Secretagogin (SCGN) (1-276, His-Tag) Human Protein Product Data

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Secretagogin (SCGN) (1-276, His-Tag) Human Protein Product Data

OriGene Technologies, Inc. 9620 Medical Center Drive, Ste 200 Rockville, MD 20850, US Phone: +1-888-267-4436 [email protected] EU: [email protected] CN: [email protected] Product datasheet for AR09660PU-L Secretagogin (SCGN) (1-276, His-tag) Human Protein Product data: Product Type: Recombinant Proteins Description: Secretagogin (SCGN) (1-276, His-tag) human recombinant protein, 0.25 mg Species: Human Expression Host: E. coli Tag: His-tag Predicted MW: 34.2 kDa Concentration: lot specific Purity: >90% by SDS–PAGE Buffer: Presentation State: Purified State: Liquid purified protein Buffer System: 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 1mM DTT, 0.1M NaCl Preparation: Liquid purified protein Protein Description: Recombinant SCGN protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Storage: Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. Stability: Shelf life: one year from despatch. RefSeq: NP_008929 Locus ID: 10590 UniProt ID: O76038 Cytogenetics: 6p22.2 Synonyms: CALBL; DJ501N12.8; SECRET; SEGN; setagin Summary: The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in KCL- stimulated calcium flux and cell proliferation. [provided by RefSeq, Jul 2008] This product is to be used for laboratory only. Not for diagnostic or therapeutic use. View online » ©2021 OriGene Technologies, Inc., 9620 Medical Center Drive, Ste 200, Rockville, MD 20850, US 1 / 2 Secretagogin (SCGN) (1-276, His-tag) Human Protein – AR09660PU-L Product images: This product is to be used for laboratory only. Not for diagnostic or therapeutic use. ©2021 OriGene Technologies, Inc., 9620 Medical Center Drive, Ste 200, Rockville, MD 20850, US 2 / 2.

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Oup Cercor Bhx101 1..13 ++
Cerebral Cortex, 2017; 1–13 doi: 10.1093/cercor/bhx101 Original Article ORIGINAL ARTICLE Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity Chandrasekhar S. Raju1,2, Julien Spatazza1,2,7, Amelia Stanco3,8, Phillip Larimer4,5, Shawn F. Sorrells1,2, Kevin W. Kelley1,2, Cory R. Nicholas2,5,7, Mercedes F. Paredes2,5, Jan H. Lui2,5,9, Andrea R. Hasenstaub4,6, Arnold R. Kriegstein2,5, Arturo Alvarez-Buylla1,2, John L. Rubenstein3 and Michael C. Oldham1,2 1Department of Neurological Surgery, University of California, San Francisco, USA, 2The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, USA, 3Department of Psychiatry, University of California, San Francisco, USA, 4Center for Integrative Neuroscience, University of California, San Francisco, USA, 5Department of Neurology, University of California, San Francisco, USA, 6Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, USA, 7Present address: Neurona Therapeutics, South San Francisco, CA, USA, 8Present address: EntroGen, Woodland Hills, CA, USA and 9Present address: Howard Hughes Medical Institute and Department of Biology, Stanford University, Stanford, CA, USA Address correspondence to Michael C. Oldham. Email: [email protected] Abstract The neocortex of primates, including humans, contains more abundant and diverse inhibitory neurons compared with rodents, but the molecular foundations of these observations are unknown. Through integrative gene coexpression analysis, we determined a consensus transcriptional profile of GABAergic neurons in mid-gestation human neocortex. By comparing this profile to genes expressed in GABAergic neurons purified from neonatal mouse neocortex, we identified conserved and distinct aspects of gene expression in these cells between the species.
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