product data sheet

Anti-GFRα-3 Antibody

ORDERING INFORMATION SPECIFICATION SUMMARY Catalog No.: 1137 Antigen: Peptide corresponding to aa 347- Size: 100 ug IgG in PBS, pH 7.4, purified 360 of mouse GFRα-3. by immunoaffinity chroma-tography. Host Species: Rabbit Stabilizers: None BACKGROUND Preservatives: 0.02% sodium azide. Members of the glial cell line-derived neurotrophic factor (GDNF) family, including SPECIFICITY GDNF and (NTN), play key roles This antibody recognizes human, mouse, in the control of vertebrate neuronal α survivial and differentiation. A new member and rat GFR -3 (approx. 43 kD). of the GDNF family was recently identified and designated persephin. Physiological APPLICATIONS responses to these Immunoblotting: use at 1:500-1:1,000 requrie two receptor subunits, the novel dilution. glycosylphosphatidylinositol linked protein Positive control: Tissue lysates of mouse GFRα and Ret receptor kidney, liver, or heart. GFRβ. Following the identification of GFRα-1 and –2, another receptor in the DILUTION INSTRUCTIONS GFR family was identified in human and Dilute in PBS or medium which is identical mouse and designated GFRα-3. GFRα-3 to that used in the assay system. binds persephin. Thus, persephin, GFRα-3, and Ret PTK form a complex to transmit the STORAGE AND STABILITY persephin signal and to mediate persephin This antibody is stable for at least one (1) o function. year at -20 C. Avoid multiple freeze-thaw cycles.

For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.

QED Bioscience, Inc. Toll Free 800.929.2114 Visit our website for additional product 10919 Technology Place, Suite C Phone 858.675.2405 information and to order online. San Diego, CA 92127 Fax 858.592.1509 [email protected] qedbio.com