Clinical Drug Monitoring Reference Guide Clinical Drug Monitoring Test List with Test Codes

Drug Class P P,D,M P,D D,M D Drug Class P P,D,M P,D D,M D Drug Class P P,D,M P,D D,M D

Alcohol Metabolites 90079 16910 92142 16217 Cocaine Metabolite 92225 70248 16888 90082 16916 Naltrexone 93753

Amphetamines 92222 70245 16885 70209 16913 Eszopiclone 91251 Opiates 92230 18991 16891 70237* 16298*

Amphetamines Fentanyl 36278 36279 36280 18996 16900 Oxycodone 92231 18992 16892 70238 16920 91590 91589 92484 92483 with Reflex d/l Isomers Gabapentin 70205 16904 Phencyclidine 92232 18993 16893 90083 16921 Antidepressants (urine) 94032 Heroin Metabolite 92226 90081 16911 90333 90329 Pregabalin 70208 16908 Antidepressants (serum) 94031 Marijuana Metabolite 92227 18989 16889 70233 16917 Propoxyphene 92233 18995 16894 70239 16922 Antipsychotics (urine) 94528 MDMA/MDA 92228 90078 16909 90334 90331 Synthetic Cannabinoids 93027 Antipsychotics (serum) 94529 Meperidine 70206 16905 Synthetic Stimulants 90322 Barbiturates 92223 70246 16886 70230 16912 Methadone Metabolite 92229 18990 16890 70234 16918 Tapentadol 90244 90243 Benzodiazepines 92224 70247 16887 70231 16914 Methamphetamine Tramadol 70207 16906 90319 Buprenorphine 16207 70249 16901 18998 16213 d/l Isomers Tricyclic Antidepressants 70204 16903 Buprenorphine 93093 93094 Methylphenidate 90247 90246 with Naloxone Zolpidem 91258 Mitragynine 39241 39240 Carisoprodol 18999 16902 *Includes oxycodone drug class Test Profiles

Profile Name Base Profile Profile 1 Profile 2 Profile 3 Profile 4 Profile 5 Profile 6 Profile 7 Profile 8 and Test Codes 16260 16259 16457 92466 92450 92451 92458 92459 92467 92453 92461 16855 16854 16456 92468 92454 92462 90347 90348 92455 90318 92463 92456 92464 92457 92465 92489 92490

Drug Class P P,D,M P,D P P,D,M P,D,M P,D P,D P P,D,M P,D P P,D,M P,D P P,D,M P,D P P,D,M P,D,M P,D P,D P,D,M P,D P,D,M P,D P,D,M P,D Alcohol Metabolites/ETG ALC ALC ALC ALC ALC ALC Amphetamines AMP AMP AMP AMP AMP AMP AMP AMP AMP AMP AMP AMP AMP AMP AMP AMP AMP AMP Amphetamines d/l Isomers ADL ADL ADL ADL Barbiturates BAR BAR BAR BAR BAR BAR BAR BAR BAR BAR BAR BAR BAR BAR BAR BAR BAR Benzodiazepines BEN BEN BEN BEN BEN BEN BEN BEN BEN BEN BEN BEN BEN BEN BEN BEN BEN BEN BEN BEN BEN BEN BEN BEN BEN Buprenorphine BUP BUP Cocaine Metabolite COC COC COC COC COC COC COC COC COC COC COC COC COC COC COC COC COC COC COC COC COC COC COC COC COC Heroin Metabolite HER HER HER HER HER HER Marijuana Metabolite MAR MAR MAR MAR MAR MAR MAR MAR MAR MAR MAR MAR MAR MAR MAR MAR MAR MAR MAR MDMA/MDA MDM MDM Methadone Metabolite MTH MTH MTH MTH MTH MTH MTH MTH MTH MTH MTH MTH MTH MTH MTH MTH MTH MTH MTH MTH Opiates OPI OPI OPI OPI OPI OPI OPI OPI OPI OPI OPI OPI OPI OPI OPI OPI OPI OPI OPI OPI OPI OPI OPI OPI OPI OPI OPI OPI Oxycodone OXY OXY OXY OXY OXY OXY OXY OXY OXY OXY OXY OXY OXY OXY OXY OXY OXY OXY OXY OXY OXY OXY OXY OXY OXY OXY OXY OXY Phencyclidine PCP PCP PCP PCP PCP PCP PCP PCP PCP PCP

P = Presumptive D = Definitive M = medMATCH®

Page 2 Clinical Drug Monitoring Test Profiles

Profile 1 with Amphetamines Base Profile Profile 1 d/l Isomers Profile 2 16260 (P), 16259 (P,D,M), 16457 (P,D) 92466 (P), 92450 (P,D,M), 92458 (P,D) 92451 (P,D,M), 92459 (P,D) 92467 (P), 92453 (P,D,M), 92461 (P,D)

Benzodiazepines Amphetamines Amphetamines with Reflex d/l Isomers Methadone Metabolite Cocaine Metabolite Barbiturates Barbiturates Opiates Opiates Benzodiazepines Benzodiazepines Oxycodone Oxycodone Cocaine Metabolite Cocaine Metabolite Marijuana Metabolite Marijuana Metabolite Methadone Metabolite Methadone Metabolite Opiates Opiates Oxycodone Oxycodone Phencyclidine Phencyclidine

Profile 5 with Amphetamines Profile 3 Profile 4 Profile 5 d/l Isomers 16855 (P), 16854 (P,D,M), 16456 (P,D) 92468 (P), 92454 (P,D,M), 92462 (P,D) 90347 (P), 90348 (P,D,M), 90318 (P,D) 92455 (P,D,M), 92463 (P,D)

Amphetamines Amphetamines Amphetamines Amphetamines with Reflex d/l Isomers Benzodiazepines Barbiturates Barbiturates Barbiturates Cocaine Metabolite Benzodiazepines Benzodiazepines Benzodiazepines Marijuana Metabolite Cocaine Metabolite Cocaine Metabolite Cocaine Metabolite Opiates Methadone Metabolite Marijuana Metabolite Marijuana Metabolite Oxycodone Opiates Methadone Metabolite Methadone Metabolite Oxycodone Opiates Opiates Phencyclidine Oxycodone Oxycodone

Profile 6 Profile 7 Profile 8 92456 (P,D,M), 92464 (P,D) 92457 (P,D,M), 92465 (P,D) 92489 (P,D,M), 92490 (P,D) For healthcare professionals Alcohol Metabolites/EtG Alcohol Metabolites/EtG Alcohol Metabolites/EtG Amphetamines Amphetamines Amphetamines seeking assistance with Barbiturates Barbiturates Benzodiazepines Benzodiazepines Benzodiazepines Buprenorphine interpreting results, please Cocaine Metabolite Cocaine Metabolite Cocaine Metabolite contact a Quest Diagnostics Heroin Metabolite Heroin Metabolite Heroin Metabolite Marijuana Metabolite Marijuana Metabolite Marijuana Metabolite Toxicology Specialist Methadone Metabolite Methadone Metabolite MDMA/MDA Opiates Opiates Opiates at 1.877.40.R X TOX Oxycodone Oxycodone Oxycodone (1.877.407.9869), Phencyclidine M–F 8:00 AM to

P = Presumptive D = Definitive M = medMATCH® 10:00 PM ET.

Page 3 Clinical Drug Monitoring Reference Guide

Presumptive Definitive Reportable Drug Additional Reportable Drug/ Drug/Drug Class Examples of Generic/Trade/Street Name Urine Detection Timea Cutoff (ng/mL) Cutoff (ng/mL) or Metabolite Metabolitea

500 Ethyl Glucuronide (EtG) Ethyl Sulfate (EtS) Alcohol Metabolites 500 Up to 80 Hours 100 Ethyl Sulfate (EtS) Ethyl Glucuronide (EtG)

Amphetamine Amphetamine — Adderall®, Dexedrine®, Dextrostat®, Vyvanse® Amphetamines 500 250 Methamphetamine — Desoxyn® 1–3 Days Methamphetamine Amphetamine Benzphetamine — Didrex®

Amphetamine Amphetamine — Adderall®, Dexedrine®, Dextrostat®, Vyvanse® 250 Methamphetamine — Desoxyn® Methamphetamine Amphetamine Amphetamines Benzphetamine metabolite — Didrex® with Reflex 500 d-Methamphetamine — Desoxyn® 1–3 Days Methamphetamine d-Methamphetamine d/l Isomers Benzphetamine d-metabolite — Didrex® Selegiline l-metabolite — Eldepryl® l-Methamphetamine l-Methamphetamine —nasal inhaler

Amitriptyline Nortriptyline Amitriptyline — Elavil®, Endep® Amoxapine Amoxapine — Asendin®

Citalopram/Escitalopram Desmethylcitalopram Citalopram/Escitalopram — Celexa® (citalopram), Lexapro® Desmethylcitalopram (escitalopram) Clomipramine Desmethylclomipramine Clomipramine — Anafranil® Desmethylclomipramine Imipramine Imipramine — Tofranil® Desipramine Desipramine — Norpramin® Doxepin Desmethyldoxepin Antidepressantsc 10 10 Doxepin — Adapin® , Sinequan® 1–3 Days Desmethyldoxepin Duloxetine Duloxetine — Cymbalta® Fluoxetine Norfluoxetine Fluoxetine — Prozac® Norfluoxetine Fluvoxamine Norfluvoxamine Fluvoxamine — Luvox® Norfluvoxamine Hydroxybupropion Hydroxybupropion — Aplenzin® (bupropion) Imipramine Desipramine Imipramine — Tofranil® Maprotiline Maprotiline — Ludiomil®

a Depends upon drug usage patterns, drug/drug metabolite elimination, and test cutoff Note: Unless otherwise specified, the presumptive method of analysis is immunoassay. b Naloxone is reported when ordered c Presumptive analysis uses mass spectrometry method of analysis

Page 4 Clinical Drug Monitoring Reference Guide

Presumptive Definitive Reportable Drug Additional Reportable Drug/ Drug/Drug Class Examples of Generic/Trade/Street Name Urine Detection Timea Cutoff (ng/mL) Cutoff (ng/mL) or Metabolite Metabolitea

Mirtazapine Mirtazapine — Remeron® Amitriptyline Amitriptyline — Elavil®, Endep® Nortriptyline Nortriptyline — Aventyl® 10 10 Paroxetine Paroxetine — Paxil®, Seroxat® Protriptyline Protriptyline — Vivactil® Sertraline Norsertraline Sertraline — Zoloft® 50 50 Norsertraline Antidepressantsc 1–3 Days Trazodone 1-(3-Chlorophenyl)piperazine Trazodone — Desyrel® 1-(3-Chlorophenyl)piperazine Trimipramine Trimipramine — Surmontil®

10 10 Venlafaxine O-desmethylvenlafaxine Venlafaxine — Effexor® XR (venlafaxine), Khedezla O-desmethylvenlafaxine (desvenlafaxine) Vilazodone Vilazodone — Viibryd® Vortioxetine Vortioxetine — Trintellix®

2 Aripiprazole Dehydroxyaripiprazole 2 Aripiprazole — Abilify® 10 Dehydroxyaripiprazole 5 5 Brexpiprazole Brexpiprazole — Rexulti® 5 5 Cariprazine Cariprazine — Vraylar® Chlorpromazine 7-OH-chlorpromazine 10 10 Chlorpromazine — Largactil, Thorazine® 7-OH-chlorpromazine Clozapine Norclozapine 25 25 Clozapine — Clozaril® Norclozapine Fluphenazine 7-OH-fluphenazine Antipsychoticsc 5 5 Fluphenazine — Prolixin®, Modecate 1–3 Days 7-OH-fluphenazine 1 1 Haloperidol Haloperidol — Haldol® Loxapine 8-hydroxyloxapine 5 5 Loxapine — Loxapac, Loxitane® 8-hydroxyloxapine 5 5 Lurasidone Lurasidone — Latuda® 10 10 Mesoridazine Mesoridazine — Serentil® 5 5 Molindone Molindone — Moban® Olanzapine Desmethylolanzapine 2.5 2.5 Olanzapine — Zyprexa® Desmethylolanzapine

a Depends upon drug usage patterns, drug/drug metabolite elimination, and test cutoff Note: Unless otherwise specified, the presumptive method of analysis is immunoassay. b Naloxone is reported when ordered c Presumptive analysis uses mass spectrometry method of analysis

Page 5 Clinical Drug Monitoring Reference Guide

Presumptive Definitive Reportable Drug Additional Reportable Drug/ Drug/Drug Class Examples of Generic/Trade/Street Name Urine Detection Timea Cutoff (ng/mL) Cutoff (ng/mL) or Metabolite Metabolitea Quetiapine Norquetiapine 10 10 Quetiapine — Seroquel® Norquetiapine Risperidone OH-risperidone 5 5 Risperidone — Risperdal® OH-risperidone Antipsychotics 1–3 Days 50 50 Thioridazine Thioridazine — Mellaril®, Melleril Thiothixene Thiothixene — Navane® 5 5 Trifluoperazine Trifluoperazine — Stelazine® Ziprasidone Ziprasidone — Geodon®, Zeldox

Amobarbital — Amytal®, Amobarbital Secobarbital Amobarbital/Secobarbital Combination — Tuinal® Butalbital Butalbital — Esgic®, Fioricet®, Fiorinal®, Sandoptal® 1–3 Days Barbiturates 300 100 Pentobarbital Pentobarbital — Nembutal® Short-Acting; >3 Long-Acting Phenobarbital Phenobarbital — Luminal® Secobarbital — Seconal® Secobarbital Amobarbital Amobarbital/Secobarbital Combination — Tuinal®

25 Alpha-hydroxyalprazolam Alprazolam — Xanax® Alpha-hydroxymidazolam Midazolam — Versed® 50 Alpha-hydroxytriazolam Triazolam — Halcion® 25 Aminoclonazepam Clonazepam — Klonopin® Hydroxyethylflurazepam Flurazepam — Dalmane® Lorazepam Lorazepam — Ativan® Chlordiazepoxide — Librium® Oxazepam 1–3 Days Benzodiazepines 100 Nordiazepam Clorazepate — Tranxene® Short-Acting; >3 Long-Acting Oxazepam, Temazepam Diazepam — Valium® 50 Oxazepam — Librax®, Serax® Clorazepate — Tranxene® Oxazepam Nordiazepam Chlordiazepoxide — Librium® Nordiazepam, Temazepam Diazepam — Valium® Oxazepam Temazepam — Restoril® Temazepam Oxazepam, Nordiazepam Diazepam — Valium®

a Depends upon drug usage patterns, drug/drug metabolite elimination, and test cutoff Note: Unless otherwise specified, the presumptive method of analysis is immunoassay. b Naloxone is reported when ordered c Presumptive analysis uses mass spectrometry method of analysis

Page 6 Clinical Drug Monitoring Reference Guide

Presumptive Definitive Reportable Drug Additional Reportable Drug/ Drug/Drug Class Examples of Generic/Trade/Street Name Urine Detection Timea Cutoff (ng/mL) Cutoff (ng/mL) or Metabolite Metabolitea

Buprenorphine/Naloxone Combinationb — Bunavil®, Suboxone®, Norbuprenorphine, Naloxone ® Buprenorphine Zubsolv Norbuprenorphine Buprenorphine 5 2 Buprenorphine — Buprenex®, Butrans®, Subutex® 1–3 Days Norbuprenorphine Buprenorphine, Buprenorphine/Naloxone Combinationb — Bunavil®, Suboxone®, Naloxoneb Norbuprenorphine Zubsolv®

Carisoprodol Carisoprodol — Soma®, Equagesic® 1000 Meprobamate 1–3 Days Metabolite Meprobamate — Milltown®, Equanil®

Cocaine Metabolite 150 100 Benzoylecgonine Cocaine — Coke 1–3 Days

Eszopiclone 5 Eszopiclone Eszopiclone — Lunesta® 1–3 Days

Fentanyl Norfentanyl Fentanyl 0.5 0.5 Fentanyl — Abstral®, Actiq®, Duragesic®, Fentora®, Lonsys® 1–2 Days Norfentanyl

Gabapentin 1000 Gabapentin Gabapentin — Fanatrex, Gabarone, Neurontin® 1–3 Days

Heroin Metabolite 10 10 6-Acetylmorphine Heroin — Heroin 1 Day

Marijuana Dronabinol — dronabinol, Marinol® 1–3 Days Casual Use; 20 5 Marijuana Metabolite Metabolite Marijuana — pot, weed >3 Days Chronic Use

MDMA MDA Ecstasy MDMA/MDA 500 200 1-2 Days MDA Sally

Meperidine Normeperidine Meperidine 100/100 Meperidine — Demerol® 1-3 Days Normeperidine

Methadone Methadone EDDP 100 100 Methadone — Dolophine® 1–3 Days Metabolite EDDP

Methylphenidate 100 Ritalinic Acid Methylphenidate — Ritalin®, Concerta® 1–3 Days

Mitragynine 50 2 Mitragynine Kratom 1–3 Days a Depends upon drug usage patterns, drug/drug metabolite elimination, and test cutoff Note: Unless otherwise specified, the presumptive method of analysis is immunoassay. b Naloxone is reported when ordered c Presumptive analysis uses mass spectrometry method of analysis

Page 7 Clinical Drug Monitoring Reference Guide

Presumptive Definitive Reportable Drug Additional Reportable Drug/ Drug/Drug Class Examples of Generic/Trade/Street Name Urine Detection Timea Cutoff (ng/mL) Cutoff (ng/mL) or Metabolite Metabolitea

Naltrexone 6-beta-naltrexol Naltrexone 5 Naltrexone — ReVia®, Vivitrol® 1–3 Days 6-beta-naltrexol

Codeine — Tylenol® #3, Tylenol® #4, Tylenol® w/Codeine, Acetaminophen w/Codeine, Phenaphen® w/Codeine, Phenergan® Morphine w/Codeine, Phenameth w/Codeine, Promethazine w/Codeine Codeine Poppy seed ingestion

Hydrocodone Codeine minor metabolite Morphine — Avinza®, Kadian®, MS Contin®, Roxanol®; Heroin Codeine — Tylenol® #3, Tylenol® #4, Tylenol® w/Codeine, Acetaminophen w/Codeine, Phenaphen® w/Codeine, Phenergan® Codeine w/Codeine, Phenameth w/Codeine, Promethazine w/Codeine Morphine Poppy seed ingestion Opiates 100 50 1–3 Days Hydromorphone Morphine minor metabolite Heroin Metabolite Heroin metabolite Hydromorphone, Hydrocodone — Hycodan®, Lorcet®, Lortab®, Norco®, Vicodin® Hydrocodone Norhydrocodone Codeine, Morphine Codeine minor metabolite Hydromorphine — Dilaudid® Hydromorphone Hydrocodone, Norhydrocodone Hydrocodone — Hycodan®, Lorcet®, Lortab®, Norco®, Vicodin® Morphine Morphine minor metabolite Norhydrocodone Hydrocodone, Hydromorphone Hydrocodone — Hycodan®, Lorcet®, Lortab®, Norco®, Vicodin®

Noroxycodone Oxycodone, Oxymorphone Oxycodone — Endocet®, Magnacet®, OxyContin®, OxyFAST®, Oxycodone Noroxycodone, Oxymorphone OxyIR®, Percocet®, Percodan®, Perolox®, Roxicet®, Roxicodone®, Oxycodone 100 50 Tylox® 1–3 Days Oxycodone, Noroxycodone Oxymorphone Oxymorphone — Opana®, Numorphan®

Phencyclidine 25 25 Phencyclidine Phencyclidine — PCP 1–3 Days

Pregabalin 1000 Pregabalin Pregabalin — Lyrica® 1–3 Days

Propoxyphene 300 200 Norpropoxyphene Propoxyphene — Darvon®, Davocet®, Dolene®, Progesic®, Trycet® 1–3 Days

a Depends upon drug usage patterns, drug/drug metabolite elimination, and test cutoff Note: Unless otherwise specified, the presumptive method of analysis is immunoassay. b Naloxone is reported when ordered c Presumptive analysis uses mass spectrometry method of analysis

Page 8 Clinical Drug Monitoring Reference Guide

Presumptive Definitive Reportable Drug Additional Reportable Drug/ Drug/Drug Class Examples of Generic/Trade/Street Name Urine Detection Timea Cutoff (ng/mL) Cutoff (ng/mL) or Metabolite Metabolitea

AB-CHMINACA M2 AB-CHMINACA AB-FUBINACA M2 AB-FUBINACA N-pentanoic acid 2 2 AB-PINACA AB-PINACA ADBICA N-pentanoic acid ADBICA ADB-PINACA ADB-PINACA N-pentanoic acid

Synthetic 0.2 0.2 AKB48 N-pentanoic acid AKB48 K2, Spice, Bliss, Blaze c 1–3 Days Cannabinoids 2 2 BB-22 3-carboxyindole BB-22 JWH-018 N-pentanoic acid JWH-018 0.2 0.2 JWH-073 N-butanoic acid JWH-073

2 2 PB-22 3-carboxyindole PB-22

0.2 0.2 UR-144 N-pentanoic acid UR-144 5-Fluoro-PB-22 2 2 5-Fluoro-PB-22 3-carboxyindole

Butylone Butylone — Bk-MBDB MDPV — Bath salts, Ivory Wave, MDPV Synthetic 50 Vanilla Sky 1–3 Days Stimulants Mephedrone — 4-MMC, Meow Mephedrone Meow, M-CAT, Bounce Methylone Methylone — Bath salts

Tapentadol Nortapentadol Tapentadol 50 Tapentadol — Nucynta® 1–3 Days Nortapentadol

Tramadol Desmethyltramadol Tramadol 100 Tramadol — Rybix®, Ryzolt®, Ultram® 1–3 Days Desmethyltramadol

® ® Tricyclic Amitriptyline Nortriptyline Amitriptyline — Elavil , Endep 100 1–3 Days Antidepressants Nortriptyline Nortriptyline — Aventyl®, Pamelor®

Zolpidem Zolpidem Metabolite Zolpidem 5 Zolpidem — Ambien®, Edluar®, Intermezzo®, Zolpimist® 1–3 Days Zolpidem Metabolite

a Depends upon drug usage patterns, drug/drug metabolite elimination, and test cutoff Note: Unless otherwise specified, the presumptive method of analysis is immunoassay. b Naloxone is reported when ordered c Presumptive analysis uses mass spectrometry method of analysis

Page 9

Clinical Drug Monitoring: Tests and Services

Healthcare providers have trusted Quest Diagnostics for clinical drug monitoring for years. Our reputation in clinical laboratory diagnostics is built on an unparalleled commitment to service, coupled with one of the industry’s most comprehensive drug testing menus.

You can rely on us for: •  A broad menu, including prescription drug medications, other •  Easy-to-read clinician and patient result reports controlled medications, illicit drugs, and designer drugs •  Quarterly Report to compare medMATCH® rates of your practice to the •  Enhanced sensitivity to better detect benzodiazepines and opioids Quest Diagnostics national database •  Toxicology experts to help with results interpretation and consultation

We’re committed to working with you to provide objective results and insight to support your clinical decisions.

Drug monitoring consultation Our experts are available to assist with:

•  Drug monitoring menu, options, and services—discuss test selection, sample requirements, and whether or not to choose medMATCH® • Drug monitoring results inquiries and interpretation—discuss basic result interpretations and questions about adding additional substances to the test • Drug monitoring consultation scheduling—schedule a call with appropriate experts on more complex questions

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