Weight Management As a Treatment Option for Gastroesophageal Reflux Disease: a Mechanical Or Metabolic Rescuer?
Gut and Liver, Vol. 12, No. 6, November 2018, pp. 607-608 Editorial Weight Management as a Treatment Option for Gastroesophageal Reflux Disease: A Mechanical or Metabolic Rescuer? Hyuk Lee Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea See “Weight Loss as a Nonpharmacologic Strategy for Erosive Esophagitis: A 5-Year Follow-up Study” by Ki Bae Bang, et al. on page 633, Vol. 12. No. 6, 2018 Gastroesophageal reflux disease (GERD) is a multifactorial fundamental cause of GERD symptom and therefore cannot disease with both anatomical and functional factors involved be improved with weight loss, and subjective evaluation of the in the pathogenesis. Although the basic understanding is symptoms that vary among different studies.4 Overall, studies that GERD is caused by increased relaxation of the transient that focus on a more objective and accurate index–which is lower esophageal sphincter accompanied by impaired lower endoscopic erosive esophagitis–and its association with weight esophageal sphincter basal tone or gastric or esophageal motor change are limited. dysfunction, the exact pathogenesis of GERD is still not fully In this issue of Gut and Liver, Bang and Park5 have pre- understood.1 In addition, environmental factors are considered sented an evidence for the association of BMI with endoscopic as important risk factors for GERD, more specifically, being erosive esophagitis in their retrospective cohort analysis of the overweight/obese, inappropriate dietary habits, lack of regular health checkup population. More specifically, improvement physical activity, and smoking.2 Nonetheless, whether or not the of erosive esophagitis was associated with reduced BMI, and improvements or changes in these lifestyle habits can lead to a adequate weight reduction was positively correlated with more protective beneficial effect against GERD remains unclear.
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