Unrecognized Spatial Disorientation Recognition: A Methodological Study

Rucha P. Shankersinh Vaghela Bapu Group of Institutions, Gandhinagar, India

ABSTRACT the body balanced in a complex, ever-changing world. In terms of the triggers of SD, researchers have agreed that Pilots also experience spatial disorientation (SD) when flying. visual illusions in the three-dimensional space motion world One factor contributing to this issue is the lack of a validated are at the root of the condition. procedure for detecting Type I (unrecognized) SD. Most of the current literature focuses on recognized SD evaluation Under normal conditions, humans gather knowledge (via the methods, but there are few reports that concentrate on sensory system, , and system unrecognized SD evaluation methods. We go through some of [7]) to assess their orientation and condition. The visual the issues with SD and compare the various SD assessment system is responsible for around 80% of the details required approaches. We report on the benefits and drawbacks of the for orientation [9]. The vestibular mechanism, which includes quantitative questionnaire assessment process and the the semicircular canal organ and the otolith organ, is situated behavior evaluation method in these books. We suggest a tool in the inner part of the ear and provides information for to diagnose unrecognized SD based on these analyses, which positioning [10]. Linear acceleration and gravity variations are improves SD estimation in many ways. Centered on the sensed by otolith lungs, while angular acceleration changes subjective report and the core of strain, we establish a new are sensed by [11]. In the processing of approach to studying unrecognized SD (CoP). This latest extra stimulation, the proprioceptive organ performs a approach compensates for the lack of unrecognized SD supportive function. It can detect the location of the limbs. identification. We will help the pilots appreciate their Muscle and tendon receptors react to shifts in muscle duration emotions and physical adjustments as they are subjected to and stress, while skin receptors sense the body's atmosphere unrecognized SD by using the latest appraisal process. This [10]. The human brain must interpret all the knowledge assessment approach is hoped to provide good encouragement presented by these three structures before recognizing the for unrecognized SD countermeasures and profoundly right location [12]. The brain can encounter sensory overcome the serious flight injuries induced by unrecognized interference if some device receives inappropriate or wrong SD. input [13]. SD is triggered by a conflict in knowledge given by these programs [14]. Often SD cases are caused by visual and vestibular causes. In visual orientation and awareness of the surrounding world, vision is critical. Visual stimuli will Keywords easily contribute to erroneous perceptions of the world, such Aerospace medicine, spatial disorientation, evaluation as the self-rotation illusion (also known as vection [15]). It's method, cognition, postural sway. affected by a flowing visual scene that causes the pilot to misjudge his plane's height [10]. The vestibular system and the proprioception system are severely limited since the 1. INTRODUCTION human body exists in a three-dimensional space world. The Pilots often experience spatial disorientation (SD) when flying vestibular organ is unable to detect the steady motion [1]. SD poses a significant challenge to flight safety and has condition correctly. When the human body is tilted at a slight an effect on it [2]. SD is characterized by Gillingham [3] as a angle for an extended period, tilt illusion or somatotropic misperception of stance, height, and motion in relation to the illusion may occur [2]. When SD strikes, it causes a slew of ground plane (narrow definition). The pilot's misperception of symptoms [10]. Observers also recorded nausea, salivation, the vertical line of gravity and misjudgment of his flight light-headedness, , queasiness, cold sweats, moderate attitude compared to other aircraft (general description) are restlessness, , and behavioral disorders as signs of pain. then applied to the definition [4]. SD is a form of situational These signs and effects resemble those of awareness failure [5]. People's right cognition of the (MS). While the exact function of MS remains unknown, surrounding world, including location, direction, temperature, most experts believe that it involves sensory disputes. Some self-control capacity, and so on, is referred to as situational researchers believe that SD is the source of MS. In terms of awareness [6]. When spatial memory is lost, SD exists [7]. pathways and clinical signs, SD and MS are strikingly close. As a result, certain MS references are used in this research. Researchers have been studying human spatial orientation in Form I (unrecognized SD), Type II (recognized SD), and detail for a long time. The brain's understanding of the body's Type III (incapacitating SD) are the three forms of SD [10]. location and rotation in relation to the ground is known as The pilot does not experience any pain and does not believe spatial orientation. The spatial information from each sensory the plane is in an unnatural condition when unrecognized SD receptor is processed to form this experience. Its job is to keep occurs. To put it another way, as unrecognized SD happens,

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pilots undergo unrecognized spatial disorientation and are countermeasure of unrecognized SD, and to radically address unaware of it. Spatial disorientation is now believed to arise the serious flight injuries triggered by unrecognized SD. when the pilot does not have adequate visual stimulation to alert him or her to a concern whilst flying. The effects of this 2. Spatial disorientation Assessment form of SD are often serious. Most of the type I SDs result in In SD analysis, an analytical, scientific, and accurate SD managed flight into terrain (CFIT). Even though unrecognized assessment approach is urgently needed to analyze the process SD is responsible for multiple significant incidents, there is a of SD and implement appropriate SD countermeasures. paucity of studies because unrecognized SD is below the Scholars have assessed SD using one or more assessment cognitive level. SD type II is a recognized type of tools. Subjective questionnaires, behavioral methods (eye- misperception in which pilots make incorrect decisions movements [17], flight success [18], posture reaction [19]), regarding flight attitude, direction, and motion. They often neurocognitive methods (electrogastrogram (EEG)) [40], and have contradictions with the physical space state and the psychophysiological methods [41] are among the assessment optical space state of the instrument. Fortunately, pilots are methods. Electrogastrography (EGG) [22], instantly mindful of these issues [4]. Incapacitating SD, form electrocardiography (ECG), heart rate (HR), blood pressure III, is a psychiatric disorder in which pilots have misjudged (BP), respiratory rate, and tidal volume [23], flight mood, location, and motion state and are mindful of electromyography (EMG) [31], electrooculogram (EOG) [25], their mistakes [13]. The operator, on the other hand, is skin electrical activity [16], and salivary cortisol amount [17] psychologically ill and unable to properly fly the plane [8]. are several of the physiological measurements. Questionnaires The effects of this kind of SD are severe [13]. Scholars have for assessing shifts in stress, subjective physical, and recently agreed that the three forms of SD are part of a psychical state, reconstruction interviews, mission reaction continuous continuum. Because of the various cognitive levels time, and consistency are among the psychological evidence in the brain, they are classified into three categories [7]. Even [18]. Subjective questionnaires and posture balance research though SD study has been ongoing for over 40 years, it are the emphasis of this review. From the two assessment continues to have a significant impact on flight safety. SD has techniques, we aim to derive an objective and logical been linked to 54 percent of flight crashes in the last ten years. identification approach appropriate for unrecognized SD. In a A Class crash happens once per million flight hours on separate article, other assessment approaches (EEG signal average. SD's crash incidence is that in tandem with the analysis, physiological parameter identification, psychological increase in aircraft speed. Unrecognized SD is responsible for parameter analysis, eye activity monitoring, flight phenotype, 80-85 percent of all SD deaths. A good percentage of them are cognitive task completion stage, and so on) would be already deadly injuries. Many academic organizations have evaluated and addressed. investigated the SD process, SD measurements, SD countermeasures, and pilot preparation to prevent SD. While 3. Questionnaire evaluation these branches have made significant progress [1, 29], there Of all the detection approaches used in the SD analysis, the are still several issues to be addressed. By comparing subjective questionnaire was the first. This technique is European aviation accident statistics from 1983 to 1992 to critical for detecting and assessing SD. Most of the current 1993 to 2002, it's easy to see that, while the overall accident research has evaluated SD using one or more questionnaires. rate has declined from 4.17 to 2.70 per million flight hours, Direct questions (questions regarding role judgment and the proportion of injuries induced by SD has risen from 24.7 physical state) [19] [25][11], questions about SD-related to 33.0 percent. Both figures suggest that the amount of flight symptoms (vertigo, dizziness, and nausea, for example) [12], injuries induced by SD is not decreasing. One cause of this and a dynamic scale questionnaire [13] are used to validate issue is the lack of a validated tool for objectively measuring the degree and grade of SD. The questionnaire approach SD. To screen pilots' vulnerability to SD, none of the pilots' encompasses most subjective assessment techniques. The selection parameters have been used. Furthermore, the most questionnaires cover the SD procedure, the situation at the critical point is that most of the existing research are based on time, the real flight situation, the pilot's physical health, and recognized SD (type II). Just a few reports have focused on his or her feelings [14][12]. Now, several studies on SD have unidentified SD, which is responsible for most serious flight evaluated it using subjective questions or questionnaires. crashes. The countermeasures in preparation would not succeed if pilots may not know that they have encountered 3.1 Motion Sickness Questionnaire (MSQ) unrecognized SD. As a result, a reliable approach for In the 1960s, the Pensacola motion sickness questionnaire detecting undiagnosed SD is needed. Countermeasures against (MSQ) was developed to assess the orientation issue [15, 16]. unrecognized SD may be applied if it is identified. To prevent MSQ was developed using Alexander et al [17]. scoring and counteract unrecognized (Type I) SD impacts, targeted system. Since the 1980s, the MSQ has been commonly used countermeasures are also needed. to investigate the issue of orientation and multiple sclerosis. As a result, we summarize the current SD assessment Later that year, in 2001, the motion sickness screening approaches in this article. We concentrate on the benefits and questionnaire (MSAQ) was revised and processed to include drawbacks of subjective measurement and behavior methods the MSQ. The MSAQ was developed by Gianaros et al. [28] within these methods. Then, we present a new approach for detecting unrecognized SD that, for the first time, identifies to treat motion sickness. Their findings indicate that the unrecognized SD below the cognitive threshold. It MSAQ is an effective instrument for assessing motion compensates for the lack of unrecognized SD identification. sickness, and that it may be used to measure motion sickness We will also help the pilots appreciate their emotions and from a variety of viewpoints. The motion sickness sensitivity physical adjustments as they are subjected to unrecognized questionnaire (MSSQ) is another questionnaire that assesses SD using the latest appraisal process. This assessment MS induced by mild environmental stimulus [12]. Since MSQ approach is hoped to provide good encouragement for the is ineffective for moderate alignment issues and temporary

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vertigo, several researchers developed MSSQ. The authors encounter. As a result, although this form of assessment is suggested in 2017 that the MSSQ-short be used to assess MS beneficial, it is not impartial. resistance to moderate symptoms such as visually evoked vection [10]. Vection is often referred to as the illusion of 3.4 Analysis and Synthesis relative motion [11]. When participants see the revolving SD usually presents with signs close to motion sickness and scene, they will believe that their own bodies are still rotating simulator sickness [14]. According to most researchers, SD, [62]. This is a standard SD occurrence. simulator nausea, and MS are both classified as orientation conditions, which overlap [7]. As a result, it is fair to assess 3.2 Simulator Sickness Questionnaire SD using the MSQ or SSQ. The questionnaire results make it (SSQ) simple to understand pilots' status, especially their in-flight MSQ has been commonly used to research the issue of MS preparation. As a result, this form of assessment is commonly and SD since the 1980s. Several researchers started utilized in the analysis of SD. developing questionnaires to assess SD and simulator illness (SS). As previously mentioned, SS, SD, and MS are While this strategy is advantageous, it may have certain inextricably linked [23]. Kennedy et al. [24] evaluated drawbacks. Typically, participants complete the questionnaire simulator-induced SD using SSQ in 1997. Other researchers prior to or after the experiment. As a result, it is not timely also used the SSQ to assess simulator sickness in follow-up and does not accurately reflect the participants' feelings while trials [14, 15]. Along with studying simulator nausea, other they are undergoing SD. As a result, the subjective aspect is researchers used SSQ to investigate the impact of SD toxicity substantial, and it differs significantly between pilots. during virtual flight [16, 17]. Their findings revealed that the Additionally, it is difficult to obtain a clear flight atmosphere implementation of the SSQ may offer support for the and flight sensations for SD. As a result, some experiments diagnosis of SD. However, the current issues remain quite use the subjective answer to SD rather than asking too many visible. This questionnaire is not intended to assess SD and questions or interfering with the experiment [72]. therefore cannot be used in place of the SSQ questionnaire. Additionally, the current questionnaire approach is contingent upon pilots having encountered and understood SD. 3.3 Questionnaire on Spatial Subjective inquiry findings with no SD are listed in these Disorientation analyses as no incident of SD. Unrecognized SD, on the other Several scholars created a specific questionnaire for SD hand, can occur even if there is no subjective feeling of SD, during the implementation of the SSQ. Durnford et al. [68] according to the SD classification. The questionnaire form conducted an SD questionnaire in a 1996 US Army rotary cannot be used to identify unrecognized SD. As a result, this study. This questionnaire differs in content from others. This form of assessment is effective in Type II (recognized SD) questionnaire is designed to elicit information about the and Type III (incapacitating SD). However, it is incapable of occurrence of SD episodes, the forms of SD, their definition, providing an adequate assessment of unrecognized SD. and classification. Mild disorientation, serious disorientation, and extreme disorientation were all included in the 4. Behavior Data Evaluation questionnaire. The findings confirmed that younger pilots are The analysis of human reactions to stimuli in both internal and more vulnerable to SD than older pilots, suggesting that this external contexts is referred to as ethology. The sensory questionnaire is an important tool for assessing SD. Wang et system, vestibular system, and proprioceptive system of the al. and Sharon Holmes et al. [9] also record similar findings. human body detect and relay external stimulation to the brain, They discovered a statistically important discrepancy in the which directs the body to react appropriately. Numerous scale's score between individuals with and without SD flight experiments have shown that as pilots develop SD, their experience. Following that, Stephens [7] conducted a report cognitive capacity and flight efficiency deteriorate on SD using a quantitative questionnaire, verifying that a dramatically [15]. Additionally, the behavior of postural sway questionnaire should be used to test SD. Some researchers, is strongly associated with the frequency of SD. Subjective such as Subtil et al. [7], have examined vertigo in conjunction considerations have little effect on the data pertaining to with visual disorientation. They spoke about the flight's human postural sway, and the scale of the body migration particular atmosphere as well as the severity and extent of may also represent the intensity of the directional capacity. vertigo. Christine M. et al. [4] refined the classification and Thus, postural sway study is also used in the medical sector. severity of vertigo based on previous research. They The behavioral assessment approach is critical in developing established the validity of the subjective questionnaire countermeasures against SD, since it assesses the correctness approach for assessing SD. Helena et al. published the most and effectiveness of service [6] as well as the behavioral recent report in 2020 [11]. They created a comprehensive SD features associated with the flight illusion (eye movement [7], assessment questionnaire to determine the effectiveness of SD head movement [2], body sway [7], etc.). External input from preparation. Their findings indicate that this SD questionnaire the perceptual, vestibular, and proprioceptive processes may be used to assess the effectiveness of teaching. However, primarily determines human equilibrium and posture [18]. In the questionnaire is performed after the conclusion of the SD general, the postural reaction is synchronized with the visual

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environment. Spatial disorientation may arise when visual and dysfunction is a sign of multiple sclerosis. Several authors vestibular or proprioceptive knowledge clash [19], resulting in concur with this opinion [9, 10]. The stability of a participant's postural instability [8]. Sensory conflict arises, for example, body seems to predict whether they will suffer visually while the body is still and observing a two-dimensional or triggered motion sickness (VIMS) or not. Rafael Labissiere et three-dimensional action sensation. While visual feedback is al. examined the association between resistance to multiple dynamic, vestibular input is static. SD is believed to be the sclerosis and posture flexibility. The finding indicates that product of this disagreement [11]. As SD happens, participants with a history of multiple sclerosis exhibited a participants exhibit an involuntary body tilt. Full vestibular greater number of high-frequency components in the visual information is needed for orientation in this situation. As a flow scene. Regarding visually triggered MS, subjects with a result, it is important to balance the head and strengthen background of MS demonstrated a greater number of postural vestibular feedback to maintain proper posture [9]. swings in the low-frequency signal. Because of the findings, it is concluded that participants' individual power spectral 4.1 Regulation of Posture in Vection density (PSD) can be used to estimate MS levels. In 2017, Vection is a type of SD [9], which is associated with MS Hwang et al. [6] estimated each participant's postural sway indirectly through posture behavior. Previously, the before and after the stimulus onset using the visually triggered relationship between postural sway and vection was defined relative motion illusion. The findings indicate that postural [82]. Almost all researchers in posture management use visual sway may be used to differentiate visually caused motion imagery as their experimental stimuli. Since 2002, many sickness (VIMS) from non-VIMS. Lubeck et al. [11] experiments on postural sway have used force platforms to concluded that VIMS significantly increases all postural gather data on shifts in the center of pressure (CoP) during the swing parameters (swing path length, standard deviations in experiment [3, 4]. They assume that there are major variations all directions, and short-term scaling components). In 3D, in the coefficient of friction between vection and non-vection. there was no noticeable change in postural sway relative to Thurrell et al. [4] explored whether conscious awareness of 2D. Kim induced MS using augmented reality technologies. self-motion has an impact on the extent of visually mediated The SSQ and posture monitoring were used to assess postural responses. They concluded that in vection, the CoP participants' degree of disorientation in their study. The offset was greater than in non-vection. Additionally, the findings indicate that various visual scenes caused varying findings indicated that the visually mediated postural reaction degrees of MS. Additionally, the less motion sickness varies in response to various visual stimuli. In a related participants registered, the more relaxed their posture control, research published in 2005, Fushiki et al. [3] analyzed the and vice versa. According to their findings, the more extreme deviation of the head and body during the procedure using a the participants' SD, the more challenging it was for them to video-motion-analysis system. They concluded that when the maintain postural equilibrium. illusion of relative motion was created, posture equilibrium was altered. Then, in 2015, Da-Silva et al. [5] used a complex 4.3 Analysis and Synthesis simulated stimulation system to induce vection and studied Postural sway is sometimes used as an objective indicator of CoP results from participants seeing visual scenes at varying vection. Visually mediated postural sway is not often illusory speeds and directions. The findings indicate that when the [5, 6]. Additionally, the magnitude of visually mediated human body's pose equilibrium is disrupted by relative motion postural sway has risen in lockstep with the rise of visual illusion, the plantar pressure core tends to shift. When scene movement. According to Kuno et al. , visually mediated subjected to optical flow stimulus, increasing evidence postural sway increased vection. Much more recently, indicates that variations in postural instability will predict research has shown that postural instability will accurately vection and SD [2, 6]. Observing a shifting field of view, predict vection. The above findings demonstrate a strong without a doubt, may trigger disorientation [7], which can correlation between postural sway and the prevalence of SD. manifest itself in postural changes. However, in certain In medicine, the posture equilibrium is sometimes used to visually mediated SD settings, the variations in postural sway assess if an individual's orientational function is natural. are often insignificant enough to jeopardize equilibrium []. Postural sway data are quantitative and unaffected by This suggests that when subjects are exposed to a bad contextual considerations. Additionally, the degree of postural stimulus or a purely visual stimulus, their posture sway can be sway is indicative of orientational strength. Numerous slight, and they may be unaware of the vection. Unrecognized experiments have shown that when subjects are subjected to SD is the most serious hazard to flight safety. As a result, SD, their head or trunk begins to sway, which then results in even pilots are unaware of SD. It is also possible to discover the sway in CoP. This sway will occur in two ways: 1) issues because of their postural sway. subjects believe there is no sway in their body, or 2) subjects report feeling a sway in their body. In the first instance, this 4.2 Posture Regulation of Multiple disorder occurs below the cognitive level and is classified as Sclerosis an unrecognized SD. In the second instance, this disorder Along with the study of postural sway in the presence of exceeds the neurological level and is therefore classified as a vection, some researchers use postural stability to assess MS recognized SD. As a result, behavioral screening may be used susceptibility. Gary E. and Thomas A. claim that postural to assess both unrecognized and known SD.

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5. THE EVALUATION OF the CoP is measured. The RMS value indicates the dispersion UNRECOGNIZED SD of the CoP. A framework for evaluating unrecognized SD is proposed If the root mean square error of the CoP exceeds the highest based on the interpretation and description of the above confidence interval in visual flow experiments, it is research. This assessment technique is referred to as the determined that the swaying postures have a statistically contextual report of postural sway (SRPS). This form of meaningful variance. This variance is attributed to SD in this assessment was previously tested in our study and was shown situation. In the other hand, whether the RMSE value is to be feasible. It is anticipated that this form of evaluating smaller than or equal to the confidence interval's maximal undiagnosed SD would have good encouragement for pilot value, it is determined that there is no statistically meaningful screening and the countermeasure for undiagnosed SD. variation in the swaying postures. Participants in this situation Finally, profoundly resolving the serious flight crashes should not undergo SD. triggered by unrecognized SD. The drawbacks and details of this assessment process are discussed in depth here. This In general, if the root mean square error (RMSE) was on the assessment technique blends subjective reports with CoP correct side of the confidence interval, the CoP results for this evidence to identify previously unrecognized SD. Participants test is substantially different from the control group subject to the visual flow must maintain as much silence as (represented by +). If the RMS value is on the left side of the practicable. In this situation, the vestibular and proprioceptive confidence interval, there is no substantial gap between the receptors provide static information, while the visual receptors experimental and control groups (represented by -). provide motion information. Then sensory conflict develops, and certain participants develop SD, resulting in postural 6. Discussion sway. The CoP evidence and the participants' subjective SD has a major impact on air control. Although several reports (whether they perceive SD) are collected in the tests. researchers have been concerned with and researched SD, there is a dearth of specific research on unrecognized SD (a 5.1 Self-Report type of SD that leads to serious flight accidents). The reason This identification focuses on unrecognized SD, which the for this is that unrecognized SD is associated with the participants are unaware of. Thus, at the conclusion of each subconscious, which is below the threshold of cognition. Due experiment, participants must indicate whether they to a shortage of reliable methods for evaluating unrecognized encountered SD. SD is described here as the sensation of the SD, the injuries triggered by unrecognized SD cannot be body shifting or rotating. fundamentally resolved. To address the above issues, we summarize the current SD assessment methods. Among these The responses of the participants fell into two categories: approaches, we examine the subjective assessment approach 1. If the subject responds affirmatively to the question 'Yes, I and the behavior evaluation method for their relative merits am running or turning.', he has undergone recognized SD (the and demerits. Following that, we present a novel approach for illusion of relative motion). '+' is used to denote this case in detecting unrecognized SD. This method employs subjective this instance. responses in conjunction with the CoP oscillation to detect previously unrecognized SD. Through using this form of 2. If the subject responds, 'No, I am not jumping or turning,' study, scholars may ascertain if the pilot suffered from an he might have had an unrecognized SD or none '-' is used to unrecognized SD. denote this case in this instance. 6.1 Methods of Evaluation Discussion 5.2 Postural Instability (CoP Oscillation) Numerous researchers have dedicated their careers to assessing SD over the years. Additionally, many assessment techniques have been developed for SD, but none are accurate To determine if participants' CoP oscillations deviated greatly or uniform for unrecognized SD. when subjected to visual flow. It is important to establish a The conventional approach for subjective appraisal is a pre- regular range of CoP oscillations in the absence of visual and post-experiment questionnaire sample. The questionnaire flow. The control trials have the standard selection. Before assessment tool enables the pilot's flight status, flight any experiment, it is advised that each subject completes at expertise, and the presence of SD to be determined. It is least six supervised trials (no visual stimulus, balanced beneficial to determine the SD incident rate and the flight standing). The CoP results from these control trials was scene. His system, however, contains certain subjective measured to achieve a 95 percent confidence interval, which elements. The questionnaire takes a long time to complete, is used to define the standard range of CoP oscillations. and the pilots' status cannot be tracked in real time. As a As a subject is subjected to visual flow, the participant's CoP result, this assessment approach is applicable to accepted SD data is collected, and the root mean square error (RMSE) of that exceeds the cognitive level [32]. The behavioral appraisal is focused on quantitative measures such as eye monitoring

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and detection of body position balance. As subjects are comprehending the emotions and physical improvements subjected to SD, the CoP results dramatically sway. When a associated with unrecognized SD by using the latest appraisal person experiences SD, postural imbalance exists. As a result, process. It is anticipated that this appraisal approach would if participants' postural sway is important in the absence of a offer good encouragement for unrecognized SD subjective SD response, this state is classified as an countermeasures and would profoundly resolve serious flight unrecognized SD. Scholars will pay increased attention to injuries triggered by unrecognized SD. unrecognized SD studies as behavioral and cognitive assessment approaches continue to grow. 8. REFERENCES [1] Bowman, M., Debray, S. K., and Peterson, L. L. 1993. 6.2 The Subjective Report of Postural Reasoning about naming systems. 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Genomic [21] Shiff NJ, Oen K, Rabbani R, Lix LM. Validation of Profiling of Childhood Tumor Patient-Derived Xenograft administrative case ascertainment algorithms for chronic Models to Enable Rational Clinical Trial Design. Cell childhood arthritis in Manitoba, Canada. Rheumatol Int. Rep. 2019;29(6):1675-1689.e9. 2017;37(9):1575-1584. doi:10.1007/s00296-017-3734-1 doi:10.1016/j.celrep.2019.09.071 [22] Patel, R., Kunche, A., Mishra, N., Bhaiyat, Z., & Joshi, [35] Upton K, Modi A, Patel K, et al. Epigenomic profiling of P. R. (2015). Paytooth—a cashless mobile payment neuroblastoma cell lines. Sci Data. 2020;7(1):116. system based on Bluetooth. International Journal of Published 2020 Apr 14. doi:10.1038/s41597-020-0458-y Computer Applications, 120, 38– [36] Kendsersky NM, Lindsay J, Kolb EA, et al. The B7-H3- 43. https://doi.org/10.5120/21412-4450. Targeting Antibody-Drug Conjugate m276-SL-PBD Is [23] Buxton, E. K., Vohra, S., Guo, Y., Fogleman, A., & Potently Effective Against Pediatric Cancer Preclinical Patel, R. (2019). Pediatric population health analysis of Solid Tumor Models. Clin Cancer Res. southern and central Illinois region: A cross sectional 2021;27(10):2938-2946. doi:10.1158/1078-0432.CCR- retrospective study using association rule mining and 20-4221 multiple logistic regression. Computer methods and [37] vertical and subjective postural head vertical during programs in biomedicine, 178, 145–153. static roll-tilt. Laryngoscope Investigative [24] Wibirama S, Santosa PI, Widyarani P, Brilianto N, Otolaryngology. 2017; 2(3): 125-30.doi: 10.1002/lio2.72. Hafidh W. Physical discomfort and eye movements [38] Thilo KV, Kleinschmidt A, Gresty MA. Perception of during arbitrary and optical flow-like motions in stereo Self-Motion from peripheral optokinetic stimulation 3D contents. Virtual Real-London. 2020; 24(1) suppresses visual evoked responses to central stimuli. J [25] Tamura A, Wada Y, Shimizu N, Inui T, Shiotani A. Neurophysiol. 2003; 90(2): 723-30.doi: Correlation of climbing perception and eye movements 10.1152/jn.00880.2002. during daytime and nighttime takeoffs using a flight [39] Ledegang WD, Groen EL. Spatial Disorientation simulator. Acta Oto-Laryngol. 2016; 136(5): 433-8.doi: Influences on Pilots’ Visual Scanning and Flight 10.3109/00016489.2015.1132844. Performance. Aerosp Med Hum Perf. 2018; 89(10): 873- [26] Cowings PS, Toscano WB, Reschke MF, Tsehay A. 82.doi: 10.3357/AMHP.5109.2018. Psychophysiological assessment and correction of spatial [40] Patel, Rushabh. “Predicting Invasive Ductal Carcinoma disorientation during simulated Orion spacecraft re-entry. Using a Reinforcement Sample Learning Strategy Using Int J Psychophysiol. 2018; 131: 102-12.doi: Deep Learning.” ArXiv:2105.12564 [Cs, Eess], May 10.1016/j.ijpsycho.2018.03.001. 2021. arXiv.org, http://arxiv.org/abs/2105.12564.

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[41] Patel, Rushabh, and Yanhui Guo. “Graph Based Link Prediction between Human Phenotypes and Genes.” ArXiv:2105.11989 [Cs], May 2021. arXiv.org, http://arxiv.org/abs/2105.11989.

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