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Abstract Book CONTENTS 1. FREE PAPERS ................................................................................................................3 1.1 Intraocular Inflammation, Uveitis & Scleritis ��������������������������������������������������������������������������������������������������������� 3 1.2 Retina (Medical) ���������������������������������������������������������������������������������������������������������������������������������������������������� 6 1.3 Retina (Surgical) �������������������������������������������������������������������������������������������������������������������������������������������������� 27 2. POSTERS .....................................................................................................................45 2.1 Intraocular Inflammation, Uveitis & Scleritis ������������������������������������������������������������������������������������������������������� 45 2.2 Retina (Medical) �������������������������������������������������������������������������������������������������������������������������������������������������� 53 2.3 Retina (Surgical) �������������������������������������������������������������������������������������������������������������������������������������������������� 85 3. E-POSTERS ���������������������������������������������������������������������������������������������������������������110 3.1 Intraocular Inflammation, Uveitis & Scleritis ����������������������������������������������������������������������������������������������������� 110 3.2 Retina (Medical) ������������������������������������������������������������������������������������������������������������������������������������������������ 117 3.3 Retina (Surgical) ������������������������������������������������������������������������������������������������������������������������������������������������ 136 4. VIDEOS ���������������������������������������������������������������������������������������������������������������������150 4.1 Intraocular Inflammation, Uveitis & Scleritis ����������������������������������������������������������������������������������������������������� 150 4.2 Retina (Surgical) ������������������������������������������������������������������������������������������������������������������������������������������������ 150 1 FREE PAPERS emerging as a major cause of exogenous Intraocular Inflammation, Uveitis & Scleritis endophthalmitis, replacing other causes (such as after cataract surgery, corneal pathology), Dec 09, 2017 (Sat) 11:00 - 12:30 a paradigm shift in the etiology of this Venue: Room 302 & 303 complication. Changing Trends in the Etiology of Dec 09, 2017 (Sat) 11:00 - 12:30 Exogenous Endophthalmitis: Is This a Paradigm Shift? Venue: Room 302 & 303 First Author: Jane FOO Co-Author(s): Jay CHANDRA Correlation of Panoramic Optical Coherence Tomography Angiography Characteristics Purpose: To describe a change in the etiology of Active and Healing Serpigenous- of cases of exogenous endophthalmitis from a Like Choroiditis With Indocyanine Green tertiary referral center in Australia from 2000 to Angiography 2017. First Author: Rakesh JUNEJA Co-Author(s): Ashish JAIN, Navneet MEHROTRA, Methods: Retrospective chart review. Manish NAGPAL, Avijit VISHNOI Results: A total of 20 presumed exogenous Purpose: To analyze the panoramic optical endophthalmitis cases were identified: 10 after coherence tomography angiography (OCTA) intravitreal injections (IVI group), while in the imaging characteristics of serpiginous-like non-IVI group, there were 6 cases after cataract choroiditis and to compare these findings surgeries and 4 secondary to corneal ulcers. with indocyanine green angiography (ICGA) There were no cases of endophthalmitis in features. the IVI group until 2013. From 2013 to 2017, cases due to IVI were about 2-fold the number Methods: Prospective cross-sectional study. of cases in the non-IVI group. Mean age was Multimodal imaging was performed in older in the IVI group (77 versus 61 years). The subjects with serpiginous-like choroiditis major indication for IVI was age-related macular using panoramic OCTA (NIDEK RS-3000), degeneration. Upon diagnosis, 100% in the IVI OCT (Heidelberg Spectralis), fundus group had visual acuity of counting fingers or autofluorescence, fluorescein angiography worse compared to 70% in the non-IVI group. (Heidelberg Spectralis), and ICGA. Morphologic In the IVI group, 9 out of 10 patients underwent features at the sites of choroiditis lesions were vitreous tap with intravitreal antibiotic injection analyzed using panoramic OCTA imaging and and all 10 cases required vitrectomy. The compared with ICGA with minimum 6 months tenth case underwent immediate vitrectomy of follow-up. with intravitreal antibiotics on the day of Results: Twenty eyes were included in presentation. In the non-IVI group, all 7 patients the study. In the active stage, the en face received intravitreal antibiotics upon diagnosis panoramic OCTA images demonstrated discrete while only 4 underwent vitrectomy. Visual acuity areas of flow void beneath the retinal pigment 3 months after treatment was comparable in epithelium–Bruch membrane layer suggestive both groups, ie, in the IVI group, 70% achieved of choriocapillaris hypoperfusion that vision 3/60 or better compared to 60% in the corresponded well with hypofluoroscence in non-IVI group. ICGA. In advanced stages of healing, preserved Conclusions: Intravitreal injections are now capillaries were observed corresponding to the 3 healed areas in ICGA. It gave a wider field of was achieved in 69.6% and 68.8% of 440 and view than conventional OCTA. 44 µg subjects, respectively. Tapering success with VH 0/0.5+ was higher in 440 μg vs 44 μg Conclusions: The panoramic OCTA images (43.5% vs 28.1%, P = 0.1676). Serious ocular are a useful noninvasive tool to study areas of adverse events (AEs) occurred in 11.1% (n = 5) activity in eyes with serpiginous-like choroiditis. of 440 μg and 16.7% (n = 5) of 44 μg intent-to- The changes observed during active and taper subjects. healing stages in panoramic OCTA correlated and corresponded well with ICGA images. Conclusions: Integrated analysis of the SAKURA program demonstrated that IVT Dec 09, 2017 (Sat) 11:00 - 12:30 sirolimus 440 μg every other month achieved statistically significant improvements in VH at Venue: Room 302 & 303 M5 in subjects with active NIU-PS. IVT sirolimus Corticosteroid Tapering Success With 440 μg demonstrated potential as an effective Every-Other-Month Intravitreal Sirolimus CST-sparing agent. for Noninfectious Uveitis of the Posterior Segment: Results of the SAKURA Program Dec 09, 2017 (Sat) 11:00 - 12:30 First Author: Kalpana Babu MURTHY Co-Author(s): Abu ABRAHAM Venue: Room 302 & 303 Purpose: To report corticosteroid (CST) Endogenous Endophthalmitis Complicated tapering success in subjects with noninfectious by Pyogenic Liver Abscess: A Review of 9 uveitis of the posterior segment (NIU-PS) Years’ Experience First Author: Lei receiving every-other-month intravitreal (IVT) GAO sirolimus. Purpose: Hepatic abscess induced Methods: The SAKURA program comprised endophthalmitis is one of the most common 2 phase III, multinational, multicenter, types of endogenous endophthalmitis. It is randomized, double-masked studies. Patients easily underdiagnosed or misdiagnosed in the had vitreous haze (VH) ≥1.5+ in the study early stage. The treatment is more complicated, eye at baseline. Subjects from both studies requiring multispecialty cooperation throughout comprised the integrated intent-to-treat (ITT) the whole process. We investigated the population evaluating sirolimus 440 μg (n = clinical features and treatment outcomes of 208) vs 44 μg active control (n = 208). Systemic endogenous endophthalmitis over the past 9 immunosuppressants and topical CSTs were years at 1 center. discontinued before baseline. VH = 0 and CST Methods: The clinical data of patients with tapering success (overall prednisone-equivalent hepatic abscess endophthalmitis treated in dose ≤5 mg/d without any rescue therapy) were Yantai Yuhuangding Hospital from June 2008 to assessed at month 5 (M5) in 46 subjects from July 2017 were analyzed retrospectively. the 440 µg group and 32 from the 44 µg group with overall prednisone-equivalent dose >5 Results: There was a total of 19 patients (10 mg/d at baseline (intent-to-taper population). male, 9 female; 21 eyes) with hepatic abscess Tapering success with VH 0/0.5+ at M5 was also induced endophthalmitis with the average assessed. Safety was assessed through month 6 age of 58.5. Patients were initially hospitalized (M6). in the hepatic biliary surgery department. Thirteen patients had diabetes, and 7 patients Results: A total of 21.2% and 13.5% of subjects had positive culture for Klebsiella pneumoniae (440 and 44 µg, respectively) in the integrated from vitreous body culture. Nineteen eyes were ITT population achieved the primary endpoint initially treated with intravitreal injection, and 2 of VH = 0 at M5 (P = 0.0381). Tapering success eyes underwent emergency vitrectomy. Among 4 19 eyes with injections, vitrectomy had to be DR (PDR) patients and 22 controls with performed in 8 eyes. Among the pars plana idiopathic epiretinal membranes. vitrectomy (PPV) group, 9 eyes retained light Results: We observed increased gene perception vision; visual acuity of 4 eyes was and protein expression of NLRP3, ASC, better than 0.1, and there was only 1 case of and caspase-1 in PBMCs from DR patients evisceration. In the injection
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