Ann. rheum. Dis. (1970), 29, 569 Ann Rheum Dis: first published as 10.1136/ard.29.5.569 on 1 September 1970. Downloaded from

Abstracts

This section is published in collaboration with Abstracts of World Medicine and Ophthalmic Literature, published by the British Medical Association, and also includes a great many which are specially commissioned for this Journal. They are divided into the following sections: Acute Rheumatism Other Forms of Arthritis Immunology and Serology Rheumatoid Arthritis Bone Diseases Biochemical Studies Still's Disease Non-articular Rheumatism, including Disk Therapy Osteoarthrosis Syndromes, Sciatica, etc. Surgery Spondylitis Pararheumatic (Collagen) Diseases Other General Subjects Gout Connective Tissue Studies At the end of each section is a list of titles of articles noted but not abstracted. Not all sections may be represented in any one issue.

Acute rheumatism published in the past, this is the first from Iran, and it emanates from the Pahlavi University School of Medical A Day Hospital for Children with Rheumatic Fever (Paediatric) Cardiology in Shiraz. The prevalence of SPAGNUOLO, M., GAVRIN, J., and RYAN, J. (1970) rheumatic fever over a 10-year period was found to be

Pediatrics, 45, 276 1 fig., 11 refs 0 5 per cent., which is higher than that currently reported by copyright. from most Western In the rheumatic disorders of children, as in other ill- countries. In forty episodes observed nesses, the amount of medical supervision needed de- amongst patients of an average age of 10 years, 45 had creases with time, although continued observation re- established carditis (64-5 per cent.), but very few de- mains desirable. The need to avoid the overuse of specia- veloped chorea. Of 55 patients totalling seventy hospital lized and expensive hospital facilities, has led to the admissions, eight died, a case fatality rate of 14-2 per establishment in several places of Day Hospitals, upon cent. No significant difference in socioeconomic status an experimental basis. This report is from the Irvington was detected between the rheumatic and control groups; House contrary to the widely held impression that the disease Day Hospital, New York, where the patients is more frequent in environments in which malnutrition, have the benefit of whatever medical attention and poverty, and overcrowding are prevalent. auxiliary services may be needed and can return home http://ard.bmj.com/ at night. W. S. C. COPEMAN The authors report on one hundred consecutive chil- Role of Tonsils in predisposing to Streptococcal Infections dren with acute rheumatic fever who attended during the and Recurrences of Rheumatic Fever FEINSTEIN, A. R., latter part of their illness at a time when they were able and LEvIrr, M. (1970) New Engl. J. Med., 282, 285 1 to tolerate near-normal activities. Most of them were fig., bibl. finally discharged shortly after discontinuation oftherapy, (see Abstr. Wld Med. (1970), 44, 454). although a few of the exceptions who are described had to be readmitted with clinical rebounds and other Indirect Immunofluorescence in the Serological Diagnosis on September 28, 2021 by guest. Protected residual disorders. of Streptococcal Diseases L. Application in Rheumatic The incidence of permanent heart disease in those Fever (L'immunofluorescenza indiretta nella diagnosi who attended the day hospital did not differ from that sierologica delle affezioni streptococciche. I. Utilizza- in children who had been subjected to full hospitalization zione nella malattia reumatica) CIAMPOLINI, M., for the entire duration of their illness. The authors con- FRANCHINI, F., and TREVISAN, C. (1969). Minerva clude that a long period of hospital care and convales- pediat., 21, 2431 4 figs, 43 refs cence is required only in that 5 per cent. of patients who (See Abstr. Wld Med., (1970) 44, 503.) have chronic rheumatic fever. The others who attended the Day Hospital were able to resume normal activities Decreasing Incidence of a History of Acute Rheumatic including schooling much sooner than if they had con- Fever inChronicRheumaticHeart Disease VENDSBORG, P., tinued as in-patients. W. S. C. COPEMAN FAUERHOLDT-HANSEN, L., and OLESEN, K. H. (1968) Cardiologia, 53, 332 2 figs, 22 refs Acute Rheumatic Fever in Shiraz, Iran GHARIB, R. (See Abstr. Wld Med. (1970), 44, 548). (1969) Amer. J. Dis. Child., 118, 694 24 refs Some Aspects of Epidemiology and Surveillance of Although reports upon the incidence of rheumatic Rheumatic Fever 9rrAj, S., URBANEK, T., and BO§MAN- fever in several of the Middle Eastern countries have been SKY, K. (1970) Acta rheum. scand., 16, 30 4 figs, 20 refs 570 Annals of the Rheumatic Diseases Ann Rheum Dis: first published as 10.1136/ard.29.5.569 on 1 September 1970. Downloaded from

Rheumatic Mitral Valvular Disease in the Adolescent. than in the control group. The authors conclude that Clinical Evaluation and Surgical Indications in 86 Cases most-but not all-heart disease found in rheumatoid (Valvulopatia mitral reumdtica del adolescent) MATA, arthritis patients is innocuous. W. S. C. COPEMAN M. L. A., SALOM6N, C. A., and ORDONqEZ, M. A. (1969) Arch. Inst. Cardiol. MWx., 39, 612 5 figs, 16 refs Rheumatoid Arthritis and the Xylose Tolerance Test Studies on the Serum Level of Neuraminic Acid in the GAMBLE, W. S., ABBRUZZESE, A., GRAY, S. J., and Course of Cardiac Failure in Children with Rheumatic BAYLES, T. B. (1969) Amer. J. Gastroent., 52, 445 2 figs, Fever [In Polish] SOWIN'SKA, J., and WOJTECKA, E. 36 refs (1969) Reumatologia (Warsz.), 7, 341 3 figs, 6 refs Among 35 patients with classical or definite rheumatoid arthritis, in whom there was no clinical evidence of Rheumatic Heart Disease Epidemiology. m. The San arteritis or amyloidosis and in whom renal function was Luis Valley Prevalence Study MORTON, W. E., WARNER, grossly normal, the 5-hour urine zylose was significantly A. L., WEIL, J. V., SHMOCK, C. L., JR., SNYDER, J., and reduced (below 6-2 g.) in eighteen, and in six of these LicHTY, J. A. (1970) Circulation, 41, 773 6 refs the serum zylose was raised. A low urine zylose was virtually restricted to females; it was not related to the Rheumatic Fever-1970 LUCKSTEAD, E. F., and DIEHL, titre of rheumatoid serum factor, nor explicable by the A. M. (1970) J. Kans. med. Soc., 71, 97 10 refs use of phenacetin. The authors consider these results to indicate renal impairment rather than intestinal malab- Criteria of Rheumatic Fever DAVIS (1970) Lancet, 1, sorption and suggest that the former may be commoner 1045 than is generally supposed. J. BALL Acute Rheumatic Fever in Virginia-Has it changed in the Last 20 Years? McCuE, C. M., ROBERTSON, L. W., Association of Rheumatoid Arthritis with Plasma Cell and ELDREDGE, W. J., and NOBLE, A. (1970) Virginia med. Lymphocytic Neoplasms GOLDENBERG, G. J., PARAS- Mth., 97, 273 5 figs, 6 refs KEVAS, F., and IsRAELs, L. G. (1969) Arthr. and Rheum. 12, 569-579 6 figs, 36 refs Acid-Base Equilibrium in the Treatment of Rheumatic (See Abstr. Wld Med. (1970), 44, 627) Fever in Children [In Polish] KORYCHA, A., PRONICKA, by copyright. E., JACOBSON, E., and KUBALSKA, J. (1970) Pediat. pol., 45, 413 3 figs, 19 refs Rheumatoid Arthritis, Dysproteinemic Arthropathy, and Paraproteinemia ZAWADZKI, Z. A., and BENEDEK, T. G. Renal Lesions in Rheumatic Heart Disease FAmmy, (1969) Arthr. and Rheum., 12, 555 2 figs, bibl. S. A. (1969) J. Egypt. med. Ass., 52, 524 11 figs, 9 refs (see Abstr. WId Med. (1970), 44, 628)

Transient Complete A-V Block in Two Siblings during Association between Rheumatoid Arthritis and in Acute Rheumatic Carditis in Childhood STOCKER et al. Total Populations [In English] HELLGREN, L. (1969) (1970) Pediatrics, 45, 850 Acta rheum. scand., 15, 316 Bibl. (see Abstr. WId Med. (1970), 44, 455) http://ard.bmj.com/ Rheumatoid arthritis Heart Disease in Patients with Sero-positive Rheumatoid Disturbance of Pulmonary Diffusing Capacity in Rheuma- Arthritis BONFIGLIO, T., and ATWATER, E. C. (1969) toid Arthritis and Systemic (Diffu- Arch. intern. Med., 124, 714 44 refs sionsstorungen bei primarchronischer Polyarthritis und Lupus erythematodes disseminatus) LODDENKEMPER, R., Pericarditis as an autopsy finding in 30 to 40 per cent. of BACH, G. L., and CARTON, R. W. (1970) Beitr. Klin. cases of chronic rheumatoid arthritis has been reported Erforsch. Tuberk., 141, 230 2 figs, 30 refs in many series since Charcot's paper in 1881 which (see Abstr. Wld Med. (1970), 44, 548) on September 28, 2021 by guest. Protected recorded-such a finding in four out of nine examinations. The present authors report detailed post mortem observations in 47 cases of seropositive rheumatoid Studies on the Sicca Syndrome in Patients with Rh toid arthritis and confirm these findings-in an equal number Arthritis ERICSON, S., and SUNDMARK, E. (1970) Acta of unmatched controls it was uncommon. Such lesions, rheum. scand., 16, 60 1 fig., 50 refs although almost always benign, are often associated (see Abstr. Wld Med. (1970), 44, 772) with electrocardiographic changes during life. They also appear to relate to long duration of the arthritis disease Problems of Caplan's Syndrome (Zur Problematik des and severe musculoskeletal disability. Constrictive peri- Caplan-Syndroms) MoRAwErz, F., and ScHNErz, E. carditis and rheumatoid granulomata, however, are (1970) Wien. med. Wschr., 120, 103 4 figs, 17 refs rarely found. Myocarditis was found most frequently in patients with severe . Coronary arteritis, when discovered, seemed to be only doubtfully relevant R atoid Lung Disease (Acute Articular Rh tis) to the rheumatic condition; functionally important (Pneumopathie rhumatismale (Rhumatisme articulaire valvular disease was rate. Non-specific endocarditis, aigu)) CARVALHAL, S. S., ATRA, E., SAAD, F. A., and although found to be quite common, was not more so Pupo, R. A. (1969) Rev. Rhum., 36, 597 9 figs, 15 refs Abstracts 571 Ann Rheum Dis: first published as 10.1136/ard.29.5.569 on 1 September 1970. Downloaded from

Chest Roentgenograms in Rheumatoid Arthritis: Hiro- Prevalence of Rheumatoid Arthritis in Densely and Thinly shima-Nagasaki NAKATA, H., and RUSSELL, W. J. (1970) Populated Areas in Sweden HELLGREN, L. (1970) Acta Amer. J. Roentgenol., 108, 819 5 figs, 11 refs rheum. scand., 16, 18 17 refs Pleuropulmonary Manifestations in Rheumatoid Arthritis Rheumatoid Disease: Rheumatoid Arthritis as a Systemic (Manifestaciones pleuropulmonares en la artritis reuma- Disease (La enfermedad reumatoidea. La artritis reuma- toidea) PIERoNI, P., LASALA, F., and GAGLIARDI, H. toidea como afeccion sist6mica) LASALA, F. G., and (1970) Pren. med. argent., 57, 73 10 figs, 11 refs PODESTA, H. A. (1970) Pren. mid. argent., 57 149

Unusual Pattern of Morphological Changes in Rheumatoid Clinical Picture of Cases of Rheumatoid Arthritis with Arthritis (Eine besondere morphologische Verlaufsform Rheumatoid Nodules [In Polish] MALDYK, H., and der primer chronischen Polyarthritis) JENTZSCH, K. SLOWINSKA, L. (1969) Reumatologia (Warsz.), 7, 333 (1970) Virchows Arch. path. Anat., 349, 244 8 figs, bible. 2 figs, 15 refs Microscopic Appearance of Baker's Cyst in Cases of Rheumatoid Arthritis WAGNER, T., and ABGAROWICZ, T. Choroidal Nodules and Retinal Detachments in Rheuma- (1970) Reumatologia (Warsz.), 8, 21 3 figs, 9 refs toid Arthritis. Improvement with Fall in Immunoglobulin Levels following Prednisolone and Cyclophosphamide Rib Lesions in Rheumatoid Disease JOHNSON et al. (1970) Therapy HURD et al. (1970) Amer. J. Med., 48, 273 Brit. J. Radiol, 43, 269 Rheumatoid Carditis KRA, S. J., and FAZZONE, P. Severe Subluxation of the Cervical Spine in Rheumatoid (1970) Conn. Med., 34, 257 10 refs Arthritis CRELLIN, R. Q., MACCABE, J. J., and HAMIL- TON, E. B. D. (1970) J. Bone Jt Surg., 52B, 244 7 figs, Rheumatoid Arthritis in the Aged EHRLICH, G. E., 14 refs KATZ, W. A., and COHEN, S. H. (1970) Geriatrics, 25, 103 2 figs, 15 refs Changes in the Cervical Vertebrae in Rheumatoid Arthritis (Veranderungen derHalswirbelsaule bei der rheumatoiden Arthritis) WEIGL, E., and WRUCK, E. (1969) Radiol. Rubella Infection of Synovial Cells and the Resistance of by copyright. diagn. (Berl.), 10, 655 4 figs, 16 refs Cells derived from Patients with Rheumatoid Arthritis GRAYZEL, A. I., and BECK, C. (1970) J. exp. Med., 131, Atlanto-axial Dislocation and Cervical Spondylodiscitis 367 1 fig., 16 refs in a Case of Rheumatoid Arthritis (Dislocation atloido- axoidienne et spondylodiscite cervicale au cours d'une Penicillamine and Rheumatoid Arthritis (Penicillamine et polyarthrite rhumatoide) CABANEL, G., PHELIP, X., and polyarthrite rhumatolde. (etude de 9 observations)) VERDiER, J.-M. (1970) Rev. lyon. Mid., 19, 173 8 figs, CAMUs et al. (1970) Ann. Med. intern., 121, 237 24 refs -a Little Known Disease in African Immigrants Types of Presentation of Rheumatoid Arthritis (Die Ers- to France. Association with Rheumatoid Arthritis in 2 http://ard.bmj.com/ cheinungsformen der chronischen Polyarthritis) SCHOEN, Cases (Une maladie peu connue: I'Ainhum. Son associa- R. (1970) Med. Welt (Stuttg.), 21, 753 12 refs tion a une polyarthrite rhumatolde. A propos de 2 cas) ARsov, D., KkivmnE, J.-M., and KAHN, M.-F. (1970) Tarsal-Tunnel Syndrome: a Presenting Feature ofRheuma- Rhumatologie, 22, 1 4 figs, 11 refs toid Arthritis LLOYD, K., and AGARWAL, A. (1970) Brit. med. J., 3, 32 8 refs Systemic Manifestations of Rheumatoid Arthritis and Allied Disorders SALES, L. M. (1970) Sth. med. J. (Bgham, Involvement of the Manubrio-Sternal Articulation in Ala.), 63, 543 on September 28, 2021 by guest. Protected Rheumatoid Arthritis LAITINEN, H., SAKSANEN, S., and SUORANTA, H. (1970) Acta rheum. scand., 16, 40 5 figs, Reversible Acute Renal Failure complicating Rheumatoid 8 refs Arthritis WEGELIUS, O., and KLocKARS, M. (1970) Acta rheum. scand., 16, 161 4 figs, 12 refs Microradiographic and Histological Study of the Manu- brio-Sternal Joint in Rheumatoid Arthritis KORMANO, M. Acta rheum. scand., Rheumatoid Arthritis: Extra-articular Manifestations. (1970) 16, 47 21 figs, 18 refs H. (Stanley Davidson Lecture, Aberdeen) HART, F. DUDLEY (1970) Brit. med. J., 2, 747 Positive Elbow Fat Pad Sign in Rheumatoid Arthritis JACKMAN, R. J., and PUGH, D. G. (1970) Amer. J. Roentgenol., 108, 812 7 figs, 11 refs Still's disease Terminology of Rheatoid Arthritis (Review) (Die 'Pseudorheumatoid' Nodules in Children: Report of 10 Terminologie der primar chronischen Polyarthritis) Cases BURRINGTON, J. D. (1970) Pediatrics, 45, 473 MATHIES, H. (1970) KIln. Wschr., 48, 513 7 refs 5 figs, 6 refs 572 Annals of the Rheumatic Diseases Ann Rheum Dis: first published as 10.1136/ard.29.5.569 on 1 September 1970. Downloaded from

Pituitary and Adrenal Functional Reserve in Children Spondylitis with Rheumatoid Arthritis [In Polish] W6JcIK, T., and BARTKIEWICZ, H. (1969) Reumatologia (Warsz.), 7, Ankylosing Spondylitis CALABRO and MALTZ (1970) 347 26 refs New Engl. J. Med., 282, 606 Radiological Diagnosis of Juvenile Rheumatoid Arthritis Ankylosing Spondylitis and Rheumatoid Arthritis Hus- (Rontgendiagnostik der juvenilen Rheumatoid-Arthritis) KISSON, E. C. (1970) Proc. roy. Soc. Med., 63, 620 LORENZ, K., and BERGER, G. (1969) Radiol. diagn. (Berl.), 10, 647 9 figs, 18 refs Ankylosis in the Paralysed Patient WHARTON, G. W., and MORGAN, T. H. (1970) J. Bone Jt Surg., 52-A, 105 4 Acid Phosphatase Activity in the Synovial Fluid of Children figs, 14 refs with Juvenile Rheumatoid Arthritis BECKMAN, G., BECKMAN, L., GoumFoRs, L., and LEMPERG, R. (1970) Acetabular Labrum in Ankylosing Spondylitis (Le bour- Acta paediat. scand., 59, 205 3 refs relet cotyloidien dans la spondylarthrite ankylosante) (see Abstr. Wid Med. (1970), 44, 696) LOUYOT, P., GRAFF, J.-R., JUNG, G., and MONTET, Y. (1969) Rev. Rhum., 36, 569 5 figs On the Etiology of Growth Disturbance of the Mandible in Juvenile Rheumatoid Arthritis SAIRANEN, E. (1970) Atypical Forms of Ankylosing Spondylitis [An Analysis of Acta rheum. scand., 16, 136 5 figs, 28 refs 236 Cases] (Les formes atypiques de la spondylarthrite ankylosante (A propos de l'analyse de 236 observations)) RAVAULT, P.-P., LEJEUNE, E., BOUVIER, M., JEANNERET, J., MEUNIER, P., QUENEAU, P., and ROBILLARD, J. (1970) Osteoarthrosis Rev. Rhum., 37, 197 8 figs, 41 refs Generalized Osteoarthrosis in a Population Sample Contribution of Electromyography of the Diaphragm to LAWRENCE, J. S. (1969) Amer. J. Epidemiol., 90, 381 the Study of the Dynamic Respiratory Reflexes in Anky- 2 figs, 1 ref. losing Spondylitis (Contribution de l'electromyographie (see Abstr. WId Med. (1970), 44, 455) du diaphragm a l'etude des reflexes respiratoires

dynamiques dans la spondylarthrite ankylosante) DEL- by copyright. Rapidly Destructive Osteoarthritis of the Hip (La coxar- HEZ, L., PIRNAY, F., BARZIN, J., and PETIT, J. M. (1969) throse destructrice rapide) LEQuEsNE, M. (1970) Rhuma- refs tologie, 22, 51 10 figs, 10 refs J. beige Rhum. Mid. phys., 24, 209 1 fig., 17 Osteoarthritis of the Hip in Rheumatological Practice in Lebanon (La coxarthrose en pratique rhumatologique au Liban) BITAR, E. (1970) J. mid. liban., 23, 69 17 refs Gout Bone Factor in Chronic Disease of the Hip Joint (Le fac- Uric Acid and Plasma Lipids in Cerebrovascular Disease. teur osseux dans les coxopathies chroniques) MEUNIER, Part L. Prevalence of Hyperuricaemia PEARCE, J., and AzIz, H. (1969) Brit. med. J., 4, 78 P., VIGNON, G., and RAVAULT, P.-P. (1970) J. Mid. Lyon, http://ard.bmj.com/ 51, 375 9 figs, 13 refs Of sixty patients with cerebrovascular episodes, fourteen were found to have sustained hyperuricaemia. It is Significance of the Magnitude of the Medial Hip Joint therefore suggested that hyperuricaemia may be a pre- Space ANDERSON, J., and STEWART, A. M. (1970) Brit. disposing factor to atheroma. J. Radiol., 43, 238 7 refs [The definition of hyperuricaemia-values above 7 mg./ 100 ml. in males and 6 mg./100 ml. in females-was Carpometacarpal Osteo-Arthritis of the Thumb SIMs, obtained after reference to an undefined control group of 422 C. D., and BENTLEY, G. (1970) Brit. J. Surg., 57, 200 subjects. Comparison of the two populations was on September 28, 2021 by guest. Protected 13 figs, 6 refs not made by the proper statistical method and interpre- tation of the study is therefore slightly unsatisfactory.] Subluxation of the Carpal Scaphoid ENGLAND (1970) J. T. SCOTT Proc. roy. Soc. Med., 63, 581 Part H. Uric Acid-Plasma Lipid Correlations PEARCE, J., and Azrz, H. (1970) J. Neurol. Neurosurg. Psychiat., 33, Osteoarthritis and with Multiple Foci in the 88 Course of Septicaemia due to 'Reading' Salmonella complicating Sickle-cell Thalassaemia (Ost oarthrite et Blood from sixty patients with cerebrovascular disease osteite a foyers multiples au cours d'une septickmie a was examined with reference to uric acid, cholesterol, Salmonella 'Reading' compliquant une thalasso-drepano- free fatty acids, triglycerides, and phospholipids. To cytose) DOURY, P. (1970) Rev. Rhum., 37, 359 determine whether these results were abnormal, the per- centage of subjects having levels over the estimated Arteriographic Investigation of the Hip in Adult Human normal 95th percentile was compared with the estimated Subjects: A Clinical Study of the Arteries in the Healthy 5 per cent. of normals, normal figures being obtained Hip, in Neck and Pertrochanteric Fractures, and in from published sources. It was concluded that the patients Necrosis of the Femoral Head MUSSBICHLER (1970) showed raised levels of all the lipid fractions, especially in Acatos cartho p.nd., Suppl. 132 respect of triglycerides. All the lipid fractions tended to Abstracts 573 Ann Rheum Dis: first published as 10.1136/ard.29.5.569 on 1 September 1970. Downloaded from be elevated together, but these changes did not correlate Gout TALBOTT, J. H. (1970) Med. Clin. N. Amer., 54, with hyperuricaemia. 431 [The study and its interpretation would have been facili- tated by the inclusion of a control group.] J. T. SCOTT Manifestations of Gout in the Hip (Manifestations de la goutte i la hanche) QUEROL, J. R., and GOMEZ, J. M. Effect of Colchicine on Human Platelet Behaviour (1970) Rhumatologie, 22, 77 2 figs, 4 refs Sopprrr, G. D., and MITCHELL, J. R. A. (1969) J. Athero- Gout and Myxoedema (Goutte et myxoed me) RUBENS- scl. Res., 10, 247 4 figs, 17 refs DUVAL, A., KAPLAN, G., and PANAHI, F. (1970) Rev. Because of the capacity of colchicine to combine with Rhum., 37, 333 6 refs microtubules, it has been found to inhibit clot retraction. The present investigation from the Department of Medi- Dynamics of Metabolism in Gout (Dynamik des Stoff- cine, Nottingham University, extends this observation to wechsels bei Gichtkranken) MERTZ, D. P., PRASSE, D., other aspects of platelet behaviour. and KLOPFER-ZAAR, M. (1970) Med. Kin., 65, 790 3 The effect of colchicine in various concentrations on figs, 49 refs platelet aggregation produced by ADP, by nor-adrena- line, and by a connective tissue preparation ('collagen') Circadian Rhythm of Uricaemia (Ritmo circadiano en la was tested in vitro. In each instance, platelet aggregation uricemia) DE MORO, E. R., and DE DAHINTEN, N. M. was inhibited, the degree of inhibition varying with the (1970) Pren. mid. argent., 57, 241 2 figs, 27 refs concentration of colchicine. Colchicine was also shown to diminish platelet adhesiveness. By the use of -SH Renal Excretion of Uric Acid in Various Conditions inhibitors it was demonstrated that the action of colchi- causing Hyperuricaemia (L'escrezione renale dell'acido cine was probably not due to -SH blockade. By the use of urico in diverse condizioni iperuricemizzanti) CAGLI, an acetylated analogue of colchicine it was further shown V., RuOTOLO, V., BOSsINI, A., and BOLOGNA, E. (1970) that the inhibition of platelet aggregation by colchicine Policlinico, Sez. prat., 77, 245 7 refs was not due to the presence of an acetyl group. It is concluded that, because of its capacity to inhibit Renal Function Studies with Radioisotopes in Gouty platelet retraction, aggregation, and adhesiveness, col- Arthritis (Nierenfunktionsuntersuchungen mit Radio- by copyright. chicine may modify some fundamental property of plate- isotopen bei Arthritis urica) WASCHER, H., KLEIN, G., lets, perhaps related to their microtubular/contractile EBER, O., HAYN, H., and GOEBEL, R. (1970) Z. Rheuma- protein system. D. L. GARDNER forsch., 29, 85 4 figs, 15 refs

Intestinal Malabsorption induced by Oral Colchicine. Genetics of Gout and Hyperuricemia BAYANI-SIOSON, Comparison with Neomycin and Cathartic Agents RACE, P. S., ZAFRA, R. G., and BELTRAN, L. (1969) Acta med. T. F., PAES, 1. C., and FALOON, W. W. (1970) Amer. J. philipp., 6, 48 2 figs, 10 refs med. Sci., 259, 32 4 figs, 18 refs (See Abstr. Wid Med., (1970) 44, 587) Hyperuricemia and Neurologic Deficits: A Family Study

ROSENBERG et al. (1970) New Engl. J. Med., 282, 992 http://ard.bmj.com/ Treatment of Gout with Thiopurinol (with Reference to 50 Cases) (Traitement de la goutte par le Thiopurinol Hyperuricaemia in Northern Finland ISOMAKI, H. (1969) (A propos de 50 observations)) SERRE, H., SIMON, L., Ann. clin. Res., Suppl. 1 to Vol. 1 and CLAUSTRE, J. (1969) Rhumatologie, 21, 319 4 figs, 4 refs Calcium Pyrophosphate Crystal Synovitis with Articular (See Abstr. WId Med. (1970), 44, 456) Chondrocalcinosis ('Pseudogout' Syndrome) WEBB, J., CHAMPION, D. G., FRECKER, A. S., and ROBINSON, R. G. Liver Involvement in Gout (Leberbeteiligung bei Gicht) (1970) Med. J. Aust., 1, 466 26 figs, 21 refs on September 28, 2021 by guest. Protected HENNECKE, A., and SiYDHOF, H. (1970) Dtsch. med. Wschr., 95, 59 3 figs, 17 refs Disorder of Purine Metabolism due to Partial Deficiency (See Abstr. Wid Med. (1970), 44, 456) of Hypoxanthine-Guanine Phosphoribosyltransferase KoGUT, M. D., DONNELL, G. N., NYHAN, W. L., and Current Problems of Gout (Aktuelle Gichtprobleme) SWEETMAN, L. (1970) Amer. J. Med., 48, 148 10 figs, THIELE, P., HEIDELMANN, G., GXRTNER, A., SCHNEIDER, 57 refs V., and TELLKAMP, F. (1970) Z. ges. inn. Med., 25, 458 82 refs Enzymopathic Types of Gout. Disorders of Purine Meta- bolism due to Deficiency of Hypoxanthine-Guanine Sacroiliac Gout associated with Hemoglobin E and Hyper- Phosphoribosyltransferase. Frequency and Clinical Charac- splenism LAMBETH, J. T., BURNS-COX, C. J., and teristics of the Enzyme Deficiency (Gouttes enzymo- MACLEAN, R. (1970) Radiology, 95, 413 2 figs, 13 refs pathiques. Dyspurinies par deficit en hypoxanthine- guanine phosphoribosyltransferase. Frequence et carac- Radiological Appearance of the Spine in Gouty Patients teres cliniques de l'anenzymose) DELBARRE, F., CARTIER, [In Polish] KAWENOKI-MINC, E., and ZABOKRZYCKI, J. P., AUSCHER, C., GtRY, A. DE, and HAMET, M. (1970) 1969) Reumatologia (Warsz.), 7, 325 2 figs, 15 refs Presse mid., 78, 729 4 figs, 10 refs 574 Annals of the Rheumatic Diseases Ann Rheum Dis: first published as 10.1136/ard.29.5.569 on 1 September 1970. Downloaded from

Clinical Trial of L2214 in the Treatment of Gout or It is suggested that arteries other than the temporal Rheumatological Syndromes associated with Hyperuri- artery can be involved by a giant-cell arteritis, that this caemia (Essai clinique du L2214 dans le traitement de la is more frequent than has been previously supposed, and goutte ou des syndromes rhumatologiques associes a that as in the present case the involvement of other une hyperuric6mie) BOGAERT, PH. VAN (1969) J. beige arteries may dominate the clinical picture. Rhum. Mid. phys., 24, 295 1 fig, 5 refs H. A. SISSONS Hypouricaemic and Uricosuric Action of Benziodarone (Sull'azione ipouricemizzante ed uricosurica del benzio- Chondrocalcinosis and Arthropathy: Studies in Haemo- darone) TADDEUCCI, E., and TERRENI, F. (1970) Minerva chromatosis and in Idiopathic Chondrocalcinosis ATKINS, med., 61, 1771 25 refs C. J., McIvoR, J., SMITH, P. M., HAMILTON, E., and WILLIAMS, R. (1970) Quart. J. Med., 39, 71 10 figs, 31 Benziodarone in the Treatment of Hyperuricaemis (II refs benziodarone nel trattamento delle iperuricemie) RAVERA, M. (1970) Clin. ter., 52, 407 5 figs, 24 refs The arthropathy associated with chondrocalcinosis has been compared in twenty patients with haemochromatosis Colchicine Plasma Levels. Implications as to Pharma- and forty with idiopathic chondrocalcinosis at King's cology and Mechanism of Action WALLACE et al. (1970) College Hospital. In the idiopathic group, osteoarthritis Amer. J. Med., 48, 443 affecting the lumbar spine, hips, and knees was commonly found. In the haemochromatosis group, a specific arthro- Prevention of Hyperuricemia by Allopurinol in Hyperten- pathy, mainly affecting the metacarpophalangeal joints, sive Patients treated with Chlorothiazide NICOTERO et was present in sixteen, superficially resembling rheuma- al. (1970) New Engl. J. Med., 282, 133 toid arthritis, but without synovial thickening. X-ray examination showed small cysts in the matacarpal heads, Significance of the Deficiency State in Lesch-Nyhan followed by degenerative changes but without any Disease GHADIMI et al. (1970) Acta paediat. scand., 59, marginal erosions of rheumatoid arthritis. Osteoarthritic 233 changes were also found in the elbows, shoulders, hips, and knees. Acute episodes of crystal synovitis were Influence of Adenine on the Clinical Features and Purine equally frequent in either group, most commonly affect- by copyright. Metabolism in the Lesch-Nyhan Syndrome VAN DER ZEE ing the knee. Synovial biopsy revealed calcium pyro- et al. (1970) Acta paediat. scand., 59, 259 phosphate crystals in six of 24 in the idiopathic group, but in none of seven with haemochromatosis, although Dins of Lesch-Nyhan Syndrome by Skin Specimens iron deposits were identified in two of these. Fibrocarti- FROsT et al. (1970) J. Amer. med. Ass., 212, 316 lage calcification was similar in the two groups, but hyaline cartilage calcification was significantly more common with haemochromatosis, and there was a correlation between the degree of calcification and the severity of arthropathy in this group, but not in the Other forms of arthritis idiopathic group. A. B. MYLES http://ard.bmj.com/ Rhizomelic Pseudopolyarthritis with Temporal Arteritis and Arteritis of the Lower Limbs (Pseudo-polyarthrite Articular Chondrocalcinosis and Rheumatoid Arthritis rhizom6lique de l'art6rite temporale a l'arterite des (Chondrocalcinose articulaire et polyarthrite chronique membres inf6rieurs) BASTIN, R., GODEAU, P., LAVERNHE, evolutive) SAPORTA, L., AMOR, B., GUIRAUDON, C., J., LEGER, L., and LEMAIGRE, G. (1969) Presse mid., 77, BoNToux, D., HILA, A., MASSIAS, P., and DELBARRE, F. 1649 3 figs, 16 refs (1969) Rev. Rhum., 36, 647 9 figs, 19 refs (See Abstr. WId Med. (1970), 44, 628)

A review of temporal arteritis and its association with on September 28, 2021 by guest. Protected arteritis of the lower limbs and with rheumatism, with a report of one case. Primary Chondrocalcinosis Articularis. Its Relation to The patient was a woman aged 60 years, with scapular Sex, Age at Onset, and (Chondrocalcinose and pelvic pain, fever, leucocytosis, anaemia with in- articulaire primaire. Ses rapports avec le sexe des creased sedimentation rate, and changes in the plasma malades, l'age des patients au debut de l'affection, le proteins. She developed of the legs, requiring diabete) RADI, I., AMOR, B., BROUILHET, H., DELBARRE, bilateral amputation. Histological examination of the F., and MARTIN, E. (1970) Rev. Rhum., 37, 263 188 refs main arteries of the legs showed giant-cell arteritis of the type seen in temporal arteritis, although biopsy of the right temporal artery failed to show any histological Articular Chondrocalcinosis and the Problem of Patho- abnormality. In the affected vessels the media was in- genesis (La chondrocalcinose articulaire et son myst~re filtrated with lymphocytes and other inflammatory cells: pathogenique) SOLNICA (1970) Presse med., 78, 873 the intima showed fibrous thickening with obliteration of small vessels: the internal elastic lamina was destroyed by granulomatous inflammatory tissue containing giant Rheumatic Lesions of the Sacroiliac Joint [In Dutch] cells. Atheromatous changes were not present. Treatment BLACOURT, J. J. DE, and BLICKMAN, J. R. (1970) Ned. T. with corticosteroid hormones was effective. Geneesk., 114, 413 9 figs, 2 refs Abstracts 575 Ann Rheum Dis: first published as 10.1136/ard.29.5.569 on 1 September 1970. Downloaded from

Familial Coexistence of Chronic Rheumatic inflammatory Non-Traumatic Necrosis of the Femoral Head. Part I. Polyarthropathies and Involvement of the Sacroiliac Relation of Altered Hemostasis to Etiology BoETrcHER, Joints (Coexistence familiale de polyarthropathies W. G., BONFIGLIO, M., HAMILTON, H. H., SHEETS, R. F. inflammatoires chroniques rhumatismales avec atteinte and SMITH, K. (1970) J. Bone Jt Surg., 52A, 312 des articulations sacro-iliaques) FALLET, G.-H., MEYER, Part II. Experiences in Treatment BOETrCHER, W. G., E., Orr, H., and RADI, I. (1970) Rev. Rhum., 37, 213 18 BONFIGLIO, M., and SMITH, K. (1970) J. Bone Jt Surg., figs, 28 refs 52A, 322 Gonorrhoea with Skin and Joint Manifestations WOLFF Possible Role of Fat Embolism in the Pathogenesis of et al. (1970) Brit. med. J., 1, 271 Idiopathic Necrosis of the Femoral Head (Zur moglichen Rolle der Fettembolie in der Pathogenese der idio- Diabetic Arthropathy [In Swedish] AMTRUP, F. (1970) pathischen Femurkopfnekrose) ScHmID, U., HARTMANN Nord. Med., 83, 627 4 figs, 9 refs G., MORSCHIER, E., and ELKE, M. (1970) Schweiz. med. Wschr., 100, 820 2 figs, 28 refs Septic Arthritis due to Vibrio fetus KUTNER, L. J., and ARNOLD, W. D. (1970) J. BoneJt Surg., 52-A, 161 2 figs, Hydroxyprolinuria in (L'hydroxyprolinurie 11 refs au cours des affections osseuses) LEJEUNE, E., RUmrION, P., MEUNIER, P., and ORGIAZZI, J. (1970) J. Med. Lyon, Ochronotic Arthropathy DETENBECK, L. C., YOUNG, 51, 385 17 refs H. H., and UNDERDAHL, L. 0. (1970) Arch. Surg., 100, 215 5 figs, 15 refs Bilateral Talar Dissecans with Lax Ankle Ligaments DAVIS, M. W. (1970) J. Bone Jt Surg., Investigations into the Hereditability of Psoriatic Arthro- 52-A, 168 2 figs, 10 refs pathy (Untersuchungen uber die Vererblichkeit des Syndroms Psoriasis arthropathica) VILAGHY, I., and Vertebral and Diabetes Mellitus (Hyperos- KREBS, A. (1970) Dermatologica (Basel), 140, 209 8 refs tose vertebrale et diabe'e sucre) LEQuEsNE, M., CASSAN, P., NALLET, J., RYCKEWAERT, A., and StZE, S. DE (1970) Rev. Rhum., 37, 281 3 figs, 14 refs Intrafamilial Investigations in Psoriatic Arthritis (Intra- by copyright. familiare Untersuchungen bei Psoriasis-Arthritis) THEIss, B., SCHNYDER, U. W., BONI, A., and WAGEN- HXUSER, F. (1969) Z. Rheumaforsch., 28, 403 2 figs, 103 Non-articular rheumatism refs Analysis of Cauda Equina Symptoms in Patients with Lumbar Disc Prolapse AHO, A. J., AURANEN, A., and Arthritis complicating Rubella SMITH and GUZOWSKA PESONEN, K. (1969) Acta chir. scand., 135, 413 1 fig, (1970) Med. J. Aust., 1, 845 36 refs Pseudoxanthoma Elasticum [PXE] and Joint Manifesta- There have been nineteen cases between 1963 and 1966 at the Department of Surgery, Turku University, in

tions SAIRANEN, E., ITKONEN, A., and KANGAS, S. http://ard.bmj.com/ (1970) Acta rheum. scand., 16, 130 2 12 refs which a patient with lumbar disc prolapse has also had figs, urinary symptoms for from 1 to 7 days. This study is principally concerned with eighteen such patients treated by immediate surgery: this group is compared with Bone disease another 98 patients operated upon during the same period for uncomplicated lumbar disc prolapse. Most Secondary Hyperparathyroidism in patients had a short history of dorsal pain radiating to THALASSINOS, N. C., WicHT, S., and JOPLIN, G. F. the extremities. The straight-leg raising test was positive (1970) Brit. med. J., 1, 76 3 figs, 29 refs and there was some loss of sensation in all patients: the on September 28, 2021 by guest. Protected (See Abstr. WId Med. (1970), 44, 603) residual urine exceeded 500 ml. in fifteen patients. Follow- up examinations were made in seventeen cases at from 6 mths to 3 yrs after operation. Motor and sensory Hypocalcaemic Primary Hyperparathyroidism KEYNES, disturbances showed little change. Mild urinary symp- W. M., and CAIRD, F. I. (1970) Brit. med. J., 1, 208 toms were present in about 30 per cent. of cases. Urinary 1 fig., 45 refs function was studied by cystometry: an atonic bladder (See Abstr. WId Med. (1970), 44, 449) was present in about 70 per cent., but the residual urine exceeded 10 ml. in only 25 per cent. and none had Treatment of Paget's Disease of Bone by Radiotherapy ureteral reflux. All patients were at work after 6 months, LEVISON, V. (1970) Ann. phys. Med., 10, 230 13 refs but some had to change to lighter occupations. (See Abstr. WId Med. (1970), 44, 576) A. J. PALFREY Aseptic Necrosis of the Femoral Head (La necrose asep- Predictive Value of Myelography in the Diagnosis of tique de la tete femorale) LAGIER, R., MARTIN, E., Ruptured Lumbar Discs HUDGINS, W. R. (1970) J. and RADI, I. (1970) Schweiz. med. Wschr., 100, 814 4 Neurosurg., 32, 152 2 figs, 26 refs figs, 21 refs (See Abstr. WId Med., (1970) 44, 654) 576 Annals of the Rheumatic Diseases Ann Rheum Dis: first published as 10.1136/ard.29.5.569 on 1 September 1970. Downloaded from

Effects of Torsion on the Lumbar Intervertebral Joints: Studies of Articular Cartilage following Infarction of the The Role ofTorsion in the Production ofDisc Degeneration Capital Femoral Epiphysis in the Puppy ZAHIR et al. FARFAN, H. F., CossEITE, J. W., ROBERTSON, G. H., (1970) Proc. roy. Soc. Med., 63, 583 WELLS, R. V., and KRAUS, H. (1970) J. Bone Jt Surg., 52-A, 468 22 figs, 32 refs Articular Cartilage Changes in Early Arthritis JANIS, R., ardd HAMERMAN, D. (1969) Bull. Hosp. Jt Dis. (N. Y.), 30, Aetiology of Juvenile Spondylarthritis [Discitis] ALEX- 136 3 figs, 33 refs ANDER, C. J. (1970) Clin. Radiol, 21, 178 11 figs, 34 refs Effect of Polysaccharides on the Water-binding Capacity of Collagen (Die Beeinflussung der Wasserbindungs- kapazitat von Kollagen durch Glykosaminoglykane) Cervical Spondylosis with Radioculopathy JACOBS, B., WEIGEL, W., JASINSKI, B., and IWANGOFF, P. (1969) KRUEGER, E. G., and LEIWY, D. M. (1970) J. Amer. med. Z. Rheumaforsch., 28, 429 1 fig., 10 refs Ass., 211, 2135 3 figs, 14 refs Urinary Polypeptides related to Collagen Synthesis Lumbo-Sacral Strain Syndrome INGPEN, M. L., and KRANE, S. M., MUfqOZ, A. J., and HARRIS, E. D., JR. BURRY, H. C. (1970) Ann. phys. Med., 10, 270 8 refs (1970) J. clin. Invest., 49, 716 8 figs, 44 refs

Effect of Spinal Supports on the Electrical Activity of Consideration of Pathogenesis of Rheumatoid Arthritis as Muscles of the Trunk WATERS, R. L., and MORRIS, J. M. Collagen Autoimmunity STEFFEN, C. (1970) Z. Immun.- (1970) J. Bone Jt Surg., 52-A, 51 5 figs, 13 refs Forsch., 139, 219 1 fig., 37 refs Histological Observations on Experimentally-induced Low-Frequency Therapy with Interference Current in Degeneration of Articular Cartilage THOMPSON, R. C., Scapulo-humeral Periarthritis (Niederfrequenztherapie and BASSETT, C. A. L. (1970) J. Bone Jt Surg., 52-A, 435 mit Interferenzstrom bei Periarthritis humeroscapularis) 7 figs, 11 refs NIKOLOVA, L. (1970) Munch. med. Wschr., 112, 472 12 refs Experimental Study of the Effects of Growth on the

Relationship of Tendons and Ligaments to Bone at the by copyright. Dimethyl Sulphoxide in the Treatment of Scapulo- Site ofDiaphyseal Insertion VIDEMAN (1970) Acta orthop. humeral Periarthrosis [In Danish] RASMUSSEN, G., scand., Suppl. 131 ANDERSEN, R. B., and SCHLEDERMANN (1970) Ugeskr. Laeg., 132, 832 5 refs Tendon and Ligament Insertion. A Light and Electron Microscopic Study COOPER, R. R., and MISOL, S. Electromyography in the Tarsal Tunnel Syndrome (L'6lec- (1970) J. Bone Jt Surg., 52 A, 1 13 figs, 76 refs tromyographie du syndrome du tunnel tarsien) SkZE, S. DE, DREYFus, P., DENIS, A., HAMONET, Cl., HEULEU, Periarticular Microscopic Changes in Bones in Rheuma- J.-N., and LEGEAY, A. (1970) Rev. Rhum., 37, 189 2 figs, toid Arthritis [In Polish] MALDYK, E. (1969) Reumato- 27 refs logia (Warsz.), 7, 281 5 figs, 16 refs http://ard.bmj.com/ Calcifying Tendinitis (Tendinites calcifiantes) SiZE, S. Ultrastructure of Dermal Lesions in Systemic Lupus DE, and WELFLING, J. (1970) Rhumatologie, 22, 45 2 refs Erythematosus GRISHMAN, E., and CHURG, J. (1970) Lab. Invest., 22, 189 11 figs, 21 refs Acute Tendinitis Calcarea HAUPTMAN, H. A. (1970) Arthrography of the Ankle MEHREZ, M., and EL N. Y. St. J. Med., 70, 955 5 figs, 18 refs GENEIDY, S. (1970) J. Bone Jt Surg., 52-B, 308 11 figs, 16 refs Localization of Calcific Deposits in the Shoulder VIGARO on September 28, 2021 by guest. Protected and KEATS (1970) Amer. J. Roentgenol., 108, 806 Microscopic Appearance of Synovia in Cases of Rheuma- toid Arthritis [In Polish] WAGNER, T. (1969) Rheumato- logia (Warsz.), 7, 295 4 figs, 28 refs Cultures of the Synovial Membrane Lining Cells [In Connective tissue studies Polish] ABGAROWICZ, T., and KoZIoRowSKA, J. (1969) Reumatologia (Warsz.), 7, 291 1 fig., 6 refs Collagen Blundle Regulation and Control [Biocybernetics] DE CAMPOS VIDAL, B. (1969) Rev. bras. Pesq. med. biol., Characteristic Changes in Esterase and Peroxydase Iso- 2, 356 1 fig., 12 refs enzymes in the Synovial Tissue in Rheumatoid Arthritis (Ober charakteristische Unterschiede von Esterase-und Regulation of Collagen and Hyaluronate Formation in Peroxydase-Isoenzymen in synovialem Gewebe bei Human Synovial Fibroblast Cultures CASTOR, C. W., progressiv chronischer Polyarthritis) EBERL, R., and RowE, K., DORSEWITZ, E. L., WRIGHT, D., and RrrcHiE, ALTMANN, H. (1970) Z. Rheumaforsch., 29, 98 3 figs, J. C. (1970) J. Lab. clin. Med., 75, 798 6 figs, 23 refs 8 refs Abstracts 577 Ann Rheum Dis: first published as 10.1136/ard.29.5.569 on 1 September 1970. Downloaded from

P Phenomenon in Synovial Fluid (Das P-Phanomen in Acute Myositis of the Extraocular Muscles and Erythema der Synovialflissigkeit) KOTZ, R., CHLUD, K., and Nodosum SACHS, W., MANDEL, D., and COHEN, E. FRIZA, B. (1969) Z. Rheumaforsch., 28, 425 1 fig., 10 (1969) Harefuah, 77, 239 refs (See Ophthal. Lit., vol. 23)

Lubrication of Synovial Joints: Possible Significance of Myxovirus Antibody Increases in Human Connective Fat FREEMAN et al. (1970) Proc. roy. Soc. Med., 63, Tissue Disease PHILLIPS, P. E., and CHRISTIAN, C. L. 579 (1970) Science, 168, 982 22 refs

Malignant Synovioma KOGSTAD, 0. (1970) Acta rheum. Skin Involvement in Autoimmune Diseases and Colla- scand., 16, 81 7 figs, 16 refs genoses (Hautbeteiligung bei Autoaggressionskrankheiten und Kollagenosen) HOFMANN, N. (1970) Med. Welt Studies of the Third Component of Complement in Syno- (Stuttg.), 21, 415 12 refs vial Fluid from Arthritis Patients. II. Conversion and its Relation to Total Complement HEDBERG et al. (1970) Cardiac Involvement in Collagen Diseases (Herzerkran- Clin. exp. Immunol., 6, 707 kungen bei Kollagenosen) KROScH, H., SCHABITZ, J., and RIKIRSCH, P. (1970) Z. ges. inn. Med., 25, 424 3 Plasma Kinins in Synovial Exudates EISEN, V. (1970) figs, 65 refs Brit. J. exp. Path., 51, 322 3 figs, 19 refs Connective Tissue Disease following Anti-Epileptic Therapy DANO, P. (1969) Epilepsia (Amst.), 10, 481 19 refs Pararheumatic (collagen) diseases Involvement of the Eyes in Collagen Diseases (Augen- Reserpine in Raynaud's Disease and Phenomenon. Short- beteiligungen bei Kollagenosen) MEYTHALER, H. (1970) term Response to Intra-arterial Injection WILLERSON, Med. Welt (Stuttg.), 21, 1018 9 refs J. T., THOMPSON, R. H., HOOKMAN, P., HERDT, J., and

DECKER, J. L. (1970) Ann. intern. Med., 72, 17 11 figs, Double Vision and Temporal Arteritis MARTIN, E. A. by copyright. 25 refs (1970) J. Irish med. Ass., 63, 191 6 refs (See Abstr. WId Med. (1970), 44, 526) Takayasu's Syndrome and Lupus Disease (Syndrome de Scleredema and Diabetes Mellitus FLEISCHMAJER, R., Takayasu et maladie lupique) SIGUIER et al. (1970) FALUDI, G., and KROL, S. (1970) Arch. Derm., 101, Ann. Med. intern., 121, 531 21 3 figs, 16 refs (See Abstr. WId Med. (1970), 44, 559) Articular Manifestations of Takayasu's Disease (Les manifestations articulaires de la maladie de Takayasu) 'Rheumatoid' Nodules in Systemic Lupus Erythematosus SERRE, H., SIMON, L., and LAMBOLEY, C. (1970) Sem. HAHN, B. H., YARDLEY, J. H., and STEVENS, M. B. (1970) H6p. Paris, 46, 1587 5 figs, bibl. http://ard.bmj.com/ Ann. intern. Med., 72, 49 5 figs, 8 refs (See Abstr. WId Med. (1970), 44, 548) Cytotoxic Serum Factor in Polyarteritis Nodosa and Related Conditions YUST et al. (1970) Amer. J. Med., Neurologic Manifestations in Progressive Systemic 48, 472 Sclerosis GORDON, R. M., and SILVERSTEIN, A. (1970) Arch. Neurol., 22, 126 44 refs (See Abstr. Wid Med. (1970), 44, 548) Polyarteritis Nodosa of the Gallbladder REMIGIO, P., and ZAINO, E. (1970) Surgery, 67, 427 6 figs, 8 refs on September 28, 2021 by guest. Protected Sjogren's Syndrome in Relation to Pernicious Anaemia and Idiopathic Addison's Disease WILLIAMSON, J., Proliferative Myositis HEYDEN et al. (1970) Acta path. PATERSON, R. W. W., MCGAVIN, D. D. M., GREIG, W. R., microbial. scand., 78A, 33 and WHALEY, K. (1970) Brit. J. Ophthal., 45, 31 35 refs (See Ophthal. Lit., vol. 24) SjOgren's Syndrome and Renal Tubular Acidosis SHioJI et al. (1970) Amer. J. Med., 48, 456 Perforating Scleromalacia and Collagenous Disease (Scleromalacia perforante et collagenose) FRANCOIS, J., Familial with Sj6gren's Syndrome and VICTORIA-TRONCOSO, V., HASsNENS, M., and BACAKULIN, Lymphocytic and Chromosomal Abnormality (Sclero- J. (1969) Ophthalmologica (Baset), 159, 71 13 figs, bibl. dermie familiale avec syndrome de Sjogren et anomalies (See Ophthal. Lit., vol. 23) lymphocytaires et chromosomiques) CAMUS, J.-P., EMERIT, I., GUILLIEN, R. P., CROUZET, J., and FOUROT, J. Retinopathy in Polymyositis (Retinopathie bei poly- (1970) Ann. Med. intern., 121, 149 mYOSitiS) OTRADOVEC, J., STIBOR, V., and SUTA, M. (1970) Klin. Mbt. Augenheilk., 156, 498 7 figs, 12 refs Radiographic Features of Sj6gren's Syndrome SILBIGER, (See Opthal. Lit., vol. 24) M. L. (1970) Geriatrics, 25, 114 4 figs, 10 refs 578 Annals of the Rheumatic Diseases Ann Rheum Dis: first published as 10.1136/ard.29.5.569 on 1 September 1970. Downloaded from

Relationships between Progressive Scleroderma and Clinical Picture of Systemic Lupus Erythematosus in the liant Tumours (Uber die Beziehungen zwischen Last Two Decades [In Czech] VACHTENHEIM, J. (1970) progressiver Sklerodermie und malignen Tumoren) Vnitfni Lek., 16, 105 1 fig., 11 refs HOLZMANN, H., and FRISCH, W. (1970) Arztl. Forsch., 24, 129 2 figs, 89 refs Familial Aspects of Systemic Lupus Erythematosus. Report of Three Cases in One Family [In Portuguese] Progressive Heart Block in a Case of Scleroderma BARR, FILHo, A. C. (1969) Rev. Ass. mid. Minas Gerais, 20, 197 I. M., ABRAMov, A., DREYFUSS, F., YAHIN, J. H., and 1 fig., 16 refs NEUFELD, H. N. (1970) IsraelJ. med. Sci., 6, 373 5 figs, 14 refs Errors in the Diagnosis of Systemic Lupus Erythematosus Treatment of Scleroderma by Rheomacrodex ALANI, (Irrtumer bei der Diagnose des systematisierten Lupus M. D. (1970) Acta derm.-venereol. (Stockh.), 50, 137 erythematosus) CRuz-FILHo, A., and SCHULER, B. 20 refs (1970) Z. Rheumaforsch., 29, 102 23 refs Clinical Picture of Articular Chagnes in Progressive Systemic Lupus Erythematosus BRANDSMA et al. (1970) Systemic Sclerosis in Children [In Polish] SZYMA14SKA- Angiology, 21, 172 JAGIELLO, W., and RoNDIo, H. (1970) Rheumatologia (Warsz.), 8, 1 4 figs, 37 refs Type 1 Dysgammagiobulinemia, Systemic Lupus Ery- thematosus, and Lymphoma SMTnH et al. (1970) Amer. Systemic Sclerosis associated with Auto-Immune Haemo- J. Med., 48, 113 lytic Anaemia CHAvEs et al. (1970) Brit. J. Derm., 82, 298 Systemic Lupus Erythematosus. Transmission of Clinical Manifestations and Biological Factors from the Mother Radiological Appearance of Osteoarticular Changes in to the Newborn Infant (Lupus eryth6mateux systemnique. Progressive Systemic Sclerosis in Children [In Polish] Transmission de manifestations cliniques et de facteurs JAKUBOWSKA, K., RoNDio, H., and SZYMAN'SKA-JAGIELLO, biologiques de la mere au nouveau-n6) CRUVEILLER, J., W. (1970) Reumatologia (Warsz.), 8, 11 4 figs, 29 refs HARPEY, J.-P., VERON, P., CANNAT, A., DELATTRE, A., HERVET, E., LAFOURCADE, J., and TuRPIN, R. (1970) by copyright. Scleroderma as a Systemic Disease in Dermatological Arch. franc. Pjdiat., 27, 195 3 figs, 45 refs Practice ZIPRKOWSKI, L., and FIENSTEIN, A. (1970) Harefuah, 78, 344 (English summary, p. 366) 16 figs, Clinical Observations on Systemic Lupus Erythematosus 1 5 refs (Considerazioni cliniche sul lupus eritematodes sistemico) MACCHIONI, P., JUDICA-CORDIGLIA, A., and PANATARO, Measurement of Creatine Phosphokinase in Patients with C. (1970) Minerva med., 61, 908 2 figs, 14 refs Scleroderma and Dermatomyositis (Die Bestimmung der Kreatin-Phosphokinase bei Sklerodermie und Derma- Occurrence of Systemic Lupus Erythematosus in Associa- tomyositis-Kranken) DEBRECZENI, M., and LADANYI, tion with Ethosuccimide DABBOUS and IDRISS JP. (1970) Hautarzt, 21, 81 7 refs Therapy (1970) J. Pediat., 76, 617 http://ard.bmj.com/ Clinical Features and Prognosis of Renal Manifestations of Lupus Erythematosus (Zur Klinik und Prognose der Comparison of the Microangiopathy of Systemic Lupus Nierenmanifestationen bei Lupus erythematodes) Erythematosus, Dermatomyositis, Scleroderma, and Dia- HARTL, W., Roos, R., and GENTH, E. (1970) Klin. betes Mellitus NORTON, W. L. (1970) Lab. Invest., 22, Wschr., 48, 711 11 figs, 56 refs 301 14 figs, 20 refs Polymorphous Light Eruption and Lupus Erythematosus SLE-Like Deposition of Immunoglobulins in the Skin in Fisher et al. (1970) Arch. Derm., 101, 458 Rosacea SALO, P. 0. (1970) Ann. clin. Res., 2, 28 1 on September 28, 2021 by guest. Protected fig., 9 refs Nature of Discoid Lupus Erythematosus HAIM, S., and SHAFRmR, A. (1970) Acta derm.-venereol. (Stockh.), 50, 7S and 19S Isoagglutiins in Systemic Lupus Erythema- 86 2 figs, 16 refs tosus BAUM, J. (1970) Acta rheum. scand., 16, 1 1 fig., 10refs Liver in Disseminated Lupus Erythematosus; Hepatitis and Cirrhosis with Autoantibodies (Foie du lupus ery- Wegener's Granulomatosis [In Russian] EREMENKO, th6mateux dissemin6; h6patites et cirrhoses avec auto- N. S. (1969) Oftal. Zh., 24, No. 5, p. 386 anticorps) FRAssE, H., BEETscHEN, A., DUVERNE, J., BARIL, A., BRlmzni, C.-P., and tTAIX, J.-P. (1970) J. Clinicopathologic Conference: Wegener's Granulomatosis MMd. Lyon, 51, 1067 1 fig., bible. WASHINGTON UNIvERsrrY SCHOOL OF MEDICINE (1970) Amer. J. Med., 48, 496 Disseminated Lupus Erythematosus as the Rheumatol- gist sees it Today (Le visage actuel pour le rhumato- Pseudotumor of the Orbit and Limited Wegener's Granu- logue du lupus erythemateux dissemin6) KAHN, M. F., lomatosis CASSAN et al. (1970) Ann. intern. Med., 72, and SZE, M. DE (1970) Rhumatologie, 22, 65 12 refs 687 Abstracts 579 Ann Rheum Dis: first published as 10.1136/ard.29.5.569 on 1 September 1970. Downloaded from

Immunology and serology Elevated IgG Antiglobulins in Patients with Seronegative- Rheumatoid Arthritis TORRIGIANI, G., RoIrr, I. M., Immune Complexes in Rheumatoid Synovitis: A Mixed LLOYD, K. N., and CORBETT, M. (1970) Lancet, 1, 14 Staining Immunofluorescence Study BONOMO, L., TuRsi, 4 figs, 12 refs A., TRIzio, D., GILLARDi, U., and DAMMAcco, F. (1970) The authors, working in the departments of immunology Immunology, 18, 557 and rheumatology at the Middlesex Hospital, London, have previously reported that a large proportion of so- This study describes the demonstration of immune com- called sero-negative rheumatoid arthritics possess rheu- plexes in rheumatoid synovial tissue. It deals with the matoid factors of the IgG class. These were detected by detection, by immunofluorescence microscopy, of in adsorption upon insoluble cross-linked rabbit gamma vivo formed deposits containing IgG and rheumatoid globulin (Cohn fraction II), elution at low pH, and factor (RF), and IgG and complement component (,iLc). quantitative estimation by radial diffusion on Mancini The presence of such complexes, involving complement type plates. RF, and antibody globulin has been suspected from other The present study compares the results obtained when observations, including that of low levels of complement insoluble cross-linked horse y-globulin was used in in rheumatoid synovial fluid, but it has hitherto not been place of the rabbit globulin. With very few exceptions demonstrated. higher values were obtained with the horse globulin The authors, working at the University ofBari Medical adsorbent. By the use of this method many more of the School in Italy, examined synovial tissue from seven seronegative rheumatoid arthritics gave results well out- sero-positive and three sero-negative rheumatoid patients, side the range found in normal and osteoarthritis subjects. and from two controls. Immunoelectrophoretically pure, The result also suggest a positive correlation between the specific antisera of human and rabbit origin, conjugated amount of IgG antiglobulin and the activity and extent with contrasting fluorescent dyes were used to visualize of the L. E. GLYNN the components of the immune deposits by mixed direct disease. staining of tissue section. Sections of synovial tissue from the seven sero- Rheumatoid Anti-Gm Factors with Specificity for the positive patients contained IgG-RF complex, and all pFc' Subfragment ofHuman Immunoglobulin G NATVIG, ten patients had IgG-filc synovial deposits. No specific J. B., and TuRNER, M. W. (1970) Nature (Lond.), 225, fluorescence was seen in control sections. The distribution 855 by copyright. was similar in all patients and with both types of deposit Studies on the sites of the determinants on the IgG in the interstitial connective tissue, in vessel walls and molecules reactive with rheumatoid factors have localized perivascular areas, and in the cytoplasm of tissue phago- these to the Fc portion of the heavy chains. Several of cytes. However, the patterns differed in that IgG-31Lc these determinants are allotypic, i.e. they are present in formed smaller and more numerous connective tissue some individuals but not in others and their presence foci than IgG-RF, and the latter was present to a greater is genetically controlled. Amongst these determinants extent in vessel walls, while TgG-/3lc stained mainly are those of the Gm system but, although their existence perivascular tissue. was first discovered by the use of rheumatoid sera, some These findings are discussed in the light of hypotheses doubt has been thrown upon the specificity of these sera concerning pathogenicity and the role of RF in rheuma- and in consequence studies of the Gm groups are now http://ard.bmj.com/ toid arthritis. K. RHODES usually made using nonrheumatoid anti-Gm reagents chiefly derived from individuals who have received mul- transfusions. Serum Immunogobulin and PlC/IP1A Globulin Levels in tiple Rheumatoid Arthritis WASASTJERNA, C., and EKELUND, P. The present study from the Rikshospitalet University (1969) Acta med. scand., 185, 469 2 figs, 26 refs Hospital, Oslo, and the Institute of Child Health, London, shows that the anti-Gm activity of rheumatoid Serum total Ig, IgG, IgA, IgM, and 41A globulin (which sera can indeed be specific, although some four to eight

is closely correlated with total complement activity) timesless sensitive than correspondingnon-rheumatoid re- on September 28, 2021 by guest. Protected were estimated by a radial immunodiffusion method in agents. The specificity of these rheumatoid anti-Gm 55 patients with rheumatoid arthritis and 48 'controls' reagents was especially well shown when a fragment of (blood donors), both groups being divided into approxi- the Fc portion referred to as pFc' and carrying the Gm mately equal groups aged < 55 years or > 55 years. (Xc) grouping was used to inhibit the agglutination system The mean Ig, IgG, IgA, and IgM were higher in the employed. This pFc' fragment is a dimeric subunit of patients than in the controls, though when age was taken 26,000 mol.wt. derived from the C terminal end of the into consideration the difference with respect to IgA and heavy chains. The other Gm groups studied (x, g, and b) IgM was not significant. The increase in IgG and Ig apparently have their determinate sites further towards levels was greater in patients with a relatively high ESR the free amino end of the heavy chains. L. E. GLYNN and low haemoglobin levels. No significant difference in 41A values were found between patients and controls. Altered Reactivity in Mixed Lymphocyte Culture of In controls, total Ig and IgG rose with age whereas Lymphocytes from Patients with Rheumatoid Arthritis IgM fell. In the patients there was no relation with age. ASTORGA, G. P., and WnILAM, R. C., JR. (1969) Arthr. In patients but not in normals IgA levels were higher in and Rheum., 12, 547 3 figs, 17 refs males than females. 161A was positively correlated with total Ig and with IgG in patients but not in controls. A series of 22 patients with classical rheumatoid arthritis, J. BALL six of whom were on small doses of corticosteroid, and

J 580 Annals of the Rheumatic Diseases Ann Rheum Dis: first published as 10.1136/ard.29.5.569 on 1 September 1970. Downloaded from

controls from among healthy blood-bank volunteers, Removal of Aggregated and Nonaggregated Autologous were investigated using a one-way stimulation mixed Gamma Globulin from Rheumatoid Joints SLIwINSKI, lymphocyte culture (MLC). In fourteen of 22 experiments A. J., and ZVAIFLER, N. J., (1969) Arthr. and Rheum., 12, the rheumatoid arthritis lymphocytes showed no mutual 504 5 figs, 17 refs stimulation, but in another eight cultures pairs the cells showed positive responses as much as six times above The authors, at Georgetown University Hospital, ex- base-line values. When mitomycin-treated lymphocytes amined the effects of IgG injection into knee joints in from normal subjects were cultured with lymphocytes the presence and absence of rheumatoid factor. Reduced from patients with rheumatoid arthritis, the normal cells and alkylated IgG is a particularly suitable material, produced marked cell stimulation in sixteen of the 22 since it does not cause inflammation by itself. pairs tested; there was no stimulation in the remaining Eleven patients with rheumatoid arthritis were studied, six pairs. When control normal lymphocytes were cul- and two with degenerative joint disease. Autologous IgG tured with stimulating rheumatoid arthritis lymphocytes, was produced from serum by DEA cellulose chromato- marked blast transformation occurred in nineteen of the graphy. This was treated with 2-mercapto-ethanol. 22 experiments. The difference in response among various Radio-labelling was with 1311 or 1251. Heat-aggregation pairs of rheumatoid arthritis lymphocytes was con- was at 630C. for 15 to 30 minutes. Albumin was heated sistent when re-studied on two or three occasions. If more strongly. An external counter was used for body- there was apparent lack of MLC cell response, the capa- counting. city for lymphocyte stimulation was verified by positive It was found that the rate of protein removal, though phytohaemagglutinin response. variable from patient to patient, was faster the greater The lack of cross-stimulation could not be correlated the inflammation of the joint. Although albumin is at with the presence or absence of serum anti-gammaglobu- first removed faster, the rate after the first 2 days is lin factors nor with the use of anti-inflammatory drugs. similar to that of IgG or reduced IgG, which are removed The apparent lack of mutual lymphocyte response ob- at similar rates. However, heat aggregation of reduced served among the rheumatoid pairs studied may be autologous IgG enhanced the rate of removal from the related to critical ratios of mixed cells. No explanation joint, in both rheumatoid and osteoarthritic patients. could be given for these results; it was suggested that Heat-aggregated albumin was also removed more heterogeneity within the lymphoid system may be altered quickly. An inflammatory joint reaction was noted in

in patients with rheumatoid arthritis, so that the cells only one of the 24 injections in all thirteen patients. by copyright. capable of responding to histoincompatibility antigens During the reaction there was delayed removal of IgG is in some way altered. B. M. ANSELL and reduced IgG. G. LOEWI

Cardioglobulin: Tissue Localization and Plasma Activity with Special Reference to Cardiovascular Disease and Lupus Erythematosus LEONARD, E. J., MAXIMIN, T. J., Agmmamglobulinaemia with Polyarthritis and Subcutane- and HAJDU, S. (1968) Circulat. Res., 22, 527 4 figs, 8 refs ous Nodules BARNETr, E. V., WINKELSTEIN, A., and WEINBERGER, H. J. (1970) Amer. J. Med., 48, 40 7 figs, Mammalian plasma contains a group of proteins, cardio- 34 refs

globulins, which together mediate increased contractility http://ard.bmj.com/ of isolated frog heart, according to previous reports of This paper from the Department of Medicine, University these authors. Plasma cardioglobulin A is increased in College of Los Angeles, describes a study of a 4-year-old patients with hypertension and aortic stenosis, and plasma boy with polyarthritis, no detectable serum immuno- cardioglobulin C is decreased in some patients with con- globulin, a normal delayed hypersensitivity response, and gestive heart failure. The present report deals with the subcutaneous nodules resembling rheumatoid nodules localization of cardioglobulin C in tissues. Frog hearts histologically but in atypical sites. pretreated with human cardioglobulin B and rat cardio- The patient's parents were healthy, but their cultured globulin C were purified with guinea-pig antiserum blood lymphocytes showed defective uptake of thymidine against rat cardioglobulin C. This inhibited the effect of and only half the expected number of immunoglobulin- on September 28, 2021 by guest. Protected subsequently purified cardioglobulin A. Fluorescent producing cells. The patient's lymphocytes transformed staining (by a method inadequately described) showed in the presence of phytohaemagglutinin but did not binding of anticardioglobulin C antibody on the frog produce immunoglobulins. heart muscle. On sections, the same antiserum showed Cells containing immunoglobulins were found in the binding with various rat tissues, including intercellular synovium in which complement was also detected. material in muscle and apparently basement membrane Synovial fluid complement was depressed; its immuno- in kidney. Further investigations of cardioglobulin globulin content was 2- 5 mg. per cent. for IgG (compared levels in human plasma showed especially low levels in with less than 0-019 mg. per cent. in the serum); it con- 24 cases of systemic lupus erythematosus, but normal tained no ragocytes; rheumatoid factor was detected levels in seventeen cases of rheumatoid arthritis or other only at a titre of 1: 2. The authors conclude that locally- connective tissue disease. The authors suggest that plasma produced complement-fixing antibodies may be respon- concentrations of cardioglobulin may vary inversely with sible for the arthritis but that ragocytes cannot be impli- tissue activity, and that the low plasma concentrations cated. in systemic lupus erythematosus may indicate the func- The patient's nodules, which disappeared after treat- tional significance of cardioglobulins in the tissues. ment with gammaglobulin, contained neither immuno- E. J. HOLBOROW globulins nor complement. J. BALL Abstracts 581 Ann Rheum Dis: first published as 10.1136/ard.29.5.569 on 1 September 1970. Downloaded from

Lymphocyte Transformation in Patients with Amyloidosis Rheumatoid Arthritis and the Determination of Various LEHNER, T., CAMERON, J. S., and WARD, R. G. (1970) Antistreptococcal Antibodies (Artrite reumatoide e la Clin. exp. Immunol., 6, 439 20 refs determinazione di alcuni anticorpi antistreptococcici) RoMITO, S., and FALCHI, A. (1969) Fracastoro, 62, 626 This paper, from Guy's Hospital Medical School, in- 20 refs vestigates whether there is any impairment of cellular immunity, as judged by the lymphocyte transformation Applicability of an Increased Antistreptolysin Titre in test, in patients with amyloidosis. Seven patients with Differential Diagnosis (Zur differentialdiagnostischen biopsy-verified renal amyloidosis were investigated, Verwertbarkeit erhohter Antistreptolysintiter) KLEIN, together with nine controls. The test was carried out G., and KLEIN, W. (1970) Wien. Z. inn. Med., 51, 160 according to a method previously described, using phyto- 1 5 refs haemagglutinin (PHA), purified protein derivative (PPD), extract of Candida albicans, herpes simplex virus, and a Occurrence of Two IgG, Earlier Unknown, in Joint Fluid homogenate of foetal liver as antigens. In addition, amy- and Serum from Rheumatoid Arthritis SVARTZ, N. (1970) loid fibrils, prepared by differential centrifugation from Acta med. scand., 187, 303 2 figs the liver of a patient with primary amyloidosis, were used. Only the test involving stimulation with herpes Value of the Loose-body Test and of Fluorescence Tech- simplex virus revealed any impairment of cell-mediated niques in Rheumatism (Aussagewert des loose-body- immunity in the amyloid group. Stimulation by the Tests und des Fluoreszenzverfahren bei Rheumarkanken) amyloid fibrils caused lymphocyte transformation in ZABEL, H. (1969) Z. Rheumajorsch., 28, 454 12 refs five out of seven patients with amyloid, but also in three out of eight healthy controls. The reaction is thus in- Immunologic Study of the Blood Serum and of the Synovial sufficiently specific to be used as a diagnostic test for Fluid in Patients with Rheumatoid Arthritis STROESCU, amyloidosis. J. R. DALY O., GHEORGHIU, M., and GHELERTER, L. (1970) Rev. roum. MMd. interne, 7, 31 2 figs, 12 refs Rheumatoid Rosette Phenomenon. I. New Technique for Hypercatabolism of Normal IgG; an Unexplained Im- Detection of the Rheumatoid Factor at Cell Level. (Le munoglobulin Abnormality in the Connective Tissue phenomene de la rosette rhumatoide. I. Nouvelle Diseases WOCHNER, R. D. (1970) J. clin. Invest., 49, by copyright. methode de detection du facteur rhumatoide au niveau 454 6 figs, 39 refs cellulaire) BACH, J.-F., DELRIEU, F., and DELBARRE, F. (1970) Presse med., 78, 301 17 refs Impaired Lymphocyte Stimulation by Some Streptococcal (See Abstr. WId Med. (1970), 44, 577) Antigens in Patients with Recurrent Aphthous Stomatitis and Rheumatic Heart Disease FRANCIS, T. C., and OPPENHEIM, J. J. (1970) Clin. exp. Immunol., 6, 573 2 Complement in Rheumatoid Inflammation. [Review Article figs, 30 refs in English] NATVIG, J. B., and WINCHESTER, R. J. (1969) Acta rheum. scand., 15, 161 Bibl. In vitro Studies on the Pathogenesis of Rheumatoid Arthritis by Means of the Lymphocyte Transformation

Test (In vitro-Studie zur Pathogenese der primer chronis- http://ard.bmj.com/ Altered Immunoglobulin Metabolism in Systemic Lupus chen Polyarthritis mittels des Lymphocytentransforma- Erythematosus and Rheumatoid Arthritis LEVY, J., tionstests) ROTHENBERGER, W., and THIELE, H. G. BARNETT, E. V., MACDONALD, N. S., and KLINENBERG, (1970) Klin. Wschr., 48, 518 45 refs J. R. (1970) J. clin. Invest., 49, 708 Lysosomes in Lymphocytes of Peripheral Blood in Certain Importance of the Latex Test in Uveitis [In Polishj Connective Tissue Diseases [In Polish] CHWALIINSKA- SADOWSKA, H. (1969) Reumatologia (Wars-.), 7, 305 6 HORODEN4SKI, J. (1969) Klin. oczna, 39, 855 10 refs figs, 45 refs (See Ophthal. Lit., vol. 23) on September 28, 2021 by guest. Protected Study of Lymphocytic Synthesis of Gammaglobulins in Genetic Studies on the Gc Protein Group System in Systemic Lupus Erythematosus (Studio della sintesi Rheumatoid Arthritis in Adults: Distribution of the delle gammaglobuline da parte dei linfociti in corso di Characteristics of the Gc System and their Heredity in eritematoviscerite luposa) FONTANA, L., and AiUTI, F. Three Generations [In Polish] BANIOWSKI, A. (1970) (1970) Progr. med. (Roma), 26, 33 2 figs, 15 refs Acta med. pol., 11, 59 19 refs Rheumatoid Factor as a Functional Protein or an Anomaly of Protein Structure (Gedanken zum Rheumafaktor- BetalA-(C13)-Globulin Concentration in the Serum in Funktionsprotein oder Proteinstrukturanomalie) KOHN, Acute and Chronic Renal Disease, Liver Disease, and R. A. (1970) Z. Rheumaforsch., 29, 14 2 figs, 14 refs Rheumatic Diseases (Die Beta-1A-Globulin-(C'3-) Konzentration im Serum bei akuten und chronischen Chromatography of Rheumatoid Arthritis Serum on Nephropathien, Hepatopathien und rheumatischen Er- Sephadex G 200 (Die Chromatographie von Rheumatoid- krankungen) POGGLITSCH, H., GIESSAUF, W., FELDNER, Arthritis-Seren an Sephadex G 200) GERLACH, D., H., and STOCKL, G. (1970) Wien. med. Wschr., 120, KNOLL, H., and OTro, R. (1970) Z. Immun.-Forsch., 139, 381 4 figs, 17 refs 172 2 figs, 16 refs 582 Annals ofthe Rheumatic Diseases Ann Rheum Dis: first published as 10.1136/ard.29.5.569 on 1 September 1970. Downloaded from

Problems of Standardization of Tests for Rheumatoid Immunofluorescent Appearance of Antinuclear Antibodies Factor (Probleme der Standardisierung der Nachweis- and LE Cells in Connective Tissue Diseases [In Polish] reaktionen des Rheumafaktors) Orro, R., KNOLL, H., KoLARzowsrA, B. (1970) Pol. Tyg. lek., 25, 9 2 figs, and TANNER, E. (1970) Z. Rheumaforsch., 29, 1 5 figs, 17 refs 81 refs Comparative Evaluation ofAntistreptolysin and Antistrep- Comparative Studies of the Sensitivity, Value, and Depend- todornase Titres. L Acute Rheumatism. H. Acute Glomern- ability of Serological Tests in Rheumatic Diseases (Ver- loneporitis (Valutazioni comparative tra titolo ASO e A- gleichende Untersuchungen zur Empfindlichkeit, Wertig- DNAsico. I. Malattia reumatica acuta. II. Glomerulone- keit und Zuverlassigkeit serologischer Rheurnatests) frite acuta) Romrro, S. (1969) Fracastoro, 62, 614, 620 ScHMIDT, K., MUELLER-ECKHARDT, CH., and BECKMANN, 8 figs, 13 refs D. (1970) Z. Rheumaforsch., 29, 20 17 refs Importance of Anti-M Antibody Titration in the Sero- International Reference Preparation of Rheumatoid logical Diagnosis of Rheumatic Fever and Streptococcal Arthritis Serum ANDERSON, S. G., BENTZON, M. W., Infections (Rilievi sull'importanza della ricerca degli HOUBA, V., and KRAG, P. (1970) Bull. Wid HIth Org., anticorpi anti-M nella diagnostic sierologica della malat- 42, 311 1 fig., 6 refs tia reumatica e'delle infezioni streptococciche) FANINI, A., VIGNOLA, D., STRAPPARAVA, E., and ZANINI, S. (1969) Quad. Sclavo Diagn., 5, 419 1 fig., 14 refs Serum Antinuclear Antibodies in Rheumatoid Arthritis HUGHES, G. D., and RarHFIELD, N. F. (1970) Conn. Waldenstrom's Macroglobulinaemia with Anti-IgG Med., 34, 171 2 figs, 23 refs Activity: A Series of Five Cases BONOMO et al. (1970) Clin. exp. Immunol., 6, 531 In vivo and in vitro Anti-Nuclear Reactions in Lupus Patients ZWETMAN, B., and HELDRETH, E. A. (1968) Studies on the Possible Presence of the Urate-Binding Arthr. and Rheum., 11, 660 Alpha-1-Alpha 2 Globulin in Human Erythrocytes ALv-

SAKER, J. 0. (1970) Acta rheum. scand., 16, 144 1 fig., by copyright. Proposed Classification of Primary Immunologic De- 14 refs ficiencies SELIGMANN, M., FUDENBERG, H. H., and GOOD, R. A. (1968) Amer. J. Med., 45, 817 Reactions of G-Myeloma Sera with Rheumatoid Arthritis Sera KASUKAWA, R., YOSHIDA, H., YOSHIDA, T., and Gm Distribution in Rheumatic Diseases with Special MILGROM, F. (1970) Int. Arch. Allergy., 38, 590 3 figs, Reference to Rheumatoid Arthritis. Part I. Gm (a) and 12 refs Gm (x) Factors in Rheumatic Diseases (Gm-Eigenschaften bei rheumatischen Erkrankungen unter BerUcksichtigung der Polyarthritis chronica progressive. I. Mitteliung: in Gm (a)- und Gm (x)- Faktoren bei rheumatischen Experimental studies animals http://ard.bmj.com/ Erkrankungen) NEUMANN, W., BARTHEL, E., TANNER, and K. Z. ges. inn. Med., 25, 308 Chronic Arthritis produced by Streptococcal L-Forms [in E., SEIDEL, (1970) Rabbits] COOK, J., FINCHAM, W. J., and LACK, C. H. (1969) J. Path., 99, 283 11 figs, 16 refs Range and Specificity of Antinuclear Antibodies in Sys- temic Lupus Erythematosus ALARC6N-SEGOVIA, D., This investigation, from the Department of Pathology, FisHBEIN, E., ALCALk, H., OLGUWN-PALACIOS, E., and Institute of Orthopaedics, Royal National Orthopaedic ESRADA-PARRA, S. (1970) Clin. exp. Immunol., 6, 557 Hospital, Stanmore, Middlesex, describes the arthritic 6 figs, 28 refs response of rabbits to the intra-articular injection of the on September 28, 2021 by guest. Protected L-form of the C 203 S strain of group A streptococci used previously for the production of streptolysin S. In vitro Assay of Cell-Mediated Immunity: The Inhibition and of the L-form of the non-haemolytic variant C 203 U. of Migration of Sensitized Human Lymphocytes by HI-A The reactions to these L-forms were compared with those Antigens FALK et al. (1970) Clin. exp. Immunol., 6, 445 caused by the intra-articular injection of the parent organism C 203 S and by the injection of protoplast New Slide Test for Reatoid Factor Determination membranes obtained from C 203 S streptococci. (Neuer agglutinationstest zur Bestimmung des A chronic nonarticular arthritis was produced by Rheumafaktors auf dem Objekttrager) FRoHLIaH, E. injecting the L-forms. Heating at 80'C. for 20 min., a Wien. med. Wschr., 120, 153 10 refs temperature which inactivates the haemolytic lysosome- (1970) labilizing fraction of streptolysin S, did not impair the response to the organisms, a procedure which, however, Importance of Antibody Concentration, Binding Constant, caused organismal death. The histological changes pro- and Heterogeneity in the Suppression of Immunity to the duced resembled those of rheumatoid arthritis. Only Rh Factor POLLACK, W., and KOCESKY, R. J. (1970) two of 32 animals given C 203 S L-form developed pre- Int. Arch. Allergy., 38, 320 4 figs, 16 refs cipitating antibodies against a suspension of the organ- Abstracts 583 Ann Rheum Dis: first published as 10.1136/ard.29.5.569 on 1 September 1970. Downloaded from ism; weak reactions against horse serum (present in the Effect and Storage of Gold in Experimental Formalin medium in which the L-forms were first cultured) were Arthritis of the Rat (Wirkung und Speicherung von Gold occasionally detected, but there was no association be- bei der experimentellen Formalinarthritis der Ratte) tween antihorse serum antibody formation and the SCHEIFFARTH, F., BAENKLER, H. W., and SCaHRG, G. development of arthritis. No evidence of rheumatoid (1970) Z. Rheumaforsch., 29, 42 12 refs factor formation was detected in rabbits which developed arthritis. The experiments show that an arthritis similar to that Depletion of Long-lived Lymphocytes in Old New Zealand produced previously by the injection of streptolysin S Black Mice DENMAN and DENMAN (1970) Clin. exp. can be caused by the injection of the killed L-form of the Immunol., 6, 457 group A streptococcus used to produce the streptolysin S. The nonhaemolytic mutant organism the L-form of Adjuvant-induced Arthritis: An Immunologic Model of which does not contain streptolysin S, was equally effec- Articular and Connective Tissue Disease PEARSON et al. tive in causing arthritis. (1969) Trans. Ass. Amer. Phycns., 82, 253 The possibility is suggested, without evidence, that the L-forms which cause arthritis transform lymphocytes, releasing cytotoxic factors injuring joint tissue. A second Effects of Osmium Tetroxide on the Rabbit Knee Joint unsubstantiated possibility to which attention is drawn Normal Synovial Membrane MOTroNEN, M., PANTIO, is the presence in the L-form surface of an antigen cross- M., and NEVALAINEN, T. (1970) Acta rheum. scand., 16, reacting with a synovial antigen. D. L. GARDNER 121 7 figs, 21 refs

Congenital Transmission in Mice of an Active Agent from Human Rheumatoid Arthritis WARREN, S. L., MARMOR, L., LIEBES, D. M., and HOLLINS, R. L. (1969) Nature Biochemical studies (Lond.), 223, 646 Cell-free extracts of normal and of rheumatoid synovial Arthritogenic Effect of Indole, Skatole, and Other Trypto- tissue were phan Metabolites in Rabbits NAKONECZNA, I., FORBES, by copyright. injected intraperitoneally into newborn mice. J. C., and ROGERS, K. S. (1969) Amer. J. Path., 57, 523 The site and time of injection was found to be unimport- 1 17 refs ant. No abnormalities were discovered in the control fig., animals or their litters. In some of the animals injected In view of the reports on abnormal tryptophan with extract from rheumatoid cells changes were noted metabo- which lism in RA, it was considered worthwhile to examine bore gross and histological similarities to rheuma- metabolites of this pathway for their ability to induce toid arthritis. Vertical congenital transmission to the lesions in fourth or fifth generation was noted. The results indicate rabbit joints. Indole and skatole produced a the presence of an active in human synovitis consisting of early polymorph infiltration transmissible agent followed by synovial cell hyperplasia and a mono- rheumatoid arthritis tissue. W. C. DICK nuclear cell infiltrate. Subsynovial fat was infiltrated and replaced by granulation tissue. Multiple prolonged http://ard.bmj.com/ injections produced chronic disease with pannus and Inhibition of Adjuvant Disease in Rats by the Interferon- cartilage destruction. inducing Agent Pyran Copolymer KAPUSTA, M. A., and In MENDELSON, J. (1969) Arthr. and Rheum., 12,463 3 figs, contrast, the other metabolites, tryptophan, kynu- 34 refs renine, 3-hydroxykynurenine, kynurenic acid, anthranilic (See Abstr. WId Med. acid, zanthurenic acid, 3-hydroxyanthranilic acid, nico- (1970), 44, 409) tinic acid, nicotinamide, oxindole, isatin, and indican into rabbit knee joints did not produce any pathological

changes. on September 28, 2021 by guest. Protected Arthritis induced with Freund's Adjuvant and Its Relation- An ship to Changes in the Stomach, Small Intestine, and explanation involving the lipophilic activity of the Thymus JULKUNEN, H., and ROKKANEN, P. (1970) Acta arthritogenic compounds is offered, postulating inter- rheum. scand., 16, 22 4 12 refs action of such compounds with cell and organelle mem- figs, branes, leading to lysosomal release. G. LOEWI

Influence of Gold on the Survival Time of Skin Homo- Comparative Studies on the Activity of LDH, MDH, and grafts in Mice (Die Beeinflussung der Uberlebenszeit von CAP in the Synovial Exudates and in the Serum as Supple- Hauthomotransplantaten der Maus durch Gold) SCHEI- mentary Diagnostic Criteria of Rheumatoid Arthritis [In FFARTH, F., BAENKLER, H. W., and ISLINGER, M. (1970) Polish] BANIOWSKI, A., CICHECKA, K., DROZDZ, H., Z. ges. exp. Med., 152, 125 10 refs J5DRYCHOWSKI, A., and ZIELONKA, E. (1969) Reumato- logia (Warsz.), 7, 319 21 refs Adjuvant Arthritis in the Rat. m. Investigations on Pathogenesis (Die Adjuvansarthritis der Ratte. III. Toxicity of Streptolysin 0 for Beating Mammalian Heart Untersuchungen zur Pathogenese) KErrEL, W., and Cells in Tissue Culture THOMPSON, A., HALBERT, S. P., ZEIGELER, J. (1979) Z. Rheumaforscb., 28, 434 4 figs, and SMrrT, U. (1970) J. exp. Med., 131, 745 10 figs, 30 11 refs refs 584 Annals of the Rheumatic Diseases Ann Rheum Dis: first published as 10.1136/ard.29.5.569 on 1 September 1970. Downloaded from

Demonstration of the Therapeutic Effect of Antirheumatic and cessation in the other of the immunosuppressive Drugs in Rheumatoid Arthritis by Measurement of Hydro- therapy. The final patient had already partly remitted xyproline Excretion in the Urine (Objektivierung der with corticosteroid therapy but was changed to azathio- Behandlungserfolge mit Antirheumatika bei der primar- prine when cataracts developed. She went on to achieve a chronischen Polyarthritis durch die Hydroxyprolin- full remission. messung im Urin) HARTMANN, F., ROHDE, J., and The authors consider that failure to respond to azathio- SCHMIDT, A. (1969) Z. Rheumaforsch., 28, 447 2 figs, prine usually indicates chronic renal disease with fibrosis. 21 refs On the other hand, evidence of active disease, as shown by inflammatory glomerular lesions and a low serum Therapeutic Action of Antirheumatic Drugs through their complement level, and maintenance of normal renal Influence on Collagen Metabolism (Beeinflussung des function do not always imply a good therapeutic result. Kollagenstoffwechsels durch Antirheumatika als thera- Leucopenia occurred in all the patients who responded peutisches Prinzip) FEGELER, K., and GERLACH, U. to immunosuppressive therapy, but there was no appre- (1970) Z. Rheumaforsch., 29, 107 7 figs, 49 refs ciable fall in the white blood count in non-responders, indicating that improvement is most likely to occur with Structural and Morphological Investigation of Poly doses that approach or reach levels of toxicity. [Gly-Ala-Pro] SCHWARTZ, A., ANDRIES, J. C., and D. A. PITKEATHLY WALTON, A. G. (1970) Nature (Lond.), 226, 161 2 figs, 5 refs Corticosteroid Crystals in Synovial Fluid KAHN, C. B., Biochemical and Metabolic Abnormalities in Articular HOLLANDER, J. L., and SCHUMACHER, H. R. (1970) J. Cartilage from Osteoarthritic Human Hips MANKIN, Amer. med. Ass., 211, 807 5 figs, 14 refs H. J., and LIPPIELLO, L. (1970) J. Bone Jt Surg., 52-A, Locally-acting corticosteroids, previously injected into a 424 3 figs, 45 refs joint, are a potential source of error in the interpretation of crystals discovered in synovial fluid. The authors, at Pathology of the Alpha Chains in a Eurasian (Nouveau the University of Pennsylvania, incubated five commonly- cas de maladie des chaines alpha chez un Eurasien) used suspensions of corticosteroids with synovial fluid. RAMBAUD et al. (1970) Ann. Med. intern., 121, 135 This did not alter the morphology of the crystals. Methyl by copyright. prednisolone acetate and triamcinolone acetonide esters Clearance of 1251-Liabelled Urographin from Knee Joints had no definable longitudinal axis under polarized light. in Rheumatoid Arthritis STENSTROM, R., and WEGELIUS, Birefringence could not be determined and their crystals 0. (1970) Acta rheum. scand., 16, 151 5 figs, 9 refs least resembled those of sodium urate or calcium pyro- phosphate. Prednisolone terbutate crystals retained a Plasma Cortisol Assay LURIE (1970) J. Amer. med. Ass., longitudinal axis and a positive birefringence somewhat 1851 like calcium pyrophosphate. Triamcinolone hexacetonide 211, and betamethasone acetate esters showed strongly nega- tive birefringent rod-shaped crystals which might be in- distinguishable from sodium biurate. Triamcinolone Therapy hexacetonide crystals had been detected in joints injected http://ard.bmj.com/ more than a month previously. The authors urge the Treatment of Lupus Nephritis with Azathioprine MAHER, greatest caution in the interpretation of crystals found in J. F., and SCHREINER, G. E. (1970) Arch. intern. Med., synovial fluids from joints previously injected with sus- 125, 293 3 figs, 16 refs pensions of corticosteroids. A. ST. J. DIXON This report from the Georgetown University School of Medicine describes the use of azathioprine (1 *7 to Response to Treatment of Individual Patients in a Drug 4- 3 mg./kg./day) in eleven patients with nephritis of sys- Trial SUTHERLAND, S. S., PHILIP, A. E., and SUTHER- on September 28, 2021 by guest. Protected temic lupus erythematosus. Renal biopsy was performed LAND, M. S. (1969) Brit. J. Psychiat., 115, 1383 5 refs in six patients before starting therapy. Prednisone had been used in all the patients but had been ineffective in In this paper from the Kingseat Hospital, Newmachar, ten and the eleventh patient had developed steroid Aberdeenshire, the authors re-analysed their own earlier cataracts. Four patients died during or shortly after data from a comparative trial of 'Prodnol' and Imipramine therapy; three of these had renal failure and in two the in the treatment ofdepression. By using statistical methods disease appeared to increase in severity shortly after the for the analysis of trends,* more detailed and clinically azathioprine was commenced. Two other patients showed useful information could be obtained than was revealed no improvement in renal function, but follow-up of 18 by conventional statistical methods. M. J. JEFFREY months and 4 years respectively has shown no progression of the renal lesion. A further two patients showed tem- porary improvement in urinary abnormalities and in Comparative Doubleblind Trial of 16,091 RP and Indo- tests of renal function, but they died approximately 6 methacin in Rheumatoid Arthritis (Essai comparatif en months later, having been lost to follow-up. Acute in- double aveugle du 16 091 RP et de l'indometacine dans fection during azathioprine therapy developed in two les polyarthrites chroniques) VIGNON, G., BOISSEL, J.-P., patients. Both recovered and there followed a gradual and CIBERT, M. (1969) Rev. Rhum., 36, 715 remission in the renal findings despite reduction in one (See Abstr. Wid Med. (1970), 44, 628) Abstracts 585 Ann Rheum Dis: first published as 10.1136/ard.29.5.569 on 1 September 1970. Downloaded from

Results of a Controlled Trial of Methiazinic Acid (16,091 Clinical Trial of a New Combination of a Non-Steroid RP) in Rheumatic Pelvispondylitis, Osteoarthritis of the Anti-inflammatory Drug and a Muscle Relaxant: Butaly- Hip, and Psoriatic Rheumatism (Resultat d'un essai seen (Etude clinique d'une nouvelle association d'un contr6le de l'acide metiazinique (16 091 RP) dans la anti-inflammatoire non-steroidien et d'un decontracturant pelvispondylite rhumatismale, la coxarthrose et le musculaire: le butalyseen) FAMAEY, J. P., and BAUDUIN, rhumatisme psoriasique) StZE, DE, S., KAHN, M.-F., M.-P. (1969) J. beige Rhum. Med. phys., 24, 260 DREYFUS, P., DRYLL, A., SOLNICA, J., and PIERA, J.-B. (1969) Rev. Rhum., 36, 709 1 fig., 4 refs Dimethyl Sulphoxide: Review of the Literature [In Danish] (See Abstr. WId Med. (1970), 44, 627) RASMUSSEN, G., and ANDERSEN, R. B. (1970) Ugeskr. Laeg., 132, 830 17 refs Adrenal Cortical Function in Children on Steroids KUZEMKO, J. A., and LINES, J. G. (1970) Arch. Dis. Childh., 45, 215 28 refs Clinical Experience with a rectally administered Anti- (See Abstr. Wid Med. (1970), 44, 643) rheumatic Antineuritic Preparation (Osservazioni cliniche sull'impiego di un preparato antireumatico antinevritico Cortisone Withdrawal Syndrome in Rheumatoid Arthritis somministrato per via rettale) CESCATI, A., and VEC- and its Management (Das Cortison-Entzugssyndrom bei CHINI. L. (1970) Minerva med., 61, 1350 15 refs progressiv chronischer Polyarthritis und seine Behand- lung) CHLUD, K. (1970) Wien. Z. inn. Med., 51, 59 8 Osmium Penetration into the Organism after Chemical refs Synovectomy of Knee Joints with Osmic Acid [In Polish] (See Abstr. Wid Med. (1970), 44, 550) DUBI&SKA-BIELICKA, A., and LUDWICKI, K. (1970) Reumatologia (Warsz.), 8, 27 4 refs Severe Haemolytic Anaemia in Pregnancy in Nigerians treated with Prednisolone FLEMING, A. F., and ALLAN, N. C. (1969) Brit. med. J., 4, 461 Bibl. Dynamics of Osmium Elimination after Chemical Syno- (See Abstr. Wid Med. (1970), 44, 445) vectomy of Knee Joints with Osmic Acid [In Polish] LUDWICKI, K., and DUBI&SKA-BIELICKA, A. (1970) A Case of Hypersensitivity to Corticosteroids COMAISH, Reumatologia (Warsz.), 8, 31 4 figs, 9 refs

S. (1969) Brit. J. Derm., 81, 919 2 figs, 18 refs by copyright. (See Abstr. Wid Med. (1970), 44, 454) Synoviotherapy by Radioactive Isotopes (Synoviotheses (synoviotherapie par les radioisotopes). Etude de plus de Intra-articular Therapy with a Proteinase Inhibitor (Intra- 400 traitements et perspectives d'avenir) DELBARRE, F., artikulare Therapie mit einem Proteinasenhemmer) et al. (1970) Ann. MMd. intern., 121, 441 THUMB, N., WEIDINGER, P., and ATEFI, K. (1970) Wien. Z. inn. Med., 51, 7 8 refs (See Abstr. WId Med. (1970), 44, 549) Preliminary Observations on the Therapeutic Use of P- Butoxyphenylacethydroxamine [Droxaryl] in Physical Medicine (Premieres considerations sur 1'apport thera- Treatment of Atrophic Osteopathies with Sodium Fluoride peutique de l'acide P-Butoxyphenylackthydroxamique (Traitement des osteopathies atrophiques par le fluorure (Droxaryl) en medecine physique) PAQUE, G.-R. (1969) http://ard.bmj.com/ de sodium) THJEBAUD, M. (1970) Schweiz. med. Wschr., J. beige Rhum. Mid. phys., 24, 273 100, 214 7 figs, bibl. (See Abstr. Wid Med. (1970), 44, 433) First Trial of Treatment of Inflammatory Rheumatism by Experience with Injection of Nitrogen Mustard into Joints Intra-articular Injection of 224Ra (Thorium) (Premiers ofPatients with Rheumatoid Arthritis HENDERSON, E. D., essais de traitement des rheumatismes inflammatoires par and NATHAN, F. F. (1969) Sth. med. J. (Bgham. Ala.), injection intra-articulaire de radium 224 (Thorium) 62, 1455 6 refs LOUYOT, P., MONTET, Y., LEGRAS, J., DIEBOLD, P., and (See Abstr. WId Med. (1970), 44, 550) POUREL, J. J. beige Rhum. Med. phys., 24, 265 6 figs on September 28, 2021 by guest. Protected

Role of Acid Secretion in Aspirin-induced Gastric Mucosal Treatment of Rheumatoid Arthritis with a Cytostatic Injury JABBARI, M., and VALBERG, L. S. (1970) Canad. Agent of the Ethylenimine Group (Behandlung der primar- med. Ass. J., 102, 178 1 fig., 25 refs chronischen Polyarthritis mit einem Zytostatikum der (See Abstr. Wid Med. (1970), 44, 605) Xthylenimin-Gruppe) CRUZ-FILHO, A. (1970) Z. Rheumaforsch., 29, 120 1 fig., 9 refs Absence of Gastrointestinal Bleeding following Adminis- tration of Salicylsalicylic Acid LEONARDS, J. R. (1969) J. Lab. clin. Med., 74, 911 13 refs Influence of the Plasma Depot-Cortisone Level on the (See Abstr. WId Med. (1970), 44, 417) Plasma Cortisol Level (Uber den Einfluss des Fluor- substituierten Depotcortisonplasmaspiegels auf das Plas- Genetic Nature of the Hypertensive Ocular Response to macortisol) EBERL, R., and ALTMANN, H. (1970) Z. Long-term Systemic Steroids GODEL, V., FEILER-OFRY, Rheumaforsch., 29, 94 2 figs, 9 refs V., and STEIN, R. (1970) Ann. Ophthal., 1, 426 4 figs, 9 refs Intrasynovial Corticosteroid Therapy in Arthritis HOL- (See Ophthal. Lit., vol. 24) LANDER, J. L. (1970) Maryland med. J., 19, 62 8 refs 586 Annals of the Rheumatic Diseases Ann Rheum Dis: first published as 10.1136/ard.29.5.569 on 1 September 1970. Downloaded from

A Comparison of Phenylbutazone and Flufenamic Acid in Changes in the Gastric Mucosa induced by Oral Ant- the Treatment ofAcute Gout DOUGLAS, G., and THOMP- rheumatic Therapy [In Yugoslav] ARSOv, D., DAV6EV, SON, M. (1970) Ann. phys. Med., 10, 275 3 refs P., VANOvSKI, B., PLAAEVSKI, A., STAVRI6, G., and GU6EVA, I. B. (1969) Acta med. iugosl., 23, 86 7 figs, Side-Effects of 6-Azauridine Triacetate in Rheumatoid 7 refs Arthritis ELIs, J., SLAVfK, M., and RA§KOVA, H. (1970) fig., 12 refs Clin. Pharmacol. Ther., 11, 404 1 Experimental Study of Chloroquine Retinopathy. (etude experimentale de la retinopathie par chloroquine) Double-Blind Clinical Trial of Analgesic Activity of BABEL, J., and ENGLERT, U. (1969) Bull. Soc. franc. Mefenamic Acid (Sperimentazione clinica a ceciti doppia Ophtal., 82, 491 10 figs, 14 refs sull'attivita analgesics dell'acido mefenamico) COL- TORTI, M., and SIMONE, A. Di (1970) Minerva med., 61, 1355 24 refs Systemic Lupus Erythematosus induced by Procainamide [In Swedish] WAAGSTEIN, F. (1970) Nord. Med., 83, Observations on the Use ofIndomethacin by the Parenteral 468 17 refs Route (Osservazioni sull'impiego dell'indometacina per via parenterale) ZEME, D., GUADAGNO, L., and BAR- SACCHI, M. (1970) Gazz. med. ital., 129, 29 11 refs Drug-induced Lupus Syndromes Leading Article (1970) Brit. med. J., 2, 192 11 refs Disorders of the Eyes due to Parenteral Gold Treatment of Rheumatoid Arthritis (Augenaffektionen bei parenteraler Intra-articular Chloroquine in Rheumatology (A propos Goldbehandlung der chronischen Polyarthritis) BEH- de la chloroquine intra-articulaire en rhumatologie) REND, T., and RODENHXUSER, J. H. (1969) Z. Rheuma- BOUwENOT, G., VYKYDAL, M., PEGRIMOVA, E., and forsch., 28, 441 3 figs, 12 refs VRUBLOVSKY, P. (1970) Rhumatologie, 22, 37 2 figs, 17 refs Intra-articular Radiogold Therapy (Intraartikulare Radio- FELLINGER, K., and THUMB, N. (1970) goldtherapie) by copyright. Z. Rheumaforsch., 29, 36 3 figs, 8 refs Management of Foot Problems in Arthritis SEDER, J. I. (1970) Cleveland Clin. Quart., 37, 111 7 figs Allergic-Cholestatic Hepatosis after Gold Therapy in a Case of Sero-negative Rheumatoid Arthritis (Allergische- Family Expectations and Arthritis Patient Compliance to cholestatische Hepatose nach Goldbehandlung einer a Hand Resting Splint Regimen OAKES, T. W., WARD, seronegativen progredient-chronischen Polyarthritis) J. R., GRAY, R. M., KLAUBER, M. R., and MOODY, P. M. WIONTZEK, H., and SCHMIDT, J. (1970) Z. Rheumaforsch., (1970) J. chron. Dis., 22, 757 16 refs 29, 46 9 refs Physical, Biological, and Clinical Bases of Pelotherapy (Part I) (La Drug Therapy of Ankylosing Spondylitis (Mud Treatment) (P61otherapie. Ses bases physiques, http://ard.bmj.com/ therapeutique medicamenteuse de la spondylarthrite biologiques et cliniques) GROS, M.-CH., SINGER, S., ankylosante) LOUYOT, P., MOUGIN, G., LEGRAS, B., ISAAC, J.-P., MATHEVON, G., and WAILLE, Y. (1970) MONTET, Y., COMBEBIAS, J.-F., POUREL, J., SIMON, J.-M., Rhumatologie, 22, 7 29 refs and DIEBOLD, P. (1970) Rev. Rhum., 37, 287 5 figs (Part II) LOUYOT, P., GAUCHER, A., MONTET, Y., POUREL, J., COMBEBIAS, J.-F., ROLAND, J., and STINES, Investigation of Radioactive Yttrium (90Y) for the Treat- J. (1970) Rev. Rhum., 37, 296 1 ref. ment of Chronic Knee Effusions PRITCHARD, H. L., BRIDGMAN, J. F., and BLEEHEN, N. M. (1970) Brit. J. 10 refs on September 28, 2021 by guest. Protected Treatment of Psychogenic Rheumatism (Behandeling van Radiol, 43, 466 1 fig., psychogeen reuma) VANSLYPE, J. (1969) J. beige Rhum. Med. phys., 24, 279 9 refs Gastric Blood Flow and its Distribution during Indo- methacin Administration EDLICH, R. F., NICOLOFF, Pharmacological Analysis of Aspirin COLLIER (1969) D. M., BORGEN, L., BUCHIN, R., and WANGENSTEEN, Advanc. Pharmacol. Chemother., 7, 333 0. H. (1970) Surg. Gynec. Obstet., 130 789, 1 fig., 7 refs

Ophthalmological Surveillance of Patients treated with Procainamide-induced Lupus Erythematosus in Man Synthetic Antimalarial Drugs: Electroretinographic De- FELLNER, M. J., ROZAN, M., KLAUS, M., and VAN HECKE, monstration of Toxic Impregnation of the Retina (Surveil- E. (1969) Arch. beiges Derm., 25, 417 1 fig., 42 refs lance ophtalmologique des malades traits par antipalu- deens de synthese: mise en evidence 61ectroretinogra- phique de l'impr6gnation retinienne toxique) RAMPON, Relationship of the Enterohepatic Cycle to Ulcerogenesis S., ROUHER, F., ALFIERI, R., SOLE, P., BUSSIERE, J.-L., in the Rat Small Bowel with Flufenamic Acid WAX, J., and SAUVEZIE, B. (1970) Rev. Rhum., 37, 233 1 fig., CLINGER, W. A., VARNFR, P., BASS, P., and WINDER, C. V. 2 refs (1970) Gastroenterology, 58, 772 4 figs, 33 refs Abstracts 587 Ann Rheum Dis: first published as 10.1136/ard.29.5.569 on 1 September 1970. Downloaded from

Surgery The patient was allowed up on the first or second day in a plaster cylinder, and at 5 weeks the plaster was removed, but 6 to 12 months were required to reach a Silicone Rubber Implants for Replacement of Arthritic or Destroyed Joints SWANSON, A. B. (1969) Hand. 1, 38 final state of recovery. A. R. TAYLOR The author has been responsible for the development of silicone rubber implants for the replacement of joints. Arthroplasty of the Knee YAMADA, K., and SmNDo, N. This material has great flexibility, very good force (1969) J. Bone Jt Surg., 51-A, 1480 dampening qualities, and biological inertness. The finger This paper describes a novel method of arthroplasty joint implant has now been in use for 4 years and has specifically designed to increase the range of painless proved satisfactory. But being a relatively soft material, knee flexion to allow the use of the squatting position it does not offer strong lateral stability and therefore on tatami mats. 54 patients with stiff knees mainly due control must be exercised over the joint until capsular to local fractures had an average range of knee joint repair or replacement has been achieved. motion of 34.40 before operation and 102.80 after A small number of wrist and elbow replacements have operation. Only one patient had decreased function. also been tested. K. M. BACKHOUSE The operation consists of two parts. A polyethylene membrane is shaped to make a sack to correspond to the Results of Treatment of Hip Disorders with Cup Arthro- antero-posterior pneumoarthrogram of the contralateral plasty JOHNSTON, R. C., and LARSON, C. B. (1969) knee. This rests within the potential suprapatellar pouch J. Bone Jt Surg., 51-A, 1461 with a fringe hanging down to lie in the tibiofemoral joint space. Within the sack a small polyethylene bag This report from the Orthopaedic Surgery Department containing 1 g. powdered magnetic iron is placed. An at the University ofIowa analyses data on 543 cup arthro- external magnetic field is used to move the bag containing plasties in 475 patients treated between 1950 and 1963; magnetic iron about within the sack and thus prevent 251 patients (294 hips) were reviewed at least 3 years adhesions developing within the suprapatellar bursa. after the operation. Most of the operations were per- The quadriceps tendon is lengthened by a Z-plasty formed for degenerative arthritis or complications of to achieve the required flexion. The authors calculate that trauma or congenital hip diseases. The paper sets out to a lengthening of 1 cm. is necessary for each 20° of flexion. by copyright. answer three questions; Postoperatively the knee is immobilized semiflexed at (1) What is involved in the operation in terms of risks, 120 to 1100 for several days. In the fourth or fifth post- time in the hospital, time on crutches, and time lost from operative week the polyethylene bag is removed through work. a small incision. (2) What kind of result can be expected in terms of pain No loss of stability has been noted, but extensor power relief and functional ability. recovers more quickly when the lengthening of the (3) How much time is required to obtain this result and quadriceps tendon is least. P. J. L. HOLT once obtained will the result last. The original should be consulted for details, but the results are incomplete because this is in part a retro- Recurrent Hemarthrosis after Prosthetic Knee Arthro- spective survey. P. J. L. HOLT plasty: Identification of Metal Particles in the Synovial http://ard.bmj.com/ Fluid Kmt ou, R. C., SCHUMACHER, H. R., JR., Double Osteotomy for the Painful Knee in Rheumatoid SBARBARO, J. L., and HOLLANDER, J. L. (1969) Arthr. Arthritis and Osteoarthritis BENJAMIN, A. (1969) J. and Rheum., 12, 520 Bone Jt Surg., 51-B, 694 3 figs, 4 refs Replacement of the tibial plateau by a stainless steel This paper describes the indications, the operative tech- prosthesis and the femoral condyle by a vitallium mould nique, and results of double osteotomy of the knee, in resulted in a particulate sediment in the synovial fluid. both rheumatoid arthritis and osteoarthrosis. This proved to be due to metallic particles which were on September 28, 2021 by guest. Protected The operation was performed for disabling pain that mainly extracellular. Similar particles were found in the did not respond to at least one year of conservative treat- synovial tissue. Little inflammatory reaction occurred. ment in patients who had 900 of movement in the absence X-ray diffraction patterns suggested that the stainless of gross deformity. steel prosthesis was the source of the metal. This is further A total of 150 knees were subjected to double osteo- evidence for the dissolution of metal joints particularly tomy, and 57 knees (36 with osteoarthrosis and 21 when the opposing surfaces are metallic and of dissimilar with rheumatoid arthritis) operated on between 1961 nature. The long-term effects of this are as yet unknown. to 1965 are reviewed. P. J. L. HOLT In many, the relief of pain was dramatic, there being no significant difference between the two groups. Only four rheumatoid patients considered that they had not Management of the Stiff Proximal Interphalangeal Joint benefited. Loss of movement amounting to 200 or more CURTIS, R. M. (1969) Hand, 1, 32 was noted in twenty knees, only five of which were in the rheumatoid arthritis group. Restoration of movement in a stiff digital interphalangeal At operation the femur was divided just distal to the joint can present somE of the greatest difficulties in hand upper border of the articular cartilage (intra-articularly) surgery. The differential diagnosis is wide and often un- and the tibia not more than 2-5 cm. distal to the joint. certain until surgical exposure is obtained. Limitation in 588 Annals of the Rheumatic Diseases Ann Rheum Dis: first published as 10.1136/ard.29.5.569 on 1 September 1970. Downloaded from flexion is often caused by blocking of the collateral shortening and the central slip destruction is well ad- ligaments. A method of repairing this condition is vanced. described, together with suggestions for treatment of [The anastomosis ofthe lateral bands and suture oftheir other causes of defective flexion. Among the treatments connecting fibres tend to restrict flexion of the inter- for repairing fixed-flexion deformity, operations for phalangeal joints and fine judgement is required to leave clearing an adherent volar plate or, if necessary, a volar enough sideways movement of the lateral bands to allow capsulectomy are described. for flexion of the distal interphalangeal joint.] This paper presents, in brief, an excellent review of the K. KUCZYNSKI possibilities for mobilization of the joint. MATEV, 1. (1964) Brit. J. last. Surg., 17, 281 K. M. BACKHOUSE -(1969) Hand, 1, 90 SOUTER, W. A. (1967) J. Bone Jt Surg., 49B, 710 Excision Arthroplasty of the Metacarpophalangeal Joints HARRISON, S. H. (1969) Hand, 1, 14 Role of Splenectomy in Felty's Syndrome O'NEILL, J. A., JR., Scorr, H. W., JR., BILLINGS, F. T., and FOSTER, J. H. Excision arthroplasty is often practised for the treatment (1968) Ann. Surg., 167, 18 of gross rheumatoid destruction of the metacarpophalan- geal joints and to establish a fibrous but mobile ankylosis. Felty's syndrome of active rheumatoid arthritis, spleno- By removing the destroyed joint, pain can be reduced or megaly, and leucopenia is reported in fourteen patients eliminated and the progress of the disease slowed. There seen during a period of 30 years at Vanderbilt University can also be a marked improvement in function, but there Hospital. is often a tendency for the fingers to drift back into severe Rheumatoid arthritis had been present for from 21 ulnar deviation. In order to control this tendency, half to 30 years and the total white count was between 500 the extensor digiti minimus is divided proximally and and 4,050 per cu. mm. There was a relative eosinophilia the proximal end is passed around the base ofthe proximal in one patient. Eleven had anaemia and ten hepatomegaly. phalanx of the little finger. It is then passed through the Half had weight loss and half had susceptibility to infec- dorsal hoods and sutured to the extensor indicis pro- tion. Two had lymphadenopathy but none had increased prius which is itself relocated into the first dorsal inter- skin pigmentation. The erythrocyte sedimentation rate osseous muscle. was elevated in all the patients. The seven patients who were tested had a positive latex- The results in 32 cases are stated to be good for up to by copyright. 3 years, but the authors also points out that this time is fixation test. There were no L.E.-cells in the five tested. too short for too definite conclusions. K. M. BACKHOUSE Of the ten with hepatomegaly, four had mild cirrhosis. Ten patients had marrow aspirated and this showed Correction of the Rheumatoid Boutonniere Deformity erythroid hyperplasia with maturation arrest in eight. A. W. B. (1969) J. Bone Jt Surg., 51A, 1309 The remaining two had marrow hypoplasia and these HEYWOOD, died later. In this paper from the Department of Orthopaedic Six patients, aged between 48 and 74 years, had Surgery of the University of Cape Town, a small series splenectomy and were followed postoperatively for from (9 fingers) is presented in which the treatment was by a 2 to 6 years. The remainder were aged 45 to 69 years method of tendon reconstruction which, it is suggested, and were followed for from 1 month to 13 years. Severe

is less likely to produce adhesions. A follow-up of from refractory hypersplenism was the sole indication for http://ard.bmj.com/ 1 to 3 years showed that this method was successful in a splenectomy. In four the white cell count became normal high proportion of cases. A Table is included, giving the and three had arthritic improvement. One with hypo- details of progress and the operative findings. plastic marrow showed no blood response but the arthritis The author stresses the scant attention paid to the became inactive. This patient died after 4 years with re- methods of tendon reconstruction in the rheumatoid current severe infections. Microscopy of the spleens variety of this condition. He recognizes three stages of showed chronic passive congestion. deformity: Of the remaining patients, four died with leucopenia of the and thrombocytopenia and with their arthritis unchanged (1) Pre-boutonniere synovitis proximal interphalan- on September 28, 2021 by guest. Protected geal joint, in which he advocates immediate synovectomy. or worse. The six patients who received steroids showed (2) Mobile boutonniere deformity, in which active but not no permanent improvement. C. D. D'A. FEARN passive extension is lost; this is treated by reconstruction of tendons. Pituitary Adrenal Responses to Surgical Stress in Patients (3) Fixed deformity, in which passive extension is lost; receiving Corticotrophin Treatment CARTER, M. E., here the treatment advocated consists of arthrodesis or and JAMES, V. H. T. (1970) Lancet, 1, 328 2 figs, 11 refs decompression of the joint. (See Abstr. WId Med. (1970), 44, 543) The described method of reconstruction consists of synovectomy of the joint and anastomosis of the dis- Surgery in Arthritis STEVENS, J. (1970) Geriatrics, 25, inserted ulnar lateral band to the radial one just distally 153 34 refs to the joint line. The middle slip is repaired by two mattress sutures close to the periosteum. Another suture Total Hip Replacement in England ROSENBERG, E. F. secures the transverse fibres connecting the lateral bands. (1970) J. Amer. med. Ass., 212, 611 2 figs A useful list ofreferences is given to which the following could be added: a review of 101 cases by Souter (1967) Smith-Petersen Mould Arthroplasty of the Hip: Results and two papers by Matev (1964, 1969) relevant to those after 12 to 21 Years LAW and MANZONI (1970) Proc. cases in which the lateral bands show some degree of roy. Soc. Med., 63, 583 Abstracts 589 Ann Rheum Dis: first published as 10.1136/ard.29.5.569 on 1 September 1970. Downloaded from

Spontaneous Subluxation of the First and Second Cervical (a) to women walking on the level with either flat- or Vertebrae in Rheumatoid Arthritis treated with Spinal high-heeled shoes (these made little difference to the Fusion SAWMILLER, S. R., and WILDE, A. H. (1970) joint force patterns in the knee except at heel strike Cleveland Clin. Quart., 37, 81 3 figs, 19 refs when there was an increase up to 24 per cent. (b) to men walking up and down a ramp or climbing stairs. The greatest value for muscle force was 564 lb for men in the High Tibial Osteotomy for Osteo-Arthritis of the Knee quadriceps femoris muscle during resisted muscle exten- HARRIS, W. R., and KOSTUIK, J. P. (1970) J. Bone Jt sion, i.e. in walking down a ramp. Lesser forces de- Surg., 52A, 330 veloped in other muscles or during other activities. [Only positive, compression joint force is treated here. Distraction force, as in the non-weight bearing phase of Proximal Tibial Osteotomy for Compartmental Tibio- knee joint activity, is ignored, although it may have femoral Osteoarthritis KYNE, P. J., (1970) N. Y. St. J physiological importance in, e.g. pumping, nutrition of Med., 70, 1059 2 figs, 8 refs cartilage.] A. ST. J. DIXON

Synovectomy and Debridement of the Knee in Rheumatoid Occupational Osteoarthropathy and Classical Ballet Arthritis. Part L. Historical Review GEENS, S. (1969) (Osteo-arthropathies professionnelles et danse classique) J. Bone Jt Surg., 51A, 617 NIKOLAEV, I. A., and NAJDENOV, S. (1970) Arch. Mal. Part II. Clinical and Roentgenographic Study of 31 Cases prof., 31, 39 8 refs GEENS, S., CLAYTON, M. L., LEIDHOLT, J. D., SMYTH, (See Abstr. WId Med. (1970), 44, 479) C. J., and BARTHOLOMEW, B. A. (1969) J. Bone Jt Surg., 51A, 626 Introduction to the Study of the Dynamic Factors of the Personality in Patients with Rheumatoid Arthritis (Intro- Synovectomy of the Metatarsophalangeal Joints in ducton a l'etude des facteurs dynamiques de la person- Rheumatoid Arthritis RAUNIO, P., and LAINE, H. (1970) nalite des polyarthritiques) RUELLE, M., TELLIER, E., Acta rheum. scand., 16, 12 1 fig., I ref. and COUDRON, J. (1969) J. beige Rhum. Mid. phys., 24,

255 13 refs by copyright.

The Injured Hand. Management of the Metacarpophalan- Personality Characteristics of Patients with Rheumatoid geal Joint: The Key to Hand Function KETCHUM, L. D., Arthritis POLLEY, H. F., SWENSON, W. M., and STEIN- ROBINSON, D. W., and MASTERS, F. W. (1970) J. Kans. HILBER, R. M. (1970) Psychosomatics, 11, 45 1 fig., 9 med. Soc., 71, 87 6 figs, 4 refs refs

Synovectomy of the Elbow in Rheumatoid Arthritis. Mental Abilities of Rheumatoid Patients and their Suita- Report of Five Cases TORGERSON, W. R., and LEACH, bility for Occupational Training under Defined Sanatorium R. E. (1970) J. Bone Jt Surg., 52A, 371 Conditions [In Polish] KOZLOWSKA, I., and STACHOWSKA, M. (1969) Reumatologia (Warsz.), 7, 355 6 refs http://ard.bmj.com/

Arthroplasty of the Elbow Joint using a Vitallium Pros- Economic Aspects of Arthritis and Rheumatism BROOKS, thesis CHATZIDAKIS, C. (1970) Int. Surg., 53, 119 7 ref, R. G., and BUCHANAN, W. W. (1970) Hlth Bull. (Edinb.), 6 figs 28, 42 4 refs

Fine Needle Biopsy Diagnosis in Nodular Pulmonary Other general subjects Amyloidosis DAHLGREN et al. (1970) Actapath. microbial. on September 28, 2021 by guest. Protected scand., 78A, 1 Function of the Knee Joint in Various Activities MORRI- SON, J. B. (1969) Bio-med. Engng., 4, 573 14 figs, 2 refs Remission of the Nephrotic Syndrome in Renal Amyloidosis LOWENSTEIN and GALLO (1970) New Engl. J. Med., In this paper (from the University of Strathclyde, 282, 128 Glasgow), the author takes joint force in the knee as approximately equal to the total force perpendicular to the plane of the tibial condyles during knee joint activi- An Amyloid-forming Nodular Syringocystadenoma ties. This and the forces in the cruciate ligaments and in JENNINGS and AHMED (1970) Arch. Derm., 101, 224 the main muscle groups acting on the knee were pre- viously calculated for men in normal level walking (see Osseous and Osteoarticular Manifestations in Walden- Bio-med. Engng., (1968) 3, 164), using a force plate on strom's Disease (Manifestations osseuses et osteo- which the subject walks, with cinephotography and articulaires au cours de la maladie de Waldenstrom. electromyography to correlate attitude of joint, phase of Aspect ophtalmologique et 6volutif) MWMIN, Y., walking, and muscle activity with computer analysis. BOUCHAT, J., and PATTIN, S. (1970) Rev. Rhum., 37, 309 The present study extends the observations 3 figs, bible. 590 Annals of the Rheumatic Diseases Ann Rheum Dis: first published as 10.1136/ard.29.5.569 on 1 September 1970. Downloaded from

Osteoarticular Manifestations of Acromegaly (Les mani- Defect Pseudarthroses BAADSGAARD (1969) Acta orthop. festations ost6o-articulaires de l'acrom6galie) SERRE, H., scand., 40, 689 SImoN, L., and SANY, J. (1970) Sem. Hop. Paris, 46, 1603 8 figs, 28 refs Comparison of the Dynamic Force-transmitting Properties of Subchondral Bone and Articular Cartilage RADIN, Arthroscopy and Endophotography for the Diagnosis and E. L., PAUL, I. L., and Lowy, M. (1970) J. Bone Jt Surg., Documentation of Knee Joint Injuries (Die Arthroskopie 52-A, 444 13 figs, 23 refs und Endophotographie zur Diagnostik und Dokumen- tation von Kniegelenksverletzungen) WRuus, 0. (1970) Scintigraphy of Joints with 99mTc-pertecbnetate (Die Wien. med. Wschr., 120, 126 19 figs, 13 refs Gelenksszintigraphie mit Tc99m-Pertechnetat) GOEBEL, R., EBER, O., WASCHER, H., HAYN, H., and KLEIN, G. Arthrography in the Diagnosis ofCalfPain LAPAYOWKER, (1970) Z. Rheumaforsch., 29, 75 9 figs, 7 refs M. S., CLIFF, M. M., and TOURTELLOTE, C. D. (1970) 6 15 refs 85Strontium Scintimetry of the Spine DEFIORE, J. C., Radiology, 95, 319 figs, LINDBERG, L., and RANAWAT, N. S. (1970) J. Bone Jt Surg., 52-A, 21 12 figs, 16 refs Challenge of the Painful Back-an Industrial and Medical Problem ROBERTSON, A. M. (1970) Occup. Med., 20, Palindromic Rheumatism (Le rhumatisme palindromique 42 1 fig., 18 refs (Apport de 16 observations et revue g6n6rale)) RENTER, J.-C., BRiGEON, CH., and BESSON, J. (1969) Rev. Rhum., Pain LIM (1970) Ann. Rev. Physiol., 32, 269 36, 583 78 refs Acute Synovial Rupture of the Knee-a Differential Meningococcal Meningitis complicated by Pericarditis, Diagnosis from Deep Vein Thrombosis HUGHES and Panophthalmitis, and Arthritis WILLIAMS, D. N., and PRIDIE (1970) Proc. roy. Soc. Med., 63, 587 GEDDES, A. M. (1970) Brit. med. J., 2, 93 10 refs

Dentated Iner Femoral Condyle SUTRO, C. J. (1969) Rheumatology as a Specialty in Medicine: A Personal Bull. Hosp. Jt Dis. (N. Y.), 30, 171 10 figs, 20 refs Appraisal DUTHIE, J. J. R. (1970) Scot. med. J., 15, 1.65 by copyright. http://ard.bmj.com/ on September 28, 2021 by guest. Protected