DOCSLIB.ORG

Farmaatsia- Terminoloogia Teine, Täiendatud Trükk

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Farmaatsia- Terminoloogia Teine, Täiendatud Trükk Farmaatsia- terminoloogia Teine, täiendatud trükk Graanulid Suspensioon Lahus Emulsioon Pillid Pulber Salv Kreem Aerosool Plaaster Sprei Pastill Tampoon Oblaat Emulsioon Kontsentraat Silmageel Tablett Haavapulk Ninatilgad Kapsel Lakukivi Inhalaator Farmaatsia- terminoloogia Teine, täiendatud trükk Tartu 2019 Koostajad: Toivo Hinrikus, Karin Kogermann, Ott Laius, Signe Leito, Ain Raal, Andres Soosaar, Triin Teppor, Daisy Volmer Keeletoimetaja: Tiina Kuusk Kirjastanud: Ravimiamet Nooruse 1, 50411 Tartu Telefon: +372 737 4140 Faks: +372 737 4142 E-post: [email protected] Esimene trükk 2010 Teine, täiendatud trükk 2019 Raamat on leitav Ravimiameti veebilehelt: www.ravimiamet.ee/farmaatsiaterminoloogia Väljaande refereerimisel või tsiteerimisel palume viidata allikale. ISBN 978-9949-9697-3-9 Sisukord Farmaatsiaterminoloogia Eestis..........................................................................................5 Üldised farmaatsiaalased terminid ...................................................................................10 Euroopa farmakopöa ......................................................................................................... 21 Euroopa farmakopöa sõnastik ..........................................................................................24 Standardterminid ..............................................................................................................29 Ravimvormid .....................................................................................................................29 Aurikulaarsed ravimvormid .......................................................................................30 Dentaalsed ravimvormid ...........................................................................................32 Endotservikaalsed ravimvormid ................................................................................34 Gastraalsed ravimvormid ..........................................................................................34 Gastrointestinaalsed ravimvormid ............................................................................34 Intestinaalsed ravimvormid .......................................................................................35 Intramammaarsed ravimvormid ................................................................................35 Intraperitoneaalsed ravimvormid ..............................................................................36 Intrauteriinsed ravimvormid ......................................................................................36 Intravesikaalsed/uretraalsed ravimvormid ................................................................ 37 Kehavälised ravimvormid ..........................................................................................39 Keskkonnakaudsed ravimvormid ..............................................................................40 Kutaansed/transdermaalsed ravimvormid ................................................................42 Muud ravimvormid .................................................................................................... 51 Nasaalsed ravimvormid ............................................................................................54 Okulaarsed ravimvormid ........................................................................................... 57 Okulonasaalsed ravimvormid ....................................................................................60 Oromukosaalsed ravimvormid ..................................................................................60 Parenteraalsed ravimvormid .....................................................................................65 Pulmonaalsed ravimvormid ......................................................................................73 Rektaalsed ravimvormid ........................................................................................... 77 Suukaudsed ravimvormid..........................................................................................80 Vaginaalsed ravimvormid ..........................................................................................94 Kombineeritud ravimvormid ..............................................................................................96 Kombineeritud terminid ...................................................................................................103 Manustamisviisid ............................................................................................................ 111 Pakendid..........................................................................................................................118 Droogid ............................................................................................................................127 Droogidega seotud mõisted ............................................................................................ 137 Toimeained ...................................................................................................................... 141 ATC-süsteemid.................................................................................................................195 Humaan-ATC süsteem .............................................................................................195 Veterinaar-ATC süsteem (ATCvet) ...........................................................................256 Farmaatsiaterminite lühendid ......................................................................................... 267 Kirjandus .........................................................................................................................280 Register ...........................................................................................................................283 Inglisekeelne ...........................................................................................................283 Eestikeelne .............................................................................................................. 301 FARMAATSIATERMINOLOOGIA EESTIS Farmaatsiaterminoloogia Eestis Farmaatsiaterminoloogia komisjonil on hea meel, et saame ametlikul eesti keele aastal, mis tähistab eesti keele mainimist riigikeelena sajand tagasi, ning komisjoni kahekümnendal tegutsemisaastal tuua lugejateni uue täiendatud farmaatsiaterminoloogia raamatu. Erinevatel perioodidel on mõistet „terminoloogia” tõlgendatud erinevalt. Teatmeteostes on kõige tavalisemaks definitsiooniks: < krterminus ’piir, raja’, < kr logos ’mõiste, õpetus’, 1) mingi eriala oskussõnavara, oskuskeele (erialakeele) terminite süsteem; 2) õpetus oskuskeelest, eriti terminitest ja neile esitatavatest nõuetest. Eesti üks juhtivaid terminolooge Tiiu Erelt alustab oma raamatut „Terminiõpetus” eesti oskuskeeleõpetuse käsitlusega, mis avab terminoloogia tähendused. Selle järgi on põhi- mõttelise ja praktilise tähtsusega eristada terminoloogiat ontoloogilises ja gnoseoloogilises tähenduses. Seejuures ontoloogilises ehk esemelises tähenduses mõistetakse terminoloogia all eelkõige mingil erialal või ka kõigil mis tahes erialadel kokku tarvitatavate oskussõnade hulka. Gnoseoloogilises ehk tunnetuslikus mõttes on terminoloogia eelkõige õpetus oskus- sõnadest, nende tuletamisest, korraldamisest ja tarvitamisest. Raamatus „Terminiõpetus” on põhjalikult lahti seletatud mõiste „terminoloogia” sidemed erinevate valdkondadega. Ühe mõttena tuuakse välja, et terminoloogia on piiriteadus – see, mille kohta tavatsetakse öelda „interdistsiplinaarne valdkond”. Seejuures kõige tihedamad on sidemed keeleteadusega. Ter- minoloogia on nii ontoloogilises kui ka gnoseoloogilises tähenduses seotud mitmesuguste erialade, eriti teadusaladega. See on integreeritud iga teadusala süsteemi, saades sealt samal ajal oma materjali. Farmaatsiaterminoloogia on tihedalt seotud meditsiiniterminoloogiaga. Kohati on nende eristamine üsnagi küsitav. Vahest kõige enam seostub farmaatsiaterminoloogia selliste mõistetega nagu „ravimtaim”, „raviaine”, „ravim”, „ravimvorm”, sh nende omaduste, valmis- tamise (sünteesimise), analüüsimise, säilitamise, pakendamise ja väljastamisega. Seega kõige sellega, mis on seotud ravimi valmimisega, kõrvale ei saa jätta ka kohta, kus selline tegevus toimub (nt apteek). Ravimite manustamisviisi määrab arst, kuid õpetussõnad selle kasutamise kohta annab kaasa ka apteeker. Farmaatsiaterminoloogia kujunemine ja areng on seotud erinevate farmaatsiavaldkondade arenguga, samuti terminite praktilise kasutamisega. Üheks vanimaks farmaatsiaharuks on kindlasti farmakognoosia – õpetus ravimtaimedest. Jüri kihelkonna pastori Anton Thor Helle keelelises käsiraamatus „Kurzgefaszte Anweisung zur Ehstnischen Sprache”, mis trükiti 1732. a ja mis on eesti kultuuriloos vägagi tuntud väljaanne, on muu kõrval toodud eesti-saksa-ladina sõnastik ravimtaimede ja droogide nimetustega. Seda väljaannet võib vaadelda kui üht esimest farmaatsiaterminoloogiat sisaldavat käsiraamatut. Raamatus toodust on senini kasutusel nt angerpist (anger=pistid), harakalatv (harraka ladwad), koerapöörirohi (koera pöri rohhi, hullo koera rohhud), hundinui (hunti kurrikad), käoking (käo kingad), kanarbik (kannarpik), karikakar (karri kakrad), karu- putk (karro putk), kassikäpp (kassi käppikesed), kirburohi (kirpo rohhi), koeraputk (koerputk), koirohi (koirohhi), maarjahein (maarjaheinad, maarja rohhud), magun (maggunad), nurmenukk (nurme nukkud), paiseleht (paiso lehhed), piibeleht (pibe lehhed), raudrohi (raud rohhi), sinilill 5 FARMAATSIATERMINOLOOGIA EESTIS
Load more

Recommended publications
  • Medical Review(S) Clinical Review
    CENTER FOR DRUG EVALUATION AND RESEARCH APPLICATION NUMBER: 200327 MEDICAL REVIEW(S) CLINICAL REVIEW Application Type NDA Application Number(s) 200327 Priority or Standard Standard Submit Date(s) December 29, 2009 Received Date(s) December 30, 2009 PDUFA Goal Date October 30, 2010 Division / Office Division of Anti-Infective and Ophthalmology Products Office of Antimicrobial Products Reviewer Name(s) Ariel Ramirez Porcalla, MD, MPH Neil Rellosa, MD Review Completion October 29, 2010 Date Established Name Ceftaroline fosamil for injection (Proposed) Trade Name Teflaro Therapeutic Class Cephalosporin; ß-lactams Applicant Cerexa, Inc. Forest Laboratories, Inc. Formulation(s) 400 mg/vial and 600 mg/vial Intravenous Dosing Regimen 600 mg every 12 hours by IV infusion Indication(s) Acute Bacterial Skin and Skin Structure Infection (ABSSSI); Community-acquired Bacterial Pneumonia (CABP) Intended Population(s) Adults ≥ 18 years of age Template Version: March 6, 2009 Reference ID: 2857265 Clinical Review Ariel Ramirez Porcalla, MD, MPH Neil Rellosa, MD NDA 200327: Teflaro (ceftaroline fosamil) Table of Contents 1 RECOMMENDATIONS/RISK BENEFIT ASSESSMENT ......................................... 9 1.1 Recommendation on Regulatory Action ........................................................... 10 1.2 Risk Benefit Assessment.................................................................................. 10 1.3 Recommendations for Postmarketing Risk Evaluation and Mitigation Strategies ........................................................................................................................
    [Show full text]
  • Nitrate Prodrugs Able to Release Nitric Oxide in a Controlled and Selective
    Europäisches Patentamt *EP001336602A1* (19) European Patent Office Office européen des brevets (11) EP 1 336 602 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.7: C07C 205/00, A61K 31/00 20.08.2003 Bulletin 2003/34 (21) Application number: 02425075.5 (22) Date of filing: 13.02.2002 (84) Designated Contracting States: (71) Applicant: Scaramuzzino, Giovanni AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU 20052 Monza (Milano) (IT) MC NL PT SE TR Designated Extension States: (72) Inventor: Scaramuzzino, Giovanni AL LT LV MK RO SI 20052 Monza (Milano) (IT) (54) Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases (57) New pharmaceutical compounds of general effects and for this reason they are useful for the prep- formula (I): F-(X)q where q is an integer from 1 to 5, pref- aration of medicines for prevention and treatment of in- erably 1; -F is chosen among drugs described in the text, flammatory, ischemic, degenerative and proliferative -X is chosen among 4 groups -M, -T, -V and -Y as de- diseases of musculoskeletal, tegumental, respiratory, scribed in the text. gastrointestinal, genito-urinary and central nervous sys- The compounds of general formula (I) are nitrate tems. prodrugs which can release nitric oxide in vivo in a con- trolled and selective way and without hypotensive side EP 1 336 602 A1 Printed by Jouve, 75001 PARIS (FR) EP 1 336 602 A1 Description [0001] The present invention relates to new nitrate prodrugs which can release nitric oxide in vivo in a controlled and selective way and without the side effects typical of nitrate vasodilators drugs.
    [Show full text]
  • The National Drugs List
    ^ ^ ^ ^ ^[ ^ The National Drugs List Of Syrian Arab Republic Sexth Edition 2006 ! " # "$ % &'() " # * +$, -. / & 0 /+12 3 4" 5 "$ . "$ 67"5,) 0 " /! !2 4? @ % 88 9 3: " # "$ ;+<=2 – G# H H2 I) – 6( – 65 : A B C "5 : , D )* . J!* HK"3 H"$ T ) 4 B K<) +$ LMA N O 3 4P<B &Q / RS ) H< C4VH /430 / 1988 V W* < C A GQ ") 4V / 1000 / C4VH /820 / 2001 V XX K<# C ,V /500 / 1992 V "!X V /946 / 2004 V Z < C V /914 / 2003 V ) < ] +$, [2 / ,) @# @ S%Q2 J"= [ &<\ @ +$ LMA 1 O \ . S X '( ^ & M_ `AB @ &' 3 4" + @ V= 4 )\ " : N " # "$ 6 ) G" 3Q + a C G /<"B d3: C K7 e , fM 4 Q b"$ " < $\ c"7: 5) G . HHH3Q J # Hg ' V"h 6< G* H5 !" # $%" & $' ,* ( )* + 2 ا اوا ادو +% 5 j 2 i1 6 B J' 6<X " 6"[ i2 "$ "< * i3 10 6 i4 11 6! ^ i5 13 6<X "!# * i6 15 7 G!, 6 - k 24"$d dl ?K V *4V h 63[46 ' i8 19 Adl 20 "( 2 i9 20 G Q) 6 i10 20 a 6 m[, 6 i11 21 ?K V $n i12 21 "% * i13 23 b+ 6 i14 23 oe C * i15 24 !, 2 6\ i16 25 C V pq * i17 26 ( S 6) 1, ++ &"r i19 3 +% 27 G 6 ""% i19 28 ^ Ks 2 i20 31 % Ks 2 i21 32 s * i22 35 " " * i23 37 "$ * i24 38 6" i25 39 V t h Gu* v!* 2 i26 39 ( 2 i27 40 B w< Ks 2 i28 40 d C &"r i29 42 "' 6 i30 42 " * i31 42 ":< * i32 5 ./ 0" -33 4 : ANAESTHETICS $ 1 2 -1 :GENERAL ANAESTHETICS AND OXYGEN 4 $1 2 2- ATRACURIUM BESYLATE DROPERIDOL ETHER FENTANYL HALOTHANE ISOFLURANE KETAMINE HCL NITROUS OXIDE OXYGEN PROPOFOL REMIFENTANIL SEVOFLURANE SUFENTANIL THIOPENTAL :LOCAL ANAESTHETICS !67$1 2 -5 AMYLEINE HCL=AMYLOCAINE ARTICAINE BENZOCAINE BUPIVACAINE CINCHOCAINE LIDOCAINE MEPIVACAINE OXETHAZAINE PRAMOXINE PRILOCAINE PREOPERATIVE MEDICATION & SEDATION FOR 9*: ;< " 2 -8 : : SHORT -TERM PROCEDURES ATROPINE DIAZEPAM INJ.
    [Show full text]
  • 18 December 2020 – to Date)
    (18 December 2020 – to date) MEDICINES AND RELATED SUBSTANCES ACT 101 OF 1965 (Gazette No. 1171, Notice No. 1002 dated 7 July 1965. Commencement date: 1 April 1966 [Proc. No. 94, Gazette No. 1413] SCHEDULES Government Notice 935 in Government Gazette 31387 dated 5 September 2008. Commencement date: 5 September 2008. As amended by: Government Notice R1230 in Government Gazette 32838 dated 31 December 2009. Commencement date: 31 December 2009. Government Notice R227 in Government Gazette 35149 dated 15 March 2012. Commencement date: 15 March 2012. Government Notice R674 in Government Gazette 36827 dated 13 September 2013. Commencement date: 13 September 2013. Government Notice R690 in Government Gazette 36850 dated 20 September 2013. Commencement date: 20 September 2013. Government Notice R104 in Government Gazette 37318 dated 11 February 2014. Commencement date: 11 February 2014. Government Notice R352 in Government Gazette 37622 dated 8 May 2014. Commencement date: 8 May 2014. Government Notice R234 in Government Gazette 38586 dated 20 March 2015. Commencement date: 20 March 2015. Government Notice 254 in Government Gazette 39815 dated 15 March 2016. Commencement date: 15 March 2016. Government Notice 620 in Government Gazette 40041 dated 3 June 2016. Commencement date: 3 June 2016. Prepared by: Page 2 of 199 Government Notice 748 in Government Gazette 41009 dated 28 July 2017. Commencement date: 28 July 2017. Government Notice 1261 in Government Gazette 41256 dated 17 November 2017. Commencement date: 17 November 2017. Government Notice R1098 in Government Gazette 41971 dated 12 October 2018. Commencement date: 12 October 2018. Government Notice R1262 in Government Gazette 42052 dated 23 November 2018.
    [Show full text]
  • Classification of Medicinal Drugs and Driving: Co-Ordination and Synthesis Report
    Project No. TREN-05-FP6TR-S07.61320-518404-DRUID DRUID Driving under the Influence of Drugs, Alcohol and Medicines Integrated Project 1.6. Sustainable Development, Global Change and Ecosystem 1.6.2: Sustainable Surface Transport 6th Framework Programme Deliverable 4.4.1 Classification of medicinal drugs and driving: Co-ordination and synthesis report. Due date of deliverable: 21.07.2011 Actual submission date: 21.07.2011 Revision date: 21.07.2011 Start date of project: 15.10.2006 Duration: 48 months Organisation name of lead contractor for this deliverable: UVA Revision 0.0 Project co-funded by the European Commission within the Sixth Framework Programme (2002-2006) Dissemination Level PU Public PP Restricted to other programme participants (including the Commission x Services) RE Restricted to a group specified by the consortium (including the Commission Services) CO Confidential, only for members of the consortium (including the Commission Services) DRUID 6th Framework Programme Deliverable D.4.4.1 Classification of medicinal drugs and driving: Co-ordination and synthesis report. Page 1 of 243 Classification of medicinal drugs and driving: Co-ordination and synthesis report. Authors Trinidad Gómez-Talegón, Inmaculada Fierro, M. Carmen Del Río, F. Javier Álvarez (UVa, University of Valladolid, Spain) Partners - Silvia Ravera, Susana Monteiro, Han de Gier (RUGPha, University of Groningen, the Netherlands) - Gertrude Van der Linden, Sara-Ann Legrand, Kristof Pil, Alain Verstraete (UGent, Ghent University, Belgium) - Michel Mallaret, Charles Mercier-Guyon, Isabelle Mercier-Guyon (UGren, University of Grenoble, Centre Regional de Pharmacovigilance, France) - Katerina Touliou (CERT-HIT, Centre for Research and Technology Hellas, Greece) - Michael Hei βing (BASt, Bundesanstalt für Straßenwesen, Germany).
    [Show full text]
  • Protocol Supplementary
    Optimal Pharmacological Management and Prevention of Glucocorticoid-Induced Osteoporosis (GIOP) Protocol for a Systematic Review and Network Meta-Analysis Supplementary Materials: Sample Search Strategy Supplementary 1: MEDLINE Search Strategy Database: OVID Medline Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R) 1946 to Present Line 1 exp Osteoporosis/ 2 osteoporos?s.ti,ab,kf. 3 Bone Diseases, Metabolic/ 4 osteop?eni*.ti,ab,kf. 5 Bone Diseases/ 6 exp Bone Resorption/ 7 malabsorption.ti,ab,kf. 8 Bone Density/ 9 BMD.ti,ab,kf. 10 exp Fractures, Bone/ 11 fracture*.ti,ab,kf. 12 (bone* adj2 (loss* or disease* or resorption* or densit* or content* or fragil* or mass* or demineral* or decalcif* or calcif* or strength*)).ti,ab,kf. 13 osteomalacia.ti,ab,kf. 14 or/1-13 15 exp Glucocorticoids/ 16 exp Steroids/ 17 (glucocorticoid* or steroid* or prednisone or prednisolone or hydrocortisone or cortisone or triamcinolone or dexamethasone or betamethasone or methylprednisolone).ti,ab,kf. 18 or/15-17 19 14 and 18 20 ((glucocorticoid-induced or glucosteroid-induced or corticosteroid-induced or glucocorticosteroid-induced) adj1 osteoporos?s).ti,ab,kf. 21 19 or 20 22 exp Diphosphonates/ 23 (bisphosphon* or diphosphon*).ti,ab,kf. 24 exp organophosphates/ or organophosphonates/ 25 (organophosphate* or organophosphonate*).ti,ab,kf. 26 (alendronate or alendronic acid or Fosamax or Binosto or Denfos or Fosagen or Lendrate).ti,ab,kf. 27 (Densidron or Adrovance or Alenotop or Alned or Dronat or Durost or Fixopan or Forosa or Fosval or Huesobone or Ostemax or Oseolen or Arendal or Beenos or Berlex or Fosalen or Fosmin or Fostolin or Fosavance).ti,ab,kf.
    [Show full text]
  • Abuse-Proof Solid Pharmaceutical Composition
    (19) TZZ¥¥ ¥_T (11) EP 3 329 939 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.: 06.06.2018 Bulletin 2018/23 A61K 47/02 (2006.01) A61K 47/36 (2006.01) A61K 9/16 (2006.01) A61K 31/485 (2006.01) (2006.01) (21) Application number: 17204525.4 A61K 31/192 (22) Date of filing: 29.11.2017 (84) Designated Contracting States: (72) Inventors: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB • BOSCHETTI, Silvia GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO I-38060 Aldeno (TN) (IT) PL PT RO RS SE SI SK SM TR • ROSSI, Massimiliano Designated Extension States: I-38121 Trento (IT) BA ME • BENFENATI, Diego Designated Validation States: I-38052 Caldonazzo (TN) (IT) MA MD • POJER, Alessandro I-38092 Altavalle (TN) (IT) (30) Priority: 02.12.2016 IT 201600122469 (74) Representative: Allaix, Roberto (71) Applicant: E-Pharma Trento S.p.A. PGA S.p.A. 38123 Trento (IT) Via Mascheroni, 31 20145 Milano (IT) (54) ABUSE-PROOF SOLID PHARMACEUTICAL COMPOSITION (57) The present invention relates to an abuse-proof solid pharmaceutical composition comprising an active ingre- dient with potential for abuse, silica in an amount of from 10 mg to 1000 mg, guar flour in an amount of from 100 mg to 300 mg, and a water soluble diluent in an amount of from 500 mg to 5000 mg. EP 3 329 939 A1 Printed by Jouve, 75001 PARIS (FR) EP 3 329 939 A1 Description FIELD OF THE INVENTION 5 [0001] The present invention relates to an abuse-proof solid pharmaceutical composition, in particular a solid phar- maceutical composition, such as, for example a granulate or a tablet, capable of solubilizing in a glass of water (about 100 ml), but of forming a not injectable gel and/or viscous solution if added to the amount of water contained in a hypodermic syringe (about 10 ml).
    [Show full text]
  • Tavalisse™ (Fostamatinib) (Oral) Document Number: IC-0361 Last Review Date: 02/02/2021 Date of Origin: 06/01/2018 Dates Reviewed: 06/2018, 02/2019, 02/2020, 02/2021
    Tavalisse™ (fostamatinib) (Oral) Document Number: IC-0361 Last Review Date: 02/02/2021 Date of Origin: 06/01/2018 Dates Reviewed: 06/2018, 02/2019, 02/2020, 02/2021 I. Length of Authorization Coverage is provided for six months and may be renewed. II. Dosing Limits A. Quantity Limit (max daily dose) [NDC Unit]: 100 mg tablets – 2 tablets per day 150 mg tablets – 2 tablets per day B. Max Units (per dose and over time) [HCPCS Unit]: 300 mg daily III. Initial Approval Criteria 1,2 Coverage is provided in the following conditions: Patient is at least 18 years of age; AND Universal Criteria 1 Patient is not receiving a thrombopoietin receptor agonist or mimetic (e.g., romiplostim, eltrombopag, lusutrombopag, avatrombopag, etc.); AND Laboratory values are current (i.e., drawn within the previous 28 days); AND Fostamatinib is not being used to attempt to normalize platelet count; AND Patient will avoid concomitant therapy with any of the following: o Coadministration with strong CYP3A4 inhibitors (e.g., clarithromycin, itraconazole, ketoconazole, etc.), or if therapy is unavoidable, the patient will be monitored closely for adverse reaction and/or dose modifications will be implemented; AND o Coadministration with strong CYP3A inducers (e.g., rifampin, carbamazepine, St. John’s Wort, etc.); AND Chronic Immune Thrombocytopenia (ITP) † 1-5 Patient has had persistent/chronic ITP for at least 3 months; AND Proprietary & Confidential © 2021 Magellan Health, Inc. Patient has previously failed any of the following treatments for ITP: Patient has failed previous therapy with corticosteroids (i.e., patient had no response to at least a 3-month trial or is corticosteroid-dependent); OR Patient has failed previous therapy with immunoglobulins; OR Patient has had a splenectomy; OR Patient has failed previous therapy with a thrombopoietin receptor agonist; AND The patient is at increased risk for bleeding as indicated by platelet count of less than 30 × 109/L (30,000/mm³) † FDA Approved Indication(s) IV.
    [Show full text]
  • (19) United States (12) Patent Application Publication (10) Pub
    US 20130289061A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2013/0289061 A1 Bhide et al. (43) Pub. Date: Oct. 31, 2013 (54) METHODS AND COMPOSITIONS TO Publication Classi?cation PREVENT ADDICTION (51) Int. Cl. (71) Applicant: The General Hospital Corporation, A61K 31/485 (2006-01) Boston’ MA (Us) A61K 31/4458 (2006.01) (52) U.S. Cl. (72) Inventors: Pradeep G. Bhide; Peabody, MA (US); CPC """"" " A61K31/485 (201301); ‘4161223011? Jmm‘“ Zhu’ Ansm’ MA. (Us); USPC ......... .. 514/282; 514/317; 514/654; 514/618; Thomas J. Spencer; Carhsle; MA (US); 514/279 Joseph Biederman; Brookline; MA (Us) (57) ABSTRACT Disclosed herein is a method of reducing or preventing the development of aversion to a CNS stimulant in a subject (21) App1_ NO_; 13/924,815 comprising; administering a therapeutic amount of the neu rological stimulant and administering an antagonist of the kappa opioid receptor; to thereby reduce or prevent the devel - . opment of aversion to the CNS stimulant in the subject. Also (22) Flled' Jun‘ 24’ 2013 disclosed is a method of reducing or preventing the develop ment of addiction to a CNS stimulant in a subj ect; comprising; _ _ administering the CNS stimulant and administering a mu Related U‘s‘ Apphcatlon Data opioid receptor antagonist to thereby reduce or prevent the (63) Continuation of application NO 13/389,959, ?led on development of addiction to the CNS stimulant in the subject. Apt 27’ 2012’ ?led as application NO_ PCT/US2010/ Also disclosed are pharmaceutical compositions comprising 045486 on Aug' 13 2010' a central nervous system stimulant and an opioid receptor ’ antagonist.
    [Show full text]
  • Tiludronate 1105 Osteoporosis
    Strontium Ranelate/Tiludronate 1105 Osteoporosis. Strontium ranelate, given orally with calcium temic hypersensitivity reactions should be borne in mind. Hyper- Data on combination therapy are limited, but some studies sug- and vitamin D supplements, has been found to reduce the risk of calcaemia may develop with teriparatide or the acetate and it is gest that teriparatide with HRT is more effective than HRT vertebral1 and non-vertebral2 fractures in postmenopausal wom- therefore contra-indicated in patients with pre-existing hypercal- alone.9 The effect of teriparatide with the antiresorptive bisphos- en with osteoporosis. A pooled analysis of data from these 2 caemia. phonates has yet to be determined.2,6,9,10 Although there is some studies concluded that strontium ranelate reduced both vertebral suggestion that teriparatide still increases bone formation after 3 Teriparatide is contra-indicated in patients with severe renal im- 9 and non-vertebral fractures in patients aged 80 years or older. pairment and should be used with caution with those with mod- treatment with alendronate, a study in men found that, when Protection against fractures was detected within 12 months, and erate impairment. given together, alendronate impaired the anabolic effects of teri- sustained throughout 3 years of treatment. Hip fractures were paratide.11 For this reason, some consider that teriparatide be also reduced over 3 years, but this did not reach statistical signif- There have been reports of osteosarcoma in rats given teripara- started immediately after stopping bisphosphonates.10 It has been icance; the authors concluded that the analysis may not have tide and patients who may be at increased risk, including those suggested that the degree of suppression of bone turnover before been sufficiently powered in this respect.
    [Show full text]
  • Classification Decisions Taken by the Harmonized System Committee from the 47Th to 60Th Sessions (2011
    CLASSIFICATION DECISIONS TAKEN BY THE HARMONIZED SYSTEM COMMITTEE FROM THE 47TH TO 60TH SESSIONS (2011 - 2018) WORLD CUSTOMS ORGANIZATION Rue du Marché 30 B-1210 Brussels Belgium November 2011 Copyright © 2011 World Customs Organization. All rights reserved. Requests and inquiries concerning translation, reproduction and adaptation rights should be addressed to [email protected]. D/2011/0448/25 The following list contains the classification decisions (other than those subject to a reservation) taken by the Harmonized System Committee ( 47th Session – March 2011) on specific products, together with their related Harmonized System code numbers and, in certain cases, the classification rationale. Advice Parties seeking to import or export merchandise covered by a decision are advised to verify the implementation of the decision by the importing or exporting country, as the case may be. HS codes Classification No Product description Classification considered rationale 1. Preparation, in the form of a powder, consisting of 92 % sugar, 6 % 2106.90 GRIs 1 and 6 black currant powder, anticaking agent, citric acid and black currant flavouring, put up for retail sale in 32-gram sachets, intended to be consumed as a beverage after mixing with hot water. 2. Vanutide cridificar (INN List 100). 3002.20 3. Certain INN products. Chapters 28, 29 (See “INN List 101” at the end of this publication.) and 30 4. Certain INN products. Chapters 13, 29 (See “INN List 102” at the end of this publication.) and 30 5. Certain INN products. Chapters 28, 29, (See “INN List 103” at the end of this publication.) 30, 35 and 39 6. Re-classification of INN products.
    [Show full text]
  • Compositions and Methods for Selective Delivery of Oligonucleotide Molecules to Specific Neuron Types
    (19) TZZ ¥Z_T (11) EP 2 380 595 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.: 26.10.2011 Bulletin 2011/43 A61K 47/48 (2006.01) C12N 15/11 (2006.01) A61P 25/00 (2006.01) A61K 49/00 (2006.01) (2006.01) (21) Application number: 10382087.4 A61K 51/00 (22) Date of filing: 19.04.2010 (84) Designated Contracting States: • Alvarado Urbina, Gabriel AT BE BG CH CY CZ DE DK EE ES FI FR GB GR Nepean Ontario K2G 4Z1 (CA) HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL • Bortolozzi Biassoni, Analia Alejandra PT RO SE SI SK SM TR E-08036, Barcelona (ES) Designated Extension States: • Artigas Perez, Francesc AL BA ME RS E-08036, Barcelona (ES) • Vila Bover, Miquel (71) Applicant: Nlife Therapeutics S.L. 15006 La Coruna (ES) E-08035, Barcelona (ES) (72) Inventors: (74) Representative: ABG Patentes, S.L. • Montefeltro, Andrés Pablo Avenida de Burgos 16D E-08014, Barcelon (ES) Edificio Euromor 28036 Madrid (ES) (54) Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types (57) The invention provides a conjugate comprising nucleuc acid toi cell of interests and thus, for the treat- (i) a nucleic acid which is complementary to a target nu- ment of diseases which require a down-regulation of the cleic acid sequence and which expression prevents or protein encoded by the target nucleic acid as well as for reduces expression of the target nucleic acid and (ii) a the delivery of contrast agents to the cells for diagnostic selectivity agent which is capable of binding with high purposes.
    [Show full text]