receptor. J. Biol. Chem. 1999, 274:28880-86. A123. Campagne, F. and Weinstein, H. - Schematic representation of residue-based protein context-dependent data: an application to transmembrane proteins. J. Mol. Graphics Model., 1999, 17:207-213. A124. Pardo, L., Campillo, M., Bosch, D., Pastor, N., and Weinstein, H. - Binding mechanisms of TATA Box- binding proteins: DNA kinking is stabilized by specific hydrogen bonds. Biophys J., 2000, 78:1988-1996. A125. Konvicka, K., Campagne, F., and Weinstein, H. – Interactive construction of residue-based diagrams of proteins: The RbDE web service. Protein Engng. 2000, 13:395-396. A126. Flanagan, C.A., Rodic, V., Konvicka, K.,Yuen, T., Chi, L., Rivier, J.E., Millar, R.P., Weinstein, H., and Sealfon, S. - Specific interactions of the Asp2.61(98) side chain of the GnRH receptor contribute differentially to ligand interaction. Biochemistry 2000, 39:8133-8141. A127. Visiers, I., Braunheim, B.B. and Weinstein, H. – Prokink: A protocol for numerical evaluation of helix distortions by proline. Protein Engng. 2000, 13:603-606. A128. Sankararamakrishnan, R., and Weinstein, H. – Molecular Dynamics simulations predict a tilted orientation for the helical region of Dynorphin A(1-17) in dimyristoylphosphatidylcholine bilayers. Biophys. J. 2000, 79:2331- 2344. (Journal Cover Illustration). A129. Javitch, J.A., Shi, L., Simpson, M.M., Chiappa, V., Chen, J., Visiers, I., Weinstein, H. and Ballesteros, J.A. – The fourth transmembrane segment of the dopamine D2 receptor: Accessibility in the binding-site crevice and position in the transmembrane bundle. Biochemistry 2000, 39:12190-12199. A130. Sansom, M.S.P. and Weinstein, H. – Hinges, swivels and switches: The role of prolines in signalling via transmembrane alpha-helices. Trends. Pharmacol Sci. 2000, 21:445-451. (Cover Feature). A131. Pastor, N., Weinstein, H., Jamison, E. And Brenowitz, M. - A detailed interpretation of OH radical footprints in a TBP-DNA complex reveals the role of dynamics in the mechanism of sequence-specific binding. J. Mol. Biol. 2000, 304:55-68. (Journal Cover Illustration) A132. Norregaard, L., Visiers, I., Loland, C., Ballesteros, J., Weinstein, H. and Gether, U. - Structural probing of the dopamine transporter by engineering of artificial Zn2+ binding sites. Biochemistry 2000, 39:15836-15846. A133. Lebrun, A., Lavery, R., and Weinstein, H. - Modeling multi-component protein-DNA complexes: The role of bending and dimerization in the complex of p53 dimers with DNA. Protein Engng. 2001, 14:233-243. A134. Visiers, I., Hassan, S.A. and Weinstein, H. – Differences in conformational properties of the second intracellular loop (IL2) in 5HT2C receptors modified by RNA editing can account for G protein coupling efficiency. Protein Engng. 2001, 14:409-414. A135. Max, M., Shanker, YG, Huang,L, Rong, M, Liu, Z, Campagne, F, Weinstein, H, Damak, S, Margolskee, RF – T1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. Nature Genetics 2001, 28:58-63. A136. Xu, W., Li, J., Chen, C., Huang, P., Weinstein, H., Javitch, J.A., Shi, L., de Rie, J.K.,, and Liu-Chen, L-Y. - Comparison of the amino acid residues in the sixth transmembrane domains accessible in the binding-site crevices of µ, δ and κ opioid receptors. Biochemistry, 2001, 40:8018-8029. A137. Li, J., Huang, P., Chen, C., de Riel, J.K.,, Weinstein, H. and Liu-Chen, L-Y. – Constitutive activation of the µ opioid receptor by mutation of D3.49(164), but not D3.32(147): D3.49(164) is critical for stabilization of the inactive form of the receptor and for its expression. Biochemistry, 2001, 40:12039-12050.

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H. Weinstein, CV Revised - 5/2015 Page 19 of 25 A138. Huang, P., Li, J., Visiers, I., Weinstein, H. and Liu-Chen, L-Y. – Functional role of a conserved motif in TM6 of the rat µ opioid receptor: Constitutively active and inactive receptors result from substitutions of Thr6.34(279) with Lys and Asp. Biochemistry, 2001, 40:13501-09. A139. Sankararamakrishnan, R. and Weinstein, H. – Positioning and stabilization of Dynorphin peptides in membrane bilayers: The mechanistic role of aromatic and basic residues revealed from comparative MD simulations. J. Phys. Chem. B 2002, 106:209-218. A140. Visiers, I., Ebersole, B.J., Dracheva, S., Ballesteros, J.A., Sealfon, S.C. and Weinstein, H. - Structural Motifs as Functional Microdomains in G-protein-coupled receptors: Energetic considerations in the mechanism of activation of the Serotonin 5-HT2A receptor by disruption of the ionic lock of the arginine cage. Intl. J. Quantum Chem., 2002,88:65-75. A141. Ceruso, M. and Weinstein, H. – Structural mimicry of proline kinks: Tertiary packing interactions support local structural distortions. J. Mol. Biol., 2002, 318:1237-1249. A142. Prioleau, C.,Visiers, I., Ebersole, B.J., Weinstein, H. and Sealfon, S.C.– Conserved helix7 Tyrosine acts as a multistate conformational switch in the 5-HT2C receptor: Identification of a novel “locked-on” phenotype and double revertant mutations. J. Biol. Chem., 2002, 277:36577-36584. A143. Filizola, M., Olmea, O. and Weinstein, H. – Prediction of heterodimerization interfaces of G-protein coupled receptors with a new subtractive correlated mutation method. Protein Engng., 2002, 15:881-885. A144. Huang, P., Visiers, I., Weinstein, H. and Liu-Chen, L-Y. – The local environment at the cytoplasmic end of TM6 of the µ opioid receptor differs from those of rhodopsin and monoamine receptors: Introduction of an ionic lock between the cytoplasmic ends of helices 3 and 6 by a L6.30(275)E mutation inactivates the µ opioid receptor and reduces the constitutive activity of its Thr6.34(279)K mutant. Biochemistry, 2002, 41:11972-11980. A145. Filizola, M. and Weinstein, H. – Structural models for dimerization of G-protein coupled receptors: The opioid receptor homodimers. Biopolymers: (Peptide Science) 2002, 66:317-325 (Journal Cover Illustration). A146. Mehler, E.L., Periole, X., Hassan, S.A., and Weinstein, H. – Key issues in the computational simulation of GPCR function: representation of loop domains. J Comp Assist Molec Design, 2002, 16:841-853. A147. Hassan, S.A., Mehler, E.L., Zhang, D. and Weinstein, H. - Molecular Dynamics simulations of peptides and proteins with an Implicit Solvent Model Based on Screened Coulomb Potentials. PROTEINS: Struct, Funct Genetics, 2003, 51:109-125 (Journal Cover Illustration). A148. Ebersole, B.J., Visiers, I., Weinstein, H. and Sealfon, S.C. – Molecular basis of partial agonism: Orientation of indoleamine ligands in the binding pocket of the human 5-HT2A serotonin receptor determines relative efficacy. Mol. Pharm., 2003, 63:36-43. A149 Sun, J., Viadiu, H., Aggarwal, A.K. and Weinstein, H. - Energetic and structural considerations for the mechanism of protein sliding along DNA in the nonspecific BamHI-DNA complex. Biophys. J. 2003, 84:3317- 3325. A150 Visiers, I., Weinstein, H., Rudnick, G. and Stephan, M.M. – A second site rescue mutation partially restores functional expression to the serotonin transporter mutant V382P. Biochemistry, 2003,42:6784-93. A151 Skrabanek, L., Campagne, F. and Weinstein, H. – Building protein diagrams on the web with the residue- based diagram editor RbDe, Nucl. Acid Res. 2003, 31:3856-58. A152 Goldberg, N.R, Beuming, T., Soyer, O.S., Goldstein, R.A., Weinstein, H., and Javitch, J.A. – Probing conformational changes in neurotransmitter transporters: a structural context. Eur J. Pharmacol, 2003, 479:3-12. A153 Campagne, F. Bettler, E., Vreind, G. and Weinstein, H. – Batch mode generation of residue-based diagrams of proteins, Bioinformatics, 2003, 19:1854-55. A154 Ceruso, M, Periole, X.. and Weinstein, H. – Molecular Dynamics simulations of transducin: Interdomain and front to back communication in activation and nucleotide exchange. J. Mol. Biol., 2004, 338:469-481. A155 Beuming, T., and Weinstein, H.- A knowledge-based scale for the analysis and prediction buried and exposed faces of transmembrane proteins, Bioinformatics, 2004, 20:1822-35. A156 Filizola, M., Hassan, S.A., Artoni, A., Coller, B.S., and Weinstein, H. – Mechanistic insights from a refined three-dimensional model of integrin aIIbb3, J. Biol. Chem. 2004 279: 24624-24630. 19

H. Weinstein, CV Revised - 5/2015 Page 20 of 25 A157 Campagne, F., Neves, S., Chang, CW, Skrabanek, L., Ram, PT., Iyengar, R. and Weinstein, H. – Quantitative information management for the biochemical computation of cellular networks, Science STKE. 2004, 248:PL11 (1-12). A158 Sankararamakrishnan, R. and Weinstein, H.- Surface tension parametrization in MD simulations of a phospholipid bilayer membrane: Calibration and effects. J. Phys. Chem. B, 2004, 108:11802-11811. A159 Kortagere, S., Gmeiner, P., Weinstein, H. and Schetz, J.A. – Certain 1,4-disubstituted aromatic piperazines with extreme selectivity for the dopamine D4 receptor interact with a common receptor microdomain. Mol. Pharmacol, 2004, 66:1491-99. A160 Beuming, T., Skrabanek, L., Niv, M.Y., Mukherjee, P. & Weinstein, H. – PDZbase:A protein-protein interaction database for PDZ domains. Bioinformatics, 2005, 21(6):827-828. A161 Beuming, T. and Weinstein, H. – Modeling membrane proteins based on low-resolution electron microscopy maps: A template for the TM domains of the oxalate transporter OxlT. Protein Engng. Des. Select., 2005, 18:119-125. A162 Madsen, K.L., Beuming, T., Niv, M., Chang, V., Dev, K.K., Weinstein, H. and Gether U. – Molecular determinants for the complex binding specificity of the PDZ domain in PICK1. J Biol Chem, 2005, 280:20539- 20548. A163 Filizola, M. and Weinstein, H. – The study of G-Protein Coupled Receptor oligomerization with computational modeling and bioinformatics. FEBS J., 2005, 272:2926-2938. A164 Carter M. , Chen X., Slowinska B., Minnerath S., Glickstein S, Shi L., Campagne F., Weinstein H. Ross M.E. - Crooked tail (Cd) Model of Human Folate Responsive NTD is Mutated in Wnt Co-receptor LRP6. Proc Natl Acad Sci USA, 2005, 102:12843-12848. A165 Niv, M.Y. and Weinstein, H. – A flexible docking procedure for the exploration of peptide binding selectivity to known structures and homology models of PDZ domains. J Amer Chem Soc, 2005, 127:14072- 14079. A166 Filizola, M. and Weinstein, H. – The structure and dynamics of GPCR oligomers: A new focus in models of cell-signaling mechanisms and drug design. Curr. Opin. Drug Disc. Devel., 2005, 8:577-584. A167 Sen, N., Shi, L., Beuming, T., Weinstein, H. and Javitch, J.A. - A pincer-like configuration of TM2 in the human dopamine transporter is responsible for indirect effects on cocaine binding. Neuropharmacol., 2005, 49:780-790. A168 Guo, W., L. Shi, M. Filizola, H. Weinstein, and J.A. Javitch, Crosstalk in G protein-coupled receptors: Changes at the transmembrane homodimer interface determine activation. Proc Natl Acad Sci, USA 2005, 102:17495-17500. Faculty of 1000 Biology: http://www.f1000biology.com/article/id/1059750/evaluation A169 Weinstein, H. – Hallucinogen actions on 5-HT receptors reveal distinct mechanisms of activation and signaling by G protein-coupled receptors. AAPS Journal, 2006, 7(4):E871-E884. A170 Yio, X., Diamond, M., Zhang, J-Y, Weinstein, H., Wang, L-H, Werther, L. and Itzkowitz, S. – Trefoil factor family-1 mutations enhance gastric cancer cell invasion through distinct signaling pathways. Gastro-enterology, 2006, 130:1696-1706. A171 Mehler, E.L., Hassan, S.A., Kortagere, S., and Weinstein, H. – Ab initio computational modeling of loops in GPCRs. PROTEINS: Struct, Funct Genetics, 2006, 64(3):673-90. A172 Quick, M., Yano, H., Goldberg, N.R., Duan, L., Beuming, T., Shi L., Weinstein, H. and Javitch, J.A. - State-dependent conformations of the translocation pathway in the tyrosine transporter Tyt1, a novel neurotransmitter:sodium symporter from Fusobacterium nucleatum. J. Biol. Chem. 2006, 281:26444-54. PMID: 16798738 A173 Basdevant, N., Weinstein, H. and Ceruso, M. - Thermodynamic basis for promiscuity and selectivity in protein-protein interactions: PDZ domains, a case study. J. Amer. Chem. Soc., 2006, 128(39):12766-77. A174 Niv, MY, Skrabanek, L, Filizola, M and Weinstein, H – Modeling activated states of GPCRs: The rhodopsin template. J Comput Assist Mol Design, 2006, 20:437-448.

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H. Weinstein, CV Revised - 5/2015 Page 21 of 25 A175 Beuming, T., Shi, L., Javitch, J.A. and Weinstein, H. - A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function. Mol. Pharmacol., 2006, 70:1630-42. PMID: 16880288 A176 Filizola, M, Wang, SX and Weinstein, H – First nanosecond time-scale molecular dynamics simulations of a rhodopsin dimer. J Comput Assist Mol Design, 2006, 20:405-416. A177 Gümüs, ZH, Du, B, Mukherjee, P, Subbaramaiah, K, Dannenberg, AJ and Weinstein, H. –Systematic analysis of tobacco smoke induced changes in oral epithelial cell transcriptome. AACR Meeting 2006:B103. A178 Urban, J.D., Clarke, W.P., von Zastrow, M., Nichols, D.E., Kobilka, B., Weinstein, H., Javitch, J.A., Roth, B.L., Christopoulos, A., Sexton, P.M., Miller, K.J., Spedding, M., Mailman, R.B. - Functional selectivity and classical concepts of quantitative pharmacology: JPET Perspective in Pharmacology, J. Pharmacol. Exptl. Therap., 2007, 320:1-13. A179 Niv, M, Ripoll, D, Vila, J, Liwo, A, Vanamee, E, Aggarwal, A, Weinstein, H and Scheraga, H. – Topology of Type II REases revisited: structural classes and the common conserved core. Nucleic Acid Research, 2007, 35:2227-2237. A180 Sun, J and Weinstein, H. - Towards realistic modeling of dynamic processes in cell signaling: Quantification of macromolecular crowding effects. J Chem Physics, 2007, 127(15):155105-16. A181 Niv, MY, Skrabanek, L, Roberts, RJ, Scheraga, H, and Weinstein H – Identification of GATC- and CCGG-recognizing TypeII REases and their putative specificity-determining positions using Scan2S – A novel motif scan algorithm with optional secondary structure constraints. Proteins, 2008 May 1;71(2):631- 40. PMID: 17972284 A182 Taylor, MS, Fung, HK, Rajgaria, R, Filizola, M, Weinstein, H and Floudas, C - Mutations affecting the oligomerization interface of G-Protein Coupled Receptors revealed by a novel de-novo protein design framework. Biophys J. 2008 Apr 1;94(7):2470-81. PMID: 18178645 A183 Khelashvili, G, Weinstein, H and Harries, D - Protein diffusion on charged membranes: A dynamic mean-field model describes time evolution and lipid reorganization. Biophys J. 2008 Apr 1;94(7):2580-97. PMID: 18065451 Faculty of 1000 Biology http://www.f1000biology.com/article/id/1105211/evaluation A184 Madsen, KL, Eriksen, J, Milan-Lobo, L, Han D, Niv MY, Ammendrup-Johnsen, I, Henriksen, U, Bhatia, V, Stamou, D, Sitte, HH, McMahon, HT, Weinstein, H and Gether U - Membrane localization is necessary and sufficient for activation of the PICK1 BAR (Bin/amphiphysin/Rvs) domain. Traffic, 2008 9(8):1327-43. PMID: 18466293 A185 Gümüs, ZH, Du, B, Mukherjee, P, Subbaramaiah, K, Dannenberg, AJ and Weinstein, H. - Effects of tobacco smoke on gene expression and cellular pathways in a cellular model of oral leukoplakia. Cancer Prevention Res., 2008 2:100-111. A186 Kniazeff J, Shi L, Loland CJ, Javitch JA, Weinstein H, Gether U. - An intracellular interaction network regulates conformational transitions in the dopamine transporter. J Biol Chem, 2008 283 (25):17691-701 PMID: 18426798 A187 Han, DS, Wang, SX and Weinstein, H. - Active state-like conformational elements in the beta2-AR and a photo-activated intermediate of rhodopsin identified from dynamic properties of GPCRs. Biochemistry (Rapid Report), 2008 Jul 15;47(28):7317-21. PMID: 18558776 A188 Shi, L, Quick, M, Zhao, Y, Weinstein, H and Javitch, JA - The mechanism of sodium-coupled symport by a homolog of neurotransmitter transporters: Two substrates are required” Molecular CELL, 2008 30:667–677. PMID: 18570870 A189 Beuming, T, Bergmann, ML, Shi, L, Gracia, L, Raniszewska K, Newman, AH, Javitch, JA, Weinstein, H, Gether U and Loland, CJ - The binding sites for cocaine and dopamine in the dopamine transporter are overlapping. Nature Neurosci, 2008 11(7):780-9. Epub 2008 Jun 22. PMID: 18568020. A190 Ericksen SS, Cummings DF, Weinstein H, Schetz JA. - Ligand selectivity of D2 dopamine receptors is modulated by changes in local dynamics produced by sodium binding. J Pharmacol Exp Ther. 2009 Jan;328(1):40-54. Epub 2008 Oct 10. PMID: 18849360 . 21

H. Weinstein, CV Revised - 5/2015 Page 22 of 25 A191 Chang CW, Poteet E, Schetz JA, Gümüş ZH, Weinstein H. - Towards a quantitative representation of the cell signaling mechanisms of hallucinogens: Measurement and mathematical modeling of 5-HT1A and 5-HT2A receptor-mediated ERK1/2 activation. Neuropharmacology 2009 56:213–225. PMID: 18762202 A192 Khelashvili G, Grossfield A, Feller SE, Pitman MC, Weinstein H. - Structural and dynamic effects of cholesterol at preferred sites of interaction with rhodopsin identified from microsecond length molecular dynamics simulations. Proteins 2009 76(2):403-17 PMID: 19173312 A193 Guptaroy B, Zhang M, Bowton E, Binda F, Shi L, Weinstein H, Galli A, Javitch JA, Neubig RR, Gnegy ME. – A juxtamembrane mutation in the n-terminus of the dopamine transporter induces preference for an inward- facing conformation. Mol Pharmacol. 2009 75(3):514-24. PMID: 19098122 A194 Quick M, Lund Winther A-M, Shi L, Nissen P, Weinstein H, Javitch JA - Binding of an octylgluco-side detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation. Proc Natl Acad Sci U S A. 2009 106:5563–5568. PMID: 19307590 A195 Han Y, Moreira IS, Urizar E, Weinstein H, Javitch JA. - Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation. Nature Chem Biol. 2009 Sep;5(9):688-95. PMID: 19648932 A196 Khelashvili G, Harries D, Weinstein H. - Modeling membrane deformations and lipid demixing upon protein-membrane interaction: the BAR dimer adsorption. Biophys J. 2009 Sep 16;97(6):1626-35.PMID: 19751667 A197 Thorsen TS, Madsen KL, Rebola N, Rathje M, Anggono V, Bach A, Moreira IS, Stuhr-Hansen N, Dyhring T, Peters D, Beuming T, Huganir R, Weinstein H, Mulle C, Strømgaard K, Rønn LC, Gether U. - Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD. Proc Natl Acad Sci U S A. 2010 107:413-418. PMID: 20018661 A198 Zhao Y, Quick M, Shi L, Mehler EL, Weinstein H, Javitch JA - Substrate-dependent proton antiport in neurotransmitter:sodium symporters. Nature Chem Bio 2010 6:109-116. PMID: 20081826 A199 Zhao Y, Terry D, Shi L, Weinstein H, Blanchard, SC, Javitch JA – Single molecule studies of the allosteric modulation of intracellular gating in a neurotransmitter transporter homolog. Nature 2010, May 13;465(7295):188- 93. PMID: 20463731. A200 Claxton, DP, Matthias Quick M, Shi L, Delmondes de Carvalho F, Weinstein H, Javitch JA, Mchaourab HS - Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters. Nature Struct Mol Bio 2010 Jul;17(7):822-9. PMID: 20562855 A201 Bach A, Stuhr-Hansen N, Thorsen TS, Bork N, Moreira IS, Frydenvang K, Padrah S, Christensen SB, Madsen KL, Weinstein H, Gether U, Strømgaard K. - Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1. Org Biomol Chem. 2010 Oct 7;8(19):4281-8. PMID: 20668766 A202 Khelashvili G, Mondal S, Andersen OS, Weinstein H. - Cholesterol modulates the membrane effects and spatial organization of membrane-penetrating ligands for G-protein coupled receptors. J Phys Chem B. 2010 Sep 23;114(37):12046-57. PMID: 20804205 A203 Shan J, Weinstein H, Mehler EL. - Probing the Structural Determinants for the Function of Intracellular Loop 2 in Structurally Cognate G-Protein-Coupled Receptors. Biochemistry. 2010 Dec 21; 49(50):10691-701. PMID: 21062002 A204 Shi, L, and Weinstein, H – Conformational rearrangements to the intracellular open states of the LeuT and ApcT transporters are modulated by common mechanisms. Biophys J. 2010 Dec 15; 99(12):L103-5. PMID: 21156121. A205 Bisgaard H, Larsen MA, Mazier S, Beuming T, Newman AH, Weinstein H, Shi L, Loland CJ, Gether U. - The binding sites for benztropines and dopamine in the dopamine transporter overlap. Neuropharmacology. 2011 Jan; 60(1):182-90. Epub 2010 Sep 6. PMID: 20816875 A206 Gümüs, ZH, Siso-Nadal F, Gjyrezi A, McDonagh P, Giannakakou P and Weinstein, H. – Quantifica-tion and analysis of combination drug synergy in high-throughput transcriptome studies. 2010 IEEE Intl. Conf. Bioinformatics Bioengineering, IEEE Computer Soc., 2010 238-243. DOI 10.1109/BIBE.2010.46

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H. Weinstein, CV Revised - 5/2015 Page 23 of 25 A207 Shi L, Srdanovic M, Beuming T, Skrabanek L, Javitch JA and Weinstein, H. – TRAC- a platform for structure-function studies of NSS proteins integrates information from bioinformatics and biomedical literature. 2010 IEEE Intl. Conf. Bioinformatics Bioengineering, IEEE Computer Soc., 2010 267-272. DOI 10.1109/BIBE.2010.51 A208 He Y, Liwo A, Weinstein H, Scheraga HA. - PDZ Binding to the BAR Domain of PICK1 is Elucidated by Coarse-grained Molecular Dynamics. J Mol Biol. 2011 Jan 7;405(1):298-314. Epub 2010 Nov 2. PMID: 21050858 A209 Zhao Y, Terry D, Shi L, Weinstein H, Blanchard, SC, Javitch JA – Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homolog Nature 2011 June 2; 474(7349):109-13. PMID: 21516104 A210 Shan J, Javitch JA, Shi L, Weinstein H. -The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter. PLoS One 2011 Jan 27 ;6(1): e16350. PMID: 21298009 A211 Han DS, Golebiewska U, Stolzenberg S, Scarlata S, Weinstein H. - A dynamic model of membrane- bound Phospholipase Cβ2 activation by Gβγ subunits. Mol Pharmacol. 2011 Jun 21. 80:434-445 PMID: 21693623 A212 Weinstein H., Scarlata S, - The correlation between multidomain enzymes and mutiple activation mechanisms – The case of phospholipase Cbeta and its membrane interactions. Biochim Biophys Acta 2011 Dec; 1808(12):2940-7. PMID: 21906583 A213 Mondal S, Khelashvili G, Shan J, Andersen OS, Weinstein H. - Quantitative Modeling of Membrane Deformations by Multihelical Membrane Proteins: Application to GPCRs. Biophys J. 2011 101(9) 2092–2101. PMID: 22067146; PMC 3207176 A214 Quick M, Shi L, Zehnpfennig B, Weinstein H, Javitch JA - Experimental conditions can obscure the second high-affinity site in LeuT. Nature Struct Mol Biol – 2012 Jan 15;19(2):207-11. PMID: 22245968 A215 Stolzenberg S, Khelashvili G, Weinstein H - Structural Intermediates in a Model of the Substrate Translocation Path of the Bacterial Glutamate Transporter Homologue GltPh. J Phys Chem B - 2012 May 10; 116(18):5372-83. PMID: 22494242 A216 Shan J, Khelashvili G, Mondal S, Mehler EL, Weinstein H. - Ligand-dependent conformations and dynamics of the serotonin 5-HT2A receptor determine its activation and membrane-driven oligomerization properties PLoS Comput Biol 2012 8(4):e1002473. PMID: 22532793 A217 Khelashvili G, Albornoz PB, Johner N, Mondal S, Caffrey M, Weinstein H. - Why GPCRs behave differently in cubic and lamellar lipidic mesophases. J Am Chem Soc. 2012 Sep 26;134(38):15858-68. Epub 2012 Sep 12. PMID: 22931253 A218 Khelashvili G, Galli A, Weinstein H. - PIP2 lipids regulate the phosphorylation of Syntaxin N-terminus by modulating both its position and local structure. Biochemistry 2012 Oct 2;51(39):7685-98. PMID: 22950482 A219 Zhao C, Stolzenberg S, Gracia, L, Weinstein, H, Noskov S, Shi L. – Ion-controlled conformational dynamics in the outward-open transition from an occluded state of LeuT. Biophys J. 2012 103:878-888. PMID: 23009837 A220 Plenge P, Shi L, Beuming, T, Te J, Newman AH, Weinstein, H, Gether U and Loland, CJ - Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter. J Biol Chem. 2012 Sep 24. 287:39316-39326. PMID: 23007398 A221 *Mondal S, Khelashvili G, Shi L, and Weinstein H - The cost of living in the membrane: A case study of hydrophobic mismatch for the multi-segment protein LeuT. Chem Phys Lipids 2013 169 : 27– 38. PMID: 23376428 PMCID: PMC3631462 NIHMSID: NIHMS440893 A222 Kantcheva AK, Quick M, Shi L, Lund Winther AM, *Stolzenberg S, Weinstein H, Javitch JA, and Nissen P - Chloride binding of neurotransmitter sodium symporters. Proc Natl Acad Sci USA 2013 110(21):8489-94. PMID:23641004 A223 Khelashvili G, *Levine MV, Shi L, Quick M, Javitch JA, Weinstein H. - The membrane protein LeuT in micellar systems: Aggregation dynamics and detergent binding to the S2 site. J Am Chem Soc. 2013 Sep 25;135(38):14266-75. PMID:23980525 A224 *Mondal S, Johnston JM, Wang H, Khelashvili G, Filizola M, Weinstein H. - Membrane Driven Spatial Organization of GPCRs. Nature publ Sci Rep. 2013 Oct 9;3:2909. doi: 10.1038/srep02909. PMID: 24105260 23

H. Weinstein, CV Revised - 5/2015 Page 24 of 25 A225 *Mondal S, Khelashvili G, Johner N, Weinstein H. – How the dynamic properties and functional mechanisms of GPCRs are modulated by their coupling to the membrane environment. Adv Exp Med Biol. 2013 796:55-74. PMID: 24158801 A226 *LeVine, MV, Weinstein, H - NbIT - a new information theory-based analysis of allosteric mechanisms reveals residues that underlie function in the leucine transporter LeuT. – PLoS Comput Biol 2014 May 1; 10(5): e1003603. PMID: 24785005 PMCID: PMC4006702. A227 Johner N, *Mondal S, Morra G, Caffrey M, Weinstein H, Khelashvili G. - Protein and Lipid Interactions Driving Molecular Mechanisms of in meso Crystallization. J Am Chem Soc. 2014 Feb 26; 136(8):3271-84 PMID: 24494670 PMCID: PMC3985912. A228 Dehnes Y, Shan J, Beuming, T, Shi L, Weinstein H, Javitch JA – Conformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocation. Neurochem Intl. 2014 Jul; 73:4-15. PMID: 24576496 PMCID: PMC4058377. A229 *LeVine MV, Perez-Aguilar JM, Weinstein, H - N-body Information Theory (NbIT) analysis of rigid-body dynamics in intracellular Loop 2 of the 5-HT2A receptor – Proceedings International Work-Conference on Bioinformatics and Biomedical Engineering (IWBBIO- 2014) – Eds.: Francisco Ortuño and Ignacio Rojas Deposito Legal: 978- 84-15814-84-9, I.S.B.N: GR 738/2014, Vol 2, pp-1190-1200. A230 Kazmier K, Sharma S, Quick M, Islam SM, Roux B, Weinstein H, Javitch JA, Mchaourab HS - Conformational dynamics of ligand-dependent alternating access in LeuT – Nature Struct Mol Biol. 2014 - 21(5):472-9. PMID: 24747939 PMCID: PMC4050370. A231 Hamilton PJ, Belovich AN, Khelashvili G, Saunders C, Kevin Erreger K, Javitch JA, Sitte HH, Weinstein H, Matthies HJG, and Aurelio Galli A. - Phosphatidylinositol (4,5)-bisphosphate (PIP2) regulates psychostimulant behaviors through its interaction with a membrane protein - Nature Chem Biol. 2014 – 10(7):582-9. PMID:24880859 PMCID:PMC4062427. A232 Hansen FH, Skjørringe T, Yasmeen S, Arends NV, Sahai MA, Erreger K, Andreassen TF, Holy M, Hamilton PJ, Neergheen V, Karlsborg M, Newman AH, Pope S, Heales SJR, Friberg L, Law I, Pinborg LH, Sitte HH, Loland C, Shi L, Weinstein H, Galli A, Hjermind LE, Møller LB, Gether U. – Missense mutations in the dopamine transporter gene associate with adult parkinsonism and ADHD – J. Clin. Inv. 2014 124(7):3107-20 PMID:24911152 PMCID: PMC4071392. A233 *Mondal S, Khelashvili G, Weinstein H. – Not Just an Oil Slick: How the Energetics of Protein-Membrane Interactions Impacts the Function and Organization of Transmembrane Proteins. Biophys J 2014 106:2305- 2316. PMID: 24896109. PMCID: PMC4052241. A234 Handschuh K, Feenstra J, Koss M, Ferretti E, Risolino M, Zewdu R, Sahai MA, Be´nazet J-D, Peng XP, Depew MJ, Quintana L, Sharpe J, Wang B, Alcorn H, Rivi R, Butcher S, Manak JR, Vaccari T, Weinstein H, Anderson KV, Lacy E and Selleri L - ESCRT-II/Vps25 Constrains Digit Number by Endosome-Mediated Selective Modulation of FGF-SHH Signaling. CELL Reports 2014 Oct 23; 9(2):674-87 PMID: 25373905 PMCID: PMC4223648. A235 Borre L, Andreassen TF, Shi L, Weinstein H, Gether U - The second sodium site in the dopamine transporter controls cation permeation and is regulated by chloride. J Biol Chem. 2014 Sep 12; 289(37):25764- 73. PMID: 25063810 PMCID: PMC4162178. A236 Perez-Aguilar JM, Shan J, LeVine MV, Khelashvili G, Weinstein H. - A functional selectivity mechanism at the serotonin-2A GPCR involves ligand-dependent conformations of intracellular loop 2. J Am Chem Soc. 2014 Nov 12;136(45):16044-54. PMID: 25314362 PMCID: PMC4235374. A237 Sensoy O, Weinstein H - A mechanistic role of Helix 8 in GPCRs: Computational modeling of the dopamine D2 receptor interaction with the GIPC1-PDZ-domain. Biochim Biophys Acta. 2015 Jan 12. 1848: 976–983. PMID: 25592838. A238 Akyuz N, et al. - Transport domain unlocking sets the uptake rate of an aspartate transporter. Nature. 2015 518(7537):68-73.

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H. Weinstein, CV Revised - 5/2015 Page 25 of 25 A239 Khelashvili G, *Doktorova M, Sahai MA, Johner N, Shi L, Weinstein H. - Computational modeling of the N- terminus of the human dopamine transporter and its interaction with PIP2 -containing membranes. Proteins 2015 May; 83(5):952-69. PMID: 25739722. PMCID: PMC4400265 A240 Khelashvili G and Weinstein H - Functional mechanisms of neurotransmitter transporters regulated by lipid-protein interactions of their terminal loops. Biochim Biophys Acta. 2015 Apr 4. pii: S0005-2736(15)00104-2. doi: 10.1016/j.bbamem.2015.03.0 PMID:25847498 A241 Stolzenberg S, Quick M, Zhao C, Gotfryd K, Khelashvili G, Gether U, Loland CJ, Javitch JA, Noskov S, Weinstein H, Shi L - Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters. J Biol Chem. 2015 290(22):13992-4003. PMID: 25869126 A242 *LeVine MV and Weinstein H – AIM for Allostery: Using the Ising Model to Understand Information Processing and Transmission in Allosteric Biomolecular Systems. Entropy 2015 17:2895-2918.

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