UROLOGY Lecture Course for Students of Medical Universities

Total Page:16

File Type:pdf, Size:1020Kb

UROLOGY Lecture Course for Students of Medical Universities A.A. Zebentaev, P.V. Plotnikov UROLOGY Lecture course for students of medical Universities Vitebsk, 2017 Ministry of Health Care of the Republic of Belarus Higher Educational Establishment “Vitebsk State Medical University” A.A. Zebentaev, P.V. Plotnikov UROLOGY Lecture course for students of medical Universities Рекомендовано учебно-методическим объединением по высшему медицинскому, фармацевтическому образованию Республики Беларусь в качестве учебно-методического пособия для студентов учреждений высшего образования, обучающихся по специальности 1-79 01 01 “Лечебное дело” Vitebsk, 2017 УДК 616.6(042.3/.4)=111 ББК 56.9я73 Z 42 Reviewed by: N.A. Nechiporenko, MD, PhD Grodno State Medical University Urology Dpt., Belarusian State Medical University, Minsk Zebentaev A.A. Z42 Urology: Lecture course for students of medical universities/ А.А. Zebentaev, P.V. Plotnikov. – Vitebsk: VSMU. - 2017. - 188p. ISBN-978-985-466-862-8 The content of this lecture course “Urology” for students of medical Univer- sities corresponds with basic educational plan and program, approved by Minis- try of Health Care of the Republic of Belarus. This book corresponds to the typ- ical educational program on specialty Urology and suitable for foreign students. This edition accumulates in a chort form the data covering the most of essential areas and all basic topics of urology. УДК 616.6(042.3/.4)=111 ББК 56.9я73 Confirmed and recommended for edition by the Central educational - methodi- cal Council of Vitebsk State Medical University in 16 November 2016, the protocol № 10. ISBN-978-985-466-862-8 © Zebentaev A.A., Plotnikov P.V., 2017 © VSMU Press, 2017 • CONTENTS CONTENTS . 3 ABBREVIATIONS .LIST . 7 1 .SYMPTOMS, .PHYSICAL .EXAMINATION AND. .INVESTIGATIONS .OF .THE . UROLOGICAL .PATIENTS . 11 1.1. Symptoms . 11 1.1.1. Systemic manifestations . 11 1.1.2. Flank pain . 13 1.1.3. Scrotal symptoms . 14 1.1.4. Penile and urethral symptoms . 15 1.1.5. Urinary incontinence . 16 1.1.6. Nocturia and nicturia . 17 1.2. Physical examination of the urological patient . 17 1.2.1. Abdominal examination of the patient with urological disease . 17 1.2.2. Digital rectal examination . 18 1.3. Urine examination . 18 1.3.1. Dipstick testing . 18 1.3.2. Urine microscopy . 19 1.3.3. Urine cytology . 20 1.4. Endoscopy . 20 1.4.1. Urethroscopy. 20 1.4.2. Cystoscopy. 20 1.4.3. Ureterorenoscopy . 21 1.5. Ultrasound. 21 1.6. Radiological imaging . 24 1.6.1. A plain film . 24 1.6.2. Intravenous urography . 24 1.6.3. Retrograde urography . 25 1.6.4. Antegrade urography . 25 1.6.5. Cystography . 25 1.6.6. Urethrography . 25 1.7. Computed tomography . 26 1.8. Magnetic resonance tomography . 27 1.9. Radioisotope imaging and renal function assessement . 28 1.10. Uroflowmetry. 30 1.11. Cystometry, pressure flow studies and videocystometry . 30 1.12. PSA . 31 4 CONTENTS 2 .STONE .DISEASE . 32 2.1. Kidney stones . 32 2.2. Ureteric stones . 37 2.3. Bladder stones . 39 3 .BENIGN .PROSTATIC .HYPERPLASIA . 41 4 ANOMALIES. .OF .THE .GENITOURINARY .TRACT . 47 4.1. Renal and ureteral anomalies . 47 4.1.1. Horseshoe kidney . 47 4.1.2. Ectopic kidney . 47 4.1.3. Renal agenesis. 47 4.1.4. Cystic kidney disease . 48 4.1.5. Upper urinary tract duplication . 49 4.1.6. Pelviureteric junction obstruction . 50 4.1.7. Vesicoureteric reflux . 51 4.1.8. Ectopic ureter . 51 4.1.9. Ureterocele. 52 4.2. Urethral anomalies . 53 4.2.1. Hypospadias . 53 4.2.2. Posterior urethral valves . 54 4.3. Bladder exstrophy and epispadias . 54 4.3.1. Bladder exstrophy . 54 4.3.2. Primary epispadias. 55 4.4. Bladder abnormalities . 56 4.4.1. Persistent urachus . 56 4.4.2. Contracture of the bladder neck . 56 4.4.3. Dilated fetal bladder . 57 4.4.4. Congenital megacystis . 57 4.4.5. Bladder hypoplasia . 58 4.4.6. Bladder agenesis. 58 4.4.7. Bladder diverticulum . 58 4.4.8. Bladder duplication. 59 4.5. Penile abnormalities. 59 4.5.1. Phimosis . 59 4.5.2. Aphallia . 60 4.5.3. Diphallia . 60 4.5.4. Inconspicuous penis . 61 4.5.5. Micropenis . 62 4.5.6. Penile curvature . 63 4.6. Testicular abnormalities . 64 4.6.1. Cryptorchidism . 64 UROLOGY 5 5 .ONCOUROLOGY . 65 5.1. Prostate cancer . 65 5.2. Bladder cancer . 77 5.3. Renal pelvic and ureteral cancers . 85 5.4. Renal tumors . 87 5.4.1. Benign renal masses. 87 5.4.2. Renal cell carcinoma. 88 5.5. Testicular cancer . 93 5.6. Penile neoplasms . 97 5.6.1. Viral-related and premalignant lesions. 97 5.6.2. Penile cancer. 98 5.7. Urethral cancer . 100 6 .TRAUMA .TO .THE .URINARY .TRACT . 103 6.1. Renal injuries . 103 6.2. Ureteric injuries . 106 6.3. Bladder and ureteric injuries associated with pelvic fractures . 108 6.4. Bladder injuries . 109 6.5. Urethral injuries . 110 6.5.1. Posterior urethral injuries in males. 110 6.5.2. Anterior urethral injuries in males . 111 6.5.3. Urethral injuries in females. 112 6.6. Testicular injuries . 113 6.7. Penile injuries . 113 6.7.1. Penile amputation . 113 6.7.2. Penile fracture . 114 7 .EMERGENCIES . 115 7.1. Acute urinary retention . 115 7.1.1. Aсute urinary retention in male . 115 7.1.2. Bladder outlet obstruction and retention in women . 117 7.2. Torsion of the testis and testicular appendages . 118 7.3. Paraphimosis . 118 7.4. Malignant ureteric obstruction. 119 8 .URINARY .TRACT .INFECTIONS . 120 8.1. Cystitis. 122 8.2. Urethritis. 123 8.3. Recurrent urinary tract infection . 124 8.4. Pyelonephritis . 125 8.4.1. Acute pyelonephritis . 125 8.4.2. Emphysematous pyelonephritis . 127 8.4.3. Purulent forms of pyelonephritis . ..
Recommended publications
  • Pregnancy in Non-Communicating Unicornuate Uterus
    THIEME 640 Case Report Pregnancy in Non-Communicating Unicornuate Uterus: Diagnosis Difficulty and Outcomes – aCaseReport Gestação em útero unicorno não comunicante: dificuldadediagnósticaedesfechos– relato de caso Camila Silveira de Souza1 Gabriela Gindri Dorneles1 Giana Nunes Mendonça1 Caroline Mombaque dos Santos1 Francisco Maximiliano Pancich Gallarreta1 Cristine Kolling Konopka1 1 Department of Gynecology and Obstetrics, Universidade Federal de Address for correspondence Cristine Kolling Konopka, MD, PhD, Santa Maria, Santa Maria, Rio Grande do Sul, Brazil Universidade Federal de Santa Maria, Avenida Roraima, 1000, prédio 26, sala 1333, Camobi, 97105-900, Santa Maria, RS, Brazil Rev Bras Ginecol Obstet 2017;39:640–644. (e-mail: [email protected]). Abstract Approximately 1 in every 76,000 pregnancies develops within a unicornuate uterus with a rudimentary horn. Müllerian uterus anomalies are often asymptomatic, thus, the diagnosis is a challenge, and it is usually made during the gestation or due to its complications, such as uterine rupture, pregnancy-induced hypertension, antepartum, Keywords postpartum bleeding and intrauterine growth restriction (IUGR). In order to avoid ► uterus unnecessary cesarean sections and the risks they involve, the physicians should ► abnormalities consider the several approaches and for how long it is feasible to perform labor ► pregnancy induction in suspected cases of pregnancy in a unicornuate uterus with a rudimentary ► parturition horn, despite the rarity of the anomaly. This report describes a case of a unicornuate ► pregnancy uterus in which a pregnancy developed in the non-communicating rudimentary horn complications and the consequences of the delayed diagnosis. Resumo Aproximadamente 1 em cada 76 mil gestações se desenvolvem em útero unicorno sem comunicação com o colo uterino.
    [Show full text]
  • Pregnancy in a Unicornuate Uterus with Non-Communicating Rudimentary Horn: Diagnostic and Therapeutic Challenges
    Contents lists available at Vilnius University Press Acta medica Lituanica ISSN 1392-0138 eISSN 2029-4174 2020. Vol. 27. No 2, pp. 84–89 DOI: https://doi.org/10.15388/Amed.2020.27.2.6 Pregnancy in a Unicornuate Uterus with Non-Communicating Rudimentary Horn: Diagnostic and Therapeutic Challenges Ratko Delić Department of Obstetrics and Gynecology, General and Teaching Hospital Celje, Slovenia Abstract. Unicornuate uterus with non-communicating rudimentary horn is a type of congenital uterine abnormality that occurs as a consequence of the arrested development of one of the two Müllerian ducts. Patients with unicornuate uterus have increased incidence of obstetric and gynaecological complications. We present a report of a clinical case of a 28-years-old female, who was referred to the hospital for evalu- ation of her infertility. The patient reported primary infertility and inability to conceive after 3-year period of regular unprotected intercourse. Transvaginal ultrasound, along with the preoperative evaluation were completed; however, no anomalies or irregularities were reported. Combined diagnostic simultaneous laparoscopy and hysteroscopy were performed to establish the diag- nosis of unicornuate uterus with non-communicating rudimentary horn. The patient conceived spontaneously after diagnostic laparoscopy and hysteroscopy. During and after pregnancy, our patient and her child experienced numerous complications (cervical incompetence, acute chorioamnionitis, acute fetal distress, pneumonia, septic shock) and procedures (cer- vical cerclage, urgent cesarean section, intensive care unit treatment) without significant fetal or maternal compromise. Keywords: infertility, unicornuate uterus, pregnancy, cervical incompetence, sepsis Nėštumas vienaragėje gimdoje su rudimentiniu nesusijungusiu ragu Santrauka. Vienaragė gimda su rudimentiniu nesusijungusiu ragu yra įgimta makšties anomalija, atsiradusi sutrikus vieno iš dviejų Miulerio latakų vystymuisi.
    [Show full text]
  • Prevalence and Incidence of Rare Diseases: Bibliographic Data
    Number 1 | January 2019 Prevalence and incidence of rare diseases: Bibliographic data Prevalence, incidence or number of published cases listed by diseases (in alphabetical order) www.orpha.net www.orphadata.org If a range of national data is available, the average is Methodology calculated to estimate the worldwide or European prevalence or incidence. When a range of data sources is available, the most Orphanet carries out a systematic survey of literature in recent data source that meets a certain number of quality order to estimate the prevalence and incidence of rare criteria is favoured (registries, meta-analyses, diseases. This study aims to collect new data regarding population-based studies, large cohorts studies). point prevalence, birth prevalence and incidence, and to update already published data according to new For congenital diseases, the prevalence is estimated, so scientific studies or other available data. that: Prevalence = birth prevalence x (patient life This data is presented in the following reports published expectancy/general population life expectancy). biannually: When only incidence data is documented, the prevalence is estimated when possible, so that : • Prevalence, incidence or number of published cases listed by diseases (in alphabetical order); Prevalence = incidence x disease mean duration. • Diseases listed by decreasing prevalence, incidence When neither prevalence nor incidence data is available, or number of published cases; which is the case for very rare diseases, the number of cases or families documented in the medical literature is Data collection provided. A number of different sources are used : Limitations of the study • Registries (RARECARE, EUROCAT, etc) ; The prevalence and incidence data presented in this report are only estimations and cannot be considered to • National/international health institutes and agencies be absolutely correct.
    [Show full text]
  • Orphanet Report Series Rare Diseases Collection
    Marche des Maladies Rares – Alliance Maladies Rares Orphanet Report Series Rare Diseases collection DecemberOctober 2013 2009 List of rare diseases and synonyms Listed in alphabetical order www.orpha.net 20102206 Rare diseases listed in alphabetical order ORPHA ORPHA ORPHA Disease name Disease name Disease name Number Number Number 289157 1-alpha-hydroxylase deficiency 309127 3-hydroxyacyl-CoA dehydrogenase 228384 5q14.3 microdeletion syndrome deficiency 293948 1p21.3 microdeletion syndrome 314655 5q31.3 microdeletion syndrome 939 3-hydroxyisobutyric aciduria 1606 1p36 deletion syndrome 228415 5q35 microduplication syndrome 2616 3M syndrome 250989 1q21.1 microdeletion syndrome 96125 6p subtelomeric deletion syndrome 2616 3-M syndrome 250994 1q21.1 microduplication syndrome 251046 6p22 microdeletion syndrome 293843 3MC syndrome 250999 1q41q42 microdeletion syndrome 96125 6p25 microdeletion syndrome 6 3-methylcrotonylglycinuria 250999 1q41-q42 microdeletion syndrome 99135 6-phosphogluconate dehydrogenase 67046 3-methylglutaconic aciduria type 1 deficiency 238769 1q44 microdeletion syndrome 111 3-methylglutaconic aciduria type 2 13 6-pyruvoyl-tetrahydropterin synthase 976 2,8 dihydroxyadenine urolithiasis deficiency 67047 3-methylglutaconic aciduria type 3 869 2A syndrome 75857 6q terminal deletion 67048 3-methylglutaconic aciduria type 4 79154 2-aminoadipic 2-oxoadipic aciduria 171829 6q16 deletion syndrome 66634 3-methylglutaconic aciduria type 5 19 2-hydroxyglutaric acidemia 251056 6q25 microdeletion syndrome 352328 3-methylglutaconic
    [Show full text]
  • Print This Article
    International Journal of Research in Medical Sciences Lekha KS et al. Int J Res Med Sci. 2021 Feb;9(2):364-370 www.msjonline.org pISSN 2320-6071 | eISSN 2320-6012 DOI: https://dx.doi.org/10.18203/2320-6012.ijrms20210050 Original Research Article Genital ambiguity: a cytogenetic evaluation of gender K. S. Lekha1*, V. Bhagyam2, P. D. Varghese3, M. Manju2 1Department of Anatomy, Government Medical College Thrissur, Kerala, India 2Department of Anatomy, Government Medical College Kozhikode, Kerala, India 3Department of Anatomy, Government Medical College Alappuzha, Kerala, India Received: 15 December 2020 Accepted: 31 December 2020 *Correspondence: Dr. K. S. Lekha, E-mail: [email protected] Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Background: Genital ambiguity is a complex genetic disorder of sexual differentiation into male or female. The purpose of the present study is to correlate the sex of rearing with the genetic sex and to find out the prevalence of chromosomal anomalies in patients with ambiguous genitalia. The findings can help in proper diagnosis, genetic counselling, and the reassignment of sex, if necessary. Methods: In this cross-sectional study, 22 patients from north Kerala, ranging in age from 17 days to 17 years, were included. All cases were subjected to the following: a detailed history, physical examination, evaluation of clinical data, and cytogenetic analysis. Based on the standard protocol, peripheral blood lymphocyte culture was done.
    [Show full text]
  • Management of Reproductive Tract Anomalies
    The Journal of Obstetrics and Gynecology of India (May–June 2017) 67(3):162–167 DOI 10.1007/s13224-017-1001-8 INVITED MINI REVIEW Management of Reproductive Tract Anomalies 1 1 Garima Kachhawa • Alka Kriplani Received: 29 March 2017 / Accepted: 21 April 2017 / Published online: 2 May 2017 Ó Federation of Obstetric & Gynecological Societies of India 2017 About the Author Dr. Garima Kachhawa is a consultant Obstetrician and Gynaecologist in Delhi since over 15 years; at present, she is working as faculty at the premiere institute of India, prestigious All India Institute of Medical Sciences, New Delhi. She has several publications in various national and international journals to her credit. She has been awarded various national awards, including Dr. Siuli Rudra Sinha Prize by FOGSI and AV Gandhi award for best research in endocrinology. Her field of interest is endoscopy and reproductive and adolescent endocrinology. She has served as the Joint Secretary of FOGSI in 2016–2017. Abstract Reproductive tract malformations are rare in problems depend on the anatomic distortions, which may general population but are commonly encountered in range from congenital absence of the vagina to complex women with infertility and recurrent pregnancy loss. defects in the lateral and vertical fusion of the Mu¨llerian Obstructive anomalies present around menarche causing duct system. Identification of symptoms and timely diag- extreme pain and adversely affecting the life of the young nosis are an important key to the management of these women. The clinical signs, symptoms and reproductive defects. Although MRI being gold standard in delineating uterine anatomy, recent advances in imaging technology, specifically 3-dimensional ultrasound, achieve accurate Dr.
    [Show full text]
  • Perineal Lipoma Mimicking an Accessory Penis with Scrotum
    International Surgery Journal Jabbal HS et al. Int Surg J. 2017 Apr;4(4):1463-1465 http://www.ijsurgery.com pISSN 2349-3305 | eISSN 2349-2902 DOI: http://dx.doi.org/10.18203/2349-2902.isj20171160 Case Report Perineal lipoma mimicking an accessory penis with scrotum Harmandeep S. Jabbal*, Dhirendra D. Wagh Department of Surgery, Jawaharlal Nehru Medical College, Sawangi (Meghe), Wardha, Maharashtra, India Received: 18 January 2017 Accepted: 16 February 2017 *Correspondence: Dr. Harmandeep S. Jabbal, E-mail: [email protected] Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT A case of accessory penis with scrotum in a 4 months old boy is reported because of its rarity. The infant presented with a tumour mimicking an accessory penis with scrotum between the normal sited scrotum and anus. Both testes had descended into the scrotum. After complete evaluation, there was no other urological anomaly. The tumour was excised and the histo-pathological findings of the tumor indicated a perineal lipoma. An overview of normal development of male external genitalia has been provided and the deranged mechanism resulting in this anomaly has been reviewed with hypothesis regarding etiology of accessory scrotum. Keywords: Accessory penis, Accessory scrotum, Congenital urogenital deformities, Perineal lipoma INTRODUCTION palpation in each hemi-scrotum. Another mass of size 3 cm x 1.5 cm was situated between the normally sited Accessory scrotum is considered the rarest of all scrotum and the anal orifice.
    [Show full text]
  • Research Opinions in Animal & Veterinary Sciences
    www.roavs.com EISSN: 2223-0343 RESEARCH OPINIONS IN ANIMAL & VETERINARY SCIENCES Diphallia and double scrota in a donkey: A case report A.M. Abu-Seida* and F.M. Torad Department of Surgery, Anesthesiology & Radiology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt Abstract Diphallia and double scrota are rare congenital anomalies. This report records, for the first time, the gross pathological findings of a rare case of diphallia and double scrota in a two-year-old donkey. On physical examination of the donkey, double peni, double prepuces, double scrota and two testes were observed. The two peni were directed opposite to each other at the caudal ventral midline. The posterior penis was the functional one and appeared normal in structure. This penis had ventral deviation and was displaced caudally to the posterior scrotum and testes. The testes were atrophied, asymmetrical and located anterior to the posterior penis in a transverse plan. The anterior penis was not functional, rudimentary, replaced by a fibrous band, fixed to the prepuce and had normal cranial direction. The anterior prepuce was well developed with preputial orifice. The anterior scrotum was rudimentary, empty and located posterior to the anterior penis. Two rudimentary teats were also seen between anterior prepuce and scrotum. Keywords: Diphallia; double scrota; donkey To cite this article: Abu-Seida AM and FM Torad, 2014. Diphallia and double scrota in a donkey: A case report. Res. Opin. Anim. Vet. Sci., 4(3), 117-119. Introduction structure in the middle of the two scrota contained the urinary bladder and a loop of small intestine.
    [Show full text]
  • Abnormalities of the External Genitalia and Groins Among Primary School Boys in Bida, Nigeria
    Abnormalities of the external genitalia and groins among primary school boys in Bida, Nigeria. Adedeji O Adekanye1,2, Samuel A Adefemi1,3, Kayode A Onawola1,2, John A James1,2, Ibrahim T Adeleke1,4, Mark Francis1,2, Ezekiel U Sheshi1,3, Moses E Atakere1,5, Abdullahi D Jibril1,5 1. Centre for Health & Allied Researches (CHAR), Federal Medical Centre Bida, Nigeria 2. Department of Surgery, Federal Medical centre, Bida Nigeria 3. Department of Family Medicine, Federal Medical centre, Bida Nigeria 4. Department of Health Information management, Federal Medical centre, Bida Nigeria 5. Department of Obstetrics & Gynaecology, Federal Medical centre, Bida Nigeria Abstract Background: Abnormalities of the male external genitalia and groin, a set of lesions which may be congenital or acquired, are rather obscured to many kids and their parents and Nigerian health care system has no formal program to detect them. Objectives: To identify and determine the prevalence of abnormalities of external genitalia and groin among primary school boys in Bida, Nigeria. Methods: This was a cross-sectional study of primary school male pupils in Bida. A detailed clinical examination of the external genitalia and groin was performed on them. Results: Abnormalities were detected in 240 (36.20%) of the 663 boys, with 35 (5.28%) having more than one abnormality. The three most prevalent abnormalities were penile chordee (37, 5.58%), excessive removal of penile skin (37, 5.58%) and retractile testis (34, 5.13%). The prevalence of complications of circumcision was 15.40% and included excessive residual foreskin, exces- sive removal of skin, skin bridges and meatal stenosis.
    [Show full text]
  • Congenital Penile Malformations: Dartos and Androgens Ghent University Hospital Maintains Database of Children Undergoing Surgery for CPM
    Congenital penile malformations: Dartos and androgens Ghent University Hospital maintains database of children undergoing surgery for CPM Dr. Anne-Françoise Human male and female genitalia originate from a Spinoit common identical genital tubercle. Sexual Pediatric and differentiation into male or female starts around the Reconstructive 8th gestational week, under the influence of the Urology Sex-determining Region Y (SRY) gene12,13. With Robotics progressive differentiation of the undifferentiated Ghent University gonad into testicle, androgen production is started, Hospital along with Anti-Müllerian Hormone (AMH), allowing Ghent (BE) further differentiation into male genitalia. Initial differentiation of the bi-potential undifferentiated gonad is androgen-independent until a testicle is formed. Further development of the male genitalia is Over the past decades, epidemiologic studies have androgen dependent, while regression of female shown increasing incidence of Congenital Penile (Müllerian) primitive structures is dependent on AMH Malformations (CPMs)1-3. Anomalies of the male production. external genitalia may be confined to the clinical appearance, or might be the first clue indicating Under the influence of androgens, the genital tubercle further underlying disorders that require evaluation. grows into the penis14. Hypospadias is the most frequent congenital penile One of the questions that arise is whether DT defect affecting the external male genitalia, with an development is hormone-dependent. It is known that incidence around one in 250 male newborns2,4. It is the development of the male external genitalia occurs therefore the most studied CPM. under hormonal influence so it seems logical that disturbances in the hormonal mechanisms can have Buried penis (BP) is another CPM frequently any influence on DT patterns.
    [Show full text]
  • Meeting Report on the NIDDK/AUA Workshop on Congenital Anomalies of External Genitalia: Challenges and Opportunities for Translational Research
    UCLA UCLA Previously Published Works Title Meeting report on the NIDDK/AUA Workshop on Congenital Anomalies of External Genitalia: challenges and opportunities for translational research. Permalink https://escholarship.org/uc/item/1vk2c98g Journal Journal of pediatric urology, 16(6) ISSN 1477-5131 Authors Stadler, H Scott Peters, Craig A Sturm, Renea M et al. Publication Date 2020-12-01 DOI 10.1016/j.jpurol.2020.09.012 Peer reviewed eScholarship.org Powered by the California Digital Library University of California Journal of Pediatric Urology (2020) 16, 791e804 Review Article Meeting report on the NIDDK/AUA Workshop on Congenital Anomalies of External Genitalia: challenges and opportunities for translational research* aDepartment of Skeletal Biology, Shriners Hospital for Children, a, ,1 b,c, ,1 d,1 3101 SW Sam Jackson Park Road, H. Scott Stadler *** , Craig A. Peters ** , Renea M. Sturm , b e f,g Portland, OR, Oregon Health & Linda A. Baker , Carolyn J.M. Best , Victoria Y. Bird , Science University, Department of h i j Orthopaedics and Rehabilitation, Frank Geller , Deborah K. Hoshizaki , Thomas B. Knudsen , i k l, ,1 Portland, 97239, OR, USA Jenna M. Norton , Rodrigo L.P. Romao , Martin J. Cohn * b Department of Urology, Summary parents, and short interviews to determine familial University of Texas Southwestern, 5323 Harry Hines Blvd., Dallas, Congenital anomalies of the external genitalia penetrance (small pedigrees), would accelerate 75390-9110, TX, USA (CAEG) are a prevalent and serious public health research in this field. Such a centralized datahub concern with lifelong impacts on the urinary func- will advance efforts to develop detailed multi- cPediatric Urology, Children’s tion, sexual health, fertility, tumor development, dimensional phenotyping and will enable access to Health System Texas, University of and psychosocial wellbeing of affected individuals.
    [Show full text]
  • Intersex 101
    INTERSEX 101 With Your Guide: Phoebe Hart Secretary, AISSGA (Androgen Insensitivity Syndrome Support Group, Australia) And all‐round awesome person! WHAT IS INTERSEX? • a range of biological traits or variations that lie between “male” and “female”. • chromosomes, genitals, and/or reproductive organs that are traditionally considered to be both “male” and “female,” neither, or atypical. • 1.7 – 2% occurrence in human births REFERENCE: Australians Born with Atypical Sex Characteristics: Statistics & stories from the first national Australian study of people with intersex variations 2015 (in press) ‐ Tiffany Jones, School of Education, University of New England (UNE), Morgan Carpenter, OII Australia, Bonnie Hart, Androgyn Insensitivity Syndrome Support Group Australia (AISSGA) & Gavi Ansara, National LGBTI Health Network XY CHROMOSOMES ..... Complete Androgen Insensitivity Syndrome (CAIS) ..... Partial Androgen Insensitivity Syndrome (PAIS) ..... 5‐alpha‐reductase Deficiency (5‐ARD) ..... Swyer Syndrome/ Mixed Gonadal Dysgenesis (MGD) ..... Leydig Cell Hypoplasia ..... Persistent Müllerian Duct Syndrome ..... Hypospadias, Epispadias, Aposthia, Micropenis, Buried Penis, Diphallia ..... Polyorchidism, Cryptorchidism XX CHROMOSOMES ..... de la Chapelle/XX Male Syndrome ..... MRKH/Vaginal (or Müllerian) agenesis ..... XX Gonadal Dysgenesis ..... Uterus Didelphys ..... Progestin Induced Virilization XX or XY CHROMOSOMES ...... Congenital Adrenal Hyperplasia (CAH) ..... Ovo‐testes (formerly called "true hermaphroditism") ....
    [Show full text]