Debbie Sookman Is an Outstanding Contribution to the Science and Clinical Practice Related to the Full Range of Obsessive Com- Pulsive Disorder
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2019 Report to the Governor and General Assembly
2019 Report to the Governor and General Assembly Virginia Department of Health Report on the Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections and Pediatric Acute-onset Neuropsychiatric Syndrome Advisory Council PANDAS/PANS Advisory Council 2019 Report to the General Assembly Table of Contents Executive Summary 3 Background 4 PANDAS/PANS in Virginia 5 Status Report on PANDAS/PANS Advisory Council Activities 5 Summary and Future Plans 7 Recommendations 7 References 10 Appendix A – PANDAS/PANS Advisory Council and Subcommittee Members 11 Appendix B – November 26, 2018 Meeting Minutes 12 Appendix C – March 22, 2019 Subcommittee Meeting Minutes 17 Appendix D – March 25, 2019 Subcommittee Meeting Minutes 18 Appendix E – April 8, 2019 Meeting Minutes 20 Appendix F – May 20, 2019 Subcommittee Meeting Minutes 24 Appendix G – June 20, 2019 Meeting Minutes 25 Appendix H – September 23, 2019 Meeting Minutes 28 Appendix I – Suggestions for Marketing PANDAS/PANS Resources 31 Appendix J – Discussion Questions Handout 32 Appendix K – PANDAS/PANS Resources 33 Page 2 of 33 PANDAS/PANS Advisory Council 2019 Report to the General Assembly Executive Summary The Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) and Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) advisory council is established in the Code of Virginia [§32.1-73.9] to advise the Commissioner of Health on research, diagnosis, treatment and education relating to PANDAS and PANS. The advisory council is required to report to the Governor and General Assembly by December 1st of each year recommendations related to the following: 1. Practice guidelines for the diagnosis and treatment of PANDAS and PANS 2. -
Symptom Dimensions in OCD: Item-Level Factor Analysis and Heritability Estimates
Symptom Dimensions in OCD: Item-Level Factor Analysis and Heritability Estimates The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Citation Katerberg, Hilga et al. “Symptom Dimensions in OCD: Item-Level Factor Analysis and Heritability Estimates.” Behavior Genetics 40 (2010): 505-517. As Published http://dx.doi.org/10.1007/s10519-010-9339-z Publisher Springer Science + Business Media B.V. Version Final published version Citable link http://hdl.handle.net/1721.1/65885 Terms of Use Creative Commons Attribution Noncommercial License Detailed Terms http://creativecommons.org/licenses/by-nc/2.5 Behav Genet (2010) 40:505–517 DOI 10.1007/s10519-010-9339-z ORIGINAL RESEARCH Symptom Dimensions in OCD: Item-Level Factor Analysis and Heritability Estimates Hilga Katerberg • Kevin L. Delucchi • S. Evelyn Stewart • Christine Lochner • Damiaan A. J. P. Denys • Denise E. Stack • J. Michael Andresen • J. E. Grant • Suck W. Kim • Kyle A. Williams • Johan A. den Boer • Anton J. L. M. van Balkom • Johannes H. Smit • Patricia van Oppen • Annemiek Polman • Michael A. Jenike • Dan J. Stein • Carol A. Mathews • Danielle C. Cath Received: 28 May 2009 / Accepted: 19 January 2010 / Published online: 2 April 2010 Ó The Author(s) 2010. This article is published with open access at Springerlink.com Abstract To reduce the phenotypic heterogeneity of and translational studies, numerous factor analyses of obsessive-compulsive disorder (OCD) for genetic, clinical the Yale-Brown Obsessive Compulsive Scale checklist (YBOCS-CL) have been conducted. Results of these analyses have been inconsistent, likely as a consequence of Edited by Michael Lyons. -
Importance of Streptococci Infections in Childhood Neuropsychiatric Disorders
THE MEDICAL BULLETIN OF SISLI ETFAL HOSPITAL DOI: 10.14744/SEMB.2017.65487 Med Bull Sisli Etfal Hosp 2019;53(4):441–444 Case Report Importance of Streptococci Infections in Childhood Neuropsychiatric Disorders Serkan Kırık,1 Olcay Güngör,1 Yasemin Kırık2 1Department of Pediatric Neurology, Sutcu Imam University Faculty of Medicine, Kahramanmaras, Turkey 2Department of Clinical Microbiology and Infectious Diseases, Necip Fazil State Hospital, Kahramanmaras, Turkey Abstract Paediatric autoimmune neuropsychiatric disorders associated with streptococci (PANDAS) are important neuropsychiatric disor- ders in childhood. Streptococcus pyogenes infection associated with tics, obsessive-compulsive disorders, and chorea co-occur- rence is important. Swedo et al. have increased the awareness of this situation since 1998. How streptococcal infections give rise to this condition is not clear yet, but the severity of the symptoms is reduced by the treatment of streptococcal infections is important. Eight-year- nine-month-old girl presented with complaints of a 2-year history of upper respiratory tract infections and increased severity of blinking of eyes, throat cleaning, tic disorder and obsession with hand cleaning. In addition, choreiform movements were present and fluoxetine did not improve the symptoms. The patient was followed-up and treated with PANDAS pre-diagnosis. Streptococcus treatment and prophylaxis decreased the patient’s complaints. A six-year-four months old boy, admitted with abnormal hand and body movements, which increased severity after the school period, and causing deteriorated fine motor skills during infectious periods for two years. There were also complaints with vocal tics and obsessive-compulsive disorder in the form of throat cleaning. Treatment of S. pyogenes was administered in throat culture. -
Illinois Pandas/Pans Advisory Council
ILLINOIS PANDAS/PANS ADVISORY COUNCIL 2020 Report December 20, 2020 Compiled by: Wendy C Nawara, MSW Dareen Siri, MD, FAAAAI, FACAAI ILLINOIS PANDAS/PANS ADVISORY COUNCIL – 2020 REPORT TABLE OF CONTENTS ILLINOIS PANDAS/PANS ADVISORY COUNCIL ................................................................................. 3 UNDERSTANDING PANDAS/PANS ................................................................................................... 4 Clinical Presentation ........................................................................................................... 4 Epidemiology/Demographics .............................................................................................. 5 Etiology and Disease Mechanisms for PANDAS (Post-streptococcal symptoms) .......................... 6 STANDARD DIAGNOSTIC AND TREATMENT GUIDELINES ............................................................... 7 Absolute Criteria ................................................................................................................. 7 Major Criteria ...................................................................................................................... 7 Minor Criteria Group 1 ........................................................................................................ 7 Minor Criteria Group 2 ........................................................................................................ 7 Additional Supporting Evidence......................................................................................... -
Risk Assessment and Management in Obsessive–Compulsive Disorder David Veale, Mark Freeston, Georgina Krebs, Isobel Heyman & Paul Salkovskis
Advances in psychiatric treatment (2009), vol. 15, 332–343 doi: 10.1192/apt.bp.107.004705 ARTICLE Risk assessment and management in obsessive–compulsive disorder David Veale, Mark Freeston, Georgina Krebs, Isobel Heyman & Paul Salkovskis David Veale is an honorary harm to children may be tempted to play for safety SUMMARY senior lecturer and a consultant when conducting a risk assessment. However, a psychiatrist in cognitive behaviour Some people with obsessive–compulsive disorder person with OCD can be harmed by an incorrect or therapy at the NIHR Biomedical (OCD) experience recurrent intrusive sexual, Research Centre for Mental Health, unduly lengthy risk assessment, responding with aggressive or death-related thoughts and as a The South London and Maudsley increased doubts and fears about the implications result may be subjected to lengthy or inappropriate NHS Foundation Trust, King’s of their intrusive thoughts. At best this will lead College London, and The Priory risk assessments. These apparent ‘primary’ risks Hospital North London. Mark can be dealt with relatively easily through a careful to greater distress, avoidance and compulsive Freeston is Professor of Clinical understanding of the disorder’s phenomenology. behaviours, and mistrust of health professionals; Psychology at Newcastle University, However, there are other, less obvious ‘secondary’ at worst, to complete decompensation of the patient Newcastle upon Tyne. Georgina risks, which require more careful consideration. or break-up of the family. In reality, there is no need Krebs is a clinical psychologist working in the service for young This article discusses the differentiation of intrusive for overcautious reactions. Provided the clinician people with obsessive–compulsive thoughts and urges in people with OCD from has appropriate expertise in OCD, there are very disorder at the Maudsley Hospital, those experienced by sexual or violent offenders; rarely any serious doubts about the diagnosis. -
How a Controversial Condition Called PANDAS Is Gaining Ground on Autism
Spectrum | Autism Research News https://www.spectrumnews.org DEEP DIVE How a controversial condition called PANDAS is gaining ground on autism BY BRENDAN BORRELL 8 JANUARY 2020 Illustration and animation by Vanessa Branchi Adam Elliott was 2 years old when his parents began to suspect he might have autism. Adam had trouble making eye contact — one telltale sign of the condition — and there were other hints as well. He was a calm, inquisitive child most of the time, but some days at preschool, he would become unfocused and uncoordinated, fumbling with scissors as he tried to cut paper for art projects. By the time Adam entered elementary school, his traits had worsened. He began to experience severe separation anxiety and sensory overload in the noisy classroom. He became aggressive. When he was 6, for example, he believed his best friend was saying nasty things about him and scratched the friend in the face with a pencil. At home, Adam would often walk in circles, filled with anxiety. He eventually became so afraid that his food was poisoned, he refused to eat for long periods of time. Adam’s parents took him to a dozen different specialists during this time, including occupational therapists and psychologists. None were willing to attach a label to Adam’s condition, recalls his mother, Wendy Elliott. One doctor diagnosed Adam with attention deficit hyperactivity disorder (ADHD) and prescribed amphetamine/dextroamphetamine (Adderall), but it did little to quell the boy’s obsessive thoughts and behaviors. By 2015, when Adam was 8, Elliott began to fear she might have to have him hospitalized. -
Disorders, Musical Hallucinations, Musical Obsessions, Neurobiology
International Journal of Psychology and Behavioral Sciences 2020, 10(3): 51-62 DOI: 10.5923/j.ijpbs.20201003.01 Obsessions and Musical Hallucinations: The Neurobiology Underlying a Differential Diagnosis Mayra E. Dávila-Rivera, Hilda M. Rivera-Marín* Albizu University, San Juan Campus, San Juan, Puerto Rico Abstract This literature review has the purpose of establishing the difference between comorbid disorders with musical obsessions and hallucinations from a neurobiological perspective. Musical obsessions and hallucinations are unusual, with limited research, and their prevalence is underestimated [1,2]. Their pathological etiology can be confusing since it can fall within psychiatry, neurology and biology due to its symptomatic comorbidity; and it may not be recognized as generating suffering for the patient [1]. Neurobiology has made it possible to increase our knowledge of brain structures or circuits responsible for the behavior of subjects who suffer related disorders. Musical obsessions and hallucinations are disabling as they are detrimental to quality of life. Due to new discoveries in the different scientific disciplines, health professionals will establish a differential diagnosis, adequately address primary and underlying pathologies, and also facilitate the implementation of effective evidence-based models. Keywords Disorders, Musical hallucinations, Musical obsessions, Neurobiology 1. Introduction which are unattractive as a clinical research focus [9]. These conditions are chronic and disabling characterized by their Research has identified various disorders sharing similar low prevalence (less than 1,200 individuals), and high characteristics within the neurobiological model of the morbidity. They are scarcely researched, with more than prefrontal cortex. The comorbidity that exists between 80% originating genetically; many of them without a specific psychiatric, neurological and diseases associated with treatment. -
Obsessive-Compulsive Disorder and Tourette's Disorder
JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY Volume 20, Number 4, 2010 Guest Editorial ª Mary Ann Liebert, Inc. Pp. 235–236 DOI: 10.1089/cap.2010.2041 Obsessive-Compulsive Disorder and Tourette’s Disorder: Where Are We Now? Barbara J. Coffey, M.D., M.S.1 and Judith Rapoport, M.D.2 his special issue of the Journal provides an update on pedi- circuits involved in TD, which will allow clinicians to target spe- Tatric obsessive-compulsive disorder (OCD) and Tourette’s cific types of tics with more specific treatments. disorder (TD): where are we now, and where are we going? Tic Dr. Parraga and colleagues review pharmacotherapy for TD; an disorders and OCD are quite common in clinical practice; up to interesting historical report is included. For example, Itard (1825) 20% of school-age children develop tics, and 2–4% of prepubertal described ‘‘application of leeches along the spine, and thighs… or children may develop OCD. There is also a bidirectional overlap of cold river baths, … massages and gymnastics’’; Gilles de la Tourette tics and OCD symptoms, in that OCD symptoms have been re- himself in his original case reports in 1885 acknowledged tremen- ported in as many as 60% of patients with TD, while patients with dous difficulties in treating his patients, and reported using ‘‘isola- OCD may have a 20% lifetime risk of having tics. There are sim- tion, tonics, hydrotherapy and static electricity. …’’ We have come ilarities in phenomenology, psychiatric co-morbidity, genetic vul- along way since then, but there is still a long way to go in identifi- nerability, and approaches to treatment in both pediatric-onset cation of effective and safe treatments. -
ASPIRE PANS Overview Packet
S y m p t o m s , D i a g n o s i s , T r e a t m e n t Pediatric Acute-onset Neuropsychiatric Syndrome Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections Alliance to Solve PANS & Immune-Related Encephalopathies www.ASPIRE.care [email protected] 1. Abrupt, acute onset of 1. Presence of OCD and/or tics, Obsessive-compulsive disorder and/or particularly multiple, complex or Severe restricted food intake unusual tics 2. Concurrent presence of additional 2. Age Requirement (Symptoms of the behavioral or neurological symptoms disorder first become evident with similarly acute onset and severity between 3 years of age and puberty) from at least 2 of the 7 following categories: Acute onset and episodic (relapsing- 3. remitting) course 1.Anxiety, separation anxiety 2.Emotional lability or depression 3.Irritability, aggression, and/or 4. Association with Group A Streptococcal oppositional behaviors (GAS) infection 4.Behavioral or developmental regression 5.Deterioration in school performance (loss 5. Association with Neurological of math skills, handwriting changes, Abnormalities ADHD-like behaviors, executive functioning, etc.) Note: Comorbid neuropsychiatric symptoms are 6.Sensory or motor abnormalities, tics universally present in PANDAS, similar to the 7.Somatic signs: sleep disturbances, diagnostic criteria for PANS with similarly abrupt enuresis, or urinary frequency onset/exacerbation as the primary symptoms of Symptoms are not better explained by a PANDAS. In particular, the somatic symptoms 3. such as urinary frequency, mydriasis, and known neurologic or medical disorder insomnia, help differentiate PANDAS from 4. Age requirement – None Tourette syndrome or non-PANDAS OCD. -
Obsessive-Compulsive Disorder, Second Edition (WPA Series In
VOLUME 4 Obsessive-Compulsive Disorder Second Edition Edited by Mario Maj University of Naples, Italy Norman Sartorius University of Geneva, Switzerland Ahmed Okasha Ain Shams University, Cairo, Egypt Joseph Zohar Tel Aviv University, Israel WPA Series Evidence and Experience in Psychiatry VOLUME 4 Obsessive-Compulsive Disorder Second Edition WPA Series Evidence and Experience in Psychiatry Other Titles in the WPA Series Evidence and Experience in Psychiatry Volume 1ÐDepressive Disorders, Second Edition Mario Maj and Norman Sartorius Volume 2ÐSchizophrenia, Second Edition Mario Maj and Norman Sartorius Volume 3ÐDementia, Second Edition Mario Maj and Norman Sartorius Volume 5ÐBipolar Disorder Mario Maj, Hagop S. Akiskal, Juan Jose LoÂpez-Ibor and Norman Sartorius VOLUME 4 Obsessive-Compulsive Disorder Second Edition Edited by Mario Maj University of Naples, Italy Norman Sartorius University of Geneva, Switzerland Ahmed Okasha Ain Shams University, Cairo, Egypt Joseph Zohar Tel Aviv University, Israel WPA Series Evidence and Experience in Psychiatry Copyright # 2002 John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex PO19 8SQ, England Telephone (+44) 1243 779777 Email (for orders and customer service enquiries): [email protected] Visit our Home Page on www.wileyeurope.com or www.wiley.com First Edition printed in 2000. All Rights Reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, scanning or otherwise, except under the terms of the Copyright, Designs and Patients Act 1988 or under the terms of a licence issued by the Copyright Licensing Agency Ltd, 90 Tottenham Court Road, London W1T 4LP, UK, without the permission in writing of the Publisher. -
Homosexuality Anxiety: a Misunderstood Symptom Of
In: Leading-Edge Health Education Issues ISBN 978-1-60021-874-3 Editor: Lennard V. Sebeki, pp. 195-205 © 2008 Nova Science Publishers, Inc. Chapter VII Homosexuality Anxiety: A Misunderstood Form of OCD Monnica Williams University of Virginia, Department of Psychology Abstract Obsessive-compulsive disorder (OCD) involves unwanted thoughts and repetitive behaviors that can be highly distressing and disabling. Obsessive themes typically center on contamination, illness, worries about disaster, orderliness, and loss of control. Sexual obsessions are a common form of OCD, but it is not known how many of those with sexual obsessions experience homosexuality anxiety – an obsessive fear related to homosexual feelings, thoughts, or images. The phenomenology of OCD-related homosexuality anxiety is described and contrasted with an ambivalent homosexual orientation. Examples of OCD homosexuality anxiety are provided from on online OCD support forum. Mental health professionals who are unfamiliar with OCD may mistakenly attribute symptoms to a sexual identity crisis, resulting in greater distress and confusion in the patient. It is important that clinicians properly identify and treat this manifestation of OCD. More research is needed to quantify the prevalence of homosexuality anxiety and how to best tailor treatment. Keywords: obsessive-compulsive disorder, homosexuality, anxiety, assessment, sexual obsessions, HOCD, homophobia. About OCD Obsessive-compulsive disorder (OCD) is a psychiatric disorder that can cause severe distress, disability, and social impairment. Obsessions are unwanted, recurrent, disturbing thoughts that the person cannot suppress and which can cause overwhelming anxiety. 196 Monnica Williams Compulsions are repetitive, ritualized behaviors that the person feels driven to perform to alleviate the anxiety of the obsessions. -
Differential Binding of Antibodies in PANDAS Patients to Cholinergic Interneurons in the Striatum
HHS Public Access Author manuscript Author ManuscriptAuthor Manuscript Author Brain Behav Manuscript Author Immun. Author Manuscript Author manuscript; available in PMC 2019 March 01. Published in final edited form as: Brain Behav Immun. 2018 March ; 69: 304–311. doi:10.1016/j.bbi.2017.12.004. Differential binding of antibodies in PANDAS patients to cholinergic interneurons in the striatum Luciana Frick, Ph.D.1,#, Maximiliano Rapanelli, Ph.D.1,#, Kantiya Jindachomthong, BS1, Paul Grant, MD4, James F. Leckman, MD, Ph.D.2,3, Susan Swedo, MD4, Kyle Williams, MD, Ph.D.5,*, and Christopher Pittenger, MD, Ph.D.1,2,3,6,* 1Department of Psychiatry, Yale University 2Department of Psychology, Yale University 3Child Study Center, Yale University 4Pediatrics and Developmental Neuroscience Branch, National Institute of Mental Health 5Department of Psychiatry, Massachusetts General Hospital, and Harvard Medical School 6Interdepartmental Neuroscience Program, Yale University Abstract Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcus, or PANDAS, is a syndrome of acute childhood onset of obsessive-compulsive disorder and other neuropsychiatric symptoms in the aftermath of an infection with Group A beta-hemolytic Streptococcus (GABHS). Its pathophysiology remains unclear. PANDAS has been proposed to result from cross-reactivity of antibodies raised against GABHS with brain antigens, but the targets of these antibodies are unclear and may be heterogeneous. We developed an in vivo assay in mice to characterize the cellular targets of antibodies in serum from individuals with PANDAS. We focus on striatal interneurons, which have been implicated in the pathogenesis of tic disorders. Sera from children with well-characterized PANDAS (n = 5) from a previously described clinical trial (NCT01281969), and matched controls, were infused into the striatum of mice; antibody binding to interneurons was characterized using immunofluorescence and confocal microscopy.