Example of how Amehsi Specification Indicators can be Mapped to Health Conditions and Health Statuses The information presented here may be covered by copyrights and patents Some of the Amehsi Factors which can be alleviated using Amehsi Specification Recommendations and Demise Oncology Leukemia Lymphoma HIV Information. This document may be protected by copyrights and patents

Choline Deficiency or Circumstantial Choline Deficiency from upregulated Choline Kinase Pathway or Kennedy Pathway Factors Causal Causal Causal Causal Causal

Homocysteine Required as Symptom, Correlated and Incipiently Causal, inhibits PEMT Required Causal Causal Causal

S-Adenosyl Homocysteine Downregulat Required as Symptom, Correlated and Incipiently Causal, inhibits PEMT Required Causal ed PEMT Causal

Trimethylamine-N-Oxide

Causal, inhibits PEMT Causal Causal Causal Incipient Enabler

Choline Kinase Upregulation

Causal Required Required uNOS Required Required as both PEMT1 or PEMT2 since Diagnostic Assay sometimes does not report if one of these is inhibited while the other is not. PEMT produces a Monomethylethanolamine that Phosphatidylethanolamine deteriorates PCBs, Dioxins, Aryl Methyltransferase Downregulation Cyclic Hydrocarbons, Alkyl Halides, other Carcinogens and produces Serine Proteases that catabolize Amino acids to thier most basic structures, resulting in purified cellular environment and embryonic Causal cellular plasticity Required Required Required

Inducible Nitric Oxide Synthase, Required, inhibits PEMT and upregulated Choline kinase, as well as causes Reactive Superoxide, Peroxynitrite, inhibits 5 PEMT, upregulates Choline Kinase Oxygen and Peroxynitrite which deteriorate tissues and biological molecules Required Required Required Required Some of the Amehsi Factors which can be alleviated using Amehsi Specification Recommendations and HPV Any Viral Disease Sepsis Diabetes Stroke Information. This document may be protected by copyrights and patents

Choline Deficiency or Circumstantial Choline Deficiency from upregulated Choline Kinase Pathway or Kennedy Pathway Factors Causal Causal Causal Required Causal

Required as Symptom, Required as Symptom, Homocysteine Correlated and Incipiently Correlated and Incipiently Causal Causal Causal Causal Required

Required as Symptom, Required as Symptom, S-Adenosyl Homocysteine Required as Symptom, Correlated and Correlated and Incipiently Correlated and Incipiently Incipiently Causal Causal Causal Causal Required

Required as principal cause of any sudden adverse health event, perioperative complication, sudden Trimethylamine-N-Oxide demise, or accompanying conditions. Required to be alleviated to improve Pathogenic Carotid Intima Media Causal Causal to Pathology Causal to Pathology Causal of Pathology Thickness Required for Involution of Hepatic, Thymic, Renal, Choline Kinase Upregulation Lymphatic and Splenic Immune Cellular Synthesis Required Required and differentiation Causal Required

Required to upregulate P53, enable P53 to inhibit Glut endocytosis of Glucose, inhibit Insulin Receptor, impair Pentose Phosphate Pathway, impair Glycolysis, inhibit Synthesis of Insulin by cellular entities, thereby causing accumulation of Glucose in circulatory pathway, requiring production of Insulin by Phosphatidylethanolamine Hepatic/Renal/Pancreatic Acid and systemic use of L-Arginine to Methyltransferase Downregulation cause Vasodilation for distribution of Insulin. Oxidative distress Required. A Principal activity of Thrombin is to inhibit then causes Pancreatic Islet B Cells to dedifferentiate through PEMT. Inhibited PEMT results in decreased Required for Involution of autoimmune function or Apoptosis/Necrosis. iNOS is not sensitive Phosphatidylcholine, decreased DHA which would Hepatic, Thymic, Renal, to depleted calcium while eNOS and nNOS may abate activity in otherwise inhibit Inflammation cascade, and results in Lymphatic and Splenic low calcium environment, resulting in constriction of the Caveolae increased exhibition of Membrane Phosphatidylserine Immune Cellular Synthesis which is required for Diabetes. Hepatic, Renal, and Thymic promoting a negatively polarized microenvironment Required Required and differentiation Involution and deterioration also may be impair Insulin Secretion. that enhances Coagulation Cascade

Inducible Nitric Oxide Synthase, Participative in Pathology Required to deplete intracellular calcium open apertures in Superoxide, Peroxynitrite, inhibits Required for entry through although generates Endoplasmic Reticulum to deplete Store Operated Calcium, then Causal by depleting Ca2+ promoting Caveolae PEMT, upregulates Choline Kinase remodeled inner plasma Antimicrobial Reactive Oxygen open apertures in Plasma Membrane to deplete extracellular Constriction and impairing eNOS/nNOS to cause Required , inhibits PEMT membrane Species Calcium as well as deplete extracellular L - Arginine, resulting vasoconstriction6 Some of the Amehsi Factors which can be alleviated using Amehsi Specification Recommendations and Demise Oncology Leukemia Lymphoma HIV Information. This document may be protected by copyrights and patents

Required, inhibits PEMT and upregulated Uncoupled Nitric Oxide Synthase Choline kinase, as well as causes Reactive Oxygen and Peroxynitrite which deteriorate tissues and biological molecules Causal Causal Causal Homocysteine Correlated

NF kB and AP1 for Latent HIV. DOI 10.1186/1742- 4690-11-45. It is known that Caspase 3 (or most any Cytotoxic Oncology Drug) connected to HIV TAT (or Activator Protein AP1 any other Transduction Domain) by way of molecular domain that can be segmented by HIV Protease, results in eradication of HIV. CRISPR Gene Editing Causal, inhibits PEMT and upregulated Choline also accomplishes the same and has been kinase Required Causal Causal successfully modeled in living small Mammals.

Specificity Protein SP1 Protein Causal, inhibits PEMT and upregulated Choline kinase Required Causal Causal SP1 is required for HIV LTR Expression.

Monocyte Chemoattractant Protein 1 Participated Causal Causal Causal Required

Symmetrical Dimethylarginine Causal, destabilizes Methylation Causal Causal Causal Causal

Asymmetric Dimethylarginine Causal, Destabilizes Methylation Causal Causal Causal Causal

Methylglyoxal Causal, promotes Lactate, Reactive Molecules, Advanced End Products Causal Causal Causal Causal

L - Lactate Required Causal Causal Causal Causal

D - Lactate Required Causal Causal Causal Causal

Nitrosamine, ChloroFluoro Radicals, Toxins, and persistent T Cellular Activation of Indoleamine 2,3 – 2Oxygenase (IDO), which inhibit PEMT. Causal Causal Causal Causal Causal

Thrombin Causal Causal Causal Causal Causal

Metabolic Acidosis Causal Causal Causal Causal Causal

Metabolic Alkalosis Causal Causal Causal Causal Causal

C - Reactive Protein Required Causal Causal Causal Causal 7 Phosphocholine Upregulation Correlated Required Causal Causal Causal Some of the Amehsi Factors which can be alleviated using Amehsi Specification Recommendations and HPV Any Viral Disease Sepsis Diabetes Stroke Information. This document may be protected by copyrights and patents

Participative in Pathology Participative in Pathology Uncoupled Nitric Oxide Synthase although generates although generates Promotes negatively polarized Super Oxide, Hydrogen Antimicrobial Reactive Antimicrobial Reactive Oxygen Peroxide, Alkyl Radicals and Peroxynitrite, enhancing Required Oxygen Species Species Causal of Pathology Coagulation

Activator Protein AP1

Required Causal Causal Causal of Pathology Inhibits PEMT

Specificity Protein SP1 Protein Causal Causal Causal Causal of Pathology Inhibits PEMT

Monocyte Chemoattractant Protein 1 Causal Causal Causal Causal of Pathology Causal

Symmetrical Dimethylarginine Causal Causal Causal to Pathology Causal of Pathology Causal

Asymmetric Dimethylarginine Causal Causal Causal to Pathology Causal of Pathology Causal

Methylglyoxal Required as best Diagnostic Causal Causal Indicator of Systemic Sepsis Causal of Pathology Causal

L - Lactate Causal Causal Causal to Pathology Causal of Pathology Causal

D - Lactate Causal Causal Causal to Pathology Causal of Pathology Causal

Nitrosamine, ChloroFluoro Radicals, Toxins, and persistent T Cellular Activation of Indoleamine 2,3 – 2Oxygenase (IDO), which inhibit PEMT. Causal Causal Causal to Pathology Causal of Pathology Causal

Causal, Thrombin is a primary inhibitor of PEMT in Thrombin Causal Causal Causal to Pathology Causal of Pathology the Pathogenic Microenvironment

Metabolic Acidosis Causal Causal Causal to Pathology Causal of Pathology Causal

Metabolic Alkalosis Causal Causal Causal to Pathology Causal of Pathology Causal

C - Reactive Protein Causal Causal Causal to Pathology Causal of Pathology Causal

Phosphocholine Upregulation Causal Causal Causal to Pathology Causal of Pathology Causal 8 Pervasive Disease and Any Genetic Condition Pathology

Homocysteine is known to be the principale cause of pervasive pathology and detrimental behavior, while along with PEMT impairment and upregulation of Choline Kinase, these cause mamallian physiology to dedifferentiation by inhibiting the Gastrulation Developmental Pathway and its maintenance. The Gastrulation Pervasive Genetic pathway enables the Condition are caused by three layers of Human factors here, are epigenetic Physiology to emerge and can be alleviated with doing development and CRISPR Gene Editing persist, while Technology Homocysteine along wiht inhibition of PEMT and upregulation of Choline promote the resection of Anatomy by inhibiting Gastrulation associated pathways. Mammalian Physiology maintains the Methylation Pathway as the primary pathway enabling plasticity, resection of anatomy, and redevelopment/regener ation of anatomy.

9 Amehsi Specification Environment and Behavioral Assay Patents and Trademarks Apply to this Material and all Amehsi Material Location of Sources of iNOS and Inflammation Power Measured in Units

Unfiltered Spigot Outlet Power Factor Level Strip Power Fluorine? Substantial Hotspot Found meter activity or Hotspot Found with X Units of Located Chlorine? duration with X Units of Energy Here Bromine? Energy Iodine? Spigot Spigot Outlet Lead? Unfiltered Unfiltered Aromatic Sleeping Hydrocarbon Power Wireless Hotspot Found Area for Strip Dioxins Networking or with X Units of Patient Communications Energy Device Aflatoxin B Hotspot Found with X Units of Aflatoxin B Energy Spigot Device Other Filtered Outlet Interface Apertures

Distance from other Homes for Persistent Transformer Distance from Road or Power or Hotspot Found Third Party Influence Hotspot Found at X Potential effect from Third Communication with X Units of or Effect with X Units of Distance Party Devices with Sudden Substation at X Energy Energy from Home or Ephemeral Effect Distance from Home

These factors can be improved by Amehsi and Supplies can be obtained from EMFPRotectionstore.com, EMFBlues.com or other Recommendations other entities. Location of Sources Influence to Perception, Cognition, Biological Function and Behavior

Energy, Fields, Magnetic, Atmospheric, Ionic, sound, subsonic, Cognitive hypersonic, Cognitive Behavioral Stimuli, Center fields or other Center Observation or Pattern, Scanning Device influence Scanning Device Survey influence, Field or modulated Not Connected Not Connected Connected to Connected to factor to Human Yes or No to Human Yes or No Human Yes or No Human Yes or No Measurable on Measurable on Detrimental/ Detrimental/ Device or Device or Optimal Optimal spontaneous spontaneous Inclination or Inclination or Change? Change? Behavior? Behavior? Measurable on Measurable on Detrimental/ Detrimental/ Device or Device or Optimal Optimal spontaneous spontaneous Inclination or Inclination or Change? Change? Behavior? Behavior? Measurable on Measurable on Detrimental/ Detrimental/ Device or Device or Optimal Optimal spontaneous spontaneous Inclination or Inclination or Change? Change? Behavior? Behavior? Measurable on Measurable on Detrimental/ Detrimental/ Device or Device or Optimal Optimal spontaneous spontaneous Inclination or Inclination or Change? Change? Behavior? Behavior? Measurable on Measurable on Detrimental/ Detrimental/ Device or Device or Optimal Optimal spontaneous spontaneous Inclination or Inclination or Change? Change? Behavior? Behavior? www.news.nationalgeographic.com/news/2013/08/130801-tan-le-portable-brain-scanning-headsets-neuroscience/ PMCID PMC3914802 These factors can be www.orgonelab.org/cart/ylemeter.htm improved by Amehsi www.arstechnica.com/tech-policy/2015/11/beware-of-ads-that-use-inaudible-sound-to-link-your-phone-tv-tablet-and-pc/ and other www.faim.org/measurement-of-the-human-biofield-and-other-energetic-instruments Recommendations Social and Environmental Survey

Places on Internet or In Systems which are Places on Internet or In Systems which are similar to or associated with the outcome, similar to or associated with the outcome, places it occurred or entities with which it places it occurred or entities with which it is associated. is associated.

Status Okay or Status Okay or Factor Status Factor Status Indicative Indicative

Speaks English or Stabled Assured Local Language Housing Status Local Language is Second or Ancillary Language Access to Shelter Status Resides in local regional area where demise is used as a Access to Adequate sanction Nutrition Status Resides in a National Entity which utilizes demise as a sanction Dependency or Compulsive Status Behavioral Health Condition Economic Status

Cognitive Condition

Chronic Conditions

Frequent user of Emergency Services Access to Nutritional Factors, Stably These factors can be improved by Amehsi and other Recommendations Social and Environmental Survey

Individuals, Groups, Organizations or Systems which benefited from the Outcomes, Enabled or Allowed the Outcome, or might Benefit from the incipient/proximate causal factors not being adequately remediated.

Outcome, Internet Site, status, or event Location, Similar Factor System and Date

These factors can be improved by Amehsi and other Recommendations Location of Sources Influence to Perception, Cognition, Biological Function and Behavior

Places on Internet or In Systems Programs, Services which are similar to or associated or capabilities with the outcome, places it Number of People experiencing the Deprivation, which were not occurred or entities with which it is same outcome before and after this traumatic afforded associated. instance event, or health adequately before status outcome experienced before outcome Services or Outcome, Organization, Internet Site, capabilities which status, or event Program or Location, Connected to were not obtained Similar Factor Before After Requires new System and Yes or No or were not Human Program Date adequate

DOI 10.1080/10926771.2017.1330294 These factors can be www.psychiatrictimes.com/articles/traumatic-stress-and-human-behavior improved by Amehsi and other Recommendations ISBN 052180132X Amehsi Super Diagnostic and Causal Indicators Mapped to Diagnostic Capabilities, Indicative Levels, Natural/Wholistic Therapeutics and Biomedical

➢Factors are not listed by Priority or particular sequence to prevent participation in producing biophysiological spirals Factor Indicative Information Wholistic Factors Information AP-1(X) A Diagnostic A study suggests the Jun- HMG-CoA Reductase Inhibitors utilized for Choline, Trimethylglycine, Folate/Methylfolate, Oncology Gene test for AP-1 can B and Fra-1 may be High Cholesterol or Cholesterol management Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, Expression. be found at outstanding Biomarkers prevent mevalonate pathway synthesis of Omega-3 Fatty Acids, Whole Food Organic Vitamins, www.abcam.co able to discriminately terpenoids and Isoprenoids which inhibit AP-1. Complete Minerals, Flavonoid/Carotenoid/Phytochemical Myrrh and m/ap1-c- differentiate Neoplasm Inhibitors of AP-1 also include Cycloinumakiol Supplement, Glandular Mix, KAL SOD3 or other Frankincense fosfosbfra1c- tissue spatially in the Inumakal, Inumakoic acid, Norditerpenes from Antioxidant Mix with Catalase and Superoxide Dismutase, inhibit junjund- same adjacent tissues. an the large Evergreen Tree Podocarpus Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, Cyclooxygenas transcription- DOI 10.1186/1471-2407- Latofolius. Heparin decreases the affinity of Inhibitors of AP-1(x), including Citrus Fruit with e , CFOS and factor-assay-kit- 13-441 FRA-1 was AP-1 to DNA, particularly reducing its Peelings/Rinds, Inhibitors of SP-1(X), Management of CJUN, thereby colorimetric- useful at determining integration into the TPA/PMA response Homocysteine, Management of S-Adenosyl Homocysteine also inhibiting ab207196.html. Estrogen Receptor Alpha element. DOI 10.1161/01.RES.75.1.1. or S-Adenosyl Homocysteine inhibitors, inhibitors of AP1 and SP1 96 Tests for Negative and Tanshinone IIA from Salvia P. Mormordin I Inducible Nitric Oxide Synthase, Inhibitors of Uncouple activation. DOI $1,489.00 Progesterone Receptor analog of Ampelopsis Radix Oleanolic Acid Nitric Oxide Synthase and its Reactive Molecular Species 10.1038/srep13 www.tuftshealth Negative as well as Glycosides. Avoid Doxycycline unless a (L-Arginine, Tetrahydrobiopterin, NADPH, Superoxide 668 plan.com/docum Triple Negative specific phenotype match has been generated, Dismutase, Catalase, Glutathione, ents/providers/g Oncology from other although Doxycycline can be effective. Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, uidelines/medica Oncology Reversions www.focusbiomolecules.com/tanshinone-iia- Complete B-Vitamins with B-12 Methylcobalamin, l-necessity- The literature was not ap-1-transcription-factor-inhibitor/. DOI Uridine, Prebiotic/Probiotic to Manage Inflammation guidelines/genet able to present a precise 10.1016/j.bbrc.2005.09.113. Factors Produced during Ingestion of some Choline Dense ic-testing-gene- typical or optimal www.marketreportscenter.com/reports/170707/t Foods, Enzymes which metabolize these factors or expression-for- molarity for AP-1 and it ranscription-factor-activator-protein-1-ap-1- synthesize these factors as well as precursors to these can is recommended that a inhibitors-pipeline-insights-2016. AP-1, factors, Water, Phosphatidyl-Monomethylethanolamine Mepacrine, practice establish optimal however, is required to be activated to induce (Phosphatidylmonomethylethanolamine or PMME), Nanoquinicrine, or typical from healthy Apoptosis when Leukemia is being treated Human Rubisco, Recombinant Rubisco, Rubisco Agonists Quinicrine, tissues in patients with using Bufalin. Oncogene, Volume 16, Pages or Rubisco Modulators, Polyacetylates, Atabrine inhibit optimal health. 779 to 787, 1998. AP1 inibition also occurs Phosphatidylethanolamine, Phosphatidylethanolamine AP1. Harpagophytum with resveretrol, Quercetin, Chlorogenic Aicd, Methyltransferase, Methyltetrahydrofolate Reductase, procumbens is known to Red Raspberry Anthocyanins, Honokiol, Betaine Homocysteine Methyltransferase, Ancient Pink inhibit AP-1. Pycnogenol, Licorice, Naringenin, Kaempferol, Himalayan Sea Salt instead of Table Salt. Astragulus/Astragaloside IV, Andrographis, Apigenin, Pycnogenol, Retinoic Acid and other factors. Factor Indicative Information Wholistic Factors Information

NAD+ Typically NAD+ depletion resultant of inhibition of PEMT, inhibited Choline, Trimethylglycine, Folate/Methylfolate, indictive when Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, Synthesis of RNA/DNA by PEMT’s downregulation of glycolysis and below 40 or at Omega-3 Fatty Acids, Whole Food Organic Vitamins, downregulation of the Pentose Phosphate Pathway, followed by DNA repair and least when below Complete Minerals, Flavonoid/Carotenoid/Phytochemical Gene Transcription occurring millions of instances each day in which PARP and 22 Micromoles Supplement, Glandular Mix, KAL SOD3 or other PARS deplete NAD+ to produce gradients through which material for per liter. Antioxidant Mix with Catalase and Superoxide Dismutase, biosynthesis or repair are recruited, culminates in directing of Pyruvate through Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, Pyruvate Dehydrogenase Activity into Lactate Anion because this transforms Inhibitors of AP-1(x), including Citrus Fruit with NADH into NAD+. However, Choline Dehydrogenase activity utilizes an Peelings/Rinds, Inhibitors of SP-1(X), Management of electron Acceptor such as NAD+ to produce Betaine Aldehyde from Choline Homocysteine, Management of S-Adenosyl Homocysteine while Betaine Aldehyde Dehydrogenase uses NAD+ and H2O to also to produce or S-Adenosyl Homocysteine inhibitors, inhibitors of Betaine, NADH and H+. Both of these enzymic catalyzes can occur in the Inducible Nitric Oxide Synthase, Inhibitors of Uncouple opposite direction to synthesize Choline from Betaine. Nitric Oxide Synthase and its Reactive Molecular Species DHA and EPA both result in upregulation of NAMPT which results (L-Arginine, Tetrahydrobiopterin, NADPH, Superoxide in increases in NAD+ which can assist in alleviating depletion of NAD+. The Dismutase, Catalase, Glutathione, early literature observes that Choline to Betaine Aldehyde to Betaine Catalysis is Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, not reversable, presumably because the depletion of NAD+ during choline Complete B-Vitamins with B-12 Methylcobalamin, inadequacy was not known and presumably because Eagle’s Medium had not Uridine, Prebiotic/Probiotic to Manage Inflammation been widely utilized. Digitial Object Identifier 10.1271/bbb1961.49.3623. Factors Produced during Ingestion of some Choline Dense PMID 13192104. Foods, Enzymes which metabolize these factors or synthesize these factors as well as precursors to these Digital Object Identifier 10.1007/978-0-387-30378-9_18 Nicotinamide Adenine Dinucleotide or factors, Water, Phosphatidyl-Monomethylethanolamine NAD is replenished by Nicotinamide Phosphoribosyltransferase NAMPT, (Phosphatidylmonomethylethanolamine or PMME), Nicotinamide Riboside Kinase 1 and Nicotinamide Riboside Kinase 2. Human Rubisco, Recombinant Rubisco, Rubisco Agonists Nicotinamide Mononucleotide, Nicotinamide Riboside, Melatonin, NADH, Beta- or Rubisco Modulators, Polyacetylates, NADH, NAD+ and Adenosine may enable enhanced synthesis of NAD+ levels. Phosphatidylethanolamine, Phosphatidylethanolamine NAMPT utilizes Nicotinamide and 5-Phosphoribosyl-1-Pyrophosphate to produce Methyltransferase, Methyltetrahydrofolate Reductase, Nicotinamide Mononucleotide and Pyrophosphate. NAMPT is also known as Betaine Homocysteine Methyltransferase, Ancient Pink Nicotinamide Phosphotransferase. Himalayan Sea Salt instead of Table Salt. Factor Indicative Information Wholistic Factors Information NAD+ Typically Nicotinate Riboside Kinase bidirectionally produces ADP and Nicotinate Beta-D- Choline, Trimethylglycine, Folate/Methylfolate, indictive when Ribonucleotide from ATP and Beta-D-Ribosylnicotinate. Nicotinamide Riboside Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, below 40 or at Kinase 2, NMRK2, catalyzes the production of Nicotinamide Mononucleotide Omega-3 Fatty Acids, Whole Food Organic Vitamins, least when below from Nicotinamide Riboside as well as catalyzes the production of Nicotinic Acid Complete Minerals, Flavonoid/Carotenoid/Phytochemical 22 Micromoles Mononucleotide from Nicotinic Acid Riboside, performing the addition of ATP to Supplement, Glandular Mix, KAL SOD3 or other per liter. Beta-D-Ribosylnicotinate to bidirectionally produce ADP, H+ and Nicotinate Antioxidant Mix with Catalase and Superoxide Dismutase, Beta-D-Ribonucleotide in its canonical pathway of catalysis. NMRK1 and Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, NRK1, as well as NRK2 and NMRK2 are utilized supplantively of each other. Inhibitors of AP-1(x), including Citrus Fruit with Peelings/Rinds, Inhibitors of SP-1(X), Management of NAD+ is synthesized from Tryptophan and its availability has been Homocysteine, Management of S-Adenosyl Homocysteine experimentally correlated to improved duration of being, according to study or S-Adenosyl Homocysteine inhibitors, inhibitors of which observes that the Tryptophan pathway for synthesis of NAD+ is potentiated Inducible Nitric Oxide Synthase, Inhibitors of Uncouple by Quinolinate Phosphoribosyltransferase which decreases the availability of Nitric Oxide Synthase and its Reactive Molecular Species Quinolinate when supplying NAD+ from Tryptophan, such that Acute Chronic (L-Arginine, Tetrahydrobiopterin, NADPH, Superoxide Kidney disease exhibition and progression has been correlated to increased levels Dismutase, Catalase, Glutathione, of Quinolinate and comparative decreases in Tryptophan in a measure known as Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, Quinolinate/Tryptophan or uQ/T ratio. Another article observes that NAD+ has Complete B-Vitamins with B-12 Methylcobalamin, been correlated in studies to increased duration of Health and duration of Vital Uridine, Prebiotic/Probiotic to Manage Inflammation Being, while also being able to assist maintaining optimal Hepatic function and Factors Produced during Ingestion of some Choline Dense Renal Function, particularly through the inhibition of a ACMSD, a Competitor Foods, Enzymes which metabolize these factors or for metabolites in the pathway in which Tryptophan becomes NAD+. ACMSD is synthesize these factors as well as precursors to these highly considered among Animalia. ACMSD, 2 – Amino – 3 – Carboxymuconate factors, Water, Phosphatidyl-Monomethylethanolamine 6 Semialdehyde Decarboxylase, metabolizes the production of Alpha- (Phosphatidylmonomethylethanolamine or PMME), Aminomuconate Semialdehyde from Alpha-Amino-beta-Carboxymuconate- Human Rubisco, Recombinant Rubisco, Rubisco Agonists epsilon-Semialdehyde. The Canonical ACMSD catalysis is presented as 2 – or Rubisco Modulators, Polyacetylates, Amino – 3 – Carboxymuconate – 6-Semialdehyde and H+, are both directed Phosphatidylethanolamine, Phosphatidylethanolamine bidirectionally toward 2-Aminomuonate 6-Semialdheyde and CO2. Methyltransferase, Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table Salt. Factor Indicative Information Wholistic Factors Information NAD+ Typically The conservation of ACMSD spans from the Caenorhabditis Elegans, to Choline, Trimethylglycine, Folate/Methylfolate, indictive when Murine to Human populations, thereby including one of the most successful Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, below 40 or at organisms in models of expanded vital being, which include enhancement of span Omega-3 Fatty Acids, Whole Food Organic Vitamins, least when below of vital being by many multiples of that typically exhibited. ACMSD Inhibitors Complete Minerals, Flavonoid/Carotenoid/Phytochemical 22 Micromoles may be potent enablers of NAD+. Supplement, Glandular Mix, KAL SOD3 or other per liter. PMCID PMC5518663 Antioxidant Mix with Catalase and Superoxide Dismutase, PMID 30127395 Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, Q8TDX5. ACMSD Human. 2-Amino-3-Carboxymuconate - 6 – Semialdehyde Inhibitors of AP-1(x), including Citrus Fruit with Decarboxylase. Uniprot Database. Peelings/Rinds, Inhibitors of SP-1(X), Management of Nature Magazine. 2018. Digital Object Identifier 10.1038/s41586-018-0645-6 Homocysteine, Management of S-Adenosyl Homocysteine Nicotinamide, Nicotinic Acid, Tryptophan, Nicotinamide Riboside, NAD+, or S-Adenosyl Homocysteine inhibitors, inhibitors of NADH, Nicotinamide Mononucleotide, inhibitors of ACMSD, 2-Amin0-3- Inducible Nitric Oxide Synthase, Inhibitors of Uncouple Crboxymuconate-6-Semialdehyde, Quinolinate Phosphoribosyltransferase, Nitric Oxide Synthase and its Reactive Molecular Species Nicotinamide Phosphoribosyltransferase NAMPT, Nicotinamide Riboside Kinase (L-Arginine, Tetrahydrobiopterin, NADPH, Superoxide 1 and Nicotinamide Riboside Kinase 2. Nicotinamide Mononucleotide, Dismutase, Catalase, Glutathione, Nicotinamide Riboside, Melatonin, NADH, Beta-NADH, NAD+ and Adenine Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, may enable enhanced synthesis of NAD+ levels. Nicotinamide, 5- Complete B-Vitamins with B-12 Methylcobalamin, Phosphoribosyl-1-Pyrophosphate, Nicotinamide Mononucleotide, Pyrophosphate, Uridine, Prebiotic/Probiotic to Manage Inflammation Beta-D-Ribonucleotide, NMRK1 and NRK1, as well as NRK2 and NMRK2 can Factors Produced during Ingestion of some Choline Dense enhance NAD+. Vitamin B3, Niacin and Niacinamide potentiate NAD+. Foods, Enzymes which metabolize these factors or synthesize these factors as well as precursors to these factors, Water, Phosphatidyl-Monomethylethanolamine (Phosphatidylmonomethylethanolamine or PMME), Human Rubisco, Recombinant Rubisco, Rubisco Agonists or Rubisco Modulators, Polyacetylates, Phosphatidylethanolamine, Phosphatidylethanolamine Methyltransferase, Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table Salt. Factor Indicative Information Wholistic Factors AP-1(X) AP-1 is Analytically Berberine, Nordihydroguaiaretic Choline, Trimethylglycine, Folate/Methylfolate, Oncology activated by Significant Ranges acid, citrus fruits with the Rinds, Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, Gene Protein Kinase Exhibited by Pulp and Peelings. Interestingly, Omega-3 Fatty Acids, Whole Food Organic Vitamins, Expression. A. AP-1 Healthiest Patients Nobiletin from citrus peelings of Complete Minerals, Flavonoid/Carotenoid/Phytochemical inhibits PEMT. Observed in Practice. C. Unshiu. C Unshiu or Satsuma Supplement, Glandular Mix, KAL SOD3 or other AP-1 inhibits DHA and EPA from Mandarin, Citrus Sinensis or Antioxidant Mix with Catalase and Superoxide Dismutase, Gold is Telomerase. Omega 3, but not other citrus fruits which are Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, among the AP-1 Arachidonic Acid polymethoxylated flavones. Inhibitors of AP-1(x), including Citrus Fruit with Divalent upregulates inhibit Epidermal Circumin, Sulforaphane, Peelings/Rinds, Inhibitors of SP-1(X), Management of Metal Ions Choline Kinase. Growth Factor, AP-1, Gingerol, Naproxen, and Aspirin Homocysteine, Management of S-Adenosyl Homocysteine which can AP-1 stabilizes and TPA/PMA, but inhibit AP-1 Neoplasm activity. or S-Adenosyl Homocysteine inhibitors, inhibitors of enable emerged Arachidonic Acid DOI Inducible Nitric Oxide Synthase, Inhibitors of Uncouple PEMT genetic, abrogates DHA/EPA 10.1016/J.BBRC.2013.08.029. Nitric Oxide Synthase and its Reactive Molecular Species function. epigenetic and inhibition of these AP-1 Inhibitors, TAM67 in (L-Arginine, Tetrahydrobiopterin, NADPH, Superoxide DOI: differentiation factors. PMCID particular, are known to Dismutase, Catalase, Glutathione, 10.1038/nch associated PMC34699 completely, that is completely, Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, em.2836. change by AP-1 levels have been abrogate or impede Breast Complete B-Vitamins with B-12 Methylcobalamin, Uridine, potentiating found to require Oncology Proliferation that Prebiotic/Probiotic to Manage Inflammation Factors decreased increased levels of involves IGF-1, EGF, Heregulin- Produced during Ingestion of some Choline Dense Foods, telomeric exhibition to result in Beta2, BFGF, and Estrogen Enzymes which metabolize these factors or synthesize these repeats and Oncology. This including when AP-1 was factors as well as precursors to these factors, Water, cellular linage increased level is specifically induced by Phosphatidyl-Monomethylethanolamine senescence. higher than that Upregulators and including when (Phosphatidylmonomethylethanolamine or PMME), Human required for optimal AP-1 was constitutively Rubisco, Recombinant Rubisco, Rubisco Agonists or biological activity. expressed. Myricetin inhibits AP- Rubisco Modulators, Polyacetylates, 10.1006/bbrc.2000.377 1, 12-Tetradecanoylphorpbol-13- Phosphatidylethanolamine, Phosphatidylethanolamine 7 Clinical studies acetate (TPA) activity which is Methyltransferase, Methyltetrahydrofolate Reductase, confirm Berberine and required by AP-1 as well as Betaine Homocysteine Methyltransferase, Ancient Pink AP1 Inhibition are inhibits Epidermal Growth Factor Himalayan Sea Salt instead of Table Salt. therapeutic for HPV (EGF). and HPV enabled Oncology. Factor Indicative Information Wholistic Factors to Accompany Therapeutics Information Homocysteine. Homocysteine S-Adenosyl Homocysteine and Homocysteine Choline, Trimethylglycine, Folate/Methylfolate, Glutathione, Over a decade of unequal to between Inhibitors or chelators/depleting of these Probiotic/Prebiotic, Complete-B Vitamins, Omega-3 Fatty Acids, utilization 6 and 3 Micromoles Homocysteines, Cystathionine Beta-Synthase or Whole Food Organic Vitamins, Complete Minerals, experience, Per Liter. CBS, BHMT, MTHFR, Methionine Synthase, Flavonoid/Carotenoid/Phytochemical Supplement, Glandular Homocysteine Homocysteine Choline/Phospholipid Pathway, Choline Kinase Mix, KAL SOD3 or other Antioxidant Mix with Catalase and below 7 begins to cause Pathway. DZ2002 [methyl 4-(adenin-9-yl)-2- Superoxide Dismutase, Choline Kinase Inhibitors, Tyrosine Micromoles per detrimental effects hydroxybutanoate]. DOI: 10.1124/jpet.104.080416 Kinase Inhibitors, Inhibitors of AP-1(x), including Citrus Fruit liter predicts a 500 including activation . Ribavirin inhibits S-Adenosyl Homocysteine with Peelings/Rinds, Inhibitors of SP-1(X), Management of to 1 decrease in of Monocytes at Hydrolase and is an Immunosuppressant. DOI Homocysteine, Management of S-Adenosyl Homocysteine or S- demise among 0.000000000014794 10.1016/j.bmc.2007.08.029. Thetins are known to Adenosyl Homocysteine inhibitors, inhibitors of Inducible Nitric populations in 606 Micromoles per reduce Homocysteine 700 times more efficiently Oxide Synthase, Inhibitors of Uncouple Nitric Oxide Synthase study of Aged. liter. PMID that Betaine or Glycine-betaine. Danshen or Red and its Reactive Molecular Species (L-Arginine, 16157236. Sage is known to assist in reducing Homocysteine. Tetrahydrobiopterin, NADPH, Superoxide Dismutase, Catalase, Homocysteine at Zinc, Iron, and Diatomic Metal Cations, including Glutathione, Citrulline/Arginine/Ornithine), NAD+, Hyaluronic 0.000000000184932 Magnesium and Manganese can assist. Acid, Complete B-Vitamins with B-12 Methylcobalamin, 581 Dithiothreitol, Mercaptans, Dimethylacetothetin, Uridine, Prebiotic/Probiotic to Manage Inflammation Factors Micromoles per S-Methylmethionine, Dimethylsulfonioacetate, Produced during Ingestion of some Choline Dense Foods, Liter results in Danshen or Red Sage, Choline, Folate, Enzymes which metabolize these factors or synthesize these MRNA and Protein Trimethylglycine, Glutathione, Reduced factors as well as precursors to these factors, Water, of Inflammation and Glutathione, Glutathione Peroxidase, a Complete Phosphatidyl-Monomethylethanolamine Cytokines including B Vitamin Supplement, B-12 Methylcobalamin, (Phosphatidylmonomethylethanolamine or PMME), Human TNF-Alpha, IL1- B6, N-Acetyl L-Cysteine, Sulfobetaines, Rubisco, Recombinant Rubisco, Rubisco Agonists or Rubisco Beta, IL-6, IL-8, IL- Sulfocholines, as well as depletion of Modulators, Polyacetylates, Phosphatidylethanolamine, 12, as well as Dimethylglycine through GNMT by providing Phosphatidylethanolamine Methyltransferase, downregulation of Glycine, as depletion of Dimethylglycine by using Methyltetrahydrofolate Reductase, Betaine Homocysteine Migration Inhibitor Riboflavin, Zinc and 5,6,7,8 Tetrahydrobiopterin, Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Factor and other factors presented here can enable Table Salt. Cobalamin and AdenosylCobalamin. MRNA/Protein. Homocysteine to be lower than 6 Micromoles per liter and even become much nearer to 1 Micromole per Liter. Factor Indicative Information Information Wholistic Factors to Accompany Therapeutics

Homocysteine Dimethylthetin. Sulfobetaine or S-Methylmethionine. depletion factors Dimethylacetothetin. Acetylated Factors. include Sulfur dimethylsulfonioacetate. Acetate, Sulfonium factors such as sulfur exhibiting Methionine, Cysteine or others, as well as Methylatioin factors. exhibition molecules, Ethylmethylthetin Sulfobetaines, Dimethyl-Alpha-Propriothetin Sulfocholines, Dimethyl-beta-Propriothetin. Methylation factors, Sulfobetaine or S-methylmethionine, or Methylation factors and Methionine. Thetins, Thetines, Ethylmethyl-Beta-Propriothetin Methylmercaptains, Dimethyl-Gamma-Butyrophenone. The Chem Spider suggests Phenones and Phenols are exchangeable within the Properties of 2-Acetylphenol. Methylation Sulphones and factors. Butyryl factors. molecules with Methionine Sulfur particularly Methylsulfonium. Sulfur and Methyl factors. when the sulfur is not Trimethylsulfonium. Sulfur and Trimethylated factors. obscured or Butyldimethylsulfonium prevented from being Ethyldimethylsulfonium accessed by the Dimethylpropriothetin attachment of Chiral S-Adenosyl-Methionine Sulfonate molecular factors. 5 - Methylthioadenosine Methylethylacetothetin Sulphocholine Trimethylselenonium + SelenoBetaine, Selenobetaine Methylester, and Sulfobetaine Phosphate, pyrophosphate. Methionine, suggesting competitive inhibition between methionine sulfoxide dimethyl sulfone Thetins include S-methylmethione, and does not reduce the requirement for ATP and Methionine Methionine sulfoxide. S-Methylmethionine Sulfonium is known to improved wound healing and prevent digestive pathway ulceration, as well as if exhibited in Cabbage, Cabbage Juice, and Satsuma Mandarin Oranges. Thetin-Homocysteine Methylpherase Catalyzes Thetins, particularly Dimethylthetin, Dimethylacetothetin discovered in 1878, Dimethylsulfonioacetate, and Dimethlpropriothetin 700 to 400 times more potently than other factors. Thioglycolic Acid is a central component of Medicinal Chemistry. NAD+ depletion occurs also resultant of inadequate choline, inhibited PEMT, PEMT2 in particular, and upregulated P53, resulting Hyperproliferation of Mitotic capable cellular entities and Apoptosis through Parthanatos of Senescent/Completely Differentiated Cellular Entities. NAD+/Niacin may be essential. Factor Indicative Information Information Wholistic Factors to Accompany Therapeutics Homocysteine. These suggest that Managing www.sciencedaily.com/relea Choline, Trimethylglycine, Folate/Methylfolate, Glutathione, It is likely that Homocysteine can be Choline, ses/2006/07/060709125148. Probiotic/Prebiotic, Complete-B Vitamins, Omega-3 Fatty Acids, Homocysteine inherently perilous without Betaine, Folate, htm. 5-Aminoimidazole-4- Whole Food Organic Vitamins, Complete Minerals, at lower level anti-inflammatory Methionine, carboxamide-1-β-d- Flavonoid/Carotenoid/Phytochemical Supplement, Glandular Mix, thresholds accompaniment, PEMT Glutathione, Ribofuranoside inhibits KAL SOD3 or other Antioxidant Mix with Catalase and Superoxide describe regulates itself out of Cysteine, Phosphatidylethanolamine Dismutase, Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, outcomes necessity, ancillary sources Methyltetradydr Methyltransferase although Inhibitors of AP-1(x), including Citrus Fruit with Peelings/Rinds, among younger of Homocysteine can be ofolate the literature does not Inhibitors of SP-1(X), Management of Homocysteine, Management of populations but perilous, the few pathways of availability are suggest that PEMT is a S-Adenosyl Homocysteine or S-Adenosyl Homocysteine inhibitors, include its depletion may be essential primary ways of contributor to Pathogenic inhibitors of Inducible Nitric Oxide Synthase, Inhibitors of Uncouple Behavioral, to health and therapeutic managing Homocysteine Levels, Nitric Oxide Synthase and its Reactive Molecular Species (L-Arginine, Biophysiologic objectives of 6 Micromoles Homocysteine. particularly since it is self- Tetrahydrobiopterin, NADPH, Superoxide Dismutase, Catalase, al and more per liter may be conservative, Catecholamines, regulated through Glutathione, Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, Behaviorally while optimal may be closer Bioflavonoids, Homocysteine and Complete B-Vitamins with B-12 Methylcobalamin, Uridine, integrative and to less than four or less than Tea Catechins particularly since impaired Prebiotic/Probiotic to Manage Inflammation Factors Produced during lifestyle 2. Homocysteine Assay inhibit PEMT is correlated with Ingestion of some Choline Dense Foods, Enzymes which metabolize integrative Details. Homocysteine increased levels of these factors or synthesize these factors as well as precursors to these outcomes. www.cdc.gov/nchs/data/nhan from COMT. Homocysteine. Studies factors, Water, Phosphatidyl-Monomethylethanolamine es/nhanes_03_04/l06_c_met_ clearly show the level of (Phosphatidylmonomethylethanolamine or PMME), Human Rubisco, homocysteine.pdf PEMT activity is inversely Recombinant Rubisco, Rubisco Agonists or Rubisco Modulators, www.questdiagnostics.com/t correlated with Polyacetylates, Phosphatidylethanolamine, Phosphatidylethanolamine estcenter/BUOrderInfo.actio Homocysteine Levels. Methyltransferase, Methyltetrahydrofolate Reductase, Betaine n?tc=31789&labCode=AMD Journal of Nutrition, Volume Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt 100 tests for $549.00 136, Number 12, Pages 3005 instead of Table Salt. Cobalamin and AdenosylCobalamin. www.eaglebio.com/homocyst to 3009, December 2006. eine-hplc-assay-kit/ Factor Indicative Information Wholistic Factors to Accompany Therapeutics Information S-Adenosyl S-Adenosyl Management of Phospholipid/Choline Choline, Trimethylglycine, Folate/Methylfolate, Glutathione, Homocysteine Homocysteine Pathways, Inhibitors or modulator of S- Probiotic/Prebiotic, Complete-B Vitamins, Omega-3 Fatty Specific Test. Adenosyl Homocysteine and S-Adenosyl Acids, Whole Food Organic Vitamins, Complete Minerals, The pathogenic www.eaglebio.c Homocysteine Hydrolase. R-(+)- or S-(-)- Flavonoid/Carotenoid/Phytochemical Supplement, Glandular Nature of S- om/content/SAH nicotine enantiomers decrease S-Adenosyl Mix, KAL SOD3 or other Antioxidant Mix with Catalase and Adenosyl 31- Homocysteine 60-Fold as well as reduces Superoxide Dismutase, Choline Kinase Inhibitors, Tyrosine Homocysteine K01_S_Adenosy Homocysteine by 15 Fold, but this Kinase Inhibitors, Inhibitors of AP-1(x), including Citrus Fruit Compared to l_L_Homocystei suggests that both PEMT inhibition may be with Peelings/Rinds, Inhibitors of SP-1(X), Management of Homocysteine ne_SAH_ELISA occurring. R-(+)- or S-(-)-nicotine 9-Fold Homocysteine, Management of S-Adenosyl Homocysteine or S- generally, _Assay_Kit.pdf and 15-Fold reduction in S-Adenosyl Adenosyl Homocysteine inhibitors, inhibitors of Inducible particularly when $1,330.00 for 96 Methionine respectively. PEMT function Nitric Oxide Synthase, Inhibitors of Uncouple Nitric Oxide S-Adenosyl Assay Kits. decreases S-Adenosyl Homocysteine and Synthase and its Reactive Molecular Species (L-Arginine, Homocysteine is decreases Homocysteine. This suggest. Tetrahydrobiopterin, NADPH, Superoxide Dismutase, Catalase, increased compared Clearly, a direct invoking of a Pathogenic Glutathione, Citrulline/Arginine/Ornithine), NAD+, to Homocysteine influence to PEMT by Nicotine which every Hyaluronic Acid, Complete B-Vitamins with B-12 otherwise is Pathology also invokes either directly or Methylcobalamin, Uridine, Prebiotic/Probiotic to Manage described by the indirectly. PMID 3715913. Methionine Inflammation Factors Produced during Ingestion of some Literature as being supplementation increases Homocysteine, Choline Dense Foods, Enzymes which metabolize these factors enhanced. suggesting the PEMT function may be or synthesize these factors as well as precursors to these factors, essential during Methionine availability Water, Phosphatidyl-Monomethylethanolamine because alternative sources of (Phosphatidylmonomethylethanolamine or PMME), Human Homocysteine may utilize S-Adenosyl Rubisco, Recombinant Rubisco, Rubisco Agonists or Rubisco Methionine without an inhibitor Influence. Modulators, Polyacetylates, Phosphatidylethanolamine, Phosphatidylethanolamine Methyltransferase, Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table Salt. Factor Indicative Information Wholistic Factors to Accompany Therapeutics Information S-Adenosyl S-Adenosyl Specifically, although Folate may be presumed to Choline, Trimethylglycine, Folate/Methylfolate, Glutathione, Homocysteine Homocysteine assist in Homocysteine depletion and it is present in Probiotic/Prebiotic, Complete-B Vitamins, Omega-3 Fatty Acids, Specific Test. cellular entities generally, Folate cannot replace Whole Food Organic Vitamins, Complete Minerals, The best study of www.eaglebio.com Choline and PEMT as source of sustain methionine Flavonoid/Carotenoid/Phytochemical Supplement, Glandular Mix, a 500 to 1 /content/SAH31- availability, while Choline enables the synthesis of KAL SOD3 or other Antioxidant Mix with Catalase and Superoxide decrease in K01_S_Adenosyl_ Betaine which BHMT uses to deplete Homocysteine. Dismutase, Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, demise from L_Homocysteine_ Choline is also known to increase PEMT although Inhibitors of AP-1(x), including Citrus Fruit with Peelings/Rinds, Homocysteine at SAH_ELISA_Assa assuring inhibition of AP-1, SP-1, and Thrombin Inhibitors of SP-1(X), Management of Homocysteine, Management less than 7 y_Kit.pdf seem to be priorities in assuring PEMT also. S- of S-Adenosyl Homocysteine or S-Adenosyl Homocysteine Micromoles per $1,330.00 for 96 Adenosyl Homocysteine Hydrolase is inhibited by 3- inhibitors, inhibitors of Inducible Nitric Oxide Synthase, Inhibitors of liter cannot be Assay Kits. Deazaneplanocin A (DZNep). DOI Uncouple Nitric Oxide Synthase and its Reactive Molecular Species utilized since the 10.1016/j.bbrc.2013.07.128. Aristeromycin-5‘- (L-Arginine, Tetrahydrobiopterin, NADPH, Superoxide Dismutase, only statistic carboxaldehyde inhibits S-Adenosyl Homocysteine Catalase, Glutathione, Citrulline/Arginine/Ornithine), NAD+, instance of Hydrolase. DOI 10.1021/jm950916u. There are Hyaluronic Acid, Complete B-Vitamins with B-12 Methylcobalamin, demise occurs in numerous inhibitors of S-Adenosyl Homocysteine Uridine, Prebiotic/Probiotic to Manage Inflammation Factors the Tenth or Hydrolase which are emerging as strong antiviral Produced during Ingestion of some Choline Dense Foods, Enzymes concluding factors. DOI 10.1016/j.bmc.2009.07.061. The which metabolize these factors or synthesize these factors as well as annum. Resulting availability of S-Adenosyl Homocysteine Hydrolase precursors to these factors, Water, Phosphatidyl- in 0 instances of for any directional processing of S-Adenosyl Monomethylethanolamine (Phosphatidylmonomethylethanolamine demise compared Homocysteine or Homocysteine decreases with the or PMME), Human Rubisco, Recombinant Rubisco, Rubisco to 500 in the availability of any of its Products/Substrates. Folate Agonists or Rubisco Modulators, Polyacetylates, Tenth Annum and Betaine unavailability, then, can constrain Phosphatidylethanolamine, Phosphatidylethanolamine with any manner Genetic Transcription to accompany an Methyltransferase, Methyltetrahydrofolate Reductase, Betaine of improvement. apportionment of Genetic Transcription to Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt Inflammation Factor Synthesis additionally instead of Table Salt. impairing S-Adenosyl Hydrolase Activity. Factor Indicative Information Wholistic Factors to Accompany Therapeutics

Choline Homocysteine unequal to Choline CPT Code Lipid Panel CPT Code 80061. Choline, Trimethylglycine, Folate/Methylfolate, Glutathione, Pathway Above 7 for Clinical www.causenta.com/our-testing/ Probiotic/Prebiotic, Complete-B Vitamins, Omega-3 Fatty Inadequacy. Pathology and above 1 www.sigmaaldrich.com/catalog/product/sigma/mak056?lang Acids, Whole Food Organic Vitamins, Complete Minerals, Lipid Panel, Micromole per liter for =en®ion=US 100 Diagnostic Tests for $429.50, 50 Flavonoid/Carotenoid/Phytochemical Supplement, Glandular Choline. subclinical pathology. Choline and 50 Acetylcholine. Mix, KAL SOD3 or other Antioxidant Mix with Catalase and Choline is typically about . Choline Diagnostic Assay. Superoxide Dismutase, Choline Kinase Inhibitors, Tyrosine 27 Micromoles Per Liter www.aatbio.com/resources/catalog/BQAP.pdf $195 per Kinase Inhibitors, Inhibitors of AP-1(x), including Citrus Fruit at Birth, 6.8 for Adult individual Kit. Consider Bulk Purchase. with Peelings/Rinds, Inhibitors of SP-1(X), Management of Female and 6.0 for Males. Choline/Acetylcholine Diagnostic Assay Homocysteine, Management of S-Adenosyl Homocysteine or S- The University of North hwww.abcam.com/CholineAcetylcholine-Assay-Kit- Adenosyl Homocysteine inhibitors, inhibitors of Inducible Carolina at Chapel Hill ab65345.html Nitric Oxide Synthase, Inhibitors of Uncouple Nitric Oxide suggests 550 Milligrams a Choline, Folate, Betaine or Trimethylglycine, Synthase and its Reactive Molecular Species (L-Arginine, Day as a minimum Lysophosphatidycholine, Phosphatidylcholine, factors which Tetrahydrobiopterin, NADPH, Superoxide Dismutase, Catalase, ingestion level while the downregulate Inhibitors of PEMT, Choline Kinase inhibitors Glutathione, Citrulline/Arginine/Ornithine), NAD+, Hyaluronic FDA suggest 425 as an which prevent Phosphorylation of Free Choline, Acetyl-CoA Acid, Complete B-Vitamins with B-12 Methylcobalamin, alternate Minimum for which enables Acetylcholine Synthesis from Free Choline, Uridine, Prebiotic/Probiotic to Manage Inflammation Factors Women Specifically and PEMT which enables de novo Synthesis of Produced during Ingestion of some Choline Dense Foods, 550 MG for Men. 7500 Phosphatidylcholine, Recombinant PEMT, Enzymes which metabolize these factors or synthesize these MG ingestion is suggested Phosphatidylethanolamine, 17 Beta Estradiol, Pregnenolone. factors as well as precursors to these factors, Water, as the highest level of Acetyl-CoA increases potential for Choline to be become Phosphatidyl-Monomethylethanolamine ingestion and 3500 as Acetylcholine compared to Choline Kinase Upregulation (Phosphatidylmonomethylethanolamine or PMME), Human tolerable upper limit by which transforms Free Choline into Phosphocholine. Causes Rubisco, Recombinant Rubisco, Rubisco Agonists or Rubisco Linus Pauling Instituted at upregulation of Choline Kinase and Phosphocholine Modulators, Polyacetylates, Phosphatidylethanolamine, the University of Oregon. synthesis resulting in overactive cellular survival signaling, Phosphatidylethanolamine Methyltransferase, hyperactivation of complements Immune Systems, is a Methyltetrahydrofolate Reductase, Betaine Homocysteine constitutive aspect of Platelet Activating Factor, accumulates Methyltransferase, Ancient Pink Himalayan Sea Salt instead of on cellular interfaces to cause, increases C-Reactive Protein, Table Salt. cause immune response, independently activates Platelets to Stroke, vascular deterioration, and cirvument Tissue Plasminogen Activator as well as circumvents Platelet Activation Factor inhibitors like Clopidogrel. Factor Indicative Information Wholistic Factors to Accompany Therapeutics

PEMT Impairment. Choline Diagnostic Analytically Significant Ranges Exhibited by Healthiest Patients Observed in Choline, Trimethylglycine, Folate/Methylfolate, Impairment Assay. Practice. Poiglitazone prevents inflammation and hepatic detriment when Glutathione, Probiotic/Prebiotic, Complete-B Oncology Gene www.aatbio.com/resources/catalog PEMT is genetically or functionally impaired. DOI 10.1152/ajpgi.00243.2015 Vitamins, Omega-3 Fatty Acids, Whole Food Expression /BQAP.pdf 96 Tests for $710.00 www.mybiosource.com/prods/ELISA- Organic Vitamins, Complete Minerals, Kit/Human/phosphatidylethanolamine-N- Flavonoid/Carotenoid/Phytochemical Supplement, Choline/Acetylcholine Diagnostic methyltransferase/PEMT/datasheet.php?products_id=924990 Glandular Mix, KAL SOD3 or other Antioxidant Assay Gold is among the Divalent Metal Ions which can enable PEMT function. Mix with Catalase and Superoxide Dismutase, hwww.abcam.com/CholineAcetylc DOI: 10.1038/nchem.2836 . Myrrh and Frankincense inhibit Cyclooxygenase Choline Kinase Inhibitors, Tyrosine Kinase holine-Assay-Kit-ab65345.html. , CFOS and CJUN, thereby also inhibiting AP1 and SP1. DOI Inhibitors, Inhibitors of AP-1(x), including Citrus PEMT can be inhibited by 10.1038/srep13668 Fruit with Peelings/Rinds, Inhibitors of SP-1(X), Estrogen Receptor Inhibitors . PEMT, 17beta-Estradiol, Pregnenolone, Testosterone, S-Adenosyl Management of Homocysteine, Management of S- although it is not recommended by Methionine, S-Adenosyl Homocysteine Inhibitor, BHMT, Adenosyl Homocysteine or S-Adenosyl these analysis to conduct such Phosphatidylethanolamine, AP-1 Inhibitor, SP1 Inhibitor, Choline Kinase Homocysteine inhibitors, inhibitors of Inducible activity or at least not for any Inhibitor. Studies clearly show the level of PEMT activity is inversely Nitric Oxide Synthase, Inhibitors of Uncouple more than very short duration in correlated with Homocysteine Levels. Journal of Nutrition, Volume 136, Nitric Oxide Synthase and its Reactive Molecular specific tissues or specific cellular Number 12, Pages 3005 to 3009, December 2006. Managing Homocysteine, Species (L-Arginine, Tetrahydrobiopterin, entities. 10.1074/jbc.M110.109843 while inhibiting AP-1, SP-1, iNOS, Thrombin, and other factors assure PEMT NADPH, Superoxide Dismutase, Catalase, . function. Cuties, Food Oils such as Olive Oil, Sugar Beets, Whole Wheat, Glutathione, Citrulline/Arginine/Ornithine), Meat, Chicken, Eggs, Fish, or foods within increased levels of Choline, NAD+, Hyaluronic Acid, Complete B-Vitamins Betaine and Folate all can enhance the function of PEMT, although managing with B-12 Methylcobalamin, Uridine, inhibitors of PEMT can enable these to be more effective. Causes upregulation Prebiotic/Probiotic to Manage Inflammation of Choline Kinase and Phosphocholine synthesis resulting in overactive Factors Produced during Ingestion of some cellular survival signaling, hyperactivation of complements Immune Systems, Choline Dense Foods, Enzymes which metabolize is a constitutive aspect of Platelet Activating Factor, accumulates on cellular these factors or synthesize these factors as well as interfaces to cause, increases C-Reactive Protein, cause immune response, precursors to these factors, Water, Phosphatidyl- independently activates Platelets to Stroke, vascular deterioration, and Monomethylethanolamine cirvument Tissue Plasminogen Activator as well as circumvents Platelet (Phosphatidylmonomethylethanolamine or Activation Factor inhibitors like Clopidogrel. PMME), Human Rubisco, Recombinant Rubisco, Rubisco Agonists or Rubisco Modulators, Polyacetylates, Phosphatidylethanolamine, Phosphatidylethanolamine Methyltransferase, Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table Salt. Factor Indicative Information Information Wholistic Factors to Accompany Therapeutics

Arachidonic The principal Pathway to Aspirin inhibits Arachidonic Acid The Imidazole derivatives Choline, Trimethylglycine, Folate/Methylfolate, Acid. Inflammation, Leukotrienes, Metabolism by inhibiting both ketoconazole, clotrimazole, Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, Prostaglandins, COX and LOX. PMID 6812163 Nordihydroguaiaretic acid Omega-3 Fatty Acids, Whole Food Organic Vitamins, Thromboxanes and Reactive Rye Pollen Extract. (NDGA), Eicosatetranoic Complete Minerals, Flavonoid/Carotenoid/Phytochemical Oxygen Species of an www.graminex.com/graminex/file/ acid (ETYA), and Supplement, Glandular Mix, KAL SOD3 or other Inflammatory nature. 150 49_inhibition_of_the_arachidonic_ indomethacin inhibit Antioxidant Mix with Catalase and Superoxide Dismutase, test for an unknown amount. acid_metabolism_by_an_extract_fr Arachidonic Acid’s Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, www.progen.com/products/ om_rye_pollen.pdf. 10 tests for transformation into Inhibitors of AP-1(sx), including Citrus Fruit with diagnostic- an unknown amount www.gta- Eicosanoids or Peelings/Rinds, Inhibitors of SP-1(X), Management of assays/coagulation/arachido uk.co.uk/app/download/578258631 Inflammatory Factors. DOI Homocysteine, Management of S-Adenosyl Homocysteine nic-acid-50mm.html. 0/Plateletworks+Arachidonic+Acid 10.1016/0003- or S-Adenosyl Homocysteine inhibitors, inhibitors of Commercial literature +Data+Sheet.pdf Lifocelone and 9861(88)90340-2. Omega-3 Inducible Nitric Oxide Synthase, Inhibitors of Uncouple suggests typical when = or < NSAIDS inhibit Arachidonic Acid. Fatty Acids, DHA, EPA, Nitric Oxide Synthase and its Reactive Molecular Species 0.2 Micromoles per liter. www.onlinelibrary.wiley.com/doi/1 Gamma-Linoleic Acid, (L-Arginine, Tetrahydrobiopterin, NADPH, Superoxide www,pdl.testcatalog.org/sho 0.1111/bcpt.12134/full Vitamin E, Vitamin C, Dismutase, Catalase, Glutathione, w/OMEG36 Ascidiathiazone as alkaloid inhibits Polyphenols, Flavonoids, St Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, www.progen.com/products/ Neutrophil activity. Cembranolides Johns Wort, Rosemary, Complete B-Vitamins with B-12 Methylcobalamin, diagnostic- inhibit COX-2. Durumolides inhibit Curcumin, Cats Claw. Uridine, Prebiotic/Probiotic to Manage Inflammation assays/coagulation/arachido iNOS and COX – 2. Frajunolides as Khalsa Chiropractric Factors Produced during Ingestion of some Choline Dense nic-acid-50mm.html. Diterpenoids inhibit Neutrophil Website. Plakortide P, as a Foods, Enzymes which metabolize these factors or Commercial literature activity. Manzamine, as alkaloids, Polyketide, is an synthesize these factors as well as precursors to these suggests typical when = or < inhibit Thromboxane B2. Antineuroinflammatory factors, Water, Phosphatidyl-Monomethylethanolamine 0.2 Micromoles per liter. Cateramine A, as an Alkaloid, factor. Rubrolide O as (Phosphatidylmonomethylethanolamine or PMME), Human www,pdl.testcatalog.org/sho inhibits Neutrophil Chemotactic Halogenated Furanone Rubisco, Recombinant Rubisco, Rubisco Agonists or w/OMEG36 Activity. inhibits Neutrophil activity. Rubisco Modulators, Polyacetylates, DOI 10.1155/2013/572859 Phosphatidylethanolamine, Phosphatidylethanolamine Methyltransferase, Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table Salt. Factor Indicative Information Information Wholistic Factors to Accompany Therapeutics

Viral DNA Vistide or HPMPC is known to Natural Viral DNA Polymerase Inhibitors. Diverse Choline, Trimethylglycine, Folate/Methylfolate, and Viral be effective in managing viral Polyphenols, Bioflavanoids, including extract of Phy Niruri, Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, RNA DNA polymerases. extract of Phy. Amarus, Phy. Urinaria, licorice root Omega-3 Fatty Acids, Whole Food Organic Vitamins, Polymerase Glycyrhiza glabra, Rosemarinic acid, Caffeic Acid, eugeniin Complete Minerals, Flavonoid/Carotenoid/Phytochemical A Blend of Phytochemicals, (ellagitannin) extracted from Geum japonicum and eugeniin Supplement, Glandular Mix, KAL SOD3 or other flavonoids, polyines, thiophenes, (ellagitannin) extracted from Syzygium aromaticum, Antioxidant Mix with Catalase and Superoxide Dismutase, proteins and peptides in such triterpene acids of Geum japonicum such as Ursolic acid and Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, regard. terpenoids, lignans, Maslinic acid, the Triterpene Moronic Acid, extract of Rhus Inhibitors of AP-1(sx), including Citrus Fruit with sulphides, polyphenolics, javanica, Geranium sanguineum (L.), lignans isolated from Peelings/Rinds, Inhibitors of SP-1(X), Management of coumarins, saponins, furyl Larrea tridentates as well as from Rhinacanthus nasutus and Homocysteine, Management of S-Adenosyl Homocysteine compounds, alkaloids, as well as Kadsura matsudai, Calophyllum inophyllum, Cal. lanigerum, or S-Adenosyl Homocysteine inhibitors, inhibitors of cooking herbs, culinary herbs and Cal. teysmannii latex and Cal. cerasiferum, Morin is from Inducible Nitric Oxide Synthase, Inhibitors of Uncouple oils used for flavoring food, Maclura cochinchinensis, extracts from Rhus succedanea and Nitric Oxide Synthase and its Reactive Molecular Species provides a variety of Viral DNA Garcinia multiflora (amentoflavone, agathisflavone, (L-Arginine, Tetrahydrobiopterin, NADPH, Superoxide Polymerase and Viral RNA robustaflavone, rhusflavanone and succedaneflavanone) Dismutase, Catalase, Glutathione, Inhibition. Flavonol Iridoid glycosides and phenylpropanoid glycosides Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, (uteoside A, luteoside B and luteoside C) from Barleria Complete B-Vitamins with B-12 Methylcobalamin, Favipiravir is an inhibitor of prionitis and from the roots of Markhamia lutea, Dianella Uridine, Prebiotic/Probiotic to Manage Inflammation Diverse Viral RNA including longifolia which exhibits Flavanoid Chrysosplenol C and Factors Produced during Ingestion of some Choline Dense RNA viruses considered to be Pterocaulon sphacelatum which exhibits the Anthraquinone Foods, Enzymes which metabolize these factors or untreatable otherwise. United Chrysophanic Acid, Theaflavin from Black Tea, Diverse synthesize these factors as well as precursors to these States National Library of fruits, vegetables, tea, grains, bark, roots, stems and flowers, factors, Water, Phosphatidyl-Monomethylethanolamine Medicine PMID 28769016. Viral which are edible and considerably nontoxic. Digital (Phosphatidylmonomethylethanolamine or PMME), Human RNA Polymerase inhibitors are Objective Identifier Rubisco, Recombinant Rubisco, Rubisco Agonists or presented at this digital objective 10.1046/j.1365-2672.2003.02026.x provides specific Rubisco Modulators, Polyacetylates, Identifier. information about Viral Specific Phytochemicals. Phosphatidylethanolamine, Phosphatidylethanolamine Digital Object Identifier 10.1046/j.1365-2672.2003.02026.x Methyltransferase, Methyltetrahydrofolate Reductase, NLS-RIG-I is know to destabilize presents DNA Polymerase inhibitor therapeutics. Betaine Homocysteine Methyltransferase, Ancient Pink the CV Membranous Web and Himalayan Sea Salt instead of Table Salt. inhibit HCV Replication. Factor Indicative Information Information Wholistic Factors to Accompany Therapeutics

Viral DNA Cynaropicrin inhibits iNOS, CD29, CD98, as well as cellular surface CD29 and CD147, while its Choline, Trimethylglycine, Folate/Methylfolate, and Viral mechanisms of action seems to be through inhibition of Extracellular Signal Associated Kinase Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, RNA ERK such that it may be a potent therapy for conditions involving Cytoskeleton rearrangements. Omega-3 Fatty Acids, Whole Food Organic Vitamins, Polymerase A study exhibits that Amyloid Beta (versions between 40 and 1) administration could have its Complete Minerals, Flavonoid/Carotenoid/Phytochemical detrimental effects inhibited through inhibition of TNF-Alpha or inhibition of Inducible Nitric Supplement, Glandular Mix, KAL SOD3 or other Oxide Synthase, suggesting that TNF-alpha and iNOS cyclically potentiate one another. Antioxidant Mix with Catalase and Superoxide Dismutase, Silymarin/Silibinin with IC50s between 100 and 40 Micromoles per Liter, inhibits Viral entry, Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, Fusion, Replication, RNA/Protein Synthesis, Viral Particle Secretion and intercellular transport of Inhibitors of AP-1(sx), including Citrus Fruit with Viral Proteins through NS5B Inhibition. EGCG from Camellia Sinensis, with IC50s between 21 Peelings/Rinds, Inhibitors of SP-1(X), Management of and 5 Micromoles per Liter, inhibits Early Viral Entry Glycoprotein Viral Adhesion, intercellular Homocysteine, Management of S-Adenosyl Homocysteine transport, replication and affects supernatant clearance through inhibiting Virion, RNA, NS3 or S-Adenosyl Homocysteine inhibitors, inhibitors of Protease, and NS5A. Ladanein – BJ486K from Marrubium Peregrinum L, with IC50s between 10 Inducible Nitric Oxide Synthase, Inhibitors of Uncouple and 2.5 Micromoles per Liter, inhibits Viral Entry. Naringenin from Grapefruit, particularly Nitric Oxide Synthase and its Reactive Molecular Species peelings, inhibits Viral Assembly and Secrection of Viral Particles as well as Secretion of HCV (L-Arginine, Tetrahydrobiopterin, NADPH, Superoxide RNA. Quercetin from Embelia Ribes inhibits IRES Translation and inhbits NS5A Protein, Viral Dismutase, Catalase, Glutathione, Replication and Viral Production through inhibition of NS3 Protease. Luteoloin – Apigenin, with Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, IC50s between 7.9 and 1.1 micromoles Per Liter, inhibits HCV pathology and replication by Complete B-Vitamins with B-12 Methylcobalamin, inhibiting NS5B Polymerase. Honokiol from Magnolia Grandiflora, with IC50s of 4.5 Micromoles Uridine, Prebiotic/Probiotic to Manage Inflammation Per Liter inhibits Viral Entry and Replication through downregulation of NS3 Protease, NS5A, and Factors Produced during Ingestion of some Choline Dense NS5B. 3-Hydroxy Caruilignan C from Swietenia Macrophylla, with IC50s of 37.5, inhibits Viral Foods, Enzymes which metabolize these factors or RNA, and NS3 Protease. Exoecariphenol D Coilagin from Exoecaria Agallocha L, with IC50S synthesize these factors as well as precursors to these between 13.5 and12.6 Micromoles per Liter, inhibits Viral Replication through inhibition of NS3 factors, Water, Phosphatidyl-Monomethylethanolamine Protease. These factors have been effective in inhibiting HCV along with Polyphenols (Phosphatidylmonomethylethanolamine or PMME), Human 3’,4’,5,6,7,8 M Hexamethoxyflavone or Nobilietin from Citrus Unshiu Peel Aurantii Nobilis Rubisco, Recombinant Rubisco, Rubisco Agonists or Pericarpium, Oligophenolic SCH 644343 and SCH 644342 from Peruvian Stylogne Cauliflora, Rubisco Modulators, Polyacetylates, 1,2,3,4,6 Penta-O-Galloyl-B-D-Glucoside from Saxifraga Melanocentra Franch, Polyphenols Phosphatidylethanolamine, Phosphatidylethanolamine 1,2,5-tri-O-galloyl-Beta-D-Glucose, 1,2,4,6-tetra-0-galloyl-Beta-D-glucose, and 1,2,3,4,6-Penta-O- Methyltransferase, Methyltetrahydrofolate Reductase, Galloyl-Beta-D-Glucose from Ethyl Acetate of Galla, as well as excoecariphenol D and Corilagin Betaine Homocysteine Methyltransferase, Ancient Pink from Excoecaria Agallocha L (Euphorbiaceae) the Mangrove Plant. Himalayan Sea Salt instead of Table Salt. Factor Indicative Information Information Wholistic Factors to Accompany Therapeutics Uncoupled The literature suggests Citrulline is produced in direct Angiotensin Converting Choline, Trimethylglycine, Folate/Methylfolate, Nitric Oxide that Citrulline levels are correlation to Nitric Oxide which Enzymes, Statins, AT1 Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, Synthase. indicative of Nitric can occur in mixed levels with Receptor Inhibitors, Omega-3 Fatty Acids, Whole Food Organic Vitamins, Oxide Synthase Activity Superoxide as Nitric Oxide Resveratrol and Nebivolol Complete Minerals, Flavonoid/Carotenoid/Phytochemical Nitrosamine, particularly when Synthase becomes uncoupled and exhibit inhibition of Uncoupled Supplement, Glandular Mix, KAL SOD3 or other Nitrosamide compared to other coupled as substrate availability NOS.DOI Antioxidant Mix with Catalase and Superoxide Dismutase, and Morpholine Oxidative Distress changes. Management of ONOO- 10.1016/j.coph.2013.01.006 Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, cause indicators. or Peroxynitrite such as Carbon Tetrahydrobiopterin is Inhibitors of AP-1(x), including Citrus Fruit with expression of Levels of Peroxynitrite Dioxide, Thiols Ascorbate, presented in some literature as Peelings/Rinds, Inhibitors of SP-1(X), Management of iNOS, NFKB were a median 4.47 with Synthetic Metalloporphyrins, Cofactor for Endothelial Nitric Homocysteine, Management of S-Adenosyl Homocysteine and AP1 while range of + and - 0.38 in Selenocompounds, Particular Oxide Synthase. DOI or S-Adenosyl Homocysteine inhibitors, inhibitors of Nitrosating Healthy controls Peroxidases, Albumin, 10.1152/ajpheart.01315.2010 Inducible Nitric Oxide Synthase, Inhibitors of Uncouple many factors whereas 7.23 with a Selenoproteins and Hemoglobin. Superoxide seems to be the Nitric Oxide Synthase and its Reactive Molecular Species including range of + and - 0.92 Scavengers of Peroxynitrite can best indicator here as do (L-Arginine, Tetrahydrobiopterin, NADPH, Superoxide Tyrosine. was exhibited in Patients include 2 - Phenyl - 1, Selenium reactive Oxygen Species or Dismutase, Catalase, Glutathione, with Lupus using compounds, 2 Benzisolenazol – 3 Reactive Molecular Species Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, D-Roms Test Micromoles Per Liter in (2H) – One or Ebselen, generally. There is a Complete B-Vitamins with B-12 Methylcobalamin, Uridine, may be useful. Blood. Peroxynitrite is Selenocysteine, possibility that excessive Prebiotic/Probiotic to Manage Inflammation Factors suggested as ubiquitous Selenomethionine, Glutathione Neopterin from Cellular Produced during Ingestion of some Choline Dense Foods, SuperWater by oxidation factor Peroxidase and Thioredoxin Immune response, such as with Enzymes which metabolize these factors or synthesize these Bodyarmour affecting BH4, Uric Acid Reductase, Epicatechin, Phosphocholine accumulation factors as well as precursors to these factors, Water, can help and other factors. Flavonoids, 5,10,15,20- which actives Complements Phosphatidyl-Monomethylethanolamine manage Reference Arch Biochem tetrakis(4-sulfonatophenyl) Immunological System and C (Phosphatidylmonomethylethanolamine or PMME), Human Nitrosamine Biophys, Volume 372, porphyrinato iron III chloride Reactive Protein, can depleted Rubisco, Recombinant Rubisco, Rubisco Agonists or Levels. Number 2, Pages 285 to (FeTTPs), and Uric Acid from Tetrahydrobiopterin. The Rubisco Modulators, Polyacetylates, 294. Peroxynitrite Purine Synthesis. Bodyarmour Bioflavonoid Complex Phosphatidylethanolamine, Phosphatidylethanolamine inhibits eNOS and Superwater with Potassium Kolaviron from Garcinia Kola Methyltransferase, Methyltetrahydrofolate Reductase, Prostacylcin Synthase, Bicarbonate can be used to seed Extract can prevent Betaine Homocysteine Methyltransferase, Ancient Pink antagonizes managed Peroxynitrate produced detriment from Nitrosamines, Himalayan Sea Salt instead of Table Salt. Thromboxane Synthase from Nitrosamine as well as Nitrosamide and potentially A2 inhibiting managed Nitrosamine. Morphaline. Vasodilation. Factor Indicative Information Information Wholistic Factors to Accompany Therapeutics Uncoupled Nitric www.ncbi.nlm.nih.gov/ S-nitrosoglutathione (GSNO) manages Peroxynitrite indicative of uNOS. Choline, Trimethylglycine, Folate/Methylfolate, Oxide Synthase. pubmed/10424368?acce Therapeutics factors include Citrulline, Watermelon, Dark Cocoa, Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, www.depts.washin ss_num=10424368&lin Pomegranate, Walnuts, Spinach, Oranges, Beets, Cranberries, Garlic, Black Omega-3 Fatty Acids, Whole Food Organic Vitamins, gton.edu/androl/pr k_type=MED&dopt=A Tea, Cayenne, Pepper, Pistachios, Honey, Salmon, Kale, Animal Organs, Complete Minerals, ices.html bstract. Reactive Onions, Shrimp. Boydr www.amrapnutrition.com/interesting_other/fuel- Flavonoid/Carotenoid/Phytochemical Supplement, Oxygen Species test performance-18-foods-nitric-oxide-production/ Uretic Output can be Glandular Mix, KAL SOD3 or other Antioxidant Mix Uncoupled Nitric www.tools.thermofisher visually reviewed to determine its Hue. Lipid peroxidation info at with Catalase and Superoxide Dismutase, Choline Oxide Synthase .com/content/sfs/manua www.biotek.com/resources/white-papers/an-introduction-to-reactive-oxygen- Kinase Inhibitors, Tyrosine Kinase Inhibitors, Inhibitors produces ls/88-5930.pdf 200 species-measurement-of-ros-in-cells/ Urine Specific Gravity, particularly of AP-1(x), including Citrus Fruit with Peelings/Rinds, Peroxynitrites Tests for $249.00 considering Peroxynitrite or Nitrites is indicative of Uncoupled Nitric Oxide Inhibitors of SP-1(X), Management of Homocysteine, which can www.thermofisher.com/ Synthase. The clarity of Urine is correlated to decreases Reactive Nitrogen Management of S-Adenosyl Homocysteine or S- Nitrosate order/catalog/product/8 or Peroxynitrites, whereas diminished clarity indicates that reactive molecular Adenosyl Homocysteine inhibitors, inhibitors of Nitrosamine, 8-5930-74?SID=srch- species are increased. L-arginine, Tetrahydrobiopterin, NADPH, Superoxide Inducible Nitric Oxide Synthase, Inhibitors of Uncouple Nitrosamide and srp-88-5930-74 Dismutase, Catalase, Glutathione, Vanadium, L-Ornithine and L-Citrulline in Nitric Oxide Synthase and its Reactive Molecular Morpholine Hydroxyl/Peroxynitrite Equal Amounts, Flavin Adenine Dinucleotide, Flavin Mononucleotide, Species (L-Arginine, Tetrahydrobiopterin, NADPH, Precursors. Diagnostic Assay, 150 HEME, Iron, Ca2+, Calmodulin, O2, H+. Sapriopterin as Kuvan the Superoxide Dismutase, Catalase, Glutathione, Tests for $175. Pharmacological Factor. Managing any of the principle Super Indicators Citrulline/Arginine/Ornithine), NAD+, Hyaluronic www.biokits.com/produ Presented here, particularly those which are Primary stimulators of Inducible Acid, Complete B-Vitamins with B-12 ctinfo/3862/Hydroxyl- Nitric Oxide Synthase. Article on Uncoupled Nitric Oxide Synthase and its Methylcobalamin, Uridine, Prebiotic/Probiotic to Peroxynitrite-Detection- Pharmacological Therapeutic Reversal. DOI 10.1016/B978-0-12-373866- Manage Inflammation Factors Produced during Kit.html 0.00005-8 NADPH Oxidase can enhance Uncoupled Nitric Oxide Synthase Ingestion of some Choline Dense Foods, Enzymes Tetrahydrobiopterin, and is inhibited by the Xanthine Oxidase inhibitor Allopurinol. which metabolize these factors or synthesize these supplemented at 400 L-arginine, Tetrahydrobiopterin, NADPH, Superoxide Dismutase, Catalase, factors as well as precursors to these factors, Water, MG per day, has been Glutathione, Vanadium, L-Ornithine / L-Citrulline in Equal Amounts, Flavin Phosphatidyl-Monomethylethanolamine shown to substantially Adenine Dinucleotide, Flavin Mononucleotide, HEME, Iron, Ca2+, (Phosphatidylmonomethylethanolamine or PMME), and stably improve Calmodulin, O2, H+. Sapriopterin as Kuvan the Pharmacological Factor. Human Rubisco, Recombinant Rubisco, Rubisco Blood Pressure and Managing any of the principle Super Indicators Presented here, particularly Agonists or Rubisco Modulators, Polyacetylates, improve endothelial those which are Primary stimulators of Inducible Nitric Oxide Synthase. Phosphatidylethanolamine, Phosphatidylethanolamine Function in Article on Uncoupled Nitric Oxide Synthase and its Pharmacological Methyltransferase, Methyltetrahydrofolate Reductase, Hypertensive subjects. Therapeutic Reversal. DOI 10.1016/B978-0-12-373866-0.00005-8 NADPH Betaine Homocysteine Methyltransferase, Ancient Pink DOI Oxidase can enhance Uncoupled Nitric Oxide Synthase and is inhibited by the Himalayan Sea Salt instead of Table Salt. 10.1038/sj.jhh.1002329 Xanthine Oxidase inhibitor Allopurinol. Antioxidants also assist in managing uNOS. Factor Indicative Information Wholistic Factors to Accompany Therapeutics Information Inducible Anything but Aminoguanidine, Magnesium, any of the Selective Inducible Inhibitors of Nitric Choline, Trimethylglycine, Folate/Methylfolate, Nitric Oxide Ephemeral Oxide Synthase. Inhibitors of Nitric Oxide Synthase include natural factors also, Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, Synthase. exhibition after such as Isothiocyanates, Proanthocyanidins, Terpenoids/Isoprenoids, Omega-3 Fatty Acids, Whole Food Organic Vitamins, Oncology Gestation and Carotenoids, Omega-3 Fatty acids, Polyunsaturated Fatty Acids, Circumin, and Complete Minerals, Flavonoid/Carotenoid/Phytochemical Gene after a Flavonoids. Flavonoids are diverse plant factors derived from Benzo-gamma- Supplement, Glandular Mix, KAL SOD3 or other Expression Gravitational pyrone rings that include Phenolic compounds, Pyran groups, linkages between Antioxidant Mix with Catalase and Superoxide Dismutase, challenge may be A and B rings, such that their Hydroxyl, Methoxy and Glycosidic ancillary Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, The Plasma pathogenic. structures distinguish them from one another while 3-O-Glycosides, Inhibitors of AP-1(x), including Citrus Fruit with Inducible Analytically Anthocyanins and Polymers are the most prevalently exhibited versions. Peelings/Rinds, Inhibitors of SP-1(X), Management of Nitric Oxide Significant Natural food sourced inhibitors of Inducible Nitric Oxide Synthase (iNOS) Homocysteine, Management of S-Adenosyl Homocysteine Synthase Ranges Exhibited include Cyanidin-3-rutinoside from Raspberries and cherries, Silibinin from or S-Adenosyl Homocysteine inhibitors, inhibitors of (iNOS) by Healthiest Milk thistle, Cyanidin-3-sambubioside from Peanut, Malvidin-3-arabinoside Inducible Nitric Oxide Synthase, Inhibitors of Uncouple Assay and Patients Observed from Blueberries, Malvidin-3-galactoside from Berries, Petunidin-3-arabinoside Nitric Oxide Synthase and its Reactive Molecular Species Sepsis Study in Practice. from Bilberry, Resveratrol from Grape skins, Cyanidin from Strawberries, (L-Arginine, Tetrahydrobiopterin, NADPH, Superoxide (PliNOSa® Circumin as an Delphinidin-3-arabinoside from Blueberries, Petunidin-3-glucoside from Dismutase, Catalase, Glutathione, Test) has SP1 inhibitor and Blueberries from Peonidin-3-glucoside from Black rice, Malvidin-3-glucoside Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, been utilized iNOS inhibitor from Berries, Apigenin from Celery, Carnosol from Rosemary, Delphinidin, Complete B-Vitamins with B-12 Methylcobalamin, Uridine, in studies. are therapeutic Dark berries, Proanthocyanidins from Berries, Epigallocatechin-3-gallate, Prebiotic/Probiotic to Manage Inflammation Factors for HPV, HIV Cyanidin-3-galactoside from Lingonberry, Delphinidin-3-glucoside from Produced during Ingestion of some Choline Dense Foods, and other Viral Berries, Quercetin from Broccoli, Cyanidin-3-glucoside from Black rice, Enzymes which metabolize these factors or synthesize these Pathology, Pelargonidin-3-glucoside from Strawberries, Curcumin from Curcuma, factors as well as precursors to these factors, Water, including Kaempferol from Broccoli. Peroxynitrite, iNOS and Uncoupled Nitric Oxide Phosphatidyl-Monomethylethanolamine Oncology. Synthase are known to reverse the activity Selective Serotonin Reuptake (Phosphatidylmonomethylethanolamine or PMME), Human Inhibitors, clearly presented a role for their inclusion in Obsessive, Compulsive, Rubisco, Recombinant Rubisco, Rubisco Agonists or Behavioral, and Physiological disorders, therefore also clearly presented how Rubisco Modulators, Polyacetylates, iNOS, uNOS, and Peroxynitrite produced by Communications fields, Phosphatidylethanolamine, Phosphatidylethanolamine Electromagnetic Fields and Magnetic or other fields can be modulated or with Methyltransferase, Methyltetrahydrofolate Reductase, plainly exhibited activity change or produce Human behavior. Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table salt. Factor Indicative Information Wholistic Factors to Accompany Therapeutics Information Inducible iNOS can be The referenced Article here provides precise information regarding the Choline, Trimethylglycine, Folate/Methylfolate, Nitric inhibited by preferred interactive loci between natural inhibitors of Inducible Nitric Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, Oxide shielding, coating, Oxide Synthase and Inducible Nitric Oxide Synthase Itself. Allosteric Omega-3 Fatty Acids, Whole Food Organic Vitamins, Synthase. covering, painting integration loci were found to be less prominent than substrate/inhibition Complete Minerals, Flavonoid/Carotenoid/Phytochemical Oncology with EMF Loci, such that there were diverse spatial poses exhibited by natural Supplement, Glandular Mix, KAL SOD3 or other Gene inhibiting Paint, compounds that fit into the inhibitory/substrate groove, explaining why Antioxidant Mix with Catalase and Superoxide Dismutase, Expression covering EMF many natural compounds with inhibitory effect to iNOS may inhibit Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, inhibiting cloth, inflammation widely. Fucoidan reverses iNOS reshaping of Cellular Inhibitors of AP-1(x), including Citrus Fruit with www.clinica devices, electrical structure to Amoeboid Shape. Selective inhibition of iNOS is Peelings/Rinds, Inhibitors of SP-1(X), Management of ltrials.gov/c outlets, potentiated by N - (3- (aminomethyl) benzyl)acetamidine (1400W). Homocysteine, Management of S-Adenosyl Homocysteine t2/show/NC communications Reference DOI 10.1124/jpet.106.108100 or S-Adenosyl Homocysteine inhibitors, inhibitors of T01371929 wiring and Other inhibitors of iNOS include Pimagedine, AMT, N(G)- Inducible Nitric Oxide Synthase, Inhibitors of Uncouple devices, iminoethylornithine, L-NIL, Targinine, Nitroarginine, AR-C95791, Nitric Oxide Synthase and its Reactive Molecular Species www.medip appliances, CID10398018, Etiron and numerous other CID factors. Included also (L-Arginine, Tetrahydrobiopterin, NADPH, Superoxide hos.com/m lighting, etc. EMF are Flavones Apigenin, Tangeretin, 5-Hydroxy-3,6,7,8,3,4- Dismutase, Catalase, Glutathione, ms/images/s inhibiting Hexamethoxyflavone, Flavonol Quercetin, Flavanols Epicatechin, Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, tories/medip clothing,, building Epigallocatechin-3-Gallate, Flavanone Naringenin, Isoflavone Genistein, Complete B-Vitamins with B-12 Methylcobalamin, Uridine, hosdocs/RD material, Eyewear, Terpenoids All-Trans Retinoic Acid, Methone, Omega-3 PUFAs Prebiotic/Probiotic to Manage Inflammation Factors /K1600- makeup, devices. DHA/EPA, Isothiocyanates Phenethylisothiocyanate, Sulforaphane, Produced during Ingestion of some Choline Dense Foods, PM1- Benzyl Isothiocyanate, 13 Anthocyanins of diverse nature, Enzymes which metabolize these factors or synthesize these V2.0.1-EN- iNOS exhibits Proanthocyanidin (B2), Flavonolignan Silibinin, Carotenoids Lutein, factors as well as precursors to these factors, Water, NL.pdf about %300 Lycopene, Beta-Carotene, as well as Polyphenolic Factors Curcumin, Phosphatidyl-Monomethylethanolamine percent increase in Resveratrol, Pterostilbene, [6]-Shogaol, [6]-Gingerol, and Carnosol. (Phosphatidylmonomethylethanolamine or PMME), Human potential for DOI 10.3390/molecules17078118 Aminoguanidine also scavenges Rubisco, Recombinant Rubisco, Rubisco Agonists or demise among Advanced Glycation End Products, including Alpha 2Carbonyls, Beta Rubisco Modulators, Polyacetylates, particular 2Carbonyls. DOI 10.1016/j.abb.2003.08.013 Acacia Ferruginea Phosphatidylethanolamine, Phosphatidylethanolamine conditions. ISBN inhibits iNOS and COX-2. Saponins from Platycodon Grandiflorum also Methyltransferase, Methyltetrahydrofolate Reductase, 9781603272506. inhibits iNOS. inOS may be principle cause of HPV16 high Pathogenic Betaine Homocysteine Methyltransferase, Ancient Pink Potential and Oncology Potentiation. Himalayan Sea Salt instead of Table salt. Factor Indicative Information Wholistic Factors to Accompany Therapeutics Information Symmetrical The IDEXX SDM Analytically Significant Inhibitors or Modulation of Choline, Trimethylglycine, Folate/Methylfolate, Glutathione, Dimethylarginine A Test can be used Ranges Exhibited by Symmetrical Dimethylarginine. Probiotic/Prebiotic, Complete-B Vitamins, Omega-3 Fatty for SDMA. Healthiest Patients or Homocysteine and Asymmetric Acids, Whole Food Organic Vitamins, Complete Minerals, www.idexx.com/fil Healthy Patients Dimethylarginine inhibiting factors. Flavonoid/Carotenoid/Phytochemical Supplement, es/small-animal- Observed in Practice. Omega-3. Lipoic Acid. Vitamin C. Glandular Mix, KAL SOD3 or other Antioxidant Mix with health/solutions/arti Inhibitors of PRMT5 Vitamin E. L-Carnitine. Fruits and Catalase and Superoxide Dismutase, Choline Kinase cles/intro-kidney- inhibit SDMA. The Vegetables. Protein. Alpha Lipoic Inhibitors, Tyrosine Kinase Inhibitors, Inhibitors of AP-1(x), test-sdma.pdf Hazard Ratio or 3.4 Risk Acid. Managing Homocysteine assist including Citrus Fruit with Peelings/Rinds, Inhibitors of SP- A Particular study Coefficient suggest that with SDMA levels. Inhibitors of 1(X), Management of Homocysteine, Management of S- found SDMA at its highest PRMT5 manage SMDA levels. Adenosyl Homocysteine or S-Adenosyl Homocysteine Asymmetrical levels in a study results www.epizyme.co inhibitors, inhibitors of Inducible Nitric Oxide Synthase, Dimethylarginine in a 340 percent increase m/wp-content/uploads/2014/12/ASH- Inhibitors of Uncouple Nitric Oxide Synthase and its above 1.45 in risk of Demise of all PRMT5-Presentation-Final.pdf Reactive Molecular Species (L-Arginine, Micromoles per manner of causality. Symmetrical Dimethylarginine is Tetrahydrobiopterin, NADPH, Superoxide Dismutase, Liter, Typical levels are about Known to introduce a Hazard Ratio Catalase, Glutathione, Citrulline/Arginine/Ornithine), Cardiovascular 0.5 Micromoles Per for All Cause Demise which one study NAD+, Hyaluronic Acid, Complete B-Vitamins with B-12 Risk increased. Liter. Resource, exhibits as 3.4, while some other Methylcobalamin, Uridine, Prebiotic/Probiotic to Manage DOI www.hmdb.ca/metabolit studies exhibit much more substantial Inflammation Factors Produced during Ingestion of some 10.1007/s00228- es/HMDB0003334. increases. The study presented here Choline Dense Foods, Enzymes which metabolize these 005-0014-x. uses the Risk exhibited after Ischemic factors or synthesize these factors as well as precursors to Conditions because Trimethylamine- these factors, Water, Phosphatidyl-Monomethylethanolamine N-Oxide, Asymmetrical/Symmetrical (Phosphatidylmonomethylethanolamine or PMME), Human Dimethylarginines promote Rubisco, Recombinant Rubisco, Rubisco Agonists or Vasoconstriction that may ephemeral Rubisco Modulators, Polyacetylates, occurring for substantial duration Phosphatidylethanolamine, Phosphatidylethanolamine before a health event emerges. DOI Methyltransferase, Methyltetrahydrofolate Reductase, 10.1016/j.atherosclerosis.2009.06.039 Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table salt. Factor Indicative Information Wholistic Factors to Accompany Therapeutics Information

Indoleamine 2,3- Indoleamine 2,3 – 2Oxygenase (IDO) transforms Tryptophan to Kynurenine. Choline, Trimethylglycine, Folate/Methylfolate, dioxygenase Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, GTP – Cyclohydrolase I (GTP – CH – I) produces Neopterin and enables Omega-3 Fatty Acids, Whole Food Organic Vitamins, Tetrahydrobiopterin production. Interferon – gamma activates GTP – CH – I Methanol Complete Minerals, as well as activates IDO, along with iNOS, particularly in Monocyte – extracts of Myoga Flavonoid/Carotenoid/Phytochemical Supplement, Derived Macrophages and Dendritic Cellular Entities. IDO is an Flowers and Glandular Mix, KAL SOD3 or other Antioxidant Mix immunological factor and can be the mechanism by which T Cellular Labdane with Catalase and Superoxide Dismutase, Choline Entities and Natural Demise Inducing Immune Cellular Entities activate Diterpene Kinase Inhibitors, Tyrosine Kinase Inhibitors, Inhibitors iNOS, thereby inhibiting PEMT and upregulating Choline Kinase. Pivotally, Galanol inhibit of AP-1(x), including Citrus Fruit with Peelings/Rinds, Combination therapy utilizing both Programmed Cellular Demise Protein 1, IDO while Inhibitors of SP-1(X), Management of Homocysteine, PD1, inhibitors and Inhibitors of Indoleamine 2,3-dioxygenase, IDO, are Galanol Management of S-Adenosyl Homocysteine or S-Adenosyl considered to be potent and encompassingly therapeutic enough to require Exhibited a 7.7 Homocysteine inhibitors, inhibitors of Inducible Nitric a change in practice in managing Melanoma. Such combination PD1 Micromole IC50 Oxide Synthase, Inhibitors of Uncouple Nitric Oxide inhibitor and IDO Inhibitor therapy are considered therapeutic in Cervical, while cellular Synthase and its Reactive Molecular Species (L- Bladder, Nonsmall Cellular Lung Oncology, and these analysis suggest that level IC50 was 45 Arginine, Tetrahydrobiopterin, NADPH, Superoxide these may be widely applicable to oncology which has an Immunological Nanomoles per Dismutase, Catalase, Glutathione, Inflammatory Component, those otherwise, as well as Oncology and Liter. IDO has Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, Metastatic Oncology for which no therapy has previously been available. its catalytic Complete B-Vitamins with B-12 Methylcobalamin, These include Malignant Melanoma, Renal Cellular Carcinoma, Nonsmall activity Uridine, Prebiotic/Probiotic to Manage Inflammation Cellular Lung Oncology, Hodgkin Lymphoma, Head Squamous Cellular extensively Factors Produced during Ingestion of some Choline Carcinoma, and Neck Squamous Cellular Carcinoma. IDO is prognostic for inhibited by Dense Foods, Enzymes which metabolize these factors Melanoma. 10.1016/j.ejca.2011.09.007. IDO inhibits PEMT. PD1 Quercetin, or synthesize these factors as well as precursors to conjugates inhibit AP1, resulting in enablement of PEMT although the Luteolin, these factors, Water, Phosphatidyl- downregulation of PEMT IDO and inhibition of AP1 promote SP1 Curcumin, Monomethylethanolamine availability. Sp1 availability potentiates Telomerase activity as well as Galanol, (Phosphatidylmonomethylethanolamine or PMME), potentiates iNOS or can promote other pathways to clinical prominence. Andrographolide Human Rubisco, Recombinant Rubisco, Rubisco IDO can be inhibited by preventing inflammation, preventing activation of Angelica, Agonists or Rubisco Modulators, Polyacetylates, the Adaptive Immune System, use of Hyaluronic Acid, alleviating Crysanthemums, Phosphatidylethanolamine, Phosphatidylethanolamine upregulation of CDP-Choline Pathway, alleviating upregulation of Choline Burock, Zedoary, Methyltransferase, Methyltetrahydrofolate Reductase, Kinase Pathway, as well as managing C-Reactive protein which is Andrographis. Betaine Homocysteine Methyltransferase, Ancient Pink upregulated by Complements Immune Function in response to PMCID PMC3923053. Himalayan Sea Salt instead of Table salt. overproduction of Phosphocholine. Nitrosamines/Nitrosamide/Arsenic can be managed by Kolaviron or Garcinia Kola Seed Extract. Keytruda with Yervoy and Opdivo inhibit PD1 or PD-1. Factor Indicative Information Information Wholistic Factors to Accompany Therapeutics

Trimethy γ-butyrobetaine or 4- Analytically 3,3 Dimethylbutanol (DMB) found in Choline, Trimethylglycine, Folate/Methylfolate, Glutathione, lamine- Trimethylammoniobutanoic Significant Balsamic Vinegar, Virgin Olive Oils, Probiotic/Prebiotic, Complete-B Vitamins, Omega-3 Fatty Acids, N-Oxide. acid or (3-carboxypropyl) Ranges Grapeseed Oils, Balsamic Vinegars, Whole Food Organic Vitamins, Complete Minerals, Trimethylazanium are Exhibited by Red Wines. DMB inhibits Foam Flavonoid/Carotenoid/Phytochemical Supplement, Glandular www.chl considered to be Precursors Healthiest Cellular exhibition/migration, Mix, KAL SOD3 or other Antioxidant Mix with Catalase and cme.com/ to TMAO in Microflora Patients Choline/Carnitine/Microbial TMAO, Superoxide Dismutase, Choline Kinase Inhibitors, Tyrosine wp- Metabolism. Observed in Arteriosclerosis by inhibiting Kinase Inhibitors, Inhibitors of AP-1(x), including Citrus Fruit content/u Trimethylamine is Precursor Practice. Microbial TMA Synthesis and with Peelings/Rinds, Inhibitors of SP-1(X), Management of ploads/20 in Human Metabolism. Trimethylamine promoting Decarbamoylation of Homocysteine, Management of S-Adenosyl Homocysteine or S- 16/03/T TMAO also correlates to up and its Acetylcholinesterase to exhibit Free Adenosyl Homocysteine inhibitors, inhibitors of Inducible Nitric MAO- a %297 increase in potential conversion to Amyl factors that integrate with Nitrite Oxide Synthase, Inhibitors of Uncouple Nitric Oxide Synthase Practition for demise when above 2.94 other factors is to produce Amylnitrates which are and its Reactive Molecular Species (L-Arginine, er- Micromoles per Liter utilized by potent Vasodilators. Nitrites are a Tetrahydrobiopterin, NADPH, Superoxide Dismutase, Catalase, OnePage particularly with Carotid, Marine feature of Uncoupled Nitric Oxide Glutathione, Citrulline/Arginine/Ornithine), NAD+, Hyaluronic r-CHL- Carotid Uninvolved and Organisms at Synthase. Amylnitrite is an Anti- Acid, Complete B-Vitamins with B-12 Methylcobalamin, D074.pdf lower Extremity Peripheral much depth in Angina Drug. DMB metabolized into Uridine, Prebiotic/Probiotic to Manage Inflammation Factors Artery Disease. DOI order to Carbamate can be a Convulsant. Produced during Ingestion of some Choline Dense Foods, 10.1161/JAHA.116.004237 manage Prebiotics, Antibiotics or modulators Enzymes which metabolize these factors or synthesize these pressurization of Trimethylamine-N-Oxide are factors as well as precursors to these factors, Water, Characteristics therapeutic. Avoidance of Phosphatidyl-Monomethylethanolamine of Carnitine/Phospholipid Dense Foods. (Phosphatidylmonomethylethanolamine or PMME), Human Biophysiology. Use of Liquid and easily digestible Rubisco, Recombinant Rubisco, Rubisco Agonists or Rubisco Surface Carnitine, Phospholipids and other Modulators, Polyacetylates, Phosphatidylethanolamine, organisms factors which do not accumulate Phosphatidylethanolamine Methyltransferase, utilize N,N,N progressively in Digestive pathway Methyltetrahydrofolate Reductase, Betaine Homocysteine Trimethylglyci since Meat, Chicken, Eggs and Fish, Methyltransferase, Ancient Pink Himalayan Sea Salt instead of ne. although healthy can accumulates for Table salt. months in digestive pathways. Factor Indicative Information Information Wholistic Factors to Accompany Therapeutics

Trimethy Another study shows up to Pressurization There is .0329 risk of demise with Choline, Trimethylglycine, Folate/Methylfolate, Glutathione, lamine- a 3.97 Risk Ratio or 2.97 characteristics may every micromolar increase of TMAO Probiotic/Prebiotic, Complete-B Vitamins, Omega-3 Fatty N-Oxide. increase in risk from assure vascular above the best or most optimal level. Acids, Whole Food Organic Vitamins, Complete Minerals, baseline in a range of volume, although The presumption is that Risk of Flavonoid/Carotenoid/Phytochemical Supplement, Glandular www.chl TMAO beginning with 2.9 these factors seem Adverse Behavior and Adverse Health Mix, KAL SOD3 or other Antioxidant Mix with Catalase and cme.com at baseline and concluding to have a priority Events are higher. Much higher. Superoxide Dismutase, Choline Kinase Inhibitors, Tyrosine /wp- at 21.9 at the highest level. function in assuring NAD+ and Water are required to Kinase Inhibitors, Inhibitors of AP-1(x), including Citrus content/u This suggests that for each the shape, twist and transform y-Butyrobetaine into its Fruit with Peelings/Rinds, Inhibitors of SP-1(X), ploads/20 integer micromolar writhe of molecules Acid in Digestive Pathway Management of Homocysteine, Management of S-Adenosyl 16/03/T increment in TMAO there as they incur Microflora. DMB is suggested as an Homocysteine or S-Adenosyl Homocysteine inhibitors, MAO- is an increase of 0.16 in risk changes in inhibitor of Clostridales and inhibitors of Inducible Nitric Oxide Synthase, Inhibitors of Practitio of Demise. The risk, based metabolism Firmicutes Microflora. . Importantly, Uncouple Nitric Oxide Synthase and its Reactive Molecular ner- upon quartile information (Plasticity). A Trimethylamine can be reduced to Species (L-Arginine, Tetrahydrobiopterin, NADPH, OnePage seems to begin no higher monthly Laxative at Trimethylamine-N-Oxide not only by Superoxide Dismutase, Catalase, Glutathione, r-CHL- than 3.3 Micromoles Per a minimum assists Flavin Monooxygenase, but also by Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, D074.pdf liter and is probably lower. in removing Peroxynitrite, Superoxide, Hydrogen Complete B-Vitamins with B-12 Methylcobalamin, Uridine, DOI accumulation of Peroxide and Hypochlorite. Prebiotic/Probiotic to Manage Inflammation Factors 10.1161/JAHA.116.004237 Carnitine, Peroxynitrite, Superoxide, H202, and Produced during Ingestion of some Choline Dense Foods, Phospholipids, or Hypochlorite are known to be able to Enzymes which metabolize these factors or synthesize these other factors in reduce TMA to TMAO, as does FMO, factors as well as precursors to these factors, Water, digestive pathways, TMA Lyase from Microbes and Phosphatidyl-Monomethylethanolamine resetting the cycle Processing of Butyryl Betaine, all of (Phosphatidylmonomethylethanolamine or PMME), Human of cumulative which can be prevented by optimal Rubisco, Recombinant Rubisco, Rubisco Agonists or Rubisco remnants of foods Choline Metabolites, Antibiotics, Modulators, Polyacetylates, Phosphatidylethanolamine, which supply less Probiotics, Glutathione, Catalase, Phosphatidylethanolamine Methyltransferase, than optimal Glutathione Peroxidase, Catalase, Methyltetrahydrofolate Reductase, Betaine Homocysteine bacteria with Vitamin C, N – Acetyl Cysteine, or Methyltransferase, Ancient Pink Himalayan Sea Salt instead sustaining material. Other Antioxidants as well as of Table salt. assurance of Coupling of Nitric Oxide Synthase activity. Factor Indicative Information Wholistic Factors to Accompany Therapeutics Information Monocyte Biomarker Analytically Significant www.google.com Choline, Trimethylglycine, Folate/Methylfolate, Chemoattrac Testing for Ranges Exhibited by /patents/US69 Glutathione, Probiotic/Prebiotic, Complete-B tant Protein MCP-1. Healthiest Patients Observed 53809 exhibits Vitamins, Omega-3 Fatty Acids, Whole Food Organic 1. Oncology www.crlcorp.co in Practice. Phyllostachys Inhibitors of Vitamins, Complete Minerals, Gene m/product/mo edulis or Tortoise Shell MCP-1. DHA Flavonoid/Carotenoid/Phytochemical Supplement, Expression. nocyte- Bamboo inhibits MCP-1. and Omega-3 Glandular Mix, KAL SOD3 or other Antioxidant Mix chemotactic- Inhibiting Oxidized Low inhibit MCP-1. with Catalase and Superoxide Dismutase, Choline protein-1/ Density Lipoprotein inhibits digital object Kinase Inhibitors, Tyrosine Kinase Inhibitors, MCP-1. Parthenolide and identifier Inhibitors of AP-1(x), including Citrus Fruit with Bindarit and Arglabin from Feverfew, 10.1002/mnfr.2 Peelings/Rinds, Inhibitors of SP-1(X), Management of Cilostozal Tenacetum Parthenium as 01400196. A Homocysteine, Management of S-Adenosyl inhibit MCP1, well as from Artemisia Murine Inhibitor Homocysteine or S-Adenosyl Homocysteine inhibitors, MCP-1. Glabella, Smooth Wormwood, of MCP-1 is inhibitors of Inducible Nitric Oxide Synthase, inhibits MCP1, is Oncology mNOX-E36. Inhibitors of Uncouple Nitric Oxide Synthase and its Therapeutic, inhibits Reactive Molecular Species (L-Arginine, Interleukin mediated Islet Tetrahydrobiopterin, NADPH, Superoxide Dismutase, Beta Cellular Apoptosis from Catalase, Glutathione, Citrulline/Arginine/Ornithine), Caspase-1 and causes NAD+, Hyaluronic Acid, Complete B-Vitamins with B- Apoptosis in Acute Chronic 12 Methylcobalamin, Uridine, Prebiotic/Probiotic to Myelogenous Leukemia Manage Inflammation Factors Produced during Stem/Progenitor Cellular Ingestion of some Choline Dense Foods, Enzymes entities. which metabolize these factors or synthesize these factors as well as precursors to these factors, Water, Phosphatidyl-Monomethylethanolamine (Phosphatidylmonomethylethanolamine or PMME), Human Rubisco, Recombinant Rubisco, Rubisco Agonists or Rubisco Modulators, Polyacetylates, Phosphatidylethanolamine, Phosphatidylethanolamine Methyltransferase, Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table salt. Factor Indicative Information Information Wholistic Factors to Accompany Therapeutics

Monocyte Micheliolide (MCL) Blood, Volume 105, N,N,N′,N′- Choline, Trimethylglycine, Folate/Methylfolate, Chemoattra and Isoalantolactone Issue 11, Page 4163. Tetrakis(2- Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, ctant also inhibit MCP-1, www.wur.nl/en/articl pyridylmethyl)eth Omega-3 Fatty Acids, Whole Food Organic Vitamins, Protein 1. NF kB, IkBalpha, e/New-method-for- ylenediamine Complete Minerals, Oncology TGF-beta1, and FN. the-production-of-the- (TPEN) and the Flavonoid/Carotenoid/Phytochemical Supplement, Gene digital object identifier compounds-with- heavy metal Glandular Mix, KAL SOD3 or other Antioxidant Mix with Expression. 10.3390/molecules18 anticancer-activity- chelator 2,3- Catalase and Superoxide Dismutase, Choline Kinase 1013061 Arglabin-and- dimercapto-1- Inhibitors, Tyrosine Kinase Inhibitors, Inhibitors of AP- Ciclesonide inhibits Parthenolide-1.htm propanesulfonic 1(x), including Citrus Fruit with Peelings/Rinds, MCP-1, TNF-alpha digital object acid (DMPS) Inhibitors of SP-1(X), Management of Homocysteine, and Interluekin-1b. identifier inhibit MCP-1. Management of S-Adenosyl Homocysteine or S-Adenosyl Phyllostachys edulis /10.1124/jpet.116.23 digital object Homocysteine inhibitors, inhibitors of Inducible Nitric or Tortoise Shell 2934 identifier Oxide Synthase, Inhibitors of Uncouple Nitric Oxide Bamboo inhibits MCP- 10.1152/ajplung. Synthase and its Reactive Molecular Species (L-Arginine, 1. Inhibiting Oxidized 00406.2002 Tetrahydrobiopterin, NADPH, Superoxide Dismutase, Low Density Catalase, Glutathione, Citrulline/Arginine/Ornithine), Lipoprotein inhibits NAD+, Hyaluronic Acid, Complete B-Vitamins with B-12 MCP-1 Methylcobalamin, Uridine, Prebiotic/Probiotic to Manage Inflammation Factors Produced during Ingestion of some Choline Dense Foods, Enzymes which metabolize these factors or synthesize these factors as well as precursors to these factors, Water, Phosphatidyl- Monomethylethanolamine (Phosphatidylmonomethylethanolamine or PMME), Human Rubisco, Recombinant Rubisco, Rubisco Agonists or Rubisco Modulators, Polyacetylates, Phosphatidylethanolamine, Phosphatidylethanolamine Methyltransferase, Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table salt. Factor Indicative Information Wholistic Factors to Accompany Therapeutics Information Testosterone Free Females exhibit Analytically Significant Ranges Phospholipids, Choline, Trimethylglycine, Folate/Methylfolate, Glutathione, Testosterone CPT 1, 9, 14, 19, and Exhibited by Healthiest Patients START Proteins, Probiotic/Prebiotic, Complete-B Vitamins, Omega-3 Fatty Acids, Whole Code 84402 and Adult Observed in Practice Males Cholesterol and Food Organic Vitamins, Complete Minerals, Aggregate Testosterone at typically exhibit 1, 9, 14, 18 and Wholistic Factors, Flavonoid/Carotenoid/Phytochemical Supplement, Glandular Mix, KAL Testosterone CPT 0.00001, adult Testosterone at 0.000198, Pregnenolone, SOD3 or other Antioxidant Mix with Catalase and Superoxide Dismutase, Code 84403 0.00001, 0.0000035, 0.0025, Testosterone, Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, Inhibitors of AP-1(x), www.blog.superco 0.0000173, 0.000017/0.00049, 0.013 NADPH, Choline, including Citrus Fruit with Peelings/Rinds, Inhibitors of SP-1(X), der.com/cpt-codes- 0.00125 Micromoles per liter. 17Beta-Estradiol. Management of Homocysteine, Management of S-Adenosyl Homocysteine 2/what- Micromoles per Androgens include or S-Adenosyl Homocysteine inhibitors, inhibitors of Inducible Nitric Oxide documentation-is- Liter. Testosterones and Estrogens. Synthase, Inhibitors of Uncouple Nitric Oxide Synthase and its Reactive needed-for- Pregnenolone is known to be an Molecular Species (L-Arginine, Tetrahydrobiopterin, NADPH, Superoxide coding-a- intermediary in production of Dismutase, Catalase, Glutathione, Citrulline/Arginine/Ornithine), NAD+, testosterone-shot/ Estrogens and Testosterone. Hyaluronic Acid, Complete B-Vitamins with B-12 Methylcobalamin, Human Metabolome Database Uridine, Prebiotic/Probiotic to Manage Inflammation Factors Produced Information. during Ingestion of some Choline Dense Foods, Enzymes which metabolize these factors or synthesize these factors as well as precursors to these factors, Water, Phosphatidyl-Monomethylethanolamine (Phosphatidylmonomethylethanolamine or PMME), Human Rubisco, Recombinant Rubisco, Rubisco Agonists or Rubisco Modulators, Polyacetylates, Phosphatidylethanolamine, Phosphatidylethanolamine Methyltransferase, Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table salt. Factor Indicative Information Information Wholistic Factors to Accompany Therapeutics

17Beta-estradiol Lowered levels of Analytically Significant Phospholipids, Choline, Trimethylglycine, Folate/Methylfolate, Glutathione, Levels Estrogen, Estradiol, Ranges Exhibited by START Proteins, Probiotic/Prebiotic, Complete-B Vitamins, Omega-3 Fatty Acids, Whole Ultrasenstitive 17Beta-Estradiol, Healthiest Patients Observed Cholesterol and Food Organic Vitamins, Complete Minerals, 17beta-Estradiol. Estrone or Estriol. in Practice. Androgens Wholistic Factors, Flavonoid/Carotenoid/Phytochemical Supplement, Glandular Mix, KAL www.rmlonline.c 17Beta Estradiol is include Estrogens and Pregnenolone, SOD3 or other Antioxidant Mix with Catalase and Superoxide Dismutase, om/site/labtests/3 transformed into Testosterones. Pregnenolone Testosterone, Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, Inhibitors of AP- 600375 Testosterone. Female 9, is known to be an NADPH, Choline, 1(x), including Citrus Fruit with Peelings/Rinds, Inhibitors of SP-1(X), 11, 12, 14, 19 and adult intermediary in production of 17Beta-Estradiol Management of Homocysteine, Management of S-Adenosyl levels levels of Estrogens and Testosterone. each enhance Homocysteine or S-Adenosyl Homocysteine inhibitors, inhibitors of Estradiol are typically Male 11, 13, 15, 19 and Steroidogenesis. Inducible Nitric Oxide Synthase, Inhibitors of Uncouple Nitric Oxide 0.00037, 0.000176, Adult levels of Estradiol are Inhibiting AP-1 Synthase and its Reactive Molecular Species (L-Arginine, 0.000345, typically 0.000048, and Choline Tetrahydrobiopterin, NADPH, Superoxide Dismutase, Catalase, 0.0000f4/0.000631, 0.000095, 0.000103, 0.00014 Kinase, as well as Glutathione, Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, 0.000936, and 0.00015 and 0.000220 Micromoles SP-1.START Complete B-Vitamins with B-12 Methylcobalamin, Uridine, Micromoles per Liter.. Per Liter. Human Protein D2. Prebiotic/Probiotic to Manage Inflammation Factors Produced during Metabolome Database Ingestion of some Choline Dense Foods, Enzymes which metabolize Information. these factors or synthesize these factors as well as precursors to these factors, Water, Phosphatidyl-Monomethylethanolamine (Phosphatidylmonomethylethanolamine or PMME), Human Rubisco, Recombinant Rubisco, Rubisco Agonists or Rubisco Modulators, Polyacetylates, Phosphatidylethanolamine, Phosphatidylethanolamine Methyltransferase, Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table salt. Factor Indicative Information Information Wholistic Factors to Accompany Therapeutics Thrombin. There are potent direct Thrombin inhibitors Choline, Trimethylglycine, Folate/Methylfolate, www.nejm.org/doi/full/10.1056/NEJMra044440 Tissue Factor is expressed and requires Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, A summarization of the Phospholipids to participate in Coagulation, requires any phospholipid other Omega-3 Fatty Acids, Whole Food Organic Vitamins, Coagulation Cascade Phosphatidylcholine to become active when low levels of Phosphatidylserine are available, Complete Minerals, Flavonoid/Carotenoid/Phytochemical seems to present a more as well as can be optimal when Phosphatidylserine is adequately available. Supplement, Glandular Mix, KAL SOD3 or other complete understanding of Phosphatidylserine may enhance Coagulation in an emergency condition or circumstance Antioxidant Mix with Catalase and Superoxide why Thrombin inhibits otherwise. Inhibiting the availability of Phosphatidylserine, then, can inhibit coagulation Dismutase, Choline Kinase Inhibitors, Tyrosine Kinase PEMT. These pathways when it is not considered to be required or optimal. Phosphatidylcholine, then, also inhibits Inhibitors, Inhibitors of AP-1(x), including Citrus Fruit seem to compete for Coagulation as may Choline constitutively, although Choline can enhance genetic with Peelings/Rinds, Inhibitors of SP-1(X), Management control of Serine Proteases transcription of many factors. A summarization of the Coagulation Cascade, thus, seems to of Homocysteine, Management of S-Adenosyl within Biophysiology, present a more complete understanding of why Thrombin inhibits PEMT. These pathways Homocysteine or S-Adenosyl Homocysteine inhibitors, while PEMT promotes seem to compete for control of Serine Proteases within Biophysiology, while PEMT inhibitors of Inducible Nitric Oxide Synthase, Inhibitors both inhibition of Scaring promotes both the inhibition of Scaring and enables regenerative Blastema exhibition, of Uncouple Nitric Oxide Synthase and its Reactive and enables regenerative along with preventing of Apoptosis and Necrosis along enhancement of biosynthesis and Molecular Species (L-Arginine, Tetrahydrobiopterin, Blastema exhibition, along noninflammatory apoptosis as a mechanisms of beneficial regenerative flux. Thrombin NADPH, Superoxide Dismutase, Catalase, Glutathione, with preventing of seems to be invoked or promoted to clinical prominence because of physiological sensing Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, Apoptosis and Necrosis. of an essential time component to impaired physiology in which maintaining structure Complete B-Vitamins with B-12 Methylcobalamin, The activity of PEMT is becomes more important than persisting regenerative flux. Coagulation or Thrombin time Uridine, Prebiotic/Probiotic to Manage Inflammation compared with the is diagnostic analysis of how long a particular biological fluid context requires to exhibit Factors Produced during Ingestion of some Choline Dense promoting of coagulation, while Thrombin produced from Prothrombin is not directly potentiated from Foods, Enzymes which metabolize these factors or Inflammation Pathways by Arachidonic Acid, but requires an additional phases of catalytic activity to become synthesize these factors as well as precursors to these the Coagulation Cascade Thrombin, plainly exhibiting correlation in this regard. The activity of PEMT is compared factors, Water, PhosphatidylMonomethylethanolamine Pathways with the promoting of Inflammation Pathways by the Coagulation Cascade Pathways. (Phosphatidylmonomethylethanolamine or PMME), Thus, it may be prudent to determine a condition which requires Inflammation pathways Human Rubisco, Recombinant Rubisco, Rubisco Agonists and the detriment to biophysiology which is potentiated by such pathways comparatively to or Rubisco Modulators, Polyacetylates, a condition in which structural aspects of biophysiology are assured such that regenerative Phosphatidylethanolamine, Phosphatidylethanolamine pathways should be promoted over Coagulation/Inflammation Pathways. Intracellular Methyltransferase, Methyltetrahydrofolate Reductase, influx of Ca2+ promotes Coagulation, thus iNOS may be a coagulation stimulator. Betaine Homocysteine Methyltransferase, Ancient Pink Molecules with the amino acid sequence Glycine, Proline, Arginine, and Proline Sequence Himalayan Sea Salt instead of Table salt. are suggested to be potent inhibitors of Fibrin associated Coagulation and are considered to be potent inhibitors of Coagulation by Fibrinogen. PMID 8428923. Homocysteine Occupies Fibronectin and increases Free Fibrin which can promote Coagulation or Fibrin Polymerization. DOI 10.1002/dvdy.10303 DOI 10.1161/01.ATV. Factor Indicative Information Information Wholistic Factors to Accompany Therapeutics Thrombin. Super Thrombolytics or Clot Busters, Heparin and other factor can inhibit, prevent or Choline, Trimethylglycine, Folate/Methylfolate, Coagulation duration reverse Thrombosis or Coagulation otherwise. www.webmd.com/heart- Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, test Thus, it may be disease/guide/medicine-clot-busters. Short duration inhibition of Vitamin K with Omega-3 Fatty Acids, Whole Food Organic Vitamins, prudent to determine a longer duration management of causes of inflammation and Coagulation cascade may be Complete Minerals, Flavonoid/Carotenoid/Phytochemical condition which optimal. 3 Pharmacological capabilities of inhibiting Thrombin, Ximelagatran, Supplement, Glandular Mix, KAL SOD3 or other requires Inflammation Dabigatran Etexilate, and Argatroban, each seem to share an Aryl Hydrocarbon that Antioxidant Mix with Catalase and Superoxide Dismutase, pathways and the exhibits either a connected Sulfur or Carbon, which then exhibits angle branched Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, detriment to Nitrogen. www.labtestsonline.org/understanding/analytes/thrombin-time/tab/test. Inhibitors of AP-1(x), including Citrus Fruit with biophysiology which is Vasoconstriction from Trimethylamine-N-Oxide can modulate the Thrombin associated Peelings/Rinds, Inhibitors of SP-1(X), Management of potentiated by such Serine Protease Cascade that include Kinin, Kallikrein, Bradykinin, Vasomodulation, Homocysteine, Management of S-Adenosyl Homocysteine pathways Cardiac Pace, Pressurization, Coagulation, Inflammation, Discomfort and other or S-Adenosyl Homocysteine inhibitors, inhibitors of comparatively to a Characteristic. PEMT Enzyme function typically downregulates these except for Serine Inducible Nitric Oxide Synthase, Inhibitors of Uncouple condition in which Protease activity which PEMT enables, suggesting why Thrombin inhibits PEMT. Nitric Oxide Synthase and its Reactive Molecular Species structural aspects of exhibition. Managing Reactive Oxygen Species, Uncoupled Nitric Oxide Synthase and (L-Arginine, Tetrahydrobiopterin, NADPH, Superoxide biophysiology are Inducible Nitric Oxide Synthase can reduce the Negatively Polarized Reactive Dismutase, Catalase, Glutathione, assured such that Molecular Species which induce Coagulation. Thrombin is inversely correlated with Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, regenerative pathways Stroke, presumably because TMAO is correlated with Stroke while TMAO is Complete B-Vitamins with B-12 Methylcobalamin, should be promoted upregulated when factors exhibiting Choline and Carnitine are increased in level of Uridine, Prebiotic/Probiotic to Manage Inflammation over obtainment. Because of less than optimal digestive pathway Microflora, TMAO can Factors Produced during Ingestion of some Choline Dense Coagulation/Inflammat replace Homocysteine as a principle Risk Factor. A research article, although Foods, Enzymes which metabolize these factors or ion Pathways. suggesting the Thrombolytics and ‘Clot Busters’, as well as Mechanical Procedures are synthesize these factors as well as precursors to these Detailed information among highest performing potential candidates for therapeutic Validation by Clinical factors, Water, Phosphatidyl-Monomethylethanolamine on Coagulation Studies, observes that the clinical literature pervasively presents the use Recombinant (Phosphatidylmonomethylethanolamine or PMME), influencing Tissue Plasminogen Factor Activation as a preferred method of Stroke Intervention. Human Rubisco, Recombinant Rubisco, Rubisco Agonists therapeutics and foods. These analyses suggest that management of TMAO, Gamma Butyryl Betaine, TMA or Rubisco Modulators, Polyacetylates, Digital Object Lyase, Digestive Pathway Bacteria, Uncoupled NOS. iNOS, Homocysteine, Phosphatidylethanolamine, Phosphatidylethanolamine Identifier. Peroxynitrite, Superoxide, H2O2 and Hypochlorite may be the best primary intervention Methyltransferase, Methyltetrahydrofolate Reductase, 10.1016/j.blre.2017.02. capability which can begin before being accepted into the Emergency Department. DOI Betaine Homocysteine Methyltransferase, Ancient Pink 001 10.1161/STROKEAHA.107.181486 Metalloproteinases may also require management Himalayan Sea Salt instead of Table salt. as these may cause Vascular Plaque Rupture. Aminocaproic Acid inhibits Plasmin, which deteriorates Plaque and clots. Factor Indicative Information Wholistic Factors to Accompany Therapeutics Information

Asymmetrical Uncoupled Nitric Analytically Inhibitors or modulation of Choline, Trimethylglycine, Folate/Methylfolate, Dimethyl Oxide Synthase, Significant Ranges Asymmetrical Dimethyl Arginine, Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, Arginine. Nitrites or Specific Exhibited by Including L – Arginine, Omega-3 Fatty Acids, Whole Food Organic Vitamins, Diagnostic Assay Gravity Test for Healthiest Patients Dimethylarginine Complete Minerals, Flavonoid/Carotenoid/Phytochemical for Asymmetrical Uretic Output. Observed in Practice. Dimethylaminohydrolase 1 (DADH1), Supplement, Glandular Mix, KAL SOD3 or other Dimethylarginine 0.30 Micromoles Dimethylarginine Antioxidant Mix with Catalase and Superoxide Dismutase, CPT code 82542. per Liter or less is Asymmetrical Dimethylaminohydrolase 2 (DADH2), Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, www.pdl.testcatal considered typical Dimethylarginine is Nitric Oxide Synthase, Estrogen Inhibitors of AP-1(x), including Citrus Fruit with og.org/show/AD for Asymmetrical Known to introduce Factors, Oestradiol, Retinoic Acid, Peelings/Rinds, Inhibitors of SP-1(X), Management of MA Dimethylarginine a Hazard Ratio for Rosglitiazone, Choline, Betaine, Homocysteine, Management of S-Adenosyl Homocysteine although there was a All Cause Demise Phosphatidylcholine, Complete B or S-Adenosyl Homocysteine inhibitors, inhibitors of range that could be which one study Vitamins, Citrulline, Ornithone, Nitric Inducible Nitric Oxide Synthase, Inhibitors of Uncouple estimated to be as exhibits as 2.07, Oxide Synthase, Vitamin E, Probucol, Nitric Oxide Synthase and its Reactive Molecular Species high as 0.40 while some other Xanthones, Calcitonin Gene (L-Arginine, Tetrahydrobiopterin, NADPH, Superoxide Micromoles per studies exhibit much Associated Peptide (CGRP), Low Dismutase, Catalase, Glutathione, Liter, particularly more substantial levels of Capsaicin, Farnesoid X Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, because Health increases. Receptor Agonist GW4064, Other Complete B-Vitamins with B-12 Methylcobalamin, Conditions exhibit supplements, Other pharmacological Uridine, Prebiotic/Probiotic to Manage Inflammation levels as low as 0.66 capabilities, Co-Factors to Nitric Factors Produced during Ingestion of some Choline Dense Micromoles per Oxide Synthase (Tetrahydrobiopterin Foods, Enzymes which metabolize these factors or Liter. or BH4, Calmodulin CaM, NADPH, synthesize these factors as well as precursors to these FMN, and FAD), Nitrate, Glycine factors, Water, Phosphatidyl-Monomethylethanolamine Propionyl-L-Carnitine, Vitamin E, (Phosphatidylmonomethylethanolamine or PMME), Probucol, Xanthones, Human Rubisco, Recombinant Rubisco, Rubisco Agonists Diphenyliodonium, Symmetric or Rubisco Modulators, Polyacetylates, Dimethylalamine, Betaine may inhibit Phosphatidylethanolamine, Phosphatidylethanolamine changes to Quaternary structure which Methyltransferase, Methyltetrahydrofolate Reductase, might potentiate Asymmetric Betaine Homocysteine Methyltransferase, Ancient Pink Methylation, particularly of ADMA. Himalayan Sea Salt instead of Table salt. Factor Indicative Information Information Wholistic Factors to Accompany Therapeutics

Asymmetrical Uncoupled Nitric Oxide The study presented here Choline may contribute Methyl resources Choline, Trimethylglycine, Folate/Methylfolate, Dimethyl Synthase, Nitrites or uses the Risk exhibited which may enable Methyltransferases to also Glutathione, Probiotic/Prebiotic, Complete-B Arginine. Specific Gravity Test after Ischemic Conditions Methylate the Cys His Glu domain, Vitamins, Omega-3 Fatty Acids, Whole Food Organic Diagnostic for Uretic Output. because Trimethylamine- Pioglitazone, Ornithine, Trascarbamylase, Vitamins, Complete Minerals, Assay for 0.30 Micromoles per N-Oxide, Leeks, Aliskiren, Vitamin A, Beta Carotene, Flavonoid/Carotenoid/Phytochemical Supplement, Asymmetrical Liter or less is Asymmetrical/Symmetric Soy, Sesame Seeds, Aspirin and Aspiring Glandular Mix, KAL SOD3 or other Antioxidant Mix Dimethylargini considered typical for al Dimethylarginines exhibiting Nutritional factors, Simvastatin, with Catalase and Superoxide Dismutase, Choline ne CPT code Asymmetrical promote Vasoconstriction Other Statins, Angiotensin Converting Kinase Inhibitors, Tyrosine Kinase Inhibitors, 82542. Dimethylarginine that may ephemeral Enzyme Inhibitors (ACEs) or Factors Inhibitors of AP-1(x), including Citrus Fruit with www.pdl.testcat although there was a occurring for substantial Exhibiting ACEs, Angiotensin 2 Receptor Peelings/Rinds, Inhibitors of SP-1(X), Management of alog.org/show/ range that could be duration before a health Blockers (ARBs) or Factors Exhibiting Homocysteine, Management of S-Adenosyl ADMA estimated to be as high event emerges. DOI ARBs, Metformin or Metformin exhibiting Homocysteine or S-Adenosyl Homocysteine inhibitors, as 0.40 Micromoles per 10.1016/j.atherosclerosis. factors, Water. Alpha Lipoic Acid. Phenols inhibitors of Inducible Nitric Oxide Synthase, Liter, particularly 2009.06.039 and Polyphenols such as in honey, legumes, Inhibitors of Uncouple Nitric Oxide Synthase and its because Health apples, blackberries, blueberries, cantaloupe, Reactive Molecular Species (L-Arginine, Conditions exhibit pomegranate, cherries, cranberries, grapes, Tetrahydrobiopterin, NADPH, Superoxide Dismutase, levels as low as 0.66 pears, plums, raspberries, Aronia berries, Catalase, Glutathione, Citrulline/Arginine/Ornithine), Micromoles per Liter. stra2berries, broccoli, artichoke, cabbage, NAD+, Hyaluronic Acid, Complete B-Vitamins with celery, onion, parsley, red wine, chocolate, B-12 Methylcobalamin, Uridine, Prebiotic/Probiotic to black tea, white tea, green tea, olive oil, Manage Inflammation Factors Produced during grains Ingestion of some Choline Dense Foods, Enzymes which metabolize these factors or synthesize these factors as well as precursors to these factors, Water, Phosphatidyl-Monomethylethanolamine (Phosphatidylmonomethylethanolamine or PMME), Human Rubisco, Recombinant Rubisco, Rubisco Agonists or Rubisco Modulators, Polyacetylates, Phosphatidylethanolamine, Phosphatidylethanolamine Methyltransferase, Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table salt. Factor Indications Information Wholistic Factors to Accompany Therapeutics Choline Kinase Inhibitors of www.pubs.acs.org/doi/abs/10.1021/acs.jmedchem.5b01552?journalCode=jmcmar, Choline, Trimethylglycine, Folate/Methylfolate, Inhibitors choline carbocyanine dye, JAS239. Hemicholinium-3. 2-dimethylaminoethanol Glutathione, Probiotic/Prebiotic, Complete-B Choline Kinase A Kinase can DMAE(also inhibits Choline Endocytosis). ASAH1 Acid Ceramidase Inhibitors to Vitamins, Omega-3 Fatty Acids, Whole Food Organic and B often exhibit help with resistance. Betaine inhibits both Choline Kinase and Ethanolamine Vitamins, Complete Minerals, Elisa Test, Hexameter Kinase. Purinyl-6-Histamine specifically inhibits Choline Kinase and induces Flavonoid/Carotenoid/Phytochemical Supplement, Oncology Gene structure Cytotoxicity only in Oncology Exhibiting Cellular Entities. These clearly suggest Glandular Mix, KAL SOD3 or other Antioxidant Mix Expression. while also that Choline Kinase, which is upregulated by the Xenobiotic Response System, is a with Catalase and Superoxide Dismutase, Choline being linked member of the Xenobiotic, Allergy, Pruritus, and Immunologic Response Systems. Kinase Inhibitors, Tyrosine Kinase Inhibitors, www.mybiosourc through Inhibition of Protein Kinase A inhibits choline Kinase Beta. Managing iNOS, Inhibitors of AP-1(x), including Citrus Fruit with e.com/prods/ELI linkages to Thrombin, AP-1 and SP-1 can downregulate Choline Kinase Alpha. Peelings/Rinds, Inhibitors of SP-1(X), Management of SA- other ringed Hexadecyltrimethylammonium Bromide inhibits Choline Kinase Alpha in Homocysteine, Management of S-Adenosyl Kit/Human/choli moieties that Plasmodium Falciparum. The erectile dysfunction therapies Sildenafil, Tadalafil Homocysteine or S-Adenosyl Homocysteine ne-kinase- are Aryl and Vardenafil are carbocyanines and exhibit required Dual Ringed inhibitors, inhibitors of Inducible Nitric Oxide beta/CHKB/datas Hydrocarbons Pentameter/Hexameter Pyrimidine/Imidazole Ring. DMAE and Betaine as N,N,N, Synthase, Inhibitors of Uncouple Nitric Oxide heet.php?product or themselves Trimethylglycine or N,N,N,Glycine Betaine, each inhibit Choline Kinase although Synthase and its Reactive Molecular Species (L- s_id=920777 being Aryl these have been shown to also downregulate PEMT. Other inhibitors of Choline Arginine, Tetrahydrobiopterin, NADPH, Superoxide Carbon Kinase include Hemicholinium-3, Bis-quinolinium factors, Acyclic Biscationic Dismutase, Catalase, Glutathione, www.mybiosourc Hexameters. Pyridophane factors, Acyclic Biscationic Quinolinephane Factors, Bispyridinium Citrulline/Arginine/Ornithine), NAD+, Hyaluronic e.com/prods/ELI Morpholine Cyclophanes, as well as 5,5’ Dithiobis (2 - Nitrobenzoic Acid), as well as 4’ – Acid, Complete B-Vitamins with B-12 SA- inhibits Bispyridyl – 5,5’ Perfluoroalkyl – 2,2’ – Bisoxazol, also 4 – Chloro – N Methylcobalamin, Uridine, Prebiotic/Probiotic to Kit/Human/choli Choline Methylanilino, also 5 – Fluorouracil, Adenosine, Choline Analogues, MN58b, Manage Inflammation Factors Produced during ne-kinase- Kinase and is TCD828, TCD – 717, Piperazine, CK37, P1-103, Cyclophane, N – Ingestion of some Choline Dense Foods, Enzymes alpha/CHKA/dat structural Methylmaleimide, Quinacrine, and Stearoyl-CoA. Symmetrical Bisquinolinium which metabolize these factors or synthesize these asheet.php?produ aspects of US20150338425 A1, United States Patent and Trademark Office Publication factors as well as precursors to these factors, Water, cts_id=909230. Tannins and Number. ICL-CCIC-0019 inhibits choline Kinase. DOI 10.18632/oncotarget.9466 Phosphatidyl-Monomethylethanolamine Polyphenols TCD-717 inhibits Choline Kinase Alpha. (Phosphatidylmonomethylethanolamine or PMME), from Teas, www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=687183 Human Rubisco, Recombinant Rubisco, Rubisco Fruits, Hemoicholinium-3 inhibits Choline Kinase. RSM-932A inhibits Choline Kinase Agonists or Rubisco Modulators, Polyacetylates, Vegetables, Alpha. Near-Infrared Fluorescent Carbocyanine inhibits Choline Kinase PMCID Phosphatidylethanolamine, Phosphatidylethanolamine and Red PMC4209917. The Viral DNA Polymerase Inhibitor CidifoVIr CDV or HPMPC Methyltransferase, Methyltetrahydrofolate Reductase, Wines. may be therapeutic in pervasive viral oncology, because it also performs as a Betaine Homocysteine Methyltransferase, Ancient Choline Kinase Inhibitor by storing of Choline as CDVp Choline. Pink Himalayan Sea Salt instead of Table salt. Factor Indicative Information Wholistic Factors to Accompany Therapeutics Information NF kB. NF kB DHA and Omega-3. Lutein from Citrus Inflammation indicators are Choline, Trimethylglycine, Folate/Methylfolate, Oncology Gene Diagnostic Bioflavonoids, Basil, Artichoke, Celery, generally associated with a Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, Expression. Assay. Thyme, Peppermint, Parsley, Green Pepper. 50% increase risk of Demise. Omega-3 Fatty Acids, Whole Food Organic Vitamins, www.fiveph www.raysahelian.com/luteolin.html. Aucubin www.joshmitteldorf.scienceb Complete Minerals, Flavonoid/Carotenoid/Phytochemical oton.com/in from Plantain. Oestrogen. Carahealth.com log.com/2017/03/08/nf-kb- Supplement, Glandular Mix, KAL SOD3 or other dex.php?rou Website. emetine, fluorosalan, sunitinib beyond-inflammation/ Antioxidant Mix with Catalase and Superoxide te=product/p malate, bithionol, narasin, tribromsalan, and Flavone, Isorhamnetin, Dismutase, Choline Kinase Inhibitors, Tyrosine Kinase roduct&prod lestaurtinib. ectinascidin 743, chromomycin Pelargonidin and Naringenin Inhibitors, Inhibitors of AP-1(x), including Citrus Fruit uct_id=83 A3 and bortezomib. Numerous others. inhibit NF –KappaB while with Peelings/Rinds, Inhibitors of SP-1(X), Management PMCID PMC2834878. Supplementing with Genistein, Daidzein, of Homocysteine, Management of S-Adenosyl Omega – 3 Fatty acids enables up to a 25 Kaempferol and Quercetin Homocysteine or S-Adenosyl Homocysteine inhibitors, percent decrease in potential for demaise. DOI inhibit STAT - 1 and NF - kB. inhibitors of Inducible Nitric Oxide Synthase, Inhibitors 10.3390/nu9040363 DOI 10.1155/2007/45673 of Uncouple Nitric Oxide Synthase and its Reactive Molecular Species (L-Arginine, Tetrahydrobiopterin, TNF-Alpha www.questdi Naltrexone. Xanthohumol from Hops. Inflammation indicators are NADPH, Superoxide Dismutase, Catalase, Glutathione, agnostics.co Glycine. Omega-3 and Phospholipids as in generally associated with a Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, m/testcenter/ Fish Oil. Quercetin. www.life- 50% increase risk of Demise. Complete B-Vitamins with B-12 Methylcobalamin, BUOrderInf enhancement.com/magazine/article/2428-pain- www.joshmitteldorf.scienceb Uridine, Prebiotic/Probiotic to Manage Inflammation o.action?tc= relief-starts-in-the-brain-blockade-of-tnf- log.com/2017/03/08/nf-kb- Factors Produced during Ingestion of some Choline Dense 34485&labC alpha-tumor-necrosis-factor-alpha-inhibits-the- beyond-inflammation/ Foods, Enzymes which metabolize these factors or ode=DLO br. infliximab, adalimumab, or etanercept each synthesize these factors as well as precursors to these inhibit TNF-Alpha. Aucubin from Chaste Tree factors, Water, Phosphatidyl-Monomethylethanolamine Berry. TNF Alpha is inhibited by Curcumin (Phosphatidylmonomethylethanolamine or PMME), from turmeric, Catechins from green tea, and Human Rubisco, Recombinant Rubisco, Rubisco Agonists Aucubin from plantain. Carahealth Website. or Rubisco Modulators, Polyacetylates, Phosphatidylethanolamine, Phosphatidylethanolamine Methyltransferase, Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table salt. Factor Indicative Information Wholistic Factors to Accompany Therapeutics Information Interleukins Cytokine Circumin. Lutein from Citrus Clinicians can begin Choline, Trimethylglycine, Folate/Methylfolate, Glutathione, Laboratory Bioflavonoids, Basil, Artichoke, with Interluekin 6 Probiotic/Prebiotic, Complete-B Vitamins, Omega-3 Fatty Acids, tests, Celery, Thyme, Peppermint, thresholds at 2.08 Whole Food Organic Vitamins, Complete Minerals, numerous Parsley, Green Pepper. pg/ml although the Flavonoid/Carotenoid/Phytochemical Supplement, Glandular Mix, interleukins. Pharmacological factors include levels of those with KAL SOD3 or other Antioxidant Mix with Catalase and Superoxide www.ltd.arupl Arcalyst, Dupixent, Kineret, the most optimal Dismutase, Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, ab.com/tests/p Stelara, Actemra, Cinqair, Taltz, health status should be Inhibitors of AP-1(x), including Citrus Fruit with Peelings/Rinds, ub/0051394 Nucala, Cosentyx, Ilaris, Kevzara, therapeutic goals as Inhibitors of SP-1(X), Management of Homocysteine, Management of Siliq, Simulect, Sylvant, Zenapx, well as analytic S-Adenosyl Homocysteine or S-Adenosyl Homocysteine inhibitors, and Zinbryta. thresholds. Reference, inhibitors of Inducible Nitric Oxide Synthase, Inhibitors of Uncouple www.drugs.com/drug- Am J Med, Volume Nitric Oxide Synthase and its Reactive Molecular Species (L-Arginine, class/interleukin-inhibitors.html. 1999, Number 106, Tetrahydrobiopterin, NADPH, Superoxide Dismutase, Catalase, Increased levels of Interluekin-6 Pages 506 to 512, Glutathione, Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, at are associated with an 364% 1999. Interluekin 1b Complete B-Vitamins with B-12 Methylcobalamin, Uridine, increased risk of demise in a is also important for Prebiotic/Probiotic to Manage Inflammation Factors Produced during study. DOI iNOS. Ingestion of some Choline Dense Foods, Enzymes which metabolize 10.1016/j.jfma.2017.02.002 these factors or synthesize these factors as well as precursors to these factors, Water, Phosphatidyl-Monomethylethanolamine (Phosphatidylmonomethylethanolamine or PMME), Human Rubisco, Recombinant Rubisco, Rubisco Agonists or Rubisco Modulators, Polyacetylates, Phosphatidylethanolamine, Phosphatidylethanolamine Methyltransferase, Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table salt. Factor Indicative Information Wholistic Factors to Accompany Therapeutics Information L-Lactate and Resting Lactate Analytically Significant Ranges Exhibited by Healthiest Patients Observed Choline, Trimethylglycine, Folate/Methylfolate, Glutathione, L-Lactic which is not in Practice. Between 100 and 50 Milligrams of Thiamine for two weeks. Probiotic/Prebiotic, Complete-B Vitamins, Omega-3 Fatty Acid. between 1.5 and Dichloroacetate. Potentially Methylene Blue. Plasma Exchange for Propofol Acids, Whole Food Organic Vitamins, Complete Minerals, 0.5 Micromoles Infusion Syndrome. Hemodialysis for Metformin Associated Lactic Flavonoid/Carotenoid/Phytochemical Supplement, per Liter. Acidosis. Carbicarb. Tromethamine. Sodium Bicarbonate NaHCO3. Glandular Mix, KAL SOD3 or other Antioxidant Mix with Peroxynitrite Vasopressors and Inotropes to assist in Oxygen availability. Catecholamines Catalase and Superoxide Dismutase, Choline Kinase can impair when acute Ischemia is not exhibited. Ringer’s Lactate and Plasma - Lyte to Inhibitors, Tyrosine Kinase Inhibitors, Inhibitors of AP-1(x), Cytochromes, avoid Acidosis but potentiates Alkalosis. Crystalloids and an Colloids for including Citrus Fruit with Peelings/Rinds, Inhibitors of SP- D – Lactate Intravascular Volume but not Hydroxyethyl Starch Solutions which are risky. 1(X), Management of Homocysteine, Management of S- Dehydrogenas Addressing empirical causality which can be any of the Super Indicators Adenosyl Homocysteine or S-Adenosyl Homocysteine e, Ferric Iron Presented here, Sepsis, Toxicity, Oncology, Pharmacological inhibitors, inhibitors of Inducible Nitric Oxide Synthase, to Ferrous Counterindications, including chelation, Antibiotics, Methylglyoxal Inhibitors of Uncouple Nitric Oxide Synthase and its Iron balance, Management, Microbe Management, etc. Information from Lactic Acidosis Reactive Molecular Species (L-Arginine, as well as Treatment and Management at Medscape.com’s emedicine area. A primary Tetrahydrobiopterin, NADPH, Superoxide Dismutase, Histidine, cause of Lactate increase or volatility is Anaerobic Glycolysis status in Catalase, Glutathione, Citrulline/Arginine/Ornithine), Tyrosine, which muscle tissue not actively being exercised or cellular entities NAD+, Hyaluronic Acid, Complete B-Vitamins with B-12 Tryptophan, generally have inhibited PEMT and inhibited Ethanolamine Kinase Pathway, Methylcobalamin, Uridine, Prebiotic/Probiotic to Manage Myoglobulin resulting in P53 that inhibits Pentose Phosphate synthesis of NADPH and Inflammation Factors Produced during Ingestion of some pervasive Nucleotides. DNA repair occurring in more than 1 Million instances in each Choline Dense Foods, Enzymes which metabolize these molecules. cellular entity each day becomes deprived of NADPH Redox and factors or synthesize these factors as well as precursors to Nucleotides as a result. DNA repair depletes NAD+ as PARP1 DNA Repair these factors, Water, Phosphatidyl-Monomethylethanolamine Signaling distributes NAD+ to produce gradients that recruit Nucleotides (Phosphatidylmonomethylethanolamine or PMME), Human and other repair factors, while Nucleotides are not adequately being Rubisco, Recombinant Rubisco, Rubisco Agonists or synthesized. This depletion of NAD+ and inability to replenish it quickly Rubisco Modulators, Polyacetylates, causes Pyruvate transformation to Lactate to occur because NADH is Phosphatidylethanolamine, Phosphatidylethanolamine consumed to produce deficient NAD+, although Pyruvate/Lactate balance Methyltransferase, Methyltetrahydrofolate Reductase, and Acetaldehyde/Ethanol participate in this balance. NAD+ Synthesis is Betaine Homocysteine Methyltransferase, Ancient Pink considered can occur in the concluding phase of Himalayan Sea Salt instead of Table salt. Factor Indicative Information Wholistic Factors to Accompany Therapeutics Information L-Lactate and www.emedicine.me Choline, N,N,N, Trimethylglycine, Folate, Vitamin B-12 Methylcobalamin, Choline, Trimethylglycine, Folate/Methylfolate, L-Lactic Acid. dscape.com/article/ Vitamin B-6, Niacin, other B Vitamins, Glutathione, Reduced Glutathione, Glutathione, Probiotic/Prebiotic, Complete-B 167027-overview. Cysteine, Histidine, and associated factors decrease P53 and supply the Vitamins, Omega-3 Fatty Acids, Whole Food Organic www.labtestsonl Arterial pH less Carbonate Buffering system with Cations, Anions and unpolarized factors. L Vitamins, Complete Minerals, ine.org/understa than 7.35 and Lactate and L Lactic Acid are typically balanced by Lactate Dehydrogenase. Flavonoid/Carotenoid/Phytochemical Supplement, nding/analytes/l Lactic Acid of any No Paralytic Status, Ischemia or other status intervention can be complete Glandular Mix, KAL SOD3 or other Antioxidant Mix actate/tab/test variety at 5 unless Neuroprotectants are provided, Reperfusion is assured, Paralytic Status with Catalase and Superoxide Dismutase, Choline Micromoles per is managed into conscious ranges, consciousness repression therapeutics are Kinase Inhibitors, Tyrosine Kinase Inhibitors, liter is consider removed ample regeneration duration is enabled, and ample directed activity Inhibitors of AP-1(x), including Citrus Fruit with Toxic or Septic to regenerate neurological capability has been instrumented. Other research Peelings/Rinds, Inhibitors of SP-1(X), Management of Shock, although observes that moderate levels of D Lactate and L Lactate result in higher Homocysteine, Management of S-Adenosyl Methylglyoxal molarity of D-Lactate and about 60% uretic clearance of D-Lactate with about Homocysteine or S-Adenosyl Homocysteine levels indicate 5% Uretic Clearance of L-Lactate. Higher molarity D/L Racemic infusion of inhibitors, inhibitors of Inducible Nitric Oxide Shock also. Lactic Lactic Acid produce up to 100% D-Latic Acid Clearance and up to 30% L- Synthase, Inhibitors of Uncouple Nitric Oxide Acidosis from Lactic Acid Clearance. However, D-Lactate at higher the 3 Micromoles per Synthase and its Reactive Molecular Species (L- Medscape Website. liter seems to impair L-Lactate clearance. D-lactate is a hidden cause of L- Arginine, Tetrahydrobiopterin, NADPH, Superoxide Typical pH is lactate and L-Lactic Acid as a Cause of Acidosis. PMID: 4010522. +. Dismutase, Catalase, Glutathione, between 7.45 and Methylene Blue converts Ferric Iron with a +3 Oxidation in which 3 Electrons Citrulline/Arginine/Ornithine), NAD+, Hyaluronic 7.35. have been acquired into Ferrous Iron with a +2 Oxidation status in which two Acid, Complete B-Vitamins with B-12 Electrons have been acquired. D-Lactate Dehydrogenase Bidirectionally Methylcobalamin, Uridine, Prebiotic/Probiotic to DOI transforms D-Lactate and 2 Ferricytochrome C to Pyruvate and 2 Manage Inflammation Factors Produced during 10.1016/j.annemerg Ferrocytochrome C while utilizing Flavin Adenine Dinucleotide. The reason Ingestion of some Choline Dense Foods, Enzymes med.2012.10.022 that Methylene Blue assists in L-Lactic Acidosis seems to be its management which metabolize these factors or synthesize these of D-Lactic Acid, with D-Lactic Acid as a hidden variable to its effectiveness. factors as well as precursors to these factors, Water, Management of D-Lactate can assists in management of L-Lactate. NAD+ can Phosphatidyl-Monomethylethanolamine prevent the continued production of L-Lactic Acid. Choline can introduce (Phosphatidylmonomethylethanolamine or PMME), Hydride or basic Influence to biophysiology without exhibition of free H-. L- Human Rubisco, Recombinant Rubisco, Rubisco Lactate indicates a %714 difference in potential demise between less than 2 Agonists or Rubisco Modulators, Polyacetylates, Micromoles per liter and more than 2 Micromoles per liter in the acute setting. Phosphatidylethanolamine, Phosphatidylethanolamine DOI 10.1016/j.annemergmed.2012.10.022. L – Lactate correlates to decrease Methyltransferase, Methyltetrahydrofolate Reductase, of potential for demise from 1.5 down to 1 when it is at ore below 5.3 Betaine Homocysteine Methyltransferase, Ancient Milligrams per Deciliter. Pink Himalayan Sea Salt instead of Table salt. Factor Indicative Information Wholistic Factors to Accompany Therapeutics Information D-Lactate and D Lactate at 3 D-Lactic Acid can be compartmentalized from other Energy and Choline, Trimethylglycine, Folate/Methylfolate, D-Lactic Acid Micromoles per liter Lactic Acid Metabolism, although the literature suggests otherwise Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, or more. D Lactate in some instances. It can be a perilous factor because it can Omega-3 Fatty Acids, Whole Food Organic Vitamins, Peroxynitrite not between 0.5 and 2 produce Acidosis or paralytic status and organ dysfunction while Complete Minerals, Flavonoid/Carotenoid/Phytochemical can impair Micromoles per Liter. not being widely tested for adequately. Acute circumstance Supplement, Glandular Mix, KAL SOD3 or other Cytochromes, D Lactate persistently at requires Parenteral or IV supplementation of Carbohydrate but not Antioxidant Mix with Catalase and Superoxide – Lactate two or above is Oral Carbohydrate obtainment. Intravenous Bicarbonate and Dismutase, Choline Kinase Inhibitors, Tyrosine Kinase Dehydrogenase, associated with All rehydration for Acidosis. Ringer’s Solutions exhibits D-Lactate Inhibitors, Inhibitors of AP-1(x), including Citrus Fruit Ferric Iron to Cause Adverse Health and should be avoided. Intravenous Thiamine. Oral Antibiotics, with Peelings/Rinds, Inhibitors of SP-1(X), Management Ferrous Iron statuses. Neurological particularly less easily absorbed Antibiotics that are effective for of Homocysteine, Management of S-Adenosyl balance, as well Problems, Acid Tolerant Bacteria, including Tetracycline 500 MG three Homocysteine or S-Adenosyl Homocysteine inhibitors, as Histidine, Aggressiveness, instances each day, Metronidazole, Clindamycin 300 MB three inhibitors of Inducible Nitric Oxide Synthase, Inhibitors Tyrosine, Detrimental Behavior. instances each day, Neomycin 500 MG three instances each day, of Uncouple Nitric Oxide Synthase and its Reactive Tryptophan, Oral Carbohydrate Vancomycin 125 MG four instances each day, and Kanamycin. Molecular Species (L-Arginine, Tetrahydrobiopterin, Myoglobulin Challenge. Acute D Lactate requires Carbohydrate obtainment abatement, NADPH, Superoxide Dismutase, Catalase, Glutathione, pervasive Rehydration, Antibiotics. Yogurt, Sauerkraut and Pickled Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, molecules. Vegetables can have higher levels of D-lactate. Adequate Complete B-Vitamins with B-12 Methylcobalamin, Hydration is required. oley.org/?page=DLacticAcidosis. Sodium Uridine, Prebiotic/Probiotic to Manage Inflammation Bicarbonate is useful although risky. Peritoneal Dialysis and Factors Produced during Ingestion of some Choline Dense Hemodialysis are useful. Peritoneal Dialysis with Bicarbonate Foods, Enzymes which metabolize these factors or Dialysate provides a useful physiological augmentation of the synthesize these factors as well as precursors to these Carbonate Buffering System. Methylene Blue has been suggested factors, Water, Phosphatidyl-Monomethylethanolamine as having less utility than Sodium Nitroprusside which also (Phosphatidylmonomethylethanolamine or PMME), alleviates regional Hypoperfusion. Insulin Therapy is effective for Human Rubisco, Recombinant Rubisco, Rubisco Agonists Phenformin Associated Acidosis. Dichloroacetate activates or Rubisco Modulators, Polyacetylates, Pyruvate Dehydrogenase, thereby being useful. Phosphatidylethanolamine, Phosphatidylethanolamine www.ncbi.nlm.nih.gov/pubmed/7020090/. Oncology, Toxicity, Methyltransferase, Methyltetrahydrofolate Reductase, Pulmonary, Circulatory or Hemoglobin Transfer impairment Betaine Homocysteine Methyltransferase, Ancient Pink results in type A Lactic Acidosis. Himalayan Sea Salt instead of Table salt. Factor Indicative Information Information Wholistic Factors to Accompany Therapeutics D-Lactate Serum or The clinical indication is that ATP is required to be produced without Oxygen, Choline, Trimethylglycine, Folate/Methylfolate, and D- Hematopoietic Tests which is similar to Anaerobic Glycolysis, although the literature pervasively Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, Lactic Acid can be complex underconsiders uncoupled and Inducible Nitric Oxide Synthase as well as Omega-3 Fatty Acids, Whole Food Organic Vitamins, because it should Arachidonic Acid and other Reactive Oxygen Species in such regard, Complete Minerals, Flavonoid/Carotenoid/Phytochemical www.nslijla coincide with www.ncbi.nlm.nih.gov/pubmed/7020090/, Short Bowel Syndrome can result Supplement, Glandular Mix, KAL SOD3 or other b.testcatalo Symptoms. Arterial pH in D-Lactic Acidosis. Article at Electrolyte & Blood Pressure Volume 4, Pages Antioxidant Mix with Catalase and Superoxide g.org/show/ less than 7.35 and 53-56, 2006. D-Lactic Acid persists as a low Dalton Molecular factor until Dismutase, Choline Kinase Inhibitors, Tyrosine Kinase D-LACT Lactic Acid of any typically excreted unchanged in Uretic Output. Other research observes that Inhibitors, Inhibitors of AP-1(x), including Citrus Fruit variety at 5 moderate levels of D Lactate and L-Lactate result in higher molarity of D- with Peelings/Rinds, Inhibitors of SP-1(X), Management Micromoles per liter is Lactate and about 60% uretic clearance of D-Lactate with about 5% Uretic of Homocysteine, Management of S-Adenosyl consider Toxic or Clearance of L-Lactate. Higher molarity D/L Racemic infusion of Lactic Acid Homocysteine or S-Adenosyl Homocysteine inhibitors, Septic Shock, although produce up to 100% D-Latic Acid Clearance and up to 30% L-Lactic Acid inhibitors of Inducible Nitric Oxide Synthase, Inhibitors Methylglyoxal levels Clearance. However, D-Lactate at higher the 3 Micromoles per liter seems to of Uncouple Nitric Oxide Synthase and its Reactive indicate Shock also. impair L-Lactate reabsorption and clearance. D-lactate is a hidden cause of L- Molecular Species (L-Arginine, Tetrahydrobiopterin, Lactic Acidosis from lactate and L-Lactic Acid increases as a Cause of Acidosis. L-Lactate NADPH, Superoxide Dismutase, Catalase, Glutathione, Medscape Website. increases also impairs both Clearance and Reabsorption of L-Lactate. PMID: Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, Typical pH is from 4010522 These clearly indicate that compartmentalized L and D Chiral Complete B-Vitamins with B-12 Methylcobalamin, 7.55 to 7.35. Rapid Lactate compete for NAD+. Methylene Blue converts Ferric Iron with a +3 Uridine, Prebiotic/Probiotic to Manage Inflammation decreases in D Lactate Oxidation in which 3 Electrons have been acquired to Ferrous Iron with a +2 Factors Produced during Ingestion of some Choline indicate risk, lower Oxidation status in which two Electrons have been acquired. D-Lactate Dense Foods, Enzymes which metabolize these factors or levels in incipient days Dehydrogenase Bidirectionally transforms D-Lactate and 2 Ferricytochrome C synthesize these factors as well as precursors to these of admittance to care with D-Lactate and 2 Ferrocytochrome C while utilizing Flavin Adenine factors, Water, Phosphatidyl-Monomethylethanolamine indicates better Dinucleotide. The reason that Methylene Blue assists in L-Lactic Acidosis (Phosphatidylmonomethylethanolamine or PMME), prognosis independent seems to be its management of D-Lactic Acid, with D-Lactic Acid as a hidden Human Rubisco, Recombinant Rubisco, Rubisco of L-Lactate Levels. variable to its effectiveness. Management of L-Lactate can assist in D-Lactate Agonists or Rubisco Modulators, Polyacetylates, DOI Management. Choline can introduce Hydride or basic Influence to Phosphatidylethanolamine, Phosphatidylethanolamine 10.1515/CCLM.2006.0 biophysiology without exhibition of free H-. D – Lactate is also associated Methyltransferase, Methyltetrahydrofolate Reductase, 86 with increased intraabdominal pressurization characteristics. Digestive Betaine Homocysteine Methyltransferase, Ancient Pink Diseases and Sciences, Volume 51, Issue 12, Page 2400, December, 2006. Himalayan Sea Salt instead of Table salt. Factor Indicative Information Information Wholistic Factors to Accompany Therapeutics Methylglyoxal. General Methylglyoxal outperforms Analytically Significant Ranges Exhibited by Choline, Trimethylglycine, Folate/Methylfolate, Glutathione, metabolic panel. Procalcitonin, C-Reactive Healthiest Patients Observed in Practice. Probiotic/Prebiotic, Complete-B Vitamins, Omega-3 Fatty Protein, Soluble CD14, Pyridoxamine inhibits Methylglyoxal Glycation, Acids, Whole Food Organic Vitamins, Complete Minerals, Interleukin 6, for Septic Shock DOI 10.1155/2013/690650. Aldose reductase Flavonoid/Carotenoid/Phytochemical Supplement, Glandular Diagnosis. inhibitors decrease the concentration of Mix, KAL SOD3 or other Antioxidant Mix with Catalase and www.ccforum.biomedcentral.co methylglyoxal. Aminoguanidine Scavenges Superoxide Dismutase, Choline Kinase Inhibitors, Tyrosine m/articles/10.1186/s13054-014- Methylglyoxal. L-arginine scavenges Kinase Inhibitors, Inhibitors of AP-1(x), including Citrus Fruit 0683-x Digital Object methylglyoxal. Digital Object Identifier. with Peelings/Rinds, Inhibitors of SP-1(X), Management of Identifier 10.1186/s13054-014- 10.1007/BF00808119. Gallic Factors and Homocysteine, Management of S-Adenosyl Homocysteine or 0683-x Aortic Plasticity Phenolic Factors inhibit Methylglyoxal S-Adenosyl Homocysteine inhibitors, inhibitors of Inducible impairment is correlated with Glycation. Diagnostic Assay. Nitric Oxide Synthase, Inhibitors of Uncouple Nitric Oxide all cause demise. www.mybiosource.com/prods/ELISA- Synthase and its Reactive Molecular Species (L-Arginine, Methylglyoxal is associated Kit/Human/Methylglyoxal/MG/datasheet.php?pro Tetrahydrobiopterin, NADPH, Superoxide Dismutase, with %99 increase in adverse ducts_id=756333 Methylglyoxal activates Catalase, Glutathione, Citrulline/Arginine/Ornithine), NAD+, health events and %54 increase MAPK and Cyclically potentiates Choline Kinase Hyaluronic Acid, Complete B-Vitamins with B-12 in demise in a particular study. by potentiating iNOS which upregulates Choline Methylcobalamin, Uridine, Prebiotic/Probiotic to Manage Digital Objective Identifier. Kinase. Inflammation Factors Produced during Ingestion of some 10.2337/db16-1578 www.geresdengle.com/blogs/news/86835265- Choline Dense Foods, Enzymes which metabolize these Sulforaphane, L-arginine, sulforaphane-inhibiting-glycation-new-target-for- factors or synthesize these factors as well as precursors to these manage Methylglyoxal while alzheimers-disease Sulforaphane is therapeutic factors, Water, Phosphatidyl-Monomethylethanolamine Pyridoxamine alleviates for Methylglyoxal. Relevant Therapeutics other (Phosphatidylmonomethylethanolamine or PMME), Human Methylglyoxal inhibition of than presented here may also be useful. Some Rubisco, Recombinant Rubisco, Rubisco Agonists or Rubisco JNK and AKT survival oncology is inhibited by Methylglyoxal although Modulators, Polyacetylates, Phosphatidylethanolamine, signaling during Ischemia. Methylglyoxal is a principal Glycation End Phosphatidylethanolamine Methyltransferase, 10.1021/acs.chemrestox.5b0006 Product, Carbonylation, Sepsis and Toxic Shock Methyltetrahydrofolate Reductase, Betaine Homocysteine 7 pathway. Inhibition of its Glycation Potential is Methyltransferase, Ancient Pink Himalayan Sea Salt instead of best. www.sbir.gov/sbirsearch/detail/677768. Table salt. Factor Indicative Information Information Wholistic Factors to Accompany Therapeutics Hyperoxaluri Urine test for Hyperoxaluria. Analytically Significant Ranges Exhibited by Choline, Trimethylglycine, Folate/Methylfolate, Glutathione, a. Urine www.mayomedicallaboratories. Healthiest Patients Observed in Practice. Probiotic/Prebiotic, Complete-B Vitamins, Omega-3 Fatty Acids, Panel. com/test- Magnesium Citrate. Calcium Citrate. Whole Food Organic Vitamins, Complete Minerals, Genotype. catalog/Clinical+and+Interpreti www.lowoxalate.info. Kidney Stuff by Golden Flavonoid/Carotenoid/Phytochemical Supplement, Glandular Mix, ve/86213. Genetic test for Standards. Essential Multi-Glandular by KAL SOD3 or other Antioxidant Mix with Catalase and Superoxide Hyperoxaluria Traditionalfoods.org. Cholestyramine integrates Dismutase, Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, Genotype/phenotype with Oxalate in the Digestive Pathway for Ingested Inhibitors of AP-1(x), including Citrus Fruit with Peelings/Rinds, www.hopkinsmedicine.org/dna Oxalates, but this decreases Lanoxin and Warfarin Inhibitors of SP-1(X), Management of Homocysteine, Management diagnostic/tests/tests/primary- Pharmacokinetics. of S-Adenosyl Homocysteine or S-Adenosyl Homocysteine hyperoxaluria-type-1-test www.umm.edu/health/medical/reports/articles/kidn inhibitors, inhibitors of Inducible Nitric Oxide Synthase, Inhibitors Typically levels of Hyaluronic ey-stones. The literature suggest the threshold for of Uncouple Nitric Oxide Synthase and its Reactive Molecular Acid are presented a 0.24 Hyperoxaluria Diagnosis is 30 MG of Oxalate Species (L-Arginine, Tetrahydrobiopterin, NADPH, Superoxide Micromoles per Liter in Secreted in Urine for each Gram of Excreted Dismutase, Catalase, Glutathione, Citrulline/Arginine/Ornithine), Cerebrospinal Fluid. Creatinine. NAD+, Hyaluronic Acid, Complete B-Vitamins with B-12 Hyperoxularia indicated by www.emedicine.medscape.com/article/444683- Methylcobalamin, Uridine, Prebiotic/Probiotic to Manage eGFR, ml/min per 1.73 m2 overview Relevant Therapeutics. Inflammation Factors Produced during Ingestion of some Choline At or above the Median www.emedicine.medscape.com/article/444683- Dense Foods, Enzymes which metabolize these factors or Quaritle 73.0 with a stronger overview Pyridoxine is therapeutic for synthesize these factors as well as precursors to these factors, Water, diagnostic threshold at or above Hyperoxaluria with more responsiveness among Phosphatidyl-Monomethylethanolamine 56.4 and with an optimal level women. Vitamin E therapy. DOI 10.1111/j.1464- (Phosphatidylmonomethylethanolamine or PMME), Human at about 97.5, results in an up to 410X.2005.05579.x. PEMT suppression, Rubisco, Recombinant Rubisco, Rubisco Agonists or Rubisco 4.2 to 1 improvement in Hyaluronic Acid Pathway suppression, and Modulators, Polyacetylates, Phosphatidylethanolamine, Adverse Health Status. DOI deficiency results in inhibited synthesis of Phosphatidylethanolamine Methyltransferase, 10.2215/CJN.02810315. Hyaluronic Acid. Magnesium Supplements and Methyltetrahydrofolate Reductase, Betaine Homocysteine drinking increased levels of water are therapeutic Methyltransferase, Ancient Pink Himalayan Sea Salt instead of for Hyperoxaluria. An inhibitor of Lactate Table salt. Dehydrogenase only in the Hepatic Organ such as by DCR-PHXC, although the effect to Lactate Dehydrogenase Synthesis of NAD+ from NADH and synthesis of Pyruvate from Lactate has to be considered therapeutically. Factor Indicative Information Wholistic Factors to Accompany Therapeutics Information SP-1 SP-1 promotes (HIV Also requires uncoupled nitric oxide synthase, Choline, Trimethylglycine, Folate/Methylfolate, Glutathione, Transactivator immortality and Inducible Nitric Oxide Synthase, Uncoupling of Probiotic/Prebiotic, Complete-B Vitamins, Omega-3 Fatty Acids, Protein 1. survival of cellular Inducible Nitric Oxide Synthase and TPA/PMA, such Whole Food Organic Vitamins, Complete Minerals, Oncology Gene entities because it that therapeutic inhibiting all of these could be the most Flavonoid/Carotenoid/Phytochemical Supplement, Glandular Expression. upregulates Choline effective HIV Therapeutic produced) SP-1 inhibits Mix, KAL SOD3 or other Antioxidant Mix with Catalase and Assay of both Kinase. PEMT and upregulates aspects of the Choline Kinase Superoxide Dismutase, Choline Kinase Inhibitors, Tyrosine Kinase SP1 and SP3 SP-1/SP-3 Pathway. SP-1 is include and required in pervasive Inhibitors, Inhibitors of AP-1(x), including Citrus Fruit with management is Diagnostic Assay Microbial and viral pathology, similarly to AP-1, NF kB Peelings/Rinds, Inhibitors of SP-1(X), Management of recommended Kit and iNOS. Inhibitors of SP-1, AP-1 or NF kB, as well as Homocysteine, Management of S-Adenosyl Homocysteine or S- for Oncology or www.abcam.com/ps inhibitors Choline Kinase Kinase transform microbial Adenosyl Homocysteine inhibitors, inhibitors of Inducible Nitric other health /products/207/ab207 Pathology. SP-1 stimulates Telomerase activity which is Oxide Synthase, Inhibitors of Uncouple Nitric Oxide Synthase and conditions. 227/documents/ab2 known to confer immortality to multipole cellular its Reactive Molecular Species (L-Arginine, Tetrahydrobiopterin, SP1 activates 07227%20Sp1- Phenotypes, but is not the only way in which Telomerase NADPH, Superoxide Dismutase, Catalase, Glutathione, Topoisomerase Sp3%20Transcriptio is activated. Telomerase does not require upregulation Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, II alpha n%20Factor%20Ass for Pathology, it can become phosphorylated by AKT Complete B-Vitamins with B-12 Methylcobalamin, Uridine, although SP3 ay%20Kit%20v1%2 Protein Kinase for increased Catalytic Activity. AKT Prebiotic/Probiotic to Manage Inflammation Factors Produced dominantly 0(website).pdf inhibition is potentiated by inhibitors of AP-1, SP-1, during Ingestion of some Choline Dense Foods, Enzymes which inactivates it, Curcumin is an SP1 TPA/PMA, and inflammation inhibition generally. metabolize these factors or synthesize these factors as well as suppressing the inhibitor and iNOS Mithramycin. 10.1523/JNEUROSCI.0710-11.2011. precursors to these factors, Water, Phosphatidyl- benefit of inhibitor are Tolfenamic Acid which has therapeutic effect along with Monomethylethanolamine (Phosphatidylmonomethylethanolamine Doxorubicin. therapeutic for HPV, Cisplatin. 10.1007/s13277-016-5290-9. SP1 activates or PMME), Human Rubisco, Recombinant Rubisco, Rubisco Inhibiting SP3 HIV and other Viral Hepatocyte Growth Factor while SP3 inhibits Hepatocyte Agonists or Rubisco Modulators, Polyacetylates, may be Pathology, Growth Factor when SP1 is not adequately bioavailable. Phosphatidylethanolamine, Phosphatidylethanolamine essential for including Oncology. SP-1 is ugregulated in numerous Microbial, Oncological Methyltransferase, Methyltetrahydrofolate Reductase, Betaine Doxorubicin and other conditions including being a stimulator of Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Resistant Midkine expression which is increased in numerous Salt instead of Table salt. Oncology. DOI Gliomas. DOI 10.1091/mbc.E14-10-1443 10.1186/1471- 2199-8-36. Factor Indicative Information Wholistic Factors to Accompany Therapeutics Information SP-1 Transactivator SP3 is SP1 and SP3, SP-1 and SP-3, are cooperative modulators of CPT Choline, Trimethylglycine, Folate/Methylfolate, Glutathione, Protein 1. inhibited by Phosphocholine Cytidylyltransferase Alpha with reversible roles Probiotic/Prebiotic, Complete-B Vitamins, Omega-3 Fatty Oncology Gene Mythramycin. in Transcription activation in the Promoter Region of the Ctpct Acids, Whole Food Organic Vitamins, Complete Minerals, Expression. PMCID Gene, while SP2/SP-2 is a weak Transcriptional activator. DOI Flavonoid/Carotenoid/Phytochemical Supplement, Glandular Assay of both SP1 PMC3717375. 10.1128/MCB.01828-08. J Lipid Res, Volume 41. Number Pages Mix, KAL SOD3 or other Antioxidant Mix with Catalase and and SP3 is SP-1 is 583 to 594. Protein Kinase C activates SP-1, through TPA/PMA, Superoxide Dismutase, Choline Kinase Inhibitors, Tyrosine recommended for inhibited by cyclically since SP-1 also activates TPA/PMA, but SP-1 can Kinase Inhibitors, Inhibitors of AP-1(x), including Citrus Oncology or other Metformin activate Protein Kinase C through these same mechanism. SP-1 Fruit with Peelings/Rinds, Inhibitors of SP-1(X), Management health conditions. and the inhibits PEMT. SP-1 upregulates Choline Kinase. SP-1 of Homocysteine, Management of S-Adenosyl Homocysteine SP1 activates Steroidal upregulates Telomerase. Sp-1 or SP1 is considered a factor or S-Adenosyl Homocysteine inhibitors, inhibitors of Topoisomerase II Lactone expressed in correlation with the 8 essential causal Factors in Inducible Nitric Oxide Synthase, Inhibitors of Uncouple alpha although SP3 Withaferin A Oncology. These 8 essential factors are characterized as Nitric Oxide Synthase and its Reactive Molecular Species (L- dominantly from Withania Sustained Proliferative Signaling, Replicative Immortality, Arginine, Tetrahydrobiopterin, NADPH, Superoxide inactivates it, Somnifera, Resilience to Necrosis/Apoptosis, Resistance, Angiogenesis Dismutase, Catalase, Glutathione, suppressing the Ashwagandha, Stimulation, Avoidance of Immunological enabled Deterioration, Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, benefit of Circumin, and Invasion and Metastasis, as well as unregulated Cellular Complete B-Vitamins with B-12 Methylcobalamin, Uridine, Doxorubicin. Benfotiamine. Energetics. DOI 10.1111/febs.13148. Kruppel – Associated Zinc Prebiotic/Probiotic to Manage Inflammation Factors Produced Inhibiting SP3 may HIV-1 TAT Finger Protein AP-2rep (KLF12) competes with and inhibits SP-1 during Ingestion of some Choline Dense Foods, Enzymes be essential for only induces transactivation in models of Ovarian Oncology. DOI which metabolize these factors or synthesize these factors as Doxorubicin enough P73 10.1186/s12943-017-0582-2. Similarly, P53 competes with well as precursors to these factors, Water, Phosphatidyl- Resistant for viral SP1/SP – 1 at the SP -1 Promoter Region in HIV LTR Sequences Monomethylethanolamine Oncology. DOI transcription and TATA Box Protein Promoter Regions, suggesting that SP-1 is (Phosphatidylmonomethylethanolamine or PMME), Human 10.1186/1471- to occur when a feature for Pathogenic Aerobic Glycolysis and impaired P53 Rubisco, Recombinant Rubisco, Rubisco Agonists or Rubisco 2199-8-36. SP-1 is activity. PMID 8207805. Gold is among the Divalent Metal Ions Modulators, Polyacetylates, Phosphatidylethanolamine, expressed. which can enable PEMT function. DOI 10.1038/nchem.2836 Phosphatidylethanolamine Methyltransferase, Myrrh and Frankincense inhibit Cyclooxygenase , CFOS and Methyltetrahydrofolate Reductase, Betaine Homocysteine CJUN, thereby also inhibiting activation of AP1 and inhibiting Methyltransferase, Ancient Pink Himalayan Sea Salt instead activation of SP1. DOI 10.1038/srep13668. of Table salt. Factor Indicative Information Wholistic Factors to Accompany Therapeutics Information Hyaluronic Extracellular Hyaluronic Acid Supplements. Relevant Therapeutics. Choline, Trimethylglycine, Folate/Methylfolate, Glutathione, Acid. Matrix, Glucosamine. D-Glucaronic Acid. N Hyaluronic Acid can be Probiotic/Prebiotic, Complete-B Vitamins, Omega-3 Fatty Acids, Connective Acetyl-O-Glucosamine. The of substantial Whole Food Organic Vitamins, Complete Minerals, Tissue and literature indicates that Glucosamine Neurological, tissue and Flavonoid/Carotenoid/Phytochemical Supplement, Glandular Mix, Neurological is safe at 500 MG three times per day regeneration benefit KAL SOD3 or other Antioxidant Mix with Catalase and Superoxide deterioration or or lower for diabetics. DOI when accompanied by Dismutase, Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, glomerulization. 10.2337/diacare.26.6.1941. choline pathway Inhibitors of AP-1(x), including Citrus Fruit with Peelings/Rinds, Hyaluronic Acid Hyaluronic acid is essential to supplementation. Inhibitors of SP-1(X), Management of Homocysteine, Management Assay. embryonic Scarless wound healing Hyaluronic acid inhibits of S-Adenosyl Homocysteine or S-Adenosyl Homocysteine www.questdiagn and its decrease along with DHA and Platelet Function during inhibitors, inhibitors of Inducible Nitric Oxide Synthase, Inhibitors ostics.com/testce EPA is known to describe differences Gestational of Uncouple Nitric Oxide Synthase and its Reactive Molecular nter/BUOrderInf the ability to Regenerate Anatomy Development allowing Species (L-Arginine, Tetrahydrobiopterin, NADPH, Superoxide o.action?tc=1948 among Mammals. Fibronectin to be guided Dismutase, Catalase, Glutathione, Citrulline/Arginine/Ornithine), 0X&labCode=Q www.surgerysupplements.com/glucos in development and NAD+, Hyaluronic Acid, Complete B-Vitamins with B-12 TE amine-may-aid-the-surgical-healing- repair according to the Methylcobalamin, Uridine, Prebiotic/Probiotic to Manage process/ Lymphocytes may be Gastrulation Program. Inflammation Factors Produced during Ingestion of some Choline unable to adhere to Hyaluronic Acid, Reference, Journal of Dense Foods, Enzymes which metabolize these factors or thereby decreasing inflammation, and Pediatric Surgery, synthesize these factors as well as precursors to these factors, preventing Lymphocytes from Volume 32, Number 7, Water, Phosphatidyl-Monomethylethanolamine activating Lymphocyte receptors that Pages 1037 to 1040, (Phosphatidylmonomethylethanolamine or PMME), Human would inhibit PEMT activity through July, 1997. Rubisco, Recombinant Rubisco, Rubisco Agonists or Rubisco MAPK, PI3K, AKT, cFOS, cJUN Modulators, Polyacetylates, Phosphatidylethanolamine, signaling. Phosphatidylethanolamine Methyltransferase, Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table salt. Factor Indicator, Primary Information Wholistic Factors to Accompany Therapeutics

Metabolic Alkalosis. Hypoventilation is www.emedicine.medscape.com/article/242975-treatment. Choline, Trimethylglycine, Folate/Methylfolate, Glutathione, Metabolic Acidosis is considered typical. Alkalosis with Ph more than 7.55 exhibits 40 percent risk of Probiotic/Prebiotic, Complete-B Vitamins, Omega-3 Fatty Acids, presented in Lactate Generally, demise and 7.65 is correlated to a 80 percent risk of abated Whole Food Organic Vitamins, Complete Minerals, Metabolism. impaired PEMT vital being. Urine CL less than 25 mEq/L is typically Flavonoid/Carotenoid/Phytochemical Supplement, Glandular Mix, availability associated with Regurgitation, Diuretics, Posthypercapnia, KAL SOD3 or other Antioxidant Mix with Catalase and Superoxide The literature impairs Cystic Fibrosis or Low Chloride obtainment whereas Cl Dismutase, Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, suggests that Glycolysis, above 40 mEQ/L is typically considered to occur from Inhibitors of AP-1(x), including Citrus Fruit with Peelings/Rinds, metabolic acidosis Pentose Phosphate Primary Mineralocorticoid Excess, Barrter’s or Gitelman’s Inhibitors of SP-1(X), Management of Homocysteine, Management without renal Pathway and Syndrome, Extreme Hypokalemia with K < 2.0, or Exogenous of S-Adenosyl Homocysteine or S-Adenosyl Homocysteine impairment is Krebs cycle Alkali Load. Chloride depletion Alkalosis is suggested to be inhibitors, inhibitors of Inducible Nitric Oxide Synthase, Inhibitors typically resultant of performance as alleviated by Cl- fluid along with NA+ or Choline. DOI of Uncouple Nitric Oxide Synthase and its Reactive Molecular high anion Gap, buffering and 10.1681/ASN.2011070720 Species (L-Arginine, Tetrahydrobiopterin, NADPH, Superoxide particularly resultant manage Phosphatidylmonomethylethanolamine, the intermediate of Dismutase, Catalase, Glutathione, Citrulline/Arginine/Ornithine), of Lactic Acid or capabilities for PEMT pathway, scavenges H2S and Co2, producing HS and NAD+, Hyaluronic Acid, Complete B-Vitamins with B-12 Ketoacidosis, both of systemic pH. HCO3, while Glycolysis scavenges HCO3- with ATP to Methylcobalamin, Uridine, Prebiotic/Probiotic to Manage which are managed produce Oxalate and scavenges CO2 toward fatty acid Inflammation Factors Produced during Ingestion of some Choline by optimal Pentose synthesis. Cysteine and Methionine are produce to assist in Dense Foods, Enzymes which metabolize these factors or synthesize Phosphate/Glycolysis Carbonate Buffering by the PEMT, Folate/Methionine these factors as well as precursors to these factors, Water, /Krebs pathways Synthase , BHMT/Methionine pathways. These suggest Phosphatidyl-Monomethylethanolamine when P53 is not PEMT enables management of Cations and Anions. (Phosphatidylmonomethylethanolamine or PMME), Human Rubisco, inhibiting these from PEMT/Choline/Phospholipid Pathways may be essential for Recombinant Rubisco, Rubisco Agonists or Rubisco Modulators, PEMT inadequacy, Alkalosis/Acidosis. PMID 16277723 Metabolic Acidosis Polyacetylates, Phosphatidylethanolamine, thus relevant for occurs when pH moves below 7.35 whereas pH above 7.45 is Phosphatidylethanolamine Methyltransferase, Alkalosis also. considered alkalosis in some of the literature. Below 7.2 and Methyltetrahydrofolate Reductase, Betaine Homocysteine above 7.5 introduces risk of paralytic status. Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table salt. Factor Indicator, Primary Information Wholistic Factors to Accompany Therapeutics Metabolic pH above 7.4 or Arterial Carbon Dioxide Tension is considered to increase 0.5 Choline, Trimethylglycine, Folate/Methylfolate, Glutathione, Alkalosis. above 7.45 Primarily to 0.7 Hg for each Meq/L increase in Plasma Bicarbonate Probiotic/Prebiotic, Complete-B Vitamins, Omega-3 Fatty Acids, Metabolic considered to occur molarity, such that a lag in this ratio can produce an imbalance Whole Food Organic Vitamins, Complete Minerals, Acidosis is resultant of HCO#- in Acidity and Alkalinity. Alkalosis and Acidosis can exist Flavonoid/Carotenoid/Phytochemical Supplement, Glandular Mix, presented in increase in serum or together at once. Respiratory and Anatomical pH are KAL SOD3 or other Antioxidant Mix with Catalase and Superoxide Lactate inadequate H+. associated but not always assured to be precisely the same. Dismutase, Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, Metabolism. Elevated HCO3- particularly more than 35 mEq/L is most Inhibitors of AP-1(x), including Citrus Fruit with Peelings/Rinds, indicative. Antacid ingestion can contributed to Metabolic Inhibitors of SP-1(X), Management of Homocysteine, Management Acidosis. Calcium, aluminum, along with base hydroxide, or of S-Adenosyl Homocysteine or S-Adenosyl Homocysteine carbonate, result in buffering of Hydrogen Ions in the inhibitors, inhibitors of Inducible Nitric Oxide Synthase, Inhibitors Stomach, balancing occurs in excretion into the stool. Saline of Uncouple Nitric Oxide Synthase and its Reactive Molecular is considered therapeutic, as are H+ inhibitors, PPIs with Species (L-Arginine, Tetrahydrobiopterin, NADPH, Superoxide Regurgitation, abated Diuretics, HCl or NH4Cl for Dismutase, Catalase, Glutathione, Citrulline/Arginine/Ornithine), Emergencies, Hemodialysis and Acetazolamide associated NAD+, Hyaluronic Acid, Complete B-Vitamins with B-12 with Chronic Cardiac Conditions. Saline unresponsive Methylcobalamin, Uridine, Prebiotic/Probiotic to Manage Alkalosis can be therapeutically affected with excision of Inflammation Factors Produced during Ingestion of some Choline neoplasm producing mineralocorticoids, Ace inhibitor, abated Dense Foods, Enzymes which metabolize these factors or synthesize Steroid usage, inhibition of Aldosterone, potassium repletion. these factors as well as precursors to these factors, Water, HCl presents a risk of Hemolysis. The literature pervasively Phosphatidyl-Monomethylethanolamine suggests managing underlying causality in Acidosis or (Phosphatidylmonomethylethanolamine or PMME), Human Rubisco, Alkalosis conditions and these recommendations are intended Recombinant Rubisco, Rubisco Agonists or Rubisco Modulators, to assist in understanding incipient causality and intended to Polyacetylates, Phosphatidylethanolamine, assist with therapies with which clinicians may already be Phosphatidylethanolamine Methyltransferase, familiar with and experienced with. Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table salt. Factor Indicator, Primary Information Wholistic Factors to Accompany Therapeutics C-Reactive Increased levels of C – Reactive Analytically Significant Ranges Exhibited by Healthiest Patients Choline, Trimethylglycine, Folate/Methylfolate, Protein. High Protein have been observed to Observed in Practice are recommended to be included for use. Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, Sensitivity C produce a 231 Percent increased Atorvastatin inhibits C-Reactive Protein enabled Metalloproteinase Omega-3 Fatty Acids, Whole Food Organic Vitamins, Reactive Protein risk of Demise in a Study. DOI: Synthesis and Tissue Inhibitor TIMP-1 Synthesis. 10.1007/s11010-009- Complete Minerals, Assay. 10.1016/j.jfma.2017.02.002 0340-x. C-Reactive Protein requires FCYRIIB activation by FCY and Flavonoid/Carotenoid/Phytochemical Supplement, Clinicians can begin with C- Protein Phosphatase A2 PPA2 to Uncouple Nitric Oxide Synthase. Glandular Mix, KAL SOD3 or other Antioxidant Mix www.mayoclinic. reactive Protein thresholds at Okadaic Acid from Dinoflagellates and Calyculin A inhibit Protein with Catalase and Superoxide Dismutase, Choline Kinase org/tests- 1.57 mg/Liter although the Phosphatase A2 while Okadaic Acid Inhibits C-reactive Proteins Inhibitors, Tyrosine Kinase Inhibitors, Inhibitors of AP- procedures/c- levels of those with the most Vasoconstrictive eNOS impairing activity. Vitamin C, Circumin, 1(x), including Citrus Fruit with Peelings/Rinds, reactive- optimal health status should be Magnesium, Omega-7, Vitamin D each depotentiate C-Reactive Protein. Inhibitors of SP-1(X), Management of Homocysteine, protein/basics/def therapeutic goals as well as www.drhoffman.com/article/12-natural-ways-to-protect-your-heart-and- Management of S-Adenosyl Homocysteine or S- inition/PRC- analytic thresholds. Reference, lower-your-crp/. Ginger, Onions, Montmorency Cherry, Balaton or Tart Adenosyl Homocysteine inhibitors, inhibitors of 20014480 Am J Med, Volume 1999, tasting Cherry. Vitamin E, Coenzyme Q10, Omega-3, Astaxanthin. Inducible Nitric Oxide Synthase, Inhibitors of Uncouple Number 106, Pages 506 to 512, www.naturalsociety.com/4-must-foods-reducing-inflammation-naturally/ Nitric Oxide Synthase and its Reactive Molecular www.cls.testcatal 1999. C-reactive Protein is Subacute levels of C – Reactive protein, ranging from 1 to 10 mg/L Species (L-Arginine, Tetrahydrobiopterin, NADPH, og.org/show/CRP correlated with and causal to correlate to 7.3 percent increase for each 1 mg/L increase whereas Superoxide Dismutase, Catalase, Glutathione, -1 clotting, generation of oxygen change from typical regarded as less than or equal to 3 mg/L to clinical Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, radicals, increase in the regarded as more than 3 mg/L there was a %700 percent increase in Complete B-Vitamins with B-12 Methylcobalamin, expression of adhesion potential for Demise. DOI 10.1136/hrt.2007.118794 Inhibitors or Uridine, Prebiotic/Probiotic to Manage Inflammation molecules and plasminogen Modulators or C-Reactive Protein or Apoptosis/Necrosis Inhibitors such Factors Produced during Ingestion of some Choline activator inhibitor-1, plaque as Omega-3, Choline, and Wholistic Factors. CRP-i2 and C-Reactive Dense Foods, Enzymes which metabolize these factors or destabilization. NAD+ depletion protein antisense oligonucleotide (ASO) inhibit C-Reactive Protein. C- synthesize these factors as well as precursors to these occurs also resultant of reactive protein is inhibited by Cyclooxygenase Inhibitors (Aspirin, factors, Water, Phosphatidyl-Monomethylethanolamine inadequate choline, inhibited Rofecoxib(removed from market), Celecoxib), Platelet Adhesion (Phosphatidylmonomethylethanolamine or PMME), PEMT, PEMT2 in particular, Inhibitors (Clopidogrel, Abciximab), Lipid management factors (Statins, Human Rubisco, Recombinant Rubisco, Rubisco and upregulated P53, resulting Ezetimibe, Fenofibrate, Niacin, nutritional change), Vitamin E and other Agonists or Rubisco Modulators, Polyacetylates, Hyperproliferation of Mitotic Antioxidants, Beta-Adrenoreceptor Agonists, Angiotensin Converting Phosphatidylethanolamine, Phosphatidylethanolamine capable cellular entities and Enzyme (ACE) Inhibitors (Ramipril, Captopril, Fosinopril), Angiotensin Methyltransferase, Methyltetrahydrofolate Reductase, Apoptosis through Parthanatos Receptor Blockers (ARBS) (Valsartan, Irbesartan, Olmesartan, Betaine Homocysteine Methyltransferase, Ancient Pink of Senescent/Completely Telmisartan), and Diabetic Therapeutics (Rosiglitazone, Pioglitazone). Himalayan Sea Salt instead of Table salt. Differentiated Cellular Entities. ACE Inhibitors such as ACEI lisinopril, inhibit MCP-1 in excreted fluids NAD+/Niacin may be essential. and improve renal function. Digital Object Identifier Diabetes Care, Volume 26, Number 8, August 2003. Pages 2421 to 2425. Factor Indicative Information Wholistic Factors to Accompany Therapeutics Information Protein Kinase C. Protein Kinase Hypericin and Psuedohypericin, known to Protein Kinase C Choline, Trimethylglycine, Folate/Methylfolate, C is known to be obtainable from St John’s Wort, activates SP-1, through Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, It was not possible phosphorylate Hypericum Japonicus, Hypericum TPA/PMA, cyclically Omega-3 Fatty Acids, Whole Food Organic Vitamins, to determine and Activate Perforatum and Echinacea, is known to since SP-1 also Complete Minerals, reliable consistent Choline Kinase inhibit Protein Kinase C. Hypericin activates TPA/PMA, but Flavonoid/Carotenoid/Phytochemical Supplement, information for the Beta in exhibits IC50 Value 1.7 SP-1 can activate Glandular Mix, KAL SOD3 or other Antioxidant Mix Protein Kinase C, associated Micrograms/Milliliter while Protein Kinase C with Catalase and Superoxide Dismutase, Choline Kinase and its versions a, Oncology. Psuedohypericin exhibits IC50 Value 15 through these same Inhibitors, Tyrosine Kinase Inhibitors, Inhibitors of AP- g, z, e, i, or µ. It Protein Kinase Micrograms/Milliliter. Both are specific mechanism. SP-1 1(x), including Citrus Fruit with Peelings/Rinds, is recommended C Diagnostic inhibitors of Protein Kinase C. PMID strongly activates Inhibitors of SP-1(X), Management of Homocysteine, that optimal levels Assay. 2558652. Isojacareubin from Hypericum Telomerase. SP-1 Management of S-Adenosyl Homocysteine or S- be determined for kit/ Japonicus, Hypericum Sarothranol, inhibits PEMT and Adenosyl Homocysteine inhibitors, inhibitors of the healthiest Hypericum Roeperanum, Garcina upregulates Choline Inducible Nitric Oxide Synthase, Inhibitors of Uncouple patients in incurred Nigrolineata, Garcinia Kinase. EGCG Nitric Oxide Synthase and its Reactive Molecular in practice and Xipshuanbannaensis can inhibit Protein Epigallocatechin and Species (L-Arginine, Tetrahydrobiopterin, NADPH, other patients Kinase C and inhibits Hepatocellular Quercetin inhibit Superoxide Dismutase, Catalase, Glutathione, considered in such Carcinoma. Protein Kinase C. Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, context as well as ISBN. 9781420006452 Complete B-Vitamins with B-12 Methylcobalamin, managed toward Uridine, Prebiotic/Probiotic to Manage Inflammation these optimal Factors Produced during Ingestion of some Choline levels. The Dense Foods, Enzymes which metabolize these factors or specification will synthesize these factors as well as precursors to these include these when factors, Water, Phosphatidyl-Monomethylethanolamine possible. (Phosphatidylmonomethylethanolamine or PMME), Human Rubisco, Recombinant Rubisco, Rubisco Agonists or Rubisco Modulators, Polyacetylates, Phosphatidylethanolamine, Phosphatidylethanolamine Methyltransferase, Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table salt. Factor Indicative Information Wholistic Factors to Accompany Therapeutics Information Protein Kinase C. www.link.sprin The Xanthone groups of Antioxidants are Protein Kinase C Choline, Trimethylglycine, Folate/Methylfolate, ger.com/protoco known to have specific selectivity with activates SP-1, through Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, It was not possible to l/10.1385/1- varying potency in inhibiting Protein Kinase TPA/PMA, cyclically Omega-3 Fatty Acids, Whole Food Organic Vitamins, determine reliable 59259-397- C and Hepatocellular Carcinoma. since SP-1 also activates Complete Minerals, Flavonoid/Carotenoid/Phytochemical consistent 6%3A63?no- Isocajareubin is a potent Antibacterial factor TPA/PMA, but SP-1 can Supplement, Glandular Mix, KAL SOD3 or other information for the access=true that is effect therapeutically for Microbes activate Protein Kinase Antioxidant Mix with Catalase and Superoxide Dismutase, Protein Kinase C, and Resistant to Methicillin. Isocajareubin is a C through these same Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, its versions a, g, z, e, Xanthone is also known to inhibit Matrix mechanism. SP-1 Inhibitors of AP-1(x), including Citrus Fruit with i, or µ. It is www.enzolifesc Metalloproteinases, C-Raf, MEK1/2, strongly activates Peelings/Rinds, Inhibitors of SP-1(X), Management of recommended that iences.com/ADI ERK1/2, MAPK, Fibroblast Growth Factor Telomerase. SP-1 Homocysteine, Management of S-Adenosyl Homocysteine optimal levels be -EKS- Receptor 1 FGFR-1, while increasing inhibits PEMT and or S-Adenosyl Homocysteine inhibitors, inhibitors of determined for the 420A/pkc- segmented C-PARP, P53, P21, E-Cadherin upregulates Choline Inducible Nitric Oxide Synthase, Inhibitors of Uncouple healthiest patients in kinase-activity- and Apoptosis. DOI 10.1038/srep12889. Kinase. EGCG Nitric Oxide Synthase and its Reactive Molecular Species incurred in practice kit/ Ruboxistaurin. Chelerythrine. Miyabenol C. Epigallocatechin and (L-Arginine, Tetrahydrobiopterin, NADPH, Superoxide and other patients Myricitrin. Gossypol. Verbascoside. BIM-1. Quercetin inhibit Protein Dismutase, Catalase, Glutathione, considered in such Kinase C. ISBN. Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, context as well as 9781420006452 Complete B-Vitamins with B-12 Methylcobalamin, managed toward these Uridine, Prebiotic/Probiotic to Manage Inflammation optimal levels. The Factors Produced during Ingestion of some Choline Dense specification will Foods, Enzymes which metabolize these factors or include these when synthesize these factors as well as precursors to these possible. factors, Water, Phosphatidyl-Monomethylethanolamine (Phosphatidylmonomethylethanolamine or PMME), Human Rubisco, Recombinant Rubisco, Rubisco Agonists or Rubisco Modulators, Polyacetylates, Phosphatidylethanolamine, Phosphatidylethanolamine Methyltransferase, Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table salt. Factor Indicative Information Wholistic Factors to Accompany Therapeutics Information Telomerase Shorter Telomeres is Vitamin B12 is correlated with www.hplusmagazine.co Choline, Trimethylglycine, Folate/Methylfolate, Biopsy. Copy correlated to up to increased Telomere length in m/2015/05/04/telomere Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, Number, %808 increased Females potentially resultant of -length-and-mortality- Omega-3 Fatty Acids, Whole Food Organic Vitamins, availability, potential for demise increased Estrogen which promotes danish-study-of-65000- Complete Minerals, molarity. in Breast Oncology Homocysteine depletion and more people/ Zinc Flavonoid/Carotenoid/Phytochemical Supplement, Conditions as well as PEMT specific Homocysteine such Carnosine provides the Glandular Mix, KAL SOD3 or other Antioxidant Mix Telomerase in up to %439 increased that B12 is accumulates as a Choline Kinase with Catalase and Superoxide Dismutase, Choline Kinase Serum. CPT potential for demise precursor to Methionine Synthase Inhibiting Imidazole Inhibitors, Tyrosine Kinase Inhibitors, Inhibitors of AP- Code of all causes among decreased ancillary Homocysteine Second Ring, 1(x), including Citrus Fruit with Peelings/Rinds, www.ncbi.nlm. those with the being transformed into Methionine. Scavenges Reactive Inhibitors of SP-1(X), Management of Homocysteine, nih.gov/pubme condition. %238 Astaxanthin, antioxidants, and Oxygen Species, Management of S-Adenosyl Homocysteine or S- d/15867214 increased potential Omega - 3 Fatty Acids are Protects DNA, Adenosyl Homocysteine inhibitors, inhibitors of for demise among associated with longer Telomeres. decreases Telomere Inducible Nitric Oxide Synthase, Inhibitors of Uncouple Telomere general population Vitamin K2. Probiotics. Krill Oil. Shortening and Nitric Oxide Synthase and its Reactive Molecular Length full might be useful Magnesium. Polyphenols. Increases the En Vitro Species (L-Arginine, Tetrahydrobiopterin, NADPH, Panel CPT statistical Polyphenols, Vitamin A, Circumin, highest number of Superoxide Dismutase, Catalase, Glutathione, Code 88184, consideration in this Exercise and intermittent Fasting. cellular divisions Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, 88185 regard. www.articles.mercola.com/sites/arti known as the Hayflick Complete B-Vitamins with B-12 Methylcobalamin, www.californiahealth cles/archive/2012/05/09/the- Limit. Uridine, Prebiotic/Probiotic to Manage Inflammation span.com/wp- nutrients-most-likely-to-let-you- Factors Produced during Ingestion of some Choline content/uploads/lectu live-to-be-much-older-than- Dense Foods, Enzymes which metabolize these factors or res/Telomeres-and- 100.aspx synthesize these factors as well as precursors to these Telomerase- factors, Water, Phosphatidyl-Monomethylethanolamine Activation- (Phosphatidylmonomethylethanolamine or PMME), Hollywood-2016.pdf Human Rubisco, Recombinant Rubisco, Rubisco Agonists or Rubisco Modulators, Polyacetylates, Phosphatidylethanolamine, Phosphatidylethanolamine Methyltransferase, Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table salt. Factor Indicative Information Wholistic Factors to Accompany Therapeutics Information Telomerase Telomerase as a When inhibiting AP-1 using TAM67, WNT- Telomerase is Choline, Trimethylglycine, Folate/Methylfolate, Biopsy. Copy diagnostic. 1and ErbB2 enabled Neoplasms of the Breast inhibited by AP-1 Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, Number, www.cambia.org/dais both were inhibited and prevented, although and upregulated Omega-3 Fatty Acids, Whole Food Organic Vitamins, availability, y/Telomerase/2389/g3 C-Myc enabled Neoplasms were not. It may by SP-1. Complete Minerals, molarity. /2930.html be necessary to inhibit Telomerase or enable Flavonoid/Carotenoid/Phytochemical Supplement, www.emdmillipore.co Telomerase separately from AP-1 Inhibition, Telomerase are Glandular Mix, KAL SOD3 or other Antioxidant Mix Telomerase in m/US/en/product/TR since inhibiting AP-1, in a study, did not indicative of with Catalase and Superoxide Dismutase, Choline Serum. APeze-XL- prevent C-Myc induced Neoplasm and C- pathology. DOI Kinase Inhibitors, Tyrosine Kinase Inhibitors, www.ncbi.nlm. Telomerase- Myc stimulates Telomerase. ISSN 1055-9965, 10.1007/s10147- Inhibitors of AP-1(x), including Citrus Fruit with nih.gov/pubme Detection- Volume 16, Issue 12, Supplement, Pages 011-0230-6 Peelings/Rinds, Inhibitors of SP-1(X), Management of d/15867214 Kit,MM_NF-S7707 A145/ Homocysteine, Management of S-Adenosyl Telomere Length is considered to be Other data Homocysteine or S-Adenosyl Homocysteine inhibitors, Telomere participative or indicative of particular health suggests that inhibitors of Inducible Nitric Oxide Synthase, Length full conditions, including detrimental aspects of %338 increase in Inhibitors of Uncouple Nitric Oxide Synthase and its Panel CPT Aging. potential demise Reactive Molecular Species (L-Arginine, Code 88184, www.ncbi.nlm.nih.gov/pmc/articles/PMC331 that is reduced Tetrahydrobiopterin, NADPH, Superoxide Dismutase, 88185 8193/ %154 and %140 Catalase, Glutathione, Citrulline/Arginine/Ornithine), Folate is associated with Telomere Length in when removing NAD+, Hyaluronic Acid, Complete B-Vitamins with Males. Propolis is suggested to inhibit outliers and B-12 Methylcobalamin, Uridine, Prebiotic/Probiotic to Telomerase Activity. introducing Manage Inflammation Factors Produced during www.livestrong.com/article/506649-foods- cohorts among Ingestion of some Choline Dense Foods, Enzymes that-boost-telomeres-telomerase demographic which metabolize these factors or synthesize these characteristics factors as well as precursors to these factors, Water, Phosphatidyl-Monomethylethanolamine (Phosphatidylmonomethylethanolamine or PMME), Human Rubisco, Recombinant Rubisco, Rubisco Agonists or Rubisco Modulators, Polyacetylates, Phosphatidylethanolamine, Phosphatidylethanolamine Methyltransferase, Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table salt. Factor Indicative Information Wholistic Factors to Accompany Therapeutics Information Tyrosine Tyrosine Kinase Inhibitor Tyrosine Kinase Inhibitor Patients are correlated to Choline, Trimethylglycine, Folate/Methylfolate, Kinase Therapy, particularly increased Potential for Cardiac Impairment and other Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, Inhibitors Imatinib Therapy , has disease in study, although the study could not Omega-3 Fatty Acids, Whole Food Organic Vitamins, Tyrosine. been shown to achieve a indicate if the risk was associated with health status Complete Minerals, Non 2% 10 Yr/annum level of before therapy, if therapy reduced Kinase levels or if Flavonoid/Carotenoid/Phytochemical Supplement, Receptor demise from all the cause of conditions requiring Tyrosine Kinase Glandular Mix, KAL SOD3 or other Antioxidant Mix Tyrosine causalities among CML Inhibitors were remediate or if the factors which with Catalase and Superoxide Dismutase, Choline Kinase patients which is an Tyrosine Kinase Inhibitors activated were not Kinase Inhibitors, Tyrosine Kinase Inhibitors, Inhibitors Diagnostic improvement from a Five activated by other factors. DOI 10.1038/bjc.2017.88 of AP-1(x), including Citrus Fruit with Peelings/Rinds, Assay. YR/ annum population Tyrosine Kinase can act upon Choline Kinases. Inhibitors of SP-1(X), Management of Homocysteine, depletion rate. The Tyrosine Kinases, thus, have potential benefit in Management of S-Adenosyl Homocysteine or S- improvement is not pervasive pathology. Adenosyl Homocysteine inhibitors, inhibitors of www.blue.re calculable, and would be Inducible Nitric Oxide Synthase, Inhibitors of Uncouple gence.com/tr about % 99,000 percent Nitric Oxide Synthase and its Reactive Molecular gmedpol/gen or more of calculated. Species (L-Arginine, Tetrahydrobiopterin, NADPH, eticTesting/gt DOI 10.1002/cncr.26679 Superoxide Dismutase, Catalase, Glutathione, 20.pdf Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, Tyrosine Kinase 18.10 Complete B-Vitamins with B-12 Methylcobalamin, was threshold for CML Uridine, Prebiotic/Probiotic to Manage Inflammation with median of 801.93 Factors Produced during Ingestion of some Choline Micromoles Per Liter Dense Foods, Enzymes which metabolize these factors while lower levels for or synthesize these factors as well as precursors to these Healthy Patients was a factors, Water, Phosphatidyl-Monomethylethanolamine low as 0.063. PMID (Phosphatidylmonomethylethanolamine or PMME), 21694468 Human Rubisco, Recombinant Rubisco, Rubisco Agonists or Rubisco Modulators, Polyacetylates, Phosphatidylethanolamine, Phosphatidylethanolamine Methyltransferase, Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table salt. Factor Indicative Information Information Wholistic Factors to Accompany Therapeutics

Tyrosine Tyrosine Kinase Inhibitor Herbimycin-A, genistein, and erbstatin each inhibit Choline, Trimethylglycine, Folate/Methylfolate, Kinase Therapy, particularly choline kinase. J Immunol, Volume 150, Number 2, Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, Inhibitors Imatinib Therapy , has Pages 605 to 616, January,15, 1993. ST1571, SU5416, Omega-3 Fatty Acids, Whole Food Organic Vitamins, Tyrosine. been shown to achieve a P22408, and PD 0165557 are inhibitors of Tyrosine Complete Minerals, Flavonoid/Carotenoid/Phytochemical Non Receptor 2% 10 Yr/annum level of Kinase. Flavones and Isoflavones including Quercetin Supplement, Glandular Mix, KAL SOD3 or other Tyrosine demise from all and Genistein. Indolecarbazone, Staurosporine and Antioxidant Mix with Catalase and Superoxide Dismutase, Kinase causalities among CML Lavendustin. Clavilactones CA, CB and CD. K252a Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, Diagnostic patients which is an from Nocardiopsis. CEP-701, CEP-751, UCN Inhibitors of AP-1(x), including Citrus Fruit with Assay. improvement from a Five -01. Quercetin inhibits tyrosine kinases, protein Peelings/Rinds, Inhibitors of SP-1(X), Management of YR/ annum population kinase C, and phosphatidyl inositol-3 kinase. Homocysteine, Management of S-Adenosyl Homocysteine depletion rate. The Quinazolines, pyridopyrimidines and other or S-Adenosyl Homocysteine inhibitors, inhibitors of www.blue.reg improvement is not heterocyles. Phenylamino-pyrimidines. Benzylidene Inducible Nitric Oxide Synthase, Inhibitors of Uncouple ence.com/trg calculable, and would be malononitrile, tyrphostins and its analogues. Oncogene Nitric Oxide Synthase and its Reactive Molecular Species medpol/geneti about % 99,000 percent or Vo,ume 19. Pages 5690 to 5701. Circumin. (L-Arginine, Tetrahydrobiopterin, NADPH, Superoxide cTesting/gt20. more of calculated. DOI Trypterygium Wiilfordi. Green Tea Catechins. PMID Dismutase, Catalase, Glutathione, pdf 10.1002/cncr.26679 12677178 . Brevilin A from Litsea Glutinosa. Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, Catechins from green tea leafs, Genestin, Apeginin in Complete B-Vitamins with B-12 Methylcobalamin, Tyrosine Kinase 18.10 was Chamomile. Curcumin from in turmeric, Diadzein, Uridine, Prebiotic/Probiotic to Manage Inflammation threshold for CML with Epigallocatechin galate from Green Tea, Hypericin Factors Produced during Ingestion of some Choline Dense median of 801.93 which is St Johns Wort, Artemisia annua (Chinese Foods, Enzymes which metabolize these factors or Micromoles Per Liter wormwood), Viscum album (European mistletoe), synthesize these factors as well as precursors to these while lower levels for Scutellaria baicalensis (Chinese skullcap), resveratrol, factors, Water, Phosphatidyl-Monomethylethanolamine Healthy Patients was a proanthocyanidin (grape seed extract, red wine), (Phosphatidylmonomethylethanolamine or PMME), low as 0.063. PMID Magnolia officinalis (Chinese magnolia tree), Camellia Human Rubisco, Recombinant Rubisco, Rubisco Agonists 21694468 sinensis (green tea), Ginkgo biloba, Poria cocos (Fu or Rubisco Modulators, Polyacetylates, Ling), Zingiber officinalis Ginger, Panax ginseng, Phosphatidylethanolamine, Phosphatidylethanolamine Rabdosia rubescens hora (Rabdosia). The Methyltransferase, Methyltetrahydrofolate Reductase, Carahealth.com website. Imatanib. Dasatanib. Betaine Homocysteine Methyltransferase, Ancient Pink Lapatanib. Vandetanib is a RET-Tyrosine Kinase Himalayan Sea Salt instead of Table salt. Inhibitor. Pazopanib. Factor Indicative Information Wholistic Factors to Accompany Therapeutics Information General Protein Kinase Afatinib is indicated for ErbB Group. flibercept is indicated Choline, Trimethylglycine, Folate/Methylfolate, Glutathione, Protein Panel for VEGF. Axitinib is indicated for VEGFR, PDGFR, c-KIT. Probiotic/Prebiotic, Complete-B Vitamins, Omega-3 Fatty Acids, Kinase Bevacizumab is indicated for VEGF. Bosutinib is indicated for Whole Food Organic Vitamins, Complete Minerals, Activity. www.carnabio.com Bcr-Abl. Cabozantinib is indicated for c-Met, VEGFR2. Flavonoid/Carotenoid/Phytochemical Supplement, Glandular Mix, /images/news0409 Crizotinib is indicated for ALK, HGFR, c-MET. Dasatinib is KAL SOD3 or other Antioxidant Mix with Catalase and Superoxide 11.pdf indicated for Bcr-Abl, Src, c-KIT. Erlotinib is indicated for Dismutase, Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, EGFR. Gefitinib is indicated for EGFR. Imatinib is indicte for Inhibitors of AP-1(x), including Citrus Fruit with Peelings/Rinds, Bcr-Abl. Lapatinib is indicated for HER2. Nilotinib is indicted Inhibitors of SP-1(X), Management of Homocysteine, Management of for Bcr-Abl. Panitumumab is indicated for EGFR. Pazopanib S-Adenosyl Homocysteine or S-Adenosyl Homocysteine inhibitors, is indicated for VEGFR, PDGFR, and c-KIT. Pegaptanib is inhibitors of Inducible Nitric Oxide Synthase, Inhibitors of Uncouple indicated for VEGF. Ponatinib is indicated for Bcr-Abl, Nitric Oxide Synthase and its Reactive Molecular Species (L-Arginine, BEGFR, PDGFR, FGFR, EPH, SRC, c-KIT, RET, TIE2, Tetrahydrobiopterin, NADPH, Superoxide Dismutase, Catalase, FLT3, T315I. Ranibizumab is indicated for VEGF-A. Glutathione, Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, Regorafenib is indicated for RET, VEGFR, and PDGFR. Complete B-Vitamins with B-12 Methylcobalamin, Uridine, Ruxolitinib is indicated for JAK. Sorafenib is indicted form Prebiotic/Probiotic to Manage Inflammation Factors Produced during VEGFR, PDGFR, BRAF, c-KIT, others. Sunitinib is indicated Ingestion of some Choline Dense Foods, Enzymes which metabolize for VEGFR, PDGFR. Tofacitinib is indicated for Pfizer JAK. these factors or synthesize these factors as well as precursors to these Trastuzumab is indicated for HER2. Vandetanib is indicated factors, Water, Phosphatidyl-Monomethylethanolamine for VEGFR, EGFR, RET, and BRK. Vemurafenib is indicated (Phosphatidylmonomethylethanolamine or PMME), Human Rubisco, for BRAF. WIKIPEDIA, Protein Kinases. Vasular Recombinant Rubisco, Rubisco Agonists or Rubisco Modulators, Endothelial Growth Factor A or VEFG-A is inhibited by Polyacetylates, Phosphatidylethanolamine, Phosphatidylethanolamine Bevacizumab or Avastin. EGFR is inhibited by Cetuximab. Methyltransferase, Methyltetrahydrofolate Reductase, Betaine HER2/Neu Receptor is inhibited by the Trastuzumab Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt Herceptin. EGFR is inhibited by Gefitinib. Lapatanib inhibits instead of Table salt. EFGR and HER2/Neu. Panitumumab inhibits EGFR and is also known as Vectibix. Vandetenib inhibits VEGFR, EGFR, and RET-Tyrosine Kinase. Factor Indicative Information Information Wholistic Factors to Accompany Therapeutics

General Protein Kinase Panel Erlotinib treats Pancreatic, Non-Small Cellular Pulmonary, and other Choline, Trimethylglycine, Folate/Methylfolate, Protein Oncology. Nilotinib treats Chronic Myelogenous Leukemia. Pazopanib treats Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, Kinase www.carnabio.com/images Renal Cellular Carcinoma and Soft Tissue Carcinoma. Sorafenib treat Omega-3 Fatty Acids, Whole Food Organic Vitamins, Activity /news040911.pdf Advanced Renal Cellular Carcinoma and Hepatocellular Carcinoma. Complete Minerals, Flavonoid/Carotenoid/Phytochemical . Pegaptinib and Ranibizumab treat Web Age Associated Macular Supplement, Glandular Mix, KAL SOD3 or other Degeneration of Neovascular type. www.news-medical.net/life- Antioxidant Mix with Catalase and Superoxide Dismutase, sciences/Drugs-Targeting-Kinase-Inhibitors.aspx. Honokiol inhibits a Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, diverse array of inflammatory pathways and differentiation factors. doi: 1 0 Inhibitors of AP-1(x), including Citrus Fruit with .1 1 11 /j.1 7 45 -7 2 5 4 .20 0 8 .0 0 72 5 .x Cyclin Dependent Kinase are Peelings/Rinds, Inhibitors of SP-1(X), Management of Kinases which Competitively Phosphorylate Cyclins, compared to Homocysteine, Management of S-Adenosyl Homocysteine Dephosphorylation by Phosphatases. Cyclins typically stimulate the or S-Adenosyl Homocysteine inhibitors, inhibitors of progression of the Cellular Cycle into a subsequent phase, correlative to the Inducible Nitric Oxide Synthase, Inhibitors of Uncouple Phase associated with the Cyclin, when Cyclins are more prevalently Nitric Oxide Synthase and its Reactive Molecular Species phosphorylated than dephosphorylated or when a threshold of (L-Arginine, Tetrahydrobiopterin, NADPH, Superoxide phosphorylation occurs along with changes in the environment. Inhibition Dismutase, Catalase, Glutathione, of Cyclins can be useful and effective in Oncology. Palbociclib inhibits Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, CDK4 and CDK 6 with IC50 of 11 nM/16 nM. Dinaciclib inhibits CDk2, Complete B-Vitamins with B-12 Methylcobalamin, Uridine, CDK5, CKD2, and CKD9 1 nM IC50 to 4 nM IC50 or molar level required Prebiotic/Probiotic to Manage Inflammation Factors to exhibit 50% Response in culture tissue. Flavopiridol inhibits CDK1, Produced during Ingestion of some Choline Dense Foods, CKD2, CDK4, CDK6 with an IC50 about 40 nM. Senexin A inhibits CDK8 Enzymes which metabolize these factors or synthesize these and CDK19. Wogonin inhibits N-Acetyltransferase, and CDK9. Lists of factors as well as precursors to these factors, Water, CDK Inhibitors can be found on the internet. Phosphatidyl-Monomethylethanolamine (Phosphatidylmonomethylethanolamine or PMME), Human Rubisco, Recombinant Rubisco, Rubisco Agonists or Rubisco Modulators, Polyacetylates, Phosphatidylethanolamine, Phosphatidylethanolamine Methyltransferase, Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table salt. Factor Indicative Information Information Wholistic Factors to Accompany Therapeutics 12-O- AP-1 and Protein Kinase Inhibitors of TPA/PMA Relevant Therapeutics Choline, Trimethylglycine, Folate/Methylfolate, Tetradecano C can occur in a cycle include alpha-difluoromethyl Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, ylphorbol- with PMA/TPA and ornithine (DFMO), TPA/PMA is considered to Omega-3 Fatty Acids, Whole Food Organic Vitamins, 13-acetate seems to be participative 1,25(OH)2D3 or its be an Oncology Inhibitor in Complete Minerals, Flavonoid/Carotenoid/Phytochemical known as in numerous Microbial, analogues, and retinoic acid. Hepatic Oncology, although Supplement, Glandular Mix, KAL SOD3 or other TPA or Oncology and other PMID 3011686. Tumeric and this inhibition requires YAP Antioxidant Mix with Catalase and Superoxide known as Pathology, although its Passion flower are among the Protein and AMOT Protein. Dismutase, Choline Kinase Inhibitors, Tyrosine Kinase PMA. role seems to be as a numerous factors known to DOI 10.1038/srep44940 Inhibitors, Inhibitors of AP-1(x), including Citrus Fruit Oncology transcription factor or inhibit TPA/PMA. DOI Peucedanum japonicum with Peelings/Rinds, Inhibitors of SP-1(X), Management Gene enhancer of other 10.1006/phrs.2001.0936. Thunb. (PJT) inhibits of Homocysteine, Management of S-Adenosyl Expression. transcription factors. Auraptene and Umbelliferone TPA/PMA enabled Homocysteine or S-Adenosyl Homocysteine inhibitors, TPA/PMA Diagnostic from Grapefruit and Citrus Metastatic and Pathogenic inhibitors of Inducible Nitric Oxide Synthase, Inhibitors assay Fruits DOI: 10.1111/j.1349- Oncology. DOI of Uncouple Nitric Oxide Synthase and its Reactive www.abcam.com/phorbo 7006.1997.tb00402.x. 10.3892/ijmm.2015.2417 Molecular Species (L-Arginine, Tetrahydrobiopterin, l-12-myristate-13- Inhibitors or AP-1 may be GF 109203X inhibits NADPH, Superoxide Dismutase, Catalase, Glutathione, acetate-pma- effective in inhibiting TPA/PMA PMID 8280132. Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, ab120297.html TPA/PMA. DHA and EPA Resevertrol inhibits Complete B-Vitamins with B-12 Methylcobalamin, from Omega 3, but not TPA/PMA DOI Uridine, Prebiotic/Probiotic to Manage Inflammation Arachidonic Acid inhibit 10.1074/jbc.273.34.21875 Factors Produced during Ingestion of some Choline Epidermal Growth Factor, Flavopiridol disrupts Dense Foods, Enzymes which metabolize these factors or AP-1, and TPA/PMA, TPA/PMA enabled synthesize these factors as well as precursors to these although Arachidonic Acid differentiation and its CDKI factors, Water, Phosphatidyl-Monomethylethanolamine abrogates DHA/EPA activity in CML cellular (Phosphatidylmonomethylethanolamine or PMME), inhibition of these factors. entities while resulting in Human Rubisco, Recombinant Rubisco, Rubisco PMCID PMC34699. Hops or Apoptosis Outcomes. Agonists or Rubisco Modulators, Polyacetylates, Humulus Lupulus, Capsaicin www.cancerres.aacrjournals. Phosphatidylethanolamine, Phosphatidylethanolamine and Catechins. org/content/61/6/2583 Methyltransferase, Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table salt. Factor Indicative Information Information Wholistic Factors to Accompany Therapeutics Protein Protein Kinase A Inhibitors of Protein Kinase A Extended Protein Kinase A Choline, Trimethylglycine, Folate/Methylfolate, Glutathione, Kinase A or participates in Choline include 1-(5-isoquinolinyl- signaling has been suggested Probiotic/Prebiotic, Complete-B Vitamins, Omega-3 Fatty cAMP- Kinase Beta and Catalysis sulfonyl)-2-methylpiperazine to be a substantial causal Acids, Whole Food Organic Vitamins, Complete Minerals, Dependent exhibited by 12-O- (H-7), N-[2- factor in Cardiac Impairment Flavonoid/Carotenoid/Phytochemical Supplement, Kinase Tetradecanoylphorbol-13- (methylamino)ethyl]-5- and Sudden Adverse Health Glandular Mix, KAL SOD3 or other Antioxidant Mix with Oncology acetate known as TPA or isoquinoline-sulfonamide (H-8) events. DOI Catalase and Superoxide Dismutase, Choline Kinase Gene known as PMA. Protein and 1,(5- 10.1161/hh2301.100003. Inhibitors, Tyrosine Kinase Inhibitors, Inhibitors of AP-1(x), Expression. Kinase A is inhibited by isoquinolynylsulfonyl)-2,3- Scutelleria Baicalensis inhibits including Citrus Fruit with Peelings/Rinds, Inhibitors of SP- Okadaic Acid although dimethylpiperazine (H-5) . Protein Kinase although it 1(X), Management of Homocysteine, Management of S- Okadaic Acid upregulates PMID 3011686. Protein inhibits P-Glycoprotein Also. Adenosyl Homocysteine or S-Adenosyl Homocysteine CREB, Elk1 and cFos, Kinase C Diagnostic Assay Kaempferol inhibits Choline inhibitors, inhibitors of Inducible Nitric Oxide Synthase, potentiating upregulation www.cellbiolabs.com/sites/defa Kinase. DOI Inhibitors of Uncouple Nitric Oxide Synthase and its of AP1. AP1 increases ult/files/STA-414-96-well- 10.1021/acs.jafc.5b05456. Reactive Molecular Species (L-Arginine, correlate to Pathology checkpoint-kinase-activity- The Protein Kinase De Tetrahydrobiopterin, NADPH, Superoxide Dismutase, when PEMT is decreased assay-kit.pdf website exhibits numerous Catalase, Glutathione, Citrulline/Arginine/Ornithine), and choline Kinase is www.cellbiolabs.com/sites/defa Protein Kinase A Inhibitors NAD+, Hyaluronic Acid, Complete B-Vitamins with B-12 upregulated. DOI ult/files/STA-414-96-well- www.proteinkinase.biz/75- Methylcobalamin, Uridine, Prebiotic/Probiotic to Manage 10.1111/j.1471- checkpoint-kinase-activity- pka-inhibitors. Inflammation Factors Produced during Ingestion of some 4159.2003.02334.x. assay-kit.pdf. Apigenin and Choline Dense Foods, Enzymes which metabolize these Inflammation is generally Resveratrol inhibit Protein factors or synthesize these factors as well as precursors to associated with a %50 Kinase A. these factors, Water, Phosphatidyl-Monomethylethanolamine increase in potential for DOI: 10.1039/C4FO00626G. (Phosphatidylmonomethylethanolamine or PMME), Human demise. Ellagitannins inhibit AMPK. Rubisco, Recombinant Rubisco, Rubisco Agonists or DHA and EPA seem to have no Rubisco Modulators, Polyacetylates, deleterious effects. PMID Phosphatidylethanolamine, Phosphatidylethanolamine 11152679. Methyltransferase, Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table salt. Factor Indicative Information Information Wholistic Factors to Accompany Therapeutics

Cyclooxygenase Cyclooxygenase and Cyclooxygenase is Lipoxygenase is inhibited by Choline, Trimethylglycine, Folate/Methylfolate, and Lipoxygenase required to inhibited by Apigenin tea, Allicin garlic, Berbamine hu- Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, Lipoxygenase. produce Arachidonic Acid, Baicalein from Scute, Chang, Berberine Coptis from Omega-3 Fatty Acids, Whole Food Organic Vitamins, most Inflammation, Berberine from Phellodendron, Boswellic Acid Complete Minerals, Flavonoid/Carotenoid/Phytochemical www.neogenom Leukotrienes, philodendron, Curcumin from frankincense, Caffeic acid Supplement, Glandular Mix, KAL SOD3 or other ics.com/portals/ Thromboxanes, from Turmeric, Oleanolic from Taraxacum, dandelion Antioxidant Mix with Catalase and Superoxide 0/PDF/NeoGeno Prostaglandins and some acid from rosemary, Epicatechin tea, Epicatechin- Dismutase, Choline Kinase Inhibitors, Tyrosine Kinase micsTestCatalog Reactive Oxygen Species. Eicosapentaenoic Acid gallate tea, Epigallocatechin tea, Inhibitors, Inhibitors of AP-1(x), including Citrus Fruit .pdf Arachidonic Acid is from Garlic, Evodiamine or Fisetin Chih-shih, Flavones, with Peelings/Rinds, Inhibitors of SP-1(X), Management inhibited by Aucubin from Evodol Evodia, Quercetin, Galangin Galanga, Morin Morus, of Homocysteine, Management of S-Adenosyl www.genedx.co Chaste Tree Berry, Resveratrol, Rutaec arpine Quercetin, Theaflavin from Homocysteine or S-Adenosyl Homocysteine inhibitors, m/test- Oestrogen, as well as from Evodia, Ursolic Acid Digallate tea, Ursolic acid from inhibitors of Inducible Nitric Oxide Synthase, Inhibitors catalog/disorder Neutralized by from Ligustrum and Ligustrum. Aucubin from Chaste of Uncouple Nitric Oxide Synthase and its Reactive s/ichthyosis- Eicosapentaenoic Acid, Rosemary. Lipoxygenase Tree Berry. Cyclooxygenase 2 Molecular Species (L-Arginine, Tetrahydrobiopterin, congenital- Docosahexaenoic acid and Elisa Kits. Elisa Kit NADPH, Superoxide Dismutase, Catalase, Glutathione, recessive/31957/ the Omega-6 DGLA but www.biocompare.com/pfu/ www.mybiosource.com/prods/ELI Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, the DGLA also potentiates 110627/soids/2- SA-Kit/Human/cyclooxygenase-2- Complete B-Vitamins with B-12 Methylcobalamin, Arachidonic Acid. 4894/ELISA_Kit/ELISA_L COX-2/COX- Uridine, Prebiotic/Probiotic to Manage Inflammation Inflammation is generally OX 2/datasheet.php?products_id=2643 Factors Produced during Ingestion of some Choline Dense associated with a %50 04. Cyclooxgenase 2 Elisa Kit. Foods, Enzymes which metabolize these factors or increase in potential www.lsbio.com/products/elisakits? synthesize these factors as well as precursors to these demise. q=COX- factors, Water, Phosphatidyl-Monomethylethanolamine 1&adid=7601&gclid=CIunwK7b5 (Phosphatidylmonomethylethanolamine or PMME), 9UCFQJsfgodEokPxA Human Rubisco, Recombinant Rubisco, Rubisco Agonists or Rubisco Modulators, Polyacetylates, Phosphatidylethanolamine, Phosphatidylethanolamine Methyltransferase, Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table salt. Factor Indicative Information Information Wholistic Factors to Accompany Therapeutics

Genetic Test for P53, Screen for Genetic Anomaly CRISPR Gene Editing and Whole Genome Assay. Choline, Trimethylglycine, Folate/Methylfolate, PTEN, MDM2, generally and from biopsy Genetic Repair. www.support.illumina Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, PUMA, C-Myc, after the other indicators Mitochondrial DNA Gene .com/array/array_kits/ Omega-3 Fatty Acids, Whole Food Organic Vitamins, PEMT1, PEMT2, have been remediate because Editing. whole- Complete Minerals, Flavonoid/Carotenoid/Phytochemical BRCA1 and whole atypical phenotype is genome_dasl_ht_assa Supplement, Glandular Mix, KAL SOD3 or other Genome Screening typically from epigenetic www.hindawi.com/journals/b y_kit.html Antioxidant Mix with Catalase and Superoxide Dismutase, CPT Codes Whole factors including Amehsi mri/2015/305716/ Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, Genome Sequencing Indicators and less typically Crispr Genome Inhibitors of AP-1(x), including Citrus Fruit with resultant of Bona Fide Editing and Repair. Peelings/Rinds, Inhibitors of SP-1(X), Management of Genetic Structural Anomaly. There is the potential to use www.horizondiscover Homocysteine, Management of S-Adenosyl Homocysteine Primers which obscure y.com/gene- or S-Adenosyl Homocysteine inhibitors, inhibitors of aspects of impaired DNA, editing/crispr Inducible Nitric Oxide Synthase, Inhibitors of Uncouple including whole regions of www.fas.org/sgp/crs/ Nitric Oxide Synthase and its Reactive Molecular Species DNA and RNA Chromosomes to prevent misc/R44824.pdf (L-Arginine, Tetrahydrobiopterin, NADPH, Superoxide supplementation can assist in Okazaki Fragments from Dismutase, Catalase, Glutathione, alleviating Genetic being synthesized, resulting Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, Conditions including in different modalities of Complete B-Vitamins with B-12 Methylcobalamin, Oncology or other DNA repair, as well as Uridine, Prebiotic/Probiotic to Manage Inflammation conditions. RNA can be inhibiting DNA repair such Factors Produced during Ingestion of some Choline Dense provided which is translated that following repair Foods, Enzymes which metabolize these factors or into Proteins which are mechanisms consider omitted synthesize these factors as well as precursors to these required for biophysiological synthesized extents of DNA factors, Water, Phosphatidyl-Monomethylethanolamine function. Similarly, proteins repair as Double or Single (Phosphatidylmonomethylethanolamine or PMME), which are functional and Strand Segmentation. Human Rubisco, Recombinant Rubisco, Rubisco Agonists optimal, designer proteins, Homologies from other or Rubisco Modulators, Polyacetylates, can be utilized to enable Strands of DNA can then be Phosphatidylethanolamine, Phosphatidylethanolamine optimal biophysiological copied into the impaired Methyltransferase, Methyltetrahydrofolate Reductase, faction, including enzymes. aspects of DNA, Chromatin Betaine Homocysteine Methyltransferase, Ancient Pink or Chromosomes. Himalayan Sea Salt instead of Table salt. Factor Indicative Information Information Wholistic Factors to Accompany Therapeutics

Free Phosphorylated Free Phosphocholine aggregates upon Acetyl-CoA should alleviate a required Choline, Trimethylglycine, Folate/Methylfolate, Choline or Necrotic and Apoptotic Cellular Entities and circumstance for Oncology and a require Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, Phosphocholine. causes the Innate Immune System to become Acetylation with N-Acetyl L-Cysteine Omega-3 Fatty Acids, Whole Food Organic Vitamins, activated suggest that impaired Necrosis or already utilized provides Acetyl groups Complete Minerals, Flavonoid/Carotenoid/Phytochemical Oncology Gene Apoptosis produces a persistent systemic and Cysteine which both benefit Acetyl- Supplement, Glandular Mix, KAL SOD3 or other Expression. inflammation through the Complements CoA levels Antioxidant Mix with Catalase and Superoxide Dismutase, Innate Immunological System Pathway.’ Choline upregulation of PEMT relieves Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, A study exhibited P53 inhibition of Acetyl-CoA synthesis. Inhibitors of AP-1(x), including Citrus Fruit with Phosphocholine 1.28 C-Reactive Protein Diagnostic using Already Utilized. Peelings/Rinds, Inhibitors of SP-1(X), Management of and www.researchgate.net/publication/26835322_ AP-1 Inhibition by numerous factors Homocysteine, Management of S-Adenosyl Homocysteine Glycerophosphochol A_new_high- enables Acetyl-CoA Synthesis. or S-Adenosyl Homocysteine inhibitors, inhibitors of ine at 3.64 Sensitive_nephelometric_method_for_assayin Pantothenic Acid is an early factor in Inducible Nitric Oxide Synthase, Inhibitors of Uncouple Micromoles per liter g_serum_C- Acetyl-CoA Synthesis. Choline Kinase Nitric Oxide Synthase and its Reactive Molecular Species in healthy Patients Reactive_protein_based_on_phosphocholine_ Inhibitors inhibit accumulation of (L-Arginine, Tetrahydrobiopterin, NADPH, Superoxide while interaction DOI Phosphocholine. Dismutase, Catalase, Glutathione, Phosphocholine was 10.1515/CCLM.2009.312 Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, 52 percent higher www.mybiosource.com/prods/ELISA- Complete B-Vitamins with B-12 Methylcobalamin, Uridine, and Kit/Human/Phosphoethanolamine- Prebiotic/Probiotic to Manage Inflammation Factors Glycerophosphochol phosphocholine- Produced during Ingestion of some Choline Dense Foods, ine was 76 percent phosphatase/PHOSPHO1/datasheet.php?prod Enzymes which metabolize these factors or synthesize these higher in ucts_id=280274. factors as well as precursors to these factors, Water, Alzheimer’s. Phosphatidyl-Monomethylethanolamine Oncology and other (Phosphatidylmonomethylethanolamine or PMME), Human pathologies exhibit Rubisco, Recombinant Rubisco, Rubisco Agonists or similar differences. Rubisco Modulators, Polyacetylates, Phosphatidylethanolamine, Phosphatidylethanolamine Methyltransferase, Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table salt. Factor Indicative Information Information Wholistic Factors to Accompany Therapeutics Free Amazingly, the clinical literature observes Hydroxy Citric Acid inhibits Citrate Choline, Trimethylglycine, Folate/Methylfolate, Phosphorylated that Phosphatidylcholine to Lyase, potentiates inhibited ATP-citrate Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, Choline or Glycerophosphocholine Ratio, as lyase which causes which, outside of the Omega-3 Fatty Acids, Whole Food Organic Vitamins, Phosphocholine. Phosphatidylcholine molarity divided by Mitochondria, potentates segmentation of Complete Minerals, Flavonoid/Carotenoid/Phytochemical Glycerophosphocholine Molarity, is Citrate, to Oxaloacetate and Oxaloacetate Supplement, Glandular Mix, KAL SOD3 or other Oncology Gene exhibited in models of highly Pathogenic to Acetyl-CoA. However, when Statins Antioxidant Mix with Catalase and Superoxide Expression. Glial Neoplasm pervasively, suggesting that or HMG-CoA Reducatase Inhibitors are Dismutase, Choline Kinase Inhibitors, Tyrosine Kinase how far below 1 this ratio may be can be being utilized, this cycle can cause Inhibitors, Inhibitors of AP-1(x), including Citrus Fruit A study exhibited correlated to level of Pathogenic activity as impaired muscle tissue to deteriorate with Peelings/Rinds, Inhibitors of SP-1(X), Management Phosphocholine well as level of progression. Specifically, rapidly, and should be utilized only when of Homocysteine, Management of S-Adenosyl 1.28 and the study observed that Ki – 67, which is an no such impairment is known. Cardiolipin Homocysteine or S-Adenosyl Homocysteine inhibitors, Glycerophosphocho indicator of Mitotic Activity used in is a good test to determine active muscle inhibitors of Inducible Nitric Oxide Synthase, Inhibitors line at 3.64 Oncology to indicate level of division tissue impairment. of Uncouple Nitric Oxide Synthase and its Reactive Micromoles per exhibited by Neoplasm, is correlated to how Molecular Species (L-Arginine, Tetrahydrobiopterin, liter in healthy far below 1 this Ratio may be. Simply, the NADPH, Superoxide Dismutase, Catalase, Glutathione, Patients while level Phosphocholine metabolites is Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, Phosphocholine was correlated to KI – 67 in models of Oncology, Complete B-Vitamins with B-12 Methylcobalamin, 52 percent higher confirming pervasive aspects of this research Uridine, Prebiotic/Probiotic to Manage Inflammation and and analysis. DOI 10.1002/jmri.22517 Factors Produced during Ingestion of some Choline Dense Glycerophosphocho Foods, Enzymes which metabolize these factors or line was 76 percent synthesize these factors as well as precursors to these higher in factors, Water, Phosphatidyl-Monomethylethanolamine Alzheimer’s. (Phosphatidylmonomethylethanolamine or PMME), Oncology and other Human Rubisco, Recombinant Rubisco, Rubisco Agonists pathologies exhibit or Rubisco Modulators, Polyacetylates, similar differences. Phosphatidylethanolamine, Phosphatidylethanolamine Methyltransferase, Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table salt. Factor Indicative Information Information Wholistic Factors to Accompany Therapeutics Calcium. Increased, decreased or Vitamin D, Vitamin K2, inhibitors Increased, decreased or unstable Choline, Trimethylglycine, Folate/Methylfolate, Calcium unstable Calcium levels. of Inducible Nitric Oxide Calcium levels. Typical levels Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, Aggregate Typical levels of Calcium Synthase. Calcium which does not of Calcium are between 10.4 Omega-3 Fatty Acids, Whole Food Organic Vitamins, Diagnostic are between 10.4 mg/dL have a base integrated into it or mg/dL and 8.8 mg/dL. In adults Complete Minerals, Flavonoid/Carotenoid/Phytochemical Assay. and 8.8 mg/dL. In adults most importantly which does not and between 10.7 and 6.7 Supplement, Glandular Mix, KAL SOD3 or other and between 10.7 and 6.7 have Carbonate integrated into or mg/dL in earlier aspects of Antioxidant Mix with Catalase and Superoxide Dismutase, mg/dL in earlier aspects of does not have a factor integrated Development. Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, Development. into that is known to participate in www.reference.com/health/nor Inhibitors of AP-1(x), including Citrus Fruit with www.reference.com/health/ Pathology. Vitamin K2 is mal-calcium-level-blood- Peelings/Rinds, Inhibitors of SP-1(X), Management of normal-calcium-level- considered essential to systemic 3d0a9be38d486e14 Homocysteine, Management of S-Adenosyl Homocysteine blood-3d0a9be38d486e14 management of Calcium although Diagnostic Assay for Calcium. or S-Adenosyl Homocysteine inhibitors, inhibitors of Diagnostic Assay for Vitamin K is pervasively omitted www.labtestsonline.org/underst Inducible Nitric Oxide Synthase, Inhibitors of Uncouple Calcium. or requested to be admitted in anding/analytes/calcium/tab/test Nitric Oxide Synthase and its Reactive Molecular Species www.labtestsonline.org/un progressed Cardiovascular The literature recommends age (L-Arginine, Tetrahydrobiopterin, NADPH, Superoxide derstanding/analytes/calciu Conditions. Similarly, iNOS associated Micrograms per day Dismutase, Catalase, Glutathione, m/tab/test expression produces systems as 2 MCG until 6 Months, 2.5 Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, Calcium Gradients between iNOS until 12 Months, 30 MCG until Complete B-Vitamins with B-12 Methylcobalamin, Uridine, www.pcrm.org/health/healt expression tissues, Bones and 3 annum, 55 until 8 annum, 60 Prebiotic/Probiotic to Manage Inflammation Factors h-topics/a-natural- Digestive obtainment of Calcium. MCG until 13, 75 MCG until 18 Produced during Ingestion of some Choline Dense Foods, approach-to-menopause iNOS depletes store operated for Females, 90 MCG for Enzymes which metabolize these factors or synthesize these Calcium, opens pores in the Females 19 and over, 90 MCG factors as well as precursors to these factors, Water, Endoplasmic Reticulum and for Gestational Carrying Phosphatidyl-Monomethylethanolamine Plasma Membranes, inhibits Females, 75 MCG for Breast (Phosphatidylmonomethylethanolamine or PMME), Human Mitochondrial ATP Synthase, Feeding Females, 75 MG until Rubisco, Recombinant Rubisco, Rubisco Agonists or Depletes iNOS and L-arginine 18 Annum for Males and 120 Rubisco Modulators, Polyacetylates, from extracellular environment, MCG for Males 19 and older. Phosphatidylethanolamine, Phosphatidylethanolamine and Collapses the Sarcolemma. Methyltransferase, Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table salt. Factor Indicative Information Information Wholistic Factors to Accompany Therapeutics Calcium. Antacids, and numerous foods, or www.webmd.com/vitamins Choline, Trimethylglycine, Folate/Methylfolate, Calcium Both Males and Females supplements can exhibit calcium. If -and- Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, Aggregate are known to have about these do not include Vitamin K1 supplements/supplement- Omega-3 Fatty Acids, Whole Food Organic Vitamins, Diagnostic a 100 percent increase in and Vitamin K2, it is not guide-vitamin-k2. High Complete Minerals, Assay. risk for demise when recommended that these be utilized levels of Calcium Flavonoid/Carotenoid/Phytochemical Supplement, levels of Vitamin D are regularly particularly if there is supplements are not Glandular Mix, KAL SOD3 or other Antioxidant Mix below 30 ng/mL, already Cardiovascular conditions strongly recommended with Catalase and Superoxide Dismutase, Choline suggesting that Vitamin exhibited and particularly if Breast unless there is deficiency Kinase Inhibitors, Tyrosine Kinase Inhibitors, Inhibitors D is essential because it Oncology is exhibited. Organ and Vitamin K2 and K1 are of AP-1(x), including Citrus Fruit with Peelings/Rinds, is removed from direct Meats and the Japenese Food Natto included. Inhibitors of SP-1(X), Management of Homocysteine, complexity of K1, K2, are sources of Vitamin K2. Source, Management of S-Adenosyl Homocysteine or S- Cardiovasular disease Protecting Bone and Arterial Adenosyl Homocysteine inhibitors, inhibitors of Management, iNOS and Health with Vitamin K2, Life Inducible Nitric Oxide Synthase, Inhibitors of Uncouple uNOS. DOI Extension Magazine, March 2008. Nitric Oxide Synthase and its Reactive Molecular 10.2105/AJPH.2014.302 Species (L-Arginine, Tetrahydrobiopterin, NADPH, 034 Superoxide Dismutase, Catalase, Glutathione, Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, Complete B-Vitamins with B-12 Methylcobalamin, Uridine, Prebiotic/Probiotic to Manage Inflammation Factors Produced during Ingestion of some Choline Dense Foods, Enzymes which metabolize these factors or synthesize these factors as well as precursors to these factors, Water, Phosphatidyl-Monomethylethanolamine (Phosphatidylmonomethylethanolamine or PMME), Human Rubisco, Recombinant Rubisco, Rubisco Agonists or Rubisco Modulators, Polyacetylates, Phosphatidylethanolamine, Phosphatidylethanolamine Methyltransferase, Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table salt. Factor Indicative Information Wholistic Factors to Accompany Therapeutics Information Insulin Like Growth HER2 and Insulin Tomatoes Choline, Trimethylglycine, Folate/Methylfolate, Glutathione, Factor Like Growth Factor soya polyphenols Probiotic/Prebiotic, Complete-B Vitamins, Omega-3 Fatty Acids, are said to work vegan diet (due to its low protein content). Whole Food Organic Vitamins, Complete Minerals, through Barley is highest in chromium which lowers blood sugar Flavonoid/Carotenoid/Phytochemical Supplement, Glandular Mix, Cyclooxygenase and therefore lower both insulin and ILGF. KAL SOD3 or other Antioxidant Mix with Catalase and Superoxide Protein Tyrosine Breast oncology benefits from decreased levels of Milk as it Dismutase, Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, Kinases but the might increases ILGF, if ILGF is not being managed Inhibitors of AP-1(x), including Citrus Fruit with Peelings/Rinds, literature clearly otherwise. Inhibiting AP-1, TPA/PMA, and inhibiting Inhibitors of SP-1(X), Management of Homocysteine, Management of shows these are Choline Kinase, should impair HER2. Including inhibition S-Adenosyl Homocysteine or S-Adenosyl Homocysteine inhibitors, active through AP- of SP-1 and Protein Kinases should be very effective. IGF-1 inhibitors of Inducible Nitric Oxide Synthase, Inhibitors of Uncouple 1/TPA/PMA Fos/Jun and Insulin both can activate IFGR-1 and IGFR-2, although Nitric Oxide Synthase and its Reactive Molecular Species (L-Arginine, pathways also. IGF-2 integrates with these but does not activate the Insulin Tetrahydrobiopterin, NADPH, Superoxide Dismutase, Catalase, EGF/HER1, the Response Element Genetic Expression Cascade. IGF-1 Glutathione, Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, homologue of activates the Protein Tyrosine Kinase Domains of PI3K and Complete B-Vitamins with B-12 Methylcobalamin, Uridine, HER2, is inhibited AKT, which are on the pathway to AP-1 and TPA/PMA Prebiotic/Probiotic to Manage Inflammation Factors Produced during by Choline Kinase which specifically inhibit PEMT and upregulated Choline Ingestion of some Choline Dense Foods, Enzymes which metabolize Inhibitors Kinase. IGF-1, TNF-Alpha, VEGF and Interluekin-6 each these factors or synthesize these factors as well as precursors to these activate VEGF to produce all manner of Oncological factors, Water, Phosphatidyl-Monomethylethanolamine activity. Downregulation of PEMT, however, seems to the (Phosphatidylmonomethylethanolamine or PMME), Human Rubisco, Plan for Pathogens and Pathogenic Processes Generally. Recombinant Rubisco, Rubisco Agonists or Rubisco Modulators, Brigatinib is an inhibitor of Insulin-Like Growth Factor. Polyacetylates, Phosphatidylethanolamine, Phosphatidylethanolamine www.drugs.com/ppa/brigatinib.html Ceritinib is an Methyltransferase, Methyltetrahydrofolate Reductase, Betaine inhibitor of the IGFR Receptor. Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt www.drugs.com/ppa/ceritinib.html Increlex is a instead of Table salt. supplemental IGFR to manage IGFR. www.drugs.com/ppa/ceritinib.html Factor Indicative Information Information Wholistic Factors to Accompany Therapeutics Orexin and other Hydrogen enriched water increases Ghrelin, Acetylcholine although it has a less potent inhibitory Choline, Trimethylglycine, Folate/Methylfolate, Glutathione, aspects of mechanism, ATP increases, Hyperventilation Bag usage or Breathslim device, Caffeine, Nicotine Probiotic/Prebiotic, Complete-B Vitamins, Omega-3 Fatty Acids, Consciousness only briefly or specifically although it has encompassing Hypothalamic Orexin Potentiation, Whole Food Organic Vitamins, Complete Minerals, Fructose/Fructans/FOS, Oxytocin, Oxytocin, Vasopressin with fluid monitoring, Neurotensin, Flavonoid/Carotenoid/Phytochemical Supplement, Glandular Mix, Omega-3 Fatty Acids except with Narcolepsy, Glutamate only briefly to prevent cognitive KAL SOD3 or other Antioxidant Mix with Catalase and Superoxide impairment, and cholecystokinin although it induces sleep. The article suggests Berberine although Dismutase, Choline Kinase Inhibitors, Tyrosine Kinase Inhibitors, it later suggests that Berberine in inhibits Orexin. Inhibitors of AP-1(x), including Citrus Fruit with Peelings/Rinds, “30 Ways To Naturally Increase Orexin/Hypocretin (and Wakefulness) Inhibitors of SP-1(X), Management of Homocysteine, Management 30 Ways To Naturally Increase Orexin/Hypocretin (and Wakefulness)” The Self ‘Infiltrated’ Internet of S-Adenosyl Homocysteine or S-Adenosyl Homocysteine Blog. inhibitors, inhibitors of Inducible Nitric Oxide Synthase, Inhibitors of Uncouple Nitric Oxide Synthase and its Reactive Molecular Species (L-Arginine, Tetrahydrobiopterin, NADPH, Superoxide Dismutase, Catalase, Glutathione, Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, Complete B-Vitamins with B-12 Methylcobalamin, Uridine, Prebiotic/Probiotic to Manage Inflammation Factors Produced during Ingestion of some Choline Dense Foods, Enzymes which metabolize these factors or synthesize these factors as well as precursors to these factors, Water, Phosphatidyl-Monomethylethanolamine (Phosphatidylmonomethylethanolamine or PMME), Human Rubisco, Recombinant Rubisco, Rubisco Agonists or Rubisco Modulators, Polyacetylates, Phosphatidylethanolamine, Phosphatidylethanolamine Methyltransferase, Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table salt. Factor Indicative Information Information Wholistic Factors to Accompany Therapeutics Orexin and other Paralytic statuses may require management. Potentially helpful considerations include focus on management Choline, Trimethylglycine, Folate/Methylfolate, aspects of pH out of paralytic ranges into functional ranges. This can include provide Choline, Folate, Trimethylglycine, Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, Consciousness Glutathione and L-arginine, along with assuring that Reactive Oxygen Species, iNOS, and Uncoupled Nitric Omega-3 Fatty Acids, Whole Food Organic Vitamins, Oxide Synthase is managed by factors such as L-Arginine, Tumeric, Magnesium, Calcium, strong Ion Complete Minerals, management, Tetrahydrobiopterin, Niacin, Vitamin B-6, Vitamin B-12 Methylcobalamin, NADPH, Choline, Flavonoid/Carotenoid/Phytochemical Supplement, complete group of B Vitamins otherwise, FMO or Flavins, FADH and other factors. Similarly, speaking Glandular Mix, KAL SOD3 or other Antioxidant Mix slightly above eye level, tilting the head and eyebrows upward, and tilting bed at an angle to simulate standing with Catalase and Superoxide Dismutase, Choline positions as a much as possible and providing Orexins which are known to stimulate consciousness. Kinase Inhibitors, Tyrosine Kinase Inhibitors, Inhibitors of AP-1(x), including Citrus Fruit with Peelings/Rinds, Here, additional information regarding Orexins can be provided because such information was not provided in Inhibitors of SP-1(X), Management of Homocysteine, other areas of the Amehsi Specification. An information article regarding Orexins provides information Management of S-Adenosyl Homocysteine or S- presented here. Orexins increase oxygen consumption, thus Oxygen supplementation or mechanical assistance Adenosyl Homocysteine inhibitors, inhibitors of could be useful. Stimulators of Orexins include Ghrelin, inhibition of Inflammation, Curcumin, Boswellia, Inducible Nitric Oxide Synthase, Inhibitors of Uncouple Nicotinamide Riboside NAD+, SIRT1, Tea, Bright Light but not iNOS stimulating versions, Nitric Oxide Synthase and its Reactive Molecular CO2/Lactate/lowered-pH but-not to paralytic levels, Exercise, pyruvate/lactate when Glucose is high enough Species (L-Arginine, Tetrahydrobiopterin, NADPH, to suppress Orexin response, Micropulse Device, Infrared, Low Level Laser Therapy (LLLT) and Superoxide Dismutase, Catalase, Glutathione, Photobiomodulation, utilize fermented nutritional factors, Kombucha, Sauer Kraut, Pickles, Probiotics such as Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, Lactobacilli, Calcium Lactate, Calcium Pyruvate, Magnesium Lactate, manage/decrease Glucose, decrease Complete B-Vitamins with B-12 Methylcobalamin, obesity associated increases in Leptin which inhibits Orexin, Fiber, Agonists of GLP-1 which activates/excite Uridine, Prebiotic/Probiotic to Manage Inflammation Orexin Neurons, Prebiotics/Resistant-Starches, Hi-Maize as a Resistant Starch, exhibit enjoyable activities, Factors Produced during Ingestion of some Choline Dopamine Agonists while inhibiting the Dopamine Receptor, L-Dopa, Mucuna, Modafinil, Amphetamines, Dense Foods, Enzymes which metabolize these factors Tyrosine, S-Adenosyl Methionine with an additional ATP molecule SAM-E, Golden Root/Rose Root/Artic or synthesize these factors as well as precursors to these Root, Longvida Curcumin, Forskolin, Cyclic AMP, Pregnenolone, GABA Agonists, Progesterone, DHEA, factors, Water, Phosphatidyl-Monomethylethanolamine DHEA-S, Ginkgo/Bilobalide, Ginkgolide, Zinc, Wormwood or Thujone from Sage, Muira Puama, Naltrexone, (Phosphatidylmonomethylethanolamine or PMME), Theobromine, Theophylline, Antibiotic Beta-Lactams such as Penicillin's/Cephalosporins/Carbapenems, and Human Rubisco, Recombinant Rubisco, Rubisco Thyroid Releasing Hormone. Adenosine cycles to potentiate wakefulness and sleepiness, such that decreased Agonists or Rubisco Modulators, Polyacetylates, levels of Adenosine potentiate reestablishment of consciousness. Phosphatidylethanolamine, Phosphatidylethanolamine Methyltransferase, Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table salt. Factor Indicator, Primary Information Wholistic Factors to Accompany Therapeutics Other indicators Vital Indicators are 1. Others include, Eicosapentaenoic Acid (Neutralization of Arachidonic Acid Choline, Trimethylglycine, Folate/Methylfolate, always necessary Metabolites) Glutathione, Probiotic/Prebiotic, Complete-B Vitamins, including those not 2. Arachidonic Acid (When High Increased Leukotriene, Thromboxane, Omega-3 Fatty Acids, Whole Food Organic Vitamins, exhibited here, and Prostaglandin Potential) Complete Minerals, including those presented 3. Omega-3 to Omega-6 Ratio Flavonoid/Carotenoid/Phytochemical Supplement, in the list of indicators 4. Trimethylamine to Trimethylamine-N-Oxide Ratio Glandular Mix, KAL SOD3 or other Antioxidant Mix presented in the early 5. Circulating Calcium with Catalase and Superoxide Dismutase, Choline Kinase aspects of this 6. Calcium Inhibitors, Tyrosine Kinase Inhibitors, Inhibitors of AP- presentation. 7. Potassium 1(x), including Citrus Fruit with Peelings/Rinds, 8. Oxygen Inhibitors of SP-1(X), Management of Homocysteine, 9. Pulse Management of S-Adenosyl Homocysteine or S- 10. Systolic/Diastolic Pressure Adenosyl Homocysteine inhibitors, inhibitors of 11. Strong Ions, Fluids, Electrolytes, Inclusion Choline and Folate in Parenteral Inducible Nitric Oxide Synthase, Inhibitors of Uncouple Nutrition Nitric Oxide Synthase and its Reactive Molecular 12. White Blood Cellular Entities or Leukocytes Species (L-Arginine, Tetrahydrobiopterin, NADPH, 13. Glucose Superoxide Dismutase, Catalase, Glutathione, 14. HCO3- Citrulline/Arginine/Ornithine), NAD+, Hyaluronic Acid, 15. H2S Complete B-Vitamins with B-12 Methylcobalamin, 16. Superoxide O2- Uridine, Prebiotic/Probiotic to Manage Inflammation 17. H202 Hydrogen Peroxide Factors Produced during Ingestion of some Choline 18. CO2 Dense Foods, Enzymes which metabolize these factors or 19. Catalase synthesize these factors as well as precursors to these 20. PCBs factors, Water, Phosphatidyl-Monomethylethanolamine 21. Choline-O-Acetyltransferase (Phosphatidylmonomethylethanolamine or PMME), 22. Free Phosphorylated Choline as Phosphocholine Human Rubisco, Recombinant Rubisco, Rubisco 23. TNF-alpha Agonists or Rubisco Modulators, Polyacetylates, 24. Thromboxane Phosphatidylethanolamine, Phosphatidylethanolamine 25. Temperature Methyltransferase, Methyltetrahydrofolate Reductase, 26. Leukotrienes Betaine Homocysteine Methyltransferase, Ancient Pink 27. Prostaglandins Himalayan Sea Salt instead of Table salt. 28. NF kB 29. Interleukins 1B and other Interleukins or aggregate 30. Interferon individual or aggregate Interferon Factor Indicative Information Wholistic Factors to Accompany Information Therapeutics Other Vital Indicators 1. Others include, Eicosapentaenoic Acid (Neutralization of Arachidonic Acid Choline, Trimethylglycine, Folate/Methylfolate, Indicators are always Trimethylamine/Trimethylamine-N-Oxide Ratio (Uncoupled/Inducible NOS, Homocysteine Glutathione, Probiotic/Prebiotic, Complete-B necessary Homologue) Vitamins, Omega-3 Fatty Acids, Whole Food including 2. Phosphatidylethanolamine Methyltransferase (Increased P53, Lower VLDL unless Liver X Organic Vitamins, Complete Minerals, those not Receptor Rescues) Flavonoid/Carotenoid/Phytochemical Supplement, exhibited here, 3. VLDL (When Low, Impaired Phosphatidylethanolamine Methyltransferase, possible Liver X Glandular Mix, KAL SOD3 or other Antioxidant and including Receptor Impairment) Mix with Catalase and Superoxide Dismutase, those 4. Phosphocholine (Feed Forward Energy Accumulates for Oncology and Pathology) Choline Kinase Inhibitors, Tyrosine Kinase presented in 5. Dioxins Inhibitors, Inhibitors of AP-1(x), including Citrus the list of 6. Reactive Carbonyls Fruit with Peelings/Rinds, Inhibitors of SP-1(X), indicators 7. Oxidation of Lipids Management of Homocysteine, Management of S- presented in 8. Advanced End Products Adenosyl Homocysteine or S-Adenosyl the early 9. HB1AC Glycosylated Levels Homocysteine inhibitors, inhibitors of Inducible aspects of this 10. HB1AC Duration of Glycosylation Nitric Oxide Synthase, Inhibitors of Uncouple Nitric presentation. 11. Is the Patient Located in Locality, Region or Area that uses Demise as a Sanction Oxide Synthase and its Reactive Molecular Species 12. Does the Patient Speak English (L-Arginine, Tetrahydrobiopterin, NADPH, 13. Is there an information System that indicates Abated Vital Being, Continued Vital Being or Superoxide Dismutase, Catalase, Glutathione, Prognosis Citrulline/Arginine/Ornithine), NAD+, Hyaluronic 14. Is there a Detailed Financial Information System that Includes Clinical Billing Information, Acid, Complete B-Vitamins with B-12 Clinical Information, the Patients Identifying Information and is it onsite with the Care Methylcobalamin, Uridine, Prebiotic/Probiotic to Entity? Manage Inflammation Factors Produced during 15. Does the Patient have Health Coverage Ingestion of some Choline Dense Foods, Enzymes 16. Is the Patient socioeconomically Advantaged or Disadvantaged which metabolize these factors or synthesize these 17. Are information systems utilized to distribute Statistical Information about Human factors as well as precursors to these factors, Water, Outcomes? Phosphatidyl-Monomethylethanolamine 18. Are there any objectives, budgets or projections that require or benefit from the exhibition of (Phosphatidylmonomethylethanolamine or PMME), detrimental Human Outcomes? Human Rubisco, Recombinant Rubisco, Rubisco 19. Other factors in the Amehsi Health Framework Care Checklist Agonists or Rubisco Modulators, Polyacetylates, 20. Other Factors in the AMEH Healthnet Framework Super Indicators or Ubermarkers Checklist Phosphatidylethanolamine, 21. Factors which remediated/Remediate these within the Amehsi Specification Phosphatidylethanolamine Methyltransferase, 22. pH, Temperature, Pulse or Heart Pace, Oxidation or levels Oxygen, Levels of CO2. Methyltetrahydrofolate Reductase, Betaine Homocysteine Methyltransferase, Ancient Pink Himalayan Sea Salt instead of Table salt. Factor Indicative Information Information

Amehsi Assists in 1. An information technology system and activity process that has patients authenticated using DNA at the care setting, while Capabilities translating Amehsi each diagnostic sample is also authenticated using DNA, such that each phase of a care process is assured to be accurate along Recommendations with assuring authenticity of Diagnostic Samples and their application to Care. , information and 2. Information Technology System which maps each care intervention, patient, diagnosis, disease, diagnostic and possibly other information procedure to their precise causal factors within the Amehsi Information Framework. The objective is to continue the into improved progression of how ICD improves behavior and biological outcomes without adversely effecting Human physiology and behavior. outcomes. 3. A Care Management Capability which maintains information about each diagnostic test or diagnostic determination, particularly Amehsi Factors, including if they were effective and if they effect Amehsi Indicators in an adverse way, such that providers can observe how each therapeutic effects Amehsi Indicators. The capability enables iterative progressive improvement of therapeutics and management of Amehsi indicators to optimal levels. 4. A Care Management Module which enables Health Plans, Research Entities, Care Entities, or any other role in the Health Industry to obtain information about Amehsi Indicators or other Indicators such that patient status, physician usage of the indicators, effect of indicator management, may be utilized to improve programs, product/plan performance, service quality, and financial performance, and as well as provide information for Pay for Performance initiatives or prospective payment systems which do not rely upon Fee for Service structure. 5. A algorithm, Services and Software Module which enables Pharmaceutical, Therapeutics, Services and Product organizations to determine how their prospective or already implemented capability effects Amehsi Indicators as well as provides a map of how to improve the performance of such capabilities using Amehsi Indicators. An algorithm and technology capability that enables interactions that transcend distance, location, space and time, particularly in effecting care, behavior and physiological outcomes. 7. A Capability that uses phase transfer and shaping influences to mitigate concussive influence that might be detrimental to structures and physiology. 8. A propulsion system that uses the model of Inducible Nitric Oxide Synthase and its possible substrates, as well as how iNOS produces mechanical force through its consumption of Ca2+ by opening apertures in cellular membranes. Factor Indicative Information Wholistic Information Factors to Accompany Therapeutics Amehsi Assists in 9. A Dynamic information exchange solution that enables associations in different clinical and technology codesets, Capabilities translating molecular pathways, metabolic pathways, behavior, disease, and outcomes to be automatically generated from Care Amehsi and Clinical Systems, followed by automatically offering these capabilities as consumable information in an industry Recommendatio network. Each association can be included in research, development, and care. Each service can immediately benefit ns, information a capability being produced and included in the development costs as well as included in the wholesale or retail and other pricing scheme. Similarly such associations can be included in cost of care and reimbursed in the care payment information into scheme. The solution is the first IP assurance capability that enables organizations to benefit from the way in which improved they enhance progressive improvement in technology and health outcomes. outcomes. 10. Amehsi Information Systems Architecture, Development, Management and Improvement Modules, Services and Guidance including guidance for EMF Protection in communities, dwellings, edifices and care environment 11. Custom Supplements for each Health Condition or Patient derived from Amehsi Information, Health and Beauty Therapeutics, as well as Biomedical/Supplement capability schedules for use in care, health and beauty. 12. Guidance for improving performance systems of civilization, including assuring prioritization of optimal Human Outcomes. 13. Computational Proteomics molecule that includes numerous Biomedical/Supplemental Capabilities interspaced by molecular domains that are segmented only by particular conditions in cellular environments as well as which are segmented by proteomic diagnostics molecular capabilities. Molecular diagnostics can test for a condition or status then produced the segmenting factor when the diagnostic condition or status is found. 14.A system of Biomedical and Supplemental capabilities in which the computational molecular domains are progressively improved. Biomedical capabilities and supplements are produced or developed separately without having to resolve how to obtain optimal intracellular molarity or specificity of applicability to the Patient. Diagnostic capabilities are produced and progressively improved, which produce catalytically active segmentation factors that segment specific domains in the computation Proteomics molecules. Manufacturing of biomedical or supplemental capabilities then includes Computational Molecular Domains as already produced infrastructure, while different biomedical/supplemental capabilities are produce for inclusion between the segmentable domains, while diagnostic capabilities can be included in the molecule or exhibited separately from the Computational Proteomic Capability such that therapeutics are released when very precise factors, conditions, characteristics, enzymes, molarity, turgor, temperature or other characteristics are exhibited. The system enables precision in therapeutics, increase of entrants into the therapeutic market, assurance of optimal pharmacokinetics, decrease development costs, decrease risks as well as enables Amehsi Indicators to be utilized in development capabilities with near 100 percent effectiveness. 15.Use of Phospholipid and Monomethylethanolamine Metabolites to promote enhance crop production and deteriorate toxins. 16.The implementation of Software Defect Management System using the Amehsi Care Amehsi Care Information Tuple Patents and Trademarks Apply to this Material and all Amehsi Material The Amehsi Specification Risk Mitigation information Tuple First Artifact of Three Choline, Folate, Methylcobalamin, Cobalamin, Adenosylcobalamin, Complete B Vitamin, Trimethylglycine, Glutathione, L-arginine, Tetrahydrobiopterin, Phosphatidylcholine, Phosphatidylmonomethylethanolamine, Phosphatidyldimethylethanolamine, dimethylethanolamine, Lysophosphatidylcholine,, low dosage Omega-3 Microalgae or Coldwater Arctic DHA/EPA, Kidney Stuff from Goldenstandards, S.O.D.3 from KAL,, Enterex Diabetic Drink because among Diabetic Nutritional Supplements it has among the lowest inclusion of risk factors which potentiate soft tissue calcification and Oncology of Breast, N-Acetyl-L-Cysteine, Choline, S-Methylmethionine, S – Adenosyl Methionine, Folate, Methylcobalamin, Cobalamin, Adenosylcobalamin, Complete B Vitamin, Trimethylglycine, Glutathione, Red Sage, Thetin exhibiting Supplements (Dimethylacetothetin, Dimethylsulfonioacetate, Ethylmethylthetin, Dimethyl-Alpha-Propiothetin, Dimethyl-beta-Propiothetin, Ethylmethyl-Beta-Proprothetin, Dimethyl-Gamma-Butyrophenone, Methionine Methylsulfonium, Trimethylsulfonium, Butyldimethylsulfonium, or Ethyldimethylsulfonium), Iron, Mg2+, Zinc, Riboflavin, Magnesium, B12 Methylcobalamin, Vitamin B6, 5,6,7,8 Tetrahydrofolate, Low dosage S-Adenosyl Methionine, Calcium only with Vitamin K2, Cationic Diatomic Metal Ions, Glycine, Garcinia Kola Seed Extract, Fruity Olive Oil, Balsamic Vinegar, Probiotic, Prebiotic, Diverse Coverage Antibiotic during an Emergency or three courses each year, Gastrazyme by Biotics Research, Customcapsule.com Standard Supl A and Standard Supl B, while adding Curcumin, Berberine, Adenosine, for progressed conditions. Unless there is a deep tissue injury requiring improved Turgor of Cellular Entities to maintain spatial aspects of tissue regeneration, Calmodulin and Calcium Complex to enable Endothelial Nitric Oxide Synthase and Neuronal Nitric Oxide access to Calcium while preventing Inducible Nitric Oxide Synthase Access to Calcium because iNOS has Calmodulin already integrated into its structure and eNOS as well as nNOS integrate Calcium and Calmodulin dynamically during Enzymic Activity. Request that one’s Health Provider whom prioritizes keeping Homocysteine below 7 Micromoles per Liter with 1 Micromole or less being optimal, as was whom monitors/manages Trimethylamine-N-Oxide. Flavonoid/Carotenoid Balance for optimal Membrane Ph. Water, complete phytochemical supplement, complete mineral supplement, inclusive Vitamin Supplement, Coenzyme Q10, complete Ribonucleic Acid supplement, Adenine, Ribose, Deoxyribose, Choline Kinase Inhibitor, Inhibitor of Factors that inhibit Phosphatidylcholine Methyltransferase, Lysophosphatidylcholine, DHA Enriched Lysophosphatidylcholine, DHA Enriched Phosphatidylcholine, inclusive branched and other Amino acids supplement, for optimal phospholipid, Cholesterol and lipid membrane phase transitions. Methylsulfonylmethane, Bone Powder Supplement, and complete Glandular Supplement by Traditional Foods, for optimal marrow, hepatic, renal, and other Glandular and Splanchnic Function, particular with Bone conditions marrow conditions. Hpmpc/Vistide viral DNA Polymerase inhibitor, AP1 inhibitor or berberine, sp1 inhibitor or curcumin, Inducible Nitric Oxide Inhibitors, or curcumin, omega-3, Tetrahydrobiopterin or Pteridin-4 for viral Oncology, with Harvoni for Hepatic Viral Oncology. C Reactive Protein Management. Rubisco or Ribulose Carboxylase/Decarboxylase Supplement. Delta 4 and Delta 5 Desaturase with assurance that omega-3 supplement is a 4 to 1 Ratio compared with Omega-6, because Omega-6 is such a large aspect of Western Nutrition. Crispr Perfect Gene Repair to repair DNA, Excise Viral DNA, and Specifically Manage detrimental Microbes. Diverse Phytochemical Supplement to assure optimal Lipid, Phospholipid and Cholesterol Phase Transitions in synthesis of Physiological Superstructure. Use Bottled, Filtered or Boxed Water. Use increased levels of Phosphatidylserine and inhibitors of Antiphosphatidylserine Immunoglobulin to assist in managing impaired coagulation or unmanaged flow of Haemopoietic Fluid. Omit Phenylalanine from Amino Acids if Phenylketonuria is exhibited, and if Ketoacidosis Risk is exhibited omit Ketogenic Amino Acids Lysine and Leucine while also considering decreasing supplementation of Ketogenic Potentiating Phenylalanine, Isoleucine, Threonine, Tryptophan and Tyrosine although it is possible that Choline supplementation can decrease the level to which pyruvate is influenced toward alanine by Ketogenic Amino Acids. Ribulose 1,5 Bisphosphate is a Ketone and is metabolized by Rubisco Enzymes, suggesting that Rubisco may help alleviate at least 1 Ketone’s accumulation as it supplies biosynthetic precursors to pathways vulnerable to Choline deficiency and vulnerable to inhibition of the Enzyme PEMT. Fine Ancient Pink Himalayan Sea Salt at about half teaspoon each day. Obtain and use Coenzyme Q10. Home health, Physical therapy, occupational therapy, Hygiene Assistance, Home Cleaning Assistance, Assistance in mixing/providing/Serving Supplemental and Biomedical Capabilities. Consultants or assistances to performance water, energy, particular factor testing, documentation and mitigation. Incentives to encourage health consumers to comply with supplemental and biomedical regimens. Inorganic Phosphorus, Inorganic Pyrophosphate and Dolichol (Arctic Fir Tree Extract, the Pharmaceutical Factor Ropren, or Spinach) P to alleviate Ataxia Conditions or Conditions in which movement or coordination of movement is impaired such as Myasthenia Gravis, Alzheimer's, Parkinson’s, Amyotrophic Lateral Sclerosis, Multiple Sclerosis of Developmental Conditions. Multiple instances daily, Successively Cover both Eyes completely, then Both Ears Tightly, then follow this be pinching the nostrils with both hands enough to be sure that the entrance into the Cerebral Structures behind the Nose Cartilage are impeded, followed by covering the back of the next completely to obscure access to the Spine, while subsequently covering the 5 inches of spine in the upper Back right below the Neck to disrupt the fields and moments of influence which flow through or are shaped by the Central Neurological System.. The Amehsi Specification Risk Mitigation information Tuple, Second Artifact of Three

Cover all of the power outlets and communications outlets preferentially with Electromagnetic Frequency Managing Material. Insulating Power and Communications Conduits and Wiring in Homes, Buildings and Environment with Electromagnetic Frequency inhibiting Material. Removing personal communications, locations and addresses from internet information systems and using alternate locations or addresses in information systems to prevent contiguous interactions in environmental fields encompassing civilization. Cover computing devices with Electromagnetic Absorbent cloth, paint or material, or place such factors inside of the computing devices in a recommended way. Disable remote registry service on computing device, disable remote connection or desktop services. Remove all services from Network Card Properties except those which are necessary including TCPIP services in particular. Remove all of the known, saved or remembered Wifi Networks. Use wired computer connections instead of wireless or use dialup connections for internet services if possible. Cover mobile phones with an electromagnetic energy protective cover. Make sure to regular review firewall application filtering because new applications may emerge and many firewalls allow outgoing and ingoing connects for any new services, such that review of settings to assure disablement of applications must be performed except for internet browsers, dll hosts, application host, browser content services, which often have to enabled for internet services to function. Place Electromagnetic Energy suppression, disruption or inhibiting devices in locations where detrimental outcomes occur. Cover and enclose material, writing, consumer product packaging and literature in areas where fields in the environment, dense energy or communications fields, wireless networks, and other factors may be located, including dwellings. Mark all unknown emails as Junk, then block the senders briefly, and then reclear the safe senders, email lists and blocked emails list. Change all addresses and locations in social network and email address to not use one’s actual location. Turn off or disable any time-zone indicators in email and social networks. Remove any groups or companies or followings in social networks as these may be used to affect behavior and physiology. If publishing documents or sharing artifacts on the internet, use a dedicated computer, change the computer and user account name after every publishing activity, and disconnect the computer from the internet when not publishing or sharing artifacts because CPU, Computer, Username, Mac Address and IP can be included in the document to encompass users increasedly deterministic and increasingly dense fields for correlation, associations and physiological/behavioral influence. Close email and social networking accounts. Turn of mobile computing and communications such as Wifi, wireless communications otherwise, or device to device protocols, Locations, Cellular Data and Mobile Voice service. Disable cameras, microphones, location services and telemetry on mobile, communications and computing devices. Keep identification in a safe or safety deposit box, or at least in a nonvisible container or enclosed container unless required for specific activity. Always observe, Assay or Test Diastolic and Systolic Pressurization on Left and Right, comparing each such that more than 10 mm/Hg difference between Left and Right and certainly a difference of more than 15 mm Hg, indicates substantial levels of Risk. Configure firewall outgoing rules on computers to allow only outgoing DNS, DHCP, and each application which requires access to the Internet such internet browser and mail clients or other. Remove batteries, power outage tools such as Power Packs containing energy or large Batteries, cover these with EMF Safe Material. Do not obtain and utilize for more than 1 Month any Amino Acid Supplement or product containing Amino Acid unless the product has at least 400 and optimally 800 milligrams of Raw uncooked Choline along with 100 Milligrams at a Minimum and optimally 250 Milligrams of Betaine as Trimethylglycine. Studies show that Amino Acid Supplementation without Choline causes 100 Percent incidence of Oncology in Small Mammals when supplemented for more than 1 month, along with 4 months being require for Oncology to emerge, and along with 100 Percent Incidence at 12 Months. Although the use of steroids has typically been presented as the cause of Oncology in users of Steroids, it is likely that Choline Deficiency which is the incipient cause of pervasive pathology along with Amino Acid Supplementation which is common on users of Performance Enhancing Supplements may have been essential, participatory, or most causal. The Amehsi Specification Risk Mitigation information Tuple, Second Artifact of Three

Disable the COM and USB Ports in the Device Control Panel of your Computer Device. Obtain Electromagnetic Frequency Protection Dots or Stickers, such as Quwave Quantum Scalar Shield, and place these on all windows of the Home with artistic interface toward the outside of the Home and all devices in the Home. Place one on the inside and outside of every window, as well as on every device. Place Electromagnetic Frequency Protective Material between the Home and any energy transfer devices attached to dwellings or buildings as well as between the Home and any location where energy or communications lines enter structures. Wear Electromagnetic Frequency Protective Clothing, helmets, eye coverings, ear coverings, socks or veils during sleep, during hours of most prevalent adverse health events from mid Morning to 12 Noon as well as from about Late afternoon to mid evening to prevent iNOS and uNOS as well as Trimethylamine-N-Oxide from causing Sudden Adverse Health Events as well as causing abated Vital Being that is inaccurately observed to be from Natural Causes. Complete the Amehsi Behavioral and Environmental Assessment. Test water and atmosphere for particulate factors including Nitrosamine, Arsenic, Chlorine, Fluorine, Lead, Mercury, Spores, Vital, Bacterial, Archea, Microbes or other factors, requiring filtering or use of other sources. Request an electromagnetic safe room, area, or location to receive care and for use a dwelling or choose locations which are free of synthetic fields or particulate factors to obtain care or as a holiday from such influence, being sure to not utilize mobile devices, internet connections, or distribute information about ones location when using such safe areas. Imperatively, in Homes, Dwellings or Buildings as well as in open and outdoor environments, cover all power extension lines, energy outlet/plug multiplier, Uninterruptable Power Supply/Multiplier, or Surge Protectors with electromagnetic, all with Electromagnetic Safe Coverings, in Electromagnetic Safe Bags, or a minimal with Cloth or enclosed structures which are Resistant to Combustive Influences. Faraday Bags and Enclosures can be used to encapsulate power devices, surge protectors, power cords, and wrap devices such as computing devices, particularly with finely perforated areas to enable ventilation. A useful test is to randomly integrate recommended changes until oneself and others are able to consciously perform supplement, nutritional, and exercise routines without substantial inclination or occurrence of disruptive influences that prevent the routine from being perform consistently. Some instances, when cognition and physiology improves, health consumers can have spontaneous inclination to abate, disrupt or discontinue therapy, requiring that persistent adherence be maintained as these factors are the principal causes of all pathology. Exercise each day which includes 2 groups or sets of squatting, 2 groups of fully extending arms outward against a wall or against resistance, bending of legs such that heel comes as near as possible to the Gluteus Maximus, and walking or lightly running in place, while varying each week between 8 repetitions, 10 repetitions and 12 for the 2 groups or sets of each exercise performed. Remove the Publication on the internet or exhibition in internet systems of interpersonal, marital, offspring and other relationships because these can be used by patterns within systems to cause detrimental outcomes and increasingly mitigate Choline/CDP-Ethanolamine Pathway enhancement of physiological and behavioral outcomes. Tideglusib or natural and synthetic inhibitors of GSK-3 and inhibitors of CDK which enable regeneration of Dental Structure for limited duration only, or management of PEMT, Homocysteine, Choline Kinase, AP-1, SP-1, Choline, Folate to achieve regeneration of Dental Structure. The Amehsi Specification Risk Mitigation information Tuple, Second Artifact of Three

Substantial detriment to physiology, changes to behavior, susceptibility to adverse behavior, susceptibility to compulsions and Addiction, as well as increase in chronic discomfort, all can occur from victimization patterns in internet systems. In the File, Options, Mail, Send Mail Options in your email client application, or elsewhere in your email determined by searching the internet or asking the vendor, empty or delete the recipient Cache. In the online web interface, emptying of the recipient cache requires unselecting the ‘suggest recipients’ property in the suggest send mail or recipients list. Also, it has been found that some web interfaces allow suggested recipients to be seen in subsection of the Contacts list or People link followed by Selecting the Properties list from the Top Left of the Contacts Web Interface to show Suggested. Use a search engine or ask the Vendor for your internet solution how to find the areas for suggested recipients. Suggested recipients these might not be able to be managed or deleted from this interface. It is sometimes necessary to open a new email for sending, then place the cursor into or click into the To area where a recipient is to be entered, which should cause a list of suggested recipients to be exhibited. Placing the cursor over any of the recipients should cause a delete option to be exhibited somewhere in the suggested recipients information, thereby enabling deletion of the recipient. However, each recipient has to be deleted individually from the Web Interface if the feature itself is not disabled or cannot be disabled. Once a list is completely deleted, replace the cursor into the To area and click once again to enumerate other suggested recipients for deletion, repeating this process until no more recipients are enumerated. Typing in the letters of the alpha beta, then, has to be used to enumerate other recipients by beginning letter. Once all the recipients enumerated by an individual letter of the alphabet being placed into the To Field, then it is required to use another or subsequent letter of the alphabet. Testing of this Method resulted in having to use multiple letters because website seemed to be hiding recipients which have a beginning letter that has already been typed into the To recipient field but were not enumerated into multiple letters of the Alphabet were placed into it. After enough of the possible combination of letters are entered to make it reasonably ascertainable that the list has been emptied, close the email interface and log in again, and repeat this process, because these analyses have found that email addresses sometimes were again exhibited or new email recipients were found which were not exhibited before. Similarly, these analyses found that removing email addresses from the blocked recipients list, safe recipients list and recipient lists, followed be removing all recipients from the People or Contacts exhibited strong changes to behavior, such that these lists seemed to be abdicating control to the recipients list in them instead of merely changing how messages are sent and received. Most imperatively, we found that the Email systems online Web User Interface and sometimes the email Client can sometimes already be configured to save every recipient including those whom are sending email to the user of the email system, which seems egregious if all of these other configuration data do not seem egregious. The Amehsi Specification Risk Mitigation information Tuple, Second Artifact of Three

Disabling suggested recipients in the email client and online web user interface seems to be the only way to prevent this. However, when the saving of all recipients, saving of email attachments of each of the email user’s messages which at this instance seems to be unable to be prevented, along with saving of email messages, all were considered along with all the suggestions functionality in applications, internet browsers, mobile phones, mobile applications, etc., it was found that an egregious systems of artificial intelligence was created in which companies could synthesize a user of internet systems and project the knowledge, skills and abilities into their own workers or into factional leaders in online social network hierarchies in ways that included denying opportunity for users, using the knowledge and documents of users, as well as integrally interacting with the neurological synapse of internet users. However, disabling suggested answers, internet browser history, suggested completions of search text, autocompleted in internet web browsers, desktop applications, mobile hone applications, mobile phones, seems to be important considerations because these clearly show that merely sending an advertising or suggestive email to an internet user can change a user behavior and promote dissociative behavioral patterns as well as promote dissociation of decision-making and behavior from reason. Moreover, because these systems are encompassing influences it is somewhat certain that these are causal factors to detrimental outcomes among those whom performs services for systems and organizations of civilization, those whom receive services from organizations, outcomes which require sanctions, compulsive addictive behavior, epidemics or pandemics which include a behavioral factor to a physiological or behavioral outcome, decision-making which can be shown to occur at 90% or more within less than conscious function. The unexplained detrimental behavior being exhibited by citizens of nations, people acting within systems of civilizations, particular aspects of medical iatrogenesis, seem to be the result of a direct application of these compulsion mechanisms or similar compulsion mechanisms exhibited in earlier information systems as well as earlier systems of influence including Cultural, literature, or other system which preceded the exhibition of modern technology. People and families exhibiting detrimental behavior, addiction, behavioral health conditions, and other conditions such purchase electromagnetic frequency management material, clothing, and coverings for energy fields, computer devices, mobile phones, electrical outlets, and consumer electronic/electrical devices as well as turn of suggested and delete lists of suggested recipients, remove/disable internet browser history or remove/disable history from all computer/mobile device applications, as well as consider these to be as detrimental to physiology and behavioral as the most potent of detrimental molecules. These represent the most powerful and potentially most detrimental system of influence to Human behavior and Physiology in the span of the Human experience. A encompassing systems of susceptibility which is layer upon the contexts of Choline inadequacy, Trimethylamine-N-Oxide, Homocysteine and Roemer’s Law, followed the exhibition of systems with required associations and activities, along with exposure to detrimental outcomes, unresolved although resolvable detrimental circumstances, and the allowing of individuals, systems or organizations to obtain benefit from outcomes which occur resultant such layers of influence. This seems like a system of scapegoatism in which detrimental human outcomes may be being caused to persist or allowed to persist as fodder for organizations to achieve objectives and compete in international markets which are not required to be tightly integrated into any permutations of reason which maintain Human Priority, such as those aspect of reason which flow from philosophical, regional, national or other contexts in a system of civilization that pervasively asserts Human priority over the system of civilization itself and the encounterances which occur within such civilization. This represents a sale and marketing system which permeates physiology and is transformed into somatic, cognitive, and behavioral control which has outcomes beneficial to organizations and systems as its controller.

It is not far fetched to present that such systems of susceptibility could be able to suggest and cause the progression of the cellular cycle or impairment of cellular cycle which is enabling of, causal to, or constitutive of Oncology. Certainly, these systems have already been shown to be able to modulate or change each of the 10 or more Priority diagnostic and indicative factors required for Oncology and Pervasive causality, although these factors seem to be disjoint in distance, location, space and time from constituting such pathology wholly. Correlatively, even those factors considered to be most causal to Oncology and Pathology, each seem to be also have equally disjoint characteristics in the way which these may be causal to detrimental Human physiological and behavioral outcomes. The Amehsi Specification Risk Mitigation information Tuple, Third Artifact of Three

Cover all power, communications and energy outlets or plugs in the Dwellings, Buildings, or Outside, then plug in devices through the covering or through the tape or material which is covering the outlets. Also, develop power or energy outlets and plugs that have coverings which are EMF Safe and have coverings which can be opened and closed. Develop power plugs or energy outlets which are separated from wiring supplying energy or power until the prongs of a device or until a device has been plugged in or connected, thereby only opening the EMF insulated separator when a device has been connected to obtain energy. Cover energy and communications outlets in areas where compulsive or addictive behavior is exhibited such as Kitchen, areas allocated for particular addictive or compulsive activity. Also focus on the location of Energy, Power and Communications devices in dwellings and areas were sleep occurs, with attention to correlate locations of such outlets and location of particular pathologies in the Physiology of those using such buildings and dwellings. Prevent deterministic factors which cause detrimental physiological and behavioral outcomes by abating the cyclical influence actuarial and statistical information. Close and Freeze all Credit Information and files as well as change all addresses to alternative addresses other than dwellings or location which are most utilized. Try to prevent the publishing of any credit, financial or other accounts and information on internet websites, and if such information is placed on the internet, use an alternate address as well as do not use an email address, or be sure that the email address utilized does not maintain specific address, phone, or location information. In any information systems, require that system indicate that the first language is any language other English if you are in English speaking Region, particularly because non-English Speaking Patients escape the deterministic influence of Information Systems during less than Conscious Status which potentiates adherence to the status quo with regard to outcomes during adverse health events as well as during adverse behavioral events. Indicate that the address for patients or for a person obtaining care is in a region, location, or nation which does not utilize the Abatement of Vital Being as a Sanction. Request that phone numbers and addresses be unpublished in directories such as phone books or internet directories. Demand that internet sites which are accumulating and offering information about individuals and those whom they are associated stop producing such associations, remove such information from their systems and not provide such information to anyone. If applying for a trademark or Patent request that the Patent be unpublished and not available for search, while also requesting the personal information such as name, address, phone and email address also be unpublished. Require that your communication service provider or internet service provider, including computers, phones, mobile devices, or devices otherwise, provide a proxy address or use an internet IP address that is very, very distant from your actual location, as well as assure that such distant location is not susceptible to increase detrimental outcomes, patterns, traps, increased pathology or increased detrimental behavioral outcomes. Access all your social network, employment resume, or other websites only when using such distant proxy addresses. Also, request that any application using locational information perform locational processing on the client device as complete local application or by processing the location locally then supplying application content relative a location and within a reliable radius of the location. Avoid open, synchronous, continuously updating interactions between a client device or application and an Internet/Intranet Application Server or Middleware, because these open an interactive Synapse that increase the ability intercept, track, compromise, or change communications including Location. Such synapse can be utilized to change perception, change behavior, affect individuals, groups or populations, as well as imperil such individuals, groups or populations. Location information should be ameliorated by securing algorithms, particularly if being sent over internetworks, and should be accessed by third parties at the Internet Server before Content is supplied to user or user’s device. Avoid having open communications synapses between multiple different applications from different content providers which all are using Location information because these can cause confusion, change behavior and cause accidents, as well as become intercepted or compromised to imperil users. Always dissociate IP address, Client Communications Pathways and Locational information in Programming and Business Logic, as well as implemented Asynchronous interactions to prevent a physiological, cognitive, and behavioral synapse from emerging between an internet content server and the user, as well as to prevent a such a synapses from emerging between devices and users, because invariably, such influence may upregulated iNOS and other inflammation pathways within a user whom has an unknown physiological status. Use Duct Tape and EMF inhibiting Tape to repair Perforations or Openings in Computers, as well as to cover external communications ports or connection areas of Computers, Mobile Devices, Communications Devices, or Phones. Faraday Bags and Custom Faraday Energy trapping Enclosures can be purchased and designed to meet numerous specifications to prevent exposed power strips, surge protectors or extension cords. The Amehsi Specification Risk Mitigation information Tuple, Third Artifact of Three

If Trademark or Patent Process is not completed, the status of the Artifact is changed to a word which means Abated Vital Being, and these can cause cyclical deterministic influence that affects individuals and those with whom they are associated, therefore one should request removal of the information or obtain assistance removing such information from such systems, while also demanding removal from the numerous websites which simply copy and republish such information to amplify the cyclically deterministic effect. If incurring a detrimental physiological, behavioral, or social outcome, and such outcome is included in information systems, then change addresses, phone numbers, names, and locations, thereby disrupting how detrimental outcomes, and multiple detrimental outcomes statistically, cyclically and deterministically potentiate detrimental outcomes. These recommendations for changes in information systems can disrupt patterns of Sudden Adverse Health Events, Sudden Adverse Behavior, Adverse Behavior, and Accidents. These factors are particularly applicable to Humans whom perform services for Systems of Civilization, Systems or Organizations otherwise or Humans Generally. Request that internet search engines and Geographical information systems remove aerial, terrestrial, photographic and precise locational information for Homes, Dwellings, and Buildings, particularly those of Vulnerable Populations including those associated with Humans performing activity for Systems of Civilization, those affected more prominently by systems of civilization, those exhibiting health or behavioral conditions, and Humanity generally. Change radio and televisions to channels or frequencies or amplitudes which are empty when not in use. Implement Area EMF Protection Devices or Material around the perimeter of buildings and Dwellings, including above buildings and Dwellings, along the perimeter of Neighborhoods, areas where detrimental outcomes occur more prominently such as addiction, compulsion, behavior, physiological outcomes, and accidents. Assure that programs are in place to always enable stable, safe and reliable access to Food, Housing, Health Services, Transportation, and financial means to participate in civilization systems, with a focus on satisfying the pathways which include Choline, Folate, S-Methylmethionine, Thetin, Glycine, Ethanolamine, CTP-Ethanolamine, CDP-Ethanolamine, Phosphatidylethanolamine, Phosphatidylethanolamine Methyltransferase, Phosphatidylmonomethylethanolamine, Phosphatidyldimethylethanolamine, DHA-Enriched Phosphatidylcholine, Lysophosphatidylcholine, Lysophosphatidylcholine acyltransferase, Homocysteine Depletion, Thetin-Homocysteine Methyltransferase, Methylthioglycolic Acid, Thioglycolic Acid and its derivatives, B-Lactams along with other Lactams and their derivatives, Thiazolidinones and Trimethylglycine, Glutathione, Reduced Glutathione, Glutathione Peroxidase, Superoxide Dismutase, Catalase, Tetrahydrobiopterin, L-arginine, Vanadium, B6, B12, Zinc, Calcium, Magnesium, Iron, 5,6,7,8Tetrahydrofolate, Riboflavin, Methyltetrahydrofolate, S-Adenosyl Methionine, Cysteine, Histidine, Aspartic Acid, Managed Trimethylamine-N-Oxide, NAD+/Niacin to reverse Hyperproliferation/Parthanotos duplicity along with Pentose Phosphate Pathway Inhibition at the same location as P53 which presents a most pivotal nuance of all pathology, MethylSulfonylmethane for Skeletal Structural Health (Prebiotic, Probiotic, Diverse Coverage Antibiotic, Balsamic Vinegar, Fruity Olive Oil, Grapeseed Oil, DMB), Managed Inducible Nitric Oxide Synthase(curcumin), Managed Uncoupled Nitric Oxide Synthase, Managed C-Reactive Protein, Managed Oxalate, Managed L - Lactic Acid including L - Lactate, Managed D - Lactic Acid including D – Lactate, Managed Methyl Glyoxal. Diverse Polyphenols, Tannins, Berberine, Curcumin, Favopiravir, HPMPC, and pathogen specific DNA Polymerase Inhibitors as well as RNA Polymerase inhibitors along CRISPR Gene Editing with any Viral or Microbial Condition. Crispr Cas 9, Choline Supplementation, Thetins, Mercaptans in inhibition of AP1, SP1, Thrombin, Trimethylamine-N-Oxide or inhibition any factors which inhibit PEMT, for any Genetic Condition or condition in which cellular entities proliferate atypically, differentiate atypically or exhibit changes to longevity. Each such factor, when managed, should be communicated to the individuals being assisted by such mitigation along with exhibition of the diagram regarding incipient favor, Reason and transformation by systems of such incipient statuses in contexts of reason into outcomes observed among Humanity, such that gradual regression of detrimental factors occurs along with awareness of such influences.