US 2010.0261682A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2010/0261682 A1 Sirén et al. (43) Pub. Date: Oct. 14, 2010

(54) METHOD AND MEANS FOR THE (86). PCT No.: PCT/SE2008/OS 1043 TREATMENT OF CACHEXA S371 (c)(1), (2), (4) Date: Jun. 8, 2010 (75) Inventors: Matti Sirén, Helsingfors (FI): Related U.S. Application Data Pontus Gallen-Kallela-Sirén, Helsingfors (FI) (60) Provisional application No. 60/994,061, filed on Sep. 17, 2007, provisional application No. 61/050,778, filed on May 6, 2008. Correspondence Address: (30) Foreign Application Priority Data PORTER WRIGHT MORRIS & ARTHUR, LLP INTELLECTUAL PROPERTY GROUP Sep. 17, 2007 (SE) ...... O7O2O76-1 41 SOUTH HIGH STREET, 28TH FLOOR Publication Classification COLUMBUS, OH 43215 (51) Int. Cl. A6II 3/665 (2006.01) (73) Assignee: Bioneris AB A6IP3/00 (2006.01) (52) U.S. Cl...... 514/144 (21) Appl. No.: 12/676,173 (57) ABSTRACT The present invention relates to the treatment of cachexia in a mammal by the use of a compound comprising a high density (22) PCT Filed: Sep. 17, 2008 negatively charged domain of vicinally oriented radicals. Patent Application Publication Oct. 14, 2010 Sheet 1 of 28 US 2010/0261682 A1

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