Rabbit Anti-RAB11FIP4 Antibody-SL21127R

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SunLong Biotech Co.,LTD Tel: 0086-571- 56623320 Fax:0086-571- 56623318 E-mail:[email protected] www.sunlongbiotech.com Rabbit Anti-RAB11FIP4 antibody SL21127R Product Name: RAB11FIP4 Chinese Name: G蛋白Binding proteinRAB相互作用蛋白4抗体 Rab11 family interacting protein 4; RAB11 FIP4; Rab11 FIP4 like; RGD1305063; Alias: RP23-271B20.4. Organism Species: Rabbit Clonality: Polyclonal React Species: Human,Mouse,Rat,Dog,Horse,Rabbit, ELISA=1:500-1000IHC-P=1:400-800IHC-F=1:400-800ICC=1:100-500IF=1:100- 500（Paraffin sections need antigen repair） Applications: not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. Molecular weight: 72kDa Cellular localization: cytoplasmic Form: Lyophilized or Liquid Concentration: 1mg/ml immunogen: KLH conjugated synthetic peptide derived from human RAB11FIP4:431-530/637 Lsotype: IgGwww.sunlongbiotech.com Purification: affinity purified by Protein A Storage Buffer: Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year Storage: when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed: PubMed Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP4 is one of many proteins that interact with and regulate Rab GTPases Product Detail: (Hales et al., 2001 [PubMed 11495908]).[supplied by OMIM, Apr 2008] Function: Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6. Subunit: Homodimer. Forms a complex with Rab11 (RAB11A or RAB11B) and ARF6. Interacts with RAB11A; the interaction is direct. Forms a heterooligomeric complex with RAB11FIP2, RAB11FIP3 and RAB11FIP5. Interacts with HCMV (human cytomegalovirus) gM/UL100. Interacts with ECM29. Tissue Specificity: Recycling endosome membrane; Peripheral membrane protein. Note: Colocalizes with RAB11A in the endocytic recycling compartment (ERC). SWISS: Q86YS3 Gene ID: 84440 Database links: Entrez Gene: 84440 Human Entrez Gene: 268451 Mouse Omim: 611999 Human SwissProt: Q86YS3 Human SwissProt: Q8BQP8 Mouse www.sunlongbiotech.com Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. .

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Figure 2S 4 7 A - C 080125 CSCs 080418 CSCs - + IFN-a 48 h + IFN-a 48 h + IFN-a 72 h 6 + IFN-a 72 h 3 5 MRFI 4 2 3 2 1 1 0 0 MHC I MHC II MICA MICB ULBP-1 ULBP-2 ULBP-3 ULBP-4 MHC I MHC II MICA MICB ULBP-1 ULBP-2 ULBP-3 ULBP-4 7 B 13 080125 FBS - D 080418 FBS - + IFN-a 48 h 12 + IFN-a 48 h + IFN-a 72 h + IFN-a 72 h 6 080125 FBS 11 10 5 9 8 4 7 6 3 MRFI 5 4 2 3 2 1 1 0 0 MHC I MHC II MICA MICB ULBP-1 ULBP-2 ULBP-3 ULBP-4 MHC I MHC II MICA MICB ULBP-1 ULBP-2 ULBP-3 ULBP-4 Molecule Molecule FIGURE 4S FIGURE 5S Panel A Panel B FIGURE 6S A B C D Supplemental Results Table 1S. Modulation by IFN-α of APM in GBM CSC and FBS tumor cell lines. Molecule * Cell line IFN-α‡ HLA β2-m# HLA LMP TAP1 TAP2 class II A A HC§ 2 7 10 080125 CSCs - 1∞ (1) 3 (65) 2 (91) 1 (2) 6 (47) 2 (61) 1 (3) 1 (2) 1 (3) + 2 (81) 11 (80) 13 (99) 1 (3) 8 (88) 4 (91) 1 (2) 1 (3) 2 (68) 080125 FBS - 2 (81) 4 (63) 4 (83) 1 (3) 6 (80) 3 (67) 2 (86) 1 (3) 2 (75) + 2 (99) 14 (90) 7 (97) 5 (75) 7 (100) 6 (98) 2 (90) 1 (4) 3 (87) 080418 CSCs - 2 (51) 1 (1) 1 (3) 2 (47) 2 (83) 2 (54) 1 (4) 1 (2) 1 (3) + 2 (81) 3 (76) 5 (75) 2 (50) 2 (83) 3 (71) 1 (3) 2 (87) 1 (2) 080418 FBS - 1 (3) 3 (70) 2 (88) 1 (4) 3 (87) 2 (76) 1 (3) 1 (3) 1 (2) + 2 (78) 7 (98) 5 (99) 2 (94) 5 (100) 3 (100) 1 (4) 2 (100) 1 (2) 070104 CSCs - 1 (2) 1 (3) 1 (3) 2 (78) 1 (3) 1 (2) 1 (3) 1 (3) 1 (2) + 2 (98) 8 (100) 10 (88) 4 (89) 3 (98) 3 (94) 1 (4) 2 (86) 2 (79) * expression of APM molecules was evaluated by intracellular staining and cytofluorimetric analysis; ‡ cells were treatead or not (+/-) for 72 h with 1000 IU/ml of IFN-α; # β-2 microglobulin; § β-2 microglobulin-free HLA-A heavy chain; ∞ values are indicated as ratio between the mean of fluorescence intensity of cells stained with the selected mAb and that of the negative control; bold values indicate significant MRFI (≥ 2).
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Genes Uniquely Expressed in Human Growth Plate Chondrocytes Uncover
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RAB11-Mediated Trafficking and Human Cancers: an Updated Review
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Hearing function and thresholds: a genome-wide association study in European isolated populations identifies new loci and pathways Giorgia Girotto, Nicola Pirastu, Rossella Sorice, Ginevra Biino, Harry Campbell, Adamo P. d’Adamo, Nicholas D. Hastie, Teresa Nutile, Ozren Polasek, Laura Portas, et al. To cite this version: Giorgia Girotto, Nicola Pirastu, Rossella Sorice, Ginevra Biino, Harry Campbell, et al.. Hearing function and thresholds: a genome-wide association study in European isolated populations identifies new loci and pathways. Journal of Medical Genetics, BMJ Publishing Group, 2011, 48 (6), pp.369. 10.1136/jmg.2010.088310. hal-00623287 HAL Id: hal-00623287 https://hal.archives-ouvertes.fr/hal-00623287 Submitted on 14 Sep 2011 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Hearing function and thresholds: a genome-wide association study in European isolated populations identifies new loci and pathways Giorgia Girotto1*, Nicola Pirastu1*, Rossella Sorice2, Ginevra Biino3,7, Harry Campbell6, Adamo P. d’Adamo1, Nicholas D. Hastie4, Teresa
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Gene-Gene Interaction Mapping of Human Cytomegalic Virus Through System Biology Approach
tems: ys Op l S e a n A ic c g Vijaylaxmi Saxena et al., Biol syst Open Access c o l e s o i s 2015, 4:2 B Biological Systems: Open Access DOI: 10.4172/2329-6577.1000141 ISSN: 2329-6577 Research Article Open Access Gene-Gene Interaction Mapping Of Human Cytomegalic Virus through System Biology Approach Vijaylaxmi Saxena, Supriya Dixit* and Alfisha Ashraf Coordinator, Bioinformatics Infrastructure Facility, Centre of DBT (Govt. of India), D.G. (P.G.) College, Kanpur (U.P), India *Corresponding author: Supriya Dixit, Bioinformatics Infrastructure Facility, Centre of DBT (Govt. India), Dayanand Girl’s P.G. College, Kanpur (U.P), India, Tel: 09415125252, E-mail: [email protected] Received date: Jul 14, 2015; Accepted date: Aug 28, 2015; Published date: Sep 05, 2015 Copyright: © 2015 Vijaylaxmi Saxena et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abstract Systems biology is concerned with the study of biological systems, by investigating the components of cellular networks and their interactions. The objective of present study is to build gene-gene interaction network of human cytomegalovirus genes with human genes and other influenza causing genes which helps to identify pathways, recognize gene function and find potential drug targets for cytomegalovirus visualized through cytoscape and its plugin. So, genetic interaction is logical interaction between two genes and more than that affects any organism phenotypically. Human cytomegalovirus has many strategies to survive the attack of the host.
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Supporting Information
Supporting Information Barrett et al. 10.1073/pnas.1508057112 SI Methods and Materials Stage four: Calculation of isoform expression levels. We used the eXpress Primary RNA-seq Data. The primary data for our study consisted of software package (55) to estimate isoform expression levels. The the RNA-seq data generated by TCGA (cancergenome.nih.gov) eXpress software requires two input files: a fasta file with mRNA for high-grade ovarian serous cystadenocarcinoma (OV) and by isoform nucleotide sequences and a BAM file with paired end read the GTEx project (11) for 43 different, nondiseased normal alignments in transcriptome (i.e., isoform-specific) coordinates. tissues. TCGA has generated RNA-seq datasets for 420 OV Because read alignments generated in stage three were in genomic samples, but many of them have been redacted or are from coordinates, we downloaded and custom modified the UBU replicate aliquots. We used table 1 from the October 10, 2013 software (https://github.com/mozack/ubu) to convert the genomic GDAC Summary Report (gdac.broadinstitute.org/runs/stddata__ alignment coordinates of each filtered read pair from stage three 2013_10_10/samples_report/OV.html) to identify the nonredacted to isoform coordinates for each isoform to which the read pair was samples and the best single sample from replicate aliquots. This found to be base pair-level consistent. We generated the input curation resulted in 296 samples, for which we then downloaded fasta file by including only nucleotide sequences for those isoforms the raw RNA-seq paired-end read data for our study. We used constituting the parsimonious set from stage three.
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