plants Article Ingol and Ingenol-Type Diterpenes from Euphorbia trigona Miller with Keratinocyte Inhibitory Activity Reham Hammadi 1, Norbert Kúsz 1 , Csilla Zsuzsanna Dávid 1, Zoltán Behány 2,László Papp 3, Lajos Kemény 2 , Judit Hohmann 1,4,Lóránt Lakatos 2,5,* and Andrea Vasas 1,* 1 Department of Pharmacognosy, Interdisciplinary Excellence Centre, University of Szeged, Eötvös u. 6, 6720 Szeged, Hungary;
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[email protected] (N.K.);
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[email protected] (J.H.) 2 Department of Dermatology and Allergology, University of Szeged, Korányi fasor 6, 6720 Szeged, Hungary;
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[email protected] (L.K.) 3 Botanical Garden, Eötvös Loránd University, Illés u. 25, 1083 Budapest, Hungary;
[email protected] 4 Interdisciplinary Centre of Natural Products, University of Szeged, Eötvös u. 6, 6720 Szeged, Hungary 5 Photo- and Chronobiology Group Eötvös Loránd Research Network (ELKH), Institute of Plant Biology, Biological Research Center Szeged, Temesvári krt. 62, 6726 Szeged, Hungary * Correspondence:
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[email protected] (A.V.); Tel.: +36-62546451 (A.V.) Abstract: Ingenol mebutate, isolated from Euphorbia peplus, is an ingenane-type diterpenoid, primarily used for the topical treatment of actinic keratosis, a premalignant skin condition. The aim of our work was to investigate other Euphorbia species to find structurally similar diterpenes that can be used as alternatives to ingenol mebutate. Pharmacological investigation of Euphorbia candelabrum, Euphorbia Citation: Hammadi, R.; Kúsz, N.; cotinifolia, Euphorbia ramipressa, and Euphorbia trigona revealed the potent keratinocyte (HPV-Ker cell Dávid, C.Z.; Behány, Z.; Papp, L.; line) inhibitory activity of these spurge species.