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Colonoscopic Review and Surgical Approach in the Management of Colorectal Carcinoma–A Retrospective Study of 50 Cases

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Colonoscopic Review and Surgical Approach in the Management of Colorectal Carcinoma–A Retrospective Study of 50 Cases Original Paper Colonoscopic Review and Surgical Approach in the Management of Colorectal Carcinoma–A Retrospective Study of 50 cases 1 2 3 Ershad-ul-Quadir M , Rahman MMM , Rahman MM Abstract Introduction: There is no exact statistics about the with abdominal pain 12 out of 22 cases (56%) and incidence of colorectal cancer in Bangladesh. weight loss 15 cases (68%). For left colon cancer According to National Cancer Institute, London, it is commonest symptom was weight loss and weakness the 2nd most common cancer affecting more than and altered bowel habit. Almost all cases with rectal 30,000 people in each year. As many patients with carcinoma presented with bleeding per rectum. colon cancer do not develop symptoms until it is advanced and detection in early stage can only be Conclusion: About 50% of lesions were found in achieved by screening of asymptomatic person. recto-sigmoid junction and male: female ratio was Maximum patients present lately with distance 1.9:1. All efforts and modern technology should be metastases when there is nothing to treat except applied for early detection and treatment. The palliative therapy. survival rate is usually very poor in rectal carcinoma. In this study most of the cases were subjected to Objectives: To identify the risk factors, early post operative Chemo and Radiotherapy, but more symptoms, signs, treatment modalities, operative were treated with neoadjuvant chemoradiation for outcome, morbidity and mortality rate. down staging. The need for early detection of Colorectal Carcinoma (CRC) should be stressed in Materials and Methods: This retrospective study the form of screening patient awareness and was carried out at CMH Dhaka during August 2002 understanding about symptomatology. Early diagnosis to August 2004. A total of 50 patients were taken as and definitive treatment are thereby increasing study sample. All the patients were admitted in expectation of higher survival and better prognosis in different surgical units of CMH Dhaka for surgical patient of colorectal carcinoma. treatment. Detailed history were taken on admission by a questionnaire and examined thoroughly and Key-words: Colorectal Carcinoma, Palliative Therapy, findings regarding Anaemia, Jaundice, Dehydration, Serum Tumour Marker, Fecal Occult Blood Test (FOBT), Oedema, Lymphadenopathy, Nutritional status and Carcino Embryonic Antigen (CEA). abnormal signs like ascites, distension, rigidity, organomegaly recorded. Digital rectal examination Introduction were done in all cases and finally examined by There is no exact statistics about the incidence of Proctoscope, Sigmoidoscope and with Colonoscope. colonic cancer in Bangladesh. According to National FOBT (Fecal Occult Blood Test), serum tumour cancer Institute, London April 2001, it is the 2nd most marker was also assessed. common cancer affecting more than 30,000 people in each year. 80% of these cases are not diagnosed Results: Out of 50 cases 22 were rectal carcinoma until the cancer has spread the bowel or beyond. and next common site was caecum and number was Such cases have worse prognosis than carcinoma 10. There was a variation in the sex ratio. Out of 50 confined to bowel wall. As many patients with colon cases 33 were male and 17 were female. The cancer do not develops symptoms until the highest incidence was among people of 6th decade carcinoma is advanced. The early detection of (28%) and next highest was in 4th decade (24%). greater portion can only be achieved by the Majority of patient with right colon cancer presented screening of asymptomatic persons. 1. Lt Col Md Ershad-ul-Quadir, MBBS, FCPS, Classified Surgical Specialist, BNS Patenga, Navy Hospital 2. Maj Gen Munshi Md Mojibur Rahman, MBBS, MCPS, FICS, FCPS(Surgery), Consultant Surgeon General, Bangladesh Armed Forces, Ministry of Defence, Director General of Medical Services 3. Brig Gen Md Mahbubur Rahman, MBBS, FCPS (Surgery), Fellow Colorectal Surgery, Chief Surgeon, CMH, Dhaka. JAFMC Bangladesh. Vol 11, No 2 (December) 2015 36 Maximum patient present lately with distance Histopathological examinations were done for each metastases when there is nothing left to surgeon to case. Post operative period were followed up to note treat these unfortunate cancer victims except any morbidity and mortality. Patients were advised palliative therapy. to follow up for further chemotherapy and radiotherapy one month after operation or earlier in Screening and detection of the early presentation of case where there are any complications. carcinoma are the two important tools, used to reduce the cancer related morbidity and this study Results choiced the later one and selected those patients In this study the statistical data were collected from who are already diagnosed as Ca-colon to find out the detailed information of each case which have any clue related to earlier presentation. This study been presented in tabulated form. with limitation tried to identify the risk factors, early symptoms, signs, treatment modalities, operative Table-I: Sex and site involved (n= 50) outcome, morbidity, mortality rate and also tried to Sites Cases Cases Male Female M : F find out the suitable-investigations for these patients. Ratio This study is a tip of ice-burg of a vast subject and (n = 50) Caecum 10 (20%) 8 2 3:4:1 it recommends further study to draw a complete Ascending colon 8 (16%) 22 (44%) 7 1 conclusion. Right colic lexure 4 (8%) 2 2 Transverse colon 0 Left colic lexure 1 (2%) 1 2:1 6 (12%) Materials and Methods Descending colon 2 (4%) 1 1 This retrospective study of 50 cases of colorectal Sigmoid colon 3 (6%) 2 1 TReocttaolsigmoid junction 500 33 17 1:9:1 carcinoma carried out in different surgical units at Rectum 22 (44%) 22 (44%) 12 10 1:2:1 CMH Dhaka during the period from August 2002 to August 2004. For all cases, detailed history of the Table-I shows involvement of colorectal carcinoma patients on admission was taken by a questionnaire. in different sites and sexes. Out of 50 cases 22 were The cases were examined thoroughly and general rectal carcinoma. The next common site was findings regarding Anaemia, Jaundice, Dehydration, caecum and the number was 10. The relative Oedema, Lymphadenopathy, Nutritional status and incidence in the study was approximately 44% for abnormal signs- like ascites, distension, rigidity, rectum, 44% for Right colon and 12% for Left colon. organomegaly were recorded. Digital rectal Out of 50 cases 33 were male and 17 were female. examinations were done in all cases. Patients In all sites males are affected more than females. examined by proctoscope, sigmoidoscope and finally with colonoscope. Fecal Occult Blood Test Table-II: Incidence in different age groups (n =50) (FOBT) and serum tumour marker were also Age ( Years) Total (no) Rt side Lt side Rectum assessed. 10-20 3 (6%) 1 (2%) 1 (2%) 1 (2%) 21-30 9 (18%) 5 (10%) 0 4 (8%) Relevant routine investigations were done in all 31-40 12 (24%) 5 (10%) 4 (8%) 3 (6%) cases. X-Ray chest and double contrast barium 41-50 10 (20%) 6 (12%) 0 4 (8%) 51-60 14 (28%) 3 (6%) 1 (2%) 10 (20%) enema of large gut was done for all cases except 61-70 1 (2%) 1 (2%) 0 0 those with intestinal obstruction, perforation, also T71o-t8a0l 1 (520%) 31 (62%) 6 (102%) 22 (404%) refusal for painful condition and inability to hold-up 81-100 0 0 0 0 the solution. IVU were also done in selected cases. Table-II shows the incidence in different age groups. Pre-operative biopsy and histopathology were done The highest incidence was found in the age group of to confirm the clinical findings. Some sorts of 51-60 years age and it was 14(28%) and next was in operations were under taken ranging from biopsy to 31-40 years of age and was 12(24%). One case was radical excision. Pre-operative findings were detected as early as 14 years and 9(18%) cases recorded and total abdominal exploration was made. within 21-30 years. Incidence among people within Tissues were taken from the lesions and the lymph 60-100 years was relatively less, only 02(4%) cases nodes were taken where feasible. and they were carcinoma of right colon. JAFMC Bangladesh. Vol 11, No 2 (December) 2015 37 Table-III: Distribution of faecal occult blood test Table-VII: Operation due to lesions at different sites (n=50) Site Positive Negative Operations Rt colon Lt colon Rectum Total Right colon 15 7 Curative resection 12 (24)% 4 (8%) 16 (32%) 32 (64%) Palliative resection 8 (16%) 2 (4%) 4 (8%) 14 (28%) Left colon 5 1 Table-III shows the result of faecal occult blood test Palliative bypass 2 (4%) 0 (0%) 0 (0%) 2 (4%) of Ca-colon. Fifteen (66%) cases were found De-functioning colostomy 0 0 2 (4) 2 (4%) positive for right colonic carcinoma and 5(82%) Only biopsy 0 0 0 0 patients were for left colon. But 7 (34%) cases and 1 Table-VII shows in22 64%(44%) patients6 (12%) curative22 (44% )resection50 (100% ) (17%) case showed negative result in right and left could be done, of them 16(32%) were rectal colonic carcinoma respectively. carcinoma, 12(24%) of right colon, 4(8%) carcinoma in left colon cancer. The patient with rectal cancer Table-IV: Result of Flexible Colonoscopy either underwent abdomino-perineal resection Site Positive Negative Not Done (APR) or the anterior resection (AR) as curative resection. Palliative resection had been done in 14 cases; palliative bypass was done in 02 cases of Right colon 17 4 1 rectal carcinoma. De-functioning colostomy was Left colon 6 0 0 done in 02 cases of rectal carcinoma. Table-IV shows the colonoscopic report on carcinoma colon. In case of right colon 17 (82%) cases found Table-VIII: Operative morbidity and mortality for positive result and 4 (18%) cases are negative colorectal carcinoma result.
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